Medicine and Health Sciences Commons^™

Population Health Research: Early Description Of The Organizational Shift Toward Population Health Management And Defining A Vision For Leadership., Kristi L. Caldararo, David B. Nash

College of Population Health Faculty Papers

As health care delivery systems adapt to the changing marketplace, many struggle to define a clear strategy that will prove successful in managing the health of entire populations. The federal government continues to put increasing pressure on organizations to shift away from the traditional way of delivering episodic care and move toward managing populations as a whole-before, during, and after a patient presents in a health care facility. Private payers have begun to follow suit as risk-based payer contracts and bundled payment models become increasingly popular. For organizations to adequately influence the health outcomes of a population, they must be …

Trends In Unsolicited Dermatologic Opinions: A National Survey, Jordan Wang, Dorota Z. Korta, Christopher B. Zachary, Matthew S. Keller

Department of Dermatology and Cutaneous Biology Faculty Papers

In dermatology, a particularly common ethical dilemma can arise when the skin lesions of bystanders are inadvertently viewed in public settings. Dermatology is a unique field, where a person’s organ of interest is readily visible to others. When lesions are suspicious for skin disease, unsolicited medical opinions may or may not be given depending on several factors. This study examined the actions and attitudes of dermatologists with different levels of experience through the use of case scenarios with various settings and skin lesions. © 2017, Dermatology Online Journal. All rights reserved.

Detection And Molecular Status Of Isospora Sp. From The Domestic Pigeon (Columba Livia Domestica)., Ryuma Matsubara, Yasuhiro Fukuda, Fumi Murakoshi, Osamu Nomura, Toru Suzuki, Chika Tada, Yutaka Nakai

Department of Biochemistry and Molecular Biology Faculty Papers

The domestic pigeon, Columba livia domestica, is reared for meat production, as a pet, or for racing. Few reports have characterized the parasitic protists from the genus Isospora isolated from Columbiformes. We detected Isospora-like oocysts from C. livia reared for racing. The oocyst contained two sporocysts, and each sporocyst included four sporozoites. The sporulated oocysts (n=4) were spherical; their mean diameters were 25.6 (24.0-27.2)×24.7 (23.4-26.0) μm. Micropyles, polar granules, and oocyst residuum were absent. The mean length and width of the sporocysts (n=8) were 19.5 (18.5-20.5) and 11.2 (10.2-12.1) μm, respectively. Stieda and sub-Stieda bodies were observed. Single-oocyst PCR revealed …

An Unknown Reaction To Pembrolizumab: Giant Cell Arteritis., Ida Micaily, Md, Marc Chernoff, Do

Department of Medicine Faculty Papers

An 88 year old female with a past medical history of a hypertension, atrial fibrillation, and stage IV non-small cell lung cancer (NSCLC) presented to the emergency department with sudden onset left eye blindness and abdominal pain. She was noted to have worsening anemia and heme-occult positive stools, however abdominal imaging did not indicate any acute pathology. Given her baseline poor functional status, the patient was not a candidate for aggressive interventions. One week prior to presentation, the patient had received a first dose of pembrolizumab, 200 mg intravenous infusion, which was to be administered once every 3 weeks. Upon …

Acute Stroke Multimodal Imaging: Present And Potential Applications Toward Advancing Care., Ivan Matos Diaz, John W. Liang, L. Velickovic Ostojic, Aaron P. Tansy

Department of Neurology Faculty Papers

In the past few decades, the field of acute ischemic stroke (AIS) has experienced significant advances in clinical practice. A core driver of this success has been the utilization of acute stroke imaging with an increasing focus on advanced methods including multimodal imaging. Such imaging techniques not only provide a richer understanding of AIS in vivo, but also, in doing so, provide better informed clinical assessments in management and treatment toward achieving best outcomes. As a result, advanced stroke imaging methods are now a mainstay of routine AIS practice that reflect best practice delivery of care. Furthermore, these imaging methods …

Obstetricians' And Gynecologists' Knowledge, Education, And Practices Regarding Chronic Hepatitis B In Pregnancy., Bolin Niu, Dina Halegoua-De Marzio, Jonathan M. Fenkel, Steven K. Herrine

Division of Gastroenterology and Hepatology Faculty Papers

Background: In pregnant women with high viral loads, third-trimester initiation of antiviral agents can reduce the risk of vertical transmission. We aimed to assess obstetricians' and gynecologists' (OB-GYN) knowledge and clinical practice when treating pregnant women with chronic hepatitis B virus (HBV).

