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Articles 3331 - 3360 of 8080
Full-Text Articles in Medicine and Health Sciences
Biliary Stenting In Difficult Common Bile Duct Stones: A Single Tertiary Center Experience, Mahmut Yüksel, Selçuk Di̇şi̇beyaz, Mustafa Kaplan, Erkan Parlak, Hakan Yildiz, İhsan Ateş, Ertuğrul Kayaçeti̇n
Biliary Stenting In Difficult Common Bile Duct Stones: A Single Tertiary Center Experience, Mahmut Yüksel, Selçuk Di̇şi̇beyaz, Mustafa Kaplan, Erkan Parlak, Hakan Yildiz, İhsan Ateş, Ertuğrul Kayaçeti̇n
Turkish Journal of Medical Sciences
Background/aim: We aimed to examine the effect of plastic biliary stenting in the treatment of common bile duct (CBD) stones. Materials and methods: The data of 13,034 patients in our unit who had endoscopic retrograde cholangiopancreatography (ERCP) between 2008 and 2015 were scanned retrospectively. Results: A biliary stent was placed in 61 of 74 patients. While the plastic biliary stent was placed in patients, the mean stone size after the 1st ERCP was 20 mm and the bile duct size was 13 mm. At the time of the 2nd ERCP conducted approximately 73.9 days later, the mean stone size was …
Segmental Epidural Anesthesia For Percutaneous Kyphoplasty:Comparison With General Anesthesia, Alparslan Apan, Özgün Cuvaş Apan, Emi̇ne Arzu Köse
Segmental Epidural Anesthesia For Percutaneous Kyphoplasty:Comparison With General Anesthesia, Alparslan Apan, Özgün Cuvaş Apan, Emi̇ne Arzu Köse
Turkish Journal of Medical Sciences
Background/aim: This is a feasibility study evaluating whether segmental epidural anesthesia is an alternative anesthetic approach to general anesthesia for percutaneous kyphoplasty. Materials and methods: After ethics committee approval was obtained, 52 ASA class I-III patients scheduled for elective, single-level percutaneous kyphoplasty were recruited. The patients were divided into two equal groups. In Group E (Group Epidural) segmental epidural anesthesia was performed using the loss of resistance technique with saline. In Group G (Group Control) general anesthesia was performed. Hemodynamic parameters, intraoperative and postoperative analgesic requirements, visual analogue scale (VAS) scores, length of stay in the postanesthesia care unit (PACU), …
Surgical Management Of Large-Cell Neuroendocrinelung Carcinoma: An Analysis Of 25 Cases, Funda İncekara, Koray Aydoğdu, Ebru Sayilir, Seli̇m Şaki̇r Erkmen Gülhan, Funda Demi̇rağ, Sadi̇ Kaya, Göktürk Findik
Surgical Management Of Large-Cell Neuroendocrinelung Carcinoma: An Analysis Of 25 Cases, Funda İncekara, Koray Aydoğdu, Ebru Sayilir, Seli̇m Şaki̇r Erkmen Gülhan, Funda Demi̇rağ, Sadi̇ Kaya, Göktürk Findik
Turkish Journal of Medical Sciences
Background/aim: Large-cell neuroendocrine carcinoma (LCNEC) of the lung is a relatively uncommon and aggressive subset of pulmonary neuroendocrine tumors, which include typical and atypical carcinoid, and small-cell lung cancer. LCNEC of the lung accounts for no more than 1% of all lung cancers. LCNECs show features of high-grade neuroendocrine tumors and patients with LCNEC have a very poor prognosis. Materials and methods: Twenty-five patients (22 males and 3 females; mean years 60.7; range 48 to 77 years) who underwent pulmonary resection for large-cell neuroendocrine carcinoma between January 2004 and December 2014 were investigated retrospectively. Results: Type of surgery, pathologic TNM …
Comparison Of The Distinctive Pathological Features Of And P16 And C-Kitexpression Levels In Benign And Malignant Endometrial Polyps, Nermi̇n Koç, Selçuk Ayas, Lütfi̇ye Uygur, Nurver Özel Özbay
Comparison Of The Distinctive Pathological Features Of And P16 And C-Kitexpression Levels In Benign And Malignant Endometrial Polyps, Nermi̇n Koç, Selçuk Ayas, Lütfi̇ye Uygur, Nurver Özel Özbay
Turkish Journal of Medical Sciences
