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Thomas Jefferson University

2002

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Articles 1 - 29 of 29

Full-Text Articles in Medicine and Health Sciences

Innovation In Occupational Therapy Practice: Evidence In Working With Families Caring For Persons With Dementia, Laura N. Gitlin Dec 2002

Innovation In Occupational Therapy Practice: Evidence In Working With Families Caring For Persons With Dementia, Laura N. Gitlin

Center for Applied Research on Aging and Health Research Papers

No abstract provided.


The Effectiveness Of Heart Failure Disease Management: Initial Findings From A Comprehensive Program, Janice L. Clarke, David B. Nash Dec 2002

The Effectiveness Of Heart Failure Disease Management: Initial Findings From A Comprehensive Program, Janice L. Clarke, David B. Nash

College of Population Health Faculty Papers

A prevalent, chronic condition among members of the mushrooming elderly population in the United States, heart failure (HF) is a logical focus for population-based disease management. Evidence supporting the premise that multidisciplinary interventions can significantly improve clinical outcomes while decreasing the cost of medical care for people with HF is steadily mounting. A growing number of controlled and observational studies focus on the effects of HF disease management on re-admission rates, length of stay, and improvement in appropriate diagnostic testing and prescribing. This paper describes a large-scale, comprehensive HF program and reports on clinical quality, utilization, and financial outcomes observed …


Predicting High Utilization Of Emergency Department Services Among Patients With A Diagnosis Of Psychosis In A Medicaid Managed Care Organization, Tammy K. Girts, Albert G. Crawford, Neil I. Goldfarb, Mark Bachleda, Amy Grogg Dec 2002

Predicting High Utilization Of Emergency Department Services Among Patients With A Diagnosis Of Psychosis In A Medicaid Managed Care Organization, Tammy K. Girts, Albert G. Crawford, Neil I. Goldfarb, Mark Bachleda, Amy Grogg

College of Population Health Faculty Papers

Studies have demonstrated increased utilization of medical services for patients with behavioral health diagnoses. Medicaid managed care organizations (MMCOs) that operate under behavioral health carve-outs face the challenge of effectively targeting disease management initiatives in the absence of information on behavioral diagnoses. This study sought to develop a predictive model of emergency department (ED) utilization for patients where a diagnosis of psychosis could be identified from a claim associated with a medical service provider visit. A retrospective cohort analysis was performed using medical and pharmacy claims from an MMCO in Philadelphia, Pennsylvania, to identify patients known to have a diagnosis …


Jefferson Alumni Bulletin – Volume 52, Number 1, December 2002 Dec 2002

Jefferson Alumni Bulletin – Volume 52, Number 1, December 2002

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 52, Number 1, December 2002 Dean's Column by Dean Thomas J. Nasca ’75, page 4 New Chairman of Medicine Art Feldman, page 6 Rao, Buchheit, Siegman, Wender Are Appointed Chairs, page 9 Emergency Medicine Is Made a Department, page 11 Hospital Is Named as the Best in Philadelphia, page 11 Technology Transfer in the 21st Century, page 12 In Kenya, Jeff Students Reach the Underserved, page 14 African Americans' Satisfaction with Medical Careers, page 15 Ana Maria Lopez '88: Reaching Out via Telemedicine, page 22 New Consolidation Rates for Student Borrowers, page 23 Monica Morrow …


Comparisons Of American, Israeli, Italian And Mexican Physicians And Nurses On The Total And Factor Scores Of The Jefferson Scale Of Attitudes Toward Physician-Nurse Collaborative Relationships, Mohammadreza Hojat, Joseph S. Gonnella, Thomas J. Nasca, Sylvia K. Fields, Americo Cicchetti, Alessandra Lo Scalzo, Francesco Taroni, Anna Maria Vincenza Amicosante, Manuela Macinati, Massimo Tangucci, Carlo Liva, Gualtiero Ricciardi, Schmuel Eidelman, Hanna Admi, Hana Geva, Tanya Mashiach, Gideon Alroy, Adelina Alcorta-Gonzalez, David Ibarra, Antonio Torres-Ruiz Nov 2002

