Medicine and Health Sciences Commons^™

Program Penanganan Fakir Miskin Di Desa Mulyasari Kota Banjar Provinsi Jawa Barat, Aep Rusmana, Eri Susanto, Muhammad Rai Jemadila, Nabila Aulia Putri

Jurnal Ilmu Kesejahteraan Sosial

Poverty is a condition where a person cannot fulfill their basic needs to achieve a more dignified life. This research aims to explain the program for handling the poor in Mulyasari Village which is directed at three things, namely: 1) managing social problems, 2) mechanisms for meeting needs, and 3) providing opportunities for advancement for the poor. The method used in this research is a descriptive qualitative method with a phenomenological tradition. Determining the research sample used purposive sampling technique. There were 6 research informants consisting of Mulyasari Village officials, poor families who received social welfare services, and Community Social …

Keterlibatan Serikat Pekerja Dalam Perubahan Kebijakan Pengupahan Melalui Advokasii Sosial, Zeni Tri Lestari, Arif Wibowo

Jurnal Ilmu Kesejahteraan Sosial

This research is about the involvement of trade unions in changing wage policies through social advocacy from the social welfare perspective. The urgency of conducting this research is to reveal how KASBI's involvement as a worker's union encourages changes in wage policies to ensure better labor welfare through advocacy against the Job Creation Law and advocacy against Minister of Manpower Regulation Number 2 of 2022. This research uses a descriptive qualitative method. Data were collected from February to June 2023 through online and offline interviews involving three informants selected by the purposive sampling technique. The research results reveal that KASBI …

Pengembangan Sistem Informasi Desa Dalam Upaya Penanggulangan Kemiskinan Di Desa Rarang Selatan, Meita Annisa, Bambang Shergi Laksmono

Jurnal Ilmu Kesejahteraan Sosial

Indonesia continues to face challenges in poverty alleviation, with extreme poverty still prevalent in the country. Despite having a social protection system aimed at reducing poverty and cushioning the poor and vulnerable from crises, its implementation often encounters difficulties, particularly in obtaining valid and verified data sources. This study explores how the development of the Village Information System (SID) can contribute to poverty alleviation in Rarang Selatan Village, West Nusa Tenggara Province (NTB). When SID was introduced in 2016, Rarang Selatan was a newly established village classified as underdeveloped. By 2022, the village had progressed to the category of an …

Profilaksis Vs. Terapi Preemtif Penyakit Cytomegalovirus (Cmv) Pada Pasien Transplantasi Ginjal Risiko Tinggi: Suatu Laporan Kasus Berbasis Bukti, Ariani Intan Wardhani, Rahajeng N. Tunjungputri, Erpryta Nurdia Tetrasiwi, Maruhum Bonar Marbun

Jurnal Penyakit Dalam Indonesia

Kidney transplant recipients require the use of immunosuppressive agents to prevent multiple organ rejection. Administration of immunosuppressive agents triggers an increased risk of impaired immunity and microbial infections, one of which is cytomegalovirus (CMV). Prevention of cytomegalovirus infection can be given as a prophylaxis or preemptive therapy. However, the efficacy of choosing prophylaxis or preemptive therapy is still under debate, thus we conducted this study to identify current approach in preventing CMV disease in clinical practice. A literature search was carried out using the PubMed, Cochrane Library, Embase and Scopus databases with the keywords “high risk …

Perbedaan Serotonin Plasma Dan Kortisol Saliva Terhadap Gejala Depresi Pada Pasien Pasca Sindrom Koroner Akut, Irman Firmansyah, Hamzah Shatri, Rudi Putranto, Yanuar Ardani, Eka Ginanjar, Sukamto Koesnoe, Aulia Rizka, Harry Isbagio, Em Yunir

Jurnal Penyakit Dalam Indonesia

Introduction. Psychological disorders are closely associated with hormonal factors, including cortisol and serotonin. In patients with acute coronary syndrome (ACS), autonomic dysfunction and dysregulation of the hypothalamic-pituitaryadrenal (HPA) axis can occur, leading to an increase in cortisol levels that may worsen the prognosis of ACS patients. Therefore, it is important to understand the hormonal impact, namely cortisol and serotonin levels, on depressive symptoms, which will be examined in this study.

