Medicine and Health Sciences Commons^™

Developing Real-Time, Online Beam Control Of Uhdr Irradiators To Facilitate Flash Translational Investigations, Austin M. Sloop

Dartmouth College Ph.D Dissertations

The field of radiation oncology seeks novel techniques to increase the therapeutic ratio to treat malignancies while minimizing damage and toxicities in healthy tissues. While it was observed that delivering therapeutic doses at high dose rate could elicit lower biological effects over a half-century ago, the field of ultra-high dose rate (UHDR) radiation therapy (colloquially known as FLASH RT) has seen a resurgence in recent years due to an alignment of accelerator capability, dosimetric advances, and improved biotechnological techniques. This has opened the door to studying potential underlying mechanisms such that we may leverage the effects of FLASH tissue sparing …

Scproatlas: An Atlas Of Multiplexed Single-Cell Spatial Proteomics Imaging In Human Tissues, Tiangang Wang, Xuanmin Chen, Yujuan Han, Jiahao Yi, Xi Liu, Pora Kim, Liyu Huang, Kexin Huang, Xiaobo Zhou

Faculty, Staff and Student Publications

Spatial proteomics can visualize and quantify protein expression profiles within tissues at single-cell resolution. Although spatial proteomics can only detect a limited number of proteins compared to spatial transcriptomics, it provides comprehensive spatial information with single-cell resolution. By studying the spatial distribution of cells, we can clearly obtain the spatial context within tissues at multiple scales. Spatial context includes the spatial composition of cell types, the distribution of functional structures, and the spatial communication between functional regions, all of which are crucial for the patterns of cellular distribution. Here, we constructed a comprehensive spatial proteomics functional annotation knowledgebase, scProAtlas (https://relab.xidian.edu.cn/scProAtlas/#/), …

Aspdb: An Integrative Knowledgebase Of Human Protein Isoforms From Experimental And Ai-Predicted Structures, Yuntao Yang, Himansu Kumar, Yuhan Xie, Zhao Li, Rongbin Li, Wenbo Chen, Chiamaka S Diala, Meer A Ali, Yi Xu, Albon Wu, Sayed-Rzgar Hosseini, Erfei Bi, Hongyu Zhao, Pora Kim, W Jim Zheng

Faculty, Staff and Student Publications

Alternative splicing is a crucial cellular process in eukaryotes, enabling the generation of multiple protein isoforms with diverse functions from a single gene. To better understand the impact of alternative splicing on protein structures, protein-protein interaction and human diseases, we developed ASpdb (https://biodataai.uth.edu/ASpdb/), a comprehensive database integrating experimentally determined structures and AlphaFold 2-predicted models for human protein isoforms. ASpdb includes over 3400 canonical isoforms, each represented by both experimentally resolved and predicted structures, and >7200 alternative isoforms with AlphaFold 2 predictions. In addition to detailed splicing events, 3D structures, sequence variations and functional annotations, ASpdb uniquely offers comparative analyses and …

Metsdb: A Knowledgebase Of Cancer Metastasis At Bulk, Single-Cell And Spatial Levels, Sijia Wu, Jiajin Zhang, Yanfei Wang, Xinyu Qin, Zhaocan Zhang, Zhennan Lu, Pora Kim, Xiaobo Zhou, Liyu Huang

Faculty, Staff and Student Publications

Cancer metastasis, the process by which tumour cells migrate and colonize distant organs from a primary site, is responsible for the majority of cancer-related deaths. Understanding the cellular and molecular mechanisms underlying this complex process is essential for developing effective metastasis prevention and therapy strategies. To this end, we systematically analysed 1786 bulk tissue samples from 13 cancer types, 988 463 single cells from 17 cancer types, and 40 252 spots from 45 spatial slides across 10 cancer types. The results of these analyses are compiled in the metsDB database, accessible at https://relab.xidian.edu.cn/metsDB/. This database provides insights into alterations in …

Crisprofft: Comprehensive Database Of Crispr/Cas Off-Targets, Grant Wang, Xiaona Liu, Aoqi Wang, Jianguo Wen, Pora Kim, Qianqian Song, Xiaona Liu, Xiaobo Zhou

