Medicine and Health Sciences Commons^™

The Influences Of Medical Students' Consent To Participate In Thalassemia Research, Raditya Wratsangka, Donna Adriani, Endrico Xavierees Tungka, Aditya Krishna Murthi

Kesmas

An effective way of learning about thalassemia, a complex public health issue with multiple perspectives, is through participating in research. This study used an inductive approach to presume the influencing factors of students' consent to participate in thalassemia research voluntarily. Nested in the preliminary stage of a research series on thalassemia, this study used a consecutive sampling to recruit 140 medical undergraduates. Their knowledge, experience, and attitude to thalassemia and the perception of self-quality life were assessed using self-administered questionnaires. Blood samples were drawn for carrier screening. Students' GPAs were collected from faculty records. Of 140 participants, only 123 had …

Performance Of Stunting Reduction Acceleration Team: An Explorative-Qualitative Study In Indonesia-Timor Leste Border Area, Maria Paula Marla Nahak, Veronika Nitsae

Kesmas

Stunting is a complex issue influenced by multiple factors, including specific factors within and outside the health sector. Achieving a significant reduction in stunting needs the involvement of relevant local government offices in the Stunting Reduction Acceleration Team (SRAT). This study aimed to investigate SRAT performance in a specific context of accelerating stunting reduction in Malaka District. This qualitative study, with a phenomenological approach, was conducted in Malaka District, Indonesia, and Timor Leste Border Area from July to September 2023. This study revealed four major themes of SRAT performance to accelerate stunting reduction in Malaka District: activities to accelerate stunting …

Spatial Durbin Model On The Utilization Of Delivery At Health Facilities: A 2017 Indonesian Demographic And Health Survey Analysis, Indah Sri Wahyuni, Ira Gustina, Martya Rahmaniati Makful, Tris Eryando

Kesmas

The utilization of delivery at health facilities is a major intervention in reducing 16 to 33% of deaths. This study aimed to determine the model of utilization of delivery at health facilities in Indonesia in 2017 and its influential factors. This study used secondary data from the 2017 Indonesian Demographic and Health Survey using a Spatial Durbin Model (SDM) approach. The population was mothers aged 15 – 49 years, spread across 34 provinces of Indonesia, and had 15,321 samples. The results showed that the Moran’s I value was positive (0.146) and significant at p-value = 0.007, indicating clustered regions with …

Mapping For Tracking Sexually Transmitted Infections By Subdistricts In Surabaya, Indonesia, Destri Susilaningrum, Brodjol Sutijo Suprih Ulama, Fausania Hibatullah, Diandra Soja Anjani

Kesmas

The 2014 shutdown localization of prostitution in Surabaya City, East Java Province, Indonesia, has given rise to an illegal prostitution industry, resulting in the spread of uncontrolled sexually transmitted infections (STIs). Mapping needs to be done to track the spread of the disease. This study used secondary data on STIs in 2020 from the Surabaya City Health Office. By using biplot analysis, this study sought to offer a detailed understanding of the distribution and dynamics of STI cases in different parts of Surabaya. The early-stage syphilis was found in Tegalsari and Krembangan Subdistricts; then, gonorrheal urethritis was found in Tandes, …

Exploring The Implementation Of Safety Resilience Assessment In Industries: A Systematic Literature Review, Mufti Wirawan, Fatma Lestari, Zulkifli Djunaidi, Azka Hafia, Agra Mohamad Khaliwa, Muhammad Schehan Al Azhar

Kesmas

Safety Resilience discusses how a work process can run properly not only aims at preventing adverse events, but also increasing work productivity and effectiveness by increasing resilience. The concept of resilience has been widely suggested as safety management due to its ability to support organizations to continue operating even when facing unexpected demands or scale disruptions by improving their day-to-day performance. This study used a systematic literature review to explore the implementation of safety resilience in various industries. The results showed that 50% of articles used the Resilience Assessment Grid instrument to measure safety resilience in the workplace. In brief, …

Menstrual Personal Hygiene Behavior Among Adolescents With Physical And Intellectual Disabilities, Nur Khotimah Elfiyani, Agustin Kusumayati, Caroline Endah Wuryaningsih, Kemal Nazaruddin Siregar

