Medicine and Health Sciences Commons^™

Understanding The Effect Of Adaptive Mutations On The Three-Dimensional Structure Of Rna, Justin Cook

Undergraduate Research and Scholarship Symposium

Single-nucleotide polymorphisms (SNPs) are variations in the genome where one base pair can differ between individuals.¹ SNPs occur throughout the genome and can correlate to a disease-state if they occur in a functional region of DNA.¹According to the central dogma of molecular biology, any variation in the DNA sequence will have a direct effect on the RNA sequence and will potentially alter the identity or conformation of a protein product. A single RNA molecule, due to intramolecular base pairing, can acquire a plethora of 3-D conformations that are described by its structural ensemble. One SNP, rs12477830, which …

Disparities In Meeting Uspstf Breast, Cervical, And Colorectal Cancer Screening Guidelines Among Women In The United States, Gabriel A. Benavidez, Anja Zgodic, Whitney Zahnd, Jan Eberth

Faculty Publications

Introduction

Many sociodemographic factors affect women’s ability to meet cancer screening guidelines. Our objective was to examine which sociodemographic characteristics were associated with women meeting US Preventive Services Task Force (USPSTF) guidelines for breast, cervical, and colorectal cancer screening.

Methods

We used 2018 Behavioral Risk Factor Surveillance System data to examine the association between sociodemographic variables, such as race/ethnicity, rurality, education, and insurance status, and self-reported cancer screening for breast, cervical, and colorectal cancer. We used multivariable log-binomial regression models to estimate adjusted prevalence ratios and 95% CIs.

Results

Overall, the proportion of women meeting USPSTF guidelines for breast, cervical, …

Socastee Interview, Participant #13, April 14, 2021, Jennifer Mokos, Jaime Mccauley

Flood Survivor Interviews

A community member of the Rosewood neighborhood in Socastee is interviewed by a CCU student.

Conjunction Of Factors Impacting The 2019-2020 Flu Season In The Us, Yichen Wang

Undergraduate Research Symposium 2021

The 2019-2020 flu season is regarded as one of the most serious ones in decades. Previous researchers usually studied the effects of different factors on seasonal flu separately instead of their conjugate impact, so we wanted to find how multiple factors combine to affect the spread of influenza in the 2019-2020 flu season in America. We chose types of virus (A and B), environmental factors (temperature, precipitation, relative humidity), population density, and influenza vaccination status for different age groups which are statewide data containing monthly information from Sep. 2019 to May 2020. By principal component analysis, we could see the …

Study Of Potential Drug For Alzheimer’S Disease: Small Organic Molecules, 1,5-Dhn And Tmpyp Inhibit Amyloid-Β Peptide Aggregation And Quench Hydroxyl Radicals, Matthew Murphy

Undergraduate Research Conference

Alzheimer disease (AD) is recognized as the six leading cause of the death in the United States. As of now, there is no cure for this fatal disease. The current treatment methods can only temporarily slow the worsening of symptoms. Research data suggested that an excess generation of hydroxyl radical in the brain causing the aggregation of Amyloid-β (Aβ) peptide which is considered to be responsible for Alzheimer's disease. Thus, there is a pressing need to find a suitable drug which can quench hydroxyl radicals effectively and stop or slow down the formation of aggregation of Aβ peptide. The primary …

A Novel Molecular And Cellular Study On Curcumin, Khang Nguyen

Undergraduate Research Conference

Since the discovery of G-quartet (G4)by M. Gellertin 1962, much attention has been given on G4and C4(also called i-motif) as important drug design targets for the treatment of various human disorders. G4 forming sequences are prevalent in human genome, which includes many important regions of the eukaryotic genome, such as telomere ends, regulatory regions of many oncogenes c-kit, proto-oncogene c-myc, Kirsten rat sarcoma viral oncogene homolog (KRas). Curcumin(diferuloylmethane), an antiinflammatory and antioxidant compound, is found in the rhizomes of the plant Curcuma longa. The phytopolyphenolic chemical curcumin has been in the prominence due to its diverse pharmacological activities. Here, we …

Biotransformation Of Hbe And Other Benzofuran Derivatives, Hannah Trauger

Undergraduate Research Conference

No abstract provided.