Comparisons Of American, Israeli, Italian And Mexican Physicians And Nurses On The Total And Factor Scores Of The Jefferson Scale Of Attitudes Toward Physician-Nurse Collaborative Relationships, Mohammadreza Hojat, Joseph S. Gonnella, Thomas J. Nasca, Sylvia K. Fields, Americo Cicchetti, Alessandra Lo Scalzo, Francesco Taroni, Anna Maria Vincenza Amicosante, Manuela Macinati, Massimo Tangucci, Carlo Liva, Gualtiero Ricciardi, Schmuel Eidelman, Hanna Admi, Hana Geva, Tanya Mashiach, Gideon Alroy, Adelina Alcorta-Gonzalez, David Ibarra, Antonio Torres-Ruiz

CRMEHC Faculty Papers

This cross-cultural study was designed to compare the attitudes of physicians and nurses toward physician–nurse collaboration in the United States, Israel, Italy and Mexico. Total participants were 2522 physicians and nurses who completed the Jefferson Scale of Attitudes Toward Physician–Nurse Collaboration (15 Likert-type items, (Hojat et al., Evaluation and the Health Professions 22 (1999a) 208; Nursing Research 50 (2001) 123). They were compared on the total scores and four factors of the Jefferson Scale (shared education and team work, caring as opposed to curing, nurses, autonomy, physicians’ dominance). Results showed inter- and intra-cultural similarities and differences among the study groups …


The Review - Fall 2002 Oct 2002

The Review - Fall 2002

Jefferson Review

In This Issue

  • 3 - Message From the Dean
  • 4 - Drs. Erdmann and Cooter Take the Lead
  • 5 - Physical Therapy Class of 1992 Together Again
  • 6 - Mary G. Schaal, New Nursing Department Chair
  • 7 - Diagnostic Imaging Students Discover Presentation is Important
  • 8 - Special Occasions Make Special News
  • 9 - JAVA Keeps Admissions Brewing
  • 10 - Your Alma Mater Needs Your Support
  • 10 - Changing Spaces – Campus Housing Gets a Face Lift
  • 11 - Federal Stafford Loan and Interest Rates At An All Time Low
  • 11 - Barbara Schock Retires
  • 12 - Alumni and Almost …


Nurses Alumni Association Bulletin, Fall 2002, Paula Levine, Elizabeth K. Prisnock, Marian E. Smith, Sally H. Wagner, John J. Wagner Oct 2002

Nurses Alumni Association Bulletin, Fall 2002, Paula Levine, Elizabeth K. Prisnock, Marian E. Smith, Sally H. Wagner, John J. Wagner

Nursing Alumni Bulletins

2002 - 2003 Meeting Date Calendar

2003 Annual Luncheon & Meeting Notice

Officers and Committee Chairs

Bulletin Publication Committee

The President's Message

Treasurer's Report

Resume of Minutes

Office News

Committee Reports

  • Relief Trust Fund
  • Satellite - Harrisburg Satellite Area
  • Scholarship
  • Social
  • Nominating
  • By-Laws
  • Bulletin
  • Development

Annual Giving Contributions

News About Graduates

Janet C. Hindson Award

Celebrating 110 Years Nursing Excellence at TJU

Memories

A Nurse 2002

A Parish - What's That

50th Anniversary Class

Class of 1952 Trolley Tour

Happy Birthday to be 80 or more

In Memoriam, Names of Deceased Graduates

Center page

Class News

Scholarship Fund Application

Certification …


The Effect Of An Interdisciplinary Community Health Project On Student Attitudes Toward Community Health, People Who Are Indigent And Homeless, And Team Leadership Skill Development, Molly A. Rose, Kevin J. Lyons, Kathleen Swenson Miller, Diane Cornman-Levy Sep 2002

The Effect Of An Interdisciplinary Community Health Project On Student Attitudes Toward Community Health, People Who Are Indigent And Homeless, And Team Leadership Skill Development, Molly A. Rose, Kevin J. Lyons, Kathleen Swenson Miller, Diane Cornman-Levy

College of Nursing Faculty Papers & Presentations

This study examined whether students’ attitudes about community health practice, attitudes toward people who are indigent and homeless, and perceived leadership skills changed after participation in a planned interdisciplinary community health experience with an urban homeless or formerly homeless population. Data were collected from medicine, nursing, occupational therapy, physical therapy, and social work students who participated in the community health experiences and from students in these disciplines who did not participate in this curriculum. The interdisciplinary community health curriculum and practicum experiences, based on the Community Health Empowerment Model (CHEM), were designed and implemented by a coalition of community and …


Patient Attitudes Toward Using Computers To Improve Health Services Delivery, Chris N. Sciamanna, Joseph A. Diaz, Puja Myne Sep 2002

Patient Attitudes Toward Using Computers To Improve Health Services Delivery, Chris N. Sciamanna, Joseph A. Diaz, Puja Myne

College of Population Health Faculty Papers

BACKGROUND:The aim of this study was to examine the acceptability of point of care computerized prompts to improve health services delivery among a sample of primary care patients.

