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Articles 1711 - 1740 of 2038

Full-Text Articles in Medicine and Health Sciences

Striking A Balance, Edward C. Halperin Jan 2015

Striking A Balance, Edward C. Halperin

NYMC Faculty Publications

No abstract provided.

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Live Virus Vaccines Based On A Yellow Fever Vaccine Backbone: Standardized Template With Key Considerations For A Risk/Benefit Assessment, Thomas P. Monath, Stephen J. Seligman, James S. Robertson, Bruno Guy, Edward B. Hayes, Richard C. Condit, Jean Louis Excler, Lisa Marie Mac, Baevin Carbery, Robert T. Chen Jan 2015

Live Virus Vaccines Based On A Yellow Fever Vaccine Backbone: Standardized Template With Key Considerations For A Risk/Benefit Assessment, Thomas P. Monath, Stephen J. Seligman, James S. Robertson, Bruno Guy, Edward B. Hayes, Richard C. Condit, Jean Louis Excler, Lisa Marie Mac, Baevin Carbery, Robert T. Chen

NYMC Faculty Publications

The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) was formed to evaluate the safety of live, recombinant viral vaccines incorporating genes from heterologous viruses inserted into the backbone of another virus (so-called "chimeric virus vaccines"). Many viral vector vaccines are in advanced clinical trials. The first such vaccine to be approved for marketing (to date in Australia, Thailand, Malaysia, and the Philippines) is a vaccine against the flavivirus, Japanese encephalitis (JE), which employs a licensed vaccine (yellow fever 17D) as a vector. In this vaccine, two envelope proteins (prM-E) of YF 17D virus were exchanged for the corresponding …

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Distinct Signaling Mechanisms Of Mtorc1 And Mtorc2 In Glioblastoma Multiforme: A Tale Of Two Complexes, Meena Jhanwar-Uniyal, John L. Gillick, Jayson Neil, Michael Tobias, Zachary E. Thwing, Raj Murali Jan 2015

Distinct Signaling Mechanisms Of Mtorc1 And Mtorc2 In Glioblastoma Multiforme: A Tale Of Two Complexes, Meena Jhanwar-Uniyal, John L. Gillick, Jayson Neil, Michael Tobias, Zachary E. Thwing, Raj Murali

NYMC Faculty Publications

Mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that functions via two multiprotein complexes, namely mTORC1 and mTORC2, each characterized by different binding partners that confer separate functions. mTORC1 function is tightly regulated by PI3-K/Akt and is sensitive to rapamycin. mTORC2 is sensitive to growth factors, not nutrients, and is associated with rapamycin-insensitivity. mTORC1 regulates protein synthesis and cell growth through downstream molecules: 4E-BP1 (also called EIF4E-BP1) and S6K. Also, mTORC2 is thought to modulate growth factor signaling by phosphorylating the C-terminal hydrophobic motif of some AGC kinases such as Akt and SGK. Recent evidence has suggested that mTORC2 …

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Differential Proteomic Analysis Of Endemic And Sporadic Epstein-Barr Virus-Positive And Negative Burkitt Lymphoma, Nader Kim El-Mallawany, Nancy Day, Janet Ayello, Carmella Van De Ven, Kevin Conlon, Damian Fermin, Venkatesha Basrur, Kojo Elenitoba-Johnson, Megan Lim, Mitchell S. Cairo Jan 2015

Differential Proteomic Analysis Of Endemic And Sporadic Epstein-Barr Virus-Positive And Negative Burkitt Lymphoma, Nader Kim El-Mallawany, Nancy Day, Janet Ayello, Carmella Van De Ven, Kevin Conlon, Damian Fermin, Venkatesha Basrur, Kojo Elenitoba-Johnson, Megan Lim, Mitchell S. Cairo

