Medicine and Health Sciences Commons^™

A Set Of Smart Practices For Public Health Department Accreditation By Public Health Accreditation Board, Veer Raghava Kumar Marthy

Master of Public Health Program Student Publications

Purpose: The purpose of this research is to determine smart practices that could be used by a public health department to have an efficient, productive and successful accreditation by the Public Health Accreditation Board (PHAB).

Methodology: Accreditation coordinators of eight accredited Ohio-based public health departments were interviewed in 2016. A qualitative study was conducted using semi-structured interviews with funneling. Results were generated using a hybrid model of analysis that included a content analysis to make valid inferences from the interview data.

Results: The accreditation coordinators identified a series of smart practices. Six prominent themes that were identified and labeled as …

Best Practices: Emergency Medical Management To Hydrazine Exposure, M. Bradley Brough

Master of Public Health Program Student Publications

Objective: Hydrazine is a toxic industrial chemical with significant health risk. It is commonly used in aerospace technologies as a propellant fuel source for rockets and aircraft. The purpose of this project was to perform a comparative analysis of the emergency algorithms at United States Air Force installations where occupational hydrazine exposure may occur and then create a best practices approach for medical responders.

Methods: After review of current Occupational Safety and Health Administration standards and requirements for hydrazine, six United States Air Force Medical Group installation response protocols were analyzed and compared to each other and to current medical …

Enhanced Control Of Dorsolateral Prefrontal Cortex Neurophysiology With Real-Time Functional Magnetic Resonance Imaging (Rt-Fmri) Neurofeedback Training And Working Memory Practice, Matthew Sherwood, Jessica Kane, Michael Patrick Weisend, Jason G. Parker

Wright State Research Institute Publications

Real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback can be used to train localized, conscious regulation of blood oxygen level-dependent (BOLD) signals. As a therapeutic technique, rt-fMRI neurofeedback reduces the symptoms of a variety of neurologic disorders. To date, few studies have investigated the use of self-regulation training using rt-fMRI neurofeedback to enhance cognitive performance. This work investigates the utility of rt-fMRI neurofeedback as a tool to enhance human cognition by training healthy individuals to consciously control activity in the left dorsolateral prefrontal cortex (DLPFC). A cohort of 18 healthy participants in the experimental group underwent rt-fMRI neurofeedback from the left …

Department Of Surgery Update, January 2016, Wright State University Department Of Surgery

Department of Surgery Updates

A three page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, committee meetings, scholarly activity and more.

Current And Desired Practice Patterns Of Trauma And Acute Care Surgeons (T/Acs), Nathan M. Droz, Melissa L. Whitmill, Priti Parikh, Kimberly M. Hendershot

Department of Surgery Faculty Publications

Resident hour restrictions and the addition of emergency general surgery (EGS) have changed how the T/ACS team functions and their work patterns. The purpose of our study is to report current practice patterns of T/ACS and compare those to desired practice patterns of the future workforce in the field (residents/fellows).

Microvascular Endothelial Cells-Derived Microvesicles Imply In Ischemic Stroke By Modulating Astrocyte And Blood Brain Barrier Function And Cerebral Blood Flow, Qunwen Pan, Caixia He, Hua Liu, Xiaorong Liao, Bingyan Dai, Yanfang Chen, Yi Yang, Bin Zhao, Ji C. Bihl, Xiaotang Ma

Pharmacology and Toxicology Faculty Publications

Background

Endothelial cell (EC) released microvesicles (EMVs) can affect various target cells by transferring carried genetic information. Astrocytes are the main components of the blood brain barrier (BBB) structure in the brain and participate in regulating BBB integrity and blood flow. The interactions between ECs and astrocytes are essential for BBB integrity in homeostasis and pathological conditions. Here, we studied the effects of human brain microvascular ECs released EMVs on astrocyte functions. Additionally, we investigated the effects of EMVs treated astrocytes on regulating BBB function and cerebral ischemic damage.

