Medicine and Health Sciences Commons^™

Electromyographic Activity Of Masticatory Muscles In Asymptomatic Young Adults, Aneta Wieczorek, Malgorzata Pihut, Jolanta E. Loster

Journal of Dentistry Indonesia

Introduction: The masseter and the anterior part of the temporalis are the muscles mainly responsible for the clenching function. Clenching patterns and the activity of these muscles are not expected to differ between male and females, nor between different occlusal classes. Objective: The aim of this study was to determine whether the activity index of the masseter and temporalis muscles is related to occlusal class and gender. Methods: This study involved 145 eighteen-year-old Caucasian volunteers who underwent surface electromyography. The sEMG was analyzed at the moment of 100% occlusal contact. Occlusal classes were determined used plaster casts. …

Fractal Analysis Of Subchondral Cyst At Mandibular Condyle Detected On Panoramic Radiograph In A Group Of Thai Population, Aloysius Putut Wijanarko, Preeyaporn Srimawong, Suchaya Pornprasertsuk-Damrongsri, Apirum Janhom

Journal of Dentistry Indonesia

Objectives: This study aimed to analyze subchondral cyst on the mandibular condyle using fractal dimension (FD) measurement on a panoramic radiograph. Methods: This retrospective study examined 15 patients aged 24 to 75 years who had undergone panoramic radiography and cone-beam computed tomography on both sides of the mandibular condyles, between January 2013 and November 2017, in the Oral and Maxillofacial Radiology Clinic, Dental Hospital, Mahidol University. These 15 patients, all of whom had a subchondral cyst on one side of the mandibular condyle, constituted both the study and control groups: the 15 affected sides constituted the study group, …

The Effect Of Disc Displacement On Temporomandibular Joint Morphology In Patients With Disc Displacement, Melike Yurttaş, Esin Bozdemir, Şehnaz Evrimler

Journal of Dentistry Indonesia

Objective: To examine the morphological properties of temporomandibular joint structures by magnetic resonance imaging (MRI) on patients with and without disc displacement (DD). Methods: Thirty-eight patients with disc displacement and 13 patients without disc displacement were included. Age, gender, and clinical findings such as pain, joint sounds of patients were recorded. The patients were classified as anterior disc displacement with reduction (ADDWR) group, anterior disc displacement without reduction (ADDWoR) group, and control group on MRI. Disc morphology was categorized as biconcave, hemiconvex, biconvex, biplanar, or folded. Condyle morphology was characterized as convex, angled, flat, or rounded. Articular eminence …

The Effect Of Melatonin On Implant Stability And Marginal Bone Level Around The Implant, Hemanth Ravella, Mulpuri Venkata Ramoji Rao, Sathish Manthena, Suneetha Koneru, Penubolu Lakshmi Preethi, Venkata Naga Sri Harsha Anumolu

Journal of Dentistry Indonesia

Dental implants have been used for missing teeth replacement with a high success rate. Melatonin is an antioxidant and acts as a free radical scavenger. It retards the resorption of bone by regulating RANKL and OPG synthesis, and increases the BIC (Bone to implant contact) and also bone perimeter and bone mineralization. Objective: The aim of the study was to assess if topical melatonin application at the osteotomy site has any influence on the stability and marginal bone level around the implant Methods: In this split mouth double blind randomized control trial 30 implants were placed on either …

Selection Of Commercially Available Membrane Between Resorbable And Nonresorbable Materials For Guided Bone Regeneration, Yunia Dwi Rakhmatia, Yasunori Ayukawa, Akihiro Furuhashi, Kiyoshi Koyano

Journal of Dentistry Indonesia

Objective: This study aims to evaluate the commercially available membranes used for treatment in Guided Bone Regeneration (GBR). Methods: Four membranes resorbable and non-resorbable were used and a critical size defect in six-week-old Wistar rats was created for membrane application. Meanwhile, the defect without membrane treatment was used as the control (C). Results: After 4 and 8 weeks, all rats were euthanized and block biopsies of calvaria including membrane were excised and analysed using microcomputed tomography (micro-CT). The sections were dehydrated with graded ethanol, embedded in resin, and cut for histologic evaluation. After 4 weeks, all membrane …