METHODS:Primary data collection. Cross-sectional survey. Patients were surveyed after their visit with a primary care provider. Data were obtained from patients of ten community-based primary care practices in the spring of 2001.

RESULTS:Almost all patients reported that they would support using a computer before each visit to prompt their doctor to: "do health screening tests" (92%), "counsel about health behaviors (like diet and exercise)" (92%) and "change treatments for health conditions" (86%). …


Physician Empathy: Definition, Components, Measurement, And Relationship To Gender And Specialty, Mohammadreza Hojat, Joseph S. Gonnella, Thomas J. Nasca, Salvatore Mangione Md, Michael Vergare, Michael Magee Sep 2002

Physician Empathy: Definition, Components, Measurement, And Relationship To Gender And Specialty, Mohammadreza Hojat, Joseph S. Gonnella, Thomas J. Nasca, Salvatore Mangione Md, Michael Vergare, Michael Magee

CRMEHC Faculty Papers

OBJECTIVE: There is a dearth of empirical research on physician empathy despite its mediating role in patient-physician relationships and clinical outcomes. This study was designed to investigate the components of physician empathy, its measurement properties, and group differences in empathy scores.

METHOD: A revised version of the Jefferson Scale of Physician Empathy (with 20 Likert-type items) was mailed to 1,007 physicians affiliated with the Jefferson Health System in the greater Philadelphia region; 704 (70%) responded. Construct validity, reliability of the empathy scale, and the differences on mean empathy scores by physicians’ gender and specialty were examined.

RESULTS: Three meaningful factors …


Economic And Health Outcomes Of Capsule Endoscopy: Opportunities For Improved Management Of The Diagnostic Process For Obscure Gastrointestinal Bleeding, Neil I. Goldfarb, Amy Phillips, Mitchell Conn, Blair S. Lewis, David B. Nash Sep 2002

Economic And Health Outcomes Of Capsule Endoscopy: Opportunities For Improved Management Of The Diagnostic Process For Obscure Gastrointestinal Bleeding, Neil I. Goldfarb, Amy Phillips, Mitchell Conn, Blair S. Lewis, David B. Nash

College of Population Health Faculty Papers

The estimated annual incidence of gastrointestinal bleeding in the United States is approximately 100 episodes per 100,000 persons, resulting in 300,000 hospitalizations annually. Diagnostic tools such as radiologic studies and endoscopic examination often fail to identify a source of bleeding, resulting in a cycle of repetitive testing over months or even years. Costs associated with the diagnostic process, and with interim treatment for anemia and other symptoms, can be significant. The diagnostic process also takes a toll on the patient, in terms of worry, pain, and discomfort. Capsule endoscopy, a technology that received FDA clearance in August, 2001, consists of …


Strong Partnerships Make Good Partners: Insights About Physician-Hospital Relationships From A Study Of Physician Executives, Marc A. Bard, Michael L. Buehler, Andrew L. Epstein, David B. Nash, John P. O'Connor Sep 2002

Strong Partnerships Make Good Partners: Insights About Physician-Hospital Relationships From A Study Of Physician Executives, Marc A. Bard, Michael L. Buehler, Andrew L. Epstein, David B. Nash, John P. O'Connor

College of Population Health Faculty Papers

While physicians are likely to respond favorably in concept to hospital-based disease management and other clinical programs, they are less likely to accept their structural and functional characteristics. Because of their role at the hospital-physician interface, hospital physician executives are often tasked with implementing such programs. Given the challenges involved, a deeper understanding of the role of these executives in building the hospital-physician relationship will therefore be an important contribution. To this end, we surveyed senior physician executives at hospitals and health systems (n = 326), to assess their view of the hospital-physician relationship at their institutions, focusing especially on …


Jefferson Alumni Bulletin – Volume 51, Number 4, September 2002 Sep 2002

Jefferson Alumni Bulletin – Volume 51, Number 4, September 2002

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 51, Number 4, September 2002 Dean's Message by Dean Thomas J. Nasca ’75, page 4 Achievement Award Winner Charles Francis ’65, page 6 Jim Bagian ’77 Receives an Honorary Doctorate, page 7 Reunions and Annual Giving, page 12 Class notes attached as supplemental file.