Results

EMVs prepared from ECs cultured in normal condition (n-EMVs) or …

Endothelial Progenitor Cells And Neural Progenitor Cells Synergistically Protect Cerebral Endothelial Cells From Hypoxia/Reoxygenation-Induced Injury Via Activating The Pi3k/Akt Pathway, Jinju Wang, Yusen Chen, Yi Yang, Xiang Xiao, Shuzhen Chen, Cheng Zhang, Bradley S. Jacobs, Bin Zhao, Ji C. Bihl, Yanfang Chen

Pharmacology and Toxicology Faculty Publications

Background

Protection of cerebral endothelial cells (ECs) from hypoxia/reoxygenation (H/R)-induced injury is an important strategy for treating ischemic stroke. In this study, we investigated whether co-culture with endothelial progenitor cells (EPCs) and neural progenitor cells (NPCs) synergistically protects cerebral ECs against H/R injury and the underlying mechanism.

Results

EPCs and NPCs were respectively generated from inducible pluripotent stem cells. Human brain ECs were used to produce an in vitro H/R-injury model. Data showed: 1) Co-culture with EPCs and NPCs synergistically inhibited H/R-induced reactive oxygen species (ROS) over-production, apoptosis, and improved the angiogenic and barrier functions (tube formation and permeability) in …

The Anatomy Of Nursing Interruptions: Who-What-When-Where, Pratik J. Parikh, Nicole Craker, Robert A. Myers, Jessy M. Eid, Priti Parikh, Kathy Zink, Mary C. Mccarthy

Department of Surgery Faculty Publications

Although interruptions experienced by nurses during intensive care have been indicated to affect patient safety, not much is known regarding the complex situations that drive interruptions to eventually aid in intervention design and implementation.

Transitions Of Care, Kelly A. Rabah

Obstetrics and Gynecology Faculty Publications

Objectives:

• Define and Describe the various points of transition of care

• Define and Describe the potential risks for TOC

• Articulate the value of interdisciplinary team planning

• Demonstrate an effective patient hand-off via role play.

Creating An Exceptional Patient Experience, Kelly A. Rabah, Nada Elmagbari

Obstetrics and Gynecology Faculty Publications

The patient's experience affects:

• Reimbursement
• Market Share
• Readmission
• Compliance
• Liability and M&M

Common Living Situations With Older Patients: Balancing Support With Independence, Kelly A. Rabah

Obstetrics and Gynecology Faculty Publications

Objectives:

1. Understand and discuss common challenges with aging patients that impact safety, independence and quality of life.

2. Describe how to assess for safety in living environment as well as what resources are available to support patient/family.

3. Know how to identify caregiver challenges, stress, and risk.

4. Understand the importance of addressing and documenting concerns and challenges, while being supportive and offering resources to promote QOL and Independence.

Analyses Of Endothelial Cells And Endothelial Progenitor Cells Released Microvesicles By Using Microbead And Q-Dot Based Nanoparticle Tracking Analysis, Jinju Wang, Yun Zhong, Xiaotang Ma, Xiang Xiao, Chuanfang Cheng, Yusen Chen, Ifeanyi Iwuchukwu, Kenneth J. Gaines, Bin Zhao, Shiming Liu, Jeffrey B. Travers, Ji C. Bihl, Yanfang Chen

Pharmacology and Toxicology Faculty Publications

Accurate analysis of specific microvesicles (MVs) from biofluids is critical and challenging. Here we described novel methods to purify and detect MVs shed from endothelial cells (ECs) and endothelial progenitor cells (EPCs) by combining microbeads with fluorescence quantum dots (Q-dots) coupled nanoparticle tracking analysis (NTA). In the in vitroscreening systems, we demonstrated that 1) anti-CD105 (EC marker) and anti-CD34 (EPC marker) conjugated-microbeads had the highest sensitivity and specificity for isolating respective MVs, which were confirmed with negative controls, CD41 and CD235a; 2) anti-CD144 (EC marker) and anti-KDR (EPC marker) conjugated-Q-dots exhibited the best sensitivity and specificity for their respective …

The Trend Of Communicable And Non-Communicable Diseases In East African Community (Eac) Countries: Case Study Of Burundi, Rwanda, And Uganda - 1990 To 2013, Emile Shumbusho

Master of Public Health Program Student Publications

Background: In low and middle-income countries (LMICs), non-communicable diseases (NCDs) are rapidly emerging alongside a well-documented persistence of communicable diseases (CDs) in fragile health care systems. In sub-Saharan Africa, chronic NCDs are expected to overtake CDs as the leading cause of death. The aim of this study was to compare mortality rates due to CDs and NCDs between developed countries, developing countries, Burundi, Rwanda, and Uganda from 1990 to 2013.