The Practices Of Treating Deep Carious Lesions Compared With The Dental Curriculum In Turkish Dentistry, Leyla Kerimova, Erdem Karabulut, Kivanç Yamanel, Neslihan Arhun

Journal of Dentistry Indonesia

Objective: The aim of this cross-sectional study is to investigate Turkish dentists’ opinions and preferences regarding the management of deep carious lesions and compare them with modern dental education concepts as provided by dental schools. Methods: Questionnaire 1 and Questionnaire 2 were sent separately to dental practitioners via the Turkish Dental Association and to university department heads of restorative dentistry. The data obtained were analyzed using chi-square tests and one-way ANOVA tests (p < 0.05). Results: Regarding Questionnaire 1, most of the dentists (89.3%) responded that caries lesions should be removed completely up to the hard cut-off condition of …

Uncut Enamel For Optimizing Bonded Composite Restoration On Multiple Diastema Closure Cases, Citra Kusumasari, Meiken Hayashi, Yasushi Shimada

Journal of Dentistry Indonesia

The main advantage of using a minimal invasive strategy concept by uncut enamel technique while doing direct composite restoration is to create a color and translucency close to the natural teeth with long-term bonding durability. Objective: This case report presents an uncut enamel technique for multiple diastema closure cases using direct composite restoration. Case Reports: an 18-year-old male and a 50-year-old female patient complained of diastema in their upper front teeth and requested aesthetic correction. Digital mock-up was made prior to the uncut enamel technique for showing the expected results to the patient and as a guidance for the …

Critical Evaluation Of Failed Maxillary Resin Bonded: A Case Study, Yew Hin Beh, Azirrawani Ariffin

Journal of Dentistry Indonesia

Resin bonded bridge (RBB) is a conservative, medium to long-term restoration of missing teeth. A high rate of debonding was the main limitation in a clinically demanding situation. Objective: To highlight the critical evaluation in identifying the contributing factors leading to the failure of RBBs and avoiding as well as controlling such factors optimally prior to providing further rehabilitative treatment. Case report: This case illustrates a young patient who received resin bonded bridges to replace her missing lateral incisors. Unfortunately, she had issues with bridge debonding, in which one of the abutment teeth was extracted due to caries …

The Impact Of The Labial Flange And Artificial Teeth On Lip Support In Elderly Patients With Maxillary Complete Dentures, Aiemeeza Rajali, Nor Wati @ Nur Atikah Mustafa, Muhamad Zafir Ashman Zulkiflee, Ain Najihah Abd Rahman, Rohana Ahmad

Journal of Dentistry Indonesia

Both maxillary complete denture’s labial flange and anterior artificial teeth play important roles in re-establish major support for the upper lip of elderly patients. However, whether the labial flange can be removed and still perceived as aesthetic remain unclear. Objective: To determine the perception of young adults toward the effect of a labial flange and anterior teeth on lip support of an elderly with maxillary complete dentures. Methods: A total of 64 young adults were recruited to evaluate the lip support for facial aesthetics of 30 full-face photographs in 3 different states: with an original complete denture (CD), …

Iatrogenic Extrusion Of Calcium Silicate Cements On Teeth Associated With Large Periapical Lesion: A Case Report With 12-Month Follow-Up, Afiq Azizi Jawami, Eason Soo

Journal of Dentistry Indonesia

Traumatic dental injuries can result in pulp necrosis and apical periodontitis, impairing root development. When this condition is left untreated, it causes inflammation in the tissues at the apex, which may lead to significant damage of the periapical alveolar bone. Tooth with open apex may have a risk of iatrogenic error of extrusion material during the stage of root canal obturation. Objective: This case report discussed the bone healing of large periapical lesion of an iatrogenic extrusion of calcium silicate cement in an open apex maxillary left central incisor. Case report: A 35-year-old female patient presented with a …

Pharmacy Performance Based On Financial Perspective Before And During Covid-19 Pandemic : A Case Study, Eva Sartika Dasopang, Ida Fauziah, Fenny Hasanah, Desy Natalia Siahaan, Dina Yunisma Rasyida Lubis