Faculty, Staff and Student Publications

The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas (CRISPR-associated protein) programmable nuclease system continues to evolve, with in vivo therapeutic gene editing increasingly applied in clinical settings. However, off-target effects remain a significant challenge, hindering its broader clinical application. To enhance the development of gene-editing therapies and the accuracy of prediction algorithms, we developed CRISPRoffT (https://ccsm.uth.edu/CRISPRoffT/). Users can access a comprehensive repository of off-target regions predicted and validated by a diverse range of technologies across various cell lines, Cas enzyme variants, engineered sgRNAs (single guide RNAs) and CRISPR editing systems. CRISPRoffT integrates results of off-target analysis from 74 studies, encompassing …

Autoethnographic Action Research As A Contemplative Practice: Awareness And Transformation Of Inner And Outer Selves, Jiju Varghese, Bal Chandra Luitel, Niroj Dahal

The Qualitative Report

Contemplation as a spiritual practice has taken various forms across different religious traditions and regions worldwide. Over the years, various contemplative practices have evolved and become popular even outside religious traditions to promote the well-being of all for inner and outer selves’ transformation. In education, many scholars worldwide have expounded on the benefits of contemplative practices in the classroom for students and teachers. Contemplative practices have penetrated research practices in the form of contemplative inquiry considering performative, philosophical, and artistic transformations, where researchers enter into a deep, thoughtful, and reflective introspective journey to see the connection between what is seen …

Multiparametric Mri Along With Machine Learning Predicts Prognosis And Treatment Response In Pediatric Low-Grade Glioma, Anahita Fathi Kazerooni, Adam Kraya, Komal Rathi, Meen Chul Kim, Arastoo Vossough, Nastaran Khalili, Ariana Familiar, Deep Gandhi, Neda Khalili, Varun Kesherwani, Debanjan Haldar, Hannah Anderson, Run Jin, Aria Mahtabfar, Sina Bagheri, Yiran Guo, Qi Li, Xiaoyan Huang, Yuankun Zhu, Alex Sickler, Matthew R Lueder, Saksham Phul, Mateusz Koptyra, Phillip Storm, Jeffrey Ware, Yuanquan Song, Christos Davatzikos, Jessica Foster, Sabine Mueller, Michael J Fisher, Adam Resnick, Ali Nabavizadeh

Department of Neurosurgery Faculty Papers

Pediatric low-grade gliomas (pLGGs) exhibit heterogeneous prognoses and variable responses to treatment, leading to tumor progression and adverse outcomes in cases where complete resection is unachievable. Early prediction of treatment responsiveness and suitability for immunotherapy has the potential to improve clinical management and outcomes. Here, we present a radiogenomic analysis of pLGGs, integrating MRI and RNA sequencing data. We identify three immunologically distinct clusters, with one group characterized by increased immune activity and poorer prognosis, indicating potential benefit from immunotherapies. We develop a radiomic signature that predicts these immune profiles with over 80% accuracy. Furthermore, our clinicoradiomic model predicts progression-free …

Optimizing Electrode Configurations For Eeg Mild Cognitive Impairment Detection, Yi Jiang, Xin Zhang, Zhiwei Guo, Xiaobo Zhou, Jiayuan He, Ning Jiang

Faculty, Staff and Student Publications

The Optimal electrode configuration of Electroencephalograms (EEG) systems for mild cognitive impairment (MCI) detection and monitoring in non-clinical settings, i.e. number of electrodes and the positions of the electrodes, remains to be explored. In the current study, we explored the optimization of electrode configuration for MCI detection. We used a 32-channel EEG device to record the data of 21 MCI patients and 20 cognitively normal elderly (NC) undergoing working memory (WM) tasks. Based on the differential value (MCI group vs. NC group) from the Power Spectral Density (PSD) value of each electrode in θ and α frequency band during WM …

Artificial Intelligence In Health Care: Business Opportunities And Ethical Challenges, Ankita Srivastava,, Marco Marabelli, Jeffrey Moriarty