Methods: A descriptive study with longitudinal and cross-sectional analyses of mortality rates was conducted using the global burden of disease (GBD) study data. Tableau Public 9.3 software was utilized to …

The Use Of Hybrid Educational Method For Trauma Training Among U.S. Air Force Nurses, Karey M. Dufour

Doctor of Nursing Practice Program Projects

Trauma assessment is a core skill for all United States Air Force nurses. However, with the recent withdrawals from Iraq and Afghanistan, there are serious concerns about how Air Force nurses can maintain high-level trauma skills without the frequent exposure and opportunities in which to perform them. Although training affiliation agreements with local civilian trauma centers exist, it is difficult to routinely send nurses to receive training in these facilities due to time constraints. Simulation is a feasible way to provide essential training and allows participants to practice critical skills during reproducible scenarios in a realistic but non-threatening environment. Providing …

Five Rivers Family Health Center Community Health Needs Assessment, Kara Yutzy

Master of Public Health Program Student Publications

Objectives: To conduct a community health needs assessment (CHNA) on the three zip codes around Five Rivers Family Health Center (FRFHC) in order to guide healthcare professionals in creating goals and priorities for needed health services in their health center’s targeted community.

Methods: The investigator gathered zip code specific data from the American Community Survey, Public Health - Dayton & Montgomery County, the Dayton Police Department, and other online sources for the FRFHC CHNA zip codes. Data on the targeted zip codes was compared to data from Montgomery County, Ohio, and the United States.

Results: The greatest disparities between the …

Residency And Fellow Participation In Root Cause And Intensive Analysis 2015-16, Kelly A. Rabah

Obstetrics and Gynecology Faculty Publications

The purpose of this document is to familiarize you with two processes that help with quality improvement known as a root cause analysis and an intensive analysis. Further, to explain your role in the process and the importance of your active participation.

Objectives:

• To understand the difference between a root cause and intensive analysis and be able to articulate when each would be appropriate.

• To learn about the importance of patient safety and quality through participation in these processes.

• To gain appreciation and insight into the importance of your role in examining medical and system errors as …

The Influence Of Age At Menarche And Hamstrings Fatigue On Knee Biomechanics, Stephanie Eileen Field

Browse all Theses and Dissertations

Anterior cruciate ligament (ACL) injury is 4-8 times more likely to occur in females than in males and is associated with significant morbidity. The mechanism underlying the gender disparity in non-contact ACL injuries is likely multifactorial, and may be influenced by a variety of risk factors. This study examines the influence of age at menarche and neuromuscular fatigue of the hamstrings muscles on knee biomechanics. Twelve female athletes performed drop vertical jump (DVJ) tasks before and after a fatiguing protocol utilizing a glute-ham bench. Knee kinematics and kinetics were recorded during the contact phase of the DVJ. The results of …

The Association Between Secondhand Smoke Exposure And Metabolic Syndrome In Children With Elevated Bmi, Alexandra Lawson

Master of Public Health Program Student Publications

Background & Purpose: The childhood obesity epidemic is associated with increased metabolic syndrome (MetS) and cardiovascular morbidity. The purpose of this study was to determine whether secondhand tobacco smoke exposure (SHSe) is associated with MetS in children with elevated body mass index (BMI).

