Medicine and Health Sciences Commons^™

Importance Of Fossil And Archaeological Occurrence Data For Understanding The Evolution And Distribution Of The Freshwater Drum (A. Grunniens)., Stephen J. Jacquemin, Lauren J. Fuelling, G. Stringer, A. Smith, Charles N. Ciampaglio

Biological Sciences Faculty Publications

No abstract provided.

Importance And Challenges Of Monitoring Harmful Algal Blooms In Grand Lake St Marys, Stephen J. Jacquemin, M. Morden, C. Ewing, J. C. Doll

Biological Sciences Faculty Publications

No abstract provided.

Beyond The Adhd Diagnosis: Does The Insurance Rate, Mental Health Status In Parents, And Food Availability In The United States Impact Or Predict The Prevalence Of Diagnosis Of Adhd In Children?, Kaitie Kudlac

Scholarship in Medicine - All Papers

More than 6 million children in the US have been diagnosed with ADHD in 2016 and many studies such as those performed through the National Survey of Children’s Health have seen those numbers climbing through 2017.¹ Prevalence of ADHD itself has increased by 42% over the past 8 years.² This study analyzed, through the use of public data available through County Health Ranking and data through the Data Resource Center for Child and Adolescent Health if the insurance status, mental health standing of parents, and food availability in the United States could impact or predict the diagnostic prevalence …

Palliative Performance Scale As A Prognostic Tool For Patients With Dementia In Hospice, Alexandria Nasr

Scholarship in Medicine - All Papers

Objective: Palliative and hospice care have been shown to benefit people with dementia and their families. However, for patients with dementia who are nearing the end of life, hospice referral can be challenging because of the difficulty in predicting prognosis. The objective of this retrospective, exploratory study is two-fold: (1) to describe trajectories by analyzing trends in Palliative Performance Scale (PPS) scores for patients admitted to hospice with a neurocognitive disorder from time of enrollment to time of disenrollment and (2) to determine the relationship between PPS and length of stay (LOS) in hospice care.

Methods: The setting for the …

Access To Care, Food Quality Index, And Employment As Predictors Of Poor Mental Health Days In Ohio, Louisiana, California, And New York, Eugene Matthew P. Almazan

Scholarship in Medicine - All Papers

Objective: Analyze how the availability of mental health providers has changed in Ohio from 2016 to 2020 with relation to changes in mental health outcomes reported. Compare to other regions of the United States (Louisiana, California, New York) in terms of access to healthcare, unemployment status, and food quality index. Lastly, to identify which socioeconomic and health factors are most predictive of poor mental health days.

Methods: Participant data from Ohio (OH), Louisiana (LA), California (CA), and New York (NY) was acquired from countyhealthrankings.org annual survey results that were published from 2016 through 2020. SPSS was utilized for statistical analysis …

Diabetes Link To Social Determinants Of Health, Tyler Schimmoeller

Scholarship in Medicine - All Papers

Objective: The purpose of this paper is to investigate diabetes and how premature death rate; income inequality and social associations relate to diabetes prevalence in the state of Washington in 2020. Methods: I investigated the rate of diabetes change in Washington from 201 to 2020 using a paired t-test. The correlation of diabetes rates and the premature age-adjusted mortality was calculated by county in Washington in 2020 using a Pearson/Spearman correlation. I compared the rate of diabetes in Washington to South Carolina, Ohio, and Louisiana by county in 2020 using an ANOVA with posthoc. Lastly, I used a stepwise linear …

Exploring Preventable Hospital Stays In Maryland, Janet Lubov

Scholarship in Medicine - All Papers

Objective: The objective of this study is to analyze data to determine the factors that influence preventable hospital stays in all Maryland counties. Explicitly, I am examining how preventable hospital stays changes over the past eight years, comparing preventable hospital stays in Maryland and Virginia, correlating preventable hospital stays with Flu vaccinations, and lastly, examining how the rate of uninsured and income inequality can predict the variance in preventable hospital stays by county.