Kesmas

Reproductive health for adolescents with disabilities is often disregarded, and education on personal hygiene is insufficient because some people perceive menstruation as a sensitive topic and have a false belief that adolescents with disabilities have no sexual desire. This study aimed to determine the overview of personal hygiene behavior among adolescents with physical and intellectual disabilities when facing menstruation. The method used was qualitative, with case studies, in-depth interviews, and observations for data collection. The informants comprised four adolescents aged 19-21 years, two mothers, and two therapists for special needs children. This study was conducted at two growth and development …

Exploring The Multifaceted Nature Of Occupational Stress Among Nurses: A Systematic Review, Bala Murali Sundram, Suriya Kumareswaran Vallasamy, Umairah Muhadi

Kesmas

This systematic review examined occupational stress among nurses, its multifaceted nature, and its significant impact on healthcare delivery and nurse well-being globally. This study identified various stressors, including intrinsic job factors, organizational structure, role expectations, interpersonal relationships, and career development. Using the Cooper and Marshall stress model, a thorough literature search was conducted across databases like ISI Web of Knowledge, PubMed, Scopus, Ovid Medline, and Google Scholar, focusing on publications from 2010 to 2023. This rigorous approach included diverse research methodologies, emphasizing studies measuring outcomes related to occupational stress and mental health among nurses. A total of 10 studies met …

Prevention Of Hiv Transmission Among Men Who Have Sex With Men And Compliance With Sexual Protective Equipment, Rico Januar Sitorus, Nurafni Octavia, Merry Natalia Panjaitan, Anita Rahmiwati Rahmiwati, Rizma Adlia Syakurah, Danny Aerosta, Reymart V Sangalang, Yusri Yusri

Kesmas

Sexual orientations, such as gay, lesbian, and bisexual, are prevalent among individuals at high risk of experiencing mental health problems, including drug use, depression, emotional distress, and suicide. Therefore, this study aimed to assess the compliance of men who have sex with men with protective equipment and determine the dominant influential factors. This cross-sectional study included 187 men who had sexual intercourse with men who were recruited from two foundations based in Palembang City, Indonesia, focusing on people living with HIV/AIDS. Data were analyzed using Chi-square and binomial logistic regression. In this context, 50.8% of men who have sexual intercourse …

Analysis Of Factors Affecting Hospital Risk Management In Indonesia: The Sem-Pls Approach, Dihartawan Dihartawan, Fatma Lestari, Baiduri Widanarko, Besral Besral

Kesmas

Healthcare workers, especially those in hospitals, face a variety of complex hazards and exposures. One of the essential aspects of reducing risks and dangers is effective risk management. This study used a cross-sectional approach to survey the implementation of occupational health and safety management systems in Indonesian hospitals and to identify factors predisposing hospital risk management in Indonesia. A purposive sampling method was employed to select 90 hospitals distributed across 10 provinces in Indonesia. Data were analyzed using descriptive analysis, correlation, and SEM-PLS. A total of 44 hospitals (48.9%) had complete status plenary, and the majority were type C hospitals …

Innovation In Bioinformatics: Recent Tools, Database And Involvement Of Artificial Intelligence, Aziz Ahmed, Mohd Shuaib, Abdulbasid Banga, Rizwan Ahmad

Indonesian Journal of Medical Chemistry and Bioinformatics

Bioinformatics has evolved in recent years into a crucial subject and a well-liked research area that is interconnected with many approaches and disciplines. The capacity of bioinformatics and its approaches to tackle challenging biological problems and promote research and development. There are various tools and database which are used in bioinformatics. AI is the capacity of a computational system to carry out various activities associated with intellectual beings and as a computer system's imitation of human intelligence processes. The bioinformatics applications with artificial intelligence have the capacity to annotate the data in the direction of logical conclusions. By combining AI …

Contents Of Vol. 31, No.1, April 2024, Yuniardini Septorini Wimardhani

Journal of Dentistry Indonesia

This is the Cover and the Contents of the Vol. 31 No. 1 2024

Phytochemical Assay And In – Vitro Cytotoxicity Assessment Of Cassava Peel (Manihot Esculenta) From Ethanol And Ethyl Acetate Extract Against Cervical Cancer Cells (Hela), Alice Hari Soejono, Surya Dwira, Puji Sari

Indonesian Journal of Medical Chemistry and Bioinformatics

Introduction: Cervical cancer is a type of cancer that develops in a woman’s cervix. It is a result of HPV (Human Papilloma Virus) and is one of the deadliest types of cancer. Some cervical cancer management including chemotherapy, which until recently continues to develop to cure the condition, is relatively expensive and comes with multiple different side effects.

