Medicine and Health Sciences Commons^™

Evaluating The Effect Of Sodium Zirconium Cyclosilicate In Acute Hyperkalemia Management, Austin Brandes, Hannah Thompson, Paul Huiras

Pharmacy Posters

Introduction

• Sodium zirconium cyclosilicate (ZS-9) can acutely decrease serum potassium (K) levels after one dose and may have favorable side effects compared to sodium polystyrene sulfate (SPS).
• ZS-9 replaced oral SPS in the Hyperkalemia Order Set at St. Cloud Hospital in April 2019

Purpose

• To characterize the acute potassium-lowering effects of one 10-gram dose of sodium zirconium cyclosilicate in conjunction with other potassium-lowering medications

A Bird's-Eye View Of The Multiple Biochemical Mechanisms That Propel Pathology Of Alzheimer's Disease: Recent Advances And Mechanistic Perspectives On How To Halt The Disease Progression Targeting Multiple Pathways., Caleb Vegh, Kyle Stokes, Dennis Ma, Darcy Wear, Jerome Cohen, Sidhartha D. Ray, Siyaram Pandey

Touro College of Pharmacy (New York) Publications and Research

Neurons consume the highest amount of oxygen, depend on oxidative metabolism for energy, and survive for the lifetime of an individual. Therefore, neurons are vulnerable to death caused by oxidative-stress, accumulation of damaged and dysfunctional proteins and organelles. There is an exponential increase in the number of patients diagnosed with neurodegenerative diseases such as Alzheimer’s (AD) as the number of elderly increases exponentially. Development of AD pathology is a complex phenomenon characterized by neuronal death, accumulation of extracellular amyloid-β plaques and neurofibrillary tangles, and most importantly loss of memory and cognition. These pathologies are most likely caused by mechanisms including …

Formation Primaquine-5, 6-Orthoquinone, The Putative Active And Toxic Metabolite Of Primaquine Via Direct Oxidation In Human Erythrocytes, P. S. Fasinu, N. D. Nanayakkara, Y. H. Wang, N. D. Chaurasiya, H. B. Herath, J. D. Mcchesney, B. Avula, I. Khan, B. L. Tekwani, L. A. Walker

Pharmaceutical Sciences

No abstract provided.

Tablets: A Brief Overview, A. J. Al-Achi

Pharmaceutical Sciences

No abstract provided.

Psychoactive Botanicals And Their Constituents: A Brief Review, A. J. Al-Achi

Pharmaceutical Sciences

No abstract provided.

Cardiovascular Outcomes In Patients Over 75 Years Of Age Taking A Statin For Primary Prevention, S. R. Taylor, D. Maybin, A. J. Al-Achi

Pharmaceutical Sciences

No abstract provided.

Determining Sucrose Concentration In Syrups By Pharmaceutical Methods, A. J. Al-Achi, A. Y. Kanade

Pharmaceutical Sciences

No abstract provided.

Cannabidiol Coated 3d Printed Microneedles For Transdermal Diffusion, Gowthami Thota

Pharmaceutical Sciences

No abstract provided.

Pediatric Milk Based Efavirenz Freeze-Dried Nanoemulsion; Formulation And Characterization, Gitanjali Kerkar

Pharmaceutical Sciences

No abstract provided.

Formulation, Optimization And Transungual Penetration Study Of An Antifungal Nail Polish Containing 1% Itraconazole, Sukanya Nagfernandes

Pharmaceutical Sciences

No abstract provided.

Evaluation Of Potassium Status In Heart Failure Patients: A Case Control Study, Sreedharan Nair Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Background: Hyper and hypokalemia is a common ionic imbalance in patient with heart failure. Increased death and hospital stay is common in patients with HF and chronic kidney disease (CKD) who have hypokalaemia. The majority of the intracellular cation is potassium which is necessary to retain a normal charge difference between the intracellular and extracellular spaces. It often happens as a complication of certain diseases or drugs. As hyper or hypokalaemia are potentially hazardous and frequent complication in heart failure patient it is important to identify patients who are at increased risk for hypo and hyperkalaemia. Objectives: The objective of …

"Associations Of Qol, Socioeconomic Status And Health Insurance Type Among Patients With End-Stage Renal Disease: Association With Outcomes.", Prasanna Kumar Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Background: HRQOL, socioeconomic status (SES) factors andpenetration ofinsurance play a main role in affecting the patients’ QOL and the diseased population is linked with increased prevalence of end stage kidneydisease in view of disease progression in chronic kidney disease (CKD). However, not much studies were performed in India with respect to QOL, SES factors and insurance in ESKD patients.Objective: To investigate the association of SES and health insurance type in ESKD patients with maintenance HD and non-dialysis patients, and also to investigate the QOL in them.Methodology:A prospective study was performed on ESKD patients with dialysis and without dialysis in nephrology …