Ethics Publication

Artificial intelligence (AI), and in particular generative AI (GAI), are making incredible progress toward automation. The pervasive and invasive nature of these technologies are affecting every industry, and health care is no exception. This paper summarizes insights derived from a panel that the Hoffman Center for Business Ethics and the Center for Health and Business at Bentley University hosted in March 2024. The panel invited three qualified health care professionals: Evan Carey, Susan Persky and John Torous. The panelists are all active in multiple aspects of AI in health care but represent a focus on the key areas of policy …

Chalkboards To Chatbots: Helping Faculty Harness Ai For The Future Of Higher Education, Justin C. Grace

Regis University Student Publications (comprehensive collection)

Integrating artificial intelligence (AI) into nursing education presented significant opportunities yet posed challenges due to varied faculty readiness. This Doctor of Nursing Practice (DNP) quality improvement (QI) project evaluated an educational intervention aimed at enhancing nursing faculty's AI proficiency and confidence at Regis University’s Rueckert-Hartman College for Health Professions. Using a mixed-methods, pre- and post-intervention design, validated surveys assessed changes in faculty perceptions, knowledge, and skills related to AI. The intervention included a digital toolkit with nine instructional videos demonstrating practical AI applications using FreedAI’s large language model, ChatGPT, supported by voiceover narration and closed captioning. Data analysis involved descriptive …

The Impacts Of Artificial Intelligence In Radiology, Misty Farmer, Wendy Trzyna

Theses, Dissertations and Capstones

Introduction: There has been significant growth in the use of Artificial Intelligence (AI) in the healthcare industry, especially in Medical Imaging. Radiology has been the clear frontrunner in the adoption of AI in medicine, due in part to the massive amount of digital data available for use in Deep Learning (DL) AI integration has the potential to solve multiple challenges in radiology, address workload issues and transform the field.

Purpose of the Study: The purpose of the research was to evaluate the impact of implementing Artificial Intelligence in radiology to determine if these technologies have had an impact …

A Survey-Based Quantitative Analysis Of Stress Factors And Their Impacts Among Cybersecurity Professionals, Sunil Arora, John D. Hastings

Research & Publications

This study investigates the prevalence and underlying causes of work-related stress and burnout among cybersecurity professionals using a quantitative survey approach guided by the Job Demands-Resources model. Analysis of responses from 50 cybersecurity practitioners reveals an alarming reality: 44% report experiencing severe work-related stress and burnout, while an additional 28% are uncertain about their condition. The demanding nature of cybersecurity roles, unrealistic expectations, and unsupportive organizational cultures emerge as primary factors fueling this crisis. Notably, 66% of respondents perceive cybersecurity jobs as more stressful than other IT positions, with 84% facing additional challenges due to the pandemic and recent high-profile …

Artificial Intelligence In Health Care: Business Opportunities And Ethical Challenges, Ankita Srivastava, Marco Marabelli, Jeffrey Moriarty

Philosophy Faculty Publications

Artificial intelligence (AI), and in particular generative AI (GAI), are making incredible progress toward automation. The pervasive and invasive nature of these technologies are affecting every industry, and health care is no exception. This paper summarizes insights derived from a panel that the Hoffman Center for Business Ethics and the Center for Health and Business at Bentley University hosted in March 2024. The panel invited three qualified health care professionals: Evan Carey, Susan Persky and John Torous. The panelists are all active in multiple aspects of AI in health care but represent a focus on the key areas of policy …

Artificial Intelligence In Health Care: Business Opportunities And Ethical Challenges, Ankita Srivastava, Marco Marabelli, Jeffrey Moriarty

Computer Information Systems Faculty Publications

Artificial intelligence (AI), and in particular generative AI (GAI), are making incredible progress toward automation. The pervasive and invasive nature of these technologies are affecting every industry, and health care is no exception. This paper summarizes insights derived from a panel that the Hoffman Center for Business Ethics and the Center for Health and Business at Bentley University hosted in March 2024. The panel invited three qualified health care professionals: Evan Carey, Susan Persky and John Torous. The panelists are all active in multiple aspects of AI in health care but represent a focus on the key areas of policy …

