Medicine and Health Sciences Commons^™

C22: Eravacycline Versus Best Previously Available Therapy In Adults With Pneumonia Due To Drug-Resistant Acinetobacter Baumannii, Courtney Jane Scott, Rebecca Jayakumar, Elizabeth Zhu, Velliyur Viswesh

Annual Research Symposium

There are no published studies documenting outcomes with the use of eravacycline against drug-resistant Acinetobacter baumannii. The purpose of this study is to assess the efficacy of eravacycline use, in comparison to best previously available therapy, in patients with drug-resistant Acinetobacter baumannii pneumonia.

C20: A Comparison Of Heparin Vs Bivalirudin In Patients Undergoing Percutaneous Coronary Intervention (Pci) In Achieving Therapeutic Activated Clotting Time, Priyanga Radjassegarane, Ragini Bhakta, Joanne Dominguez

Annual Research Symposium

No abstract provided.

C17: Programmed Cell Death Ligand- 1 Expression As A Prognostic Indicator In Oral Squamous Cell Carcinoma, Dr. Samar Saeed Khan

Annual Research Symposium

No abstract provided.

C16: On-The-Spot Transport Media For The Freshly Biopsied Soft Tissue Specimen: A Comparative Study, Snehashish Ghosh

Annual Research Symposium

No abstract provided.

C10: Oral Potentially Malignant Disorders Prevalence In The Orthodontic Clinic, Mark Greene

Annual Research Symposium

No abstract provided.

C8: Intravenous (Iv) Bolus Versus Iv Infusion As Initial Approach For Blood Pressure (Bp) In Acute Ischemic Stroke (Ais) Patients Receiving Tissue-Plasminogen Activator (Tpa), Alexander D. Bonca, Alana Whittaker

Annual Research Symposium

No abstract provided.

C4: Comparing The Sub-Gingival Levels Of Cytomegalovirus, Epstein-Barr Virus, Porphyromonas Gingivalis In Human Immunodeficiency Virus-1 Seropositive Patients With And Without Antiretroviral Therapy, Supriya Kheur

Annual Research Symposium

No abstract provided.

S3: Post-Covid-19 Recovery Care Plan For Older Adults With Continuing Symptoms Of Breathlessness And Fatigue, Nancy M. Bryan, Marie Wright-Rolf Edd, Msn, Rn, Siboney Zelaya Ph.D., Mph, Msn Ed, Rn, Justin Carbonel

Annual Research Symposium

Background:

The CDC research actively continues gathering information related to short and long-term symptoms that remain following the acute phase of Covid-19 diagnosis (CDC, 2020).

Fatigue and shortness of breath are listed among the most commonly reported long-term symptoms of Covid-19:

1. Fatigue
2. Shortness of Breath
3. Cough
4. Joint Pain
5. Chest Pain (CDC, 2020).

Evidence suggests that older adults over the age of 60 who have multiple comorbidities are more susceptible and are at a higher risk of contracting the Covid-19 virus thus potentially prolonging recovery time post diagnosis (Greenhalgh, Knight, A’Court, Buxton, & Husain, 2020).

The Agency for Healthcare Research and …

P14: Emerging Role Of Pharmacists In Treatment And Vaccination For Covid-19, Dwaynie Bacon Jr, Man Ha, Dr. Mandal

Annual Research Symposium

No abstract provided.

P5: Covid-19 Vaccine: Technology Platform, Efficacy And Immune Protection, Manas Mandal

Annual Research Symposium

Roseman Research Day Symposium.

P2: Characteristics Of Individuals With Oral Hpv Positive Results, Val Cheever, Eric Hon, Andrew J. Gross, Man Hung

Annual Research Symposium

No abstract provided.

O2: In-Silico Approach To Analyze Anticancer Activity Of Withania Somnifera In Oral Cancer, Gauri Kumbhar

Annual Research Symposium

No abstract provided.

Socastee Interview, Participant #07, April 12, 2021, Jennifer Mokos, Jaime Mccauley

Flood Survivor Interviews

A community member of the Rosewood neighborhood in Socastee is interviewed by CCU students.

