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Articles 2881 - 2910 of 8080
Full-Text Articles in Medicine and Health Sciences
Decreased Oxidative Stress May Contribute To The Disease Process In Placenta Accreta, Efser Öztaş, Si̇bel Özler, Merve Ergi̇n, Özcan Erel, Başak Güler, Ali̇ Turhan Çağlar, Aykan Yücel, Di̇lek Uygur, Ahmet Nuri̇ Danişman
Decreased Oxidative Stress May Contribute To The Disease Process In Placenta Accreta, Efser Öztaş, Si̇bel Özler, Merve Ergi̇n, Özcan Erel, Başak Güler, Ali̇ Turhan Çağlar, Aykan Yücel, Di̇lek Uygur, Ahmet Nuri̇ Danişman
Turkish Journal of Medical Sciences
Background/aim: The main aim of this study was to investigate serum total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and arylesterase levels in pregnant women with placenta accreta and to compare those with age-matched healthy pregnant women. Materials and methods: A total of 27 pregnant women who had clinically and pathologically proven placenta accreta and 30 age- and BMI- matched healthy pregnant women were enrolled in this case control study. Maternal serum TOS, TAS, OSI, and arylesterase levels were evaluated using logistic regression analysis to determine if there was an association with abnormal placental invasion or …
Comparison Of Microscopy, Elisa, And Real-Time Pcr For Detectionof Giardia Intestinalis In Human Stool Specimens, Yunus Emre Beyhan, Zeynep Taş Cengi̇z
Comparison Of Microscopy, Elisa, And Real-Time Pcr For Detectionof Giardia Intestinalis In Human Stool Specimens, Yunus Emre Beyhan, Zeynep Taş Cengi̇z
Turkish Journal of Medical Sciences
Background/aim: This study included patients who had digestive system complaints between August 2015 and October 2015. The research was designed to compare conventional microscopy with an antigen detection ELISA kit and the TaqMan-based real-time PCR (RT-PCR) technique for detection of Giardia intestinalis in human stool specimens. Materials and methods: Samples were concentrated by formalin-ether sedimentation technique and microscopic examinations were carried out on wet mount slides. A commercially available ELISA kit (Giardia CELISA, Cellabs, Brookvale, Australia) was used for immunoassay. DNA was extracted from fecal samples of about 200 mg using the QIAamp Fast DNA Stool Mini Kit (QIAGEN, Hilden, …
Chromosomal Findings And Sequence Analysis Of Target Exons Of Calcium-Sensingreceptor (Casr) Gene In Patients With Sagliker Syndrome, Erdal Tunç, Osman Demi̇rhan, Yahya Sağliker, İsmai̇l Yildiz, Nuray Paylar, Ali̇ İrfan Güzel
Chromosomal Findings And Sequence Analysis Of Target Exons Of Calcium-Sensingreceptor (Casr) Gene In Patients With Sagliker Syndrome, Erdal Tunç, Osman Demi̇rhan, Yahya Sağliker, İsmai̇l Yildiz, Nuray Paylar, Ali̇ İrfan Güzel
Turkish Journal of Medical Sciences
Background/aim: Sagliker syndrome (SS) develops as a continuation of chronic kidney disease and secondary hyperparathyroidism conditions. It was thought that there are some genetic predisposition factors leading to SS. The calcium-sensing receptor (CaSR) is essential for calcium homeostasis in the body. We aimed to examine SS patients for chromosome aberrations (CAs) and CaSR gene abnormalities in exons 2 and 3. Materials and methods: Twenty-three patients and 23 control subjects were admitted to Balcalı Hospital of the Medical Faculty of Çukurova University in Turkey between 2009 and 2011. Chromosomal analysis was performed according to standard cytogenetic methods. Full sequencing of exons …
Potential Drug-Drug Interactions Among Prescriptionsfor Elderly Patients In Primary Health Care, Zafer Gören, Mahluga J. Demirkapu, Gökçe Akpinar Acet, Sanda Çali, Medine Gülçebi̇ İdri̇z Oğlu
Potential Drug-Drug Interactions Among Prescriptionsfor Elderly Patients In Primary Health Care, Zafer Gören, Mahluga J. Demirkapu, Gökçe Akpinar Acet, Sanda Çali, Medine Gülçebi̇ İdri̇z Oğlu
Turkish Journal of Medical Sciences
Background/aim: Elderly patients are at high risk from drug-drug interactions (DDIs). This study evaluates the potential DDIs in Turkish elderly patients at a primary health care outpatient clinic. Materials and methods: Online database systems were used to examine DDIs on the prescriptions of patients (n = 1206). The clinical severity of DDIs was classified by the Lexi-Interact Online database. Results: Of the 5059 prescriptions, 33% were found to have DDIs. We detected 29 (0.9%) A, 380 (11.8%) B, 2494 (77.7%) C, 289 (9%) D, and 18 (0.6%) X risk rating category DDIs among the prescriptions. Prescriptions of female patients and …
