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Toxicology Commons™

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2020

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Articles 1 - 30 of 821

Full-Text Articles in Toxicology

Pharmaceuticals And Personal Care Products In Pacific Northwest Coastal Ecosystems: Spatial Variation, Organism Effects, And Consumer Perspectives, Amy Lynne Ehrhart Dec 2020

Pharmaceuticals And Personal Care Products In Pacific Northwest Coastal Ecosystems: Spatial Variation, Organism Effects, And Consumer Perspectives, Amy Lynne Ehrhart

Dissertations and Theses

Anthropogenic pollution poses a threat to marine organisms and ecosystems worldwide. Common chemical pollutants that enter the marine environment include legacy contaminants, which are well known and heavily regulated or banned pollutants, and emerging contaminants, which are more recently recognized as pollutants and often lack regulatory limits for their use and discharge. Wastewater treatment plant (WWTP) effluent is a major source of various contaminants of concern, particularly pharmaceutical and personal care products (PPCPs) that are not fully removed during treatment. PPCPs exist at low concentrations in the environment and may have unknown and subtle effects on marine life. Data gaps …

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Physicochemical Characterization And Genotoxicity Of The Broad Class Of Carbon Nanotubes And Nanofibers Used Or Produced In Us Facilities, Kelly Fraser, Vamsi Kodali, Naveena Yanamala, M. Eileen Birch, Lorenzo Cena, Gary Casuccio, Kristin Bunker, Traci L. Lersch, Douglas E. Evans, Aleksandr Stefaniak, Mary Ann Hammer, Michael L. Kashon, Theresa Boots, Tracy Eye, John Hubczak, Sherri A. Friend, Matthew Dahm, Mary K. Schubauer-Berigan, Katelyn Siegrist, David Lowry, Alison K. Bauer, Linda M. Sargent, Aaron Erdely Dec 2020

Physicochemical Characterization And Genotoxicity Of The Broad Class Of Carbon Nanotubes And Nanofibers Used Or Produced In Us Facilities, Kelly Fraser, Vamsi Kodali, Naveena Yanamala, M. Eileen Birch, Lorenzo Cena, Gary Casuccio, Kristin Bunker, Traci L. Lersch, Douglas E. Evans, Aleksandr Stefaniak, Mary Ann Hammer, Michael L. Kashon, Theresa Boots, Tracy Eye, John Hubczak, Sherri A. Friend, Matthew Dahm, Mary K. Schubauer-Berigan, Katelyn Siegrist, David Lowry, Alison K. Bauer, Linda M. Sargent, Aaron Erdely

Public Health Sciences Faculty Publications

Background Carbon nanotubes and nanofibers (CNT/F) have known toxicity but simultaneous comparative studies of the broad material class, especially those with a larger diameter, with computational analyses linking toxicity to their fundamental material characteristics was lacking. It was unclear if all CNT/F confer similar toxicity, in particular, genotoxicity. Nine CNT/F (MW #1-7 and CNF #1-2), commonly found in exposure assessment studies of U.S. facilities, were evaluated with reported diameters ranging from 6 to 150 nm. All materials were extensively characterized to include distributions of physical dimensions and prevalence of bundled agglomerates. Human bronchial epithelial cells were exposed to the nine …

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Investigating Dose-Dependent, Multi-Generational, And Strain-Specific Effects Of 17Α-Ethynylestradiol Exposure In Zebrafish (Danio Rerio), Decatur Mitochondria Foster Dec 2020

Investigating Dose-Dependent, Multi-Generational, And Strain-Specific Effects Of 17Α-Ethynylestradiol Exposure In Zebrafish (Danio Rerio), Decatur Mitochondria Foster