Glycosaminoglycans And Glycosaminoglycan Mimetics In Cancer And Inflammation, Shravan Morla

Medicinal Chemistry Publications

Glycosaminoglycans (GAGs) are a class of biomolecules expressed virtually on all mammalian cells and usually covalently attached to proteins, forming proteoglycans. They are present not only on the cell surface, but also in the intracellular milieu and extracellular matrix. GAGs interact with multiple ligands, both soluble and insoluble, and modulate an important role in various physiological and pathological processes including cancer, bacterial and viral infections, inflammation, Alzheimer’s disease, and many more. Considering their involvement in multiple diseases, their use in the development of drugs has been of significant interest in both academia and industry. Many GAG-based drugs are being developed …

Role Of Cytochrome P450 2b6 Polymorphisms In Unexpected Methadone Death, Taha Ahmad

Theses, Dissertations and Capstones

Methadone is a synthetic, long-acting opioid prescribed as an analgesic for chronic pain. It has a single chiral center forming two enantiomers, (R)-methadone and (S)-methadone, each having specific pharmacological actions. Concentrations of (R)- and (S)-methadone above therapeutic levels have the ability to cause serious, life-threatening, and fatal side effects. Cardiotoxicity is caused by elevated (S)-methadone levels by prolonging the QT interval of the heart’s electrical cycle. In 2014, methadone accounted for only 1% of all opioids prescribed for pain, but was responsible for 3,400 of the 14,838 individuals (~23%) who died in the United States from overdoses due to prescription …

Development Of Targeted Alpha Particle Therapy For Solid Tumors, Narges K. Tafreshi, Michael L. Doligalski, Christopher J. Tichacek, Darpan N. Pandya, Mikalai M. Budzevich, Ghassan El-Haddad, Nikhil I. Khushalani, Eduardo G. Moros, Mark L. Mclaughlin, Thaddeus J. Wadas, David L. Morse

Faculty & Staff Scholarship

Abstract: Targeted alpha-particle therapy (TAT) aims to selectively deliver radionuclides emitting α-particles (cytotoxic payload) to tumors by chelation to monoclonal antibodies, peptides or small molecules that recognize tumor-associated antigens or cell-surface receptors. Because of the high linear energy transfer (LET) and short range of alpha (α) particles in tissue, cancer cells can be significantly damaged while causing minimal toxicity to surrounding healthy cells. Recent clinical studies have demonstrated the remarkable efficacy of TAT in the treatment of metastatic, castration-resistant prostate cancer. In this comprehensive review, we discuss the current consensus regarding the properties of the α-particle-emitting radionuclides that are potentially …

Smoking Cessation Treatments Varenicline (Chantix®️), Nrts, And Nicotine Dependence, Marley Vea Devoss

Biology: Student Scholarship & Creative Works

Varenicline was approved in 2006 by the FDA as an effective smoking cessation drug. Varenicline was designed to bind with α4β2 nicotinic acetylcholine receptors (nAChR) to work as both an agonist and antagonist. Other drugs like nicotine replacement therapies (NRTs) have also contributed to the decreasing rate of active smokers in the United States. The mechanisms of varenicline and its role in addiction are reviewed in this paper. With NRTs and recent trends in electronic smoking devices, nicotine dependence is still a cause for concern due to studies connecting nicotine with cell proliferation and heart disease.

Constituents Of Talisia Nervosa With Potential Utility Against Metabolic Syndrome, Yelkaira Vásquez, Jianping Zhao, Shabana I. Khana, Mahabir P. Gupta, Ikhlas A. Khana

Faculty and Student Publications

© 2019, The Author(s). As coral cover has declined on Caribbean reefs, space has become occupied by other benthic taxa, including sponges, which may affect the recruitment of new corals, thereby affecting the ability of reefs to recover to coral-dominated states. Sponges may inhibit coral recruitment by pre-empting potential recruitment space, overgrowing recruits, or through allelopathy. This study examined coral recruitment across six coral reef sites surrounding St. Thomas, US Virgin Islands, and the impact of one species of sponge and the sponge community as a whole on coral recruitment. To test the effect of a single species of sponge …