Background/aim: Histopathological examination is crucial for the effective management of endometrial polyps. Immunohistochemical markers such as p16 and c-Kit may facilitate the differential diagnoses of benign and malignant polyps. The aim of the present study was to explore the expression levels of c-Kit (CD117) and p16 in endometrial polyps of postmenopausal women. Materials and methods: Twenty-five hysterectomy specimens with malignant endometrial polyps and hysterectomy or polypectomy specimens featuring 55 benign polyps were studied. The polyps were immunohistochemically stained for p16 and c-Kit, and differences in the expression levels of these proteins in the glandular and stromal components of benign polyps …
Comparison Of Wire-Guided Localization And Radio-Guided Occult Lesionlocalization In Preoperative Localization Of Nonpalpable Breast Lesions, Nazim Bariş Kanat, Murat Tuncel, Tamer Aksoy, Ayşegül Firat, Fi̇gen Demi̇rkazik, Demi̇rali̇ Onat, Meltem Çağlar Tuncali, Bi̇ray Emi̇ne Caner
Comparison Of Wire-Guided Localization And Radio-Guided Occult Lesionlocalization In Preoperative Localization Of Nonpalpable Breast Lesions, Nazim Bariş Kanat, Murat Tuncel, Tamer Aksoy, Ayşegül Firat, Fi̇gen Demi̇rkazik, Demi̇rali̇ Onat, Meltem Çağlar Tuncali, Bi̇ray Emi̇ne Caner
Turkish Journal of Medical Sciences
Background/aim: Breast lesions that are not palpable on physical examination but considered suspicious for malignancy on mammography or ultrasonography should be marked before surgery. Wire-guided localization (WGL) is the most frequently used method for preoperative marking of nonpalpable breast lesions (NPBLs). An alternative is marking by a radioactive agent (radio-guided occult lesion localization; ROLL). The present study aimed to compare WGL and ROLL for preoperative marking. Materials and methods: The study included 25 patients marked by ROLL and 11 patients marked by WGL. The groups were compared in terms of patient and lesion characteristics, method-related characteristics, hospital stay duration, complications, …
The Factors Affecting Survival In Patients With Bronchiectasis, Fatma Çi̇ftci̇, Eli̇f Şen, Sevgi̇ Behi̇ye Saryal, Zeynep Pinar Önen, Banu Gülbay, Öznur Yildiz, Turan Acican, Gülseren Karabiyikoğlu
The Factors Affecting Survival In Patients With Bronchiectasis, Fatma Çi̇ftci̇, Eli̇f Şen, Sevgi̇ Behi̇ye Saryal, Zeynep Pinar Önen, Banu Gülbay, Öznur Yildiz, Turan Acican, Gülseren Karabiyikoğlu
Turkish Journal of Medical Sciences
Background/aim: There is limited information about the rate and modifiers of mortality in noncystic fibrosis bronchiectasis. Materials and methods: This study enrolled a total of 56 bronchiectasis patients. Patients' body mass index, smoking habit, previous therapies, comorbid disorders, history of vaccination, bronchiectasis type and radiological extent, arterial blood gas analysis, respiratory function tests, and laboratory results were recorded. Results: After a follow-up of 65.38 ± 18.62 months the overall mortality rate was 35.7%. The mean survival duration was 46.42 ± 8.25 months. Advanced age significantly increased mortality (HR: 2.031; CI: 0.991?4.072, P = 0.035). A significant correlation was found between …
Do Anxiety And Depression Statuses Differ In Differentpolycystic Ovary Syndrome Phenotypes?, Derya Akdağ Ci̇ri̇k, Berna Di̇lbaz, Sezi̇n Ertürk Aksakal, Zeynep Kotan, Runa Özelçi̇, Funda Akpinar, Leyla Mollamahmutoğlu
Do Anxiety And Depression Statuses Differ In Differentpolycystic Ovary Syndrome Phenotypes?, Derya Akdağ Ci̇ri̇k, Berna Di̇lbaz, Sezi̇n Ertürk Aksakal, Zeynep Kotan, Runa Özelçi̇, Funda Akpinar, Leyla Mollamahmutoğlu
Turkish Journal of Medical Sciences
Background/aim: To evaluate psychological parameters and health quality profiles in women with reproductive polycystic ovary syndrome (PCOS) phenotypes and age matched controls. Materials and methods: The study groups included 101 women with PCOS (54 with the National Institutes of Health [NIH] phenotype and 47 with the non-NIH phenotype) and 49 healthy female controls. The participants completed anxiety and depression scales and four quality of life domains. Results: We identified the women with PCOS as having a 3.39 times increased risk for depression (subscale ≥ 7) and a 3.64 times increased risk for anxiety (subscale ≥ 10) compared to the controls. …