Methods: All program directors (PDs) from 250 US OB-GYN residency programs were invited to anonymously complete an 18-item questionnaire. Descriptive statistics were calculated and analyzed.

Results: A total of 323 participants responded, including both PDs (n=51, response rate 21%) and residents (n=272, response rate 11%). Responding PDs (62% university-based vs. 32% community-based) came from various practice types. All …

The Kinetic Mechanism Of Bacterial Ribosome Recycling., Yuanwei Chen, Akira Kaji, Hideko Kaji, Barry S. Cooperman

Department of Biochemistry and Molecular Biology Faculty Papers

Bacterial ribosome recycling requires breakdown of the post-termination complex (PoTC), comprising a messenger RNA (mRNA) and an uncharged transfer RNA (tRNA) cognate to the terminal mRNA codon bound to the 70S ribosome. The translation factors, elongation factor G and ribosome recycling factor, are known to be required for recycling, but there is controversy concerning whether these factors act primarily to effect the release of mRNA and tRNA from the ribosome, with the splitting of the ribosome into subunits being somewhat dispensable, or whether their main function is to catalyze the splitting reaction, which necessarily precedes mRNA and tRNA release. Here, …

Structural Basis For Selective Inhibition Of Cyclooxygenase-1 (Cox-1) By Diarylisoxazoles Mofezolac And 3-(5-Chlorofuran-2-Yl)-5-Methyl-4-Phenylisoxazole (P6)., Gino Cingolani, Andrea Panella, Maria Grazia Perrone, Paola Vitale, Giuseppe Di Mauro, Cosimo G G. Fortuna, Roger S. Armen, Savina Ferorelli, William L. Smith, Antonio Scilimati

Department of Biochemistry and Molecular Biology Faculty Papers

The diarylisoxazole molecular scaffold is found in several NSAIDs, especially those with high selectivity for COX-1. Here, we have determined the structural basis for COX-1 binding to two diarylisoxazoles: mofezolac, which is polar and ionizable, and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6) that has very low polarity. X-ray analysis of the crystal structures of COX-1 bound to mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole allowed the identification of specific binding determinants within the enzyme active site, relevant to generate structure/activity relationships for diarylisoxazole NSAIDs.

Decorin-Evoked Paternally Expressed Gene 3 (Peg3) Is An Upstream Regulator Of The Transcription Factor Eb (Tfeb) In Endothelial Cell Autophagy., Thomas Neill, Catherine Sharpe, Rick T. Owens, Renato V. Iozzo

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Macroautophagy is a fundamental and evolutionarily conserved catabolic process that eradicates damaged and aging macromolecules and organelles in eukaryotic cells. Decorin, an archetypical small leucine-rich proteoglycan, initiates a protracted autophagic program downstream of VEGF receptor 2 (VEGFR2) signaling that requires paternally expressed gene 3 (PEG3). We have discovered that PEG3 is an upstream transcriptional regulator of transcription factor EB (TFEB), a master transcription factor of lysosomal biogenesis, for decorin-evoked endothelial cell autophagy. We found a functional requirement of PEG3 for TFEB transcriptional induction and nuclear translocation in human umbilical vein endothelial and PAER2 cells. Mechanistically, inhibiting VEGFR2 or AMP-activated protein …

Sex Differences In Rt-Pa Utilization At Hospitals Treating Stroke: The National Inpatient Sample., Amelia K. Boehme, Brendan G. Carr, Scott Eric Kasner, Karen C Albright, Michael J. Kallan, Mitchell S V S.V. Elkind, Charles C. Branas, Michael T. Mullen

Department of Emergency Medicine Faculty Papers

BACKGROUND AND PURPOSE: Sex and race disparities in recombinant tissue plasminogen activator (rt-PA) use have been reported. We sought to explore sex and race differences in the utilization of rt-PA at primary stroke centers (PSCs) compared to non-PSCs across the US.

METHODS: Data from the National (Nationwide) Inpatient Sample (NIS) 2004-2010 was utilized to assess sex differences in treatment for ischemic stroke in PSCs compared to non-PSCs.

