Medicine and Health Sciences Commons^™

Cutaneous Invasive Ductal Carcinoma Masquerading As Pseudoxanthoma Elasticum, Christina E. Borchers, Hershel Dobkin, Zachary Ingersoll, Marc Handler

Dermatology Faculty Publications

In the United States, 214,880 women are diagnosed with breast carcinomaeach year, with an overall 5-year survival of 90%. When cutaneousmetastases are present, the 5-year survival is 24%. Invasive ductalcarcinoma (IDC) comprises 80% of all breast cancers, with 30% of womenhaving metastatic disease upon initial diagnosis. Cutaneous metastases ofbreast carcinoma occurs at a rate of 24% per primary breast malignancywith 70% of breast carcinoma cutaneous metastases being IDC subtype.Our patient presented as clinically exhibiting features of pseudoxanthomaelasticum (PXE), a genetic disease affecting connective tissue inintertriginous areas, but upon pathologic examination revealed metastaticIDC. Review of the literature has not elicited other …

Current Scenario Of Covid-19 With Epidemiological And Phylogenetic Analysis Of Pakistani Coronavirus: A Review, Asma Altaf, Wafa Iqbal, Sidra Younis, Farah Deeba

Journal of Bioresource Management

A novel corona virus named as 2019 n-CoV was identified to be the actual cause of an outbreak of respiratory illness in Wuhan, China beginning in late December 2019. This respiratory disease was named as COVID-19 by WHO. There are many countries affected by COVID-19 including Pakistan. In this review we have provided a brief introduction of COVID-19 and discussed epidemiological and phylogenetic analysis of Pakistani novel corona virus strain. Our epidemiological analysis of data till 16^th May 2020 showed rapidly increasing number of new cases, while at the same time a higher recovery rate than number of deaths …

Inter- And Intra-Physician Variation In Quantifying Actinic Keratosis Skin Photodamage, Benjamin Schmeusser, Christina E. Borchers, Jeffrey B. Travers, Samia Borchers, Justin Trevino, Max Rubin, Heidi Donnelly, Karl Kellawan, Lydia Carpenter, Shalini Bahl, Craig A. Rohan, Elizabeth Muennich, Scott Guenthner, Holly Hahn, Ali Rkein, Marc Darst, Nico Mousdicas, Elizabeth E. Cates, Ulas Sunar, Trevor J. Bihl

Dermatology Faculty Publications

We investigated the variations in physician evaluation of skin photodamage based on a published photodamage scale. Of interest is the utility of a 10-level scale ranging from none and mild photodamage to actinic keratosis (AK). The dorsal forearms of 55 adult subjects with various amounts of photodamage were considered. Each forearm was independently evaluated by 15 board-certified dermatologists according to the Global Assessment Severity Scale ranging from 0 (less severe) to 9 (the most progressed stage of skin damage). Dermatologists rated the levels of photodamage based upon the photographs in blinded fashion. Results show substantial disagreement amongst the dermatologists on …

Wright State University Boonshoft School Of Medicine, Brenda Roman, Colleen Hayden, Irina Overman

Medical Education Faculty Publications

No abstract provided.

Spotlight Commentary: Why We Need To Pay Attention To Toxicity Associated With Herbal Medicines, Elena Y. Enioutina, Kathleen M. Job, Catherine M.T. Sherwin

Pediatrics Faculty Publications

No abstract provided.

C6-Ceramide Treatment Inhibits The Proangiogenic Activity Of Multiple Myeloma Exosomes Via The Mir-29b/Akt Pathway, Liping Liu, Qinmao Ye, Langni Liu, Ji Chen Bihl, Yanfang Chen, Jing Liu, Qian Cheng

Pharmacology and Toxicology Faculty Publications

Background The increased bone marrow angiogenesis is involved in the progression of multiple myeloma (MM) with the underlying mechanism poorly understood. Cancer-released exosomes could play an important role in the pathological angiogenesis through exosomal microRNAs (miRs) delivery. It is reported that miR-29b played an important role in regulating the tumor angiogenesis. Methods In this study, we explored the role of C6-ceramide (C6-cer, a Ceramide pathway activator) in the angiogenic effect of MM exosomes and its potential mechanism. MM cells (OPM2 and RPMI-8226) treated with C6-cer were studied for its effects on the endothelial cell (EC) functions. Results Our results showed …

