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Articles 1681 - 1710 of 2038

Full-Text Articles in Medicine and Health Sciences

Combined Diazepam And Mk-801 Therapy Provides Synergistic Protection From Tetramethylenedisulfotetramine-Induced Tonic-Clonic Seizures And Lethality In Mice, Michael P. Shakarjian, Mahil S. Ali, Jana Velíšková, Patric K. Stanton, Diane E. Heck, Libor Velíšek May 2015

Combined Diazepam And Mk-801 Therapy Provides Synergistic Protection From Tetramethylenedisulfotetramine-Induced Tonic-Clonic Seizures And Lethality In Mice, Michael P. Shakarjian, Mahil S. Ali, Jana Velíšková, Patric K. Stanton, Diane E. Heck, Libor Velíšek

NYMC Faculty Publications

The synthetic rodenticide, tetramethylenedisulfotetramine (TMDT), is a persistent and highly lethal GABA-gated Cl(-) channel blocker. TMDT is clandestinely produced, remains popular in mainland China, and causes numerous unintentional and deliberate poisonings worldwide. TMDT is odorless, tasteless, and easy to manufacture, features that make it a potential weapon of terrorism. There is no effective treatment. We previously characterized the effects of TMDT in C57BL/6 mice and surveyed efficacies of GABAergic and glutamatergic anticonvulsant treatments. At 0.4 mg/kg i.p., TMDT produced neurotoxic symptomatology consisting of twitches, clonic and tonic-clonic seizures, often progressing to status epilepticus and death. If administered immediately after the …

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Breaking The Barriers: New Role For Insulin-Like Growth Factor 1 Receptor In Vascular Permeability, Sandhya Xavier May 2015

Breaking The Barriers: New Role For Insulin-Like Growth Factor 1 Receptor In Vascular Permeability, Sandhya Xavier

NYMC Faculty Publications

This commentary highlights the article by Liang et al that describes a critical role for insulin-like growth factor 1 receptor in the progression of chronic kidney disease.

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Azilsartan Is Associated With Increased Circulating Angiotensin-(1-7) Levels And Reduced Renovascular 20-Hete Levels, Mairéad A. Carroll, Younjung Kang, Praveen N. Chander, Charles T. Stier May 2015

Azilsartan Is Associated With Increased Circulating Angiotensin-(1-7) Levels And Reduced Renovascular 20-Hete Levels, Mairéad A. Carroll, Younjung Kang, Praveen N. Chander, Charles T. Stier

NYMC Faculty Publications

BACKGROUND: Activation of angiotensin (ANG) II type 1 receptors (AT1R) promotes vasoconstriction, inflammation, and renal dysfunction. In this study, we addressed the ability of azilsartan (AZL), a new AT1R antagonist, to modulate levels of plasma ANG-(1-7) and renal epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE). METHODS: Sprague-Dawley rats were infused with ANG II (125 ng/min) or vehicle (VEH). AZL (3 mg/kg/day) or VEH was administered starting 1 day prior to ANG II or VEH infusion. On day 10, plasma was obtained for measurement of ANG-(1-7) and kidneys for isolation of microvessels for EET and 20-HETE determination and histological evaluation. RESULTS: …

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Pharmacists In Primary Care, William H. Frishman May 2015

Pharmacists In Primary Care, William H. Frishman

NYMC Faculty Publications

No abstract provided.

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387. Gene Delivery Of Apoe2 Reduces Amyloid Pathology In Transgenic Mouse Models Of Alzheimer's Disease, Lingzhi Zhao, Andrew J. Gottesdiener, Mayur S. Parmar, Christine Grevstad, David Havlicek, Jonathan Rosenberg, Stephen Kaminsky, Maria Chiuchiolo, Dolan Sondhi, Ronald G. Crystal, Steven M. Paul May 2015

387. Gene Delivery Of Apoe2 Reduces Amyloid Pathology In Transgenic Mouse Models Of Alzheimer's Disease, Lingzhi Zhao, Andrew J. Gottesdiener, Mayur S. Parmar, Christine Grevstad, David Havlicek, Jonathan Rosenberg, Stephen Kaminsky, Maria Chiuchiolo, Dolan Sondhi, Ronald G. Crystal, Steven M. Paul

