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Articles 2851 - 2880 of 8080
Full-Text Articles in Medicine and Health Sciences
Histopathological Effects Of Mesenchymal Stem Cells In Ratswith Bladder And Posterior Urethral Injuries, Berat Di̇lek Demi̇rel, Ünal Biçakci, Riza Rizalar, Ferda Alpaslan Pinarli, Oğuz Aydin
Histopathological Effects Of Mesenchymal Stem Cells In Ratswith Bladder And Posterior Urethral Injuries, Berat Di̇lek Demi̇rel, Ünal Biçakci, Riza Rizalar, Ferda Alpaslan Pinarli, Oğuz Aydin
Turkish Journal of Medical Sciences
Background/aim: To evaluate the effects of mesenchymal stem cell (MSC) therapy in an experimental bladder and posterior urethral injury model. Materials and methods: The study subjects consisted of 40 male Wistar albino rats that were divided into four groups: control group (n = 10) (the bladder was only surgically opened and closed), sham group (n = 10) (surgical procedure), IVMSC group (n= 10) (surgical procedure and intravenous MSC treatment), and LMSC group (n = 10) (surgical procedure and local MSC treatment). Histopathological evaluation was performed for the degree of fibrosis and inflammation and the extent and intensity of staining of …
Interleukin-6 And Hepcidin Expression Changes In Cardiac Tissue Of Long-Term Trained And Untrained Rats After Exhaustive Exercise, Badegül Sarikaya, Ali̇ Doğan Dursun, Elçi̇n Yağmur Taylan Deveden, Lamia Pinar
Interleukin-6 And Hepcidin Expression Changes In Cardiac Tissue Of Long-Term Trained And Untrained Rats After Exhaustive Exercise, Badegül Sarikaya, Ali̇ Doğan Dursun, Elçi̇n Yağmur Taylan Deveden, Lamia Pinar
Turkish Journal of Medical Sciences
Background/aim: Exercise benefits the cardiovascular system, but strenuous exercise can cause cardiac damage and induce cytokine production, particularly that of interleukin-6 (IL-6). Hepcidin, which is primarily regulated by IL-6, increases after exercise. Hepcidin is a possible protective factor against the adverse effects of strenuous exercise such as oxidative stress. The aim of the study is to reveal that training increases hepcidin and attenuates increased levels of IL-6 in the hearts of exhaustively exercised rats by comparing the IL-6 and hepcidin mRNA expression levels in trained and untrained groups.Materials and methods: Thirty male Wistar albino rats were assigned to the following …
Effects Of N-Acetylcysteine On Ovarian Tissue Autografted Intogranulation Tissue Compared To Back Muscle In Rats, Farideh Daneshpoya, Mojtaba Karimipour, Masoumeh Zirakjavanmard, Bagher Pourheydar
Effects Of N-Acetylcysteine On Ovarian Tissue Autografted Intogranulation Tissue Compared To Back Muscle In Rats, Farideh Daneshpoya, Mojtaba Karimipour, Masoumeh Zirakjavanmard, Bagher Pourheydar
Turkish Journal of Medical Sciences
Background/aim: Ovarian transplantation can preserve fertility in cancer patients. The aim of this study was to compare ovarian transplantation into granulation tissue (GT) versus back muscle (BM) sites and also to investigate the effects of N-acetylcysteine (NAC) as an antioxidant on ovarian survival in a rat autograft model.Materials and methods: Twenty-eight adult female rats were divided into four equal groups (n = 7 each) as follows: Group 1, ovarian tissue grafted into GT + saline (GT + saline); Group 2, ovarian tissue grafted into GT + NAC (GT + NAC); Group 3, ovarian tissue grafted into BM + saline (BM …
Empirical Therapy And Teicoplanin Use In Periprosthetic Joint Infections, Zeli̇ha Koçak Tufan, Hati̇ce Rahmet Güner, Gülruhsar Yilmaz, Aybegüm Özşahi̇n, Murat Bozkurt, Mehmet Akin Taşyaran
Empirical Therapy And Teicoplanin Use In Periprosthetic Joint Infections, Zeli̇ha Koçak Tufan, Hati̇ce Rahmet Güner, Gülruhsar Yilmaz, Aybegüm Özşahi̇n, Murat Bozkurt, Mehmet Akin Taşyaran
Turkish Journal of Medical Sciences
No abstract provided.
