Medicine and Health Sciences Commons^™

Do Leukotriene Inhibitors/Modifiers Reduce Symptoms Associated With Nasal Polyps?, Dallas A. Knox

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this systematic review is to determine how well leukotriene inhibitors/modifiers reduce symptoms associated with nasal polyps.

Study Design: The studies included in this review are three randomized controlled trials.

Data Source: The three RCTs in this review were obtained by performing a PubMed search using the keywords “nasal polyp”, “leukotriene”, and “Montelukast”. All articles were published in English and in peer-reviewed journals.

Outcomes Measured: The three studies determine whether there was significant improvement of symptoms in patients with nasal polyps who were treated adjunctively with leukotriene inhibitors/modifiers. The symptoms were measured before and after the treatments …

Is Virtual Reality An Effective Pain Management Treatment During Wound Care Of Pediatric Burn Patients?, Angelica Mcgowan

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not “Is virtual reality an effective pain management treatment during the wound care of pediatric burn patients?”

Study Design: Systematic review of three randomized controlled trials (RCTs) published, in English, in peer-reviewed journals between 2008-2014.

Data Sources: The three RCTs were found using the PubMed and Ovid databases.

Outcomes measured: All three studies measured pain perception and intensity using self-reporting questionnaires, and visual analogue scales.

Results: Jeffs et al. and Miller et al. both showed that patients using the virtual reality (VR) or augmented reality (AR) mechanisms …

Is Maintaining A Gluten-Free Diet Effective In Decreasing Symptoms For Irritable Bowel Syndrome?, Christina T. Larkin

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not a gluten-free diet is effective in decreasing symptoms for irritable bowel syndrome (IBS).

Study Design: Systemic review of three randomized, double-blind, placebo-controlled trials published between 2010-2016, all in the English language.

Data Sources: Data sources obtained for this review were studies published in peer reviewed journals found using PubMed Database and were selected based on outcomes measured and relevance to the objective.

Outcomes Measured: The outcomes measured were based on reduction in abdominal symptoms in IBS patients. Outcomes were measured by a series of 10 cm …

Does Mesalazine Improve The Symptoms Of Patients With Irritable Bowel Syndrome (Ibs)?, Carrie A. Loper

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The purpose of this EBM review is to determine, “Does Mesalazine improve the symptoms of patients with irritable bowel syndrome (IBS)?”.

STUDY DESIGN: Review of three English language primary studies, published between 2011 and 2016.

DATA SOURCES: Three randomized controlled trials (RCTs) were found through the Cochrane Library, Embase, and PubMed. These studies analyzed the effectiveness of Mesalazine in treating the symptoms of patients with IBS.

OUTCOMES MEASURED: The outcomes measured included relief of abdominal pain (primary outcome) and abdominal pain intensity. The outcomes were measured by a binary scale (“yes” or “no” or relief of pain, pain severity …

Is Duloxetine Effective In Reducing Pain For Patients With Diabetic Neuropathy?, Hee Namgoong

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not duloxetine is effective in reducing pain for patients with diabetic neuropathy.

STUDY DESIGN: Systematic review of three English language Randomized Controlled Trials, published between 2010-2015.

DATA SOURCES: Three randomized controlled trials published in peer-reviewed journals comparing the effects of Duloxetine on diabetic neuropathy pain found using the Embase database.

OUTCOME MEASURES: The outcomes were measured by assessing diabetic neuropathy pain reduction, using the Brief Pain Inventory (BPI) average pain item, BPI- severity scale, BPI- interference. Also, individual health outcome was measured by using Patient Global Impression …

Are Oral Steroids As Effective As Nsaids In Relieving Patient Pain From Gout?, Haley T. Peeples

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is the determine whether or not, “oral steroids are as effective as NSAIDS in relieving patient pain from gout?”

STUDY DESIGN: Review of three English language primary studies, published between 2008 and 2016.

DATA SOURCES: Three randomized controlled trials (RCTs) were found using PubMed and Embase database. These studies analyzed the effectiveness of steroids in relieving patient pain from gout.

OUTCOMES MEASURED: The major outcomes measured were improvements in joint tenderness on palpation, joint erythema, joint swelling, and joint activity measured on a 5-point Likert scale. (0=no pain, 1=mild pain, 2=moderate pain, …

Are Inverse Agonists Of The Histamine H3 Receptor Effective In Reducing Excessive Daytime Sleepiness (Eds) In Individuals With Sleep Disorders?, Kelly-Ann Peters

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this systematic review is to determine whether or not “Are inverse agonists of the Histamine H3 receptor effective in reducing excessive daytime sleepiness (EDS) in individuals with sleep disorders?”