New Immunohistochemical Markers In The Differential Diagnosisof Nonsmall Cell Lung Carcinoma, Ferda Bi̇r, Duygu Çeli̇ker, Bi̇nnaz Fatma Evyapan, Arzu Yaren, Tamer Edi̇rne
New Immunohistochemical Markers In The Differential Diagnosisof Nonsmall Cell Lung Carcinoma, Ferda Bi̇r, Duygu Çeli̇ker, Bi̇nnaz Fatma Evyapan, Arzu Yaren, Tamer Edi̇rne
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate Napsin-A, NTRK-1, NTRK-2, Desmoglein-3, and Desmocollin-3 in the differential diagnosis and prognosis of nonsmall cell lung cancer. Materials and methods: The expression of Napsin-A, NTRK-1, NTRK-2, and Desmoglein-3 was examined by immunohistochemistry in 50 squamous cell carcinomas and 50 adenocarcinomas. Desmocollin-3 was investigated in 29 squamous cell carcinoma and 29 adenocarcinoma cases. Associations between expression profiles of Napsin-A, NTRK-1, NTRK-2, Desmoglein-3, and Desmocollin-3 in lung cancers and clinicopathological variables were analyzed. Results: Napsin-A staining was statistically significant in detecting adenocarcinomas versus squamous cell carcinomas. The sensitivity of Napsin-A for adenocarcinomas was …
Importance Of Sonographic Paratracheal Lymph Node Evaluationin Early Autoimmune Thyroiditis, Tuğrul Örmeci̇, Mukaddes Çolakoğullari, İsrafi̇l Orhan, Bayram Ufuk Şakul
Importance Of Sonographic Paratracheal Lymph Node Evaluationin Early Autoimmune Thyroiditis, Tuğrul Örmeci̇, Mukaddes Çolakoğullari, İsrafi̇l Orhan, Bayram Ufuk Şakul
Turkish Journal of Medical Sciences
Background/aim: To review the sonographic views of paratracheal lymph nodes (PLNs) in the diagnosis and during different stages of autoimmune thyroiditis. Materials and methods: Features of the PLNs (left and right), thyroid sonography, and laboratory data were investigated in 126 cases. Patients were divided into three groups by using thyroid sonographic criteria in the literature (group 1: control, group 2: early-stage/indeterminate, group 3: definite thyroiditis). Indeterminate patients were followed up for 1 year and included as indeterminate/early-stage thyroiditis patients. Results: Percentage of right and left PLN was 13.3% and 46.2% in control cases, 21.2% and 80% in early-stage/indeterminate cases, and …
Association Of Neutrophil/Lymphocyte Ratio With The Degree Ofinterstitial Lung Disease In Systemic Sclerosis, Nurhan Ati̇lla, Gözde Yildirim Çeti̇n, Ayşe Balkarli
Association Of Neutrophil/Lymphocyte Ratio With The Degree Ofinterstitial Lung Disease In Systemic Sclerosis, Nurhan Ati̇lla, Gözde Yildirim Çeti̇n, Ayşe Balkarli
Turkish Journal of Medical Sciences
Background/aim: Determining the severity of systemic sclerosis related interstitial lung disease (SSc-ILD) is based on clinical and radiological findings, inflammation marker levels, and carbon monoxide diffusing capacity of the lung (DLCO). Recently studies are ongoing for objective and easy markers. Neutrophil/lymphocyte ratio (NLR) is shown to be a good marker for inflammation in recent clinical trials. In this study, we aimed to identify the possible relationship between NLR and carbon monoxide transfer coefficient (KCO) of SSc-ILD patients. Materials and methods: Fifty-nine patients with systemic sclerosis (SSc) were enrolled in the study. We used high-resolution computed tomography for diagnosis and used …
Exploring Cyp2b6 Activity By Measuring The Presence Ofnevirapine Hydroxy Metabolites In Plasma, Suzana Mustafa, Norul Badriah Hassan, Soo Choon Tan, Mahiran Mustafa, Ahmad Kashfi Ab Rahman, Lee Lee Low, Wan Nazirah Wan Yusuf
Exploring Cyp2b6 Activity By Measuring The Presence Ofnevirapine Hydroxy Metabolites In Plasma, Suzana Mustafa, Norul Badriah Hassan, Soo Choon Tan, Mahiran Mustafa, Ahmad Kashfi Ab Rahman, Lee Lee Low, Wan Nazirah Wan Yusuf
Turkish Journal of Medical Sciences
