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Articles 3361 - 3390 of 8080
Full-Text Articles in Medicine and Health Sciences
Investigation Of Ischemia-Modified Albumin Levels And Some Atherosclerosis-Related Serum Parameters In Patients With Diabetic Foot, Sabahatti̇n Muhtaroğlu, Di̇dem Barlak Keti̇, Kürşad Ünlühi̇zarci
Investigation Of Ischemia-Modified Albumin Levels And Some Atherosclerosis-Related Serum Parameters In Patients With Diabetic Foot, Sabahatti̇n Muhtaroğlu, Di̇dem Barlak Keti̇, Kürşad Ünlühi̇zarci
Turkish Journal of Medical Sciences
Background/aim: To investigate serum ischemia-modified albumin (IMA), oxidized low-density lipoprotein (ox-LDL) levels, and paraoxonase 1 (PON1) activity in patients with diabetic foot. Materials and methods: Thirty patients with diabetes mellitus (DM), 30 patients with diabetic foot (29 and 27 of these patients had type 2 DM, respectively), and 30 healthy volunteers as the control group were included in the study. The patients with diabetic foot were divided into 2 groups, as those who had or had not undergone lower extremity amputation. Serum PON1 activity, ox-LDL, and IMA levels were measured. Results: Serum PON1 activity was lower (P < 0.05) and ox-LDL levels were higher (P < 0.05) in the diabetic foot group than in the control and diabetes groups. Albumin-adjusted IMA values were higher (P < 0.001) in the diabetic foot group compared to the diabetes group. The postamputation levels of IMA were decreased compared to the preamputation condition (P < 0.05). Conclusion: The low activity of PON1 and the high levels of ox-LDL and IMA may play an important role in the pathogenesis of diabetic foot. The use of these parameters in the follow-up of patients with DM may prevent the development of diabetic foot. In order to reach a definitive judgment, further studies with a larger number of subjects are necessary.
Impact Of Antimicrobial Drug Restrictions On Doctors? Behaviors, Oğuz Karabay, Sali̇h Hoşoğlu, Ertuğrul Güçlü, Şeri̇fe Akalin, Fatma Aybala Altay, Emsal Aydin, Bahadir Ceylan, Aygül Çeli̇k, İlhami̇ Çeli̇k, Tuna Demi̇rdal, Kezi̇ban Demi̇rli̇, Nuretti̇n Erben, Ünal Erkorkmaz, Serpi̇l Erol, Ömer Evi̇rgen
Impact Of Antimicrobial Drug Restrictions On Doctors? Behaviors, Oğuz Karabay, Sali̇h Hoşoğlu, Ertuğrul Güçlü, Şeri̇fe Akalin, Fatma Aybala Altay, Emsal Aydin, Bahadir Ceylan, Aygül Çeli̇k, İlhami̇ Çeli̇k, Tuna Demi̇rdal, Kezi̇ban Demi̇rli̇, Nuretti̇n Erben, Ünal Erkorkmaz, Serpi̇l Erol, Ömer Evi̇rgen
Turkish Journal of Medical Sciences
Background/aim: Broad-spectrum antibiotics have become available for use only with the approval of infectious disease specialists (IDSs) since 2003 in Turkey. This study aimed to analyze the tendencies of doctors who are not disease specialists (non-IDSs) towards the restriction of antibiotics. Materials and methods: A questionnaire form was prepared, which included a total of 22 questions about the impact of antibiotic restriction (AR) policy, the role of IDSs in the restriction, and the perception of this change in antibiotic consumption. The questionnaire was completed by each participating physician. Results: A total of 1906 specialists from 20 cities in Turkey participated …
Cost-Effectiveness Analysis Of Pemetrexed And Gemcitabine Treatment For Advanced Nonsmall Cell Lung Cancer In Turkey, Pinar Yalçin Balçik, Bayram Şahi̇n
Cost-Effectiveness Analysis Of Pemetrexed And Gemcitabine Treatment For Advanced Nonsmall Cell Lung Cancer In Turkey, Pinar Yalçin Balçik, Bayram Şahi̇n
Turkish Journal of Medical Sciences
Background/aim: The purpose of the study is to determine the cost-effectiveness of the chemotherapy medications that contain gemcitabine and pemetrexed, which are used in the treatment of advanced nonsmall cell lung cancer (NSCLC). Materials and methods: The study evaluated the effectiveness and cost of platinum-based pemetrexed and gemcitabine treatments as the first-line treatment of advanced NSCLC with the use of the Markov model, and from the perspective of the Social Security Institution. NSCLC costs calculated on the basis of experts' opinions and the effectiveness values calculated by administering the EQ-5D questionnaire to the patients were analyzed. All direct medical costs …