Methods. This was a cross-sectional study to determine the impact of cortisol and serotonin in the incidence of depression in post-treatment ACS patients at the ICCU RSUPN dr. …

Perlemakan Hati Non-Alkoholik Dan Risiko Fibrosis Hati Pada Pasien Hepatitis B Kronik, Andri Sanityoso Sulaiman, Irsan Hasan, Cosmas Rinaldi A. Lesmana, Juferdy Kurniawan, Chyntia Olivia Maurine Jasirwan, Saut Horas H. Nababan, Kemal Fariz Kalista, Gita Aprilicia, Rino Alvani Gani

Jurnal Penyakit Dalam Indonesia

Introduction. Prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing throughout the world due to sedentary lifestyle and dietary habit, including in patients with chronic hepatitis B (CHB). In several studies, advanced of liver disease were more likely observed among those CHB patients with NAFLD. NAFLD might increase the risk of liver disease progression in CHB patients, but prior investigations were still limited. This study aimed to determine the association between NAFLD and risk of liver fibrosis in CHB patients.

Methods. All patients with positive serum hepatitis B surface antigen in the Hepatobilier Data Registry, Cipto Mangunkusumo Hospital, …

Faktor-Faktor Yang Memengaruhi Kesintasan Pasien Yang Dilakukan Intervensi Koroner Perkutan Primer, Birry Karim

Jurnal Penyakit Dalam Indonesia

No abstract provided.

Perbedaan Kadar Insulin-Like Growth Factor-1 Dan Tumor Necrosis Factor-Α Serum Pada Berbagai Derajat Sarkopenia Pasien Lanjut Usia: Studi Potong Lintang, Auliangi Tamayo, Roza Mulyana, Rose Dinda Martini

Jurnal Penyakit Dalam Indonesia

Introduction. Sarcopenia is a phenomenon of progressive decline in muscle function that occurs due to the aging process. Insulin-like growth factor-1 (IGF-1) and tumor necrosis factor-α (TNF-α) have an important role in the occurrence of sarcopenia as a positive and negative regulator of muscle mass. Research shows differences in IGF-1 and TNF-α levels between sarcopenia and non-sarcopenia groups, but research on differences in severity of sarcopenia remains unclear. The purpose of this study was to determine the difference in levels of IGF-1 and TNF-α in various degrees of sarcopenia in elderly patients.

Methods. This was an analytical observational …

Sarkopenia Pada Lanjut Usia: Patogenesis, Diagnosis Dan Tata Laksana, Edwin Nugroho Njoto, I Gusti Putu Suka Aryana

Jurnal Penyakit Dalam Indonesia

‘Sarcopenia’ involves a progressive age-related loss of muscle mass and associated muscle weakness that renders frail elders susceptible to serious injury from sudden falls and fractures and losing their functional independence. This disease has a complex multifactorial pathogenesis, which involves not only age-related changes in neuromuscular function, muscle protein turnover, and hormone levels and sensitivity, but also a chronic pro-inflammatory state, oxidative stress, and behavioral factors – in particular, nutritional status and degree of physical activity. In the previous definition by the European Working Group on Sarcopenia in Older People (EWGSOP) in 2010, the diagnosis of sarcopenia requires the presence …

Manajemen Koinfeksi Malaria Berat Dengan Hiv Belum Mendapat Terapi Antiretrovirus Di Era Pandemi Covid-19: Sebuah Laporan Kasus, Paul Harijanto, Rosye Mawuntu, Novia Rusli, Randy Adiwinata, Agung Nugroho

Jurnal Penyakit Dalam Indonesia

Severe malaria is a serious infectious disease that required immediate diagnosis and prompt treatment. Severe malaria may result several organ failures which is similar with other infectious diseases like SARS-CoV-2, sepsis, dengue, and HIV infection. Most of those infection have similar symptoms such as fever, myalgia, and headache, therefore physician should have high suspicion regarding co-infection with other infectious agents. The overlapping symptoms of co-infections may become a challenge for physician in diagnosing and delivering prompt therapy. Failure to deliver prompt treatment may lead to fatal outcome such as in severe malaria case. Stigmatization of all patients with fever and …

Kesintasan Satu Tahun Pasien Yang Menjalani Intervensi Koroner Perkutan Primer Di Rumah Sakit Dr. Cipto Mangukusumo, Muhammad Afriadi Hamdan, Ika Prasetya Wijaya, Alvina Widhani, Muhammad Yamin