Background/aim: Nevirapine is a reverse-transcriptase inhibitor widely used in combination therapy to treat HIV infection. Nevirapine is extensively metabolized in the liver and CYP2B6 is mainly responsible for oxidation of 3-hydroxynevirapine (3-OH NVP). This study aims to explore CYP2B6 activity by measuring 2-hydroxynevirapine (2-OH NVP) and 3-OH NVP in plasma and to identify factors associated with nevirapine pharmacokinetic parameters. Materials and methods: A total of 112 patients were recruited and treated with nevirapine-based antiretroviral therapy. Plasma nevirapine and metabolite concentrations were assayed using high-performance liquid chromatography via liquid-liquid extraction. Results: Thirty-nine (34.8%) of the patients had no 3-OH NVP detected …
Peripheral Flt-3 Ligand Levels As A Pathobiological Parameter Duringthe Clinical Course Of Acute Myeloid Leukemia, Memduh Şahi̇n, İbrahi̇m Celaletti̇n Haznedaroğlu, Demi̇rcan Özbalci
Peripheral Flt-3 Ligand Levels As A Pathobiological Parameter Duringthe Clinical Course Of Acute Myeloid Leukemia, Memduh Şahi̇n, İbrahi̇m Celaletti̇n Haznedaroğlu, Demi̇rcan Özbalci
Turkish Journal of Medical Sciences
Background/aim: FLT-3 ligand is a growth factor affecting the hematopoietic lineage. The aim of this study was to evaluate the variability of peripheral FLT-3 ligand during the clinical course of acute myeloid leukemia (AML) patients. Materials and methods: Twenty-four patients were enrolled in this study in order to assess alterations in the circulating levels of FLT-3 ligand during the clinical course of AML. Results: We studied the association in the diagnostic period between the FLT-3 ligand and peripheral blood cells together with serum electrolytes. FLT-3 ligand levels (pg/mL) during the aplastic period due to remission induction and consolidation were higher …
Growing Oxa-23 Type Strains Among Carbapenem-Resistant Acinetobacter Baumannii And Tigecycline As An Alternate Combination Therapy, Şeri̇fe Altun, Zeli̇ha Koçak Tufan, Belgi̇n Altun, Ufuk Önde, Sami̇ Kinikli, Ali̇ Pekcan Demi̇röz
Growing Oxa-23 Type Strains Among Carbapenem-Resistant Acinetobacter Baumannii And Tigecycline As An Alternate Combination Therapy, Şeri̇fe Altun, Zeli̇ha Koçak Tufan, Belgi̇n Altun, Ufuk Önde, Sami̇ Kinikli, Ali̇ Pekcan Demi̇röz
Turkish Journal of Medical Sciences
Background/aim: The increasing prevalence and global spread of difficult-to-treat carbapenem-resistant Acinetobacter baumannii has become a serious problem. The aim of this study is to investigate the resistance patterns and tigecycline sensitivity of carbapenem-resistant A. baumannii strains. Materials and methods: Acinetobacter strains that were carbapenem-resistant and collected mainly from intensive care units were included into this study. The antibiotic sensitivity/resistance of the strains to other antibiotics and tigecycline were noted. Presence of blaOXA-23, blaOXA-48, blaOXA58, and NDM-1 was investigated by PCR. Results: In total, 44 carbapenem-resistant A. baumannii strains were detected. In addition, 57% (25/44) showed resistance to netilmicin and 2% …
The Effect Of Basolateral Amygdala Nucleus Lesion On Memory Under Acute,Mid And Chronic Stress In Male Rats, Hoda Ranjbar, Maryam Radahmadi, Hojjatallah Alaei, Parham Reisi, Sara Karimi
The Effect Of Basolateral Amygdala Nucleus Lesion On Memory Under Acute,Mid And Chronic Stress In Male Rats, Hoda Ranjbar, Maryam Radahmadi, Hojjatallah Alaei, Parham Reisi, Sara Karimi
Turkish Journal of Medical Sciences
Background/aim: The basolateral amygdala (BLA) modulates memory for emotional events and is involved in both stress and memory. This study investigated different durations of stress and the role of BLA on serum corticosterone level and spatial and cognitive memory. Materials and methods: Different durations of stress (acute, mid, and chronic stress), with and without BLA lesion were induced in rats by 6 h/day restraint stress for 1, 7, and 21 days. Memory functions were evaluated by novel object recognition (NOR) and object location test (OLT). Results: The OLT findings showed locomotor activity and spatial memory slightly decreased with different durations …