Method: Manihot esculenta undergoes multilevel maceration with the solvent of ethanol and ethyl acetate. This leads to the formation of ethanol extract and ethyl acetate extract of Manihot esculenta that is analyzed through phytochemical assay and thin layer chromatography (TLC) to determine …

Basic Structure Of The Pharmacophore Virtual Screening Protein 7kg7 For Candidate Therapeutic Options Covid-19, Ahmad Ridha Al Fiqri

Indonesian Journal of Medical Chemistry and Bioinformatics

Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome, namely coronaviruses (SARS-CoV-2) has been a pandemic to date and is contagious with relatively high mortality rates. Various efforts have been made to control the pandemic to finding the best solution to reduce the spread such as rapid detection based on molecular and serological, as well as efforts to find the best medicine for COVID-19 patients continue to be carried out. We analyzed and concluded that the presatovir compound is capable of being a substitute for the native protein ligand 7KG7, this is proved with a ΔG value of -13.22 kcal/mol …

Antioxidant Activities And Protective Effects Of Shorea Macrophylla Leaf And Bark Extracts, Salfarina Ramli, Nik Nor Sabrina Sukri, Nur Adhwa’ Faqihah Zulkifli, Donna Maretta Ariestanti, Chee Yan Choo, Hasseri Halim, Nurhuda Manshoor, Richard Johari James

Pharmaceutical Sciences and Research

Shorea macrophylla, also known as the ‘Engkabang’ tree or Light Red Meranti, is renowned for its role in reforestation efforts. Despite lacking records of traditional use, the reported biological activities of other species within the Shorea genus spark curiosity about the potential biological activities of this plant. Therefore, this study aims to explore the antioxidant capabilities of S. macrophylla leaf and bark extracts, along with their protective effects against oxidative stress using a brine shrimp model. In the evaluation of antioxidant potential, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays were employed. Extracts were incubated in …

Perceptions Of Oral Health-Related Care For Children With Autism Spectrum Disorder: A Scoping Review, Ismail Nabil Albhaisi, Shahida Mohd-Said, Yan Jia Lim, Tuti Ningseh Mohd-Dom, Ahmad Shuhud Irfani Zakaria, Colman Patrick Mcgrath

Journal of Dentistry Indonesia

Objective: This review aimed to seek insights into the challenges faced by caregivers and children with autism spectrum disorder (ASD) when performing and accessing oral care and their recommendations to overcome the matter. Methods: Six electronic databases were used to search for published English full articles using a standardised strategy and grouped using thematic analysis as findings to the study’s goal. Results: The initial screening found 46 relevant articles, but 21 were deemed eligible. Studies were mostly observational (18 crosssectional surveys and 3 case-controls), retrieving data from online or face-to-face surveys and insurance health info. The perceptions …

Investigation Of The Effect Of The Covid-19 Pandemic On Anxiety Levels And Career Satisfaction Of Dentistry Students, Furkan Kır, Ata Batuhan Bayrak, Mediha Büyükgöze-Dindar

Journal of Dentistry Indonesia

Objective: This study aimed to investigate the effect of the COVID-19 pandemic on the anxiety levels and career satisfaction of dentistry students. Methods: A total of 220 dentistry students were included in the study. A questionnaire was mailed to dentistry students at Trakya University between June 2021 and January 2022. Beck Anxiety Inventory (BAI) was used to evaluate anxiety levels. Data were analyzed, and p < 0.05 was considered statistically significant. Results: The mean BAI scores of the participants were 14.6 ± 13.6. The anxiety levels of the females were significantly higher than the males (p = 0.004). There was a significant relationship …