Pharmaceutical Sciences and Research

A pharmacy, aside from being a pharmaceutical care provider is also a functioning business. Thus, in the scope of business, pharmacy performance can be analysed using liquidity, activity, and profitability ratios. This study aimed to determine the performance of Pharmacy X based on a financial perspective before and during the COVID-19 pandemic. This research is a descriptive cross-sectional study that employed data obtained from sales and purchase records. The data were analysed using financial ratio analysis methods, including liquidity, activity, and profitability ratios. This study was conducted at Pharmacy X based on the amount of prescription and non-prescription income from …

Effects Of Lime (Citrus Aurantifolia Swingle) Peel Extract Addition To Periodontal Dressing On The Number Of Blood Vessels In The Gingival Wound Healing Process, Malianawati Fauzia, Savira Pratista Oktaviana

Journal of Dentistry Indonesia

Background: Periodontal dressings that are currently available can only protect wounds from mechanical trauma, but have no ability to accelerate wound healing. Lime (Citrus aurantifolia Swingle) peel extract added to periodontal dressing contains flavonoids which can stimulate the formation of new blood vessels, thus accelerating the healing process. Objective: To determine the effects of adding lime (Citrus aurantifolia Swingle) peel extract to periodontal dressing on the number of blood vessels in the gingival wound healing process. Methods: 32 rabbits with 2 mm wound made on the gingiva were divided into 8 groups. For the control groups of …

Primary Oral Myiasis Of Anterior Maxilla In An Intellectually Disabled Female – A Case Report, Sridhar M, Shivayogi Charantimath, Anjana Bagewadi, Lokesh Kumar S, Arun Panwar, Jayapriya T, Vaishali Keluskar

Journal of Dentistry Indonesia

“Myiasis” is a term used to represent invasion caused by fly larvae that affect organs and tissues of human beings and feeds on the host tissue. It is a rare and non-specific pathology that varies according to the species of fly larvae and the area of the body involved. Various factors like extraction wounds, uncontrolled diabetes, necrotic tissues, alcohol addiction, poor oral hygiene, immunocompromised conditions and people with special care needs like debilitated or mentally challenged individuals predispose to develop myiasis. We hereby report a case of oral myiasis of the maxillary anterior region of the palate and labial mucosa, …

Structural Elucidation And Toxicity Evaluation Of Bioactive Compounds From The Leaves And Stem Woods Of Synadenium Glaucescens Pax., David Credo, Faith Philemon Mabiki, Francis Machumi, Claus Cornett

Pharmaceutical Sciences and Research

The leaves and stem woods of Synadenium glaucescens Pax. are traditionally used for treatment of various human diseases in Tanzania. However, there is limited information on the structural elucidation and toxicity properties of bioactive compounds responsible for their pharmacological properties. Thus, this study was aimed to elucidate and evaluate toxicity properties of bioactive compounds from these parts. Separation of bioactive compounds was achieved by using column chromatographic method, whereas their structures were determined by GC-MS and NMR data and by comparing with literature spectroscopic data. Toxicity properties of isolated compounds was done by brine shrimp lethality test (BSLT) method. In …

The Association Between Adherence To Oral Antihyperglycemic Agent And Hba1c Level, Indana Ayu Soraya, Rani Sauriasari, Pukovisa Prawiroharjo, Hindun Wilda Risni

Pharmaceutical Sciences and Research

Adherence to taking medication is essential for patients with chronic diseases such as Type 2 Diabetes Mellitus (T2DM). There have been many studies about the association between medication adherence and HbA1c levels, but few have used Adherence Refills and Medications Scale (ARMS) questionnaire and Proportion of Days Covered (PDC) method to measure adherence in Indonesian population. The aim of this study were to assess the association of medication adherence to HbA1c levels and compare two methods of adherence measurements. This research was conducted at Pasar Minggu Public Health Center, Jakarta using a cross-sectional design. The adherence assessment was conducted using …

Qualitative Evaluation Of Antibiotics Use With Gyssens Method In Sepsis Patients At Fatmawati Central General Hospital Jakarta, Mas Masyrifah, Retnosari Andrajati, Linda Triana Yudhorini