Chrysin Prevents Brain Damage Caused By Global Cerebralischemia/Reperfusion In A C57bl/J6 Mouse Model, Mehmet Aki̇f Durak, Mustafa Namik Öztanir, Neşe Başak Türkmen, Osman Çi̇ftçi̇, Asli Taşlidere, Mehmet Tecelli̇oğlu, Ari̇f Önder
Chrysin Prevents Brain Damage Caused By Global Cerebralischemia/Reperfusion In A C57bl/J6 Mouse Model, Mehmet Aki̇f Durak, Mustafa Namik Öztanir, Neşe Başak Türkmen, Osman Çi̇ftçi̇, Asli Taşlidere, Mehmet Tecelli̇oğlu, Ari̇f Önder
Turkish Journal of Medical Sciences
Background/aim: The present study investigated the neuroprotective effects of chrysin (CRS) following global cerebral ischemia and reperfusion (I/R) in a C57BL/J6 mouse model. Materials and methods: A total of 40 mice were equally divided into four groups: (1) sham-operated (SH = control), (2) global cerebral I/R (I/R), (3) CRS, and (4) CRS + I/R. In the I/R group, the bilateral carotid arteries were clipped for 15 min and the mice were treated with vehicle (corn oil) for 10 days. In the CRS group, CRS (50 mg/kg) was given for 10 days without carotid occlusion. In the CRS + I/R group …
Emergency Department Visits Caused By Adverse Drug Reactions: Results Of Aturkish University Hospital, Mehmet Can Gi̇rgi̇n, Sedat Yanturali, Mualla Ayli̇n Arici, Neşe Çolak Oray, Özgür Doylan, Yücel Demi̇ral, Yeşi̇m Tunçok
Emergency Department Visits Caused By Adverse Drug Reactions: Results Of Aturkish University Hospital, Mehmet Can Gi̇rgi̇n, Sedat Yanturali, Mualla Ayli̇n Arici, Neşe Çolak Oray, Özgür Doylan, Yücel Demi̇ral, Yeşi̇m Tunçok
Turkish Journal of Medical Sciences
Background/aim: We aimed to evaluate adverse drug reaction (ADR)-related emergency department (ED) visits in the ED of the Dokuz Eylül University Hospital prospectively. Materials and methods: Patients who were admitted to the ED during 1-week periods of four different seasons between July 2010 and April 2011 were enrolled. Demographics of patients, previous ADR history, clinical progress, and outcomes were recorded. Causality assessment was done according to World Health Organization Uppsala Monitoring Centre categories. ADRs were categorized as certain, probable, or possible. Results: Patients who were on medications (26.5%, n = 1838) were evaluated for ADR-related ED admissions. ADRs accounted for …
Health Promotion Lifestyle Profile Scores Are Not Associatedwith Obesity In High School Students, Gi̇zem Li̇mni̇li̇, Ni̇lgün Özçakar, Mehtap Kartal
Health Promotion Lifestyle Profile Scores Are Not Associatedwith Obesity In High School Students, Gi̇zem Li̇mni̇li̇, Ni̇lgün Özçakar, Mehtap Kartal
Turkish Journal of Medical Sciences
Background/aim: Obesity is a cause of preventable morbidity and mortality with an increasing prevalence. Health promoting lifestyle activities maintain or improve an individual?s health and in adolescence many habits are configured. The aim of this study was to determine the prevalence of overweight and obesity among adolescents and the relation between obesity and health promoting behaviors. Materials and methods: This is a cross-sectional study including 848 high school students aged 15?17. All students were administered a questionnaire including the Health Promotion Life-Style Profile Scale. Weight and height were measured and body mass index was calculated. Descriptive analysis, Pearson?s chi-square test, …
The Efficacy Of A Through-The-Scope Sodium Phosphate Solution With Completion Colonoscopy On The Same Day As A Salvage Option For Inadequate Bowel Cleansing, Mehmet İbi̇ş, İbrahi̇m Koral Önal, Mehmet Arhan, Tarkan Karakan, Eylem Karatay, Özlem Gül Utku, Harun Erdal, İbrahi̇m Doğan
The Efficacy Of A Through-The-Scope Sodium Phosphate Solution With Completion Colonoscopy On The Same Day As A Salvage Option For Inadequate Bowel Cleansing, Mehmet İbi̇ş, İbrahi̇m Koral Önal, Mehmet Arhan, Tarkan Karakan, Eylem Karatay, Özlem Gül Utku, Harun Erdal, İbrahi̇m Doğan