RESULTS: There were 304,152 hospitalizations with a primary diagnosis of ischemic stroke between 2004 and 2010 in the analysis: 75,160 (24.7%) patients were evaluated at a PSC. A little over half of the …

Cib1 Protects Against Mptp-Induced Neurotoxicity Through Inhibiting Ask1., Kyoung Wan Yoon, Hyun-Suk Yang, Young Mok Kim, Yeonsil Kim, Seongman Kang, Woong Sun, Ulhas P. Naik, Leslie V. Parise, Eui-Ju Choi

Department of Medicine Faculty Papers

Calcium and integrin binding protein 1 (CIB1) is a calcium-binding protein that was initially identified as a binding partner of platelet integrin αIIb. Although CIB1 has been shown to interact with multiple proteins, its biological function in the brain remains unclear. Here, we show that CIB1 negatively regulates degeneration of dopaminergic neurons in a mouse model of Parkinson's disease using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Genetic deficiency of the CIB1 gene enhances MPTP-induced neurotoxicity in dopaminergic neurons in CIB1(-/-) mice. Furthermore, RNAi-mediated depletion of CIB1 in primary dopaminergic neurons potentiated 1-methyl-4-phenyl pyrinidium (MPP(+))-induced neuronal death. CIB1 physically associated with apoptosis signal-regulating kinase 1 …

Rabies Screen Reveals Gpe Control Of Cocaine-Triggered Plasticity., Kevin T. Beier, Christina K. Kim, Paul Hoerbelt, Lin Wai Hung, Boris D. Heifets, Katherine E. Deloach, Timothy J. Mosca, Sophie Neuner, Karl Deisseroth, Liqun Luo, Robert C. Malenka

Department of Neuroscience Faculty Papers

Identification of neural circuit changes that contribute to behavioural plasticity has routinely been conducted on candidate circuits that were preselected on the basis of previous results. Here we present an unbiased method for identifying experience-triggered circuit-level changes in neuronal ensembles in mice. Using rabies virus monosynaptic tracing, we mapped cocaine-induced global changes in inputs onto neurons in the ventral tegmental area. Cocaine increased rabies-labelled inputs from the globus pallidus externus (GPe), a basal ganglia nucleus not previously known to participate in behavioural plasticity triggered by drugs of abuse. We demonstrated that cocaine increased GPe neuron activity, which accounted for the …

Different Effects Of Maternal Low-Isoflavone Soy Protein And Genistein Consumption On Hepatic Lipid Metabolism Of 21-Day-Old Male Rat Offspring., Anna Han, Sae Bom Won, Young Hye Kwon

Department of Cancer Biology Faculty Papers

Amino acid composition and isoflavone are alleged contributors to the beneficial effects of soy protein isolate (SPI) on lipid metabolism. Therefore, we investigated the contributing component(s) of SPI in a maternal diet to the regulation of lipid metabolism in offspring. We also determined serum parameters in dams to investigate specific maternal cues that might be responsible for this regulation. Female rats were fed either a casein (CAS), a low-isoflavone SPI, or a casein plus genistein (GEN, 250 mg/kg) diet for two weeks before mating, as well as during pregnancy and lactation. Male offspring (CAS, SPI and GEN groups) were studied …

Additional Sex Combs Interacts With Enhancer Of Zeste And Trithorax And Modulates Levels Of Trimethylation On Histone H3k4 And H3k27 During Transcription Of Hsp70., Taosui Li, Jacob W Hodgson, Svetlana Petruk, Alexander Mazo, Hugh W Brock

Department of Biochemistry and Molecular Biology Faculty Papers

BACKGROUND: Maintenance of cell fate determination requires the Polycomb group for repression; the trithorax group for gene activation; and the enhancer of trithorax and Polycomb (ETP) group for both repression and activation. Additional sex combs (Asx) is a genetically identified ETP for the Hox loci, but the molecular basis of its dual function is unclear.

RESULTS: We show that in vitro, Asx binds directly to the SET domains of the histone methyltransferases (HMT) enhancer of zeste [E(z)] (H3K27me3) and Trx (H3K4me3) through a bipartite interaction site separated by 846 amino acid residues. In Drosophila S2 cell nuclei, Asx interacts with …

Erenumab (Amg 334) In Episodic Migraine: Interim Analysis Of An Ongoing Open-Label Study., Messoud Ashina, David Dodick, Peter J. Goadsby, Uwe Reuter, Stephen Silberstein, Feng Zhang, Julia R. Gage, Sunfa Cheng, Daniel D. Mikol, Robert A. Lenz

Department of Neurology Faculty Papers

OBJECTIVE: To assess long-term safety and efficacy of anti-calcitonin gene-related peptide receptor erenumab in patients with episodic migraine (EM).