Epidemiology Of Bruxism And Temporomandibular Joint Disorders (Tmd) In Iranian Adults: A Cross-Sectional Study, Parviz Amini, Maryam Sharifi, Reyhane Aftabi, Fatemeh Jahanimoghadam, Hamidreza Jahanimoghadam

Journal of Dentistry Indonesia

Objective: The prevalence of bruxism in the literature has been reported differently. The aim of this study was to assess the prevalence of bruxism in patients aged 25–40 who were referred to Kerman Dental School. Methods: This analytical descriptive cross-sectional study was performed on 320 patients referred to the Department of Oral Medicine of Kerman Dentistry Faculty in the age range of 25 to 40 years old. The prevalence of bruxism as well as TMJ disorders were evaluated. Data were collected in a questionnaire and entered into SPSS version 24. Analyzing was done by a chi-square test at …

Development And Validation Of The Human Aspects Influencing The Oral Healthcare Data Quality (Hai-Dq) Questionnaire Among Primary Oral Healthcare Workers In Malaysia, Alwani Mohd Zuhudi, Syirahaniza Mohd Salleh, Mohd Zulkarnain Sinor, Mohd Zarawi Mat Nor, Basaruddin Ahmad, Sarliza Yasmin Sanusi

Journal of Dentistry Indonesia

Resolving substandard oral healthcare data quality requires identifying the influencing factors. However, no known instrument for such assessment can be used locally. Objective: To develop and validate the HAI-DQ questionnaire for assessing human factors that influence oral healthcare data quality among primary oral healthcare workers in Malaysia. Methods: The HAI-DQ questionnaire was developed based on literature reviews, focus group discussions, and focus observations. Six experts assessed its content validity using the Content Validity Index (CVI), and the Face Validity Index (FVI) was used to establish its face validity through a pre-test involving 30 primary dental personnel. Results: Four …

Effect Of Taper And Pitch On Nickle-Titanium File With Variable Cross Section To Its Cyclic Fatigue (In Silico Study), Yustika Chrysandra, Tunjung Nugraheni, Wignyo Hadriyanto

Journal of Dentistry Indonesia

The geometric design of an endodontic file includes cross-sectional shape, taper, and pitch. NiTi endodontic files of OneCurve (MicroMega) are made of two variations of cross-sectional shape, that is, double-s shaped and triple helix. Various kinds of modifications were made to increase the resistance of the NiTi endodontic files from fracture. Cyclic fatigue is the most common factor that causes a fracture of the endodontic file. Objective: The purpose of this study was to obtain a NiTi endodontic file design that has the best cyclic resistance value based on its taper size and number of pitch. Methods: This …

Comparison Of The Factors Affecting Smile Esthetics With The Patient And Physician Perceptions Using The Smile Esthetic Index, Dilek Özkan Şen, Zeynep Taştan Eroğlu,, Osman Babayiğit,, Fatma Uçan Yarkaç

Journal of Dentistry Indonesia

Objective: This study aimed to evaluate the smile esthetics of individuals and the factors affecting it using the smile esthetic index (SEI) and compare them with the patient’s perception of smile. Methods: Seventy-six patients consisting of 44 females and 32 males who presented to for routine periodontal treatments were included in study. The smile esthetics were evaluated by three researchers on the photographs taken from the patients. The visual analog scala was used for the subjective evaluation of smile esthetics. Results: According to the results obtained from the study, the average of the SEI total scores was …

Effect Of Ultrasonic Combined With Solvent On Gutta-Percha And Bioceramic Sealer Removal In Middle And Apical Third Of The Root Canal: An Ex Vivo Study, Eko Fibryanto, Wiena Widyastuti, Adi Hidayat, Lisiana Hastuty

Journal of Dentistry Indonesia

Objective: This study aims to investigate the effectiveness of ultrasonic tip with and without solvent in removing gutta-perca and bioceramic sealer from the middle and apical third of the root canals. Methods: This is a true experimental study with randomized pretest-posttest control group design. Eighteen freshly extracted straight single-rooted mandibular first premolars were confirmed by CBCT and selected. The teeth were decoronated until a length of 16 ± 0.5mm. The teeth were prepared and obturated using gutta-percha and bioceramic sealer with a hydraulic condensation technique. Pre-instrumentation CBCT imaging of all teeth was carried out to obtain the initial volume of …