NYMC Faculty Publications

BACKGROUND: Burkitt lymphoma (BL) is the most common non-Hodgkin lymphoma in children worldwide and the most common paediatric malignancy in sub-Saharan Africa. The endemic (eBL) and sporadic (sBL) variants have distinct epidemiologic and virologic characteristics. Although gene expression studies have defined the transcriptional profiles of both, their proteomic signatures have not been studied. METHODS: We compared the proteomic expression profiles using differential mass spectrometry-based isotope tag for relative and absolute quantitation (iTRAQ) analysis of a cell line representing Epstein-Barr virus (EBV)+ eBL, EBV+ and EBV- sBL, and EBV+/- normal B cells from healthy donors. RESULTS: In total, there were 144 …

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Androgen-Induced Hypertension In Angiotensinogen Deficient Mice: Role Of 20-Hete And Eets, Victor Garcia, Jennifer Cheng, Adam Weidenhammer, Yan Ding, Cheng-Chia Wu, Fan Zhang, Katherine Gotlinger, John R. Falck, Michal L. Schwartzman Jan 2015

Androgen-Induced Hypertension In Angiotensinogen Deficient Mice: Role Of 20-Hete And Eets, Victor Garcia, Jennifer Cheng, Adam Weidenhammer, Yan Ding, Cheng-Chia Wu, Fan Zhang, Katherine Gotlinger, John R. Falck, Michal L. Schwartzman

NYMC Faculty Publications

20-HETE is a potent inducer of endothelial ACE in vitro and administration of lisinopril or losartan attenuates blood pressure in models of 20-HETE-dependent hypertension. The present study was undertaken to further define the relationship between 20-HETE and the renin-angiotensin system in hypertension using an angiotensinogen-deficient mouse (Agt+/-). Treatment of male AGT+/- with 5α-dihydrotestosterone (DHT) increased systolic BP from 102±2 to 125±3mmHg; in comparison, the same treatment raised BP in wild type (WT) from 110±2 to 138±2mmHg. DHT increased vascular 20-HETE levels in AGT+/- and WT from 1.5±0.7 and 2.1±0.6 to 13.0±2.0 and 15.8±4.0ng/mg, respectively. Concurrent treatment with the 20-HETE antagonist, …

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Depressive Symptoms And Violence Exposure: Contributors To Repeat Pregnancies Among Adolescents, Cheryl Ann Anderson Jan 2015

Depressive Symptoms And Violence Exposure: Contributors To Repeat Pregnancies Among Adolescents, Cheryl Ann Anderson

Nursing Faculty Publications & Presentations - Archive

Depressive symptoms and violence exposure (VE) often cooccur and have been recognized to influence childbearing; contribution to repeat pregnancy is unclear and examined in this article. This cross-sectional, descriptive, study screened for depressive symptoms and VE among 193 adolescent mothers at a large county hospital in Southwestern United States. Repeat pregnancy and depressive symptoms characterized one-third and one-quarter of adolescents, respectively. Despite minimal disclosure of VE, repeat pregnancy was significantly influenced by child abuse and past traumatic life experiences. Assessments and interventions with adolescents should focus on frequency of repeat pregnancies and symptoms of depression and VE. Nurses and childbirth …

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A Narrative Analysis Of Women's Adaptation Following Sexual Assault, Debra Hurd Jan 2015

A Narrative Analysis Of Women's Adaptation Following Sexual Assault, Debra Hurd

Nursing Dissertations - Archive

Sexual assault against women violates every area of their lives: safety, security, physical health, and social status. Available evidence is inadequate to guide interventions to promote effective adaptation following assault. No studies have been found specifically on sexual assault of women from the perspective of the affected woman. The purpose of this study was to describe the narratives and coping strategies of women who have been sexually assaulted. The study questions and analysis were framed using Roy's Adaptation model. Narrative analysis was the research design used to examine stories of the women's experiences after sexual assault and how the women's …

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Measuring The Direct Nurses' And Nurse Leaders' Perceptions Of A Healthy Work Environment Within Acute Care Settings, Penny Susette Huddleston Jan 2015

Measuring The Direct Nurses' And Nurse Leaders' Perceptions Of A Healthy Work Environment Within Acute Care Settings, Penny Susette Huddleston