Chromosome Xq23 Is Associated With Lower Atherogenic Lipid Concentrations And Favorable Cardiometabolic Indices, Pradeep Natarajan, Akhil Pampana, Sarah E. Graham, Sanni E. Ruotsalainen, James A. Perry, Paul S. De Vries, Jai G. Broome, James P. Pirruccello, Michael C. Honigberg, Krishna Aragam, Brooke Wolford, Jennifer A. Brody, Lucinda Antonacci-Fulton, Moscati Arden, Stella Aslibekyan, Themistocles L. Assimes, Christie M. Ballantyne, Lawrence F. Bielak, Joshua C. Bis, Brian E. Cade, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

Autosomal genetic analyses of blood lipids have yielded key insights for coronary heart disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in large sample sizes. We now analyze genetic and blood lipid data in a high-coverage whole X chromosome sequencing study of 65,322 multi-ancestry participants and perform replication among 456,893 European participants. Common alleles on chromosome Xq23 are strongly associated with reduced total cholesterol, LDL cholesterol, and triglycerides (min P = 8.5 × 10⁻⁷²), with similar effects for males and females. Chromosome Xq23 lipid-lowering alleles are associated with reduced odds for CHD among 42,545 …

Development Of A Rapid Drug Detection Method For Insects Using Paper Spray Ionization Mass Spectrometry (Psi-Ms), Alexandria Plyler

Undergraduate Research and Scholarship Symposium

Insects have the ability to reflect the chemical environment that they have developed in. Thus, necrogenous insects can reflect the chemical environment of cadavers they have fed on. Forensic scientists can potentially utilize insect larvae as an alternate biological matrix to detect drugs in cadavers that are skeletonized, burned, or otherwise badly damaged. Analysis of insects using paper spray ionization mass spectrometry (PSI-MS), an analytical method requiring little to no sample preparation, could prove a rapid, cost-effective, and non-destructive alternative form of toxicological analysis. Traditional tissue analysis via GC and LC-MS often require lengthy sample preparation, use expensive reagents, and …

Dietary Inflammatory Index Is Associated With Inflammation In Japanese Men, Ayaka Kotemori, Norie Sawada, Motoki Iwasaki, Taiki Yamaji, Nitin Shivappa Mbbs, Mph, Ph.D., James Hébert Scd, Junko Ishihara, Manami Inoue, Shoichiro Tsugane

Faculty Publications

Background: Dietary components are known to affect chronic low-grade inflammation status. The dietary inflammatory index (DII®) was developed to measure the potential impact of a diet on an individual's inflammatory status, and it has been validated mainly in Western countries.

Objective: This study aimed to examine the validity of the energy-adjusted DII (E-DIITM) using high-sensitivity C-reactive protein (hs-CRP) concentration in Japanese men and women.

Methods: In total, 6,474 volunteers from a cancer-screening program (3,825 men and 2,649 women) completed a food frequency questionnaire (FFQ) and their hs-CRP concentrations were evaluated. E-DII scores were calculated on the basis of 30 food …

Socastee Interview, Participant #11, April 8, 2021, Jennifer Mokos, Jaime Mccauley

Flood Survivor Interviews

A community member of the Rosewood neighborhood in Socastee is interviewed by a CCU student.

Change In Dietary Inflammatory Index Score Is Associated With Control Of Long-Term Rheumatoid Arthritis Disease Activity In A Japanese Cohort: The Tomorrow Study, Yoshinari Matsumoto, Nitin Shivappa Mbbs, Mph, Ph.D., Yuko Sugioka, Masahiro Tada, Tadashi Okano, Kenji Mamoto, Kentaro Inui, Daiki Habu, James R. Hébert Scd, Tatsuya Koike

Faculty Publications

Background: The dietary inflammatory index (DII®), a quantitative measure of the inflammatory potential of daily food and nutrient intake, and associations between a variety of health outcomes have been reported. However, the association between DII score and disease activity of rheumatoid arthritis (RA) is unclear. Therefore, this study was designed to test whether higher DII score contributes to disease activity and as a corollary, y, whether reducing DII score helps to achieve or maintain low disease activity or remission in patients with RA.