HPD Articles

The deposition of amyloid β-peptides (Aβ), cleavage products of the amyloid precursor protein (APP) by β- and γ-secretases, in brain represents a pathological hallmark of Alzheimer's disease (AD). Apolipoprotein E (APOE) ε4 allele carriers have an increased risk to develop AD and an earlier age of onset, whereas carriers of the ε2 allele have reduced risk and a delayed age of onset. APOE is also a major determinant of brain Aβ and amyloid burden in humans and in several transgenic mouse models of AD (E4>E3>E2). We have previously reported that lentivirus-mediated intraparenchymal gene delivery of APOE2 significantly reduces …

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Obesity Susceptibility Loci In Qataris, A Highly Consanguineous Arabian Population, Sara Tomei, Ravinder Mamtani, Rashid Al Ali, Naser Elkum, Maryam Abdulmalik, Awatef Ismail, Sohaila Cheema, Hekmat A. Rouh, Idil I. Aigha, Fatima Hani, Sura Al-Samraye, Mona Taher Aseel, Nada El Emadi, Azza Al Mujalli, Ahmed Abdelkerim, Siddik Youssif, Andrea Worschech, Emad El Sebakhy, Ramzi Temanni, Vineesh Khanna, Ena Wang, Dhanya Kizhakayil, Al-Anood Al-Thani, Mohammed Al-Thani, Albert Lowenfels, Francesco M. Marincola, Javaid Sheikh, Lotfi Chouchane Apr 2015

Obesity Susceptibility Loci In Qataris, A Highly Consanguineous Arabian Population, Sara Tomei, Ravinder Mamtani, Rashid Al Ali, Naser Elkum, Maryam Abdulmalik, Awatef Ismail, Sohaila Cheema, Hekmat A. Rouh, Idil I. Aigha, Fatima Hani, Sura Al-Samraye, Mona Taher Aseel, Nada El Emadi, Azza Al Mujalli, Ahmed Abdelkerim, Siddik Youssif, Andrea Worschech, Emad El Sebakhy, Ramzi Temanni, Vineesh Khanna, Ena Wang, Dhanya Kizhakayil, Al-Anood Al-Thani, Mohammed Al-Thani, Albert Lowenfels, Francesco M. Marincola, Javaid Sheikh, Lotfi Chouchane

NYMC Faculty Publications

OBJECTIVES: In Qataris, a population characterized by a small size and a high rate of consanguinity, between two-thirds to three-quarters of adults are overweight or obese. We investigated the relevance of 23 obesity-related loci in the Qatari population. METHODS: Eight-hundred-four individuals assessed to be third generation Qataris were included in the study and assigned to 3 groups according to their body mass index (BMI): 190 lean (BMI < 25 kg/m(2)); 131 overweight (25 kg/m(2) ≤ BMI < 30 kg/m(2)) and 483 obese (BMI ≥ 30 kg/m(2)). Genomic DNA was isolated from peripheral blood and genotyped by TaqMan. RESULTS: Two loci significantly associated with obesity in Qataris: the TFAP2B variation (rs987237) (A allele versus G allele: chi-square = 10.3; P = 0.0013) and GNPDA2 variation (rs10938397) (A allele versus G allele: chi-square = 6.15; P = 0.013). The TFAP2B GG genotype negatively associated with obesity (OR = 0.21; P = 0.0031). Conversely, the GNDPA2 GG homozygous genotype associated with higher risk of obesity in subjects of age < 32 years (P = 0.0358). CONCLUSION: We showed a different genetic profile associated with obesity in the Qatari population compared to Western populations. Studying the genetic background of Qataris is of primary importance as the etiology of a given disease might be population-specific.

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Src-Family Protein Tyrosine Kinase Phosphorylates Wnk4 And Modulates Its Inhibitory Effect On Kcnj1 (Romk), Dao-Hong Lin, Peng Yue, Orlando Yarborough, Ute I. Scholl, Gerhard Giebisch, Richard P. Lifton, Jesse Rinehart, Wen-Hui Wang Apr 2015

Src-Family Protein Tyrosine Kinase Phosphorylates Wnk4 And Modulates Its Inhibitory Effect On Kcnj1 (Romk), Dao-Hong Lin, Peng Yue, Orlando Yarborough, Ute I. Scholl, Gerhard Giebisch, Richard P. Lifton, Jesse Rinehart, Wen-Hui Wang

NYMC Faculty Publications

With-no-lysine kinase 4 (WNK4) inhibits the activity of the potassium channel KCNJ1 (ROMK) in the distal nephron, thereby contributing to the maintenance of potassium homeostasis. This effect is inhibited via phosphorylation at Ser1196 by serum/glucocorticoid-induced kinase 1 (SGK1), and this inhibition is attenuated by the Src-family protein tyrosine kinase (SFK). Using Western blot and mass spectrometry, we now identify three sites in WNK4 that are phosphorylated by c-Src: Tyr(1092), Tyr(1094), and Tyr(1143), and show that both c-Src and protein tyrosine phosphatase type 1D (PTP-1D) coimmunoprecipitate with WNK4. Mutation of Tyr(1092) or Tyr(1143) to phenylalanine decreased the association of c-Src or …