Intravitreal Prn Ranibizumab Treatment For Macular Edemadue To Branch Retinal Vein Occlusion, Hasan Basri̇ Çakmak, Mücella Arikan Yorgun, Yasi̇n Toklu, Melek Mutlu
Intravitreal Prn Ranibizumab Treatment For Macular Edemadue To Branch Retinal Vein Occlusion, Hasan Basri̇ Çakmak, Mücella Arikan Yorgun, Yasi̇n Toklu, Melek Mutlu
Turkish Journal of Medical Sciences
Background/aim: To evaluate the effect of intravitreal pro re nata (PRN) ranibizumab treatment from the start on the best-corrected visual acuity (BCVA) and the central retinal thickness (CRT) in macular edema (ME) due to branch retinal vein occlusion (BRVO). Materials and methods: Patients with ME secondary to BRVO, who were treated on a PRN basis after a single intravitreal ranibizumab injection, were retrospectively evaluated. The main outcome measures were changes in BCVA and CRT as measured by optical coherence tomography. Results: The number of injections over 6 months was 2.43 ± 1.16. The mean BCVA of the patients was 0.84 …
Relation Of Unsupported And Unsupervised Exercise With Anthropometric And Biochemical Indices Among Type 2 Diabetic Patients, Prince Chikwere, Kwabena Nsiah, Marina Tandoh
Relation Of Unsupported And Unsupervised Exercise With Anthropometric And Biochemical Indices Among Type 2 Diabetic Patients, Prince Chikwere, Kwabena Nsiah, Marina Tandoh
Turkish Journal of Medical Sciences
Background/aim: Type 2 diabetes is a lifestyle-related condition. Lifestyle modification in the management of type 2 diabetes incorporates exercise. The aim of this study was to find out how unsupported and unsupervised exercise relates to anthropometric indices and biochemical indices in type 2 diabetes patients. Materials and methods: In the cross-sectional study, a structured questionnaire was used to access data on the exercise history of patients. Subjects were classified according to exercise intensity. The dietary intake of patients was obtained by 24-h recall. Standard measurements were taken of waist circumference and blood pressure. Blood samples were also collected to measure …
Abdominal Actinomycosis In The Last 10 Years And Risk Factors For Appendiceal Actinomycosis: Review Of The Literature, Marta Lisa-Gracia, Berta Martín-Rivas, Marcos Pajaron-Guerrero, Ana Arnaiz-García
Abdominal Actinomycosis In The Last 10 Years And Risk Factors For Appendiceal Actinomycosis: Review Of The Literature, Marta Lisa-Gracia, Berta Martín-Rivas, Marcos Pajaron-Guerrero, Ana Arnaiz-García
Turkish Journal of Medical Sciences
Background/aim: Actinomycosis is a granulomatous disease caused by filamentous, gram-positive, anaerobic bacteria. Actinomycetes are commensal inhabitants of the oral cavity and intestinal tract but acquire pathogenicity through invasion of breached or necrotic tissue. In abdominal actinomycosis (AA), the appendix and ileocecal region are usually involved. The aim of this study was to characterize patients diagnosed with AA and to establish the risk factors for appendiceal actinomycosis, including a short review of the literature. Materials and methods: We conducted a prospective cohort study of all patients diagnosed with AA in the University Hospital Marques de Valdecilla (Santander-Cantabria) from January 2003 to …
Endometriosis-Associated Changes In Serum Levels Of Interferons And Chemokines, Andrei Mihai Malutan, Tudor Drugan, Razvan Ciortea, Carmen Bucuri, Maria Patricia Rada, Dan Mihu
Endometriosis-Associated Changes In Serum Levels Of Interferons And Chemokines, Andrei Mihai Malutan, Tudor Drugan, Razvan Ciortea, Carmen Bucuri, Maria Patricia Rada, Dan Mihu
Turkish Journal of Medical Sciences
Background/aim: The aim of the study was to evaluate the serum concentration of main chemokines and interferons in patients with diagnosed endometriosis. Materials and methods: A total of 160 women were divided in two study groups (group 1 - endometriosis; group 2 - healthy women). Serum levels of IFN-α, IFN-γ, MCP-1, MIP-1α, MIP-1β, RANTES, eotaxin, IL-8, MIG, IP-10, and IL-17A were measured with Human Multiplex Cytokine Panels. Results. Serum levels of IFN-γ, MCP-1, and IL-8 were significantly higher (mean 14.03, 57.24, and 534.24, respectively, compared to 0.58, 20.51, and 259.82, respectively), and serum levels of IP-10 and eotaxin were significantly …
Qf-Pcr In Invasive Prenatal Diagnosis: A Single-Center Experience In Turkey, Özge Özer Kaya, Altuğ Koç, Taha Reşi̇d Özdemi̇r, Özgür Kirbiyik, Berk Özyilmaz, Mehmet Özeren, Deni̇z Can Özteki̇n, Cüneyt Eftal Taner, Yaşar Beki̇r Kutbay
Qf-Pcr In Invasive Prenatal Diagnosis: A Single-Center Experience In Turkey, Özge Özer Kaya, Altuğ Koç, Taha Reşi̇d Özdemi̇r, Özgür Kirbiyik, Berk Özyilmaz, Mehmet Özeren, Deni̇z Can Özteki̇n, Cüneyt Eftal Taner, Yaşar Beki̇r Kutbay