Method: A retrospective chart review was conducted on children aged six to 11 years with elevated BMI seen in a pediatric lipid clinic from 2008-2014. Data included age, sex, race, BMI, and five MetS criteria. MetS was defined as BMI ≥85th percentile and ≥two of the following: systolic or diastolic blood pressure ≥90th percentile, HDL/dL, triglycerides >150 …

Medical Professionalism And Enculturation Of The Millennial Physician: Meeting Of The Minds, Steven R. Lindheim, Parvaneh K. Nouri, Kelly A. Rabah, Jerome L. Yaklic

Obstetrics and Gynecology Faculty Publications

The conceptualization of medicine as a profession that was held to ethical and practical standards was first formalized through the writings of 18^th century British physician-ethicists Gregory and Percival. This was in response to the lack of standardization in both training and practice that existed within medicine at the time. Percival’s Medical Ethics subsequently served as reference for the first Code of Medical Ethics issued by the American Medical Association (AMA) in 1847. Today, it is universally accepted that an important aspect of becoming a physician is the learning and implementing of high standards of medical professionalism into practice. …

Examining The Relationship Between Adequate Sleep, Sleep Behaviors, And Psychological Distress In College Students, Neil Knight

Master of Public Health Program Student Publications

Objective: Examine the relationship between sleep hygiene behaviors, overall distress, and total hours of sleep in a college population. The predictors analyzed were: sleep quality, total hours of sleep, level of distress, bedtime, wake time, time to fall asleep, alcohol/drug use, exercise, caffeine consumption and grade point average.

Methods: A retrospective chart review gathered client information from the CCAPS-34 questionnaire and the Standardized Data Set (SDS), obtained by Counseling and Wellness Services at Wright State University. ANOVA determined statistically significant relationships between the variables.

Results: Seven-hundred sixty-seven charts were reviewed. The majority of students included in the study were white …

Immigrants And Refugees As Vulnerable Populations: Considerations For School Based Health Centers, Gaïa D. C. Oliver

Master of Public Health Program Student Publications

School based health centers (SBHC) have been shown to benefit domestic populations both in terms of bettering health and bettering academics while being effective over the long term. There is, however, lacking evidence on how they impact immigrant and refugee communities, which are some of the most vulnerable United States communities in terms of health risks. Through discussion of literature, this paper defines and reviews the criteria for vulnerable populations and explains how this term applies to immigrant and refugee populations. School based health centers and their documented health and academic benefits for domestic high risk populations are discussed and …

From Their Home To Ours: Establishing Environmental And Health Literacy Via Urban Gardening For At-Risk Youth, Tiffany B. Hunter

Master of Public Health Program Student Publications

The Global Health concentration of the Master of Public Health highly encourages its students to participate in efforts which promote health and prevent disease either for a cultural group abroad or with a local disparate group (e.g. first-generation immigrants, established minority groups). The current research aimed to develop a similar model of community engagement and health promotion within an urban setting as witnessed in a developing country.

During an internship with Israel’s Ministry of Health, I witnessed a successful community garden and environmental education program designed for children whom reside in an Arab village. Much like the Israeli Arab community …

Application Of Medical Student Research Objectives In An International Medical Elective: Voluntary Medical Male Circumcision In Swaziland, Alison M. Bales, David J. Dennis, Robert C. Siska, Michael A. Schneider, Echo Vanderwal, Harry Vanderwal, Mary C. Mccarthy

Department of Surgery Faculty Publications

No abstract provided.

A Century Of Morphological Variation In Cyprinidae Fishes, Stephen J. Jacquemin, Mark Pyron

Biological Sciences Faculty Publications

Background

Aquatic habitats have been altered over the past century due to a variety of anthropogenic influences. Ecomorphology is an area of aquatic ecology that can both directly and indirectly assess the effects of habitat alterations on organisms. However, few studies have explored long term trends in morphological variation. Long term changes in morphology can potentially impact niche and ultimately contribute to organismal success and the ecosystem. Therefore, in this study we assessed long term morphological variation with body size, sex, time, and hydrology using museum collections of five species of Cyprinidae (Minnows) from lentic and lotic systems over the …

Preoperative Incidence Of Penile Abnormalities Found During Voluntary Male Medical Circumcision In Swaziland, Anthony R. Oddo, Elizabeth Ruedrich, Christopher Zust, Lindsey Marugg, Echo Vanderwal, Rebekah Sartori, Mary C. Mccarthy

Department of Surgery Faculty Publications

No abstract provided.

Utilizing Social Media To Educate School Nutrition Professionals, Ashley Seybold

Master of Public Health Program Student Publications

Background: Schools enrolled in United States Department of Agriculture (USDA) Team Nutrition (TN) projects often have positive outcomes and develop useful resources. The challenge was to find an accessible mean to share outcomes and resources with schools across Ohio.

