Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medical Specialties (76935)
- Public Health (53624)
- Medical Sciences (45193)
- Life Sciences (41792)
- Nursing (33613)
-
- Social and Behavioral Sciences (33510)
- Diseases (21511)
- Education (18837)
- Rehabilitation and Therapy (16400)
- Mental and Social Health (14503)
- Oncology (14281)
- Medical Education (13651)
- Dentistry (13252)
- Arts and Humanities (13157)
- Physical Sciences and Mathematics (10984)
- Veterinary Medicine (9760)
- Psychiatry and Psychology (9529)
- Pharmacy and Pharmaceutical Sciences (9473)
- Sports Sciences (9117)
- Pediatrics (9023)
- Health and Medical Administration (8920)
- Biomedical Informatics (8883)
- Psychology (8280)
- Sociology (8029)
- Public Health Education and Promotion (7957)
- Bioinformatics (7873)
- Medical Genetics (7020)
- Business (6810)
- Occupational Therapy (6667)
- Institution
-
- The Texas Medical Center Library (25819)
- Thomas Jefferson University (14803)
- Chulalongkorn University (11393)
- Washington University School of Medicine (10570)
- Aga Khan University (9490)
-
- University of Kentucky (8641)
- TÜBİTAK (8080)
- Walden University (6117)
- Virginia Commonwealth University (5357)
- University of Nebraska - Lincoln (5202)
- Edith Cowan University (5059)
- Western Michigan University (4737)
- American Dental Association (4410)
- Western Kentucky University (4285)
- Lehigh Valley Health Network (4070)
- University of Texas Rio Grande Valley (4027)
- Nova Southeastern University (3926)
- Universitas Indonesia (3627)
- Himmelfarb Health Sciences Library, The George Washington University (3623)
- University of Nebraska Medical Center (3618)
- Old Dominion University (3540)
- University of Nevada, Las Vegas (3343)
- Marquette University (3240)
- University of Alabama at Birmingham (3145)
- University of South Carolina (3140)
- Children's Mercy Kansas City (3009)
- Wright State University (2928)
- HCA Healthcare (2906)
- Western University (2883)
- University of North Dakota (2880)
- Keyword
-
- Humans (25811)
- Female (11933)
- Male (10544)
- Animals (7817)
- COVID-19 (6493)
-
- Adult (6124)
- Middle Aged (5238)
- Mice (5162)
- ICTS (Institute of Clinical and Translational Sciences) (5152)
- Aged (4689)
- Child (3549)
- Adolescent (3113)
- United States (2920)
- Nursing (2607)
- Education (2550)
- Obesity (2470)
- Mental health (2399)
- Depression (2362)
- Public health (2292)
- Retrospective Studies (2275)
- English (2266)
- Pregnancy (2203)
- Cancer (2183)
- Thomas Jefferson University (2017)
- Children (1995)
- Michigan (1973)
- Treatment Outcome (1916)
- Young Adult (1835)
- Infant (1767)
- Neoplasms (1667)
- Publication Year
-
- 2026 (15482)
- 2025 (24392)
- 2024 (26836)
- 2023 (26983)
- 2022 (23289)
-
- 2021 (20654)
- 2020 (19885)
- 2019 (15947)
- 2018 (15273)
- 2017 (14408)
- 2016 (12631)
- 2015 (11876)
- 2014 (9471)
- 2013 (7868)
- 2012 (7279)
- 2011 (6747)
- 2010 (5668)
- 2009 (4357)
- 2008 (3680)
- 2007 (3099)
- 2006 (2749)
- 2005 (2786)
- 2004 (2211)
- 2003 (1907)
- 2002 (1795)
- 2001 (1646)
- 2000 (1578)
- 1999 (1653)
- 1998 (1484)
- 1997 (1143)
- Publication
-
- Faculty, Staff and Student Publications (13671)
- Faculty, Staff and Students Publications (7831)
- 2020-Current year OA Pubs (7424)
- Walden Dissertations and Doctoral Studies (5875)
- Turkish Journal of Medical Sciences (4871)
-
- Theses and Dissertations (4194)
- Chulalongkorn Medical Journal (4154)
- Turkish Journal of Veterinary & Animal Sciences (3209)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (3086)
- International Journal of Exercise Science: Conference Proceedings (2674)
- The Thai Journal of Veterinary Medicine (2529)
- All ETDs from UAB (2525)
- Research outputs 2022 to 2026 (2400)
- Journal Articles (2387)
- Faculty Publications (2306)
- Electronic Theses and Dissertations (2238)
- Henry Ford Hospital Medical Journal (2151)
- Dissertations (1937)
- Loma Linda University Electronic Theses, Dissertations & Projects (1807)
- School of Medicine Publications (1704)
- Doctor of Nursing Practice Projects (1584)
