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Oncolog, Volume 41, Number 02, April-June 1996, Kathryn L. Hale, Stephanie P. Deming

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• lntraoperative lymphatic mapping elegant way to identify lymph node metastases in melanoma patients
• New Patient Referral Office changes with M. D. Anderson's referral policy
• Combined chemotherapy and radiation therapy bringing hope for inoperable lung cancer

Oncolog, Volume 41, Number 03, July-September 1996, Maureen E. Goode, Vickie J. Williams

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• M. D. Anderson researchers stress importance of annual colorectal cancer screening
• Informed consent explains concerns about genetic testing
• New program focuses on inherited predisposition to breast and ovarian cancer

Oncolog, Volume 41, Number 01, January-March 1996, Stephanie P. Deming, Kathryn L. Hale, Vickie J. Williams

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Malignant brain tumors a new target for gene therapy
• Benign pituitary tumors threaten endocrine and nervous systems
• New guidebook helps patients and caregivers cope with advanced cancer

Studies On Ara-C-Induced Dna Damage And Apoptosis In Acute Myeloid Leukemia Cells Which Overexpress P26bcl-2, Gloria Joan Bullock

MUSC Theses and Dissertations

High expression of p26Bcl-2 in patient-derived AML cells has been associated with poor response to chemotherapy including Ara-C. It has been well established that Bcl-2 over expression blocks apoptosis or programmed cell death induced by a wide variety of stimuli including chemotherapeutic drugs. However, the exact mechanism of action of Bcl-2 in promoting this blockade is still largely unknown. To determine the types of Ara-C-induced DNA damage with which Bcl-2 specifically interferes, HL-60/neo and HL-60/Bcl-2 cells were created via retroviral-mediated transfection of the bcl-2 gene. These transfectants served as in vitro AML cell models that expressed different levels of p26Bcl-2. …

Localized Tuberculosis And Myelofibrosis With Myeloid Metaplasia : An Extremely Unusual Presentation, Suhail Muzaffar

Department of Pathology and Laboratory Medicine

Myelofibrosis with myeloid metaplasia (MMM) is usually considered primary agnogenic, however, it may be secondary to various diseases, The association of tuberculosis with MMIM is exceedingly rare, however, the pathogenetic relationship between the two is difficult to define. We present a case report showing simultaneous presentation of localized active tuberculosis and MMM The literature on the subject is also reviewed with special emphasis on pathogenic relation­ship between the two.

Nutritional Problems And Information Needs Of Patients Receiving Chemotherapy And Radiation Therapy, Margaret Joan Robinson

Theses : Honours

Nutritional status is a major factor in determining the successful outcome of treatment for cancer. The combined effect of cancer, and the treatment for cancer, has the potential to severely impair nutritional status. The purpose of this study was to investigate the incidence and severity of treatment-related side-effects which affect nutritional status in cancer patients and to determine the sources and helpfulness of information about nutrition which had been utilised by patients. A descriptive study was used to investigate two groups of patients, one group who was receiving chemotherapy, and the other, radiation therapy. A questionnaire developed by the researcher …

Phase Ia/Ib Trial Of Anti-Gd2 Chimeric Monoclonal Antibody 14.18 (Ch L4.18) And Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (Rhgm-Csf) In Metastatic Melanoma, James Murray, Eugenie Kleinerman, Shu-Fang Jia, Michael Rosenblum, Omar Eton, Antonio Buzaid, Sewa Legha, Merrick Ross, Lora Thompson, Mansoor Saleh

Haematology and Oncology, East Africa

We performed a phase Ia/Ib trial of chimeric anti-GD2 monoclonal antibody 14.18 (ch14.18) in combination with recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) to determine the maximum tolerated dose as well as immunologic and biologic responses to the regimen. Sixteen patients with metastatic malignant melanoma received escalating doses of ch14.18 (15-60 mg/m2) administered intravenously for 4 h on day 1. Twenty-four hours later, subcutaneous injections of rhGM-CSF were administered daily for a total of 14 days. Significant side effects were related to ch14.18 infusion and consisted of moderate to severe abdominal and/or extremity pain, blood pressure changes, headache, nausea, diarrhea, peripheral …

Knowledge, Sources Used And Factors Considered In The Surgical Treatment Decisions Of Women With Breast Cancer, Debra J. Bisel