Methods: The data I will be using is sourced from the 2020 County Health Rankings and Roadmaps report. The most recent data available in this published 2020 …

A Multi-Dimensional View On Mental Distress Of Alaskan Adults, Katelyn Hagstrom

Scholarship in Medicine - All Papers

Mental health impacts every facet of day-to-day life, and therefore it is important to determine what factors influence mental wellbeing in order to best target those areas to improve individuals’ mood and health. This paper analyzes how mental distress rates in Alaskan counties are affected by environmental and societal issues such as latitude, insufficient sleep, access to healthy food, presence of severe housing issues and rates of physical inactivity. By specifically studying mental distress in Alaskan residents, the extremes of day length and population size bring a new dimension to previous research done on mental distress. The variables were derived …

Sociodemographic Differences In Breastfeeding Rates For Children Born Between 2010-2015, Megha Patel

Scholarship in Medicine - All Papers

Breastfeeding is a natural component of life and has proven to provide benefits to both the mother and the child. The mother’s mental health as well as physical health including losing pregnancy weight are influenced by breastfeeding. The child receives immune system strengthening leaving them less susceptible to certain diseases in the short term and later in life. There are a variety of factors that have the potential to influence breastfeeding rates. In this study, seven of these factors were examined including sex of the baby, race of the baby, maternal education, poverty income ratio, marital status of the mother, …

The Safe Environment For Every Kid Model: Analyzing Demographics Related To Higher Risks Of Child Maltreatment In High-Risk Pediatric Population, Hannah Redding

Scholarship in Medicine - All Papers

Background: The Safe Environment for Every Kid (SEEK) screener was developed by Dr. Howard Dubowitz for primary care clinicians to identify and address risk factors for child maltreatment. The instrument queries parents/guardians regarding their families' needs (e.g. food insecurity) and screens for depressive symptoms in the parent/guardian.

Objective: To examine the frequency of social determinants of health (e.g., food insecurity) and its correlates using the SEEK screener during pediatric visits at a Federally Qualified Health Center in south central Ohio.

Design/Methods: The SEEK screener was distributed to parents/guardians (PG) at Rocking Horse Community Health Center, a Federally Qualified Health Center …

Prevalence And Perceptions Of Herbal Medicine Use In Eastern Jamaica, Jacqueline Jepsen

Scholarship in Medicine - All Papers

Objective: The purpose of this research was to determine the prevalence of herbal medicine use in rural St. Mary Parish, Jamaica. It also aimed to identify which herbs are commonly used and gauge the population’s general attitude toward herbal remedies vs conventional medicine. Methods: A cross-sectional population survey was developed and distributed at eight different clinics throughout St. Mary Parish, Jamaica with a sample size of 68.

Results: It was determined that herbal medicine use is common amongst the Eastern Jamaican population, with 63% of subjects reporting its use. A wide variety of herbal remedies are utilized, with aloe vera, …

Outcomes And Complications Of Scfe Surgery, Tyler Sanda

Scholarship in Medicine - All Papers

Objective: Slipped capital femoral epiphysis (SCFE) is a common hip disorder affecting children and adolescents. There is much debate concerning best treatment with regards to adverse outcomes, specifically avascular necrosis (AVN). This study analyzed the rates of adverse outcomes after the surgical treatment of SCFEs. It examined risk factors which may lead to the development adverse outcomes. This research will aid clinical decision-making, helping determine optimal surgical treatment of SCFEs and adding to external datasets of SCFE treatment.

Methods: This was a retrospective review of patient health records at a level 2 pediatric trauma hospital. The study included all SCFE …

Determining The Appropriate Technique For Appendix Stump Closure, Cynthia White

Scholarship in Medicine - All Papers

Background In a laparoscopic appendectomy, closure of the appendeceal stump can be done using an endostapler or endoloop. We compared outcome data of the two techniques in patients who underwent laparoscopic appendectomy.

Method We included all patient > 18 years who underwent laparoscopic appendectomy for acute appendicitis at a single institution over a 4-year period. Demographic and outcome data were compared between both groups. Results 501 patients, with no significant differences in age, gender or BMI, were identified for the study. No differences were noted in procedure length, readmission rates, complication rates (including intra-abdominal abscess) or hospital charges. There was a …

Ct Scan Effective Radiation Dose Reduction In Pediatric Trauma Patients, Benjamin Clouse, Elizabeth Ey, Sara J. Paton, Frank Pianki, Jeffrey C. Pence, Lisa Schwing, Melody Campbell

Scholarship in Medicine - All Papers

This project attempts to address the problem of excessive radiation exposure via CT imaging for pediatric patients presenting at adult regional trauma centers.