Pharmaceutical Sciences and Research

Sepsis still becomes a major health problem worldwide, with a fairly high mortality rate ranging from 20 to 50%. Antibiotic therapy with rational use can reduce the mortality rate. In contrast, the irrational use of antibiotic therapy will increase the occurrence of resistance, which impacts the increase of morbidity, mortality, and health costs. The objective of this study was to evaluate the quality in the use of antibiotics using the Gyssens method in patients with sepsis. This study was an observational study with a cross-sectional method conducted at Fatmawati Central General Hospital Jakarta from January to December 2020. The research …

Discovery Of Sars-Cov-2 Rna-Dependent-Rna-Polymerase (Rdrp) Inhibitor From Sambiloto (Andrographis Paniculata) Based On Molecular Docking And Admet Prediction Approach, Dina Ahsana, Rizki Rahmadi Pratama, Alfisyahriatunnida Meily, Andika Andika

Pharmaceutical Sciences and Research

The rapid spread of the coronavirus disease 2019 (COVID-19) has led to the development of therapeutic inhibitor drug of SARS-CoV-2, which can inhibit the viral enzyme RNA-dependent-RNA-polymerase (RdRp), thereby preventing the replication, transcription, and synthesis of RNA virus in the host cells. Previous in-vitro studies revealed that Andrographis paniculata has the potential to inhibit the virus. Therefore, this study aims to isolate the specific compounds of Andrographis paniculata, which play a role in inhibiting SARS-CoV-2 RdRp using molecular docking. A total of 19 compounds were identified in previous literature studies, while remdesivir and favipiravir were used as the positive …

Phytochemical Analysis, Antioxidant And Anticancer Effects Of Clitoria Ternatae Extract On Breast T47d Cancer Cells, Ade Arsianti, Shahjahan Pasha Mahindra, Norma Nur Azizah, Ajeng Megawati Fajrin, Lince Dameria Nadapdap

Indonesian Journal of Medical Chemistry and Bioinformatics

Background: Breast cancer is one of the most common and deadly forms of cancer in the world. Cancer is a multi-factorial disease. Genetic factors, environment and lifestyle have a role in the development of cancer. One of the mechanisms of cancer development is when an imbalance between free radicals and antioxidants in the human body occurs. Uncontrolled and excessive amount of free radicals and cause cell damage and uncontrolled cell growth. Clitoria ternate is a plant that is often found in Asia and many of the benefits of this flower have been studied. This study aims to determine the phytochemical …

Phytochemical Screening And In-Vitro Α-Glucosidase Inhibitory Activity Analysis Of Ethanol Extract Of Mangifera Quadrifida, Fadilah Fadilah

Indonesian Journal of Medical Chemistry and Bioinformatics

Abstract

Introduction: Type 2 Diabetes Mellitus (DM) is a metabolic disorder characterized by hyperglycemia caused by B cell dysfunction, insulin resistance, or both. Indonesia and worldwide have an increasing incidence that leads to a significant socio-economic burden. The effective treatment of Type 2 DM with minimal side effects is still challenging. This research aims to identify phytochemical properties in ethanol extract of Mangifera quadrifida and the effectivity as an alfa-glucosidase inhibitor beneficial to research on the treatment of type 2 DM.

Method: Mangifera quadrifida was extracted by ethanol as solvent. The phytochemical analysis is conducted by phytochemical screening methods and …

Pharmacophore-Based Virtual Screening From Indonesian Herbal Database To Find Putative Selective Estrogen Receptor Degraders, Aisyah F. Prawiningrum, Rafika Indah Paramita, Linda Erlina

Indonesian Journal of Medical Chemistry and Bioinformatics

Most breast cancer cases are luminal subtypes which are estrogen receptor-sensitive or progesterone receptor-sensitive. Common treatments include surgery and adjuvant endocrine therapy by prescribing selective estrogen receptor degraders (SERD). SERD is a type of medication that inhibits estrogen receptor (ER) activity by degrading it, and as a result, downregulating it. The current FDA-approved SERD can only be administered through intramuscular injection. The aim of this study is to find orally non-toxic and bioavailable herbal alternatives of SERDs in Indonesian Herbal Database by doing virtual screening using LigandScout. The hit compounds were further analyzed using a molecular docking tool, AutoDock. Three …