METHODS: Patients enrolled in a 12-week, double-blind, placebo-controlled clinical trial (NCT01952574) who continued in an open-label extension (OLE) study will receive erenumab 70 mg every 4 weeks for up to 5 years. This preplanned interim analysis, conducted after all participants had completed the 1-year open-label follow-up, evaluated changes in monthly migraine days (MMD), achievement of ≥50%, ≥75%, and 100% reductions, Headache Impact Test (HIT-6) score, Migraine-Specific Quality of Life (MSQ), Migraine Disability Assessment (MIDAS), and safety. Data reported as observed without …

Incontinentia Pigmenti In A Child With Suspected Retinoblastoma., Stephanie J. Weiss, Archana Srinivasan, Michael A. Klufas, Carol L. Shields

Wills Eye Hospital Papers

BACKGROUND: Incontinentia pigmenti is a rare X-linked dominant syndrome caused by mutation in the NEMO/IKKgamma gene, and characterized by a spectrum of cutaneous, ocular, neurologic and dental abnormalities. In the eye, findings include retinal vascular non-perfusion, occasionally with traction retinal detachment, retinal fibrosis, and retinal pigment epithelium defects. These findings can resemble retinoblastoma, especially when vitreoretinal fibrosis produces leukocoria.

CASE REPORT: A 2-month-old girl born full-term presented with leukocoria, suspicious for retinoblastoma. She was found to have an ischemic retrolental fibrovascular retinal detachment. In addition, there was linear cutaneous hyperpigmentation, diagnostic of incontinentia pigmenti.

CONCLUSIONS: Retinoblastoma can be a challenge …

The Heat-Stable Enterotoxin Receptor, Guanylyl Cyclase C, As A Pharmacological Target In Colorectal Cancer Immunotherapy: A Bench-To-Bedside Current Report., Trevor R. Baybutt, Allison A. Aka, Adam E. Snook

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Cancer immunotherapy is becoming a routine treatment modality in the oncology clinic, in spite of the fact that it is a relatively nascent field. The challenge in developing effective immunotherapeutics is the identification of target molecules that promote anti-tumor efficacy across the patient population while sparing healthy tissue from damaging autoimmunity. The intestinally restricted receptor guanylyl cyclase C (GUCY2C) is a target that has been investigated for the treatment of colorectal cancer and numerous animal, and clinical studies have demonstrated both efficacy and safety. Here, we describe the current state of GUCY2C-directed cancer immunotherapy and the future directions of this …

Gucy2c Signaling Opposes The Acute Radiation-Induced Gi Syndrome., Peng Li, Evan Wuthrick, Jeff A. Rappaport, Crystal Kraft, Jieru E. Lin, Glen Marszalowicz, Adam E. Snook, Tingting Zhan, Terry M. Hyslop, Scott A. Waldman

Department of Pharmacology and Experimental Therapeutics Faculty Papers

High doses of ionizing radiation induce acute damage to epithelial cells of the gastrointestinal (GI) tract, mediating toxicities restricting the therapeutic efficacy of radiation in cancer and morbidity and mortality in nuclear disasters. No approved prophylaxis or therapy exists for these toxicities, in part reflecting an incomplete understanding of mechanisms contributing to the acute radiation-induced GI syndrome (RIGS). Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. Here, we reveal a role for the GUCY2C paracrine axis in compensatory mechanisms opposing RIGS. …

Posttranscriptional Regulation Of Parg Mrna By Hur Facilitates Dna Repair And Resistance To Parp Inhibitors, Saswati N. Chand, Mahsa Zarei, M. J. Schiewer, Akshay R. Sanan, Carmella Romeo, Shruti Lal, Joseph A. Cozzitorto, Avinoam Nevler, Laura Scolaro, Eric R. Londin, Wei Jiang, Nicole Meisner-Kober, Michael J. Pishvaian, Karen E. Knudsen, Charles Yeo, John M Pascal, Jordan M. Winter, Jonathan R. Brody

Department of Surgery Faculty Papers

The majority of pancreatic ductal adenocarcinomas (PDAC) rely on the mRNA stability factor HuR (ELAV-L1) to drive cancer growth and progression. Here, we show that CRISPR-Cas9–mediated silencing of the HuR locus increases the relative sensitivity of PDAC cells to PARP inhibitors (PARPi). PDAC cells treated with PARPi stimulated translocation of HuR from the nucleus to the cytoplasm, specifically promoting stabilization of a new target, poly (ADP-ribose) glycohydrolase (PARG) mRNA, by binding a unique sequence embedded in its 3⁰ untranslated region. HuR-dependent upregulation of PARG expression facilitated DNA repair via hydrolysis of polyADP-ribose on related repair proteins. Accordingly, strategies to …