To answer this question, we utilized the pediatric trauma registry to conduct a retrospective chart review of consisting of all patients under 14 years of age that received trauma related CT imaging and that were transferred from an adult trauma center to Dayton Children’s Hospital in the time period of January 2019 to December 2019.Cases of unnecessary imaging will be determined by subject matter expert review, based on ACS and Image Gently guidelines. Cases of overexposure to …

The Effect Of Endogenous Ligands Of The Aryl Hydrocarbon Receptor On Antibody Expression In A Human B-Cell Model, Valerie Benedict

Browse all Theses and Dissertations

Small changes in antibody expression have broad impacts on human health and disease. An environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces profound immune suppression in animal models in an aryl hydrocarbon receptor (AhR)-mediated fashion. In a human Burkitt's lymphoma cell line (CL-01), TCDD inhibited IgG secretion and differentially impacted Ig heavy chain expression. In addition to TCDD, the AhR has several endogenous, dietary, and bacterial ligands such as 6-formylindolo[3,2-b]carbazole (FICZ) and indole, which are present within the human body at varied concentrations (0.30 mM- 6.64 mM). Both FICZ (100 nM) and indole (100 µM) significantly reduced IgG secretion. Overall antibody secretion is …

Using Fmri Bold Imaging To Motion-Correct Associated, Simultaneously Imaged Pet Data, Joseph M. Williamitis

Browse all Theses and Dissertations

Because magnetic resonance (MR) and positron emission tomography (PET) scanning sessions last long durations, motion blur during scanning constitutes a problem for clinical interpretation. To counteract this, motion-correction algorithms have been developed to reduce smearing between scan slices of MRI, but these algorithms are not commonplace for PET. This feasibility study determined if applying MRI motion-correction algorithms to simultaneously acquired PET data improved PET signal clarity in specific brain regions. Seven subjects received increasing levels of PET tracers while undergoing two separate simultaneous PET/MRI scans. We modified existing fMRI algorithms to apply them to the accompanying PET data. We hypothesized …

Using Functionalized Benzylidene Oxindoles To Determine An Improved Monoamine Oxidase-B Inhibitor As A Therapeutic Agent For Parkinson's Disease, Christine Morgan Kinstedt

Browse all Theses and Dissertations

With the intent to create an optimized monoamine oxidase-B (MAO-B) inhibitor, researchers in this investigation synthesized derivatives of the benzylidene oxindole scaffold in order to determine a lead molecule for further drug development. Previous work in this laboratory group evaluated a similar scaffold, the chalcone structural unit. As this class of compounds was determined to possess the ability to permeate the blood brain barrier (BBB) and to act as potent MAO-B inhibitors, it was posited that scaffold hopping from this previously studied molecular skeleton to benzylidene oxindoles would provide analogous results. Benzylidene oxindoles are readily synthesized via the Claisen-Schmidt condensation …

Tumor Necrosis Factor Alpha Snp Variant In Promoter Region G308a, Cause Preeclampsia During Pregnancy In Pakistani Women, A Case Control Study, Azizah Ziauddin, Sadia Ahmad, Asad Iqbal, Abdul Majid Khan, Shahid Mahmood Baig

Journal of Bioresource Management

Preeclampsia (PE) is a very common critical condition during pregnancy. As PE is a high-risk condition during pregnancy, occurring in 25% of all pregnancies, worldwide. In women with PE there is an increase in hypertension and albuminuria. Elevated blood pressure can be life-threatening after 20^th week of pregnancy. Single nucleotide variation in gene sequence can be disease causing, among these pathogenic SNPs, a variant in TNF-α, G308A is analyzed in many studies as a causative variant to cause preeclampsia. In this case control study fifty patients and fifty healthy individuals were enrolled for analysis of TNF-α promoter region …

Exercise Improves Endothelial Function Associated With Alleviated Inflammation And Oxidative Stress Of Perivascular Adipose Tissue In Type 2 Diabetic Mice, Jinju Wang, Venkata Polaki, Shuzhen Chen, Ji Chen Bihl, Pasquale Pagliaro

Pharmacology and Toxicology Faculty Publications

Perivascular adipose tissue (PVAT), a type of adipose tissue that surrounds the blood vessels, has been considered an active component of the blood vessel walls and involved in vascular homeostasis. Recent evidence shows that increased inflammation and oxidative stress in PVAT contribute to endothelial dysfunction in type 2 diabetes (T2D). Exercise is an important nonpharmacological approach for vascular diseases. However, there is limited information regarding whether the beneficial effects of exercise on vascular function is related to the PVAT status. In this study, we investigated whether exercise can decrease oxidative stress and inflammation of PVAT and promote the improvement of …

Exosomes From Mirna-126-Modified Endothelial Progenitor Cells Alleviate Brain Injury And Promote Functional Recovery After Stroke, Jinju Wang, Shuzhen Chen, Wenfeng Zhang, Yanfang Chen, Ji Chen Bihl