Methods: We performed a cross-sectional and longitudinal analysis using 6 years of data (from 2011 to 2017) …

Covid-19 And Preparing Planetary Health For Future Ecological Crises: Hopes From Glycomics For Vaccine Innovation, Xueqing Wang, Zhaohua Zhong, Wei Wang

Research outputs 2014 to 2021

A key lesson emerging from COVID-19 is that pandemic proofing planetary health against future ecological crises calls for systems science and preventive medicine innovations. With greater proximity of the human and animal natural habitats in the 21st century, it is also noteworthy that zoonotic infections such as COVID-19 that jump from animals to humans are increasingly plausible in the coming decades. In this context, glycomics technologies and the third alphabet of life, the sugar code, offer veritable prospects to move omics systems science from discovery to diverse applications of relevance to global public health and preventive medicine. In this expert …

Using Enclosed Y-Mazes To Assess Chemosensory Behavior In Reptiles, M. Rockwell Parker, Andrea F. Currylow, Eric A. Tillman, Charlotte J. Robinson, Jilian M. Josimovich, Isabella M.G. Bukovich, Lauren A. Nazarian, Melia G. Nafus, Bryan M. Kluever, Amy A. Yackel Adams

United States Department of Agriculture Wildlife Services: Staff Publications

Reptiles utilize a variety of environmental cues to inform and drive animal behavior such as chemical scent trails produced by food or conspecifics. Decrypting the scent-trailing behavior of vertebrates, particularly invasive species, enables the discovery of cues that induce exploratory behavior and can aid in the development of valuable basic and applied biological tools. However, pinpointing behaviors dominantly driven by chemical cues versus other competing environmental cues can be challenging. Y-mazes are common tools used in animal behavior research that allow quantification of vertebrate chemosensory behavior across a range of taxa. By reducing external stimuli, Y-mazes remove confounding factors and …

Dietary Inflammatory Index Is Related To Heart Failure Risk And Cardiac Function: A Case-Control Study In Heart Failure Patients, Jalal Moludi, Nitin Shivappa Mbbs, Mph, Ph.D., Soghra Alisgharzadeh, James R. Hébert Scd, Mohammad Alizadeh

Faculty Publications

Aims: Previous studies suggest that diet and inflammation are important risk factors for heart failure (HF); however, the associations remain unclear. The Dietary Inflammatory Index (DII®) was established to measure the inflammatory capacity of individuals' diet. This study aimed to explore the DII in HF subjects compared with controls. Methods and Results: We conducted a case–control (116 cases and 113 controls) study that recruited in the similar clinics. DII scores were calculated based on dietary intakes. N-Terminal pro-brain natriuretic peptide (NT-proBNP) levels and ejection fraction (EF) were assessed in both groups. In order to analyze DII scores with HF as …

Predicting Tumor Response To Radiotherapy Based On Estimation Of Non-Treatment Parameters, Yutian Huang, Allison L. Lewis

Spora: A Journal of Biomathematics

Though clinicians can now collect detailed information about a variety of tumor characteristics as a tumor evolves, it remains difficult to predict the efficacy of a given treatment prior to administration. Additionally, the process of data collection may be invasive and expensive. Thus, the creation of a framework for predicting patient response to treatment using only information collected prior to the start of treatment could be invaluable. In this study, we employ ordinary differential equation models for tumor growth and utilize synthetic data from a cellular automaton model for calibration. We investigate which parameters have the most influence upon treatment …

Timing Of Term Elective Cesarean Section And Adverse Neonatal Outcomes: A Multi-Center Retrospective Cohort Study, Ayah Al Bizri, Nansi Boghossian, Anwar Nassar, Pascale Nakad, Dina Jaber, Rabih Chahine, Gaby Fallakha, Gjaotj Makhoul, Khalid Yunis

Faculty Publications

Background Rate of cesarean section (CS), including elective CS has globally increased. Studies have found that term elective CS before 39 weeks of gestation is associated with increased risk of adverse respiratory outcomes.

Objective To determine the rate of elective CS and examine the association between timing of elective term CS and adverse neonatal outcomes in a large population of Lebanese women.

Methods A Multi-Center Study was conducted using data from the National Collaborative Perinatal Neonatal Network database. Simple and multivariable logistic regression models were used to examine the association between timing of term elective CS and adverse neonatal outcomes. …

Age And Sex Are Associated With The Plasma Lipidome: Findings From The Goldn Study, Emily Slade, Marguerite R. Irvin, Kevin Xie, Donna K. Arnett, Steven A. Claas, Tobias Kind, David W. Fardo, Gregory A. Graf

Biostatistics Faculty Publications

Background
Developing an understanding of the biochemistry of aging in both sexes is critical for managing disease throughout the lifespan. Lipidomic associations with age and sex have been reported, but prior studies are limited by measurements in serum rather than plasma or by participants taking lipid-lowering medications.