Turkish Journal of Medical Sciences
Background/aim: QF-PCR has been used for more than 20 years. It is based on investigation of polymorphic short tandem repeats (STRs) and is widely used for prenatal rapid aneuploidy detection. Materials and methods: We report retrospectively our prenatal diagnosis results between January 2012 and May 2014 in Tepecik Training and Research Hospital Genetic Diagnostic Center. Prenatal diagnosis was recommended in 6800 high-risk pregnancies and 2883 patients agreed to invasive diagnosis. Chromosome analysis and QF-PCR were performed in all patients. Results: Normal results were reported in 2711 cases by fetal karyotyping and in 2706 cases by QF-PCR. Anomaly detection rates were …
Comparison Of Response To Treatment Of Unilateral And Bilateral Varicocelectomy, Ercan Öğreden, Ural Oğuz, Abdullah Çirakoğlu, Erhan Demi̇relli̇, Erdal Benli̇, Orhan Yalçin
Comparison Of Response To Treatment Of Unilateral And Bilateral Varicocelectomy, Ercan Öğreden, Ural Oğuz, Abdullah Çirakoğlu, Erhan Demi̇relli̇, Erdal Benli̇, Orhan Yalçin
Turkish Journal of Medical Sciences
Background/aim: We aimed to compare the results of unilateral and bilateral varicocele surgery. Materials and methods: In two referral hospitals, the data of 180 patients who were treated with unilateral and bilateral microscopic varicocelectomy were retrospectively analyzed. Sperm parameters and spontaneous pregnancy rates were compared in patients who underwent bilateral and unilateral microscopic varicocelectomy. Results: The mean age was 29.6 (17-46) years. While 82 patients underwent unilateral varicocelectomy (Group I), 98 patients underwent bilaterally varicocelectomy (Group II). Forty (48.8%) spontaneous pregnancies occurred in Group I and 59 (60.2%) in Group II. When we analyzed sperm parameters, the rate of increase …
Retrospective Analysis Of Primary Gastric Diffuse Largeb-Cell Lymphoma: A Single Center Study From Turkey, Nur Soyer, Asu Fergün Yilmaz, Nazan Özsan, Fahri̇ Şahi̇n, Güray Saydam, Murat Tombuloğlu, Mi̇ne Heki̇mgi̇l, Fi̇li̇z Vural
Retrospective Analysis Of Primary Gastric Diffuse Largeb-Cell Lymphoma: A Single Center Study From Turkey, Nur Soyer, Asu Fergün Yilmaz, Nazan Özsan, Fahri̇ Şahi̇n, Güray Saydam, Murat Tombuloğlu, Mi̇ne Heki̇mgi̇l, Fi̇li̇z Vural
Turkish Journal of Medical Sciences
Background/aim: Diffuse large B-cell primary gastric lymphomas (DLBC-PGLs) are treated with different therapies. Their optimal treatment is not well documented. Materials and methods: We retrospectively analyzed the data of 51 patients diagnosed with DLBC-PGL in the previous 10 years. All patients were treated with R-CHOP as first line. Radiotherapy was added to chemotherapy in 8 patients. Surgery was performed in 5 patients. Results: The median follow-up time of the 51 patients was 45.5 (range 5-144) months and the complete response (CR) rate was 90.2%. CR was achieved in 34 (89.4%) of 38 patients treated with single chemotherapy, in all (100%) …
Evaluation Of Dental Technician's Pneumoconiosis Using Chest X-Rayand Hrct: Correlation Between Radiological And Functional Findings, Recai̇ Ergün, Di̇lek Ergün, Ender Evci̇k, Begüm Ergan
Evaluation Of Dental Technician's Pneumoconiosis Using Chest X-Rayand Hrct: Correlation Between Radiological And Functional Findings, Recai̇ Ergün, Di̇lek Ergün, Ender Evci̇k, Begüm Ergan
Turkish Journal of Medical Sciences
Background/aim: This study aimed to compare high-resolution computed tomography (HRCT) findings with those of chest X-ray (CXR) and to evaluate the relationship of pulmonary function test (PFT) parameters with HRCT and CXR findings in cases of dental technician's pneumoconiosis. Materials and methods: CXR, PFT, and HRCT data of 89 dental technicians who were diagnosed with pneumoconiosis were retrospectively evaluated. Results: The cases of 24 dental technicians (27%) classified as normal (Category 0) based on CXR were evaluated as Category 1 according to HRCT. There was an inverse correlation of PFT parameters with nodular profusion score in CXR and all HRCT …
Pentoxifylline Attenuates Mucosal Damage In An Experimental Model Of Rat Colitis By Modulating Tissue Biomarkers Of Inflammation, Oxidative Stress, And Fibrosis, Eylem Karatay, Özlem Gül Utku, Harun Erdal, Mehmet Arhan, İbrahi̇m Koral Önal, Mehmet İbi̇ş, Özgür Eki̇nci̇, Canan Yilmaz Demi̇rtaş, Gi̇yaseddi̇n Şükrü Dumlu