Accuracy Of Emergency Medical Services Dispatcher And Crew Diagnosis Of Stroke In Clinical Practice., Judy Jia, Roger Band, Michael E. Abboud, William Pajerowski, Michelle Guo, Guy David, C. Crawford Mechem, Steven R Messé, Brendan G. Carr, Michael T Mullen

Department of Emergency Medicine Faculty Papers

BACKGROUND: Accurate recognition of stroke symptoms by Emergency Medical Services (EMS) is necessary for timely care of acute stroke patients. We assessed the accuracy of stroke diagnosis by EMS in clinical practice in a major US city.

METHODS AND RESULTS: Philadelphia Fire Department data were merged with data from a single comprehensive stroke center to identify patients diagnosed with stroke or TIA from 9/2009 to 10/2012. Sensitivity and positive predictive value (PPV) were calculated. Multivariable logistic regression identified variables associated with correct EMS diagnosis. There were 709 total cases, with 400 having a discharge diagnosis of stroke or TIA. EMS …

St-Producing E. Coli Oppose Carcinogen-Induced Colorectal Tumorigenesis In Mice., Peng Li, Jieru E. Lin, Adam E. Snook, Scott A. Waldman

Department of Pharmacology and Experimental Therapeutics Faculty Papers

There is a geographic inequality in the incidence of colorectal cancer, lowest in developing countries, and greatest in developed countries. This disparity suggests an environmental contribution to cancer resistance in endemic populations. Enterotoxigenic bacteria associated with diarrheal disease are prevalent in developing countries, including enterotoxigenic E. coli (ETEC) producing heat-stable enterotoxins (STs). STs are peptides that are structurally homologous to paracrine hormones that regulate the intestinal guanylyl cyclase C (GUCY2C) receptor. Beyond secretion, GUCY2C is a tumor suppressor universally silenced by loss of expression of its paracrine hormone during carcinogenesis. Thus, the geographic imbalance in colorectal cancer, in part, may …

Patient-Reported Outcome Assessment Of Inflammatory Arthritis Patient Experience With Intravenously Administered Biologic Therapy, Norman B. Gaylis, Joanne Sagliani, Shawn Black, Kezhen L. Tang, Raphael J. Dehoratius, Wesley A. Kafka, Dennis Parenti

Department of Medicine Faculty Papers

Objective: To evaluate patient perspectives regarding utilization of intravenous (IV) therapy for inflammatory arthritis (IA). Methods: This was a single-center, non-interventional, patient questionnaire-based study of adult IA patients currently receiving IV biologics. At a single visit, patients completed the questionnaire comprising 30 questions centered on their experience receiving an intravenously administered therapy to treat their IA. The questionnaire included questions on patient demographics, disease characteristics, and previous biologic treatment for IA (subcutaneous [SC] and IV). Patients rated their level of agreement with statements regarding satisfaction with current IV biologic therapy and potential advantages and disadvantages of IV biologic therapy using …

It Takes A Village, Valerie Smith (Interior Design), Allison Mccabe (Interior Design), Kelly Mcmullen (Interior Design), Evatt Holmström (Industrial Design), Coral Pistilli (Occupational Therapy)

Nexus Maximus

Through collaboration and teamwork, we tried to fulfill the needs of refugees coming into the country. We created a temporary society (urban plan) through the use of IKEA shelters in order to better the everyday lives of refugees who are in limbo waiting for approval in the country they landed. We hope the plan will spark a sense of community, contribution, and improve the mental health of the society residing there.

Nexus Maximus IV

The Challenge: Innovation for Refugees and Displaced Populations

One of the great challenges of our time is how to help refugees and displaced populations, and how …

Solar Stove, Julia Strange (Interior Design), Alaina Mcihenney (Physicians Assistant), Zachary Quain (Industrial Design), Adam Beauchner (Industrial Design), Irene Ghattas (Occupational Therapy)

Nexus Maximus

PEOPLE'S CHOICE AWARD WINNER!

We designed a solar powered hot plate that also functions as a light source. This allows refugees to cook food without burning wood or using toxic fuels and provides a portable light source.