Effects And Mechanisms Of Curcumin On The Hemodynamic Variablesof Isolated Perfused Rat Hearts, Erkan Kilinç, Zi̇ya Kaygisiz, Bedri̇ Seli̇m Benek, Kenan Gümüşteki̇n
Effects And Mechanisms Of Curcumin On The Hemodynamic Variablesof Isolated Perfused Rat Hearts, Erkan Kilinç, Zi̇ya Kaygisiz, Bedri̇ Seli̇m Benek, Kenan Gümüşteki̇n
Turkish Journal of Medical Sciences
Background/aim: There is no information on the dose-response relationship of curcumin on the hemodynamic variables of the heart at the organ level in isolated perfused rat hearts. We aimed to investigate the effects and mechanisms of curcumin on the hemodynamic variables of isolated perfused rat hearts. Materials and methods: Rats were randomly divided into 9 groups. The isolated rat heart was retrogradely perfused with modified Krebs-Henseleit solution. After the stabilization period, each group was administered one of the following treatments for 25 min: saline, dimethyl sulfoxide, and curcumin (0.2 μM, 1 μM, and 5 μM); atropine (1 μM); atropine (1 …
Clarifying Aspects Of Noninvasive Mechanical Ventilation In Acute Exacerbations Of Chronic Obstructive Pulmonary Disease, Annia Schreiber, Antonio Esquinas
Clarifying Aspects Of Noninvasive Mechanical Ventilation In Acute Exacerbations Of Chronic Obstructive Pulmonary Disease, Annia Schreiber, Antonio Esquinas
Turkish Journal of Medical Sciences
No abstract provided.
Behçet Syndrome: The Vascular Cluster, Hasan Yazici, Emi̇re Seyahi̇
Behçet Syndrome: The Vascular Cluster, Hasan Yazici, Emi̇re Seyahi̇
Turkish Journal of Medical Sciences
No abstract provided.
Chronic Liver Diseases And Iron: A Concise Review With Emphasis On Hypotransferrinemia And Hypohepcidinemia, Naci̇ye Şemnur Büyükaşik, Yahya Büyükaşik
Chronic Liver Diseases And Iron: A Concise Review With Emphasis On Hypotransferrinemia And Hypohepcidinemia, Naci̇ye Şemnur Büyükaşik, Yahya Büyükaşik
Turkish Journal of Medical Sciences
No abstract provided.
The Relationship Of Mean Platelet Volume With Retinopathy In Type 2 Diabetes Mellitus, Asli Araz Güngör, Gül Gürsoy, Fati̇h Güngör, Seyi̇t Murat Bayram, Eray Atalay
The Relationship Of Mean Platelet Volume With Retinopathy In Type 2 Diabetes Mellitus, Asli Araz Güngör, Gül Gürsoy, Fati̇h Güngör, Seyi̇t Murat Bayram, Eray Atalay
Turkish Journal of Medical Sciences
Background/aim: Patients with diabetes mellitus have an increased risk of developing micro- and macrovascular complications. Retinopathy is one of the most important complications of diabetes whose pathophysiological cause has not yet been determined. One candidate may be platelet volume. In this study we aimed to investigate the association between mean platelet volume and diabetic retinopathy. Materials and methods: Mean platelet volume levels were investigated in type 2 diabetic patients with and without retinopathy, and in healthy participants. After reclassifying our diabetics in terms of the presence or absence of hypertension and hyperlipidemia, we compared their mean platelet volumes. We then …
Anticyclic Citrullinated Peptide Antibody In Rheumatoid Arthritis:A Cross-Sectional Study In Iran, Irandokht Shenavar Masooleh, Asghar Hajiabbasi, Habib Zayeni, Atefeh Ghanbari, Violet Zaker Esteghamati, Banafsheh Ghavidel Parsa, Amir Hassankhani
Anticyclic Citrullinated Peptide Antibody In Rheumatoid Arthritis:A Cross-Sectional Study In Iran, Irandokht Shenavar Masooleh, Asghar Hajiabbasi, Habib Zayeni, Atefeh Ghanbari, Violet Zaker Esteghamati, Banafsheh Ghavidel Parsa, Amir Hassankhani
Turkish Journal of Medical Sciences