Quantifying Multidimensional Effects Of Physicochemical Parameters On Pfas Adsorption Using A Hybrid Response Surface Methodology-Machine Learning Approach, Harsh V. Patel, Jazmin Green, John Park, Stephanie Luster-Teasley Pass, Renzun Zhao

Engineering Management & Systems Engineering Faculty Publications

Per- and polyfluoroalkyl substances (PFAS) contamination has posed a significant environmental and public health challenge due to their ubiquitous nature. Adsorption has emerged as a promising remediation technique, yet optimizing adsorption efficiency remains complex due to the diverse physicochemical properties of PFAS and the wide range of adsorbent materials. Traditional modeling approaches, such as response surface methodology (RSM), struggled to capture nonlinear interactions, while standalone machine learning (ML) models required extensive datasets. This study addressed these limitations by developing hybrid RSM-ML models to improve the prediction and optimization of PFAS adsorption. A comprehensive dataset was constructed using experimental adsorption data, …

The Future Of Ai Regulation In Drug Development: A Comparative Analysis, Gabriela Lenarczyk, Timo Minssen, Nicholson Price, Arti Rai

Faculty Scholarship

As artificial intelligence (AI) transforms drug development, regulatory frameworks are evolving to oversee its implementation, particularly at the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA). This paper makes three contributions to understanding emerging regulatory approaches. First, we offer a comparative analysis of how these agencies have responded to AI-driven advances, incorporating new US executive orders and the European Union (EU)’s AI Act. Second, we propose a novel analytical framework to understand regulatory divergence: the FDA’s flexible, dialog-driven model contrasts with the EMA’s structured, risk-tiered approach, reflecting broader institutional and political-economic differences. While the former encourages …

Analysis Of Errors In The Management Of Cutaneous Disorders, Robert J. Pariser, Sarah Alnaif

Department Dermatology Faculty Publications

In this study, we prospectively and retrospectively evaluated the occurrence of errors in the management of cutaneous disorders from patient visits and medical records in a single dermatology practice in southeast Virginia over a 3-year period (June 2020-July 2023). Providers should be able to improve diagnostic accuracy by utilizing established rapid bedside diagnostic techniques.

Estimating Per-Infection Cost And Burden For Dengue And Zika As A Function Of Antibody-Dependent Enhancement, Christopher M. Kribs

Mathematics Faculty Publications - Archive

The complex immune interactions produced by the tetravalent dengue vaccine Dengvaxia have foregrounded the important role of antibody-dependent enhancement (ADE) in dengue infection. Some evidence exists that ADE may extend beyond the four dengue serotypes to Zika, a closely related flavivirus transmitted by the same mosquito species as dengue, and may also account for the increased severity of some cases. Estimates of the public health impact of dengue vaccination may then need to include its effects on the transmission of Zika in addition to dengue. This study gathers primary references to build estimates of per-case economic cost and disease burden …

Utilizing Β-Gal To Visualize Selective Transport Of The Ssa4 Gene In S.Cerevisiae, Ian M. Staertow, Rebecca L. Adams Phd

Science University Research Symposium (SURS)

In eukaryotic cells such as Saccharomyces cerevisiae, protein synthesis begins with the transport of mRNA from the nucleus to the cytoplasm. In order for mRNA to leave the nucleus, it must first bind to specific transport proteins which can then facilitate transport via the nuclear pore complex (NPC), a selectively permeable membrane within the cell's nuclear envelope. Under environmental stress, such as heat shock, S. cerevisiae cells modulate transport rates. In this case, in heat stress or “heat shock” most mRNA transcripts will remain in the nucleus. The SSA4 transcript encodes for a chaperone protein which facilitates the subsequent export …

Artificial Intelligence In Radiology, Olivia Sweeney

Theses, Dissertations and Capstones

Introduction: Artificial intelligence (AI) has increasingly transformed radiologic practice by improving diagnostic accuracy, streamlining workflows, and reducing interpretation errors. As AI integration has expanded across imaging modalities, questions have emerged regarding its effectiveness compared to traditional radiologist-only interpretation.

Purpose of Study: The purpose of this study has been to evaluate the impact of AI-assisted radiology on diagnostic accuracy, efficiency, and error reduction, while also assessing clinician perceptions of AI as a collaborative tool in imaging analysis.