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Heme Biosynthesis Modulation Via Δ-Aminolevulinic Acid Administration Attenuates Chronic Hypoxia-Induced Pulmonary Hypertension, Raed Alhawaj, Dhara Patel, Melissa R. Kelly, Dong Sun, Michael S. Wolin Apr 2015

Heme Biosynthesis Modulation Via Δ-Aminolevulinic Acid Administration Attenuates Chronic Hypoxia-Induced Pulmonary Hypertension, Raed Alhawaj, Dhara Patel, Melissa R. Kelly, Dong Sun, Michael S. Wolin

NYMC Faculty Publications

This study examines how heme biosynthesis modulation with δ-aminolevulinic acid (ALA) potentially functions to prevent 21-day hypoxia (10% oxygen)-induced pulmonary hypertension in mice and the effects of 24-h organoid culture with bovine pulmonary arteries (BPA) with the hypoxia and pulmonary hypertension mediator endothelin-1 (ET-1), with a focus on changes in superoxide and regulation of micro-RNA 204 (miR204) expression by src kinase phosphorylation of signal transducer and activator of transcription-3 (STAT3). The treatment of mice with ALA attenuated pulmonary hypertension (assessed through echo Doppler flow of the pulmonary valve, and direct measurements of right ventricular systolic pressure and right ventricular hypertrophy), …

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Curtailing Endothelial Tgf-Β Signaling Is Sufficient To Reduce Endothelial-Mesenchymal Transition And Fibrosis In Ckd, Sandhya Xavier, Radovan Vasko, Kei Matsumoto, Joseph A. Zullo, Robert Chen, Julien Maizel, Praveen N. Chander, Michael S. Goligorsky Apr 2015

Curtailing Endothelial Tgf-Β Signaling Is Sufficient To Reduce Endothelial-Mesenchymal Transition And Fibrosis In Ckd, Sandhya Xavier, Radovan Vasko, Kei Matsumoto, Joseph A. Zullo, Robert Chen, Julien Maizel, Praveen N. Chander, Michael S. Goligorsky

NYMC Faculty Publications

Excessive TGF-β signaling in epithelial cells, pericytes, or fibroblasts has been implicated in CKD. This list has recently been joined by endothelial cells (ECs) undergoing mesenchymal transition. Although several studies focused on the effects of ablating epithelial or fibroblast TGF-β signaling on development of fibrosis, there is a lack of information on ablating TGF-β signaling in the endothelium because this ablation causes embryonic lethality. We generated endothelium-specific heterozygous TGF-β receptor knockout (TβRII(endo+/-)) mice to explore whether curtailed TGF-β signaling significantly modifies nephrosclerosis. These mice developed normally, but showed enhanced angiogenic potential compared with TβRII(endo+/+) mice under basal conditions. After induction …

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Accuracy Of Optic Nerve Sheath Diameter Measurement By Emergency Physicians Using Bedside Ultrasound, Getaw Worku Hassen, Isaac Bruck, Joseph Donahue, Benjamin Mason, Brett Sweeney, Weafue Saab, Jeremy Weedon, Neal Patel, Kenneth Perry, Hussein Matari, Rajnish Jaiswal, Hossein Kalantari Apr 2015

Accuracy Of Optic Nerve Sheath Diameter Measurement By Emergency Physicians Using Bedside Ultrasound, Getaw Worku Hassen, Isaac Bruck, Joseph Donahue, Benjamin Mason, Brett Sweeney, Weafue Saab, Jeremy Weedon, Neal Patel, Kenneth Perry, Hussein Matari, Rajnish Jaiswal, Hossein Kalantari

NYMC Faculty Publications

BACKGROUND: Ultrasound (US) measurement of the optic nerve sheath diameter (ONSD) has been utilized as an indirect assessment of intracranial pressure. It is usually performed by trained ultrasonographers. OBJECTIVES: To evaluate whether or not emergency physicians (EP) are capable of measuring the ONSD accurately by US. MATERIALS AND METHODS: A retrospective measurement of ONSD was conducted on computed tomography (CT) scans of the head or facial bones. These patients had undergone ocular US performed by EPs prior to CT scanning. The CT scan measurements of ONSD read by a board-certified radiologist were compared with that of the US read by …