Renal Survival In Children With Glomerulonephritis With Crescents: A Pediatric Nephrology Research Consortium Cohort Study, Joseph G. Maliakkal, M. John Hicks, Mini Michael, David T. Selewski, Katherine Twombley, Michelle N. Rheault, Meredith Seamon, Jason M. Misurac, Cheryl L. Tran, Loretta Reyes, Joseph T. Flynn, Ali M. Onder, Alexandru R. Constantinescu, Vaishali Singh, Cynthia Pan, Abiodun Aderogba Omoloja, Qiang Wu, William E. Smoyer, Guillermo Hidalgo, Scott E. Wenderfer

Pediatrics Faculty Publications

There is no evidence-based definition for diagnosing crescentic glomerulonephritis. The prognostic implications of crescentic lesions on kidney biopsy have not been quantified. Our objective was to determine risk factors for end-stage kidney disease (ESKD) in patients with glomerulonephritis and crescents on kidney biopsy. A query of the Pediatric Nephrology Research Consortium’s Pediatric Glomerulonephritis with Crescents registry identified 305 patients from 15 centers. A retrospective cohort study was performed with ESKD as the primary outcome. Median age at biopsy was 11 years (range 1–21). The percentage of crescents was 3–100% (median 20%). Etiologies included IgA nephropathy (23%), lupus (21%), IgA vasculitis …

Gynecologic Surgrete, New Horizons Guyana 2019: An Experience Of A Lifetime For Global Health Engagement And Medical Readiness, Bethany L. Charron, Katherine L. Dengler, Bao Tram Nguyen, Ashley Coggins, Jason C. Massengill, Trisha J. Tomkins

Obstetrics and Gynecology Faculty Publications

New Horizons is an annual training exercise designated for military medical professionals and civil engineers to assist partner nations of Southern Command (SOUTHCOM), as well as provide exceptional training to U.S. military members.1 In Spring of 2019, a gynecologic surgery readiness training exercise (SURGRETE) team composed of 16 joint-service military healthcare professionals, specifically including a fellowship-trained female pelvic medicine and reconstructive surgery (FPMRS) surgeon, an FPMRS fellow, an obstetrics and gynecology (OB/GYN) specialist, three OB/GYN residents, and additional anesthesia, nursing, and surgical technician support, traveled to Guyana to participate in the New Horizons global health exercise. The mission of the …

Trends In Cancer Prevalence In Punjab, Pakistan: A Systematic Study From 2010 To 2016, Sana Hafeez, Asmat Mahmood, Rizwan Ullah Khan, Naila Malkani

Journal of Bioresource Management

Cancer is the second leading cause of death globally. However, in Pakistan, in the absence of a national cancer registry, it is difficult to predict the current status of cancer incidence. Therefore, a need was felt to design a study that can give a depiction of the prevalence of common cancer types and their relevance to the local population in the absence of a proper cancer registry system. In view of this, data was collected from 2010 to 2016 for breast, prostate, head and neck, cervical and colorectal cancer from the cancer hospitals and centres located all over Punjab, Pakistan. …

Mir-132-3p Priming Enhances The Effects Of Mesenchymal Stromal Cell-Derived Exosomes On Ameliorating Brain Ischemic Injury, Qunwen Pan, Xiaoli Kuang, Shuyun Cai, Xiang Wang, Donghui Du, Jinju Wang, Yan Wang, Yanyu Chen, Ji Chen Bihl, Yanfang Chen, Bin Zhao, Xiaotang Ma

Pharmacology and Toxicology Faculty Publications

Backgrounds/aims: Mesenchymal stromal cell-derived exosomes (MSC-EXs) could exert protective effects on recipient cells by transferring the contained microRNAs (miRs), and miR-132-3p is one of angiogenic miRs. However, whether the combination of MSC-EXs and miR-132-3p has better effects in ischemic cerebrovascular disease remains unknown. Methods: Mouse MSCs transfected with scrambler control or miR-132-3p mimics were used to generate MSC-EXs and miR-132-3p-overexpressed MSC-EXs (MSC-EXsmiR-132-3p). The effects of EXs on hypoxia/reoxygenation (H/R)-injured ECs in ROS generation, apoptosis, and barrier function were analyzed. The levels of RASA1, Ras, phosphorylations of PI3K, Akt and endothelial nitric oxide synthesis (eNOS), and tight junction proteins (Claudin-5 and …