Analysis Of Fancc Gene Mutations (Ivs4+4a>T, Del322g, And R548x)In Patients With Fanconi Anemia In Pakistan, Iram Aftab, Saima Iram, Saba Khaliq, Muhammad Israr, Nadir Ali, Shah Jahan, Shabbir Hussain, Shagufta Khaliq, Shahida Mohsin
Analysis Of Fancc Gene Mutations (Ivs4+4a>T, Del322g, And R548x)In Patients With Fanconi Anemia In Pakistan, Iram Aftab, Saima Iram, Saba Khaliq, Muhammad Israr, Nadir Ali, Shah Jahan, Shabbir Hussain, Shagufta Khaliq, Shahida Mohsin
Turkish Journal of Medical Sciences
Background/aim: Fanconi anemia (FA) is an autosomal recessive disease determined by mutations in at least 16 genes, with distinct distributions in different populations. To the best of our knowledge, there are no reports regarding the molecular basis of the disease in FA patients in Pakistan. The current study aimed to determine the frequency of FANCC gene mutations, i.e. IVS4+4A>T, del322G, and R548X, in FA patients. Materials and methods: Genomic DNA was obtained from 36 FA patients. All samples were analyzed by polymerase chain reaction and restriction fragment length polymorphism techniques. Results: Mutation IVS4+4A>T was identified in 26 (72.2%) …
Effect Of Transfusion Of Washed Red Blood Cells On Serumpotassium Level In Hemodialysis Patients, Refi̇k Demi̇rtunç, Emel Üstün, Cumali̇ Karatoprak, Kadi̇r Kayataş, Fuat Çeti̇nkaya, Uğur Özensoy, Rümeyza Kazancioğlu
Effect Of Transfusion Of Washed Red Blood Cells On Serumpotassium Level In Hemodialysis Patients, Refi̇k Demi̇rtunç, Emel Üstün, Cumali̇ Karatoprak, Kadi̇r Kayataş, Fuat Çeti̇nkaya, Uğur Özensoy, Rümeyza Kazancioğlu
Turkish Journal of Medical Sciences
Background/aim: This study aimed to compare washed red blood cell (WRBC) transfusion versus nonwashed RBC (NWRBC) transfusion in terms of posttransfusion potassium levels in dialysis patients on a day when the patient did not receive dialysis. Materials and methods: The patients were randomly assigned into two groups, i.e. those receiving WRBCs (n = 21) and those receiving NWRBCs (n = 17). Both groups received one unit of RBCs. Serum potassium and sodium levels were measured before and at the 1st, 2nd, 3rd, 4th, and 6th hours after transfusion. Results: In the WRBC group, the changes in the serum potassium levels …
Radiation Therapy For Biliary Tract Tumors: The Joint Experience Of Three Centers, Mehmet Si̇nan Karabey, Eda Yi̇rmi̇beşoğlu Erkal, Ahmet Yolcu, Beki̇r Hakan Bakkal, Özlem Ay, Maksut Görkem Aksu, Emi̇ne Bi̇nnaz Sarper, Haldun Şükrü Erkal
Radiation Therapy For Biliary Tract Tumors: The Joint Experience Of Three Centers, Mehmet Si̇nan Karabey, Eda Yi̇rmi̇beşoğlu Erkal, Ahmet Yolcu, Beki̇r Hakan Bakkal, Özlem Ay, Maksut Görkem Aksu, Emi̇ne Bi̇nnaz Sarper, Haldun Şükrü Erkal
Turkish Journal of Medical Sciences
Background/aim: This study presents the joint experience of three centers in the treatment of patients with biliary tract tumors with radiation therapy (RT). Materials and methods: The records of 27 patients were retrospectively reviewed. All of the patients who had undergone surgical resection received postoperative adjuvant RT, whereas all of the patients who had not undergone a surgical resection received RT with palliative intent. Twenty patients with adequate performance status were treated with RT and chemotherapy, while the remaining seven patients were treated with RT alone. Results: Follow-up ranged from 1 to 44 months. Local control was not achieved in …
A Review Of Pediatric Pulmonary Hypertension With New Guidelines, Serdar Kula, Ayhan Pektaş
A Review Of Pediatric Pulmonary Hypertension With New Guidelines, Serdar Kula, Ayhan Pektaş
Turkish Journal of Medical Sciences
This study aims to review pediatric pulmonary hypertension (PH) by comparing the guidelines of the European Society of Cardiology (ESC)/European Respiratory Society (ERS), the American Heart Association (AHA)/American Thoracic Society (ATS), and the European Pediatric Pulmonary Vascular Disease Network (EPPVDN). All three sets of guidelines define PH as having a mean pulmonary artery pressure of ≥25 mmHg and accept the validity of the World Health Organization (WHO) classification system. Every child with a high index of suspicion for PH should undergo an initial work-up of chest X-rays, electrocardiography, and echocardiography. The AHA/ATS guidelines emphasize the necessity of cardiac catheterization and …
Profile Of Pot1 As Telomerase Shelterin Component Discriminatesbetween Cervical Cancer And Normal Cervical Cells, Andreas Budi Wijaya, Furqan Hidayatullah, Verina Veronica Setyabudhi, Faizal Reza Pahlevi, Rasyad Indra, Tatit Nurseta
Profile Of Pot1 As Telomerase Shelterin Component Discriminatesbetween Cervical Cancer And Normal Cervical Cells, Andreas Budi Wijaya, Furqan Hidayatullah, Verina Veronica Setyabudhi, Faizal Reza Pahlevi, Rasyad Indra, Tatit Nurseta
Turkish Journal of Medical Sciences