- What's Happening (1535)
- Research outputs 2014 to 2021 (1525)
- Masters Theses (1503)
- Publications and Research (1495)
- Manuscripts, Articles, Book Chapters and Other Papers (1467)
- Dissertations and Theses (Open Access) (1411)
- Dartmouth Scholarship (1400)
- Reproductive Health (1317)
- Rehabilitation Practice and Science (1276)
Articles 6541 - 6570 of 322063
Full-Text Articles in Medicine and Health Sciences
Perceived Knowledge, Attitude, Practice, And Barriers Of Jordanian Nursing Faculty To Integrate Genomic Concepts In The Curriculum: A Cross-Sectional Descriptive Study, Rachel Joseph
Wisdom & Compassion: The LUSON Journal
Background: Rapid advances in genomics knowledge and the expansion of precision medicine have amplified expectations for nurses to integrate genomic concepts into education and clinical practice. Evidence regarding genomic knowledge, attitudes, practices, and barriers among nursing faculty in the Middle East is limited. To equip practicing and emerging nurses, faculty must be equipped. Faculty preparedness is critical to successful curriculum integration and to preparing future nurses for genomic-informed care.
Purpose: This study examined the perceived knowledge, attitudes, practices, and barriers related to integrating genomic concepts in the nursing curriculum among nursing faculty in Jordan.
Methods: A cross-sectional descriptive design was …
More Than Machines: Our Identity In Christ, Jerrod A. Boggs
More Than Machines: Our Identity In Christ, Jerrod A. Boggs
Wisdom & Compassion: The LUSON Journal
No abstract provided.
From The Leadership Desk, Elizabeth Whorley
From The Leadership Desk, Elizabeth Whorley
Wisdom & Compassion: The LUSON Journal
No abstract provided.
Volume 3, Issue 2 - Complete Issue
Volume 3, Issue 2 - Complete Issue
Wisdom & Compassion: The LUSON Journal
No abstract provided.
Comparison Of Total Distance And Sprint Distance Between Positions Of Division Ii Female Soccer Players, Tamas Sebestyen, Jonathan P. Bayer
Comparison Of Total Distance And Sprint Distance Between Positions Of Division Ii Female Soccer Players, Tamas Sebestyen, Jonathan P. Bayer
Research & Creative Achievement Day
Introduction: To manage player health, minimize injury, and optimize performance in NCAA Division II soccer, this study analyzed positional demands using GPS technology. The findings provide insights into enhancing training plans and recovery based on specific positions. Methods: NCAA Division II female soccer players were tracked during sixteen in-season competitions using 10 Hz GPS wearable technology. Players were grouped into tactical roles including Wing Backs (WB), Center Backs (CB), Defensive Midfielders (6), Attacking Midfielders (10), and Forwards (9). Key metrics analyzed included Total Distance (TD), Total Sprint Distance (TSD), and Distance per Minute (D/M). Results: Forwards (9) and attacking midfielders …
Care, Capitalism, And Croissants: Interprofessional Students Take On Business Of Healthcare In Paris, Beth A. Komay, Phoebe S. Enebechi, Selma Dzamalija, Nicole A. Sharp
Care, Capitalism, And Croissants: Interprofessional Students Take On Business Of Healthcare In Paris, Beth A. Komay, Phoebe S. Enebechi, Selma Dzamalija, Nicole A. Sharp
Research & Creative Achievement Day
The Business of Healthcare in Paris is a faculty-led study-away program that unites business, nursing, and other healthcare students in an immersive experience of global healthcare systems. The primary design of this course is around interprofessional learning that integrates coursework and cultural experiences from within the Midwest United States (US) and France. Students begin the course by visiting healthcare facilities and small alternative-therapy businesses in the US, gaining initial exposure to diverse care environments. They then travel to Paris and surrounding areas to explore comparable sites, including hospitals, an art therapy center, a residential rehabilitation facility, and small businesses providing …