High-Resolution Physical Map For Chromosome 16q12.1-Q13, The Blau Syndrome Locus., Xiaoju Wang, Helena Kuivaniemi, Gina Bonavita, Charlene J Williams, Gerard Tromp Aug 2002

High-Resolution Physical Map For Chromosome 16q12.1-Q13, The Blau Syndrome Locus., Xiaoju Wang, Helena Kuivaniemi, Gina Bonavita, Charlene J Williams, Gerard Tromp

Department of Medicine Faculty Papers

BACKGROUND: The Blau syndrome (MIM 186580), an autosomal dominant granulomatous disease, was previously mapped to chromosome 16p12-q21. However, inconsistent physical maps of the region and consequently an unknown order of microsatellite markers, hampered us from further refining the genetic locus for the Blau syndrome. To address this problem, we constructed our own high-resolution physical map for the Blau susceptibility region. RESULTS: We generated a high-resolution physical map that provides more than 90% coverage of a refined Blau susceptibility region. The map consists of four contigs of sequence tagged site-based bacterial artificial chromosomes with a total of 124 bacterial artificial chromosomes, …


Jefferson Medical College Annual Report, 2002, Thomas J. Nasca Jul 2002

Jefferson Medical College Annual Report, 2002, Thomas J. Nasca

Jefferson Medical College Administrative Documents and Reports

No abstract provided.


Building Jefferson's Future, Douglas J. Macmaster Jr., Paul C. Brucker Jul 2002

Building Jefferson's Future, Douglas J. Macmaster Jr., Paul C. Brucker

Thomas Jefferson University Administrative Documents and Reports

2002 Annual report of Thomas Jefferson University.


Use Of An Anaerobic Chamber Environment For The Assay Of Endogenous Cellular Protein-Tyrosine Phosphatase Activities., Li Zhu, Barry Goldstein Jun 2002

Use Of An Anaerobic Chamber Environment For The Assay Of Endogenous Cellular Protein-Tyrosine Phosphatase Activities., Li Zhu, Barry Goldstein

Department of Medicine Faculty Papers

Protein-tyrosine phosphatases (PTPases) have a catalytic cysteine residue whose reduced state is integral to the reaction mechanism. Since exposure to air can artifactually oxidize this highly reactive thiol, PTPase assays have typically used potent reducing agents to reactivate the enzymes present; however, this approach does not allow for the measurement of the endogenous PTPase activity directly isolated from the in vivo cellular environment. Here we provide a method for using an anaerobic chamber to preserve the activity of the total PTPase complement in a tissue lysate or of an immunoprecipitated PTPase homolog to characterize their endogenous activation state. Comparison with …


Jefferson Alumni Bulletin - Volume 51, Number 3, June 2002 Jun 2002

Jefferson Alumni Bulletin - Volume 51, Number 3, June 2002

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 51, Number 3, June 2002 New Appointments; Page 4 Gift of Health: Herbert Kean Endows Chair in Otolaryngology; Page 6 Investigations: Zebrafish: A Potential Community Outreach Program; Page 7 Hospital Appointments; Page 10 Match Day; Page 12 Profile: Urologic Surgery’s “Real Deal”; Page 14 Profile: When Terror Hit the Pentagon, Stephen Frost’s Reaction Was: Tend the Injured; Page 16 Profile: Searching for the Cause of the Rash That’s Itching Pupils; Page 17 In Memoriam; Page 18 Class Notes; Page 19 Building on Knowledge of Angiogenesis, Invention Provides Hope to the Obese; Page 22 Griffith Heads …


Evaluation Of A Comprehensive Diabetes Disease Management Program: Progress In The Struggle For Sustained Behavior Change, Janice Clarke, Albert Crawford, David B. Nash Jun 2002

Evaluation Of A Comprehensive Diabetes Disease Management Program: Progress In The Struggle For Sustained Behavior Change, Janice Clarke, Albert Crawford, David B. Nash

College of Population Health Faculty Papers

The successful management of diabetes with a goal of achieving near-normoglycemia requires patients to make multiple lifestyle changes as part of an intensive, complex, and coordinated therapeutic regimen aimed at reducing the risk of complications associated with the disease. The difficulty in creating and sustaining these lifestyle behavior changes is a major stumbling block in achieving the desired therapeutic goal. An underlying assumption of comprehensive disease management is that regular, personal contact with nurses and ancillary health professionals will facilitate these lifestyle behavior changes for program participants. The results of a survey of self-reported data from 750 participants in a …