Purpose: The purpose of this project was to design a blog to educate school nutrition professionals and build awareness of positive activities related to Ohio school meals. This project also aimed to identify indicators of engagement, make recommendations for research and practice, and identify a set of best practices for future blog site use. Methods: The foundation of the blog ( …

Incorporating Pharmacodynamic Considerations Into Caffeine Therapeutic Drug Monitoring In Preterm Neonates, Tian Yu, Alfred H. Balch, Robert Ward, E. Kent Korgenski, Catherine M.T. Sherwin

Pediatrics Faculty Publications

Background

This study sought to assess the pharmacokinetic and pharmacodynamic relationships of caffeine citrate therapy in preterm neonates who had therapeutic drug monitoring (TDM) in the post-extubation period.

Methods

A retrospective observational study was conducted in preterm neonates who received caffeine citrate therapy for apnea of prematurity and had TDM done in the post-extubation period between January 2006 and October 2011. The relationships between pharmacodynamic effects (heart rate, respiratory rate, episodes of apnea, adverse events) and caffeine serum concentrations were explored.

Results

A total of 177 blood samples were obtained from 115 preterm neonates with a median (range) gestational age …

Uvb Generates Microvesicle Particles Via Platelet-Activating Factor-Receptor Signaling: A Novel Pathway By Which A Skin-Specific Stimulus Exerts Systemic Effects, Jeffrey B. Travers, Christine M. Rapp, Katherine E. Fahy, Christina E. Borchers, Richard Simman, Langni Liu, Yanfang Chen, Ji C. Bihl

Pharmacology and Toxicology Faculty Publications

Though Ultraviolet B radiation (290-320 nm; UVB) exerts profound systemic effects, it is absorbed only in the epidermis. One important question in photobiology is how UVB signals are emanated from the epidermis. Microvesicle particles (MVP) are small (200-1000nm diameter) membrane-bound vesicles released by numerous cell types and can be found in the circulation. MVP can contain both nuclear and cytoplasmic components and are thought to provide a mechanism by which cells transmit signals systemically. Though various stressors have been demonstrated to generate MVP, the ability of UVB to exert this effect has not been demonstrated. Previous studies from ours and …

The Novel Methods For Analysis Of Exosomes Released From Endothelial Cells And Endothelial Progenitor Cells, Jinju Wang, Runmin Guo, Yi Yang, Bradley S. Jacobs, Suhong Chen, Ifeanyi Iwuchukwu, Kenneth J. Gaines, Yanfang Chen, Richard Simman, Guiyuan Lv, Keng Wu, Ji C. Bihl

Pharmacology and Toxicology Faculty Publications

Exosomes (EXs) are cell-derived vesicles that mediate cell-cell communication and could serve as biomarkers. Here we described novel methods for purification and phenotyping of EXs released from endothelial cells (ECs) and endothelial progenitor cells (EPCs) by combining microbeads and fluorescence quantum dots (Q-dots®) techniques. EXs from the culture medium of ECs and EPCs were isolated and detected with cell-specific antibody conjugated microbeads and second antibody conjugated Q-dots by using nanoparticle tracking analysis (NTA) system. The sensitivities of the cell origin markers for ECs (CD105, CD144) and EPCs (CD34, KDR) were evaluated. The sensitivity and specificity were determined by using positive …

Amikacin Pharmacokinetics In Pediatric Patients With Burn Injuries Compared To Those With Oncology Conditions, Xiaoxi Liu, Anne Smits, Tian Yu, Stephanie Wead, Alice Neely, Richard J. Kagan, Daniel P. Healy, Karel Allegaert, Catherine M.T. Sherwin

Pediatrics Faculty Publications

Physiologic changes due to disease status can lead to highly variable pharmacokinetics (PK) of amikacin in children. Therefore, considerations should be given when determining optimal amikacin does for patients with a specific diseases. Improved understanding of factors influencing PD can allow for the optimizing of dosage regimens to reduce adverse effects.

The aim of the study was to undertake a comparative pharmacometic analysis of amikacin use in pediatric patients with burn injuries verses those with oncology conditions.