Background/aim: Studies have shown that anticyclic citrullinated peptide antibody (anti-CCP) titers can be useful in the diagnosis of rheumatoid arthritis (RA). We evaluate the association between anti-CCP antibody titers and the demographic, clinical, and laboratory characteristics of RA patients. Moreover, we explore whether there is any relation between joint destruction and demographic and clinical characteristics of RA patients. Materials and methods: One hundred and four RA patients with positive anti-CCP titers were compared to 104 RA patients with negative anti-CCP titers. The activity of RA was evaluated using the Disease Activity Score 28 (DAS28). Joint destruction was assessed in the …
The Incidence Of Pressure Ulcer In Patients On Mechanical Ventilation Andeffects Of Selected Risk Factors On Pressure Ulcer Development*, Özgül Karayurt, Özay Akyol, Necmi̇ye Kiliçaslan, Nuray Akgün, Ümran Sargin, Meli̇ke Kondakçi, Hanim Eki̇nci̇, Nesli̇han Sari
The Incidence Of Pressure Ulcer In Patients On Mechanical Ventilation Andeffects Of Selected Risk Factors On Pressure Ulcer Development*, Özgül Karayurt, Özay Akyol, Necmi̇ye Kiliçaslan, Nuray Akgün, Ümran Sargin, Meli̇ke Kondakçi, Hanim Eki̇nci̇, Nesli̇han Sari
Turkish Journal of Medical Sciences
Background/aim: This study aimed to determine the incidence of pressure ulcers in patients on mechanical ventilation and selected risk factors likely to play a role in pressure ulcer development. Materials and methods: The study included 110 patients recruited from an anesthesia critical care unit of a university hospital. Data were collected with a demographic and clinical characteristics form. The form was composed of questions about demographic characteristics and clinical features including diagnosis, duration of mechanical ventilation, general well-being, oxygenation, perfusion, and skin condition. Results: The incidence of pressure ulcer was 15.5%. Duration of mechanical ventilation was longer and the body …
The Role Of Apelin In The Assessment Of Response To Chemotherapyand Prognosis In Stage 4 Nonsmall Cell Lung Cancer, Si̇nem Özsari, Gürsel Çok, Ali̇ Veral, Ti̇mur Köse
The Role Of Apelin In The Assessment Of Response To Chemotherapyand Prognosis In Stage 4 Nonsmall Cell Lung Cancer, Si̇nem Özsari, Gürsel Çok, Ali̇ Veral, Ti̇mur Köse
Turkish Journal of Medical Sciences
Background/aim: Prediction of response to chemotherapy and prognosis bears clinical significance in patients with lung cancer. The aim of the study was to examine the association between apelin expression in tumor tissues and overall survival, progression-free survival, chemoresistance, and treatment response in stage 4 nonsmall cell lung cancer (NSCLC) patients undergoing chemotherapy. Materials and methods: A total of 81 patients who received chemotherapy due to a biopsy-documented diagnosis of NSCLC between 2004 and 2011 were retrospectively studied. Bronchoscopic biopsy samples were examined immunohistochemically. Results: Of the overall study population (n = 81), the mean age was 59.0 ± 9.2 years; …
Differentiated Thyroid Cancer In Patients With Prolactinoma, Abbas Ali̇ Tam, Cafer Kaya, Cevdet Aydin, Reyhan Ersoy, Beki̇r Çakir
Differentiated Thyroid Cancer In Patients With Prolactinoma, Abbas Ali̇ Tam, Cafer Kaya, Cevdet Aydin, Reyhan Ersoy, Beki̇r Çakir
Turkish Journal of Medical Sciences
Background/aim: Increasing evidence is available about the role of prolactin in the development of various cancers. The purpose of this study is to evaluate the frequency of thyroid cancer in patients with prolactinoma followed at a single site. Materials and methods: The medical records of 182 patients diagnosed with prolactinoma were reviewed retrospectively. Serum prolactin, antithyroglobulin, antithyroid peroxidase antibody, thyroid-stimulating hormone, free T4, and free T3 values and pituitary gland magnetic resonance imaging and thyroid ultrasound reports were evaluated. Results: Forty-five (39.5%) patients were found to have a thyroid nodule (13 solitary, 32 multiple). Ten patients were administered a thyroidectomy, …