Masters Theses

The purpose of this replication study was to examine how women with breast cancer reached their decision for surgical treatment (Ward, Heidrich and Wolberg 1989). Twenty-one women who met the surgical criteria, i.e. option for Breast Conserving surgery or Modified Radical Mastectomy, completed four surveys 1 to 7 days post operatively. The women were divided into two groups, 13 who had Breast Conserving surgery and 8 who had Modified Radical Mastectomy. The surveys assessed demographic characteristics of the groups, the level of knowledge regarding breast cancer, factors considered important in reaching the decision for surgery and the sources of information …

Three Dimensional Localization Of Lesions From Digitized Mammograms, Amy L. Magnus

Theses and Dissertations

This thesis describes new algorithms to localize regions-of-interests (ROIs) three dimensionally from a pair of digitized mammograms. This work is intended to add a layer of sophistication to computer aided diagnosis by putting to use the fixed and measurable parameters of mammographic imaging. The fixed parameters are the source to film orientation and the podium-image distance. Measurable parameters are the rotation angle of the x-ray tube from the horizontal and the compression depth (the distance from compression paddle to contact podium distance) at the time of imaging. As an additional benefit, three dimensional localization algorithms alleviate the confusion radiologists may …

Biochemical And Molecular Characterization Of The Prostate-Specific Membrane Antigen (Psma), John Karl Troyer

Theses and Dissertations in Biomedical Sciences

Prostate cancer is the most common malignancy and the second leading cause of cancer death in males in the United States. Additionally, the number of deaths attributed to prostate cancer is increasing at a rate of approximately 8% a year. Development of new diagnostic and therapy strategies are needed in order to improve the life expectancy of patients with this disease. One tool which may allow for improvements in prostate cancer diagnosis and therapy is the monoclonal antibody (MAb) 7E11-C5.3 which was first described in 1987. Since then, the antigen recognized by MAb 7E11-C5.3 has been named the prostate specific …

Primary Amyloidosis Of Gut Presenting With Dysphagia, Zaigham Abbas, Shahab Abid, Naim -Ur- Rehman, Shahid Pervez

Department of Pathology and Laboratory Medicine

No abstract provided.

Identification Of An Idiotypic Peptide Recognized By Autoantibodies In Human Immunodeficiency Virus-1-Infected Individuals, Q. L. Wang, H.-T. Wang, Edwin Blalock, Sybille Müller, Heinz Köhler

Markey Cancer Center Faculty Publications

Antibodies against HIV-1 proteins in HIV-1-infected individuals share a cross-reactive idiotype defined by the monoclonal antiidiotypic antibody 1F7 (5). Using a computer algorithm based on the molecular recognition theory, regions of inverse hydropathy between the variable sequence of 1F7 and human monoclonal anti-HIV-1 antibodies were identified, which are assumed to be involved in idiotype-antiidiotype contacts. A peptide was designed from the proposed contact in the variable heavy chain framework 3-complementarity determining region 3 (FR3-CDR3) of human antibodies and was synthesized. This peptide is recognized by the antiidiotype 1F7 and inhibits the binding of 1F7 to human anti-HIV-1 antibodies which express …

Astrocytes Derived From P53-Deficient Mice Provide A Multistep In Vitro Model For Development Of Malignant Gliomas., Alan M. Yahanda Md, Facs, J M Bruner, L A Donehower, R S Morrison

PCI Publications and Projects

Loss or mutation of p53 is thought to be an early event in the malignant transformation of many human astrocytic tumors. To better understand the role of p53 in their growth and transformation, we developed a model employing cultured neonatal astrocytes derived from mice deficient in one (p53 +/-) or both (p53 -/-) p53 alleles, comparing them with wild-type (p53 +/+) cells. Studies of in vitro and in vivo growth and transformation were performed, and flow cytometry and karyotyping were used to correlate changes in growth with genomic instability. Early-passage (EP) p53 -/- astrocytes achieved higher saturation densities and had …

Immune Response To The Carcinoembryonic Antigen In Patients Treated With An Anti-Idiotype Antibody Vaccine, Kenneth A. Foon, Mala Chakraborty, William J. John, Amanda Sherratt, Heinz Köhler, Malaya Bhattacharya-Chatterjee

Markey Cancer Center Faculty Publications

We have generated an IgG1 murine monoclonal anti-idiotype antibody (Ab2) designated 3H1, which mimics a specific epitope on the carcinoembryonic antigen (CEA). Patients with CEA positive tumors are immunologically "tolerant" to CEA. We used 3H1 as a surrogate for CEA for vaccine therapy of 12 patients with advanced colorectal cancer. Each of the patients received a minimum of four intracutaneous injections of aluminum hydroxide precipitated 3H1 at either 1, 2, or 4 mg dosage per injection. 9 of 12 patients demonstrated anti-anti-idiotypic (Ab3) response to 3H1. All nine patients generated specific anti-CEA antibody demonstrated by reactivity with radiolabeled purified CEA; …

Mathematical Models Of Chemotherapy, John Carl Panetta

Mathematics & Statistics Theses & Dissertations

Several mathematical models are developed to describe the effects of chemotherapy on both cancerous and normal tissue. Each model is defined by either a single homogeneous equation or a system of heterogeneous equations which describe the states of the normal and/or cancer cells. Periodic terms are added to model the effects of the chemotherapy. What we obtain are regions, in parameter space (dose and period), of acceptable drug regimens.