Schinus Molle: Anatomy Of Leaves And Stems, Chemical Composition And Insecticidal Activities Of Volatile Oil Against Bed Bug (Cimex Lectularius), Camila D. Machado, Vijayasankar Raman, Junaid U. Rehman, Beatriz H.L.N.S. Maia, Emanuelle K. Meneghetti, Valter P. Almeida, Rosi Z. Silva, Paulo V. Farago, Ikhlas A. Khan, Jane M. Budel

Faculty and Student Publications

© 2019 by the authors The investigation of the constituents that were isolated from Turnera diffusa (damiana) for their inhibitory activities against recombinant human monoamine oxidases (MAO-A and MAO-B) in vitro identified acacetin 7-methyl ether as a potent selective inhibitor of MAO-B (IC50 = 198 nM). Acacetin 7-methyl ether (also known as 5-hydroxy-40, 7-dimethoxyflavone) is a naturally occurring flavone that is present in many plants and vegetables. Acacetin 7-methyl ether was four-fold less potent as an inhibitor of MAO-B when compared to acacetin (IC50 = 50 nM). However, acacetin 7-methyl ether was >500-fold selective against MAO-B over MAO-A as compared …

Fancd2-Deficient Hematopoietic Stem And Progenitor Cells Depend On Augmented Mitochondrial Translation For Survival And Proliferation, Srinivas Chatla, Wei Du, Andrew F. Wilson, Amom Ruhikanta Meetei, Qishen Pang

Faculty & Staff Scholarship

Members of the Fanconi anemia (FA) protein family are involved in multiple cellular processes including response to DNA damage and oxidative stress. Here we show that a major FA protein, Fancd2, plays a role in mitochondrial biosynthesis through regulation of mitochondrial translation. Fancd2 interacts with Atad3 and Tufm, which are among the most frequently identified components of the mitochondrial nucleoid complex essential for mitochondrion biosynthesis. Deletion of Fancd2 in mouse hematopoietic stem and progenitor cells (HSPCs) leads to increase in mitochondrial number, and enzyme activity of mitochondrion-encoded respiratory complexes. Fancd2 deficiency increases mitochondrial protein synthesis and induces mitonuclear protein imbalance. …

Ros Promote Epigenetic Remodeling And Cardiac Dysfunction In Offspring Following Maternal Engineered Nanomaterial (Enm) Exposure, Amina Kunovac, Quincy A. Hathaway, Mark V. Pinti, William T. Goldsmith, Andrya J. Durr, Garret K. Fink, Timothy R. Nurkiewicz, John M. Hollander

Faculty & Staff Scholarship

Background: Nano-titanium dioxide (nano-TiO2) is amongst the most widely utilized engineered nanomaterials (ENMs). However, little is known regarding the consequences maternal ENM inhalation exposure has on growing progeny during gestation. ENM inhalation exposure has been reported to decrease mitochondrial bioenergetics and cardiac function, though the mechanisms responsible are poorly understood. Reactive oxygen species (ROS) are increased as a result of ENM inhalation exposure, but it is unclear whether they impact fetal reprogramming. The purpose of this study was to determine whether maternal ENM inhalation exposure influences progeny cardiac development and epigenomic remodeling. Results: Pregnant FVB dams were exposed to nano-TiO2 …

Real-World Treatment Patterns And Adverse Events In Metastatic Renal Cell Carcinoma From A Large Us Claims Database, Sumata Pal, Jun Gong, Shivani K. Mhatre, Andy Surinach, Sarika Ogale, Rini Vohra, Herschel Wallen, Daniel George

Faculty & Staff Scholarship

Background: Vascular endothelial growth factor (VEGF), tyrosine kinase (TK) and mechanistic target of rapamycin kinase (mTOR) inhibitors are common first-line (1 L) treatments for metastatic renal cell carcinoma (mRCC). Despite treatment availability, the 5-year survival rate in patients diagnosed at the metastatic stage is only ≈ 10%. To gain contemporary insights into RCC treatment trends that may inform clinical, scientific and payer considerations, treatment patterns and adverse events (AEs) associated with 1 L therapy were examined in a retrospective, longitudinal, population-based, observational study of patients with mRCC. Methods: US administrative claims data (Truven Health MarketScan Commercial Databases) were used to …

A Role For Regulator Of G Protein Signaling-12 (Rgs12) In The Balance Between Myoblast Proliferation And Differentiation, Adam B. Schroer, Junaith S. Mohamed, Melinda D. Wilard, Vincent Setola, Emily Oesteich, David P. Siderovski