Nursing Dissertations - Archive

Healthy work environments (HWEs) have been described as policies, procedures, and processes designed to empower nurses to meet the organizational objectives and achieve personal satisfaction in the work environment (American Association of Critical-Care Nurses, 2005; Lake, 2007; Schmalenberg & Kramer, 2008; Shirey, 2006). Unhealthy work environments (UWEs) throughout healthcare organizations have been linked to absenteeism, ineffective delivery of healthcare to patients and families, higher stress levels, poor communication, and ineffective collaboration and teamwork among healthcare professionals (Heath, Johanson, & Blake, 2004). The American Association of Critical-Care Nurses (AACN) developed a Healthy Work Environment Assessment Tool (HWEAT) for nurses to use …

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Increasing Drug Screens And Prescription Drug Monitoring Program Assessments For Patients Enrolled In Opioid Replacement Therapy, Kimberly Thompson Jan 2015

Increasing Drug Screens And Prescription Drug Monitoring Program Assessments For Patients Enrolled In Opioid Replacement Therapy, Kimberly Thompson

Doctor of Nursing Practice (DNP) Scholarly Projects - Archive

Opioid use disorder is an epidemic that has a devastating impact on public health, morbidity and mortality, and the escalating economic burden of healthcare (U.S. Department of Health & Human Services, 2013). The rates of prescriptive and nonprescriptive opioid misuse are on the rise (Compton, Boyle, & Wargo, 2015). One approach in managing opioid use disorder is opioid replacement therapy (ORT). In response to increasing rates of opioid use disorder, the Drug Addiction Treatment Act of 2000 permitted "qualifying physicians" to treat opioid use disorder in an office-based setting. The FDA approved medication buprenorphine, a partial opioid agonist, is used …

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The Relationship Between Faith-Based Support And Physical Activity Levels Among African American Women In Faith Communities, Sharon Taylor Johnson Jan 2015

The Relationship Between Faith-Based Support And Physical Activity Levels Among African American Women In Faith Communities, Sharon Taylor Johnson

Nursing Dissertations - Archive

Physical inactivity is the fourth leading risk factor for death worldwide, and is a major contributor for a number of chronic diseases such as obesity, type 2 diabetes, hypertension, and cancer in the United States (CDC, 2014; World Health Organization, 2010). This public health problem is more prevalent among African American women who have been diagnosed with chronic health conditions and live sedentary lifestyles. Therefore, identifying strategies that contribute to improving physical activity levels are warranted for this population. The purpose of this study was to examine the relationship between participation in faith-based groups and physical activity levels among African …

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Promotion Of Advanced Practice Provider Compliance With The 2012 Surviving Sepsis Campaign Three-Hour Bundle Guidelines In The Emergency Department: A Multi-Component Intervention, Michael Watson Jan 2015

Promotion Of Advanced Practice Provider Compliance With The 2012 Surviving Sepsis Campaign Three-Hour Bundle Guidelines In The Emergency Department: A Multi-Component Intervention, Michael Watson

Doctor of Nursing Practice (DNP) Scholarly Projects - Archive

Refer to the document.

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The Effects Of Nutritional Status Assessment By Pre-Albumin Level And Its Effects On Functional Independence Measures (Fim) In Adult Patients After Fall And Fracture, Saeed Niyati Jan 2015

The Effects Of Nutritional Status Assessment By Pre-Albumin Level And Its Effects On Functional Independence Measures (Fim) In Adult Patients After Fall And Fracture, Saeed Niyati

Doctor of Nursing Practice (DNP) Scholarly Projects - Archive

Background: Fall is leading cause of injury in elderly persons. Nutritional status is an important aspect of elderly life that influences daily activities, quality of life in patients with fall and fractures. Objectives: To evaluate the effects of nutritional assessment by prealbumin level on Functional Independence Measures (FIM) and Length of Stay (LOS)in elderly population with fall and fracture in rehabilitation hospital. Methods: This study design was a one group pretest-posttest without a control group. Seventy one patients (n=71) 65 years or older who were admitted to the rehabilitation hospital with a diagnosis of fall and fracture recruited. Nutritional status …