Pentoxifylline Attenuates Mucosal Damage In An Experimental Model Of Rat Colitis By Modulating Tissue Biomarkers Of Inflammation, Oxidative Stress, And Fibrosis, Eylem Karatay, Özlem Gül Utku, Harun Erdal, Mehmet Arhan, İbrahi̇m Koral Önal, Mehmet İbi̇ş, Özgür Eki̇nci̇, Canan Yilmaz Demi̇rtaş, Gi̇yaseddi̇n Şükrü Dumlu
Turkish Journal of Medical Sciences
Background/aim: This study was designed to identify the effect of pentoxifylline on trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. Materials and methods: Forty-two female Wistar rats were randomly divided into 7 groups: group A, TNBS + intraperitoneal (IP) pentoxifylline; group B, TNBS + IP saline; group C, TNBS + intrarectal (IR) pentoxifylline; group D, TNBS + IR saline; group E, IP pentoxifylline + TNBS; group F, IP saline + TNBS; group G, IR saline. Pentoxifylline was given daily for 3 days before or 6 days after the induction of colitis. Rats were killed after 6 days. Results: IP and IR …
Endosonogragphic Features Of Lesions Suggesting Gastricectopic Pancreas: Experience Of A Single Tertiary Center, Mahmut Yüksel, Sabi̇te Kacar, Muhammet Yener Akpinar, Fati̇h Saygili, Meral Akdoğan Kayhan, Selçuk Di̇şi̇beyaz, Yasemi̇n Özi̇n, Mustafa Kaplan, İhsan Ateş, Ertuğrul Kayaçeti̇n
Endosonogragphic Features Of Lesions Suggesting Gastricectopic Pancreas: Experience Of A Single Tertiary Center, Mahmut Yüksel, Sabi̇te Kacar, Muhammet Yener Akpinar, Fati̇h Saygili, Meral Akdoğan Kayhan, Selçuk Di̇şi̇beyaz, Yasemi̇n Özi̇n, Mustafa Kaplan, İhsan Ateş, Ertuğrul Kayaçeti̇n
Turkish Journal of Medical Sciences
Background/aim: We aimed to present the endoscopic ultrasound (EUS) features of gastric lesions suggesting gastric ectopic pancreas during upper gastrointestinal endoscopy that were diagnosed in our gastroenterology unit, which is a tertiary center for endoscopic procedures in Turkey. Materials and methods: The data of patients who underwent upper gastrointestinal EUS in our center between April 2012 and July 2014 were retrospectively analyzed. Results: All of the lesions suggesting gastric ectopic pancreas were localized in the gastric antrum. Thirty-six of 44 lesions (81.1%) showed central dimpling. Lesion borders were shown to be definite in 10 (22.7%) lesions, whereas the borders of …
Analysis Of Meiotic Spindle And Zona Pellucida Birefringenceof Ivm Oocytes In Pcos Patients, Fereshteh Safian, Mohammad Ali Khalili, Sareh Ashourzadeh, Marjan Omidi
Analysis Of Meiotic Spindle And Zona Pellucida Birefringenceof Ivm Oocytes In Pcos Patients, Fereshteh Safian, Mohammad Ali Khalili, Sareh Ashourzadeh, Marjan Omidi
Turkish Journal of Medical Sciences
Background/aim: Polycystic ovarian syndrome (PCOS) is one of the most common causes of infertility. One of the best therapeutic options for PCOS patients is intracytoplasmic sperm injection (ICSI). In vitro maturation (IVM) can also be a useful technique for these women. The goal of this study was to evaluate both the zona pellucida (ZP) birefringence and meiotic spindle (MS) of in vivo- and in vitro-matured oocytes from PCOS patients using the PolScope system. Materials and methods: Immature oocytes undergoing IVM and MII oocytes were obtained from PCOS patients in an ICSI program. Using PolScope, the presence of MS and ZP …
The Efficacy Of Narrowband Uvb Treatment In Pediatricvitiligo: A Retrospective Analysis Of 26 Cases, Serkan Yazi̇ci̇, Berri̇n Günay, Emel Bülbül Başkan, Kenan Aydoğan, Hayri̇ye Saricaoğlu, Şükran Tunali
The Efficacy Of Narrowband Uvb Treatment In Pediatricvitiligo: A Retrospective Analysis Of 26 Cases, Serkan Yazi̇ci̇, Berri̇n Günay, Emel Bülbül Başkan, Kenan Aydoğan, Hayri̇ye Saricaoğlu, Şükran Tunali
Turkish Journal of Medical Sciences
Background/aim: Narrowband UVB (Nb UVB) treatment is commonly used for the management of psoriasis and atopic dermatitis, and is less often used for vitiligo in children. The aim of this study was to evaluate the efficacy and short-term safety of Nb UVB phototherapy in children diagnosed with vitiligo retrospectively Materials and methods: A total of 26 patients younger than 18 years with the diagnosis of vitiligo and managed with Nb UVB phototherapy as documented in archive records were evaluated. Clinical response was assessed according to repigmentation of the lesions: good response when there was more than 75% repigmentation, moderate response …
Alpha-1 Antitrypsin Levels And Polymorphisms In Interstitial Lung Diseases, Nalan Demi̇r, Özlem Erçen Di̇ken, Hali̇l Gürhan Karabulut, Demet Karnak, Oya Kayacan
Alpha-1 Antitrypsin Levels And Polymorphisms In Interstitial Lung Diseases, Nalan Demi̇r, Özlem Erçen Di̇ken, Hali̇l Gürhan Karabulut, Demet Karnak, Oya Kayacan