Mangosteen Peel Extract Vs Tetracycline Gel In Treatment Of Periodontal Abscess In Type-2 Diabetes – A Randomized Clinical Trial, Ksv Ramesh, Itha Joshna, Gautami S. Penmetsa, Gottumukkala Nvs Sruthima, Pasupuleti Mohan Kumar, Boddeda Anusha, Sathya Valli

Journal of Dentistry Indonesia

Herbal products are gaining popularity due to their diverse biological action and safety. Mangosteen peel extract has antibacterial and anti-inflammatory properties and can be used to treat periodontal diseases. Objective: To compare the efficacy of mangosteen peel extract and tetracycline gel as an adjunct to non-surgical management of periodontal abscess in type-II diabetes patients. Methods: This was a double blinded, randomized clinical trial included 20 Patients with Type-II diabetes. Both test and control groups received NSPT followed by adjunctive local application of mangosteen peel extract and tetracycline gel. Clinical parameters i.e., Probing depth (PPD), Clinical attachment level (CAL), …

Determination Of Demographic, Systemic, And Radiographic Characteristics Of Patients Applied To The Oral And Maxillofacial Radiology Clinic, Ayşe Taş, Selmi Yardimci

Journal of Dentistry Indonesia

Objective: Anamnesis, extraoral intraoral examination, radiographic examination, and other special examination methods are used to diagnose diseases in the oral and maxillofacial regions. The aim of this study was to establish the demographic, systemic, and radiographic characteristics of the patients by analyzing the records of patients who were treated at the Oral and Maxillofacial Radiology Clinic of the University Faculty of Dentistry. Methods: The anamnesis and diagnostic records of patients who were treated at the OMR clinic between 01.01.2013 and 31.12.2019 and the radiographic records of the patients referred to the X-ray department were retrospectively analyzed. The number of patients …

Reliability Of Three-Dimensional Micro-Computed Tomography Root Canal Analysis Using Drishti Software: A Pilot Study, Nurulaqmar Iwani Samsudin, Marlena Kamaruzaman, Afiq Azizi Jawami

Journal of Dentistry Indonesia

In recent years, micro-computed tomography (micro-CT) has become a promising tool for non-destructive imaging and the study of root canal morphology in endodontics. However, the reliability of such analyses heavily relies on the accuracy and consistency of the software used for image processing. Objective: This study aims to investigate the reliability of two different micro-CT voxel sizes using open-source three-dimensional (3D) software (Drishti v3.0) used to identify and quantify the Apical Foramen (AF) and Apical Constriction (AC) in mandibular premolars. Methods: Eight mandibular premolars were divided into two groups, with four samples in each group. Samples were scanned using a …

Current Update Of Clinical Therapeutic Strategies For Colon-Targeted Delivery Systems, Risa Widiani Batubara, Fadlina Chany Saputri, Raditya Iswandana

Pharmaceutical Sciences and Research

Oral colon-targeted drug delivery systems represent a significant advancement offering both systemic and local therapeutic effects for a range of intestinal diseases, including irritable bowel syndrome, inflammatory bowel disease, colonic bacterial infections, and colorectal cancer. These systems facilitate the delivery of both small molecules and macromolecular compounds such as peptides, proteins, antibodies, oligonucleotides, RNA, and probiotics. This review provides an up-to-date exploration of the critical factors crucial for the effective design and development of drug delivery systems targeting the colon. The chosen strategy takes into account various aspects of colon physiology that influences the profile of drug release, absorption, dissolution, …

Transdermal Delivery Of Ketoprofen For Osteoarthritis Treatment And Management: A Literature Review On Current Progression, Dwi Asih Ramadhani, Yahdiana Harahap, Erny Sagita, Kartika Citra Dewi Permata Sari, Rr. Kirana Andranilla, Jessica Trisina, Gabriella Frederika Punu, Delly Ramadon