Jurnal Penyakit Dalam Indonesia

Introduction. Primary percutaneous coronary intervention (PPCI) is an angioplasty (with or without a stent) performed immediately on the infarct-related artery without prior administration of fibrinolytics. Although PPCI is the reperfusion therapy of choice in ST-segment Elevation Myocardial Infarction (STEMI) patients, survival in post-PPCI patients still varied and research on its determinant factors still showed inconsistent results. This study aimed to determine the predictors of oneyear survival in patients undergoing PPCI at Dr Cipto Mangunkusumo General Hospital.

Methods. This retrospective cohort study evaluated the medical records of patients who underwent PPCI at Dr. Cipto Mangunkusumo General Hospital from January …

Profil Pasien Ketoasidosis Diabetikum Di Rumah Sakit Rujukan Tersier Di Bali, Indonesia, Noviana Joenputri Nj, Ketut Suastika Ks, Wira Gotera Wg, Made Ratna Saraswati Mrs, I Made Pande Dwipayana Impd, I Made Siswadi Semadi Imss, Ida Bagus Aditya Nugraha Iban

Jurnal Penyakit Dalam Indonesia

Introduction. Diabetic ketoacidosis (DKA) is one of life-threatening acute complication of diabetes mellitus (DM) characterized by hyperglycemia, ketosis, and acidosis. The prevalence of DM is increasing, therefore the incidence of DKA is predicted to continue to increase. The aim of this study was to obtain the profile of DKA patients in RSUP Prof. Dr. IGNG. Ngoerah (RSPN), Denpasar, Bali as a tertiary refferal hospital of Bali and Nusa Tenggara region.

Methods. This study was a cohort retrospective study. All patients aged 18 years or older with a diagnosis of DKA during Januari 2022 to February 2023 at RSPN, …

Policy Implementation Analysis Of Spm Health Sector For Hypertension Sufferers In South Kalimantan Province, Indonesia In 2022, Anggi Asri Rusliana Dewi, Dumilah Ayuningtyas

Journal of Indonesian Health Policy and Administration

Hypertension is a major cardiovascular risk factor that causes disability throughout the world and among those who are not aware of their health condition, it is often referred to as the silent killer . The prevalence rate of hypertension in Indonesia is quite high. Based on Riskesdas (2018), South Kalimantan Province shows the highest prevalence of hypertension, but the percentage of hypertension sufferers who receive health services is still low. Banjarbaru City has the lowest percentage, namely 11.3% of the target of 100%. Health services for hypertension sufferers are included in the Minimum Service Standards (SPM) for the Health Sector …

Health Policy Reform Through Strengthening Indonesia's Health Resilience System, Wahyu Sulistiadi

Journal of Indonesian Health Policy and Administration

The National Health System in Indonesia is developing and being discussed more seriously after entering the COVID-19 pandemic. With a national health system and several existing tools, Indonesia needed more time to be ready to face the challenges of that time. Upstream health policies should be optimized to mobilize resources and increase the nation's efforts to build a national resilience system. This paper was built using selected policy documents up-to-date and reliable literature. By reviewing empirical evidence, the author believes and shows the role of strengthening health policies in building a robust national health resilience system. Indonesia has several policies …

The Effects Of Vaccination Against Covid-19 Incidence: Is The Current Age-Priorities Appropriate?, Dian Ip Nugrahari, Nurhanifah Hamdah

Journal of Indonesian Health Policy and Administration

Age is an independent risk factor for COVID-19. Thus, the government of Indonesia prioritizes the elderly and adults with significant comorbidities for COVID-19 vaccination. To discover whether this policy is still appropriate, we evaluated the effects of vaccination against the COVID-19 incidence and infection risk.It was a retrospective cohort study of the NAR COVID-19 and Dashboard KPCPEN COVID-19 of the Depok City Health Department. The tests used to analyze the data were the chi-square and logistic regression tests. We discovered that there was a 92.7% total reduction in the COVID-19 infection rate with vaccination. The infection risk for COVID-19 in …

Feminization Of Sri Lankan Doctors And Key Specialties: 2000 To 2020, Dileep De Silva, Pamila Adikari, Mihiri S. Rubasinghe, Udeni L. Seneviratne