Analysis And Visualization Of Molecular Docking 2hi4 Protein, Innas Widiasti

Indonesian Journal of Medical Chemistry and Bioinformatics

The crystal structure of the human microsomal complex P450 1A2 with alpha-naphthoflavone, a cytochrome P450 (CYP) enzyme is particularly important, as it is abundant in the human liver and alters a more diverse xenobiotic array than any other group of metabolic enzymes. CYP1A2 is abundantly found in the liver and involved in the metabolism of about 10% of clinically used drugs metabolized by CYP enzymes. The current drug discovery and development mostly uses high-throughput screening (HTS). However, this regular method is time-consuming and costly. To address the issue, an advanced drug discovery and development method namely chemical compound database screening …

Molecular Docking Of Vitamin D3 Receptor (Vdr) With Potential Herbal Substance As Ligand To Prevent Excessive Hair Loss In Menopausal Women, Aditya Parawangsa, Syailendra Karuna Sugito, Ariestiana Ayu Ananda Latifa, Nadya Dinda Safira, Shafa Ayuthaya, Raissa Rahmalia Az Zahra

Indonesian Journal of Medical Chemistry and Bioinformatics

Hair loss is commonly found in menopausal women. Hair loss is one of the consequences of hormonal dynamics when a woman stops having menstrual cycle, which affect calcium and vitamin D level in the body. Although it is clear enough that hormonal adjustment is required, older people and another sociodemographic factor prefer herbal-based therapeutic rather than synthetic-based due to tradition and positive experience factors. This study is an in-silico study which aims to point out the possible ligand candidates that can work as Vitamin D Receptor (VDR) agonists. We perform molecular docking using Autodock version 4.2 with the criteria of …

Hubungan Antara Faktor Individu Dan Terjadinya Kelelahan (Fatigue) Pada Pekerja Kantor Di Masa Transisi Pandemi Ke Endemi Covid-19, Maghfira Hernayanti, L. Meily Kurniawidjaja, Nova Amalia Sakina

National Journal of Occupational Health and Safety

The Covid-19 pandemic has changed almost all aspects of human life, including the workforce. The Work from Home (WFH) policy causes irregular working hours. This causes fatigue in workers during the transition from the pandemic to the Covid-19 endemic. Many factors cause work fatigue to occur, one of which is individual factors. This study aims to determine the correlation between individual factors (family social life, sleep quality, sleep quantity, health disorders, psychological, and unhealthy behavior) with the occurrence of fatigue in office workers during the transition from the pandemic to the Covid-19 endemic. Data collection was carried out by disctributing …

Analisis Pengaruh Faktor Personal Dan Faktor Organisasi Terhadap Perilaku Tidak Selamat Pada Pekerja Konstruksi, Gavin Andre Irhandy, Dadan Erwandi

National Journal of Occupational Health and Safety

Construction industry has a high hazard and high risk to allow work accident. The purpose of this study was to analyze the effect of individual risk factor and organizational risk factor associated with unsafe behavior or substandard action in construction workers. This study used a cross sectional study design. The instrument used for collecting data and this research conducted in Mei – July 2021 involving 165 workers in the sports center stadium construction project Banten. The result of this research indicate age has a positive effect but not significant against unsafe behavior or substandard action. While education level, work experience …

Gambaran Faktor Psikososial Dan Gejala Stres Kerja Pada Karyawan Kantor Proyek Pembangunan X, Vania Widyadhari Haris Putri, L. Meily Kurniawidjaja

National Journal of Occupational Health and Safety

This study aims to describe the perception of workers on psychosocial factors and to find out the symptoms of occupational stress among the staff. The dependent variables are occupational stress symptoms, while the independent variables are individual characteristics, context to work, and content of work. The research design is cross sectional, using online questionnaire and involving all 51 employees. Univariate analysis is using computer software. Perception of psychosocial factors refers to the average score, 1.00-3.00 is poor and 3.01-5.00 is good. The results showed psychosocial factors in context to work were perceived as poor, namely decision latitude and control (2.92) …