Cost Analysis And Evaluation Of Nosocomial Infections In Intensive Care Units, Uğur Kostakoğlu, Sedat Saylan, Mevlüt Karataş, Serap İskender, Fi̇rdevs Aksoy, Gürdal Yilmaz
Cost Analysis And Evaluation Of Nosocomial Infections In Intensive Care Units, Uğur Kostakoğlu, Sedat Saylan, Mevlüt Karataş, Serap İskender, Fi̇rdevs Aksoy, Gürdal Yilmaz
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to evaluate nosocomial infections occurring in our hospital intensive care units (ICUs) and the risk factors for these, and to determine the effect of these infections on mortality and cost. Materials and methods: This retrospective study was performed via infection control committee surveillance data, ICU records, and information processing data between 1 January and 31 December 2013 at the Kanuni Education and Research Hospital. Results: A total of 309 nosocomial infections were observed in 205 out of 566 patients. The density of nosocomial infections was 25.4 in 1000 patient days. Hospitalization was prolonged, …
Examination Of Factors Affecting Women?S Barrier Perception To Participate In Breast Cancer Screenings In A Region Affiliated With A Family Health Center In Turkey, Fatma Ersi̇n, Peri̇han Polat
Examination Of Factors Affecting Women?S Barrier Perception To Participate In Breast Cancer Screenings In A Region Affiliated With A Family Health Center In Turkey, Fatma Ersi̇n, Peri̇han Polat
Turkish Journal of Medical Sciences
Background/aim: This study was conducted in order to determine the factors related to women's barrier perception to participate in breast cancer screenings in a region affiliated with a family health center. Materials and methods: The study was a cross-sectional study. The sample group of the study consisted of 300 women. Descriptive statistics, t test, and Mann-Whitney U test were performed for the analysis of the data. Results: Breast self-examination (BSE) and mammography barrier perception mean score of those who were illiterate in terms of educational status, and BSE and mammography barrier perception mean score of those who were single in …
Efficacy Of Mitomycin-C And Infliximab In Reducing Adhesionand Fibrosis Following Strabismus Surgery*, Emi̇n Serbülent Güçlü, Ayşe Ayça Sari, Erdem Di̇nç, Tuba Özcan Meti̇n, Banu Coşkun Yilmaz, Bahar Taşdelen
Efficacy Of Mitomycin-C And Infliximab In Reducing Adhesionand Fibrosis Following Strabismus Surgery*, Emi̇n Serbülent Güçlü, Ayşe Ayça Sari, Erdem Di̇nç, Tuba Özcan Meti̇n, Banu Coşkun Yilmaz, Bahar Taşdelen
Turkish Journal of Medical Sciences
Background/aim: The present study aimed to investigate the efficacy of mitomycin-C (MMC) and infliximab (INF) in reducing adhesion and fibrosis following strabismus surgery. Materials and methods: Forty eyes of 20 albino rabbits were separated into MMC and INF groups. Right and left eyes of rabbits were assigned to the drug and control groups, respectively. The superior rectus muscle was disinserted, the drug was administered to the surgical area for 5 min in the drug eyes (MMC 0.2 mg/mL or INF 5 mg/mL), and physiological saline was administered to the control eyes. Surgical areas were rinsed with 10 mL of physiological …
The Common Genetic Variants Of Toll-Like Receptor And Susceptibilityto Adenoid Hypertrophy: A Hospital-Based Cohort Study, Mehmet Ali̇ Babademez, Tali̇h Özdaş, Si̇bel Özdaş
The Common Genetic Variants Of Toll-Like Receptor And Susceptibilityto Adenoid Hypertrophy: A Hospital-Based Cohort Study, Mehmet Ali̇ Babademez, Tali̇h Özdaş, Si̇bel Özdaş
Turkish Journal of Medical Sciences