Stretch-Induced Calcium Release In Smooth Muscle., Guangju Ji, Robert J Barsotti, Morris E Feldman, Michael I Kotlikoff Jun 2002

Stretch-Induced Calcium Release In Smooth Muscle., Guangju Ji, Robert J Barsotti, Morris E Feldman, Michael I Kotlikoff

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Smooth muscle cells undergo substantial increases in length, passively stretching during increases in intraluminal pressure in vessels and hollow organs. Active contractile responses to counteract increased transmural pressure were first described almost a century ago (Bayliss, 1902) and several mechanisms have been advanced to explain this phenomenon. We report here that elongation of smooth muscle cells results in ryanodine receptor-mediated Ca(2+) release in individual myocytes. Mechanical elongation of isolated, single urinary bladder myocytes to approximately 120% of slack length (DeltaL = 20) evoked Ca(2+) release from intracellular stores in the form of single Ca(2+) sparks and propagated Ca(2+) waves. Ca(2+) …


Characterization Of Subcellular Localization And Stability Of A Splice Variant Of G Alpha I2., Philip B Wedegaertner May 2002

Characterization Of Subcellular Localization And Stability Of A Splice Variant Of G Alpha I2., Philip B Wedegaertner

Department of Microbiology and Immunology Faculty Papers

BACKGROUND: Alternative mRNA splicing of alpha(i2), a heterotrimeric G protein alpha subunit, has been shown to produce an additional protein, termed salpha(i2). In the salpha(i2) splice variant, 35 novel amino acids replace the normal C-terminal 24 amino acids of alpha(i2). Whereas alpha(i2) is found predominantly at cellular plasma membranes, salpha(i2) has been localized to intracellular Golgi membranes, and the unique 35 amino acids of salpha(i2) have been suggested to constitute a specific targeting signal. RESULTS: This paper proposes and examines an alternative hypothesis: disruption of the normal C-terminus of alpha(i2) produces an unstable protein that fails to localize to plasma …


Bylaws Of The Jefferson College Of Graduate Studies Of Thomas Jefferson University, Jefferson College Of Graduate Studies Apr 2002

Bylaws Of The Jefferson College Of Graduate Studies Of Thomas Jefferson University, Jefferson College Of Graduate Studies

JCGS Administrative Documents & Policies

No abstract provided.


The Review - Spring 2002 Apr 2002

The Review - Spring 2002

Jefferson Review

IN THIS ISSUE

  • 1 - Message From The Dean
  • 2 - Best Wishes to Dr. Kraemer
  • 3 - Patriotism Runs High With Alumni
  • 3 - It’s What We Do
  • 4 - A Fond Farewell to Dean Larry Abrams
  • 6 - Reflecting Upon the Past...Defining the Future
  • 8 - Alumni Update
  • 10 - The Place to Be...Jefferson CHP!
  • 13 - Time To Go Site-Seeing!


Penn Macy Initiative To Advance Academic Nursing Practice, Norma M. Lang Phd, Rn, Faan, Frcn, Lois K. Evans Dnsc, Rn, Faan, Beth Ann Swan Phd, Crnp Mar 2002

Penn Macy Initiative To Advance Academic Nursing Practice, Norma M. Lang Phd, Rn, Faan, Frcn, Lois K. Evans Dnsc, Rn, Faan, Beth Ann Swan Phd, Crnp

College of Nursing Faculty Papers & Presentations

Academic nursing practice holds great promise for the future of the nursing discipline. The successful and intentional integration of the tripartite mission of research, education, and clinical practice can facilitate both the evolution of the science and implementation of evidence-based practice, while imbuing practitioners in the making with the world of the possible. Although many schools of nursing have been involved in some aspects of academic practice, the lack of common focus and direction has hampered concerted movement. The Penn Macy Initiative was conceived as a vehicle to help build and coalesce the critical mass needed to bridge this gap. …


Circulating Testosterone And Prostate-Specific Antigen In Nipple Aspirate Fluid And Tissue Are Associated With Breast Cancer., Edward R Sauter, David S Tichansky, Inna Chervoneva, Eleftherios P Diamandis Mar 2002

Circulating Testosterone And Prostate-Specific Antigen In Nipple Aspirate Fluid And Tissue Are Associated With Breast Cancer., Edward R Sauter, David S Tichansky, Inna Chervoneva, Eleftherios P Diamandis