Public Health Book Club, Ashia Meister, James W. Durst, Ameila Beyer, Kelly K. Freymiller, Julia I. Kunz, Jaci M. Winchell, Josephine M. Sandquist, Chloe F. Sand
Public Health Book Club, Ashia Meister, James W. Durst, Ameila Beyer, Kelly K. Freymiller, Julia I. Kunz, Jaci M. Winchell, Josephine M. Sandquist, Chloe F. Sand
Research & Creative Achievement Day
Introduction: This project describes the development and implementation of a book club focused on population health topics to promote learning, discussion, and community engagement. A public library is a safe space to host book club meetings due to its non-intimidating environment. All members of the community are welcome to participate. A book club was hosted on campus for members of the nursing cohort to attend. With a focus on public health, these book clubs build awareness, critical thinking, and community engagement around population health issues. Purpose: The promotion of a book club can improve health literacy in the community by …
Health Education For Caregivers Of Individuals With Intellectual And Developmental Disability (Idd), Madison M. Conlin, Jack Lux, Megan Hesse, Sadie Olson, Violet Nelson, Christina Chao, Anna Peterson, Johanna Shubert
Health Education For Caregivers Of Individuals With Intellectual And Developmental Disability (Idd), Madison M. Conlin, Jack Lux, Megan Hesse, Sadie Olson, Violet Nelson, Christina Chao, Anna Peterson, Johanna Shubert
Research & Creative Achievement Day
Background: Winona State University nursing students partner with Home and Community Options (HCO) during their population health clinical experience. HCO’s mission is to “empower and support people with developmental disabilities,” with a vision of ensuring that all individuals thrive and are valued members of their communities (Home and Community Options, n.d.). The Healthcare Director at HCO identified a need for additional staff education related to common health conditions affecting individuals with intellectual and developmental disabilities (IDD), including arthritis, diabetes, and depression or other mental health concerns. In response to this identified need, nursing students developed evidence-based educational strategies to enhance …
A Collaborative Approach To Strengthening Behavioral Strategies To The Arcadia School District, Mallory Arndt, Sada Stanley, Ariana Huntington, Erin Janiszewski, Syndey Graf, Josie Becker, Bailey Ripley, Dana Jones, Gabby Rinowski, Luke Garner, Hailey Schliep
A Collaborative Approach To Strengthening Behavioral Strategies To The Arcadia School District, Mallory Arndt, Sada Stanley, Ariana Huntington, Erin Janiszewski, Syndey Graf, Josie Becker, Bailey Ripley, Dana Jones, Gabby Rinowski, Luke Garner, Hailey Schliep
Research & Creative Achievement Day
The School District of Arcadia is lacking mental health resources due to budget cuts from state and federal levels. Mental health needs have become a rising concern in recent years. With that, the guidance counselors, who traditionally supported students' emotional regulation and behavioral needs, became increasingly occupied with Academic and Career Planning requirements, leaving them with limited time to address students' mental health needs. To help address this need, Winona State University nursing students partnered with the district's guidance counselors to develop supplemental emotional management and decision-making skills-building videos that counselors could use during busy periods to support students' coping …
The Role Of Group Guidance With Psychodrama In Promoting Self-Adjustment: Does It Really Work For Adolescents?, Hanifa Salsa Bila, Dian Ari Widyastuti, Sri Tutur Martaningsih, Agungbudiprabowo Agungbudiprabowo, Taquddin Abd Mukti
The Role Of Group Guidance With Psychodrama In Promoting Self-Adjustment: Does It Really Work For Adolescents?, Hanifa Salsa Bila, Dian Ari Widyastuti, Sri Tutur Martaningsih, Agungbudiprabowo Agungbudiprabowo, Taquddin Abd Mukti
Buletin Konseling Inovatif