Dissertations and Theses

Endocrine disrupting chemicals (EDCs) pose a threat to biodiversity at the individual, population, and ecosystem level, as they can interfere with processes that are responsible for regulating metabolism, development, behavior, and reproduction in living organisms. 17α-ethynylestradiol (EE2) is a synthetic estrogen and EDC utilized in pharmaceutical and livestock industries, and contaminates waterways worldwide. This research explores the effects of dose-dependent and multi-generational exposure of EE2 in three strains of zebrafish. High dose (10-25 ng/L EE2) exposure led to complete reproductive failure, as well as significantly decreased survival and growth. A period in clean water (depuration) after exposure allowed for some …

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Acknowledgment Of Reviewers, Lily Chiu Dec 2020

Acknowledgment Of Reviewers, Lily Chiu

Journal of Food and Drug Analysis

No abstract provided.

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The Analytical And Biomedical Applications Of Carbon Dots And Their Future Theranostic Potential: A Review, Sukunya Ross, Ren-Siang Wu, Shih-Chun Wei, Gareth M. Ross, Huan-Tsung Chang Dec 2020

The Analytical And Biomedical Applications Of Carbon Dots And Their Future Theranostic Potential: A Review, Sukunya Ross, Ren-Siang Wu, Shih-Chun Wei, Gareth M. Ross, Huan-Tsung Chang

Journal of Food and Drug Analysis

In recent years, carbon dots (C-dots) have gained appreciable interest owing to their unique optical properties, including tunable fluorescence, stability against photobleaching and photoblinking, and strong fluorescence. Simple and low-cost hydrothermal and electrochemical approaches have been widely used in the preparation of biocompatible and high-quality C-dots. Various C-dots have been used for the quantitation of small analytes, mostly based on analyte induced fluorescence quenching. Depending on the nature of precursors, synthetic conditions (such as reaction temperature and time), and surface conjugation, multi-function C-dots can be prepared and used in diagnostics and therapeutics. Their strong fluorescence and photostability, enables use in …

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Nanomaterial-Based Adsorbents And Optical Sensors For Illicit Drug Analysis, Chun-Hsien Chen, Chun-Chi Wang, Po-Yun Ko, Yen-Ling Chen Dec 2020

Nanomaterial-Based Adsorbents And Optical Sensors For Illicit Drug Analysis, Chun-Hsien Chen, Chun-Chi Wang, Po-Yun Ko, Yen-Ling Chen

Journal of Food and Drug Analysis

The abuse of illicit drugs has been prevalent in recent years and is associated with crime and public health issues. To strengthen public security and fortify public health services with respect to the increasing severity of drug abuse, academic and government institutes have been devoted to constructing relative analytical methods for illicit drugs. To date, the development of sensors has been greatly emphasized due to their features of high sensitivity, prompt detection and flexible manipulation; thus, sensors can serve as alternatives to conventional sophisticated instruments. Recently, the use of nanomaterials has inspired the development of a series of innovative sample …

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Gold Nanoparticle-Based Colorimetric And Electrochemical Sensors For The Detection Of Illegal Food Additives, Li Li, Ming Zhang, Wei Chen Dec 2020

Gold Nanoparticle-Based Colorimetric And Electrochemical Sensors For The Detection Of Illegal Food Additives, Li Li, Ming Zhang, Wei Chen

Journal of Food and Drug Analysis

Lately, scandals associated with the illegal addition of poisonous chemicals to food for commercial interests have been gradually disclosed to the public. Problems related to food safety do not only harm public health but also affect the stability of economic and social development. Food safety has become a common issue in society, and strengthening the related regulations have become increasingly important. Although conventional techniques are accurate and sensitive in the detection of the vast majority of illegal food additives, they rely on time-consuming, labor-intensive procedures that depend on expensive instruments. Thus, efficient and rapid identification of poisonous, illegal additives in …

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Improved Food Additive Analysis By Ever-Increasing Nanotechnology, Jing Zhang, Shui Hu, Yi Du, Ding Cao, Guirong Wang, Zhiqin Yuan Dec 2020

Improved Food Additive Analysis By Ever-Increasing Nanotechnology, Jing Zhang, Shui Hu, Yi Du, Ding Cao, Guirong Wang, Zhiqin Yuan