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Mental Health Access Among International College Students, Linda Bett Jan 2015

Mental Health Access Among International College Students, Linda Bett

Doctor of Nursing Practice (DNP) Scholarly Projects - Archive

The International student population is steadily rising in various campuses across the United States (U.S). Mental health concerns such as mood, anxiety, adjustment disorders, relationship problems, and academic struggles are significant among this population (Mitchell, Greenwood, and Guglielmi, 2007; Yorgason, Linville, and Zitzman, 2008). Lack of knowledge, fear, stigma, poor support resources, unawareness of service availability, beliefs, culture, and mental health experiences have been voiced as reasons that impact help seeking attitudes. Early mental health interventions are therefore warranted; if mental health concerns are left unaddressed they could result in a decreased ability to function or more fatal consequences such …

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Interdisciplinary Teams In Healthcare: Can Geriatric Healthcare Be Improved?, Rebecca Notter, Sam Hadar Jan 2015

Interdisciplinary Teams In Healthcare: Can Geriatric Healthcare Be Improved?, Rebecca Notter, Sam Hadar

Honors Projects

No abstract provided.

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Colorectal Cancer Screening Practices Among Nurse Practitioners And Physician Assistants, Sandra A. Laird Jan 2015

Colorectal Cancer Screening Practices Among Nurse Practitioners And Physician Assistants, Sandra A. Laird

Doctor of Nursing Practice (DNP) Scholarly Projects - Archive

Purpose: The purpose of this study was to describe and compare the colorectal cancer screening practices of Texas nurse practitioners (NPs) and physician assistants (PAs). Research Questions: 1) What are the beliefs, attitudes, barriers, and practices of Texas NPs and P As with regard to risk stratified CRC screening in adults? 2) Is there a relationship between provider demographics (professional role, age, gender, race/ ethnicity, time in professional role, specialty, practice setting, percentage of primary care provided, percentage of patients aged>50, and weekly patient volume) and CRC screening practices? 3) What are the differences between NPs and P As …

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Bmx: A Tool For Computing Bacterial Phyletic Composition From Orthologous Maps, Benard W. Kulohoma Jan 2015

Bmx: A Tool For Computing Bacterial Phyletic Composition From Orthologous Maps, Benard W. Kulohoma

All Peer-Reviewed Publications

Background: New sequencing technologies have made it possible to explore genetic diversity at higher resolution in microbial populations. However, our understanding evolutionary relationships, and comparison of closely and distantly related bacterial genomes from these massive datasets remains a formidable challenge. Numerous clustering algorithms that group genomic data based on homology have been developed, but new tools are still required to analyse the resultant orthologous maps to understand functional genetic similarities and their phyletic patterns (patterns of presence of absence of genes). Findings: Bacterial Makeup eXplorer (BMX) implements an algorithm that swiftly and efficiently facilitates the determination of the number of …

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Population Genetics Of Two Key Mosquito Vectors Of Rift Valley Fever Virus Reveals New Insights Into The Changing Disease Outbreak Patterns In Kenya, David P. Tchouassi, Armanda D.S. Bastos, Catherine L. Sole, Mawlouth Diallo, Joel Lutomiah, James Mutisya, Francis Mulwa, Christian Borgemeister, Rosemary Sang, Baldwyn Torto Dec 2014

Population Genetics Of Two Key Mosquito Vectors Of Rift Valley Fever Virus Reveals New Insights Into The Changing Disease Outbreak Patterns In Kenya, David P. Tchouassi, Armanda D.S. Bastos, Catherine L. Sole, Mawlouth Diallo, Joel Lutomiah, James Mutisya, Francis Mulwa, Christian Borgemeister, Rosemary Sang, Baldwyn Torto

All Peer-Reviewed Publications

Rift Valley fever (RVF) outbreaks in Kenya have increased in frequency and range to include northeastern Kenya where viruses are increasingly being isolated from known (Aedes mcintoshi) and newly-associated (Ae. ochraceus) vectors. The factors contributing to these changing outbreak patterns are unclear and the population genetic structure of key vectors and/or specific virus-vector associations, in particular, are under-studied. By conducting mitochondrial and nuclear DNA analyses on >220 Kenyan specimens of Ae. mcintoshi and Ae. ochraceus, we uncovered high levels of vector complexity which may partly explain the disease outbreak pattern. Results indicate that Ae. mcintoshi consists of a species complex …