This study aimed to examine the effectiveness of group guidance using psychodrama techniques in improving self-adjustment among students. The study employed a quantitative approach with an experimental research design, specifically a pretest–posttest control group design. The participants consisted of ten students, divided into an experimental group of five students and a control group of five students. The experimental group received group guidance with psychodrama techniques, while the control group received treatment as usual. The research participants were selected using a simple random sampling technique. Data were collected using a self-adjustment scale, which had been analyzed for validity and reliability using …
Beyond The Numbers: Supporting Young Adults With Diabetes In The Transition To Adulthood, Alexis Salkovick
Beyond The Numbers: Supporting Young Adults With Diabetes In The Transition To Adulthood, Alexis Salkovick
Honors Projects
This project focuses on the transition to adulthood for young people with diabetes, a chronic medical condition. Both Type 1 and Type 2 diabetes are included. The main research focus is two-part: first examining this transition including barriers to health care, changes in lifestyle, and mental health, and then creating a new, innovative tool to support young adults with diabetes. An independent literature review was conducted to investigate diabetes management, barriers to health care, how transitioning to adulthood impacts diabetes care, and the importance of patient support systems. Then, a board game was developed with the dual purpose of educating …
Modulating Acute Stress Reactivity: Behavioral Interventions And Caffeine-Linked Stress Physiology In College Students, Kaitlyn Smith
Modulating Acute Stress Reactivity: Behavioral Interventions And Caffeine-Linked Stress Physiology In College Students, Kaitlyn Smith
Honors Theses
College students frequently rely on caffeine to manage academic demands, yet its physiological and psychological effects on acute stress remain poorly understood. Although caffeine is known to increase cardiovascular arousal and self‑reported anxiety, little research has compared different caffeine sources within the same individuals or examined whether brief behavioral interventions can buffer these effects. Self‑affirmation, a short writing exercise centered on personal values, has been shown to reduce stress reactivity, but its interaction with caffeine‑induced arousal has not been tested. This within‑subjects study examines how coffee, energy drinks, and a no‑caffeine control influence acute cardiovascular and self‑reported stress responses, and …
Glp-1 Receptor Agonists In Diabetic Foot And Ankle Care: Skeletal Liability Or A Blessing In Disguise? A Scoping Review, Daniela Lizbeth Avilez, Amanda Killeen
Glp-1 Receptor Agonists In Diabetic Foot And Ankle Care: Skeletal Liability Or A Blessing In Disguise? A Scoping Review, Daniela Lizbeth Avilez, Amanda Killeen
School of Podiatric Medicine - Student Research
Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly prescribed for glycemic control and weight reduction in patients with Type 2 Diabetes Mellitus (T2DM). Patients with T2DM exhibit elevated fracture risk despite preserved bone mineral density due to impaired bone quality and microarchitectural compromise. Whether GLP-1 RA therapy exacerbates or mitigates skeletal risk remains clinically relevant to podiatric care.
Hypothesis: We hypothesized that GLP-1 RA therapy is not associated with increased lower extremity fracture risk and may demonstrate protective trends influenced by age and duration of therapy.
Methods: A review of PubMed and Google Scholar (2010–2026) was conducted. Inclusion criteria …
An Ot Educational Program For Individuals With Upper And Lower Limb Amputations, Laurie R. Spinks Mrs, Cassandra Nelson
An Ot Educational Program For Individuals With Upper And Lower Limb Amputations, Laurie R. Spinks Mrs, Cassandra Nelson
Spring 2026 OTD Capstone Symposium
An OT approach to reducing prosthetic abandonment with an accessible guide to promote self sufficiency and community connections for individuals with amputations.