Pharmacology and Toxicology Faculty Publications

Aims: We previously showed that the protective effects of endothelial progenitor cells (EPCs)-released exosomes (EPC-EXs) on endothelium in diabetes. However, whether EPC-EXs are protective in diabetic ischemic stroke is unknown. Here, we investigated the effects of EPC-EXs on diabetic stroke mice and tested whether miR-126 enriched EPC-EXs (EPC-EXs miR126 ) have enhanced efficacy. Methods: The db/db mice subjected to ischemic stroke were intravenously administrated with EPC-EXs 2 hours after ischemic stroke. The infarct volume, cerebral microvascular density (MVD), cerebral blood flow (CBF), neurological function, angiogenesis and neurogenesis, and levels of cleaved caspase-3, miR-126, and VEGFR2 were measured on day 2 …

Risk Factors Associated With Infection In Open Fractures Of The Upper And Lower Extremities, Paul Tornetta, Gregory J. Della Rocca, Saam Morshed, Clifford Jones, Diane Heels-Ansdell, Sheila Sprague, Brad Petrisor, Kyle J. Jeray, Gina Del Fabbro, Sofia Bzovsky, Mohit Bhandari, Gordon H. Guyatt, Stephen D. Walter, Emil H. Schemitsch, Jeffrey Anglen, Michael Bosse, Susan Liew, Parag Sancheti, Paula Mckay, Kim Madden, Kerry Tai, Lisa Buckingham, Aravin Duraikannan, Stephanie L. Tanner, Rebecca G. Snider, Douglas Altman, Rajiv Gandhi, Markus Bischoff, Bill Ristevski, Krishan Rajaratnam, Dale Williams, Flow Investigators

Orthopaedic Surgery Faculty Publications

Introduction: Open fractures are associated with a high risk of infection. The prevention of infection is the single most important goal, influencing perioperative care of patients with open fractures. Using data from 2,500 participants with open fracture wounds enrolled in the Fluid Lavage of Open Wounds trial, we conducted a multivariable analysis to determine the factors that are associated with infections 12 months postfracture. Methods: Eighteen predictor variables were identified for infection a priori from baseline data, fracture characteristics, and surgical data from the Fluid Lavage of Open Wounds trial. Twelve predictor variables were identified for deep infection, which included …

Psychological Stress, Its Reduction, And Long-Term Consequences: What Studies With Laboratory Animals Might Teach Us About Life In The Dog Shelter, Michael B. Hennessy, Regina M. Willen, Patricia A. Schiml

Psychology Faculty Publications

There is a long history of laboratory studies of the physiological and behavioral effects of stress, its reduction, and the later psychological and behavioral consequences of unmitigated stress responses. Many of the stressors employed in these studies approximate the experience of dogs confined in an animal shelter. We review how the laboratory literature has guided our own work in describing the reactions of dogs to shelter housing and in helping formulate means of reducing their stress responses. Consistent with the social buffering literature in other species, human interaction has emerged as a key ingredient in moderating glucocorticoid stress responses of …

12 Tips For Implementing Peer Instruction In Medical Education, Dean Parmelee, Mary Jo Trout, Irina Overman, Michael P. Matott

Medical Education Faculty Publications

Peer Instruction (PI) is a vibrant instructional strategy, used successfully for over two decades in undergraduate physics and mathematics courses. It has had limited use and few publications in medical education. This 12 TIPS provides a focused review on the evidence supporting its use in higher education and rationale for its wider adoption in medical education. The authors detail important steps for its implementation with large classes. Based on several years of experience with PI in a US allopathic medical school, they feel that PI attends to core principles from the science of learning and provides students and faculty with …

Outcomes And Management Approaches Of Resuscitative Endovascular Balloon Occlusion Of The Aorta Based On The Income Of Countries, Ramiro Manzano-Nunez, David Mcgreevy, Claudia P. Orlas, Alberto F. Garciá, Tal M. Hörer, Joseph Dubose, Carlos A. Ordoñez, Aast-Aorta Investigators And The Abotrauma Registry Group

Department of Surgery Faculty Publications

Background: Resuscitative endovascular balloon occlusion of the aorta (REBOA) could provide a survival benefit to severely injured patients as it may improve their initial ability to survive the hemorrhagic shock. Although the evidence supporting the use of REBOA is not conclusive, its use has expanded worldwide. We aim to compare the management approaches and clinical outcomes of trauma patients treated with REBOA according to the countries' income based on the World Bank Country and Lending Groups. Methods: We used data from the AORTA (USA) and the ABOTrauma (multinational) registries. Patients were stratified into two groups: (1) high-income countries (HICs) and …

