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PCOM Physician Assistant Studies Student Scholarship

Theses/Dissertations

2018

Adalimumab

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Does Adalimumab Prevent The Loss Of Visual Acuity In Patients With Uveitis?, Michael Moore Jan 2018

Does Adalimumab Prevent The Loss Of Visual Acuity In Patients With Uveitis?, Michael Moore

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not adalimumab prevents the loss of visual acuity in patients with uveitis.

STUDY DESIGN: Review of three English language primary studies published between 2013-2016.

DATA SOURCES: Two randomized controlled phase 3 trials and one retrospective study were found using PubMed. The RCT’s compared treatment with adalimumab to placebo in patients with noninfectious uveitis, while the retrospective study solely assessed outcomes in patients with noninfectious uveitis receiving adalimumab treatment.

OUTCOMES MEASURED: For the two RCT’s, the clinical outcome of time to treatment failure due to worsening visual acuity …