Background/aim: Telomerase activity is influenced by hTERT transcriptional regulation, shelterin, and posttranscriptional alternative splicing. Telomerase shelterin such as POT1 is highly correlated with various cancers. However, the profile of POT1 in cervical cancer has not been clearly identified. Therefore, it is important to identify its profile in cervical cancer biopsy tissue and normal cervical smears. Materials and methods: Biopsy tissue of cervical cancer patients and normal cervical smears were characterized using SDS-PAGE and western blot. Sixteen biopsy tissues of cervical cancer patients and 15 normal cervical smears were measured for POT1 level using ELISA. Results: The inline band at 70 …
Associations Between Obesity And The Radiographic Phenotype In Knee Osteoarthritis, Mehmet Derya Demi̇rağ, Seçi̇l Özkan, Şemi̇nur Haznedaroğlu, Evi̇n Aras Kilinç, Fatma Nur Baran Aksakal, Sefer Aycan, Berna Goker
Associations Between Obesity And The Radiographic Phenotype In Knee Osteoarthritis, Mehmet Derya Demi̇rağ, Seçi̇l Özkan, Şemi̇nur Haznedaroğlu, Evi̇n Aras Kilinç, Fatma Nur Baran Aksakal, Sefer Aycan, Berna Goker
Turkish Journal of Medical Sciences
Background/aim: Investigation of the association between obesity and the distinction of radiographic patterns in knee osteoarthritis. Materials and methods: Seven hundred and thirty-four women underwent weight-bearing antero-posterior knee radiography. Osteophytes and joint space narrowing (JSN) were graded according to the OARSI atlas. Each subject was assigned to one of the following groups with respect to the maximum score: osteophyte-dominant, indeterminate, JSN-dominant, and radiographically normal. Results: Obese patients had a significantly more frequent osteophyte-dominant pattern compared to nonobese subjects (74.5% and 38%, respectively, P < 0.001). Logistic regression analysis demonstrated that obesity had a stronger association with an osteophytedominant pattern compared to a JSN-dominant pattern (OR and 95% CI = 7.16 (3.15-16.26) and 1.63 (0.96-2.78), respectively). Age had a very weak effect on the distinction to an osteophyte-dominant pattern and no effect on JSN dominance (OR and 95% CI = 1.1 (1.06-1.15) and 1.02 (0.99-1.05), respectively). Conclusion: There might be an association between obesity and the radiographic phenotype in patients with knee osteoarthritis. The findings suggest that the association between obesity and the osteophyte formation is stronger than that of JSN.
Primary Sjögren's Syndrome In Patients With Celiac Disease, Funda Erbasan, Deni̇z Turgut Çoban, Uğur Karasu, Yeşi̇m Çeki̇n, Bayram Yeşi̇l, Ayhan Hi̇lmi̇ Çeki̇n, Di̇nç Süren, Mustafa Ender Terzi̇oğlu
Primary Sjögren's Syndrome In Patients With Celiac Disease, Funda Erbasan, Deni̇z Turgut Çoban, Uğur Karasu, Yeşi̇m Çeki̇n, Bayram Yeşi̇l, Ayhan Hi̇lmi̇ Çeki̇n, Di̇nç Süren, Mustafa Ender Terzi̇oğlu
Turkish Journal of Medical Sciences
Background/aim: Many autoimmune diseases occur concomitantly with celiac disease (CD). We aimed to determine the frequency of Sjögren's syndrome (SS) in CD patients based on SS-specific serology verified by minor labial salivary biopsy. Materials and methods: Eight-two patients with CD were included in the study. After examination for objective evidence of sicca complex, all patients were tested for serological presence of rheumatoid factor (RF) and antinuclear antibodies (ANAs) and for ANA profile. Minor labial salivary biopsy was performed for patients with positive serology and/or clinical signs of SS. Results: Of the patients included, 24 (29.3%) had dry eye symptoms while …
The Effects Of The Chloride:Sodium Ratio On Acid-Base Statusand Mortality In Septic Patients, Hakan Korkut Atalan, Bülent Güçyetmez
The Effects Of The Chloride:Sodium Ratio On Acid-Base Statusand Mortality In Septic Patients, Hakan Korkut Atalan, Bülent Güçyetmez
Turkish Journal of Medical Sciences
Background/aim: Calculation of the chloride:sodium (Cl-:Na+) ratio is proposed to enable a quick evaluation of the effect of Cl- and Na+ on the acid-base balance in critically ill patients. In the present study, the relationship of the Cl-:Na+ ratio of septic patients with acidbase status and ICU mortality were investigated. Materials and methods: In our two-center study, 434 patients who were diagnosed with sepsis were included. The patients were divided into three groups: low (<0.75), normal (≥0.75, <0.80), and high (≥0.80) Cl-:Na+ ratio groups. Patients' demographic data, blood gas values, length of ICU stay, and ICU mortality were recorded. Results: In the low and high groups, ICU mortality was significantly higher than in the normal group (29.3%, 37.1%) (P = 0.005). There was a negative correlation between the Cl:Na+ ratio and each of HCO3 -, standard base excess, and PaCO2 (r2 = 0.21, r2 = 0.19, and r2 = 0.17) (P < 0.001 for each). In the multivariate analysis, the ICU mortality was increased 2.6-fold (1.2-5.8) by low Cl-:Na+ ratio (P = 0.019). Conclusion: The Cl-:Na+ ratio is a useful parameter for showing the relationship between Cl- and Na+ and their impact on acid-base status. Low Cl-:Na+ ratio at ICU admission can be used as a prognostic indicator for increased ICU mortality in septic patients.