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Targeting Cd20+ Aggressive B-Cell Non-Hodgkin Lymphoma By Anti-Cd20 Car Mrna-Modified Expanded Natural Killer Cells In Vitro And In Nsg Mice, Yaya Chu, Jessica Hochberg, Ashlin Yahr, Janet Ayello, Carmella Van De Ven, Matthew Barth, Myron Czuczman, Mitchell S. Cairo Apr 2015

Targeting Cd20+ Aggressive B-Cell Non-Hodgkin Lymphoma By Anti-Cd20 Car Mrna-Modified Expanded Natural Killer Cells In Vitro And In Nsg Mice, Yaya Chu, Jessica Hochberg, Ashlin Yahr, Janet Ayello, Carmella Van De Ven, Matthew Barth, Myron Czuczman, Mitchell S. Cairo

NYMC Faculty Publications

The prognosis is very dismal for patients with relapsed CD20(+) B-cell non-Hodgkin lymphoma (B-NHL). Facilitating the development of alternative novel therapeutic strategies is required to improve outcomes in patients with recurrent/refractory CD20(+) B-NHL. In this study, we investigated functional activities of anti-CD20 CAR-modified, expanded peripheral blood NK cells (exPBNK) following mRNA nucleofection against CD20(+) B-NHL in vitro and in vivo. CAR(+) exPBNK had significantly enhanced in vitro cytotoxicity, compared with CAR(-) exPBNK against CD20(+) Ramos (P < 0.05), Daudi, Raji, and two rituximab-resistant cell lines, Raji-2R and Raji-4RH (P < 0.001). As expected, there was no significant difference against CD20(-) RS4;11 and Jurkat cells. CD107a degranulation and intracellular IFNγ production were also enhanced in CAR(+) exPBNK in response to CD20(+) B-NHL -: specific stimulation. In Raji-Luc and Raji-2R-Luc xenografted NOD/SCID/γ-chain(-/-) (NSG) mice, the luciferase signals measured in the CAR(+) exPBNK-treated group were significantly reduced, compared with the signals measured in the untreated mice and in mice treated with the CAR(-) exPBNK. Furthermore, the CAR exPBNK-treated mice had significantly extended survival time (P < 0.001) and reduced tumor size, compared with those of the untreated and the CAR(-) exPBNK-treated mice (P < 0.05). These preclinical data suggest that ex vivo-exPBNK modified with anti-CD20 CAR may have therapeutic potential for treating patients with poor-risk CD20(+) hematologic malignancies.

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Utilization Of A Real-Time Pcr Assay For Diagnosis Of Babesia Microti Infection In Clinical Practice, Guiqing Wang, Gary P. Wormser, Jian Zhuge, Patrick Villafuerte, Dawn Ip, Christine Zeren, John T. Fallon Apr 2015

Utilization Of A Real-Time Pcr Assay For Diagnosis Of Babesia Microti Infection In Clinical Practice, Guiqing Wang, Gary P. Wormser, Jian Zhuge, Patrick Villafuerte, Dawn Ip, Christine Zeren, John T. Fallon

NYMC Faculty Publications

Babesiosis is an emerging tick-borne disease mainly caused Babesia microti, a protozoan that infects erythrocytes. Microscopic examination of blood smears is the current gold standard for detection of Babesia infection, but this diagnostic test has several limitations. We developed and assessed the clinical utilization of a multiplex real-time PCR assay targeting the 18S rRNA gene of B. microti and the human gapdh gene. The limit of detection of this PCR assay was approximately 1-3parasites/μl of blood. The assay showed a diagnostic sensitivity and probable specificity of 100% based on testing 145 retrospective and 185 prospective blood specimens from controls and …

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Review Article: Sociocultural And Economic Dimensions Of Rift Valley Fever, Geoffrey Otieno Muga, Washington Onyango-Ouma, Rosemary Sang, Hippolyte Affognon Apr 2015

Review Article: Sociocultural And Economic Dimensions Of Rift Valley Fever, Geoffrey Otieno Muga, Washington Onyango-Ouma, Rosemary Sang, Hippolyte Affognon

All Peer-Reviewed Publications

Health researchers have advocated for a cross-disciplinary approach to the study and prevention of infectious zoonotic diseases, such as Rift Valley Fever. It is believed that this approach can help bring out the social determinants and effects of the zoonotic diseases for the design of appropriate interventions and public health policy. A comprehensive literature review using a systematic search strategy was undertaken to explore the sociocultural and economic factors that influence the transmission and spread of Rift Valley Fever. Although the findings reveal a paucity of social research on Rift Valley Fever, they suggest that livestock sacrificial rituals, food preparation …