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Cyp2j2 Targeting To Endothelial Cells Attenuates Adiposity And Vascular Dysfunction In Mice Fed A High-Fat Diet By Reprogramming Adipocyte Phenotype, Nader G. Abraham, Komal Sodhi, Anne M. Silvis, Luca Vanella, Gaia Favero, Rita Rezzani, Craig Lee, Darryl C. Zeldin, Michal L. Schwartzman Dec 2014

Cyp2j2 Targeting To Endothelial Cells Attenuates Adiposity And Vascular Dysfunction In Mice Fed A High-Fat Diet By Reprogramming Adipocyte Phenotype, Nader G. Abraham, Komal Sodhi, Anne M. Silvis, Luca Vanella, Gaia Favero, Rita Rezzani, Craig Lee, Darryl C. Zeldin, Michal L. Schwartzman

NYMC Faculty Publications

Obesity is a global epidemic and a common risk factor for endothelial dysfunction and the subsequent development of diabetes mellitus and vascular diseases such as hypertension. Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP)-derived metabolites of arachidonic acid that contribute to vascular protection by stimulating vasodilation and inhibiting inflammation. Heme oxygenase-1 is a stress response protein that plays an important cytoprotective role against oxidative insult in diabetes mellitus and cardiovascular disease. We recently demonstrated interplay between EETs and heme oxygenase-1 in the attenuation of adipogenesis. We examined whether adipocyte dysfunction in mice fed a high-fat diet could be prevented by endothelial-specific …

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Advocating For Advocacy In Pediatrics: Supporting Lifelong Career Trajectories, Shetal I. Shah, Heather L. Brumberg Dec 2014

Advocating For Advocacy In Pediatrics: Supporting Lifelong Career Trajectories, Shetal I. Shah, Heather L. Brumberg

NYMC Faculty Publications

No abstract provided.

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Α-Ketoglutaramate: An Overlooked Metabolite Of Glutamine And A Biomarker For Hepatic Encephalopathy And Inborn Errors Of The Urea Cycle, Arthur J. Cooper, Tomiko Kuhara Dec 2014

Α-Ketoglutaramate: An Overlooked Metabolite Of Glutamine And A Biomarker For Hepatic Encephalopathy And Inborn Errors Of The Urea Cycle, Arthur J. Cooper, Tomiko Kuhara

NYMC Faculty Publications

Glutamine metabolism is generally regarded as proceeding via glutaminase-catalyzed hydrolysis to glutamate and ammonia, followed by conversion of glutamate to α-ketoglutarate catalyzed by glutamate dehydrogenase or by a glutamate-linked aminotransferase (transaminase). However, another pathway exists for the conversion of glutamine to α-ketoglutarate that is often overlooked, but is widely distributed in nature. This pathway, referred to as the glutaminase II pathway, consists of a glutamine transaminase coupled to ω-amidase. Transamination of glutamine results in formation of the corresponding α-keto acid, namely, α-ketoglutaramate (KGM). KGM is hydrolyzed by ω-amidase to α-ketoglutarate and ammonia. The net glutaminase II reaction is: L - …

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Phenylephrine Alteration Of Cerebral Blood Flow During Orthostasis: Effect On N-Back Performance In Chronic Fatigue Syndrome, Marvin S. Medow, Shilpa Sood, Zachary Messer, Seli Dzogbeta, Courtney Terilli, Julian M. Stewart Nov 2014

Phenylephrine Alteration Of Cerebral Blood Flow During Orthostasis: Effect On N-Back Performance In Chronic Fatigue Syndrome, Marvin S. Medow, Shilpa Sood, Zachary Messer, Seli Dzogbeta, Courtney Terilli, Julian M. Stewart