Attitudes, Wishes, And Needs Of Diabetes Patients And Their Relatives: Turkish Data Fromthe Dawn2 Study, İlhan Tarkun, Suzan Dumanli Özgöksu
Attitudes, Wishes, And Needs Of Diabetes Patients And Their Relatives: Turkish Data Fromthe Dawn2 Study, İlhan Tarkun, Suzan Dumanli Özgöksu
Turkish Journal of Medical Sciences
Background/aim: The DAWN2 (Diabetes Attitudes, Wishes, and Needs) study was conducted in order to ascertain the wishes, needs, and attitudes of diabetes patients, their relatives, and healthcare professionals. The study was conducted across 17 countries, including Turkey, and its objective was to introduce policies that could successfully meet these requirements. In this article, the needs, wishes, and attitudes of diabetes patients and their relatives in Turkey are compared with those from other countries. Materials and methods: Eighty patients with type 1 diabetes, 426 patients with type 2 diabetes, and 126 relatives of patients with diabetes were included in the study. …
Comparison Of The Standard Gnrh Antagonist Protocol And The Luteal Phase Estradiol/Gnrh Antagonist Priming Protocol In Poor Ovarian Responders, Mehmet Firat Mutlu, İlknur Mutlu, Mehmet Erdem, İsmai̇l Güler, Ahmet Erdem
Comparison Of The Standard Gnrh Antagonist Protocol And The Luteal Phase Estradiol/Gnrh Antagonist Priming Protocol In Poor Ovarian Responders, Mehmet Firat Mutlu, İlknur Mutlu, Mehmet Erdem, İsmai̇l Güler, Ahmet Erdem
Turkish Journal of Medical Sciences
Background/aim: The aim of the study was to compare the luteal estradiol patch/GnRH antagonists priming protocol (LPP) with the standard GnRH antagonist protocol in poor ovarian responders (PORs) in terms of the outcomes of in vitro fertilization (IVF) treatment Materials and methods: IVF outcomes of 265 cycles in 265 patients (106 in the LPP group, 159 in the standard GnRH antagonist group) were evaluated retrospectively. Results: Mean length of stimulation (11.4 ± 2.7 vs. 10.0 ± 2.7 days; P < 0.05) and the total gonadotropin dose (3403 ± 1060 vs. 2984 ± 1112) used were significantly greater in the LPP group than in the standard GnRH antagonist protocol group. The mean number of oocytes retrieved (3.5 ± 2.6 vs. 3.7 ± 2.8), the number of mature oocytes (2.8 ± 2.2 vs. 2.6 ± 2.2), fertilization rates (65% vs. 62%), the number of embryos transferred (1.6 ± 0.6 vs. 1.7 ± 0.6), and implantation rates (16% vs. 13%) were similar. The cancellation rate did not significantly differ between the groups (9.4% vs. 13.2%). There were no significant differences in the clinical pregnancy (11.3% vs. 13.2%) or live birth rates per patient (3.8% vs. 9.4%) and clinical pregnancy (18.8% vs. 22.6%) or live birth rates per embryo transfer (6.3% vs. 12.9%) between the groups. Conclusion: LPP does not improve IVF outcomes when compared with the standard GnRH antagonist protocol in PORs.