Methodology: This qualitative study has used a systematic review of peer-reviewed literature published between 2015 and 2025, following PRISMA guidelines, combined with an interview …

Swosu Research And Scholarly Activity Fair 2025, Swosu Office Of Sponsored Programs

SWOSU Research and Scholarly Activity Fair Programs

On behalf of the members of the University Research and Scholarly Activity Committee (USRAC) and the Office of Sponsored Programs (OSP) at Southwestern Oklahoma State University (SWOSU) — welcome to the Thirty-Third SWOSU Research and Scholarly Activity Fair!

This year’s event features 99 poster presentations and 9 oral presentations, showcasing the work of over 170 student and faculty researchers, writers, presenters, artists, collaborators, and faculty sponsors. These presentations represent a wide array of scholarly and academic activity from across SWOSU’s academic community, including the Departments of Art, Communication, and Theatre; Allied Health Sciences; Biological Sciences; Business; Chemistry & …

Online Learning-Driven Human Intent Estimation And Control For Human-Robot Interaction, Irfan Ganie, S. Jagannathan

Electrical and Computer Engineering Faculty Research & Creative Works

This paper presents a novel Stackelberg-game theoretic multilayer-online learning framework for cooperative control of nonlinear Physical Human-Robot Interaction (pHRI), where the human is modeled as the leader guiding a robot follower. This hierarchical interaction is captured as a dynamic Stackelberg game, with the human's intention estimated in real-time through online multilayer neural networks (MNNs). We introduce SVD-based weight update laws for actor-critic MNNs, which approximate value functions and control inputs for both human and robot, eliminating the need for predefined basis functions. In this framework, the human objective is first inferred and used to guide the robot actions by shaping …

Improved Optimal Tracking Of Uncertain Nonlinear Discrete-Time Systems Using Experience Replay, Maxwell Geiger, Sarangapani Jagannathan

Electrical and Computer Engineering Faculty Research & Creative Works

This paper addresses the infinite horizon optimal tracking control problem for partially uncertain control-affine nonlinear discrete-time (DT) systems, where the control input dynamics are known. Multi-layer critic and actor neural networks (MNNs) are utilized for online estimation of the infinite horizon value function and optimal control input. The NN weights are tuned online using a direct temporal difference error (TDE)-driven learning approach, which modifies the singular values of the gradient with respect to the NN weights to accelerate their convergence. The critic NN uses a novel experience replay technique to improve sample efficiency without introducing biased TDEs and guarantee the …

Multi-Model Safe Neuro-Optimal Output Tracking Control Of Autonomous Surface Vessels With Explainable Ai, Behzad Farzanegan, S. Jagannathan

Electrical and Computer Engineering Faculty Research & Creative Works

This paper presents a safety-aware deep reinforcement learning (DRL)-based trajectory tracking control of autonomous surface vessels (ASVs). A multilayer neural network (MNN) observer estimates the ASV's state and uncertain dynamics. By utilizing the estimate state vector from the observer, a safety-aware DRL-based optimal policy is formulated using control barrier function (CBF) and Karush-Kuhn-Tucker (KKT) conditions. An actor-critic MNN with singular value decomposition (SVD)-based update mitigates vanishing gradients. To enhance adaptability, an online safe lifelong learning (SLL) scheme counters catastrophic forgetting across varying ASV dynamics. The Shapley Additive Explanations (SHAP) method identifies key features influencing the control policy. Simulations on an …

Online Adaptive Optimal Tracking Control Of Uncertain Strict Feedback Discrete-Time Systems With Hardware Verification Using A Quadrotor Uav, Maxwell Geiger, S. Jagannathan

Electrical and Computer Engineering Faculty Research & Creative Works

This article considers the infinite time horizon optimal tracking control problem for discrete time (DT) partially uncertain strict feedback systems with application to quadrotor UAVs. First, the strict feedback DT system is transformed into an equivalent affine nonlinear DT system in terms of tracking error dynamics. The optimal tracking control problem is solved using an augmented system approach, where a horizon of future reference trajectory points are used in the augmented state, as compared to using a single point. The internal dynamics of the original nonlinear strict feedback system and the transformed affine system in terms of error dynamics are …