The models take into account various aspects of chemotherapy. These include, interactions between the cancer and normal tissue, cell specific chemotherapeutic drug, the use of non-constant parameters to aid in modeling …

Severe Thrombocytopenia In A Man With Prostatic Cancer, Saeed Hamid, Ata Khan, Haleem Khan, Roger Sutton, Ikram A. Burney, Mohammad Khurshid

Department of Medicine

A 66 year old gentleman was diagnosed to have metastatic adenocarcinoma of the prostate in 1990, following a CT scan of the abdomen and trans-uretheral resection of prostate (TLJRP). He was started on estrogen therapy (Fos­festerol sodium). Two years later he presented to the emer­gency room with breathlessness and edema of the left ann of a week’s duration. He admitted to persistence of symptoms of pmstatism and was found to have bilateral axillary lymphade­nopathy and pitting edema of the left arm. A doppler scan revealed left subclavian vein thrombosis. The patient was started on i.v. heparin and was maintained on …

Loss Of The Tumor Suppressor Genes P53 And Brca1 In Prophylactic Mastectomy Cancer Patients, Garrett Griffith Losh

Presidential Scholars Theses (1990 – 2006)

More importantly, this study has shown that prophylactic mastectomy surgery is a viable and worthwhile treatment to prevent breast cancer recurrence. It is hoped that this information will increase the knowledge of breast cancer. For the same reason, this paper has attempted to explain what cancer is while describing how the genetics of a person cause or contribute to its development. Most of all, it is hoped that this paper will emphasize the severity of this disease in the United States today and tomorrow .

Oncolog, Volume 40, Number 02, April-June 1995, Margaret E. Goode, Vickie` J. Williams, Sunita Patterson

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Creative strategies key in fight against liver cancer
• Getting patients home and back to their routines more quickly
• Teaching physicians how to prevent cancer

Oncolog, Volume 40, Number 03, July-September 1995, Kathryn L. Hale, Vickie` J. Williams, Sunita Patterson

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• M. D. Anderson leads the fight against bone pain from metastatic cancer
• New computer program enhances the surgeon-patient consultation
• Bladder cancer: molecular markers may guide treatment

Oncolog, Volume 40, Number 04, October-December 1995, Kathryn L. Hale, Vickie J. Williams

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Psychiatry at M. D. Anderson: Helping patients learn to live with cancer
• Technology and cooperation powerful tools in locating genes
• Second opinion clinic helps patients get the best treatment

Oncolog, Volume 40, Number 01, January-March 1995, Stephanie P. Deming, Kathryn L. Hale, Linda N. Eppich

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Genetic testing: a new paradigm for medullary thyroid carcinoma
• Bone marrow transplantation now available as an outpatient procedure
• Adjuvant chemotherapy for breast cancer: 20 years of progress at M. D. Anderson

Effect Of Alcohol On The Postnatal Development Of Cerebellar Cortex In Rat Ii: Ultrastructural Study, Mansoor Saleh, Saadia Sayed, Entesar Saber

Haematology and Oncology, East Africa

In The present work, it was found that alcohol produced distinct changes in both Purkinje and granule cells during postnatal development. On the fifth day, the apical cones of the Purkinje cells were less developed and the cells showed an occasional somnatic spines but no somatic processes. At 21 days and adult stage these cells including their dendrites showed marked degenerative changes. The nuinber of basket cell axon synapses on Purkinje cell soma was reduced. There was also a reduction in the amount of basket fibers contributing to the pinceau around the intial seginent of the Purkinje cell axons. The …

A Logistic Model Of Periodic Chemotherapy, J. C. Panetta

Mathematics & Statistics Faculty Publications

A logistic differential equation with a time-varying periodic parameter is used to model the growth of cells, in particular cancer cells, in the presences of chemotherapeutic drugs. The chemotherapeutic effects are modeled by a periodic parameter that modifies the growth rate of the cell tissue. A negative growth rate represents the detrimental effects of the drugs. A simple criterion is obtained for the behavior of the chemotherapy.