Predictors Of Health Related Quality Of Life In Childhood Epilepsy And Comparison Withhealthy Children: Findings From An Indian Study, Dipika Bansal, Chandrika Azad, Kapil Gudala, Anil Dasari
Predictors Of Health Related Quality Of Life In Childhood Epilepsy And Comparison Withhealthy Children: Findings From An Indian Study, Dipika Bansal, Chandrika Azad, Kapil Gudala, Anil Dasari
Turkish Journal of Medical Sciences
Background/aim: Children with epilepsy have reduced health-related quality of life (HRQOL) due to disease and medications. We aimed to assess child-reported HRQOL in Indian children with epilepsy and compare it with that in healthy children. Materials and methods: A cross-sectional study of 256 children with epilepsy aged between 5 and 18 years on antiepileptic drug (AED) treatment for at least 3 months was performed and 125 age and sex matched healthy children were included. A generic version of the Pediatric Quality of Life (PedsQL version 4) scale was used to assess HRQOL. Results: Children with epilepsy had diminished scores in …
An 8-Week Thoracic Spine Stabilization Exercise Program Improves Postural Back Pain,Spine Alignment, Postural Sway, And Core Endurance In University Students:A Randomized Controlled Study, Şeyda Toprak Çelenay, Derya Özer Kaya
An 8-Week Thoracic Spine Stabilization Exercise Program Improves Postural Back Pain,Spine Alignment, Postural Sway, And Core Endurance In University Students:A Randomized Controlled Study, Şeyda Toprak Çelenay, Derya Özer Kaya
Turkish Journal of Medical Sciences
Background/aim: To investigate the effects of an 8-week thoracic stabilization exercise program on back pain, spinal alignment, postural sway, and core endurance in university students. Materials and methods: University students were randomly allocated into exercise (n: 28) and control (n: 25) groups. The exercise program was carried out 3 days a week for 8 weeks. Postural pain, spinal alignment, postural sway, and core endurance were assessed via visual analogue scale, Spinal Mouse, Biodex Balance System, and McGill?s trunk muscle endurance tests at the baseline and after 8 weeks of training. Results: Differences were observed for postural pain, thoracic and lumbar …
Incidence Of Cancer In The Turkish Republic Of Northern Cyprus, Ruqiya Pervaiz, Pinar Tulay, Faisal Faisal, Nedime Serakinci
Incidence Of Cancer In The Turkish Republic Of Northern Cyprus, Ruqiya Pervaiz, Pinar Tulay, Faisal Faisal, Nedime Serakinci
Turkish Journal of Medical Sciences
ackground/aim: This study analyzed the incidence, trends, and common types of cancer in the Turkish Republic of Northern Cyprus (TRNC). Materials and methods: This study is based on data collected from the office of the North Cyprus Cancer Registry, Ministry of Health, for 2007-2012. Data were arranged on the basis of age group, sex, and cancer site. Age standardized incidence rates (ASRs) were estimated with the world standard population. EVIEWS (version 9) software was used for statistical analysis. Results: Of 1395 registered cases, 52.33% (730) were reported in men and 47.67% (665) in women. The crude incidence rate was 96.41 …
The Assessment Of Work Productivity And Activity Impairment In Behçet's Disease, Gonca Mumcu, Fadi̇me Lehi̇mci̇, Özlem Fi̇dan, Hülya Gük, Uğur Alpar, Ali̇ Uğur Ünal, Zeynep Ertürk, Fatma Ali̇baz Öner, Güzi̇de Nevsun İnanç, Safi̇ye Atlas Tüli̇n Ergun, Rafi̇ Haner Di̇reskeneli̇
The Assessment Of Work Productivity And Activity Impairment In Behçet's Disease, Gonca Mumcu, Fadi̇me Lehi̇mci̇, Özlem Fi̇dan, Hülya Gük, Uğur Alpar, Ali̇ Uğur Ünal, Zeynep Ertürk, Fatma Ali̇baz Öner, Güzi̇de Nevsun İnanç, Safi̇ye Atlas Tüli̇n Ergun, Rafi̇ Haner Di̇reskeneli̇
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to assess the relationships between the course of Behçet's disease (BD), disease-specific fears, and work productivity and activity impairment. Materials and methods: In this cross-sectional study, 110 consecutive BD patients were included. The Work Productivity and Activity Impairment questionnaire was used. Results: In the group of employed patients, 30.41% had missed work during the previous week. The mean percentages of daily activity impairment were higher in patients with musculoskeletal involvement (39.81 ± 33.61%) compared to those without (23.48 ± 32.45%) (P = 0.008). A greater decrease in working hours was observed in patients …
Genetic Association Analysis Of Erbb4 Polymorphisms With The Risk Ofschizophrenia Susceptibility In A Jordanian Population Of Arab Descent, Laith Aleitan, Sahar Al-Habahbeh, Rami Alkhatib
