Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Lipid Peroxidation, Nitrate And Nitrite Levels In Eclamptic And Intrauterine Growth Retarded Pregnancies, Hati̇ce Paşaoğlu, Nesli̇han Bukan, Gülsen Bulduk, Şevki̇ Çelen
Lipid Peroxidation, Nitrate And Nitrite Levels In Eclamptic And Intrauterine Growth Retarded Pregnancies, Hati̇ce Paşaoğlu, Nesli̇han Bukan, Gülsen Bulduk, Şevki̇ Çelen
Turkish Journal of Medical Sciences
In this study we investigated nitric oxide metabolites nitrate+nitrite and lipid peroxidation product (malonyldialdehyde: MDA) related to the pathogenesis of eclampsia and intrauterine growth retarded (IUGR) pregnancy. Plasma nitrate+nitrite levels were higher in the eclamptic (31.6 ± 16.7 µmol/L p < 0.001) and IUGR (24.3 ± 9.5 µmol/L p < 0.005) groups than in the control group (18.8 ± 6.9 µmol /L). Plasma MDA levels were higher in the eclamptic group (5.5 ± 2.5 nmol/ml (p < 0.05) but not significantly different in the IUGR (3.4 ± 2.4 nmol/ml p > 0.05) group than control group (3.0 ± 1.3 nmol/ml). In addition, the plasma nitrite+nitrate and MDA levels in the eclamptic group were higher than in the IUGR group (p < 0.05). These variations could play different roles in the pathogenesis of eclampsia and IUGR pregnancy.
Histological Changes In The Rat Thoracic Aorta After Chronic Nitric Oxide Synthase Inhibition, Ni̇gar Vardi, Feral Öztürk, Ersi̇n Fadillioğlu, Ali̇ Otlu, Murat Yağmurca
Histological Changes In The Rat Thoracic Aorta After Chronic Nitric Oxide Synthase Inhibition, Ni̇gar Vardi, Feral Öztürk, Ersi̇n Fadillioğlu, Ali̇ Otlu, Murat Yağmurca
Turkish Journal of Medical Sciences
The objective of this study was to determine the morphological effects of chronic nitric oxide (NO) inhibition on the thoracic aorta of Wistar rats. Fifteen male Wistar Albino rats were divided into three groups. Group I rats (control group, n = 5) received tap water, group II rats (n = 5) recieved 100 mg/kg L-NAME (moderate NO inhibiton) and group III rats (n = 5) received 500 mg/kg L-NAME, in drinking water (severe NO inhibition) for 15 days. At the end of 15 days, the carotid arteries of the rats were cannulated and their blood pressure was measured. The rats …