Analisis Faktor Risiko Keluhan Subjektif Gangguan Muskuloskeletal (Msds) Pada Guru Dan Murid Sma Akibat Pembelajaran Jarak Jauh Di Bogor, Heykal Aldaffa Azizie, Indri Hapsari Hapsari Susilowati

National Journal of Occupational Health and Safety

The COVID-19 pandemic has forced many community activities to be limited, including the education aspect in Indonesia, which implements online learning (PJJ). This online learning makes all learning activities being online and requires teachers and students to be in front of their gadgets to carry out online learning. This PJJ activity certainly has an ergonomic risk that causing musculoskeletal disorders (MSDs). This study aims to determine the risk of ergonomics during online learning activities for high school teachers and students in Bogor. The method in this study is a cross-sectional study design using the Nordic Musculoskeletal Questionnaire and additional questionnaire …

Analisis Hubungan Faktor Fisik Dan Psikososial Terhadap Keluhan Gangguan Otot Tulang Rangka Akibat Kerja Pada Guru Smk Negeri Di Kota Pekanbaru, Maria Yolanda Florensia, Baiduri Widanarko

National Journal of Occupational Health and Safety

Work-related musculoskeletal disorders (WMSDs) are one of the most common occupational health problems among workers, including teachers. High work demand and awkward posture are among the most common risk factors. In addition, individual characteristics are included as risk factors that can increase these complaints. Thus, the purpose of this research is to analyze the relationship between individual characteristics, physical and psychosocial risk factors against WMSDs on teachers at State Vocational High School. This research was conducted in April – July 2021 using various questionnaires like NMQ, QEC, and a combination of psychosocial questionnaires. A cross-sectional study design was used in …

Analisis Faktor Risiko Ergonomi Terhadap Keluhan Gangguan Muskuloskeletal Pada Pekerja Umkm Pengrajin Alas Kaki Di Kecamatan Ciomas, Dita Mayasari, Indri Hapsari Hapsari Susilowati

National Journal of Occupational Health and Safety

Work activity on footwear Micro, Small, and Medium Enterprises (MSMEs) such as sitting work position, bending down, neck bend, long duration of work and uncertain can cause pain that lead to musculoskeletal disorder complaint. This research aim to analyze individual risk factors, occupational risk factors, work environment risk factors, and work equipment risk factors against musculoskeletal disorder complaint on footwear MSMEs workers in Ciomas district. This research using cross sectional study design. The result of the research showed that 84,7% of respondent have a musculoskeletal disorder complaint. On some risk factors researched, there was a significant relationship between individual risk …

Control Of Scabies In A Boarding School Using 5% Permethrin Applied On Lesion Only, Saleha Sungkar, Sri Wahdini, Aria Kekalih, Risa Rilanda, Hansen Angkasa, Sandra Widaty

ASEAN Journal of Community Engagement

Scabies is one of the most neglected tropical skin diseases in Indonesia. It is usually found in overcrowded communities with poor hygiene. The gold standard for scabies treatment is the whole-body topical application of 5% permethrin cream. However, the treatment causes inconvenience and stickiness for a prolonged period. The modification of topical treatment by applying only to the lesion yielded results similar with whole-body topical application. We consider using this mode of treatment to control the disease in a boarding school. The study was conducted from June to August 2019. All students were examined by dermatologists, and individuals who were …

Increasing Rosella Farmers Capacity By Double Diamond Design Thinking Approach, Florence Pribadi, Muliasari Kartikawati, Juli Karijati Njoto, Nurul Illahi Kusuma Sari, Farah Shania Nur

ASEAN Journal of Community Engagement

Rosella (Hibiscus sabdariffa Linn) is a well-known family medicinal plant (Toga). Spoilage due to the weather, and the consequent low revenue gained from selling dried rosella are two of the main challenges currently being encountered by rosella farmers. Regardless of previously practicing community engagement including regular training from local authorities, farmers are still encountering difficulties to implement the training materials, consequently experiencing loss. Method incorporated in this community engagement is the double diamond design thinking that ensures putting the farmers first in all stages. Method chosen for drying rosella was a mixed solar dryer equipped with heating lamps …