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the efficacy of a through- the-scope sodium phosphate solution with completion colonoscopy on the same day as a salvage option for inadequate bowel preparation Materials and methods: All participants were instructed to eat a low residual diet for 3 days before the scheduled colonoscopy and a clear liquid diet 18 h before the colonoscopy. The patients were asked to take split doses of an oral sennoside solution at 1800 and 2200 in the evening before the colonoscopy. In cases of inadequate bowel preparation detected during routine colonoscopy, a sodium phosphate solution …
Coexistence Of Preeclampsia And Inherited Thrombophilia In Turkish Pregnant Women, Mehtap Polat, Ebru Hacer Bi̇beroğlu, İsmai̇l Güler, Ömer Kutay Bi̇beroğlu
Coexistence Of Preeclampsia And Inherited Thrombophilia In Turkish Pregnant Women, Mehtap Polat, Ebru Hacer Bi̇beroğlu, İsmai̇l Güler, Ömer Kutay Bi̇beroğlu
Turkish Journal of Medical Sciences
Background/aim: To examine the relationship of inherited thrombophilia and other thrombotic risk factors with preeclampsia (PE) in a population of pregnant Turkish women. Materials and methods: This was a case cross-sectional study in which 70 women with PE and 60 normal pregnant women were studied to find out the frequency of women with risk factors including inherited thrombophilia among preeclamptic cases. Results: Hemoglobin, platelet count, uric acid, vitamin B12, folic acid, copper, homocysteine, plasminogen activator inhibitor-1, fibrinogen, protein S, protein C, activated protein C resistance values show significant differences in women with PE in comparison to women with normal pregnancy. …
Transesophageal Echocardiography Experience In Thepediatric Age Group In A Tertiary Cardiac Center, Peli̇n Ayyildiz, Alper Güzeltaş, İbrahi̇m Cansaran Tanidir, Taner Kasar, Erkut Öztürk, Yakup Ergül
Transesophageal Echocardiography Experience In Thepediatric Age Group In A Tertiary Cardiac Center, Peli̇n Ayyildiz, Alper Güzeltaş, İbrahi̇m Cansaran Tanidir, Taner Kasar, Erkut Öztürk, Yakup Ergül
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to evaluate the transesophageal echocardiography (TEE) findings of pediatric patients in a tertiary center where complex congenital heart surgery and interventional procedures have been performed. Materials and methods: All TEE studies performed between December 2009 and December 2014 were reviewed retrospectively. Patients were divided into 3 groups: perioperative, during interventional procedures, and due to other reasons. Demographic features, transthoracic echocardiography (TTE) reports, TEE reports, change in decision after TEE evaluation, and related complications were recorded. Results: A total of 703 patients who had TEE evaluation were included in the study; 51% were female …
Proliferation And Differentiation Markers Of Colorectal Adenocarcinomaand Their Correlation With Clinicopathological Factors, Olivera Mitrovic Ajtic, Slobodan Todorovic, Milos Diklic, Tijana Suboticki, Bojana Beleslin-Cokic, Gordana Jovcic, Vladan Cokic
Proliferation And Differentiation Markers Of Colorectal Adenocarcinomaand Their Correlation With Clinicopathological Factors, Olivera Mitrovic Ajtic, Slobodan Todorovic, Milos Diklic, Tijana Suboticki, Bojana Beleslin-Cokic, Gordana Jovcic, Vladan Cokic
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to investigate proliferation and differentiation markers in colorectal adenocarcinoma and their correlation with clinicopathological factors. Materials and methods: Samples were collected from 38 patients with colorectal adenocarcinoma and 10 healthy controls. E-cadherin, carcinoembryonic antigen (mCEA), cyclin B1, vascular endothelial growth factor (VEGF), and erythropoietin (EPO) receptor (EPOR) were examined by immunohistochemistry; VEGF and EPO were examined by real-time PCR. Results: The tumor samples were mostly characterized by large dimension (pT3), moderate level of differentiation (G2), negative lymph node status (N0), and no metastasis. Cyclin B1 and VEGF gene and protein expressions were significantly …