Faculty & Staff Scholarship

• Regulators of G Protein Signaling (RGS proteins) inhibit G protein-coupled receptor (GPCR) signaling by accelerating the GTP hydrolysis rate of activated Gα subunits. Some RGS proteins exert additional signal modulatory functions, and RGS12 is one such protein, with five additional, functional domains: a PDZ domain, a phosphotyrosine-binding domain, two Ras-binding domains, and a Gα·GDP-binding GoLoco motif. RGS12 expression is temporospatially regulated in developing mouse embryos, with notable expression in somites and developing skeletal muscle. We therefore examined whether RGS12 is involved in the skeletal muscle myogenic program. In the adult mouse, RGS12 is expressed in the tibialis anterior (TA) muscle, …

Development Of A Cx46 Targeting Strategy For Cancer Stem Cells, Erin E. Mulkeans-Hubert, Luke A. Torre-Healy, Daniel J, Silver, Jennifer T. Eurich, Defne Bayik, Emily Serbinowski, Masahiro Hitomi, John Zhou, Bartlomiej Przychodzen, Renliang Zhang, Samuel A. Sprowls, James S. Hale, Tyler J. Alban, Artem Berezovsky, Brent A. Bell, Paul R. Lockman, Babal K. Jha, Justin D. Lathia

Faculty & Staff Scholarship

Gap-junction-mediated cell-cell communication enables tumor cells to synchronize complex processes. We previously found that glioblastoma cancer stem cells (CSCs) express higher levels of the gap junction protein Cx46 compared to non-stem tumor cells (non-CSCs) and that this was necessary and sufficient for CSC maintenance. To understand the mechanism underlying this requirement, we use point mutants to disrupt specific functions of Cx46 and find that Cx46-mediated gap-junction coupling is critical for CSCs. To develop a Cx46 targeting strategy, we screen a clinically relevant small molecule library and identify clofazimine as an inhibitor of Cx46-specific cell-cell communication. Clofazimine attenuates proliferation, self-renewal, and …

Crystal Structure Of The Mitochondrial Protein Mitoneet Bound To A Benze-Sulfonide Ligand, Werner J. Geldenhuys, Timothy E. Long, Pushkar Saralkar, Toshio Iwasaki, Rasia A. A. Nuñez, Rajesh R. Nair, Mary E. Konkle, Michael A. Menze, Mark V. Pinti, John M. Hollander, Lori A. Hazlehurst, Aaron R. Robart

Faculty & Staff Scholarship

MitoNEET (gene cisd1) is a mitochondrial outer membrane [2Fe-2S] protein and is a potential drug target in several metabolic diseases. Previous studies have demonstrated that mitoNEET functions as a redox-active and pH-sensing protein that regulates mitochondrial metabolism, although the structural basis of the potential drug binding site(s) remains elusive. Here we report the crystal structure of the soluble domain of human mitoNEET with a sulfonamide ligand, furosemide. Exploration of the high-resolution crystal structure is used to design mitoNEET binding molecules in a pilot study of molecular probes for use in future development of mitochondrial targeted therapies for a wide variety …

Metabolic Modulation Predicts Heart Failure Tests Performance, Daniel Contaifer Jr., Leo F. Buckley, George Wohlford, Naren G. Kumar, Joshua M. Morriss, Asanga D. Ranasinghe, Salvatore Carbone, Justin M. Canada, Cory Trankle, Antonio Abbate, Benjamin W. Van Tassell, Dayanjan S. Wijesinghe

Pharmacotherapy and Outcomes Science Publications

The metabolic changes that accompany changes in Cardiopulmonary testing (CPET) and heart failure biomarkers (HFbio) are not well known. We undertook metabolomic and lipidomic phenotyping of a cohort of heart failure (HF) patients and utilized Multiple Regression Analysis (MRA) to identify associations to CPET and HFBio test performance (peak oxygen consumption (Peak VO₂), oxygen uptake efficiency slope (OUES), exercise duration, and minute ventilation-carbon dioxide production slope (VE/VCO₂ slope), as well as the established HF biomarkers of inflammation C-reactive protein (CRP), beta-galactoside-binding protein (galectin-3), and N-terminal prohormone of brain natriuretic peptide (NT-proBNP)). A cohort of 49 patients with …

Efficacy Of Sodium Polystyrene Sulfonate In Hyperkalemia, Rajandeep Kaur Pharmd, Dustin D Linn Pharmd, Bcps, Bcccp

Parkview Pharmacy Department

Poster Presentation

Background:

Clinically significant hyperkalemia, defined as potassium ≥ 6.0 mEq/L can be a life-threatening, and urgent lowering of serum potassium is needed to prevent life-threatening arrhythmias. There are many potential causes of hyperkalemia including acute or chronic kidney disease, medications (e.g. ACE-inhibitors), and rhabdomyolysis among other causes.