The Perils Of Recreational Marijuana Use: Relationships With Mental Health Among Emergency Department Patients, Catherine A. Marco, John Paul Detherage Iii, Ashley Lafountain, Megan Hanna, Justin Anderson, Rachel Rhee, Jacqueline Ziegman, Dennis Mann

Emergency Medicine Faculty Publications

Abstract Introduction Marijuana is a commonly used drug in the United States. Many states have legalized the recreational use of marijuana. The effects of marijuana on mental health are unknown. Methods In this prospective survey study, eligible participants included ED patients age 18 and older, who had ever used recreational marijuana. A survey instrument was developed, piloted, and revised. Data collected included reasons for marijuana use, marijuana's perceived effectiveness, and history of mental health conditions, including depression, anxiety, and suicidal thoughts. Results Among 303 participants (86% response rate), the median age of first marijuana use was 16 ([IQR 14, 19], …

Seroprevalence, Biochemical Investigation And Risk Factor Assessment For Hbv & Hcv Infection In Hospital Based Patients Of Islamabad, Pakistan, Narmeen Adnan Rana, Bushra Munir, Nazeer Hussain, Nazia Imtiaz, Muhammad Asif Gondal Dr., Fahed Parvaiz Dr.

Journal of Bioresource Management

Viral hepatitis poses a serious threat to mankind. Hepatitis B and C Virus are blood borne pathogens that affect millions of individually globally. This study was conducted on a hospital-based population in Islamabad, Pakistan over a period of 4 months, utilizing ELISA as the diagnostic technique which suggested a higher seroprevalence rate for both HBV and HCV i.e. 2.07% and 8.24% respectively. A correlational analysis of the biochemical parameters of these individuals with HBV and HCV infection was carried out and the results indicated a positive correlation of HBV with Alkaline Phosphatase (ALP), HCV with Total Bilirubin (TBil) and both …

Crisis Standards Of Care And Covid-19, Sharon L. Farra, Sherrill Jeanne Smith, Laura M. Luehrmann, Craig Woolley

Nursing Faculty Publications

This is the sixth installment in the Shelter in Place (SiP) Lecture series. This installment deals with the impact and implications of the Shelter in Place order on differing populations. It discusses the details of Crisis Standards of Care from development to implementation.

Addressing Covid 19 Among Vulnerable Populations, Tim Crawford, Sydney Silverstein, Craig Woolley, Laura M. Luehrmann

Population and Public Health Sciences Faculty Publications

This is the fifth installment in the Shelter in Place (SiP) Lecture series. This installment deals with the impact and implications of the Shelter in Place order on differing populations. It discusses how a variety of populations have differing experiences with social distancing, the virus, and other implications of the current pandemic.

Depressed Neuromuscular Transmission Causes Weakness In Mice Lacking Bk Potassium Channels, Xueyong Wang, Steven R.A. Burke, Robert J. Talmadge, Andrew A. Voss, Mark M. Rich

Neuroscience, Cell Biology & Physiology Faculty Publications

Mice lacking functional large-conductance voltage- and Ca2+-activated K+ channels (BK channels) are viable but have motor deficits including ataxia and weakness. The cause of weakness is unknown. In this study, we discovered, in vivo, that skeletal muscle in mice lacking BK channels (BK−/−) was weak in response to nerve stimulation but not to direct muscle stimulation, suggesting a failure of neuromuscular transmission. Voltage-clamp studies of the BK−/− neuromuscular junction (NMJ) revealed a reduction in evoked endplate current amplitude and the frequency of spontaneous vesicle release compared with WT littermates. Responses to 50-Hz stimulation indicated a reduced probability of vesicle release …

Proceedings - Wright State University Boonshoft School Of Medicine Twelfth Annual Medical Student Research Symposium, Office Of Research Affairs, Boonshoft School Of Medicine

Medical Student Research Symposium Proceedings

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's Twelfth Annual Boonshoft School of Medicine Medical Student Research Symposium held on April 21, 2020.