Quantification Of Mouse Tracheal Epithelial Cell Differentiation With Cilia Defects, Olivia V. Allen
Quantification Of Mouse Tracheal Epithelial Cell Differentiation With Cilia Defects, Olivia V. Allen
Honors Thesis
Primary Ciliary Dyskinesia (PCD) is an autosomal recessive disorder that affects 1 in every 7,500 live births. PCD results from motile cilia defects, impairing mucociliary clearance and causing chronic respiratory infections. Our lab studies include three PCD mouse lines — bgh (Spef2), nm1054 (Cfap221), and Cfap54gt/gt (Cfap54). Prior transcriptomic data led us to hypothesize that PCD mutant mouse tracheal epithelial cells (MTECs) exhibit reduced differentiation into ciliated cells. MTECs from the trachea of the Wild Type (WT) and the PCD mutant mouse lines were cultured at an Air Liquid Interface (ALI) to start …
Sudden Cardiac Arrest & Newly Diagnosed Arrhythmogenic Cardiomyopathy In A High School Athlete, Jacob Rolfes, Brent Holtgrewe, Mike Tzianos
Sudden Cardiac Arrest & Newly Diagnosed Arrhythmogenic Cardiomyopathy In A High School Athlete, Jacob Rolfes, Brent Holtgrewe, Mike Tzianos
2026 Student Academic Showcase
A high school soccer player experienced sudden cardiac arrest during competition and required immediate CPR and AED use. Following resuscitation, physicians ruled out commotio cordis and identified findings consistent with arrhythmogenic cardiomyopathy, supported by a prolonged T-wave on EKG while all other laboratory and catheterization results were normal. The athlete later received an ICD and pacemaker, prompting significant physical, emotional, and lifestyle adjustments. This capstone project examines the emergency response, the role of trained medical personnel at sporting events, and the implications of early cardiac screening for adolescent athletes. Through consented family interviews, structured questionnaires, and case-based data collection, the …
Longitudinal Fueling Status Of High School Female Athletes, Kaylee Turner, Abigail Rickermann
Longitudinal Fueling Status Of High School Female Athletes, Kaylee Turner, Abigail Rickermann
2026 Student Academic Showcase
Low energy availability (LEA) is a clinically significant concern in adolescent female athletes due to its impact on growth and development, bone health, hormonal function, performance, recovery, and cognitive outcomes. Despite established associations, a clear longitudinal understanding of how LEA relates to injury and illness rates across an academic year remains limited, representing a clinical gap in athletic training and sports medicine literature. The purpose of this capstone project was to develop a comprehensive Institutional Review Board (IRB) protocol to support a future longitudinal investigation examining LEA and its relationship to injury and illness incidence in high school female athletes. …
The Necessity Of Adaptive Sports: Addressing Financial Barriers To Participation In Children With Spinal Cord Injuries, Megan G. Wells
The Necessity Of Adaptive Sports: Addressing Financial Barriers To Participation In Children With Spinal Cord Injuries, Megan G. Wells
Student Capstone Papers
Children with spinal cord injuries (SCIs) experience numerous barriers to participation in adaptive sports despite the well-established physical, psychosocial, and developmental benefits of physical activity. Financial constraints, limited awareness of funding opportunities, and the complexity of grant application processes often prevent families from accessing adaptive sports programs and specialized equipment. The purpose of this doctoral capstone project was to develop a comprehensive financial guidebook for families of children with SCIs to address financial barriers to adaptive sports participation, promote physical activity, and improve overall quality of life. Guided by the Person-Environment-Occupation-Performance (PEOP) model, this doctoral capstone project addressed financial accessibility …
Effectiveness Of Rule Modification And Contact Exposure Reduction In Adolescent Contact Sports, Alex Martin
Effectiveness Of Rule Modification And Contact Exposure Reduction In Adolescent Contact Sports, Alex Martin
2026 Student Academic Showcase