Genetic Association Analysis Of Erbb4 Polymorphisms With The Risk Ofschizophrenia Susceptibility In A Jordanian Population Of Arab Descent, Laith Aleitan, Sahar Al-Habahbeh, Rami Alkhatib
Turkish Journal of Medical Sciences
Background/aim: The ERBB4 gene encodes a transmembrane tyrosine kinase and is considered to be one of the risk genes of schizophrenia. Although there is evidence of the roles of genes and the environment in the etiology of schizophrenia, a comprehensive biological and genetic background of the disease is still lacking. The aim of this study is to assess whether genetic variation in the human ERBB4 gene is associated with vulnerability to schizophrenia in the Jordanian Arab population. Materials and methods: A total of 185 inpatients with schizophrenia participated in this study and 195 healthy genetically homogeneous individuals were also used …
Repeated Prevalence Studies Of Nosocomial Infections In One University Hospital In Serbia, Milena Ilic, Ljiljana Markovic-Denic
Repeated Prevalence Studies Of Nosocomial Infections In One University Hospital In Serbia, Milena Ilic, Ljiljana Markovic-Denic
Turkish Journal of Medical Sciences
Background/aim: Nosocomial infections occur worldwide and affect both developed and resource-poor countries. The aim of this paper was to determine the prevalence and risk factors for nosocomial infections in one Serbian hospital. Materials and methods: Three-point prevalence surveys were conducted in the Clinical Center of Kragujevac (1240 beds). The standard definitions for nosocomial infections of the Centers for Diseases Control and Prevention were used. The authors conducted surveys according to the same protocol. Results: The prevalence of infected patients and the overall prevalence of nosocomial infections was 6.2% and 7.1% in 2003, 4.6% and 4.6% in 2005, and 7.6% and …
Meloxicam And Diclofenac Do Not Change Vegf And Pdgf-Abserum Levels Of Platelet-Rich Plasma, Burkay Utku, Gürhan Dönmez, Gülri̇z Eri̇şgen, Şenay Akin, Ali̇ Haydar Demi̇rel, Feza Korkusuz, Mahmut Nedi̇m Doral
Meloxicam And Diclofenac Do Not Change Vegf And Pdgf-Abserum Levels Of Platelet-Rich Plasma, Burkay Utku, Gürhan Dönmez, Gülri̇z Eri̇şgen, Şenay Akin, Ali̇ Haydar Demi̇rel, Feza Korkusuz, Mahmut Nedi̇m Doral
Turkish Journal of Medical Sciences
Background/aim: Platelet-rich plasma (PRP) application has gained widespread interest for musculoskeletal injuries. Nonsteroidal antiinflammatory drugs are frequently used in sports medicine before and/or after PRP application. Our study seeks to determine whether serum levels of platelet-derived growth factor-AB (PDGF-AB) and vascular endothelial growth factor (VEGF) levels of PRP would be affected by nonsteroidal antiinflammatory drugs. Materials and methods: Two different final concentrations of diclofenac (0.5 6mu;g mL-1 and 2.5 6mu;g mL-1), meloxicam (0.8 μg mL-1 and 2.0 μg mL-1), and acetylsalicylic acid (final concentration 450 μm) were obtained in separate tubes with PRPs prepared from 20 healthy male volunteers. Medicine-free …
Retrospective Analysis Of Maternal, Fetal, And Neonatal Outcomesof Intrahepatic Cholestasis Of Pregnancy At Gazi University, Berri̇n Günaydin, Meri̇h Bayram, Meli̇s Altuğ, Semra Cevher, Nuray Bozkurt
Retrospective Analysis Of Maternal, Fetal, And Neonatal Outcomesof Intrahepatic Cholestasis Of Pregnancy At Gazi University, Berri̇n Günaydin, Meri̇h Bayram, Meli̇s Altuğ, Semra Cevher, Nuray Bozkurt
Turkish Journal of Medical Sciences
Background/aim: Maternal, fetal, and neonatal outcomes in parturients with intrahepatic cholestasis of pregnancy (ICP) have been retrospectively documented. We aimed to present pregnancy outcomes of parturients with ICP who underwent delivery. The study was conducted during a 1-year period. Materials and methods: After ethics committee approval, data from 1 January to 31 December 2015 were collected to identify parturients with ICP. Results: Ten out of 37 patients underwent normal spontaneous vaginal delivery (NSVD), and the remaining 27 parturients underwent cesarean section (CS). Five of 27 parturients underwent nonelective cesarean section, while 22 had elective cesarean delivery. As for NSVD deliveries, …
Evaluation Of Plantar Pressure Distributions In Patients With Anteriorcruciate Ligament Deficiency: Preoperative And Postoperative Changes, Engi̇n Çeti̇n, Mehmet Ali̇ Deveci̇, Murat Songür, Hamza Özer, Saci̇t Turanli