Expression Of Maspin In Testis Tumors With Germ Cells Andits Relation With Angiogenesis Factors, Hüseyi̇n Çeli̇k, Tahsi̇n Turunç, Nebi̇l Bal, Eray Hasirci, Alaaddi̇n Akay, Çeti̇n Levent Peşki̇rci̇oğlu
Expression Of Maspin In Testis Tumors With Germ Cells Andits Relation With Angiogenesis Factors, Hüseyi̇n Çeli̇k, Tahsi̇n Turunç, Nebi̇l Bal, Eray Hasirci, Alaaddi̇n Akay, Çeti̇n Levent Peşki̇rci̇oğlu
Turkish Journal of Medical Sciences
Background/aim: We aimed to evaluate the importance of maspin expression in testicular tumors with germ cells, its effect on prognosis, and the relation with angiogenesis factors. Materials and methods: The paraffin blocks of the orchiectomy materials of 32 patients who had undergone orchiectomy due to testicular tumors were taken within the scope of the study. The specimens of the cases included in the study group were reexamined under light microscope. Results: While just one maspin-positive sample was found in the seminoma cases, maspin stained positively in 6 of the nonseminoma germ cell tumors (NSGCTs). No statistical difference was found between …
Effects Of Cepae Extract, Allantoin, And Heparin Mixture On Developing Andalready Formed Epidural Fibrosis In A Rat Laminectomy Model, Rafet Özay, Osman Yüksel Yavuz, Abi̇t Aktaş, Funda Yi̇ği̇t, Nuri̇ Eralp Çeti̇nalp, Haci Mustafa Özdemi̇r, Zeki̇ Şekerci̇
Effects Of Cepae Extract, Allantoin, And Heparin Mixture On Developing Andalready Formed Epidural Fibrosis In A Rat Laminectomy Model, Rafet Özay, Osman Yüksel Yavuz, Abi̇t Aktaş, Funda Yi̇ği̇t, Nuri̇ Eralp Çeti̇nalp, Haci Mustafa Özdemi̇r, Zeki̇ Şekerci̇
Turkish Journal of Medical Sciences
Background/aim: The study was designed to investigate whether local administration of a mixture composed of cepae extract, allantoin, and heparin (CAH) decreased already formed epidural fibrosis (EF) at the laminectomy site. Materials and methods: Twenty-four adult male Sprague Dawley rats were equally divided into four groups. Laminectomy was performed at the L5 level in all rats. The group 2 and group 4 rats were treated with local drug administration. While the group 1 and 2 rats were sacrificed after 6 weeks, the remaining rats were reoperated and CAH mixture was applied in group 4. The vertebral columns of all rats …
Effects Of Naloxone And Yohimbine In Polycystic Ovary Syndrome: A Rabbit Model Study, Sumera Sajjad, Sadia Tobassum, Umer Farooq, Husna Malik, Musadiq Idris
Effects Of Naloxone And Yohimbine In Polycystic Ovary Syndrome: A Rabbit Model Study, Sumera Sajjad, Sadia Tobassum, Umer Farooq, Husna Malik, Musadiq Idris
Turkish Journal of Medical Sciences
Background/aim: To assess the therapeutic effects of naloxone and yohimbine on polycystic ovary syndrome (PCOS) in a rabbit model in terms of body weight and endocrinological parameters (luteinizing hormone, insulin, and estradiol). Materials and methods: A total of 50 adult, reproductively mature female rabbits (Oryctolagus cuniculus) were divided into five groups (n = 10/group). In the control group PCOS was not induced (negative control group), whereas in the remaining four groups (n = 40) PCOS was induced with a single i.m. injection of testosterone daily and were designated as follows: positive control, naloxone-treated (NalT), yohimbine-treated (YohT), and naloxone+yohimbine-treated (NalYT) groups. …
Serum Lithium Levels Are Associated With White Blood Cell Counts In Bipolar Disorder, Murat İlhan Atagün, Şükrü Alperen Korkmaz, Çağlar Soykan, Derya Büyüköz, Serdar Süleyman Can, Ali̇ Çayköylü
Serum Lithium Levels Are Associated With White Blood Cell Counts In Bipolar Disorder, Murat İlhan Atagün, Şükrü Alperen Korkmaz, Çağlar Soykan, Derya Büyüköz, Serdar Süleyman Can, Ali̇ Çayköylü
Turkish Journal of Medical Sciences
No abstract provided.
Herbal Self-Medication Use In Type 2 Diabetes Mellitus, Yusuf Aydin, Eli̇f Önder
Herbal Self-Medication Use In Type 2 Diabetes Mellitus, Yusuf Aydin, Eli̇f Önder
Turkish Journal of Medical Sciences
No abstract provided.