Background/aim: Adenoid hypertrophy (AH) is one of the most frequent pediatric disorders. The aim of this study was to investigate the effects of TLR2-R753Q, TLR4-T399I, and TLR4-D299G polymorphisms in children with AH. Materials and methods: The variants of the TLR gene were determined by restriction fragment length polymorphism (PCR-RFLP) analysis in 60 patients with AH and in 50 healthy children. Data were analyzed with SNPStats and multifactor dimensionality reduction (MDR) software. Results: We found that the presence of the G allele, the AG+GG and AG genotypes at TLR4-D299G, and the GGT haplotype were associated with AH in children (P = …
Neurological Outcome After Cardiac Arrest: A Prospective Study Of The Predictive Ability Of Prognostic Biomarkers Neuron-Specific Enolase, Glial Fibrillary Acidic Protein, S-100b, And Procalcitonin, Gülay Ok, Demet Aydin, Koray Erbüyün, Canan Gürsoy, Fatma Taneli̇, Sema Bi̇lge, Gönül Di̇nç Horasan
Neurological Outcome After Cardiac Arrest: A Prospective Study Of The Predictive Ability Of Prognostic Biomarkers Neuron-Specific Enolase, Glial Fibrillary Acidic Protein, S-100b, And Procalcitonin, Gülay Ok, Demet Aydin, Koray Erbüyün, Canan Gürsoy, Fatma Taneli̇, Sema Bi̇lge, Gönül Di̇nç Horasan
Turkish Journal of Medical Sciences
Background/aim: Factors affecting neurological outcome and the usefulness of neuron-specific enolase (NSE), S-100B, glial fibrillary acidic protein (GFAP), and procalcitonin (PCT) in predicting neurological outcomes were assessed in patients who survived at least 24 h after cardiopulmonary resuscitation (CPR). Materials and methods: Thirty successfully resuscitated cardiac arrest patients were included in this prospective clinical study. The initial cardiac arrest rhythm, duration of CPR, return of spontaneous circulation time, administered doses of adrenaline, base excess, blood sugar, and hemodynamic parameters were recorded. Patients with Glasgow Outcome Scale (GOS) scores of 1-3 were defined as Group I and patients with GOS scores …
Evaluation Of Cutaneous Anthrax Cases During An Outbreak In The East Region Of Turkey, Esra Kural Ünüvar, Deni̇z Bahar Akgün Karapinar, Nazli Di̇zen Namdar
Evaluation Of Cutaneous Anthrax Cases During An Outbreak In The East Region Of Turkey, Esra Kural Ünüvar, Deni̇z Bahar Akgün Karapinar, Nazli Di̇zen Namdar
Turkish Journal of Medical Sciences
Background/aim: Anthrax is a zoonotic infection caused by Bacillus anthracis. We aimed to retrospectively evaluate cutaneous anthrax cases that occurred during an outbreak in eastern Turkey (Hakkari-Yüksekova), where people mostly earn their living from animal husbandry. Materials and methods: Forty-six cutaneous anthrax patients that were admitted to the hospital during a very short duration of 3 months (June-August 2011) were evaluated. Results: Out of 46 patients, 27 (52%) were women and 19 (48%) were men. The mean age was 37 ± 13 years. The distribution of occupations was 1 butcher, 1 cook, 5 farmers, 27 housewives, 11 shepherds, and 1 …
Health-Related Quality Of Life Of Pediatric Renal Transplant Recipientsand Their Parents: The Role Of Associated Factors And Clinical Counseling, Bahar Büyükkaragöz, Necla Buyan, Nahi̇de Doğrucan, Bülent Çeli̇k
Health-Related Quality Of Life Of Pediatric Renal Transplant Recipientsand Their Parents: The Role Of Associated Factors And Clinical Counseling, Bahar Büyükkaragöz, Necla Buyan, Nahi̇de Doğrucan, Bülent Çeli̇k
Turkish Journal of Medical Sciences
Background/aim: This study evaluates the health-related quality of life (HRQoL) of pediatric renal transplant recipients and their parents and investigates the effects of clinical, socioeconomic, and psychological factors as well as continuous counseling on the HRQoL. Materials and methods: Patients aged 8-17 years (mean: 14.9 ± 2.9) were enrolled. Clinical and demographic data were noted. The Beck Depression Inventory (BDI), Rosenberg Self-Esteem Scale (RSES), and Turkish version of the Kinder Lebensqualität Fragebogen (KINDL) questionnaire for children and the BDI, RSES, parent-proxy version of KINDL, and Short-Form 36 (SF-36) for parents were applied (step 1). Following a 1-year counseling program, the …