Clinical Question: In adolescent athletes participating in contact sports, does rule modification or contact restriction reduce sport-related concussion incidence compared with standard full-contact rules? Background: Sport-related concussion remains a major concern in youth athletics. Structural prevention strategies, such as limiting contact exposure, have been proposed as effective approaches, though their comparative effectiveness remains under review. Methods: A critically appraised topic (CAT) was conducted using Google Scholar to identify peer-reviewed studies from the past 15 years examining rule modification or contact restriction as primary prevention strategies. Six high-quality studies met inclusion criteria, including one meta-analysis, one systematic review, prospective cohort studies, …
Understanding The Impact Of Therapeutic Recreation On Patient Outcomes, Faith Atkins, Emma Jones
Understanding The Impact Of Therapeutic Recreation On Patient Outcomes, Faith Atkins, Emma Jones
2026 Student Academic Showcase
This exploratory project examines the role of Therapeutic Recreation (TR) in improving overall well-being and quality of life for individuals across diverse populations. The purpose of this project is to analyze how leisure-based interventions can be adapted to meet the physical, cognitive, emotional, and social needs of patients in various settings. By synthesizing current research and professional practices, this project highlights how TR contributes to rehabilitation, identity rebuilding, and long-term wellness. The project focuses on how recreational therapists use individualized, evidence-based approaches to help patients re-engage in meaningful activities following injury, illness, or disability. It also explores the impact of …
Clinical Evaluation And Rehabilitation Of A Complex Non-Contact Knee Injury In A Collegiate Athlete, Shelby Pritt
Clinical Evaluation And Rehabilitation Of A Complex Non-Contact Knee Injury In A Collegiate Athlete, Shelby Pritt
2026 Student Academic Showcase
This case follows the rehabilitation of a 22-year-old collegiate lacrosse player recovering from a complex knee injury. During the initial evaluation, the athlete presented with pain, swelling, and limited active range of motion, secondary to pain. The rehabilitation protocol used a combination of ACL, MCL, and meniscus standardized rehabilitation parameters. The primary goal of rehabilitation was to safely return the athlete play the following season. This case highlights the importance of knee health and the role of preventative exercise programs in reducing injury risks. This case covers the rehabilitation of a complex right knee injury primarily focusing on a complete …
Fitness For All: Education For Gym Staff Supporting People With Disabilites, Bianca Loor, Mary Jan Greer, Alison Skean
Fitness For All: Education For Gym Staff Supporting People With Disabilites, Bianca Loor, Mary Jan Greer, Alison Skean
Spring 2026 OTD Capstone Symposium
This capstone project, “Fitness for All: Education for Gym Staff Supporting People with Disabilities,” focuses on improving accessibility and inclusion within community fitness settings through staff education. Individuals with disabilities often encounter barriers in gyms due to limited staff training, lack of confidence, and insufficient knowledge of adaptive fitness practices.
To address this gap, a comprehensive, evidence-based training program was developed and implemented for gym staff at Crunch Fitness Orange Park. The program incorporated occupational therapy frameworks, including the Person-Environment-Occupation (PEO) model and the Occupational Therapy Practice Framework (OTPF-4), to promote inclusive and client-centered fitness practices.
Using a mixed-methods approach, …
Sensory-Friendly Environments In Schools, Jocelyn A. Ashworth, Rebecca King
Sensory-Friendly Environments In Schools, Jocelyn A. Ashworth, Rebecca King
Spring 2026 OTD Capstone Symposium
Sensory-Friendly Environments in Schools focuses on strengthening sensory-motor lab use and building educator understanding to support students with sensory processing difficulties. Implemented at Sparta Elementary School within Belton ISD, with the goal to enhance students' regulation, attention, and participation in daily school activities by equipping educators with practical, sustainable sensory strategies.
Project Evaluation Of A Workplace Violence Prevention Program At A Rural Hospital, Stacy Ochoa-Sofoifa, Yolanda L. Rodriquez, Melissa Bowe, Teresa Mendoza
Project Evaluation Of A Workplace Violence Prevention Program At A Rural Hospital, Stacy Ochoa-Sofoifa, Yolanda L. Rodriquez, Melissa Bowe, Teresa Mendoza
Publications 2026-present
No abstract provided.