The Relation Between Serum Cathepsin D Level And Carotid Intima-Media Thickness In Nondiabetic Hypertensive Patients, Ni̇hal Özkayar, Fatma Akyel, Ayşe Nurdan Barça, Serhan Vahi̇t Pi̇şki̇npaşa, Turan Turhan, İhsan Ateş, Fati̇h Dede
The Relation Between Serum Cathepsin D Level And Carotid Intima-Media Thickness In Nondiabetic Hypertensive Patients, Ni̇hal Özkayar, Fatma Akyel, Ayşe Nurdan Barça, Serhan Vahi̇t Pi̇şki̇npaşa, Turan Turhan, İhsan Ateş, Fati̇h Dede
Turkish Journal of Medical Sciences
Background/aim: We aimed to investigate the relation between carotid intima-media thickness (CIMT) and serum cathepsin D level in hypertensive patients. Materials and methods: This was a cross-sectional study of 74 hypertensive patients (22 males and 52 females, with a mean age of 51.86 ± 11.75 years). Serum levels of cathepsin D were measured with an enzyme-linked immunosorbent assay. CIMT measurements were taken from 3 different points: right and left common carotid arteries, bifurcation, and the first 2 cm of the internal carotid artery. Mean CIMT was calculated by averaging the measurements taken 3 times from each carotid artery. Results: Mean …
Recurrent Dilatation In Resistant Benign Esophageal Strictures: Timing Is Significant, Yasemi̇n Bi̇lgi̇n Büyükkarabacak, Ayşen Taslak Şengül, Mehmet Gökhan Pi̇rzi̇renli̇, Ahmet Başoğlu
Recurrent Dilatation In Resistant Benign Esophageal Strictures: Timing Is Significant, Yasemi̇n Bi̇lgi̇n Büyükkarabacak, Ayşen Taslak Şengül, Mehmet Gökhan Pi̇rzi̇renli̇, Ahmet Başoğlu
Turkish Journal of Medical Sciences
Background/aim: Benign esophageal strictures are frequently encountered pathologies occurring due to various reasons. Repeated dilatations may be needed, particularly in resistant strictures. This study aimed to evaluate patients who underwent repeated dilatations in our clinic due to resistant esophageal strictures. Materials and methods: Sixteen patients who underwent multiple dilatations in our clinic with the diagnosis of resistant benign esophageal stricture between 2007 and 2014 were studied for age, sex, etiology, symptoms, complications, number of dilatations, and intervals between dilatations. Under general anesthesia, all patients underwent dilatation with Savary-Gilliard bougie dilators with the help of rigid esophagoscopy. Results: In 10 of …
Evaluation Of Intraabdominal Hypertension And Genitofemoral Nerve Motor Conduction, Özlem Boybeyi̇, Elem İnal, Yasemi̇n Dere Günal, Mustafa Kemal Aslan, Gülümser Aydin, Tutku Soyer
Evaluation Of Intraabdominal Hypertension And Genitofemoral Nerve Motor Conduction, Özlem Boybeyi̇, Elem İnal, Yasemi̇n Dere Günal, Mustafa Kemal Aslan, Gülümser Aydin, Tutku Soyer
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to electrophysiologically evaluate the effect of increased intraabdominal pressure (IAP) on genitofemoral nerve (GFN) motor conduction. Materials and methods: Seven Wistar albino rats were included. After anesthetization, latency and duration of GFN conduction was recorded with a needle-probe at rest. IAP was increased to 15 mmHg by insufflating atmospheric air with a percutaneous intraperitoneal needle. At 30 min of IAP, GFN motor conduction was recorded. Abdominal pressure was then increased to 20 mmHg. At 60 min, GFN motor conduction was recorded again. The consecutive recordings of latency and duration of GFN conduction (rest, …
Frequency Of Twelve Carcinogenic Human Papilloma Virus Types Among Women From The South Backa Region, Vojvodina, Serbia, Gordana Kovacevic, Natasa Nikolic, Aleksandra Jovanovic-Galovic, Ivana Hrnjakovic-Cvjetkovic, Dusan Vuleta, Aleksandra Patic, Jelena Radovanov, Vesna Milosevic
Frequency Of Twelve Carcinogenic Human Papilloma Virus Types Among Women From The South Backa Region, Vojvodina, Serbia, Gordana Kovacevic, Natasa Nikolic, Aleksandra Jovanovic-Galovic, Ivana Hrnjakovic-Cvjetkovic, Dusan Vuleta, Aleksandra Patic, Jelena Radovanov, Vesna Milosevic
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine the presence and age distribution of different oncogenic human papilloma virus (HPV) types in women in the South Backa region and its relationship to Pap results. Materials and methods: In a group of 1087 women with normal and abnormal cytology, the commercial HR HPV Real-TM kit (Sacace Biotechnologies, Italy) was used. Results: Overall, 50.5% of the women were HPV positive. The presence of HPV types 18, 31, 51, and 58 was significantly influenced by age, while the presence of HPV types 16 and 45 was significantly influenced by cervical cytology. Results …