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Pass Quantity, Focus On Quality, Delong Liu, Weijing Sun, Jingzhou Hou, Ruirong Yuan, Zihai Li Mar 2015

Pass Quantity, Focus On Quality, Delong Liu, Weijing Sun, Jingzhou Hou, Ruirong Yuan, Zihai Li

NYMC Faculty Publications

Journal of Hematology & Oncology is pleased to see the exponential growth in the number of publications from China, especially in hematology and oncology. This editorial calls for putting more weight on the quality of the future scientific output and invites rigorous dialogs among policy makers, granting agencies, academic leaders, physicians, and scientists, followed by concrete actions, to achieve such a goal.

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Regulation Of Nonclassical Renin-Angiotensin System Receptor Gene Expression In The Adrenal Medulla By Acute And Repeated Immobilization Stress, Regina Nostramo, Lidia Serova, Marcela Laukova, Andrej Tillinger, Chandana Peddu, Esther L. Sabban Mar 2015

Regulation Of Nonclassical Renin-Angiotensin System Receptor Gene Expression In The Adrenal Medulla By Acute And Repeated Immobilization Stress, Regina Nostramo, Lidia Serova, Marcela Laukova, Andrej Tillinger, Chandana Peddu, Esther L. Sabban

NYMC Faculty Publications

The involvement of the nonclassical renin-angiotensin system (RAS) in the adrenomedullary response to stress is unclear. Therefore, we examined basal and immobilization stress (IMO)-triggered changes in gene expression of the classical and nonclassical RAS receptors in the rat adrenal medulla, specifically the angiotensin II type 2 (AT2) and type 4 (AT4) receptors, (pro)renin receptor [(P)RR], and Mas receptor (MasR). All RAS receptors were identified, with AT2 receptor mRNA levels being the most abundant, followed by the (P)RR, AT1A receptor, AT4 receptor, and MasR. Following a single IMO, AT2 and AT4 receptor mRNA levels decreased by 90 and 50%, respectively. Their …

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Blood Transfusion And Colorectal Cancer Outcome, Christina Jenkins, Albert B. Lowenfels Mar 2015

Blood Transfusion And Colorectal Cancer Outcome, Christina Jenkins, Albert B. Lowenfels

NYMC Faculty Publications

No abstract provided.

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Oscillatory Cerebral Blood Flow Is Associated With Impaired Neurocognition And Functional Hyperemia In Postural Tachycardia Syndrome During Graded Tilt, Julian M. Stewart, Andrew T. Del Pozzi, Akash Pandey, Zachary R. Messer, Courtney Terilli, Marvin S. Medow Mar 2015

Oscillatory Cerebral Blood Flow Is Associated With Impaired Neurocognition And Functional Hyperemia In Postural Tachycardia Syndrome During Graded Tilt, Julian M. Stewart, Andrew T. Del Pozzi, Akash Pandey, Zachary R. Messer, Courtney Terilli, Marvin S. Medow

NYMC Faculty Publications

We hypothesize that upright cognitive impairment in patients with postural tachycardia syndrome (POTS) is caused by reduced cerebral blood flow (CBF). The CBF velocity (CBF(v)) measured by transcranial Doppler ultrasound decreased excessively during 70° tilt in a minority of patients with intermittent hyperpnea/hypocapnia. Incremental tilt showed no difference in mean CBF(v). But N-back memory tasking indicated progressive compromised memory, reduced functional hyperemia, and reduced neurovascular coupling. Orthostasis caused slow oscillations in CBF(v) linked to oscillations in arterial pressure in patients with POTS. We also hypothesize that oscillatory CBF(v) degrades neurovascular coupling. We performed 2-back testing when subjects were in supine …

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Solving A Novel Confinement Problem By Spartaeine Salticids That Are Predisposed To Solve Problems In The Context Of Predation, Fiona R. Cross, Robert R. Jackson Mar 2015

Solving A Novel Confinement Problem By Spartaeine Salticids That Are Predisposed To Solve Problems In The Context Of Predation, Fiona R. Cross, Robert R. Jackson

All Peer-Reviewed Publications

Intricate predatory strategies are widespread in the salticid subfamily Spartaeinae. The hypothesis we consider here is that the spartaeine species that are proficient at solving prey-capture problems are also proficient at solving novel problems. We used nine species from this subfamily in our experiments. Eight of these species (two Brettus, one Cocalus, three Cyrba, two Portia) are known for specialized invasion of other spiders’ webs and for actively choosing other spiders as preferred prey (‘araneophagy’). Except for Cocalus, these species also use trial and error to derive web-based signals with which they gain dynamic fine control of the resident spider’s …