The Effect Of Cotinine Concentrations In Seminal Plasma And Follicular Fluid On The Pregnancy Outcomes Of Couples Undergoing Assisted Reproductive Techniques, Füsun Terzi̇oğlu, Bensu Karahali̇l, Çi̇ğdem Yücel, Ruki̇ye Türk
The Effect Of Cotinine Concentrations In Seminal Plasma And Follicular Fluid On The Pregnancy Outcomes Of Couples Undergoing Assisted Reproductive Techniques, Füsun Terzi̇oğlu, Bensu Karahali̇l, Çi̇ğdem Yücel, Ruki̇ye Türk
Turkish Journal of Medical Sciences
Background/aim: This study determined the effects of cotinine concentrations in follicular fluid (FF) and seminal plasma (SP) on the pregnancy outcome of couples using assisted reproductive techniques (ARTs). Materials and methods: This study was conducted as a case-control study. A total of 217 couples were included in the study. Among these couples, there were nonsmokers (66 women and 40 men), passive smokers (106 women and 54 men), and active smokers (45 women and 123 men). Demographic and smoking data were collected by questionnaire at the onset of treatment. FF and SP samples were obtained from the couples on the day …
The Effect Of Pneumoperitoneum On Intravascular Fibrinolytic Activity In Rats, Kürşat Di̇kmen, Asi̇ye Uğraş Di̇kmen, Hasan Bostanci, Ahmet Karamercan, Abdullah Münci̇ Yağci, Murat Akin, Bülent Aytaç
The Effect Of Pneumoperitoneum On Intravascular Fibrinolytic Activity In Rats, Kürşat Di̇kmen, Asi̇ye Uğraş Di̇kmen, Hasan Bostanci, Ahmet Karamercan, Abdullah Münci̇ Yağci, Murat Akin, Bülent Aytaç
Turkish Journal of Medical Sciences
Background/aim: Venous stasis during pneumoperitoneum in laparoscopic surgery is closely related to fibrin synthesis and deposition. The etiologic factors underlying fibrinolysis or hypercoagulability are not clearly defined. This study aimed to determine the effects of pneumoperitoneum time and pressure on coagulation cascade and the fibrinolytic pathway. Materials and methods: After the pneumoperitoneum model was established in rats, PAI-1, tPA, TAFI, D-dimer, and fibrinogen activities were evaluated in different time periods under different pressures in groups including 6 rats. Group 1 did not undergo any procedure. Group 2 received 8 mmHg of pressure for 30 min, Group III 8 mmHg for …
Adulthood Behavioral And Neurodevelopmental Effects Of Being Raised Byan Ambivalent Mother In Rats: What Does Not Kill You Makes You Stronger, Refi̇a Aslihan Dönmez, Selçuk Candansayar, Okşan Deri̇nöz, Özlem Gülbahar, Hayrunni̇sa Bolay
Adulthood Behavioral And Neurodevelopmental Effects Of Being Raised Byan Ambivalent Mother In Rats: What Does Not Kill You Makes You Stronger, Refi̇a Aslihan Dönmez, Selçuk Candansayar, Okşan Deri̇nöz, Özlem Gülbahar, Hayrunni̇sa Bolay
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the effects of early adverse life events and being raised by an ambivalent mother on rats. Materials and methods: The rats were separated into four groups: 1) the control group (n = 12), which was raised under standard care; 2) the early handling (EH) group, which was raised using an EH model (n = 16); 3) the early deprivation (ED) group, which was raised using an ED model (n = 13), and 4) the ambivalent mother (AM) group, which spent 3 h/day with a "fake mother" (n = 17). When they became adults, their …
Effect Of Resveratrol On Resistin And Apelin Gene Expressions In Adipose Tissue Of Diabetic Rats, Sadegh Zarei, Massoud Saidijam, Jamshid Karimi, Reza Yadegarazari, Azam Rezaei Farimani, Solmazsaadat Hosseini-Zijood, Mohammad Taghi Goodarzi
Effect Of Resveratrol On Resistin And Apelin Gene Expressions In Adipose Tissue Of Diabetic Rats, Sadegh Zarei, Massoud Saidijam, Jamshid Karimi, Reza Yadegarazari, Azam Rezaei Farimani, Solmazsaadat Hosseini-Zijood, Mohammad Taghi Goodarzi
Turkish Journal of Medical Sciences