Accidental Silver Clay Tattoo: Mystery Finding In A Jewelry Smith, Tom Selby, Christina E. Borchers, Jeffery B. Travers, Samia Borchers

Dermatology Faculty Publications

Permanent tattoos result from the introduction of insoluble pigmentsinto the dermis. The mechanism can be intentional for cosmetic ormedical purposes, as with professional tattooing; or accidental asseen with carbon-related traumatic tattooing. Pigments are generallycomposed of various inorganic salts or metals. Pathology in non-inflamed tattoos will show dermal pigment granules of different sizesand shapes.1 Local inflammatory reactions can occur.Unintentional tattooing related to trauma involving asphalt, carbon,graphite, and gun powder are well known. Other cases involvingjewelry and fireworks have been reported in the literature.2,3 Similarissues arise with accidental placement of amalgam in the oralmucosa during dental procedures.4 We present an interesting caseof …

Microbial Diversity In The Sawmill Environment: Implications On The Health Of Sawmill Workers And Merchants, Nigeria, Ebere J. Okafor-Elenwo Ej, Odaro S. Imade Os, Osazee E. Izevbuwa Eo

Journal of Bioresource Management

There is an increasingly high suspicion of occupational health diseases amongst workers in sawmill factories. Hence this study aimed to determine the microbial diversity in some sawmill factories in Okada, Edo State, Nigeria to evaluate potential implications of the factory’s processing area on the health of the workers and wood merchants. Bacteria and fungi count in the bioaerosols within the processing area of each factory was performed with the passive air sampling technique. While in the sawdust samples, microbial counts were carried out with the pour plate technique. Identification of the microbes was performed with macroscopic and microscopic examinations as …

Prevalence Of Tuberculosis In District Haveli, Azad Jammu And Kashmir, Abu Ul Hassan Faiz, Ghazal Tariq, Ayesha Faiz, Lariab Zahra Faiz

Journal of Bioresource Management

Tuberculosis is an infectious disease with a common occurrence in population of Azad Jammu and Kashmir. The current study was designed to find out the prevalence of TB among the general population of a less developed District Haveli. Samples were collected from different hospitals and TB centers located in district Haveli and tested through sputum smear microscopy for conformation of positive for TB. The three-year (2015 to 2018) study was conducted to record prevalence of tuberculosis in selected area of Azad Jammu and Kashmir. The trend line of prevalence was made by using (SPSS software). Results produced linear trends yearly …

Effects Of Neuronic Shutter Observed In The Eeg Alpha Rhythm, Kevin E. Alexander, Justin R. Estepp, Sherif M. Elbasiouny

Neuroscience, Cell Biology & Physiology Faculty Publications

The posterior alpha (α) rhythm, seen in human electroencephalogram (EEG), is posited to originate from cycling inhibitory/excitatory states of visual relay cells in the thalamus. These cycling states are thought to lead to oscillating visual sensitivity levels termed the “neuronic shutter effect.” If true, perceptual performance should be predictable by observed α phase (of cycling inhibitory/excitatory states) relative to the timeline of afferentiation onto the visual cortex. Here, we tested this hypothesis by presenting contrast changes at near perceptual threshold intensity through closed eyelids to 20 participants (balanced for gender) during times of spontaneous α oscillations. To more accurately and …

Atypical Mycobacterium Marinum: A Case Of Fish Tank Granuloma, Emily Wooton, Christina E. Borchers, Samia Borchers, Nicholas Shamma, Bernard Rose, Max Rubin

Dermatology Faculty Publications

Our case involves a 76-year-old female who presented to her family physician with a presumed infection on her right dorsal hand and wrist, which she believed to be secondary to a possible stick pin or spider bite at a department store while rummaging through jeans.

Human Botfly Infestation: Furuncular Myiasis, Rachel Rhee, Christina E. Borchers, Samia Borchers, Gregory Maupin, Jeffery Weinstein

Dermatology Faculty Publications

Dermatobia hominis is one of many species of botflies whose larvae is parasitic to humans and is uniquely indigenous to Central and South America. The larvae of the human botfly gain nutrients to survive by feeding underneath mammal skin. As a consequence, within 24 hours, small 2- 3mm painful, erythematous, draining, and purulent papules with a classical air-pore develop as the initial cutaneous sign. At first, the lesions resemble that of an insect bite, but over time they enlarge to 10-35mm in diameter with a surrounding area of induration. The most common areas where the larvae are cutaneously deposited include …