Phase Ii Trial Of Murine Monoclonal Antibody D612 Combined With Recombinant Human Monocyte Colony-Stimulating Factor (Rhm-Csf) In Patients With Metastatic Gastrointestinal Cancer, Mansoor Saleh, Michael Khazaeli, Richard Wheeler, Pat Bucy, Tiepe Liu, Michael Everson, David Mun, Jeff Schlom

Haematology and Oncology, East Africa

In a Phase II study, 14 patients with metastatic gastrointestinal cancer received the mAb D612 (40 mg/m2, days 4, 7, and 11) in combination with recombinant human monocyte colony-stimulating factor [(rhM-CSF) 80 ug/kg/days 1-14]. The combined treatment was well tolerated and resulted in characteristic biological activity associated with each of the agents. Thus, 10 of 14 patients experienced D612-associated secretory diarrhea, which responded to the prostaglandin inhibitor Indomethacin in 5 of 7 patients. rhM-CSF therapy was associated with peripheral mono- cytosis (peak absolute monocyte count, 1444 ±394/mm3) and thrombocytopenia (nadir count, 78 ±10/nim '). Monocyte surface marker analysis revealed a …

Cd16+ Monocytes In Patients With Cancer: Spontaneous Elevation And Pharmacologic Induction By Recombinant Human Macrophage Colony- Stimulating Factor, Mansoor Saleh, Goldman Samuel, Lobuglio Albert, Beall Arthur, Sabio Hernan, Mccord Melissa, Minasian Lori, Alpaugh Katherine, Weiner Louis, Munn David

Haematology and Oncology, East Africa

The small subset of circulating monocytes that express the maturation- associated CD16 antigen has recently been reported to be elevated in patients with bacterial sepsis. We now show that this novel CD16+ monocyte population is also spontaneously expanded in patients with cancer. We studied 14 patients with metastatic gastrointestinal carcinoma enrolled in a clinical trial of recombinant human macrophage colony-stimulating factor (rhMCSF) plus monoclonal antibody D612. We found that before any cytokine treatment, 12 of 14 patients constitutively displayed significant elevations in both the percentage and the absolute number of CD16+ monocytes, as compared with both normal subjects and ill …

Development Of A Mammographic Image Processing Environment Using Matlab, John L. Kelley

Theses and Dissertations

Breast cancer is a disease that accounts for a disturbingly large number of deaths in females each year. Its prevalence is a topic of concern to all of us since it can affect our families, friends, and coworkers. Although mammographic screening is the most effective method currently available for the early detection of breast cancer, it is far from being an infallible procedure. Mammographic reading is error prone, partly because of the complexity of the task and partly because of the variability in human performance. Computers offer high reproducibility, and when used as an adjunct by the radiologist, may improve …

Immunohistochemical Estrogen Receptor Determination In Human Breast Carcinoma: Correlation With Histologic Differentiation And Age Of The Patients, Shahid Pervez, S. Shaikh, F. Aijaz, S. A. Aziz, M. Naqvi, Sheema H. Hasan

Department of Pathology and Laboratory Medicine

An immunohistochemical assay for the measurement of estrogen receptor (ER) has been evaluated on 290 consecutive human breast biopsy and mastectomy specimens in the year 1992 at The Aga Khan University Hospital laboratories. Immunohistochemical localization of estrogen receptor on frozen/paraffin section was scored in a semi-quantitative fashion incorporating both the intensity and the distribution of specific staining. Histologic grading of the tumour was performed according to Bloom’s method. In this study, 21% of the tumours were estrogen receptor negative, 15% were weak positive, 25% intermediate positive and 39% strong positive. Fifty percent of the well differentiated tumours showed strong ER …

Oncolog, Volume 39, Number 03, July-September 1994, Kimberly J. T. Herrick, Sunita Patterson

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Familial cancer syndromes a focus of cancer genetics research
• New test identifies Philadelphia chromosome-positive leukemias

Oncolog, Volume 39, Number 02, April-June 1994, Vickie J. Williams, Kathryn L. Hale

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Outwitting unknown primary tumors
• Synthetic peptide effectively controls the spread of HIV in human cell cultures
• Biological response modifiers promising adjuvants to cancer therapy

Oncolog, Volume 39, Number 01, January-March 1994, Sunita Patterson, Maureen E. Goode, Kathryn L. Hale

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Liposomal muramyl tripeptide kills bone cancer cells by stimulating the immune system Gene therapy at M. D. Anderson
• Researcher studies the hemopreventive power of garlic