NYMC Faculty Publications

Chronic fatigue syndrome (CFS) with orthostatic intolerance is characterized by neurocognitive deficits and impaired working memory, concentration, and information processing. In CFS, upright tilting [head-up tilt (HUT)] caused decreased cerebral blood flow velocity (CBFv) related to hyperventilation/hypocapnia and impaired cerebral autoregulation; increasing orthostatic stress resulted in decreased neurocognition. We loaded the baroreflex with phenylephrine to prevent hyperventilation and performed n-back neurocognition testing in 11 control subjects and 15 CFS patients. HUT caused a significant increase in heart rate (109.4 ± 3.9 vs. 77.2 ± 1.6 beats/min, P < 0.05) and respiratory rate (20.9 ± 1.7 vs. 14.2 ± 1.2 breaths/min, P < 0.05) and decrease in end-tidal CO2 (ETCO2; 42.8 ± 1.2 vs. 33.9 ± 1.1 Torr, P < 0.05) in CFS vs. control. HUT caused CBFv to decrease 8.7% in control subjects but fell 22.5% in CFS. In CFS, phenylephrine prevented the HUT-induced hyperventilation/hypocapnia and the significant drop in CBFv with HUT (-8.1% vs. -22.5% untreated). There was no difference in control subject n-back normalized response time (nRT) comparing supine to HUT (106.1 ± 6.9 vs. 97.6 ± 7.1 ms at n = 4), and no difference comparing control to CFS while supine (97.1 ± 7.1 vs 96.5 ± 3.9 ms at n = 4). However, HUT of CFS subjects caused a significant increase in nRT (148.0 ± 9.3 vs. 96.4 ± 6.0 ms at n = 4) compared with supine. Phenylephrine significantly reduced the HUT-induced increase in nRT in CFS to levels similar to supine (114.6 ± 7.1 vs. 114.6 ± 9.3 ms at n = 4). Compared with control subjects, CFS subjects are more sensitive both to orthostatic challenge and to baroreflex/chemoreflex-mediated interventions. Increasing blood pressure with phenylephrine can alter CBFv. In CFS subjects, mitigation of the HUT-induced CBFv decrease with phenylephrine has a beneficial effect on n-back outcome.

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Kynurenine Aminotransferase Iii And Glutamine Transaminase L Are Identical Enzymes That Have Cysteine S-Conjugate Β-Lyase Activity And Can Transaminate L-Selenomethionine, John T. Pinto, Boris F. Krasnikov, Steven Alcutt, Melanie E. Jones, Thambi Dorai, Maria T. Villar, Antonio Artigues, Jianyong Li, Arthur J. Cooper Nov 2014

Kynurenine Aminotransferase Iii And Glutamine Transaminase L Are Identical Enzymes That Have Cysteine S-Conjugate Β-Lyase Activity And Can Transaminate L-Selenomethionine, John T. Pinto, Boris F. Krasnikov, Steven Alcutt, Melanie E. Jones, Thambi Dorai, Maria T. Villar, Antonio Artigues, Jianyong Li, Arthur J. Cooper

NYMC Faculty Publications

Three of the four kynurenine aminotransferases (KAT I, II, and IV) that synthesize kynurenic acid, a neuromodulator, are identical to glutamine transaminase K (GTK), α-aminoadipate aminotransferase, and mitochondrial aspartate aminotransferase, respectively. GTK/KAT I and aspartate aminotransferase/KAT IV possess cysteine S-conjugate β-lyase activity. The gene for the former enzyme, GTK/KAT I, is listed in mammalian genome data banks as CCBL1 (cysteine conjugate beta-lyase 1). Also listed, despite the fact that no β-lyase activity has been assigned to the encoded protein in the genome data bank, is a CCBL2 (synonym KAT III). We show that human KAT III/CCBL2 possesses cysteine S-conjugate β-lyase …

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Education And Training For Suicide Prevention In India, Amresh Srivastava Nov 2014

Education And Training For Suicide Prevention In India, Amresh Srivastava

Data and Test Instruments

No abstract provided.