Evaluation Of Plantar Pressure Distributions In Patients With Anteriorcruciate Ligament Deficiency: Preoperative And Postoperative Changes, Engi̇n Çeti̇n, Mehmet Ali̇ Deveci̇, Murat Songür, Hamza Özer, Saci̇t Turanli
Turkish Journal of Medical Sciences
Background/aim: Anterior cruciate ligament (ACL) deficiency results in several kinematic changes in the lower extremities. The aim of this study is to define the plantar pressure parameters in ACL-deficient patients and to show the effect of ACL reconstruction on dynamic plantar pressure. Materials and methods: Forty patients with unilateral ACL rupture and 40 healthy controls were included in this study. Dynamic plantar pressures of both groups were recorded by the EMED SF-2 system during level walking. Thirteen of the patients who had ACL reconstructions with hamstring autografts (HS group) were reevaluated at an average of 14.5 months following the ACL …
Predictive Values Of Plasma Kl-6 In Bronchopulmonary Dysplasia In Preterm Infants, Di̇lek Di̇lli̇, Ahmet Özyazici, Arzu Dursun, Serdar Beken, Nurdan Di̇nlen Fettah, Aysegul Zenci̇roğlu, Nurullah Okumuş
Predictive Values Of Plasma Kl-6 In Bronchopulmonary Dysplasia In Preterm Infants, Di̇lek Di̇lli̇, Ahmet Özyazici, Arzu Dursun, Serdar Beken, Nurdan Di̇nlen Fettah, Aysegul Zenci̇roğlu, Nurullah Okumuş
Turkish Journal of Medical Sciences
Background/aim: It has been suggested that plasma KL-6 increases in premature infants with bronchopulmonary dysplasia (BPD). We aimed to evaluate the predictive values of KL-6 in BPD. Materials and methods: The study was performed in preterm neonates with birthweight ≤1500 g and gestational age ≤32 weeks. Plasma KL-6 levels were measured on postnatal days 1, 7, and 14. Results: BPD was identified in eight of the 28 study infants. On postnatal days 1 and 7, plasma KL-6 levels were similar in infants with BPD [on day 1: 8.9 (7.5-17.8) U/mL and on day 7: 16.8 (10.5-47.7) U/mL] and without BPD …
Role Of Hygienic Factors In The Etiology Of Allergic Disorders In Children, Şule Yeşi̇l, Ahmet Kan, Olkar Abdulmajed, Arzu Bakirtaş, Mahmut Nedi̇m Sultan, Mehmet Sadik Demi̇rsoy
Role Of Hygienic Factors In The Etiology Of Allergic Disorders In Children, Şule Yeşi̇l, Ahmet Kan, Olkar Abdulmajed, Arzu Bakirtaş, Mahmut Nedi̇m Sultan, Mehmet Sadik Demi̇rsoy
Turkish Journal of Medical Sciences
Background/aim: We investigated the role of body flora and chronic inflammatory infections in the etiology of allergic disorders in Turkish children. Materials and methods: Forty pediatric asthma patients with positive skin prick tests and 40 age-matched healthy subjects with negative skin prick tests were enrolled in this cross-sectional study. Serum H. pylori IgG, viral hepatitis serology, IL-10, and TGF-beta levels were measured. Stool and throat cultures were taken and tested for occurrence of microorganisms. Results: A significantly higher percentage of nonatopic subjects tested positive for anti-H. pylori antibodies compared to atopic subjects (60% vs. 20%). Serum IL-10 levels were also …
Assessment Of Developmental And Radiological Long-Term Outcomeof Children With Surgically Treated Midgut Volvulus, Ahmet Murat Çakmak, Özlem Boybeyi̇ Türer, Gülnur Göllü Bahadir, Bi̇lge Türedi̇, Ufuk Ateş, Adalet Elçi̇n Yildiz, Gonul Kucuk, Ömer Suat Fi̇toz, Betül Ulukol, Mustafa Kemal Aslan, Tutku Soyer, Hüseyi̇n Di̇ndar
Assessment Of Developmental And Radiological Long-Term Outcomeof Children With Surgically Treated Midgut Volvulus, Ahmet Murat Çakmak, Özlem Boybeyi̇ Türer, Gülnur Göllü Bahadir, Bi̇lge Türedi̇, Ufuk Ateş, Adalet Elçi̇n Yildiz, Gonul Kucuk, Ömer Suat Fi̇toz, Betül Ulukol, Mustafa Kemal Aslan, Tutku Soyer, Hüseyi̇n Di̇ndar
Turkish Journal of Medical Sciences
Background/aim: The aim is to evaluate the long-term outcome of asymptomatic patients who underwent surgical correction for midgut volvulus. Materials and methods: Seven patients managed surgically for midgut volvulus in the last 3 years were included. Demographic features, symptoms at presentation, diagnoses, surgical procedures, and complications were recorded. Patients were then contacted for followup and evaluation of long-term outcomes. General physical conditions, anthropometric parameters, feeding habits, and defecation histories were evaluated. Laboratory examinations were performed. Color Doppler ultrasonography (CDUS) was performed to evaluate blood flow in the superior mesenteric artery (SMA). Results: In total, seven patients were identified. The median …