Journal of Indonesian Health Policy and Administration

The study focused on the feminization of Sri Lankan generalist doctors in all major and selected minor specialties between 2000 and 2020. The study analyzed all relevant documents by exploring Sri Lanka's male-to-female doctor and specialist ratio over 20 years. This was determined by analyzing state medical faculty records from 1990 to 2020. For better clarity, the researchers analyzed the gender ratio changes in every five-year block from 1990 to 2020. Focus groups filled PGIM's gender data fields. Five-year medical students surged from 43% to 63% between 1990 and 2020. Linear trend analysis predicts 68% of female medical students by …

Sensitive Intervention Policy Recommendations To Reduce Stunting Rates Based On Spatial Analysis Of Sanitary Factors In Dki Jakarta Province 2021, Septiria Irawati, Ema Hermawati

Journal of Indonesian Health Policy and Administration

The purpose of this study was to describe the prevalence of stunting in children under five and the percentage of proper sanitation, as well as recommendations for priority areas for stunting control interventions in the Province of the Special Capital Region of Jakarta in 2021. This study used a descriptive approach to present an overview of the percentage of sanitation and prevalence of stunting in children under five by sub-district in 38 districts in DKI Jakarta. Data is displayed as a map to show distribution areas based on high, medium, and low categories. An overlay was made between the distribution …

Effect Of Calorie Restriction On The Expression Of Sirtuin1 As An Antiaging Biomarker, Raya Makarim Penantian, Radiana Dhewayani Antarianto, Novi Silvia Hardiany

Makara Journal of Science

Calorie restriction (CR) is the most effective method for delaying aging and preventing the onset of age-related diseases. Sirtuins constitute a family of nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylases. Their activity can be regulated by NAD⁺/NADH levels, which are influenced by nutrient intake, a variable acted upon by CR. This review elaborates on the link between CR and sirtuin1 (SIRT1). It retrieved articles from several sources, such as ClinicalKey, PubMed, and ScienceDirect. It discusses the up-to-date knowledge of how SIRT1 acts as a nutrient sensor and regulator of molecular mechanisms. These mechanisms include the control of the cell …

Fabrication And Characterization Of Nylon 6 Fiber Via Wet Spinning Method For Application As A Reinforcing Material For A Direct Dental Bridge, Dissa Kirana Wijaya, Nina Djustiana, Yanwar Faza, Arief Cahyanto, Andri Hardiansyah

Makara Journal of Science

Nylon is a biocompatible thermoplastic polymer that is well known for its excellent fracture resistance, making it suitable for fabricating fiber-reinforced composite (FRC)-based dental bridges. FRC is widely used in dentistry. This study aimed to investigate the structural and morphological characteristics of the nylon 6 fiber prepared using five different weights of nylon 6 dissolved in formic acid. The nylon 6 fiber was successfully fabricated via a simple wet spinning method using water as a coagulant. The fiber was then characterized using Fourier transform infrared (FTIR) spectroscopy, optical microscopy, and scanning electron microscopy. FTIR spectroscopy confirmed the presence of nylon …

In-Silico Approach For Predicting The Inhibitory Effect Of Home Remedies On Severe Acute Respiratory Syndrome Coronavirus-2, Shankar Thapa, Mahalakshmi Suresha Biradar, Janmajoy Banerjee, Dipanjan Karati

Makara Journal of Science

Severe Acute Respiratory Syndrome Coronavirus-2 is an infectious disease caused by coronavirus and spreads through infected droplets inhalation. For the past 3 years, COVID-19 has become a global threat. Vaccinations are currently available and have FDA approval. During the recent pandemic, people adopted a psychological belief that home remedies (turmeric, ginger, garlic, and coriander) can prevent COVID-19. This research aimed to predict the covid-19 inhibitory activities by home remedies through an in-silico approach. The 24 bioactive constituents of four home remedies plants were downloaded from PubChem and subjected to molecular docking with the three important proteins responsible for COVID-19 pathogenesis. …

Chicken Immune Responses To Vaccination By The Avian Influenza Subtype H5n1 Against Avian Influenza, Ramlah Ramlah, Sri Murtini, Retno Damayanti Soejoedono, Ketut Karuni Nyanakumari Natih, Siti Gusti Ningrum