Nexus Maximus IV

The Challenge: Innovation for Refugees and Displaced Populations

One of the great challenges of our time is how to help refugees and displaced populations, and how to prevent the causes in the first place. Every minute, 24 people around the world are forced to flee their homes. That’s 34,000 people a day who leave everything behind in the hope of …

Nah-Atlas, Samantha Schwartz (Interior Design), David Kahn (Industrial Design), Alana Thirsk (Industrial Design), Erick Iacono (Occupational Therapy)

Nexus Maximus

Current products that attempt to help crisis victims fail to address the most important problem at hand. Citizens feel like there is nothing they can do for people in other countries.

NAHAtlas strengthens the connection between the needs of refugees and the abilities of volunteers during crisis by providing a website that easily answers the main question people are asking.

Nexus Maximus IV

The Challenge: Innovation for Refugees and Displaced Populations

One of the great challenges of our time is how to help refugees and displaced populations, and how to prevent the causes in the first place. Every minute, 24 …

The Trade Exchange, Emily Monath (Industrial Design), Caroline Whittemore (Occupational Therapy), Wa’Ed Ibrahim (International Design Business Management), Michael Taffe (Finance), Bridget Sax (Interior Design)

Nexus Maximus

The Trade Exchange program changes the meaning of "refugee" from burden to asset. This job placement organization reduces depression and other mental health factors by capitalizing on refugees skills by placing them in countries with labor shortages.

Nexus Maximus IV

The Challenge: Innovation for Refugees and Displaced Populations

One of the great challenges of our time is how to help refugees and displaced populations, and how to prevent the causes in the first place. Every minute, 24 people around the world are forced to flee their homes. That’s 34,000 people a day who leave everything behind in the hope of …

Language Learning Application, Sarah Plonski (Landscape Architecture), Mohit Jain (Construction Management), Amar Chinni (Pre-Med), Venla Pirhonen, Victoria Silva (Advertising), Victoria Martinez (Marketing Engineering)

Nexus Maximus

An application that facilitates immersive language learning by connecting refugees to one another as language learning partners and to native-speaking tutors.

Our group worked to overcome language barriers of our own to complete this project. This work represents a major success in terms of collaborating across disciplines as well as cultures and languages.

Nexus Maximus IV

The Challenge: Innovation for Refugees and Displaced Populations

One of the great challenges of our time is how to help refugees and displaced populations, and how to prevent the causes in the first place. Every minute, 24 people around the world are forced to …

Ready Bag, Erica Stewart (Interior Design), Anna Petronio (Interior Design), Chelsey Glidden (Interior Design), William Guo (Business), Anna Slomowitz (Occupational Therapy)

Nexus Maximus

The Ready Bag is for people in the United States who have been displaced due to natural disasters. The bags contain all of the necessary products that people need for survival and disaster relief and it comes in one convenient bag. There are four options for different regions in the US that target specific natural disasters and provide people with a sense of security and preparedness.

Nexus Maximus IV

The Challenge: Innovation for Refugees and Displaced Populations

One of the great challenges of our time is how to help refugees and displaced populations, and how to prevent the causes in …

Refyougee, Joshua Ferguson (Industrial Design), Valmar Wilson, Nicholas Austin, Kaitlin Johnson (Interior Design), Alvari Poikola, Ignacio, Sebastian Eduardo Guajardo

Nexus Maximus

We created a temporary replica of a refugee camp, with the intent of creating empathy for refugees among the citizens of western countries.

Nexus Maximus IV

The Challenge: Innovation for Refugees and Displaced Populations

One of the great challenges of our time is how to help refugees and displaced populations, and how to prevent the causes in the first place. Every minute, 24 people around the world are forced to flee their homes. That’s 34,000 people a day who leave everything behind in the hope of finding safety and a better tomorrow. The impact of war, political, racial and religious …

S.A.V.E.-Safety And Vitals Emitter, Brandon Pun (Architecture), Fred Ramirez (Architecture)

Nexus Maximus

A series of devices created to assist in the location of those who have been affected by natural disasters. The devices utilize ultrasonic and infared signals to create a proximity and heat signature for those affected.

Nexus Maximus IV

The Challenge: Innovation for Refugees and Displaced Populations

One of the great challenges of our time is how to help refugees and displaced populations, and how to prevent the causes in the first place. Every minute, 24 people around the world are forced to flee their homes. That’s 34,000 people a day who leave everything behind in the hope of finding …