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Occurrence Of Rift Valley Fever In Cattle In Ijara District, Kenya, Nelson O. Owange, William O. Ogara, Hippolyte Affognon, Gathura B. Peter, Jacqueline Kasiiti, Sam Okuthe, W. Onyango-Ouma, Tobias Landmann, Rosemary Sang, Murithi Mbabu Nov 2014

Occurrence Of Rift Valley Fever In Cattle In Ijara District, Kenya, Nelson O. Owange, William O. Ogara, Hippolyte Affognon, Gathura B. Peter, Jacqueline Kasiiti, Sam Okuthe, W. Onyango-Ouma, Tobias Landmann, Rosemary Sang, Murithi Mbabu

All Peer-Reviewed Publications

Ijara district in Kenya was one of the hotspots of rift valley fever (RVF) during the 2006/2007 outbreak which led to human and animal deaths causing huge economic and public health losses. The main constraint in the control and prevention of RVF is inadequate knowledge on its occurrence during the interepidemic period. This study was aimed at understanding the occurrence of RVF in cattle in Ijara to enable the development of improved community-based disease surveillance, prediction, control and prevention.Six herds each 700-1000 cattle were identified with participatory involvement of locals and project technical team of the project. One animal per …

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Permanent Pacemaker Utilization In Older Patients With Syncope And Carotid Sinus Syndrome, Sahil Khera, Dhaval Kolte, Sei Iwai, Chandrasekar Palaniswamy, Prakash Harikrishnan, Tanush Gupta, Marjan Mujib, Diwakar Jain, Howard A. Cooper, Wilbert S. Aronow, Gregg C. Fonarow, Julio A. Panza Oct 2014

Permanent Pacemaker Utilization In Older Patients With Syncope And Carotid Sinus Syndrome, Sahil Khera, Dhaval Kolte, Sei Iwai, Chandrasekar Palaniswamy, Prakash Harikrishnan, Tanush Gupta, Marjan Mujib, Diwakar Jain, Howard A. Cooper, Wilbert S. Aronow, Gregg C. Fonarow, Julio A. Panza

NYMC Faculty Publications

No abstract provided.

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Kcnj10 Is A Major Type Of K+ Channel In Mouse Corneal Epithelial Cells And Plays A Role In Initiating Egfr Signaling, Lijun Wang, Chengbiao Zhang, Xiaotong Su, Daohong Lin Oct 2014

Kcnj10 Is A Major Type Of K+ Channel In Mouse Corneal Epithelial Cells And Plays A Role In Initiating Egfr Signaling, Lijun Wang, Chengbiao Zhang, Xiaotong Su, Daohong Lin

NYMC Faculty Publications

We used primary mouse corneal epithelial cells (pMCE) to examine the role of Kcnj10 in determining membrane K(+) conductance and cell membrane potential and in regulating EGF/TGFA release. Western blot, immunostaining, and RT-PCR detected the expression of Kcnj10 in mouse cornea. The single channel recording identified the 20-pS inwardly rectifying K(+) channels in pMCE of WT mice, but these channels were absent in Kcnj10(-/-). Moreover, the whole cell recording demonstrates that deletion of Kcnj10 largely abolished the inward K(+) currents and depolarized the cell membrane K(+) reversal potential (an index of the cell membrane potential). This suggests that Kcnj10 is …

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Risk Groups For Yellow Fever Vaccine-Associated Viscerotropic Disease (Yel-Avd), Stephen J. Seligman Oct 2014

Risk Groups For Yellow Fever Vaccine-Associated Viscerotropic Disease (Yel-Avd), Stephen J. Seligman

NYMC Faculty Publications

Although previously considered as the safest of the live virus vaccines, reports published since 2001 indicate that live yellow fever virus vaccine can cause a severe, often fatal, multisystemic illness, yellow fever vaccine-associated viscerotropic disease (YEL-AVD), that resembles the disease it was designed to prevent. This review was prompted by the availability of a listing of the cumulative cases of YEL-AVD, insights from a statistical method for analyzing risk factors and re-evaluation of previously published data. The purpose of this review is to identify and analyze risk groups based on gender, age, outcome and predisposing illnesses. Using a passive surveillance …