Background/aim: Adipose tissue plays a major role in glucose homeostasis. Dietary antioxidants such as resveratrol (RSV) may offer some protection against the early stage of diabetes mellitus and the development of complications. The present study investigated the effects of RSV on biochemical parameters and resistin and apelin gene expressions in adipose tissue of rats with type 2 diabetes. Materials and methods: Diabetes was induced using a single dose of streptozotocin + nicotinamide. Three groups of diabetic rats were treated with different doses of RSV (1, 5, and 10 mg/kg body weight per day). Oxidative status, serum biochemical parameters, insulin, and …
Therapeutic Effects Of Intralipid And Medialipid Emulsionsin A Rat Model Of Verapamil Toxicity, Fatma Akgün Şahi̇n, Sidika Hülya Çelebi̇, İrfan Güngör, Demet Coskun, Eli̇f Ergüven Kaya
Therapeutic Effects Of Intralipid And Medialipid Emulsionsin A Rat Model Of Verapamil Toxicity, Fatma Akgün Şahi̇n, Sidika Hülya Çelebi̇, İrfan Güngör, Demet Coskun, Eli̇f Ergüven Kaya
Turkish Journal of Medical Sciences
Background/aim: Lipid emulsions are promising as a potential new therapy for severe verapamil overdose. Our purpose is to draw attention to the choice of solution by investigating the efficacy of intralipid 20% or medialipid 20% in verapamil overdose. Materials and methods: Eighteen adult Sprague Dawley rats were randomly divided into three groups: control (saline; Group C), intralipid 20% (Group I), and medialipid 20% (Group M). Rats were anesthetized with ketamine. Blood gas analysis, baseline heart rate (HRb), and mean arterial pressure (MAPb) were evaluated. Verapamil at 2.5 mg kg-1 min-1 was infused until the HRb and MAPb decreased by 50% …
Boswellia Serrata Gum Resin Aqueous Extract Upregulatesbdnf But Not Creb Expression In Adult Male Rat Hippocampus, Mohammad Khalaj-Kondori, Farzaneh Sadeghi, Mohammad Ali Hosseinpourfeizi, Farzam Shaikhzadeh-Hesari, Aylar Nakhlband, Mohammad Rahmati-Yamchi
Boswellia Serrata Gum Resin Aqueous Extract Upregulatesbdnf But Not Creb Expression In Adult Male Rat Hippocampus, Mohammad Khalaj-Kondori, Farzaneh Sadeghi, Mohammad Ali Hosseinpourfeizi, Farzam Shaikhzadeh-Hesari, Aylar Nakhlband, Mohammad Rahmati-Yamchi
Turkish Journal of Medical Sciences
Background/aim: Boswellia from the family Burseraceae has been proposed for prevention of amnesia; however, the molecular mechanism by which it affects memory is not clear. To reveal the potential molecular mechanism, the effects of boswellia on the expression of two memory related genes, CREB and BDNF, were investigated. Materials and methods: Twenty-one male rats were randomly divided into 3 groups (n = 7): the control group received distilled water and the treatment groups received two doses of aqueous extract of Boswellia serrata gum resin (boswellia) (50 and 100 mg/kg) every day for 4 weeks. The animals were tested by the …
Effects Of Crocin On Experimental Obesity And Type-2 Diabetes, Ömer Hazman, Laçi̇ne Aksoy, Ahmet Büyükben
Effects Of Crocin On Experimental Obesity And Type-2 Diabetes, Ömer Hazman, Laçi̇ne Aksoy, Ahmet Büyükben
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to scrutinize the effects of crocin on obesity and type-2 diabetes, with an approach that takes oxidative stress and inflammatory parameters into account. Materials and methods: The experimental obesity model was created by utilizing a 10-week-long high-fat diet (HFD). An experimental type-2 diabetes model was created by injecting multiple low-dose streptozocin (STZ) injections into rats that were fed with the HFD. The treatment groups were administered a daily crocin dose of 150 mg/kg for 6 weeks via gavage. Results: Findings of the study demonstrated that crocin could be effective in relieving the symptoms …
Rigorous Evaluation Of The Patterns Of Nickel Sensitization Inchildren With Atopic Dermatitis Is Needed, Nikoleta Brankov, Sharon E. Jacob
Rigorous Evaluation Of The Patterns Of Nickel Sensitization Inchildren With Atopic Dermatitis Is Needed, Nikoleta Brankov, Sharon E. Jacob
Turkish Journal of Medical Sciences
No abstract provided.