Turkish Journal of Medical Sciences
Background/aim: Alpha-1 antitrypsin deficiency may be a potential predisposing factor for interstitial lung fibrosis. We investigated alpha-1 antitrypsin levels and its polymorphisms in patients with interstitial lung disease. Materials and methods: A total of 103 interstitial lung disease patients were compared. Results: The mean alpha-1 antitrypsin level in idiopathic interstitial pneumonia patients was 1.67 ± 0.33 g/L, and it was 1.54 ± 0.37 g/L in patients with nonidiopathic interstitial pneumonia (P = 0.13). Low alpha-1 antitrypsin levels were more frequently observed in nonidiopathic interstitial pneumonia patients compared with idiopathic interstitial pneumonia, but the difference was not statistically significant (8.9% vs. …
The Effect Of Transcatheter Aortic Valve Implantation On Mean Platelet Volume, Mehmet Burak Özen, Hüseyi̇n Ayhan, Haci Ahmet Kasapkara, Telat Keleş, Tahi̇r Durmaz, Kemal Eşref Erdoğan, Bi̇lge Duran Karaduman, Serdal Baştuğ, Cenk Sari, Abdullah Nabi̇ Aslan, Engi̇n Bozkurt
The Effect Of Transcatheter Aortic Valve Implantation On Mean Platelet Volume, Mehmet Burak Özen, Hüseyi̇n Ayhan, Haci Ahmet Kasapkara, Telat Keleş, Tahi̇r Durmaz, Kemal Eşref Erdoğan, Bi̇lge Duran Karaduman, Serdal Baştuğ, Cenk Sari, Abdullah Nabi̇ Aslan, Engi̇n Bozkurt
Turkish Journal of Medical Sciences
Background/aim: Transcatheter aortic valve implantation (TAVI) is an innovative approach to the treatment of aortic stenosis (AS) as an alternative to surgery in high-risk patients. Mean platelet volume (MPV) is considered an indicator of endothelial dysfunction, platelet function, and activation. In this study, we aimed to investigate MPV changes in patients undergoing TAVI. Materials and methods: This study included 100 patients diagnosed with symptomatic severe AS and treated with TAVI between July 2011 and August 2013. Hematological parameters of the patients were examined prior to the procedure and 24 h, 1 month, and 6 months after TAVI. Results: A statistically …
The Relationship Between Physical Fitness And Falling Risk And Fear Of Falling Incommunity-Dwelling Elderly People With Different Physical Activity Levels, Mehmet Duray, Arzu Genç
The Relationship Between Physical Fitness And Falling Risk And Fear Of Falling Incommunity-Dwelling Elderly People With Different Physical Activity Levels, Mehmet Duray, Arzu Genç
Turkish Journal of Medical Sciences
Background/aim: The aim of this research was to determine the effects of physical activity level (PAL) and physical fitness on falling parameters in community-dwelling elderly people. Materials and methods: Seventy-six elderly people were grouped as low PAL group (group 1, n: 38) and high PAL (group 2, n: 38) according to their PAL scores. PAL was measured by the Physical Activity Scale for the Elderly and muscle strength, muscle endurance, aerobic endurance, and flexibility tests were applied; body mass index (BMI) was calculated for physical fitness measurement. Fall assessment included falling risk (Berg Balance Scale), dynamic balance (Time Up and …
Association Of B7-H4 Gene Polymorphisms In Urothelial Bladder Cancer, Asuman Özgöz, Murat Şamli, Deni̇z Di̇nçel, Ahmet Şahi̇n, Ümi̇t İnce, Yeşi̇m Sağlican, Faruk Balci, Hale Şamli
Association Of B7-H4 Gene Polymorphisms In Urothelial Bladder Cancer, Asuman Özgöz, Murat Şamli, Deni̇z Di̇nçel, Ahmet Şahi̇n, Ümi̇t İnce, Yeşi̇m Sağlican, Faruk Balci, Hale Şamli
Turkish Journal of Medical Sciences
Background/aim: We aimed to study polymorphisms of the B7-H4 gene in order to evaluate a possible association in urothelial carcinoma, as it is highly expressed in cancer tissues. Materials and methods: In this study B7-H4 gene rs10754339, rs10801935, and rs3738414 SNPs were studied by PCR-RFLP method in paraffin-embedded tumor specimens from 62 urothelial carcinoma patients and in a control group including 30 patients without bladder cancer. Results: We detected that the rs10754339 polymorphism was more frequent in the cancer patients when compared with the control group (P < 0.05). Only the rs3738414 polymorphism showed a statistically significant difference in frequency between pathologic diagnostic groups. Conclusion: The rs10754339 AA genotype distribution was found to have a higher frequency whereas the rs3738414 AG genotype distribution was lower in the bladder cancer group (P < 0.05). None of the genotype distributions showed a significant difference from the control group for the rs10801935 polymorphism. We conclude that B7-H4 has the potential to be a useful prognostic marker in urothelial carcinoma.