Combination Therapy With Dendritic Cell-Based Vaccine And Anti-Cd69 Antibodyenhances Antitumor Efficacy In Renal Cell Carcinoma-Bearing Mice, Si Ming Wei, Hang Li Pan, Li Wang, Guo Li Yin, Kai Zhong, Ya Zhou, Shu Jiao Yang, Zhao Liang Xin
Combination Therapy With Dendritic Cell-Based Vaccine And Anti-Cd69 Antibodyenhances Antitumor Efficacy In Renal Cell Carcinoma-Bearing Mice, Si Ming Wei, Hang Li Pan, Li Wang, Guo Li Yin, Kai Zhong, Ya Zhou, Shu Jiao Yang, Zhao Liang Xin
Turkish Journal of Medical Sciences
Background/aim: Dendritic cell-based vaccine therapy for renal cell carcinoma is effective but requires improvement. Here we explored whether combination therapy with dendritic cell-based vaccine and anti-CD69 antibody can enhance antitumor efficacy in renal cell carcinoma-bearing mice. Materials and methods: Balb/c mice were challenged subcutaneously with murine renal cell carcinoma (Renca) cells. On day 3 after tumor cell inoculation, tumor-bearing mice either were left untreated or were treated with Renca tumor lysate-pulsed dendritic cells (i.e. dendritic cell-based vaccine), anti-CD69 antibody, or a combination of Renca tumor lysate-pulsed dendritic cells with anti-CD69 antibody. The mice were sacrificed on day 28. Tumor volume …
Rho/Rho-Kinase Signalling In Chronically Alcohol-Fed Mice, Havva Kubat, Ahmet Sencer Yurtsever, Kansu Büyükafşar
Rho/Rho-Kinase Signalling In Chronically Alcohol-Fed Mice, Havva Kubat, Ahmet Sencer Yurtsever, Kansu Büyükafşar
Turkish Journal of Medical Sciences
Background/aim: The effects of chronic ethanol consumption on male sexual function are debateable, and its effects on the Rho/ Rho-kinase pathway are unknown. Therefore, we investigated smooth muscle reactivity and Rho/Rho-kinase signalling in the corpus cavernosum of ethanol-fed mice. Materials and methods: Ethanol was added to drinking water at 5% concentration in the first 2 days with 5% increment every subsequent 2 days, up to a final concentration of 20% for 45 days. Corpora cavernosa were isolated and a cumulative dose-response curve to phenylephrine was obtained. Acetylcholine (10-6 M), electrical field stimulation (EFS, 40 V, 8-16 Hz) and Y-27632 (10-6-10-5 …
Molecular Characteristics And Antibiotic Resistance Of Acinetobacter Baumanniibeta-Lactamase-Producing Isolates, A Predominance Of Intrinsic Blaoxa-51, And Detection Oftem And Ctx-M Genes, Amir Ibrahimagic, Farah Kamberovic, Selma Uzunovic, Branka Bedenic, Emina Idrizovic
Molecular Characteristics And Antibiotic Resistance Of Acinetobacter Baumanniibeta-Lactamase-Producing Isolates, A Predominance Of Intrinsic Blaoxa-51, And Detection Oftem And Ctx-M Genes, Amir Ibrahimagic, Farah Kamberovic, Selma Uzunovic, Branka Bedenic, Emina Idrizovic
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine the molecular characteristics and antibiotic resistance of 13 (10 inpatient and three outpatient) Acinetobacter baumannii beta-lactamase-producing isolates collected in Bosnia and Herzegovina between December 2009 and May 2010. Materials and methods: Susceptibility testing was performed by disk diffusion and broth microdilution methods. The modified Hodge and combined disk test with EDTA/phenylboronic acid was used to screen for carbapenemase production. Production of extended spectrum beta-lactamases (ESBLs) was determined by double-disk synergy test. PCR was used to detect blaESBL/blacarb genes. Results: Ten (22.2%) inpatient and three (13.6%) outpatient isolates produced beta-lactamases, ESBLs, or …
Evaluation Of Major And Minor Lower Extremity Amputation In Diabetic Foot Patients, Firat Ozan, Kaan Gürbüz, İlhami̇ Çeli̇k, Zehra Beştepe Dursun, Erdal Uzun
Evaluation Of Major And Minor Lower Extremity Amputation In Diabetic Foot Patients, Firat Ozan, Kaan Gürbüz, İlhami̇ Çeli̇k, Zehra Beştepe Dursun, Erdal Uzun
Turkish Journal of Medical Sciences
Background/aim: We evaluated the existing risk factors with clinical results in patients who underwent major and minor amputation of the lower extremity as a result of diabetic foot ulcers (DFUs). Materials and methods: We retrospectively studied 107 patients who had undergone lower extremity amputation. The patients were divided into minor (Group 1, n = 75) and major (Group 2, n = 32) amputation groups. On clinical evaluation, the type of surgery performed, smoking history, comorbidities, duration of diabetes mellitus (DM) diagnosis, duration of DFU presence, peripheral neuropathy, peripheral arterial disease, results of deep tissue culture, length of hospitalization, and blood …