Department of Surgery Faculty Papers

Preliminary evidence has associated testosterone and prostate-specific antigen (PSA) with breast cancer. Our objective was to determine whether a) testosterone levels in nipple aspirate fluid (NAF), serum, or breast tissue are associated with breast cancer; b) testosterone levels in serum are associated with levels in NAF; c) PSA in NAF, serum, or breast tissue is associated with breast cancer; and d) serum PSA is associated with NAF PSA levels. We obtained 342 NAF specimens from 171 women by means of a modified breast pump. Additionally, we collected 201 blood samples from 99 women and 51 tissue samples from 41 subjects …


Measuring Health Status And Quality Of Life In Disease Management Programs, Dea Belazi Mar 2002

Measuring Health Status And Quality Of Life In Disease Management Programs, Dea Belazi

College of Population Health Faculty Papers

Current medical practice is largely disease and problem focused, concentrating on the diagnosis and treatment of anatomic or physiologic problems. This approach assumes that physiologic parameters accurately reflect the patient's status of health. It also assumes that, when a patient's disease is ameliorated, his or her quality of life will improve. Many health services researchers find these parameters to be imperfect determinates for good outcomes of patients' perceived health status. However, there are many valid and reliable methods to measure patients' health status and quality of life. Recently available survey tools that measure quality of life are based on modern …


Jefferson Alumni Bulletin - Volume 51, Number 2, March 2002 Mar 2002

Jefferson Alumni Bulletin - Volume 51, Number 2, March 2002

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 51, Number 2, March 2002 Mark Your Calendar; Page 2 Listening In: Lectures on Campus; Page 2 Building a Multicultural Community; Page 4 Jefferson Hosts SNMA Conference; Page 7 New Alumni President Wilfreta Baugh; Page 8 Report from the Alumni Trustees; Page 9 Alumni Spotlight: Al Heath ’57; Page 9 Sebastianelli Named President of the Jefferson Health System; Page 10 Jefferson’s Approach to Monitoring Clinical Education is the Focus of JAMA Article; Page 11 Nothing Fishy About this Research; Page 14 Class Notes; Page 15 In Memoriam; Page 16 Photos of Yemen Evoke a Beautiful …


Reduction In The Incidence Of Type 2 Diabetes With Lifestyle Intervention Or Metformin., William C. Knowler, Elizabeth Barrett-Connor, Sarah E. Fowler, Richard F. Hamman, John M. Lachin, Elizabeth A. Walker, David M. Nathan, P. G. Watson, J. T. Mendoza, K. A. Smith, J. Caro, B. Goldstein, C. Lark, L. Menefee, L. Murphy, C. Pepe, J. M. Spandorfer Feb 2002

Reduction In The Incidence Of Type 2 Diabetes With Lifestyle Intervention Or Metformin., William C. Knowler, Elizabeth Barrett-Connor, Sarah E. Fowler, Richard F. Hamman, John M. Lachin, Elizabeth A. Walker, David M. Nathan, P. G. Watson, J. T. Mendoza, K. A. Smith, J. Caro, B. Goldstein, C. Lark, L. Menefee, L. Murphy, C. Pepe, J. M. Spandorfer

Department of Medicine Faculty Papers

BACKGROUND: Type 2 diabetes affects approximately 8 percent of adults in the United States. Some risk factors--elevated plasma glucose concentrations in the fasting state and after an oral glucose load, overweight, and a sedentary lifestyle--are potentially reversible. We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes.

METHODS: We randomly assigned 3234 nondiabetic persons with elevated fasting and post-load plasma glucose concentrations to placebo, metformin (850 mg twice daily), or a lifestyle-modification program with the goals of at least a 7 percent weight loss and at least …


Medical, Social And Legal Implications Of Treating Nausea And Vomiting Of Pregnancy, Robert L. Brent Jan 2002

Medical, Social And Legal Implications Of Treating Nausea And Vomiting Of Pregnancy, Robert L. Brent

The Selected Works of Robert Brent

This article will deal with medical, social, and legal implications of treating nausea and vomiting of pregnancy (NVP). Clinical problems occur when the symptoms become exaggerated and result in debilitation, dehydration, and hospitalization. The treatment of NVP in its early stages has the implication that it will prevent the more serious complications, including hospitalization. Therapeutic modalities discussed in this conference that have been used or are being tested are primarily symptomatic treatments (antihistamines, Bendectin (Merrell Dow; Cincinatti, Ohio), phenothiazines, hyponosis, accupressure, relaxation behavioral modification, audiogenic feedback training, newer medications, diet, and nutritional support). Bendectin is probably the most studied medication …