Evaluation Of Serum Uric Acid Levels In Psoriasis Vulgaris, Emrah Yilmaz, Emi̇ne Tamer, Refi̇ka Ferda Artüz, Seray Külcü Çakmak, Fürüzan Köktürk
Evaluation Of Serum Uric Acid Levels In Psoriasis Vulgaris, Emrah Yilmaz, Emi̇ne Tamer, Refi̇ka Ferda Artüz, Seray Külcü Çakmak, Fürüzan Köktürk
Turkish Journal of Medical Sciences
Background/aim: Psoriasis has been accepted as a systemic disease and it is known to be associated with various disorders including metabolic syndrome. High serum uric acid levels are also associated with the components of metabolic syndrome. In this study, we aimed to determine serum uric acid levels in patients with psoriasis and the association of uric acid levels with disease activity by taking the presence of metabolic syndrome criteria into account, since it is one of the most important factors that affect serum uric acid levels. Materials and methods: In this cross-sectional study, we evaluated 70 psoriasis patients and 70 …
Xenobiotic/Drug Metabolizing Enzyme And Tp53 Polymorphisms And Clinical Outcomein Advanced Nonsmall Cell Lung Cancer Patients, Volkan Karacaoğlan, Ahmet Oğuz Ada, Serdar Bi̇lgen, Güzi̇de Tuğba Çeti̇nkaya, Emre Soydaş, Celaletti̇n Semi̇h Kunak, Si̇bel Meryem Alpar, Meral Gülhan, Mümtaz İşcan
Xenobiotic/Drug Metabolizing Enzyme And Tp53 Polymorphisms And Clinical Outcomein Advanced Nonsmall Cell Lung Cancer Patients, Volkan Karacaoğlan, Ahmet Oğuz Ada, Serdar Bi̇lgen, Güzi̇de Tuğba Çeti̇nkaya, Emre Soydaş, Celaletti̇n Semi̇h Kunak, Si̇bel Meryem Alpar, Meral Gülhan, Mümtaz İşcan
Turkish Journal of Medical Sciences
Background/aim: The association between polymorphisms of xenobiotic/drug metabolizing enzymes and TP53 and response to chemotherapy and survival of patients with nonsmall cell lung cancer (NSCLC) are limited and inconclusive. In this study, CYP2E1*5B, CYP2E1*6, CYP2E1*7B, GSTO1 (A140D), and TP53 (Arg72Pro) polymorphisms and response to platinum-based chemotherapy and survival in 137 advanced stage NSCLC patients were investigated. Materials and methods: Genetic polymorphism analyses were determined by polymerase chain reaction (PCR) coupled with restriction fragment length polymorphism (RFLP). Results: The patients with TP53 Pro/Pro variant were more likely to be resistant to chemotherapy than those with Arg/Arg variants with marginal significance (P …
A Study On The Validity And Reliability Of The Amblyopia Andstrabismus Questionnaire (A&Sq) In Turkish, Hali̇se Çoşkun, Sevi̇nç Taştan, Emi̇ne İyi̇gün, Fati̇h Mehmet Mutlu, Osman Meli̇h Ceylan, Hali̇l İbrahi̇m Altinsoy
A Study On The Validity And Reliability Of The Amblyopia Andstrabismus Questionnaire (A&Sq) In Turkish, Hali̇se Çoşkun, Sevi̇nç Taştan, Emi̇ne İyi̇gün, Fati̇h Mehmet Mutlu, Osman Meli̇h Ceylan, Hali̇l İbrahi̇m Altinsoy
Turkish Journal of Medical Sciences
Background/aim: This study aims to evaluate the reliability and validity of the Amblyopia and Strabismus Questionnaire (A&SQ) that is translated into Turkish. Materials and methods: This is a methodological study. A total of 149 patients took part in the survey research between December 2012 and June 2014 in an university hospital, and 37 were retested. Cronbach's alpha coefficient was used for the questionnaire's reliability analysis. Results: Cronbach's alpha coefficients for the subscales of fear of losing the better eye, distance estimation, visual disorientation, double vision, and social contact and appearance were found to be 0.80, 0.88, 0.95, 0.80, and 0.81, …
Allergic And Autoimmune Disorders In Families With Selective Iga Deficiency, Mustafa Erkoçoğlu, Ayşe Meti̇n, Ayşenur Kaya, Celal Özcan, Ayşegül Akan, Ersoy Ci̇velek, Murat Çapanoğlu, Tayfur Gi̇ni̇ş, Can Naci̇ Kocabaş