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Partial Blockade Of Nicotinic Acetylcholine Receptors Improves The Counterregulatory Response To Hypoglycemia In Recurrently Hypoglycemic Rats, Edmund F. Lagamma, Necla Kirtok, Owen Chan, Bistra B. Nankova Oct 2014

Partial Blockade Of Nicotinic Acetylcholine Receptors Improves The Counterregulatory Response To Hypoglycemia In Recurrently Hypoglycemic Rats, Edmund F. Lagamma, Necla Kirtok, Owen Chan, Bistra B. Nankova

NYMC Faculty Publications

Recurrent exposure to hypoglycemia can impair the normal counterregulatory hormonal responses that guard against hypoglycemia, leading to hypoglycemia unawareness. This pathological condition known as hypoglycemia-associated autonomic failure (HAAF) is the main adverse consequence that prevents individuals with type 1 diabetes mellitus from attaining the long-term health benefits of tight glycemic control. The underlying molecular mechanisms responsible for the progressive loss of the epinephrine response to subsequent bouts of hypoglycemia, a hallmark sign of HAAF, are largely unknown. Normally, hypoglycemia triggers both the release and biosynthesis of epinephrine through activation of nicotinic acetylcholine receptors (nAChR) on the adrenal glands. We hypothesize …

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Downregulation Of Cox-2 And Cyp 4a Signaling By Isoliquiritigenin Inhibits Human Breast Cancer Metastasis Through Preventing Anoikis Resistance, Migration And Invasion, Hao Zheng, Ying Li, Yuzhong Wang, Haixia Zhao, Jing Zhang, Hongyan Chai, Tian Tang, Jiang Yue, Austin M. Guo, Jing Yang Oct 2014

Downregulation Of Cox-2 And Cyp 4a Signaling By Isoliquiritigenin Inhibits Human Breast Cancer Metastasis Through Preventing Anoikis Resistance, Migration And Invasion, Hao Zheng, Ying Li, Yuzhong Wang, Haixia Zhao, Jing Zhang, Hongyan Chai, Tian Tang, Jiang Yue, Austin M. Guo, Jing Yang

NYMC Faculty Publications

Flavonoids exert extensive in vitro anti-invasive and in vivo anti-metastatic activities. Anoikis resistance occurs at multiple key stages of the metastatic cascade. Here, we demonstrate that isoliquiritigenin (ISL), a flavonoid from Glycyrrhiza glabra, inhibits human breast cancer metastasis by preventing anoikis resistance, migration and invasion through downregulating cyclooxygenase (COX)-2 and cytochrome P450 (CYP) 4A signaling. ISL induced anoikis in MDA-MB-231 and BT-549 human breast cancer cells as evidenced by flow cytometry and the detection of caspase cleavage. Moreover, ISL inhibited the mRNA expression of phospholipase A2, COX-2 and CYP 4A and decreased the secretion of prostaglandin E2 (PGE2) and 20-hydroxyeicosatetraenoic …

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Decorin Binding Proteins A And B In The Serodiagnosis Of Lyme Disease In North America, Paul M. Arnaboldi, Mariya Sambir, Raymond J. Dattwyler Oct 2014

Decorin Binding Proteins A And B In The Serodiagnosis Of Lyme Disease In North America, Paul M. Arnaboldi, Mariya Sambir, Raymond J. Dattwyler

NYMC Faculty Publications

The laboratory diagnosis of Lyme disease is based upon the detection of antibodies generated against Borrelia burgdorferi using a two-tier assay, typically consisting of an enzyme-linked immunosorbent assay (ELISA), followed by a Western blot. This system, put into place to address the nonspecificity associated with standalone first-tier assays, is insensitive for diagnosing early infection, when most people seek care. The use of bacterial lysates or whole-protein antigens as first-tier assay targets contributes to nonspecificity due, in part, to the presence of cross-reactive epitopes that are also found in other bacteria. This precludes their use as sensitive standalone assays. The use …

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