Methods
Our study included lipidomic data from 980 participants aged 18–87 years old from the Genetics of Lipid-Lowering Drugs and Diet Network (GOLDN). Participants were off lipid-lowering medications for at least 4 weeks, and signal intensities of 413 known lipid species were measured in plasma. We examined linear age and sex associations with …

The Present And Future Of Artificial Intelligence In Ophthalmology, Robert Abishek, Elliot Cherkas

inSIGHT

Dr. Ravi Goel is a comprehensive ophthalmologist and cataract surgeon at Wills Eye Hospital, with a specific interest in finding ways that AI can help ophthalmologists improve their clinical care and treat more patients. Dr. Goel also publishes a daily blog, Protecting Sight, where he discusses a variety of topics ranging from advances in cataract surgery to medical education. One common thread throughout his blog is the burgeoning impact of AI on the field of ophthalmology, such as the utility of deep learning algorithms for diagnosing various diseases and the impact that improved intra-ocular lens (IOL) power calculations will have …

Socastee Interview, Participant #02, April 2, 2021, Jennifer Mokos, Jaime Mccauley

Flood Survivor Interviews

A community member of the Rosewood neighborhood in Socastee is interviewed by a CCU student.

Through The Eye Of The Beholder: Student Teaching In Kentucky During A Pandemic, Brittany Stidham, Kimberely Nettleton, Sandra Riegle

2021 Celebration of Student Scholarship - Poster Presentations

Student teaching is the capstone of student teaching preparation. The Covid-19 pandemic has changed many aspects of student teaching; and students have had to adapt to a new way of both learning and teaching. As the world turned upside down, student teachers were expected to interact with their students and provide instruction. The pandemic caused student teachers to develop new ways to engage lessons and hold conversations in a virtual environment. This pilot study examines the ways in which a small group of student teachers in eastern Kentucky internalized their experience.

Evidence Based Evaluation Of A Ventilator Management Clinical Practice Protocol, Kyle Mills, Michelle Mcclave

2021 Celebration of Student Scholarship - Poster Presentations

Nursing care and management of mechanically ventilated patients requires specific care elements to be achieved in order for optimal patient outcomes. The ventilator management policy guides nursing care for this select group of patients. The ventilator management policy of a rural community acute healthcare facility was evaluated for evidence-base and validity using the AGREE GRS rating scale. The evaluation process included interview of the director of the inpatient unit responsible for care of ventilator patients, as well as review of the most current evidence-based practice protocols. Evaluation results indicate the facility’s policy met the needs of the patients, and incorporated …

A Portable Analyzer For Rapid And Sensitive Protein Detection By Ac Electrokinetics Capacitive Sensing, Allie Skaggs, Cheng Cheng

2021 Celebration of Student Scholarship - Poster Presentations

Capacitive bioparticle detection is a promising method for point-of-care diagnosis. There are a wide range of applications for such a device: diagnostics, pharmacology, and medical science. The end goal of this project is to develop a portable capacitive sensing platform for rapid and sensitive bioparticles detection. When bioparticles bind to receptors located on the surface of the electrode there would be a change in the interfacial capacitance, which indicate the presence of the bioparticle. The ADuCM355 – a precision analog microcontroller with a chemical sensor interface – is being used to perform biased electrochemical impedance spectroscopy (EIS). An AC potential …

Catalogue Of Lichen Species In The Rowan County Sphagnum Swamp, Rowan County, Kentucky, Deanna Kidd, Allen Risk

2021 Celebration of Student Scholarship - Poster Presentations

Rowan County Sphagnum Swamp is one of the best remaining examples of a bottomland swamp forest left in the Knobs region of Kentucky. Bottomland swamp forests are characterized by soil with a high percentage of organic matter above clay and Devonian shale. This arrangement leads to standing water much of the year and a strongly acidic soil. Common tree species in the Rowan County Sphagnum Swamp include Acer rubrum (red maple), Quercus palustris (pin oak), Liquidambar styraciflua (sweet gum), Nyssa sylvatica (sour gum) and Betula nigra (river birch). Bottomland swamp forests used to be more common, but have dwindled due …