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Novel Alk Inhibitors In Clinical Use And Development, Chaitanya Iragavarapu, Milaim Mustafa, Akintunde Akinleye, Muhammad Furqan, Varun Mittal, Shundong Cang, Delong Liu Feb 2015

Novel Alk Inhibitors In Clinical Use And Development, Chaitanya Iragavarapu, Milaim Mustafa, Akintunde Akinleye, Muhammad Furqan, Varun Mittal, Shundong Cang, Delong Liu

NYMC Faculty Publications

Anaplastic lymphoma kinase 1 (ALK-1) is a member of the insulin receptor tyrosine kinase family. ALK-1 was initially found in anaplastic large cell lymphoma (ALCL). ALK mutations have also been implicated in the pathogenesis of non-small cell lung cancer (NSCLC) and other solid tumors. Multiple small molecule inhibitors with activity against ALK and related oncoproteins are under clinical development. Two of them, crizotinib and ceritinib, have been approved by FDA for treatment of locally advanced and metastatic NSCLC. More agents (alectinib, ASP3026, X396) with improved safety, selectivity, and potency are in the pipeline. Dual inhibitors targeting ALK and EGFRm (AP26113), …

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Development Of High Yield Reassortants For Influenza Type B Viruses And Analysis Of Their Gene Compositions, Jianhua Le, Edward J. Orff, Andrew A. Fulvini, Liling Huang, Shiroh Onodera, Barbara A. Pokorny, Andrew Malewicz, Patricia Primakov, Doris J. Bucher Feb 2015

Development Of High Yield Reassortants For Influenza Type B Viruses And Analysis Of Their Gene Compositions, Jianhua Le, Edward J. Orff, Andrew A. Fulvini, Liling Huang, Shiroh Onodera, Barbara A. Pokorny, Andrew Malewicz, Patricia Primakov, Doris J. Bucher

NYMC Faculty Publications

A critical step in producing the annual inactivated influenza vaccine is the development of high yield (hy) seed viruses by reassortment for improved growth in ovo. Although hy reassortants for type A influenza viruses have been developed for many years, hy B influenza reassortant virus development for vaccine production has proven difficult. In this study, we have developed fourteen hy influenza type B reassortants as vaccine candidate strains with B/Lee/40 as the donor virus. Upon characterization by the Influenza Division at the Centers for Disease Control and Prevention (CDC) and the verification of HA by sequencing, all B reassortants were …

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Access Disparity And Health Inequality Of The Elderly: Unmet Needs And Delayed Healthcare, Tetsuji Yamada, Chia-Ching Chen, Chiyoe Murata, Hiroshi Hirai, Toshiyuki Ojima, Katsunori Kondo, Joseph R. Harris Feb 2015

Access Disparity And Health Inequality Of The Elderly: Unmet Needs And Delayed Healthcare, Tetsuji Yamada, Chia-Ching Chen, Chiyoe Murata, Hiroshi Hirai, Toshiyuki Ojima, Katsunori Kondo, Joseph R. Harris

NYMC Faculty Publications

The purpose of this study is to investigate healthcare access disparity that will cause delayed and unmet healthcare needs for the elderly, and to examine health inequality and healthcare cost burden for the elderly. To produce clear policy applications, this study adapts a modified PRECEDE-PROCEED model for framing theoretical and experimental approaches. Data were collected from a large collection of the Community Tracking Study Household Survey 2003-2004 of the USA. Reliability and construct validity are examined for internal consistency and estimation of disparity and inequality are analyzed by using probit/ols regressions. The results show that predisposing factors (e.g., attitude, beliefs, …

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What Is New In Exercise In Pregnancy? Best Articles From The Past Year, Howard A. Blanchette Feb 2015

What Is New In Exercise In Pregnancy? Best Articles From The Past Year, Howard A. Blanchette

NYMC Faculty Publications

This month we focus on current research in exercise in pregnancy. Dr. Blanchette discusses four recent publications, and each is concluded with a "bottom line" that is the take-home message. The complete reference for each can be found in on this page, along with direct links to the abstracts.