Makara Journal of Science

Avian Influenza (AI) is one of the strategic animal diseases still considered a priority for control by the Indonesian government. This study aimed to examine the immune response of chickens to various types of H5N1 subtype AI vaccines in Indonesia and to determine the correlation of factors influencing the post-vaccination AI antibody response. Serum samples were tested using the hemagglutination inhibition (HI) test with the standard AI antigen subtype H5N1 strain A/Chicken/Barru/BBVM/41-13/2013 (Clade 2.1.3) and strain A/Chicken/Semarang/04141225-07/2014 (Clade 2.3.2). Antibody titer was calculated using the Geometric Mean Titer (GMT). The correlation analyses were performed to assess the correlation of antibody …

Synthesis Of Copper (Ii) Oxide Nanoparticles Using Vitis Vinifera L. Leaf Ex-Tract And Its Application As A Catalyst In Doebner Reaction, Felie Virgayani Kurniawan, Antonius Herry Cahyana, Rika Tri Yunarti

Makara Journal of Science

Plant extracts can be used to synthesize nanoparticle because it is efficient, economical, and friendly to the environment. Copper oxide nanoparticles (CuO NPs) were synthesized using an aqueous fraction of Vitis vinifera L leaf extract and Cu(NO₃)₂ solution as a precursor. This fraction contains secondary metabolites as a reduction agent and stabilizing agents to formed CuO NPs. CuO NPs can be used as a catalyst in a chemical reaction, one of which is the Doebner reaction, which is a simple and efficient reaction of aniline, aromatic aldehydes, and pyruvic acid under reflux conditions to produce derivatives quinoline-4-carboxylic …

Knowledge, Awareness, And Perceived Barriers Regarding Cervical Cancer Screening Among Bangladeshi Women Suffering From Cervical Cancer: A Cross-Sectional Study, Muhammed Mohibul Islam, Farhana Sultana, Md Hasan Shahriar Rahman, Nandita Islam Pia, Md. Al Hasibuzzaman, Arman Ahmed, Mohammed Shamim Hasan, Md Kayes Mahmud, Rabeya Akter, Md. Saqline Mostaq, Mohammad Nurul Amin

Makara Journal of Health Research

Background: This study aimed to evaluate the knowledge, awareness, and perceived barriers regarding cervical cancer screening among women in Bangladesh.

Methods: A hospital-based survey was conducted from January to April 2021 among 200 female participants. Statistical analysis of this study was performed by using Stata 13 (StataCorp LP, 4905 Lakeway Drive, College Station, TX 77845, USA), where Chi-square test was used for the determination of the correlation among different variables.

Results: Among the participants, 86.5% were rural residents, 96% were married, 87.5% were housewives, 47% were uneducated, and 93.5% lived on a husband’s income. Moreover, 84.5% hadn’t …

Solid Lipid Nanoparticles (Sln): Formulation And Fabrication, Gabriella F. Punu, Yahdiana Harahap, Qonita Kurnia Anjani, Pietradewi Hartrianti, Ryan F. Donnelly, Delly Ramadon

Pharmaceutical Sciences and Research

Solid lipid nanoparticles (SLN) have emerged as a novel drug delivery system and have been utilized for delivering various kinds of drugs since the 1990s. These particles may consist of multiple solid lipids, including glycerides, waxes, and fatty acids, and can be stabilized by a wide range of surfactants. SLN have garnered significant attention from researchers due to its innovative and versatile nature. Moreover, such delivery system has numerous advantages over traditional colloidal carriers, such as liposomes, polymeric nanoparticles, and emulsions. Several research groups have been developing SLN formulations and fabrication techniques based on their intended purpose, and this research …

Optimization Of Lubrication And Compression Process Parameters Of Vitamin C Film-Coated Caplets, Ernestine Arianditha Pranasti, Ratna Annisa Utami, Yuda Prasetya Nugraha

Pharmaceutical Sciences and Research

Tablet production is a very intricate process influenced by numerous process variables or parameters. This study aimed to identify the critical processing variables that affect Critical Quality Attributes (CQAs) of vitamin C film-coated caplets utilizing a statistical experimental design. A two-level complete factorial design with two central points was used to examine the process parameters that posed the greatest risk to CQAs. The process variables investigated included mesh size and duration for the lubrication process, as well as speed and main thickness for compression. Statistical results showed that mesh number, lubrication time, and their interaction significantly affect flow rate, Hausner …