Comment: Probably A Good News: Covid-19 Is Not Spreading Fast In Tropical Region Like In Temperate Region, Madeeha Manzoor

Journal of Bioresource Management

My understanding of Covid-19 is that, there are some climatic factors involved in seed spread of this virus. As it started from the area of China which falls under temperate zone, its second victim was Iran’s city Qom which also falls under temperate zone and third is Italy which is completely in temperate zone.

Data from two countries from Temperate zone and three countries from Tropical zone was compared. The days counted from the 100 cases each country reached as day one and further days studied on equal basis.

Covid 19 What You Need To Know, Dawn P. Wooley, Giancarlo Mariani, Craig Woolley, Laura M. Luehrmann

Neuroscience, Cell Biology & Physiology Faculty Publications

This is the first presentation in the new Shelter-in-Place lecture series. This first lecture is two-fold. First, it covers the basics of the COVID-19 virus including: how it spreads, possible origin, and other pertinent information. This portion of the presentation was followed by an overview of the international recruitment efforts in response to the virus, including: student perspectives, recruitment methods, and other important information.

In Those Who Smoke, How Does Vaping Compared With Cigarette Smoking, Influence Respiratory Complications Over 6 Months?, Allyson E. Jackson, Lindsey N. Jettinghoff, Micah J. Carter

Lake Campus Research Symposium Abstracts and Posters

The respiratory system is a vital system in the body. There are a lot of ways to harm the respiratory system and create irreversible complications. Smoking cigarettes has been around for many years and most people are aware of some of the respiratory complications that it can cause. Those who are adult smokers are at risk for developing asthma, COPD, TB, and much more. A new form of smoking is vaping, and many are unaware of the impact it can have on the respiratory system. The research completed on vaping is showing damage to the lining and alveoli in the …

Relief Of Procedural Pain In Infants And Neonates, Allye Camden

The University Honors Program

Procedural pain occurs in the hospital setting due to a variety of procedures and treatments conducted throughout a patient’s stay. Pain is often assessed in infants and neonates but is not always treated consistently due to the multiple number of pain relief methods. The objective of this literature review is to identify the most effective interventions to relieve procedural pain in infants and neonates. Forty articles were analyzed and synthesized to determine the best pain relief methods to use when providing nursing care to infants and neonates. Based on the results of the literature review, nutritive sucking, positioning techniques, and …

Alcohol Consumption And Its Effect On Liver Transplant Failure, E. Short, R. Pinchot

Lake Campus Research Symposium Abstracts and Posters

There is a stringent process to determine who can receive liver transplants. Alcohol is an important part of this process, with US transplant centers requiring a period of abstinence prior to transplant, lack of access to livers for alcoholics due to beliefs about their ability to stay sober, and monitoring of people considered "high risk" for recidivism after the transplant. While there is clear data on post-transplant alcohol use in transplant recipients with alcoholic hepatitis, more recent data has shown comparable alcohol use rates in non-alcoholic hepatitis patients, which makes the impact of alcohol use on transplant failure rates regardless …

Pcos And Obesity’S Effects On Pregnancy, Mya Hager, Kylee Kiel, Jordan Sailor

Lake Campus Research Symposium Abstracts and Posters

PCOS is one of the most prominent female reproductive disorders and with that comes fears for women about their health and ability to safely bear children. Women diagnosed with a reproductive disorder commonly fear they won’t be able to reproduce. This is not the case for the majority of obese women, PCOS does increase the risk of developing gestational diabetes, hypertension, and preterm labor. All of these complications can negatively affect the outcome of her pregnancy, therefore the mom needs to be closely monitored and healthcare workers intervene when appropriate. Pregnancy for an obese woman with PCOS can be challenging …

The Effects Of Kangaroo Care On Parental-Infant Bonding, Megan Stroud, Cortney Voisard, Quinn High