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Induction Of Indoleamine 2,3-Dioxygenase By Borrelia Burgdorferi In Human Immune Cells Correlates With Pathogenic Potential, Andrea C. Love, Ira Schwartz, Mary M. Petzke Feb 2015

Induction Of Indoleamine 2,3-Dioxygenase By Borrelia Burgdorferi In Human Immune Cells Correlates With Pathogenic Potential, Andrea C. Love, Ira Schwartz, Mary M. Petzke

NYMC Faculty Publications

Borrelia burgdorferi, the bacterial agent of Lyme disease, induces the production of type I IFNs by human DCs through TLR7 and TLR9 signaling. This type I IFN response occurs in a genotype-dependent manner, with significantly higher levels of IFN-α elicited by B. burgdorferi strains that have a greater capacity for causing disseminated infection. A B. burgdorferi strain that was previously shown to induce IFN-α was found to elicit significantly higher levels of IDO1 protein and its downstream metabolite, kynurenine, compared with a B. burgdorferi mutant that lacks a single linear plasmid (lp36); this mutant is unable to induce IFN-α and …

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Long-Term Assessment Of Fatigue In Patients With Culture-Confirmed Lyme Disease, Gary P. Wormser, Erica Weitzner, Donna Mckenna, Robert B. Nadelman, Carol Scavarda, John Nowakowski Feb 2015

Long-Term Assessment Of Fatigue In Patients With Culture-Confirmed Lyme Disease, Gary P. Wormser, Erica Weitzner, Donna Mckenna, Robert B. Nadelman, Carol Scavarda, John Nowakowski

NYMC Faculty Publications

BACKGROUND: Fatigue is a common symptom with numerous causes. Severe fatigue is thought to be an important manifestation of post-treatment Lyme disease syndrome. The frequency with which severe fatigue occurs as a long-term sequela in prospectively followed patients with Lyme disease is unknown. METHODS: Patients with culture-confirmed Lyme disease who originally presented with erythema migrans have been evaluated annually in a prospective study to determine their long-term outcome. In 2011-2013, subjects were evaluated for fatigue using an 11-item Fatigue Severity Scale (FSS-11) that has been used in studies of post-treatment Lyme disease syndrome. An FSS-11 score of ≥4.0 is indicative …

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Microrna-146a And Microrna-146b Regulate Human Dendritic Cell Apoptosis And Cytokine Production By Targeting Traf6 And Irak1 Proteins, Haein Park, Xin Huang, Changming Lu, Mitchell S. Cairo, Xianzheng Zhou Jan 2015

Microrna-146a And Microrna-146b Regulate Human Dendritic Cell Apoptosis And Cytokine Production By Targeting Traf6 And Irak1 Proteins, Haein Park, Xin Huang, Changming Lu, Mitchell S. Cairo, Xianzheng Zhou

NYMC Faculty Publications

We have previously reported 27 differentially expressed microRNAs (miRNAs) during human monocyte differentiation into immature dendritic cells (imDCs) and mature DCs (mDCs). However, their roles in DC differentiation and function remain largely elusive. Here, we report that microRNA (miR)-146a and miR-146b modulate DC apoptosis and cytokine production. Expression of miR-146a and miR-146b was significantly increased upon monocyte differentiation into imDCs and mDCs. Silencing of miR-146a and/or miR-146b in imDCs and mDCs significantly prevented DC apoptosis, whereas overexpressing miR-146a and/or miR-146b increased DC apoptosis. miR-146a and miR-146b expression in imDCs and mDCs was inversely correlated with TRAF6 and IRAK1 expression. Furthermore, …

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Role Of Homocysteinylation Of Ace In Endothelial Dysfunction Of Arteries, An Huang, John T. Pinto, Ghezal Froogh, Sharath Kandhi, Jun Qin, Michael S. Wolin, Thomas H. Hintze, Dong Sun Jan 2015

Role Of Homocysteinylation Of Ace In Endothelial Dysfunction Of Arteries, An Huang, John T. Pinto, Ghezal Froogh, Sharath Kandhi, Jun Qin, Michael S. Wolin, Thomas H. Hintze, Dong Sun

NYMC Faculty Publications

The direct impact of de novo synthesis of homocysteine (Hcy) and its reactive metabolites, Hcy-S-S-Hcy and Hcy thiolactone (HCTL), on vascular function has not been fully elucidated. We hypothesized that Hcy synthesized within endothelial cells affects activity of angiotensin-converting enzyme (ACE) by direct homocysteinylation of its amino- and/or sulfhydryl moieties. This covalent modification enhances ACE reactivity toward angiotensin II (ANG II)-NADPH oxidase-superoxide-dependent endothelial dysfunction. Mesenteric and coronary arteries isolated from normal rats were incubated for 3 days with or without exogenous methionine (Met, 0.1-0.3 mM), a precursor to Hcy. Incubation of arteries in Met-free media resulted in time-dependent decreases in …

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Comparison Of Ankle Taping And Bracing On Ankle Biomechanics During Landing In Functional Ankle Instability, M. H. Ulm, B. A. Windsor, G. S. Dedrick, D. W. Powell Jan 2015

Comparison Of Ankle Taping And Bracing On Ankle Biomechanics During Landing In Functional Ankle Instability, M. H. Ulm, B. A. Windsor, G. S. Dedrick, D. W. Powell

Physical Therapy

No abstract provided.