Allergic And Autoimmune Disorders In Families With Selective Iga Deficiency, Mustafa Erkoçoğlu, Ayşe Meti̇n, Ayşenur Kaya, Celal Özcan, Ayşegül Akan, Ersoy Ci̇velek, Murat Çapanoğlu, Tayfur Gi̇ni̇ş, Can Naci̇ Kocabaş
Turkish Journal of Medical Sciences
Background/aim: IgA deficiency is the most common human primary immunodeficiency. The prevalence of allergic disorders and autoimmunity is thought to be increased in selective IgA deficiency (sIgAD). However, it is currently unclear if these disorders coincide within these families. We aimed to evaluate the frequency of allergic and autoimmune disorders in children with sIgAD and their firstdegree relatives (FDRs). Materials and methods: The study included 81 children diagnosed with sIgAD and 274 of their FDRs. The presence of allergic and autoimmune disorders was evaluated and serum antithyroglobulin and antithyroid peroxidase levels were measured in both patients and their first-degree relatives. …
Association Of The Cetp Gene Taqib And D442g Polymorphisms With Essentialhypertension In The Chinese Mongolian Population, Shudong Niu, Xiaoming Tao, Jingping Li, Yongyue Liu, Jian Wang, Mingyu Cong, Keyong Zhang, Wenyu Zhou, Changchun Qiu
Association Of The Cetp Gene Taqib And D442g Polymorphisms With Essentialhypertension In The Chinese Mongolian Population, Shudong Niu, Xiaoming Tao, Jingping Li, Yongyue Liu, Jian Wang, Mingyu Cong, Keyong Zhang, Wenyu Zhou, Changchun Qiu
Turkish Journal of Medical Sciences
Background/aim: This study aimed to explore the associations of the cholesteryl ester transfer protein (CETP) gene TaqIB and D442G polymorphisms with essential hypertension (EH). Materials and methods: In this case-control study, 883 hypertensive patients and 1044 normal controls were randomly selected from the Mongolian population of China. Polymerase chain reaction (PCR) and direct sequencing of PCR products were used to identify the genotypes. Haplotype analysis was performed by estimating the haplotype frequencies using the online SHEsis package. Results: The distribution frequency of the B2-G haplotype was significantly lower in the EH group than in the control group (0.7% vs. 1.9%, …
Wheezing, Asthma, And Atopy In Premature Infants At 2 Years Of Age, Sevi̇m Ünal, Ayşenur Kaya, Leyla Bi̇lgi̇n, Emi̇ne Di̇bek Misirlioğlu, Can Naci̇ Kocabaş
Wheezing, Asthma, And Atopy In Premature Infants At 2 Years Of Age, Sevi̇m Ünal, Ayşenur Kaya, Leyla Bi̇lgi̇n, Emi̇ne Di̇bek Misirlioğlu, Can Naci̇ Kocabaş
Turkish Journal of Medical Sciences
Background/aim: We aimed to evaluate wheezing, bronchial asthma (BA), and atopy in premature infants at 2 years of age via a crosssectional study. Materials and methods: Premature infants at <37 weeks of gestational age (GA) were assessed for atopy by skin-prick test and serum immunoglobulin E level at 2 years of age. The family's and infant's histories of allergy, BA, atopy, and wheezing were obtained by questionnaire and from hospital records. Results: There were 98 infants, with mean birth weight (BW) 1517.4 ± 486.5 g and GA 30.8 ± 2.9 weeks. The frequencies of wheezing, asthma, and bronchopulmonary dysplasia (BPD) were 32.7%, 16.3%, and 14.3%, respectively. Skin-prick tests were positive for 11 subjects, with allergy to cereals for 7 infants, egg for 3, and peanut for 1. Wheezing was related to GA, BW, respiratory distress syndrome, mechanical ventilation, sepsis, asphyxia, smoking, antenatal steroid, BA, palivizumab prophylaxis, number of people in the household, and duration of hospitalization (P < 0.05). Wheezing was negatively correlated to GA. Family history of BA, smoking, and number of people in the household were linked to BA (P < 0.05). Conclusion: Wheezing was related to degree of premature birth, but BA was linked to BA in the family and smoking. Increased gestation should improve the infant's respiratory health up to 2 years of age.