Implications Of The Quantum Dna Model For Information Sciences, F. Matthew Mihelic

Faculty Publications

The DNA molecule can be modeled as a quantum logic processor, and this model has been supported by pilot research that experimentally demonstrated non-local communication between cells in separated cell cultures. This modeling and pilot research have important implications for information sciences, providing a potential architecture for quantum computing that operates at room temperature and is scalable to millions of qubits, and including the potential for an entanglement communication system based upon the quantum DNA architecture. Such a system could be used to provide non-local quantum key distribution that could not be blocked by any shielding or water depth, would …

Magnetic Vector Potential Manipulation Of Majorana Fermions In Dna Quantum Logic, F. Matthew Mihelic

Faculty Publications

In the quantum logic of the DNA molecule, electrons are held and conducted coherently as spinless Cooper pairs and are shielded from electromagnetic energy by a Faraday cage effect of the double lipid bilayer of the nuclear membrane. The magnetic vector potential generated by cellular depolarization can synchronize logical activity in portions of the DNA molecule by affecting spin directions of appropriately oriented spinless electrons via the Aharonov-Bohm effect, but is not blocked by that Faraday cage effect. Within the logically and thermodynamically reversible chiral enantiomeric symmetry of the deoxyribose moieties the decoherent transition of Cooper pair to Dirac pair …

Human Ace2‑Functionalized Gold “Virus‑Trap” Nanostructures For Accurate Capture Of Sars‑Cov‑2 And Single‑Virus Sers Detection, Yong Yang, Yusi Peng, Chenglong Lin, Li Long, Jingying Hu, Jun He, Hui Zeng, Zhengren Huang, Zhi-Yuan Li, Masaki Tanemura, Jianlin Shi, John R. Lombardi, Xiaoying Luo

Publications and Research

The current COVID-19 pandemic urges the extremely sensitive and prompt detection of SARS-CoV-2 virus. Here, we present a Human Angiotensin-converting-enzyme 2 (ACE2)-functionalized gold “virus traps” nanostructure as an extremely sensitive SERS biosensor, to selectively capture and rapidly detect S-protein expressed coronavirus, such as the current SARS-CoV-2 in the contaminated water, down to the single-virus level. Such a SERS sensor features extraordinary 106- fold virus enrichment originating from high-affinity of ACE2 with S protein as well as “virus-traps” composed of oblique gold nanoneedles, and 109- fold enhancement of Raman signals originating from multicomponent SERS effects. Furthermore, the identification standard of virus …

"Inclusive Inquiry." 14th Annual Research Week: Event Proceedings, University Of The Incarnate Word

Excellence Summit (Research Week) Archived Proceedings

Presentations of completed and ongoing research activity conducted by graduate and undergraduate students and faculty at University of the Incarnate Word. Coordinated and presented by the Office of Research and Graduate Studies.

B36: Comparing The Nephrotoxic Effects Of Cisplatin In Combination With Docetaxel Or 5-Fluorouracil, Ria Lei Marie Natividad

Annual Research Symposium

No abstract provided.

B35: Development And Validation Of A Stability Indicating Hplc Method For Quantification Of Estriol In Compounded Glycerinated Gelatin Troches, Tayler Hutto

Annual Research Symposium

No abstract provided.

B31: Identifying New G Protein Coupled Receptor Kinase 2 And 3 Substrates Among Proteins Closely Linked To Breast Cancer With Positive Prognosis, Theresa Tran

Annual Research Symposium

No abstract provided.