Reinforcement Learning-Based Nonlinear Optimal Discrete-Time Control Of Power Systems, Vijay Kumar Singh, Behzad Farzanegan, S. Jagannathan

Electrical and Computer Engineering Faculty Research & Creative Works

This paper presents a partially model-free adaptive optimal tracking control method for power systems, specifically targeting a synchronous generator connected through a reactive transmission line. By integrating the tracking error dynamics with reference trajectory dynamics, an augmented system is created. A discounted performance function is introduced to address the nonlinear tracking problem optimally. Unlike traditional methods that compute feedforward and feedback terms separately, the proposed approach calculates both simultaneously by minimizing the discounted performance function. The discrete-time tracking Bellman and Hamilton-Jacobi-Bellman (HJB) equations are derived, and a reinforcement learning (RL)-based technique is employed to solve the optimal policy online without …

Artificial Intelligence In Cancer-Related Malnutrition And Cachexia: A Transformative Tool In Clinical Nutrition, Salvatore Carbone

EVMS School of Health Professions Faculty Publications

[Introduction] Malnutrition and cachexia are common complications in cancer patients, and they negatively influence prognosis, treatment efficacy, and tolerability as well as quality of life [[1], [2], [3]]. Accurately identifying and effectively managing malnutrition and cachexia in this population remains a clinical challenge. Conventional validated screening tools may lack the sensitivity and specificity required for early detection and personalized intervention in diverse cancer types and treatment settings [4,5]. Over the last decade, the use of artificial intelligence (AI), including machine learning (ML) and deep learning (DL) strategies, has shown promising results in clinical nutrition, with the potential to revolutionize nutritional …

Enhanced Continual Reinforcement Learning-Based Output Feedback Control Of Heterogeneous Quadrotors Formation, Ehsan Soleimani, S. Jagannathan

Electrical and Computer Engineering Faculty Research & Creative Works

This paper presents a unified framework for the safe and optimal control of heterogeneous quadrotor unmanned aerial vehicles (QUAVs) in formation, enabling multitask missions without requiring precise system dynamics. To address partial state observability, a multilayer neural network (MNN) observer is designed to estimate unmeasured states. Reinforcement learning (RL) is employed for optimal control utilizing an MNN ensuring adaptability. Barrier Lyapunov Functions (BLFs) are integrated into the RL framework to enforce safety by maintaining QUAVs within predefined constraints. An enhanced continual learning (ECL) method is proposed to improve the adaptability of MNNs. This method enables effective multitask learning while mitigating …

Optimizing Decision-Making In A Cerebral Palsy Model Using Reinforcement Learning, Richard Ampah

Pitzer Senior Theses

This study presents an original interdisciplinary investigation into how reinforcement learning (RL) can model motor and cognitive defects and potentially improve motor and cognitive functions in individuals with cerebral palsy (CP), a non-progressive neurological disorder that impairs movement and adaptability. Integrating computational neuroscience and machine learning, the research applies policy gradient methods and Markov Decision Processes (MDPs) to simulate adaptive learning in agents with and without CP-related constraints.

The central aim is to compare the cumulative rewards of optimal policies, derived from value iteration, and human-like learning policies using the REINFORCE algorithm, both with and without the Bellman baseline. The …

The Anatomy Of A Reconstruction: From Fourier Space To Image Recovery In Computed Tomography, Charlotte P. Maurer

Honors Theses

This thesis develops the mathematical foundations of computed tomography (CT) reconstruction through the lens of harmonic analysis. Beginning with the Schwartz class, we introduce the Fourier transform and its role in expressing the Radon transform and its inversion via a fractional Laplacian. After constructing the Radon transform in general dimension R^d, we specialize to the cases d = 2 and d = 3, demonstrating explicit inversion formulas and the associated instability in lower dimensions. For its computational advantages, we study filtered back-projection using classical low-pass filters (Ram-Lak, Shepp–Logan, Cosine, Gaussian) and formulate a discrete reconstruction algorithm grounded in …