Prediction Of Atopy Via Total Immunoglobulin E Levels Andskin Prick Tests In Patients With Psoriasis, Emi̇ne Sümeyye Ünal, Ülker Gül, Adi̇le Berna Dursun, Ferda Öner Erkekol
Prediction Of Atopy Via Total Immunoglobulin E Levels Andskin Prick Tests In Patients With Psoriasis, Emi̇ne Sümeyye Ünal, Ülker Gül, Adi̇le Berna Dursun, Ferda Öner Erkekol
Turkish Journal of Medical Sciences
Background/aim: Although the etiopathogeneses of psoriasis and atopy appear to be different, psoriasis has been found to be associated with atopy and atopic dermatitis. In this study, we aimed to determine the role of atopy by examining the medical history and clinical and laboratory findings of patients with psoriasis. Materials and methods: Patients with psoriasis, asthma patients, and healthy volunteers were included in the study. Serum total immunoglobulin E (IgE) levels were obtained, and prick tests were administered to all groups. Results: Psoriatic patients demonstrated percentages of atopy history (21.3%) that were higher than those of the healthy subjects (15.7%). …
Central Line-Associated Blood Stream Infections: Characteristics And Risk Factors Formortality Over A 5.5-Year Period, Aynur Ati̇lla, Zahi̇de Doğanay, Hale Kefeli̇ Çeli̇k, Mehmet Derya Demi̇rağ, Süleyman Sirri Kiliç
Central Line-Associated Blood Stream Infections: Characteristics And Risk Factors Formortality Over A 5.5-Year Period, Aynur Ati̇lla, Zahi̇de Doğanay, Hale Kefeli̇ Çeli̇k, Mehmet Derya Demi̇rağ, Süleyman Sirri Kiliç
Turkish Journal of Medical Sciences
Background/aim: Central line-associated bloodstream infections (CLABSIs) are associated with substantial morbidity and mortality and the infection rates vary in a wide range (high: 62.5%; low: 20%) in developing countries. We aimed to investigate the characteristics and the risk factors for mortality in patients with CLABSIs in intensive care units (ICUs) and provide the relevant data. Materials and methods: The electronic medical records database and file records obtained through active surveillance by an infection control committee of a hospital were screened to identify patients with CLABSIs hospitalized from January 2008 through July 2013. Results: A total of 166 CLABSI episodes in …
The Efficacy Of Microphototherapy With A Medlight Cupcubegrimed Device In Psoriatic Patients With Localized Lesions, Nesli̇han Yildirim, Gül Erki̇n
The Efficacy Of Microphototherapy With A Medlight Cupcubegrimed Device In Psoriatic Patients With Localized Lesions, Nesli̇han Yildirim, Gül Erki̇n
Turkish Journal of Medical Sciences
Background/aim: Psoriasis is a chronic skin disease. To reduce side effects associated with current treatment modalities, new treatment methods are required. Some clinicians have begun to use microphototherapy to treat psoriatic patients with a limited number of lesions (lesions affecting <10% of the body surface area). Materials and methods: Microphototherapy is indicated in patients whose lesions persist despite systemic and topical treatment or when such treatment is contraindicated. Our study aimed to evaluate the efficacy of microphototherapy in psoriasis patients with localized lesions. Patients in this unblinded and prospective study were treated three times a week for 50 sessions using a MedLight CupCUBE Grimed microphototherapy device that emits an ultraviolet B (UVB) spectrum. Results: Forty-five lesions in 23 psoriatic patients were treated. Treatment outcome was evaluated based on the Psoriasis Severity Index (PSI). PSI scores decreased significantly during the treatment. Conclusion: The MedLight CupCUBE Grimed microphototherapy device was effective for the treatment of psoriasis patients with localized lesions. The device can administer UVB radiation to involved regions while protecting uninvolved regions and minimizing radiation dose. However, having to be administered by experienced technicians and the long time required for each treatment session are disadvantages of the technique.
Effects Of Ankaferd Bloodstopper On Dermal Healing In Diabetic Rats, Sertaç Aktop, Burcu Çevreli̇, Deni̇z Genç, Emel Serdaroğlu Kaşikçi, Ni̇l Çomunoğlu Üstündağ, Noushi̇n Zi̇bandeh, Eli̇f Merve Özcan, Gökhan Göçmen, Mehmet Kami̇l Göker, İsmai̇l Tayfun Uzbay, Tunç Akkoç
Effects Of Ankaferd Bloodstopper On Dermal Healing In Diabetic Rats, Sertaç Aktop, Burcu Çevreli̇, Deni̇z Genç, Emel Serdaroğlu Kaşikçi, Ni̇l Çomunoğlu Üstündağ, Noushi̇n Zi̇bandeh, Eli̇f Merve Özcan, Gökhan Göçmen, Mehmet Kami̇l Göker, İsmai̇l Tayfun Uzbay, Tunç Akkoç
Turkish Journal of Medical Sciences
Background/aim: Diabetes mellitus inhibits wound-induced angiogenesis, impairs the wound healing process, and leads to the development of chronic wounds. Ankaferd BloodStopper (ABS) is a new and promising local haemostatic agent. Although the mechanism of ABS-mediated haemostasis is well established, little is known about the associated histological and biochemical tissue reactions. The aim of this study was to evaluate the effects of this new-generation local haemostatic agent on short-term soft-tissue healing in streptozotocin (STZ)-treated rats. Materials and methods: The 24 Wistar albino rats used in this study were divided into STZ-treated (STZ, n = 12) and nontreated groups (control, n = …