Lake Campus Research Symposium Abstracts and Posters

Welcoming home a new baby is a challenging and sometimes stressful situation for even the most seasoned of parents. There are several decisions parents must make about the care their new baby will receive. One of those choices is kangaroo care. Although this intervention may not always be performed due to immediate medical concerns, immediate bathing, hospital policies, and cultural norms, it has been proven to have several benefits. Kangaroo care is defined as skin to skin contact in which the baby is placed on a parent’s bare chest and is swaddled in warm blankets similar to how a mother …

Breast Feeding Vs Bottle Feeding Effecting The Amount Of Hospitalizations In The First Year, Haley Maurer, Becca Young, Shelby Bohman

Lake Campus Research Symposium Abstracts and Posters

Breastfeeding and formula feeding are two ways to feed an infant after it is born. The importance of this is significant because of infections that children are suspectable to at such a young age. Children who breastfeed exclusively are shown to have lower infection/hospitalization rates than children who are formula-fed. Breastmilk has several qualities that help prevent infections in infants that formula does not. Formula is a good source of nutrients but it does not have the ability to stop infections from occurring. Infections can be very serious for infants especially if they are born preterm so having a way …

In Utero Drug Exposure Impact On Infant Health, Katie Edwards, Lisa M. Borges, Carlie J. Schoenherr

Lake Campus Research Symposium Abstracts and Posters

Drug use during pregnancy has many impacts on the baby’s and mother’s health. Prenatal drug use affects a child’s development during his or her life. When exposed to in utero drug use the baby tends to have a lower birth weight, preterm birth, and intrauterine growth restrictions compared to a baby not exposed to drugs. The number of infants being born with withdrawal to drugs is increasing. This is an important problem because the number of fetuses exposed in utero to drugs is increasing. Research shows that exposure does pose a risk to the fetus and birth outcomes. Finding and …

Predictors Of New-Onset Atrial Fibrillation In Geriatric Trauma Patients, Catherine A. Marco, Jennifer Lynde, Blake Nelson, Joshua Madden, Adam Schaefer, Claire Hardman, Mary Mccarthy

Emergency Medicine Faculty Publications

Geriatric patients (age >65) comprise a growing segment of the trauma population. New-onset atrial fibrillation may occur after injury, complicating clinical management and resulting in significant morbidity and mortality. This study was undertaken to identify clinical and demographic factors associated with new-onset atrial fibrillation among geriatric trauma patients . Methods: In this case control study, eligible participants included admitted trauma patients age 65 and older who developed new-onset atrial fibrillation during the hospitalization. Controls were admitted trauma patients who were matched for age and injury severity score, who did not develop atrial fibrillation. We evaluated the associations between new-onset atrial …

The Effects Of Music On Anxious Autistic Patients, C. Homan, Emily M. Buening

Lake Campus Research Symposium Abstracts and Posters

High levels of stress and low self-esteem are common in autistic individuals, especially with young adults. Various techniques have been done to help these levels even including musical interventions. Not many people know the effects music therapy has on a patient with autism. However, music can decrease the effects of anxiety and heighten self-esteem. Music therapy gives autistic patients the ability to learn how to control outbursts through music. Music therapy can allow a patient with severe autism the ability to share their emotions, and allow them to gain self-worth.

The Wright State – Lake Campus 2019 – 2020 Scholarly Review, Wright State University - Lake Campus

Lake Campus Research Symposium Reports

This report provides a listing of the scholarly endeavors from Lake Campus during the 2019 calendar year, spanning across disciplines.

This document contains the Annual Research Report from 2019 and the Research Symposium Program from 2020.

Vital Signs, Spring 2020, Boonshoft School Of Medicine

Vital Signs

A thirty-one page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

How Do Surgeon Preferences And Technique Variances Affect Outcome?, Anastasia Axiopoulou, Caroline G. L. Cao, Katherine Lin Md, Keith Watson Md

Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials

The goal of the research project is to create a blue-print of a robot-assisted hysterectomy procedure to support design and evaluation of technology to enhance system performance. To create this blue-print, we will conduct a task analysis, model the cognitive task flow and decision making, and develop a simulation of the hysterectomy procedure. The surgical simulation will be used as a platform to train surgeons on robotic-assisted hysterectomies, as well as to assess learning and performance. Additionally, it will be used to design and develop techniques and novel technology to support surgeons in their performance of the surgery. Current research …