Market Claims And Efficacy Information In Direct‐To‐Consumer Prescription Drug Print Advertisements, Kathryn J. Aikin Phd, Kevin R. Betts Phd, Aysha Keisler Phd, Kathryn Schaefer Ziemer Phd

United States Food and Drug Administration: Publications

This study examined the impact of “New” and “#1 Prescribed” market claims and quantitative efficacy information on perceptions of a hypothetical prescription drug in a direct‐to‐consumer (DTC) print advertisement. We examined two market claims (New and #1 Prescribed), two efficacy levels (higher and lower), and a control condition without this information. Participants with diabetes were randomized to review one ad version and asked their perceptions of the ad's message, the drug's benefits, side effects and risks, doctors' opinions about the drug, and behavioral intention to use the drug, as well as recall and recognition of drug benefits and risks. Results …

Youth Perception Of Harm And Addictiveness Of Tobacco Products: Findings From The Population Assessment Of Tobacco And Health Study (Wave 1), David R. Strong, Karen Messer, Martha White, Yuyan Shi, Madison Noble, David B. Portnoy, Alexander Persoskie, Annette R. Kaufman, Kelvin Choi, Charles Carusi, Maansi Bansal-Travers, Andrew Hyland, John Pierce

United States Food and Drug Administration: Publications

Purpose: We provide a US national assessment of youth perceptions of the harm and addictiveness of six separate tobacco products, identifying a continuum of perceived harm associated with a range of products in relation to patterns of current use, former use, and susceptibility to use tobacco products.

Methods: We evaluated youth respondents (N=13,651) ages 12–17 from Wave 1 (2013–2014) of the Population Assessment of Tobacco and Health (PATH) Study. Analyses (2015–2016) focused on refining mea- sures of perceived harm for each product and delineating youth characteristics (demographic, tobacco use status) associated with beliefs about the harmfulness and addictiveness of tobacco …

Associations Of Risk Factors Of E-Cigarette And Cigarette Use And Susceptibility To Use Among Baseline Path Study Youth Participants (2013–2014), Michael D. Sawdey, Hannah R. Day, Blair Coleman, Lisa D. Gardner, Sarah E. Johnson, Jean Limpert, Hoda T. Hammad, Macieji L. Goniewicz, David B. Abrams, Cassandra A. Stanton, Jennifer L. Pearson, Annette R. Kaufman, Heather L. Kimmel, Cristine D. Delnevo, Wilson M. Compton, Maansi Bansal-Travers, Raymond S. Niaura, Andrew Hyland, Bridget K. Ambrose

United States Food and Drug Administration: Publications

Introduction: Improved understanding of the distribution of traditional risk factors of cigarette smoking among youth who have ever used or are susceptible to e-cigarettes and cigarettes will inform future longitudinal studies examining transitions in use.

Methods: Multiple logistic regression analysis was conducted using data from youth (ages 12–17 years) who had ever heard of e-cigarettes at baseline of the PATH Study (n = 12,460) to compare the distribution of risk factors for cigarette smoking among seven mutually exclusive groups based on ever cigarette/e-cigarette use and sus- ceptibility status.

Results: Compared to committed never users, youth susceptible to e-cigarettes, cigarettes, or …

Selection And Consumption Of Lunches By National School Lunch Program T Participants, Janet G. Peckham, Jaclyn D. Kropp, Thomas A. Mroz, Vivian Haley-Zitlin, Ellen M. Granberg

United States Food and Drug Administration: Publications

The Healthy, Hunger-Free Kids Act of 2010 requires schools participating in the National School Lunch Program (NSLP) to offer a variety of healthy food options each day. Using digital photography data collected from two suburban elementary schools in the spring of 2013, we examine NSLP participant's selection and consumption of all five NSLP lunch components ((1) milk, (2) vegetable, (3) fruit, (4) meat/meat alternate (MA), and (5) grain). We use logit regressions to analyze the selection of the various lunch components by race/ethnicity, gender, grade, and household income level. In addition, ordinary least squares regressions are used to analyze the …