DESIGN: Review of two randomized controlled trials and one cross-sequential pilot study. All studies were primary sources, published in the English language and from 2008-2017.

DATA SOURCES: A single-blind, placebo controlled, cross-sequential study comparing an H3 inverse agonist to placebo in narcoleptics. Two randomized, double-blind, placebo controlled studies; one in narcoleptic patients and one in obstructive sleep apnea (OSA) patients. All studies found using PubMed and Cochrane …

Are Curcuminoids Effective In Improving Physical Function In Patients With Knee Osteoarthritis?, Lacey A. Miranda

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not curcuminoids are effective in improving physical function in patients with knee osteoarthritis.

Study Design: Review of a double-blind randomized control trial, a randomized control trial, and a randomized single-blind placebo-controlled trial.

Data Sources: The articles were found on PubMed and selected based on the relevance to the clinical question and if they were focused on patient-oriented evidence that matters (POEM).

Outcomes Measured: The outcomes were based solely on function measures using a patient rated WOMAC scale (WOMAC function) (patient satisfaction of treatment on a 5-category scale …

Is Botulinum Toxin A An Effective Treatment For Treating Children Who Have Lower Limb Spasticity From Cerebral Palsy?, Lauren Terrell

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not botulinum toxin A is an effective treatment for children who have lower limb spasticity from cerebral palsy.

STUDY DESIGN: The study by Carraro et al was a randomized double-blind clinical trial done in 2015.6The study done by Kim et al was a randomized, double-blind controlled clinical trial done in 2010.7 The study by Py et al was a clinical trial done in 2005-2006.8

DATA SOURCES: Data sources obtained for this review were articles published in peerreviewed journals found using PubMed Database.

OUTCOMES MEASURED: The outcome measured …

Is Transcatheter Aortic Valve Replacement Associated With A Decreased Mortality Rate When Compared To Surgical Aortic Valve Replacement In Patients With Severe Aortic Stenosis?, Ben Singleton

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM was to investigate the question, “Is the transcatheter aortic valve replacement associated with a decreased mortality rate when compared to the surgical aortic valve replacement method in patients with severe aortic stenosis?”

Study Design: systematic review of 3 English language primary studies, published between 2013 and 2015.

Data Sources: Three Randomized Controlled Trials (RCT’s) published on or after 2010 were selected based on their relevance to the proposed questions via PubMed. All three RCT’s compared transcatheter aortic valve replacement (TAVR) vs. surgical aortic valve replacement (SAVR) in patients with severe aortic stenosis.

Outcomes …

Is Dupilumab A Safe And Effective Treatment For Patients With Moderate-To-Severe Atopic Dermatitis?, Alanna M. Viken

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not dupilumab is a safe and effective treatment for patients with moderate-to-severe atopic dermatitis

Study Design: Review of three randomized, double blind, placebo control trials between 2014- 2016.

Data Sources: Three randomized, double blind, placebo controlled trials were found via EBSCOHost and PubMed.

Outcomes Measured: In all three randomized controlled trials, outcomes measured includes the IGA score. Moderate-to-severe atopic dermatitis is a 3 or 4 on the IGA scale, respectively, while the goal was to get patients to a 0-1 on the IGA scale (indicating clear or …

Are Curcuminoids Effective In Reducing Knee Pain In Adults With Knee Osteoarthritis?, Katie Jo Wacker

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not curcuminoids are effective in reducing knee pain in adults with knee osteoarthritis.

STUDY DESIGN: A review of two English language double-blind placebo-controlled randomized controlled trials and one double-blind randomized control trial (RCT) published within peer-reviewed journals after the year 2013. The studies include adult participants age 40 and over.

DATA SOURCES: Double-blind randomized controlled trials were found using PubMed database. These studies compared treatment with curcuminoids with ibuprofen or a placebo.

OUTCOMES MEASURED: Clinical outcomes of pain, stiffness and function were measured using the traditional Western …

Does The Use Of Prophylactic Probiotics Prevent Antibiotic-Associated Diarrhea In Adults Using One Or More Antibiotics?, David E. Castillo

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective Evidence Based Medicine (EBM) review is to determine if the use of probiotics can prevent the incidence of antibiotic-associated diarrhea (AAD) in adults using one or more antibiotics.

STUDY DESIGN: Systematic review of three randomized, double-blind, placebo controlled trials in the English language published between 2013 and 2014.

DATA SOURCES: Data sources obtained for this review were articles published in peerreviewed journals found using PubMed and Cochrane databases.

OUTCOME MEASURED: All three studies defined diarrhea as the passage of three or more loose stools in a 24-hour period. All the studies used the Bristol …