B30: Identifying New G Protein Coupled Receptor Kinase 6 Substrates Among Proteins Closely Linked To Prognoses Of Pancreatic Cancer, Christine Taing, Jelena Jovanovic, Nicole Khalil, Christopher So

Annual Research Symposium

No abstract provided.

B29: Exploring The Role Of G Protein Coupled Receptor Kinases In Modulating Behaviors To Fluoxetine Using Caenorhabditis Elegans As An Experimental Model, Victoria Pang

Annual Research Symposium

No abstract provided.

B28: Evaluating The Chemotherapeutic Effects Of The Fac Regimen In Mda Mb 231 Breast Cancer Cells With Reduced Beta Arrestin 2 Expression Levels, Angelina Marcee

Annual Research Symposium

No abstract provided.

B27: Evaluating The Chemotherapeutic Effects Of The Fac Regimen In Mda Mb 231 Breast Cancer Cells With Reduced G Protein Coupled Receptor Kinase 2 Expression, Samantha Bodan

Annual Research Symposium

No abstract provided.

B24: Efficacy Of Scaffold Mediated Localized Chemotherapy In Cancer: A Systematic Review, Archana Gupta

Annual Research Symposium

No abstract provided.

B21: Exposure To Vape Smoke Enhances Sperm Mitochondrial Respiration In Mature Mice., Jeremy Y. Saito

Annual Research Symposium

No abstract provided.

B14: Angiogenic Potential Of Oral Cavity Derived Mesenchymal Stem Cells And Its Secretomes: A Systematic Review, Madhura Rajendra Shekatkar

Annual Research Symposium

No abstract provided.

B2: Presence Of Immunosuppressive Drugs Affect Innate Immune Response And Monocyte Differentiation In Lung Transplant Patients, Inayat Kaur Oms Iii, Ryan Wang Oms Ii, Amy E.L. Stone

Annual Research Symposium

Lung transplant patients are administered Immunosuppressive Drugs (ISDs) to prevent transplant rejection, but this also puts them at constant risk of infection due to the decreased ability of the immune system to respond to subsequent infections by viruses, bacteria etc.

Purpose

This paper focuses on the effect of ISDs on the innate immune response. We are using different parts of viruses and bacteria and allowing them to represent the organism as a whole.

Methods

As representatives of the innate immune system, we are going to be testing monocyte, macrophage, and dendritic cell lineages. We are hypothesizing that the presence of …

C43: Telehealth In The Emergency Department: Impact On Wait Times, Alexander Romero, Carmela Bautista, Gabriella Kelley, Mackenzie Hazen, Rebecca Pullen, Vicente Lujan

Annual Research Symposium

Undergraduate nursing students investigated if implementing telehealth in the Emergency Department (ED) can help reduce wait times.

C41: Treating Proctitis And Pouchitis: A Systematic Review Of Clinical Trial Data, Sarah Tesfaye

Annual Research Symposium

No abstract provided.

C37: Evaluation Of The Diagnostic Efficacy Of Saliva For Detection Of Dengue Antibodies- An Elisa Study, Vidya Gurram Shankar

Annual Research Symposium

No abstract provided.

C36: Clinical Evaluation Of Bupivacaine Liposomal, Samaya Cristina (Shuput)

Annual Research Symposium

No abstract provided.

C33: Covid Encephalitis Resulting In Focal Seizures With Subsequent Changes On Mri Imaging, Adena Shahinian

Annual Research Symposium

No abstract provided.

C30: A Comparison Of Cbct Soft Tissue With Bellus3d Facial Scan Superimposition, Gerald Sherrick

Annual Research Symposium

Research Symposium

C29: Epilepsy Partialis Continua With Transient Post-Ictal Changes On Mri, Trusha Mehta Do

Annual Research Symposium

No abstract provided.

C28: Acute Encephalopathy As A Presenting Sign Of Suspected Lupus Cerebritis, Jasmine Chopra

Annual Research Symposium

No abstract provided.