A Qualitative Exploration Of Exclusive Breastfeeding Practices Among Karen Ethnicity Mothers In Northern Thailand Remote Rural Areas, Wanchalerm Ritthimon, Aksara Thongprachum, Jukkrit Wungrath

Kesmas

Low exclusive breastfeeding rates among the Karen ethnic group in Northern Thailand's remote rural areas underscore the need to understand knowledge, attitudes, and social support to develop targeted interventions. This qualitative study examined exclusive breastfeeding practices and the factors influencing breastfeeding behavior among 14 Karen Ethnicity Mothers (KEMs) in Northern Thailand. A structured interview was used to collect the data, a triangular method to determine the data's validity, and a content analysis method to examine the data revealed seven themes and 14 subthemes. This study identified three key factors for successful breastfeeding: self-motivation, social support, and effective problem management, which …

Healthy Lifestyle Behaviors And Sociodemographic Characteristics Among Medical Students In Indonesia During The New Normal Era: A Cross-Sectional Study, Sharren Shera Vionnetta, Tommy Nugroho Tanumihardja, Kevin Kristian

Kesmas

This study aimed to identify medical students’ healthy lifestyle behaviors during the new normal era and to determine its relationship with sociodemographic factors, bearing in mind that, as future physicians and health role models, medical students play an important role in adopting and promoting healthy lifestyle behaviors to reduce the risk of future health problems as well as optimize communities’ health status. This cross-sectional study was conducted at the School of Medicine and Health Sciences of Universitas Katolik Indonesia Atma Jaya, with 111 medical students selected through stratified random sampling. Data were collected using sociodemographic characteristics (sex, residence, year of …

Development Of A Medication Compliance Determinant Instrument For Low-Middle Literate Patients With Type 2 Diabetes Mellitus, Ivans Panduwiguna, Rani Sauriasari, Ratu Ayu Dewi Sartika, Woro Riyadina, Fransiskus Samuel Renaldi

Kesmas

Diabetes, a leading cause of 6.7 million deaths in 2021, poses a significant challenge despite existing interventions. Non-adherence to treatment remains a barrier to diabetes management. However, a comprehensive instrument to assess medication adherence determinants in diabetes patients’ population in Indonesia with low-medium literacy levels and following the sociocultural characteristics of Indonesian society has been lacking. This study aimed to develop and evaluate a valid and reliable instrument for measuring medication adherence in type 2 diabetes mellitus patients based on the Borg and Gall model. Through the input of an expert panel, a valid and reliable instrument was developed, which …

Effects Of Early Hospital-Based Palliative Care Consultation On Length Of Stay And Costs Of Care At Indonesian Tertiary Hospital, Rudi Putranto, Hamzah Shatri, Wulyo Rajabto, Sumariyono Sumariyono, Edward Faisal, Sihwastuti Sihwastuti

Kesmas

Despite the numerous benefits of palliative care for cancer patients, there have been few studies on palliative care services for terminal cancer patients, particularly near the end of life. This study aimed to evaluate whether there were differences in length of stay and cost of care associated with how early or late a patient received palliative care intervention. Another objective was to compare the length of stay and cost of care of those who received palliative care intervention and those who did not. This study used a cohort retrospective design at Hospital A, Jakarta, Indonesia, from January to December 2019. …

Risk Factors Of Worsening Of Systemic Lupus Erythematosus In Patients At Two Tertiary Hospitals In Jakarta, Giri Aji, Mondastri Korib Sudaryo, Ratna Djuwita, Sukamto Sukamto

Kesmas

Systemic Lupus Erythematosus (SLE) is a prototypical multiorgan autoimmune disease with a fluctuating and chronic disease course. As an emerging disease in this century, SLE will burden stakeholders and the country. This study was conducted to determine the prognostic factors for SLE worsening, especially in ambulatory patients. This ambispective study used logistic regression to view the risk factors for worsening SLE in patients. Anemia, age, body mass index, education level, employment status, marital status, hydroxychloroquine, and immunosuppressants were the independent variables in this study. This study concludes that anemia is statistically significant and, therefore, a risk factor for worsening SLE …