Optimization Of Pediatric Multidetector Ct Imaging Parameters Using A Machine Learning–Based Monte Carlo Simulation Model, Ali O. Masoud, Adithya Rajnaryanan, Khamis O. Amour, Ahmed M. Jusabani, Justin E Ngaile, Manoj Kumar, Mwingereza John Kumwenda Dr
Optimization Of Pediatric Multidetector Ct Imaging Parameters Using A Machine Learning–Based Monte Carlo Simulation Model, Ali O. Masoud, Adithya Rajnaryanan, Khamis O. Amour, Ahmed M. Jusabani, Justin E Ngaile, Manoj Kumar, Mwingereza John Kumwenda Dr
Tanzania Journal of Science
This study utilized Monte Carlo (MC) simulations to optimize radiation doses in pediatric multidetector computed tomography (MDCT) head scans by analyzing key parameters like tube current (mA), tube voltage (kV), pitch, and slice thickness. The findings indicate that reducing tube current significantly lowers the Computed Tomography Dose Index (CTDIvol) and Dose Length Product (DLP), effectively minimizing patient radiation exposure. Higher pitch values (0.7–0.9) further reduced radiation by decreasing beam overlap, while using a thinner slice thickness (0.6 mm) improved dose efficiency. A comparison highlighted the effectiveness of optimization: simulated parameters kVp 100, mAs 81, pitch 0.98 yielded a CTDIvol of …
Mitochondrial Dna Replication Is Regulated By Endoplasmic Reticulum-Mitochondrial Contact Sites, The Mitochondrial Calcium Uniporter, And Manganese, Amaia Lopez De Arbina, Angelica Zamudio-Ochoa, Mikel Muñoz-Oreja, Diego Perez-Rodriguez, Laura Mosqueira-Martín, Rebecca Lasalandra, Marina Villar-Fernandez, Uxoa Fernandez-Pelayo, Laura Rodriguez-Gomez, Seungtae Lee, Francisco Gil-Bea, Nerea Osinalde, Ainara Vallejo-Illaramendi, Dmitry Temiakov, Antonella Spinazzola, Ian Holt
Mitochondrial Dna Replication Is Regulated By Endoplasmic Reticulum-Mitochondrial Contact Sites, The Mitochondrial Calcium Uniporter, And Manganese, Amaia Lopez De Arbina, Angelica Zamudio-Ochoa, Mikel Muñoz-Oreja, Diego Perez-Rodriguez, Laura Mosqueira-Martín, Rebecca Lasalandra, Marina Villar-Fernandez, Uxoa Fernandez-Pelayo, Laura Rodriguez-Gomez, Seungtae Lee, Francisco Gil-Bea, Nerea Osinalde, Ainara Vallejo-Illaramendi, Dmitry Temiakov, Antonella Spinazzola, Ian Holt
Department of Biochemistry and Molecular Biology Faculty Papers
Mitochondrial DNA replication occurs at contact sites between the endoplasmic reticulum (ER) and mitochondria (ERMCS). Beyond the known role of the tubular ER protein RTN4, the factors regulating this process are poorly defined. Here, we show that repressing the ER protein ERLIN2 in human fibroblasts depletes ER-mitochondrial contact sites and inhibits mitochondrial DNA replication, as does silencing RTN4 or the ER-mitochondrial tether GRP75. GRP75 or RTN4 scarcity also decreases the level of the mitochondrial calcium uniporter (MCU), whose inhibition blocks mitochondrial DNA synthesis. Because ERMCS depletion did not diminish mitochondrial calcium, and MCU complex can transport manganese, we tested whether …
Family-Based Gwas Of Cognitive Endophenotypes Reveals Genetic Architecture Of Memory And Executive Function In Alzheimer’S Disease, Kesheng Wang, Xueying Yang, Gayenell Magwood, Chun Xu, R. Osvaldo Navia, Jean Neils-Strunjas, Xiaoming Li
Family-Based Gwas Of Cognitive Endophenotypes Reveals Genetic Architecture Of Memory And Executive Function In Alzheimer’S Disease, Kesheng Wang, Xueying Yang, Gayenell Magwood, Chun Xu, R. Osvaldo Navia, Jean Neils-Strunjas, Xiaoming Li
Health & Biomedical Sciences Faculty Publications
