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Do Cdk 4/6 Inhibitors, In Combination With Anti-Estrogen Therapy, Improve Morbidity And Mortality In Women With Advanced Breast Cancer Compared To Anti-Estrogen Therapy Alone?, Kayla Mercado
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this selective EBM review is to determine whether or not CDK 4/6 inhibitors, in combination with anti-estrogen therapy, improve morbidity and mortality for women with advanced breast cancer compared to anti-estrogen monotherapy.
Study Design: Systematic review of three randomized-controlled trials. All three articles were published in English between 2015 and 2016.
Data Sources: Two randomized, double-blinded, placebo-controlled trials and one open-label randomized controlled trial found using PubMed and NCBI.
Outcomes Measured: Each study assessed morbidity and mortality based on progression-free survival or overall clinical benefit (stable disease, partial response, or complete response by 24 weeks).
Results: …