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Antiarrhythmic Properties Of Ranolazine: A Review Of The Current Evidence, Tanush Gupta, Sahil Khera, Dhaval Kolte, Wilbert S. Aronow, Sei Iwai Jan 2015

Antiarrhythmic Properties Of Ranolazine: A Review Of The Current Evidence, Tanush Gupta, Sahil Khera, Dhaval Kolte, Wilbert S. Aronow, Sei Iwai

NYMC Faculty Publications

Ranolazine was developed as an antianginal agent and was approved by the Food and Drug Administration in 2006 for use in chronic stable angina pectoris. Experimental and clinical studies have shown that it also has antiarrhythmic properties based on the frequency-dependent blockade of peak sodium channel current (peak INa) and rapidly activating delayed rectifier potassium current (IKr) in the atria and blockade of late phase of the inward sodium current (late INa) in the ventricles. Recent clinical studies have revealed the efficacy of ranolazine in prevention of atrial fibrillation in patients with acute coronary syndromes, prevention as well as conversion …

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Agonists Of Epoxyeicosatrienoic Acids Reduce Infarct Size And Ameliorate Cardiac Dysfunction Via Activation Of Ho-1 And Wnt1 Canonical Pathway, Jian Cao, Peter L. Tsenovoy, Ellen A. Thompson, John R. Falck, Robert Touchon, Komal Sodhi, Rita Rezzani, Joseph I. Shapiro, Nader G. Abraham Jan 2015

Agonists Of Epoxyeicosatrienoic Acids Reduce Infarct Size And Ameliorate Cardiac Dysfunction Via Activation Of Ho-1 And Wnt1 Canonical Pathway, Jian Cao, Peter L. Tsenovoy, Ellen A. Thompson, John R. Falck, Robert Touchon, Komal Sodhi, Rita Rezzani, Joseph I. Shapiro, Nader G. Abraham

NYMC Faculty Publications

Myocardial infarction (MI) is complicated by ventricular fibrosis and associated diastolic and systolic failure. Emerging studies implicate Wnt1 signaling in the formation of new blood vessels. Epoxyeicosatrienoic acids (EETs)-mediated up-regulation of heme oxygenase-1 (HO-1) protects against the detrimental consequences of MI in several animal models, however, the mechanism(s) by which this occurs remains unclear. The aim of this study was to examine these mechanisms in the LAD ligation animal model of post infarcted heart failure. Specifically, we sought to clarify the mechanistic basis of the interactions of the Wnt1 canonical pathway, HO-1 and associated angiogenesis. Human microvascular endothelial cells (HMECs) …

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Heme Oxygenase-2 Deletion Impairs Macrophage Function: Implication In Wound Healing, Lars Bellner, Giuseppina Marrazzo, Nico Van Rooijen, Michael W. Dunn, Nader G. Abraham, Michal L. Schwartzman Jan 2015

Heme Oxygenase-2 Deletion Impairs Macrophage Function: Implication In Wound Healing, Lars Bellner, Giuseppina Marrazzo, Nico Van Rooijen, Michael W. Dunn, Nader G. Abraham, Michal L. Schwartzman

NYMC Faculty Publications

Heme oxygenase (HO)-2 deficiency impairs wound healing and exacerbates inflammation following injury. We examine the impact of HO-2 deficiency on macrophage function and the contribution of macrophage HO-2 to inflammatory and repair responses to injury. Corneal epithelial debridement was performed in control and macrophage-depleted HO-2(-/-) and wild-type (WT) mice and in bone marrow chimeras. Peritoneal macrophages were collected for determination of phagocytic activity and classically activated macrophage (M1)-alternatively activated macrophage (M2) polarization. Depletion of macrophages delayed corneal healing (13.2%) and increased neutrophil infiltration (54.1%) by day 4 in WT mice, whereas in HO-2(-/-) mice, it did not worsen the already …

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