Pharmaceutical Sciences and Research

Arthritis, a diverse spectrum of joint disorders, is characterized by chronic pain and inflammation. Osteoarthritis (OA), the most prevalent form, leads to disabling pain, functional limitations, and reduced mobility. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for managing OA pain, with ketoprofen recognized as one of the effective options. However, oral administration of ketoprofen may cause gastrointestinal irritation. Addressing this issue, Transdermal Drug Delivery Systems (TDDS) emerge as a promising alternative route of administration. TDDS facilitates delivery of various drugs through the skin without undergoing first-pass metabolism. Recent studies have centered on enhancing ketoprofen’s transdermal delivery, particularly focusing on different …

Antioxidant, Tyrosinase Inhibition Activity, And In Vitro Spf Evaluation Of Pepino Fruit Extract (Solanum Muricatum Aiton) In Different Solvent Types And Concentrations, Nining Sugihartini, Girly Risma Firsty, Wahyu Kumil Laila, Sri Mulyaningsih, Ichwan Ridwan Rais

Pharmaceutical Sciences and Research

Solvent is a key factor that affects the effectiveness of active compound extraction from plant materials (simplisia). This study aimed to determine the optimal type and concentration of solvent used in the extraction of pepino fruit based on the parameter of antioxidant and tyrosinase inhibition activity, as well as Sun Protection Factor (SPF) value. The extraction was carried out using the maceration method with ethanol or ethyl acetate as the solvent, each at concentrations of 50%, 70%, and 96%, respectively. The antioxidant activity of the extracts was evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. The inhibition of tyrosinase and …

Hubungan Rasio Neutrofil Limfosit Terhadap Komplikasi Kardiovaskular Pada Pasien Penyakit Ginjal Kronik Hemodialisis, Thariq Hikmatul Akmal, Agung Susanto, Ratih Tri Kusuma Dewi, Agus Jati Sunggoro

Jurnal Penyakit Dalam Indonesia

Introduction. The neutrophil-to-lymphocyte ratio (NLR) is a simple parameter to assess the inflammatory status, especially in chronic kidney disease (CKD) patients experiencing capillary damage due to increased glomerular capillary pressure. In a state of vascular endothelial inflammation, there is a higher tendency to form atherosclerotic plaques and calcification that can induce cardiovascular events such as heart failure, coronary heart disease, and stroke. This study aimed to determine the relationship between the NLR and cardiovascular complications in CKD patients undergoing hemodialysis.

Methods. An analytical observational study with cross-sectional approach was conducted among 119 CKD patients undergoing hemodialysis at Dr …

Evaluasi Pengukuran Kekakuan Limpa Dalam Memprediksi Perdarahan Varises Esofagus Berulang Pada Pasien Sirosis Hati, Andi Cahaya Tahir, Juferdy Kurniawan, Marcellus Simadibrata, Aulia Rizka, Hamzah Shatri, Cosmas Rinaldi A. Lesmana, Nadia Ayu Mulansari

Jurnal Penyakit Dalam Indonesia

Introduction. Esophageal variceal bleeding is one of the complications caused by an increase in pressure within the portal vein blood vessels. The gold standard examination for portal pressure is the hepatic venous pressure gradient (HVPG), but HVPG examination is invasive, involving transjugular catheterization of the hepatic vein. Currently, non-invasive methods for measuring portal hypertension are being developed to predict esophageal varices and esophageal variceal bleeding using spleen stiffness measurements. This study aimed to evaluate the accuracy of spleen stiffness measurement in predicting recurrent esophageal variceal bleeding in patients with liver cirrhosis.

Methods. This study used a retrospective cohort …

Hubungan Tingkat Stres, Kecemasan, Dan Depresi Dengan Konstipasi Fungsional Pada Mahasiswa Kedokteran, Khafifah Z, Wilson Wilson, Agustina Arundina Triharja Tejoyuwono

Jurnal Penyakit Dalam Indonesia

Introduction. Stress, anxiety, and depression are factors associated with functional constipation that affect students’ quality of life. Stress, anxiety, and depression are often experienced by first-year medical students, but studies assessing these three variables with functional constipation are still limited.

Methods. This study used a cross-sectional analytical design. Study was carried out in July 2023 involving 88 first-year medical students from the Tanjungpura University Medical Study Program. Analysis of relationship tests was carried out using Kendall’s Tau-B tests.

Results. Most students were in the normal category of stress, anxiety and depression levels, however 21 students were in …