Isolation Of Virulent Rhodococcus Equi From Arabian Horses In Şanlıurfa, Turkey, Osman Yaşar Tel, Oktay Keski̇n, Sevi̇l Erdenli̇ğ Gürbi̇lek
Isolation Of Virulent Rhodococcus Equi From Arabian Horses In Şanlıurfa, Turkey, Osman Yaşar Tel, Oktay Keski̇n, Sevi̇l Erdenli̇ğ Gürbi̇lek
Turkish Journal of Veterinary & Animal Sciences
The purposes of this study were to investigate plasmid profiles of the isolated virulent (VapA positive) agents by RFLP and to determine the quantitative aspects of Rhodococcus equi in the feces of adult horses and foals, as well as in soil. The frequency of detection of R. equi and virulent R. equi in fecal samples and soil was studied from 20 farms in the Şanlıurfa region. A total of 315 samples were examined. Nasal swabs from 25 foals with pneumonia were also analyzed. R. equi was isolated and identified from 263 (83.4%) samples originating from 15 out of 20 farms. …
Effect Of Different Extenders On Motility And Some Sperm Kinematics Parameters In Norduz Goat Semen, Koray Teki̇n, Ali̇ Daşkin
Effect Of Different Extenders On Motility And Some Sperm Kinematics Parameters In Norduz Goat Semen, Koray Teki̇n, Ali̇ Daşkin
Turkish Journal of Veterinary & Animal Sciences
Use of computer-assisted sperm analyzers (CASAs) to evaluate sperm fertilizing ability has great importance for the artificial insemination industry. For motility evaluation, different CASA systems and diluents are being used. These assays are poor in predicting sperm fertility, because only the samples with markedly poor quality can be detected. However, there is not a unitary extender worldwide. Therefore, we aimed to evaluate the postthaw kinetic parameters of curvilinear velocity (VCL), straight-line velocity (VSL), and average-path velocity (VAP) with two different extenders (skim milk, SM; Tris, TS). Semen was collected twice a week with an artificial vagina from four adult Norduz …
The Role Of Porcine Reproductive And Respiratory Syndrome Virus As A Risk Factor In The Outbreak Of Porcine Epidemic Diarrhea In Immunized Swine Herds, Mei-Zhou Huang, Hui Wang, Sheng-Yi Wang, Dong-An Cui, Xin Tuo, Yong-Ming Liu
The Role Of Porcine Reproductive And Respiratory Syndrome Virus As A Risk Factor In The Outbreak Of Porcine Epidemic Diarrhea In Immunized Swine Herds, Mei-Zhou Huang, Hui Wang, Sheng-Yi Wang, Dong-An Cui, Xin Tuo, Yong-Ming Liu
Turkish Journal of Veterinary & Animal Sciences
The aim of the study was to investigate the relation between porcine epidemic diarrhea (PED) and porcine reproductive and respiratory syndrome virus (PRRSV). Here, we constructed a dynamic clinical experimental model in which sows were infected with PRRSV. The stability of the experimental model was surveyed by detecting the levels of antibodies against classical swine fever virus (CSFV) or PRRSV, respectively. In both group A (infected group) and group B (healthy group), the CSFV antibody level was not significantly different (P > 0.05). In group B, the PRRSV antibody level was also not significantly different (P > 0.05) at the three times …