Alzheimer’s disease (AD), the most common cause of dementia, is characterized by progressive memory and cognitive decline. Conventional genome-wide association studies (GWAS) comparing AD cases and controls may miss genetic influences that act along a continuum of cognitive function. Using data from 3007 participants in the National Institute on Aging Late-Onset Alzheimer’s Disease Family Study (NIA-LOAD GWAS), we conducted a family-based GWAS of eight quantitative cognitive phenotypes encompassing episodic memory (Logical Memory IA and IIA), working memory (Digit Span Forward, Backward, and Ordering), and semantic fluency (Animal, Fruit and Vegetable, and Vegetable Fluency). Family-based association testing in PLINK v1.9 identified …
Theory And Simulations Of Delayed Stochastic And Deterministic Models Of Prion Diseases, Gangadhara Boregowda, Omar Sharif, Daniel Gutierrez Iii, Allegra Simmons, Laurent Pujo-Menjouet, Tamer Oraby, Michael R. Lindstrom
Theory And Simulations Of Delayed Stochastic And Deterministic Models Of Prion Diseases, Gangadhara Boregowda, Omar Sharif, Daniel Gutierrez Iii, Allegra Simmons, Laurent Pujo-Menjouet, Tamer Oraby, Michael R. Lindstrom
School of Mathematical & Statistical Sciences Faculty Publications
Neurodegenerative diseases (NDs), such as Alzheimer’s, Parkinson’s, and prion diseases, are characterized by the dynamical spread of toxic proteins through the brain. In prion diseases, cellular prion protein (PrPC), produced by neurons, misfolds into a toxic form, known as scrapie prion protein (PrPSc). PrPSc induces neuronal stress which ultimately leads to cell death. In this paper, we develop mathematical models for the progression of prion diseases, incorporating a cellular defense mechanism that introduces a delay term affecting protein translation and a volatility term accounting for unaccounted biological factors influencing the system. We also extend the model to capture the spatial …
Latent Class Patterns Of Medication Attitudes And Their Correlates Among Older Adults In The United States, Jiaming Liang, Min Ji Kwak, Mona Shirvani, Alexander Testa, Rafael Samper-Ternent, Zhigang Xie, Jack Tsai
Latent Class Patterns Of Medication Attitudes And Their Correlates Among Older Adults In The United States, Jiaming Liang, Min Ji Kwak, Mona Shirvani, Alexander Testa, Rafael Samper-Ternent, Zhigang Xie, Jack Tsai
Faculty, Staff and Student Publications
No abstract provided.
Identification Of Lipid Quantitative Trait Loci Linked With Cardiometabolic Disease In Asian Indians And Europeans: A Genome-Wide Association Study And Mendelian Randomization, Madhusmita Rout, Christopher E. Aston, Ravindranath Duggirala, Harald H. H. Goring, Oliver Fiehn, Dharambir K. Sanghera
Identification Of Lipid Quantitative Trait Loci Linked With Cardiometabolic Disease In Asian Indians And Europeans: A Genome-Wide Association Study And Mendelian Randomization, Madhusmita Rout, Christopher E. Aston, Ravindranath Duggirala, Harald H. H. Goring, Oliver Fiehn, Dharambir K. Sanghera
School of Medicine Publications
Background: Genetic mechanisms that predispose people to type 2 diabetes (T2D) and cardiovascular disease (CVD) remain poorly understood, partly because of a lack of sufficient data on non-European ethnic groups. Extending these evaluations to diverse cohorts is essential for gaining insights into the molecular pathways involved in disease development among human populations. In this study, we aimed to evaluate the genetic connection between the human lipidome and cardiometabolic disorders. We conducted a metabolite genome-wide association study (mGWAS) in a Punjabi population from India, along with multi-layer replication studies using the UK Biobank and other independent European and non-European cohorts.
Methods …