Journal of Food and Drug Analysis

Improper use of food additives may lead to potential threat to human health, making it important to develop sensitive and selective method for the detection of them. Nanomaterials with unique chemical and electrochemical properties show extensive applications in the design of food additive sensing systems. In this review, we summarize the recently adopted electrochemical and optical analysis of food additives based on nanomaterials. Detection of typical food additives (colorants and preservatives) by using different sensing mechanisms and strategies are provided. In addition, determination of illegal food additives is also briefly introduced. Finally, this review highlights the challenges and future trend …

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Electrowetting-On-Dielectric (Ewod): Current Perspectives And Applications In Ensuring Food Safety, Snigdha Roy Barman, Imran Khan, Subhodeep Chatterjee, Subhajit Saha, Dukhyun Choi, Sangmin Lee, Zong-Hong Lin Dec 2020

Electrowetting-On-Dielectric (Ewod): Current Perspectives And Applications In Ensuring Food Safety, Snigdha Roy Barman, Imran Khan, Subhodeep Chatterjee, Subhajit Saha, Dukhyun Choi, Sangmin Lee, Zong-Hong Lin

Journal of Food and Drug Analysis

Digital microfluidic (DMF) platforms have contributed immensely to the development of multifunctional lab-on-chip systems for performing complete sets of biological and analytical assays. Electrowetting-on-dielectric (EWOD) technology, due to its outstanding flexibility and integrability, has emerged as a promising candidate for such lab-on-chip applications. Triggered by an electrical stimulus, EWOD devices allow precise manipulation of single droplets along the designed electrode arrays without employing external pumps and valves, thereby enhancing the miniaturization and portability of the system towards transcending important laboratory assays in resource-limited settings. In recent years, the simple fabrication process and reprogrammable architecture of EWOD chips have led to …

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Nanomaterial-Based Fluorescent Biosensor For Veterinary Drug Detection In Foods, Xiaoqi Tao, Yuanyuan Peng, Juewen Liu Dec 2020

Nanomaterial-Based Fluorescent Biosensor For Veterinary Drug Detection In Foods, Xiaoqi Tao, Yuanyuan Peng, Juewen Liu

Journal of Food and Drug Analysis

Veterinary drugs have been widely used in the food industry. Their residues in food products need to be tightly regulated to ensure food safety. In particular, some veterinary drugs are still used illegally, although they have already been banned. Nanomaterials are playing an increasingly important role in analytical chemistry due to their unique properties. Compared to traditional organic dyes and colloidal gold nanoparticle labels, fluorescent nanomaterials appear particularly attractive for the detection of veterinary drug residues. This review summarizes recent advancements of fluorescent biosensors using nanomaterials for the detection of veterinary drug residues in foods. The useful properties of each …

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Carbon Quantum Dots For The Detection Of Antibiotics And Pesticides, Han-Wei Chu, Binesh Unnikrishnan, Anisha Anand, Yang-Wei Lin, Chih-Ching Huang Dec 2020

Carbon Quantum Dots For The Detection Of Antibiotics And Pesticides, Han-Wei Chu, Binesh Unnikrishnan, Anisha Anand, Yang-Wei Lin, Chih-Ching Huang

Journal of Food and Drug Analysis

Carbon quantum dots (CQDs) are novel nanomaterials with interesting physical and chemical properties, which are intensely studied only in the last decade. Unique properties, such as its inherent fluorescent property, high resistance to photobleaching, high surface area, ease of synthesis, flexible choice of precursor, and surface tunability enable CQDs for promising application in biosensing. Therefore, it is highly useful in clinical, forensic, medical, food and drug analyses, disease diagnosis, and various other fields of biosensing. In addition, their fluorescence properties are tunable by the interaction with certain molecules via different mechanisms, which enables their application for sensing of those molecules, …

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Noble Metal Nanomaterial-Based Aptasensors For Microbial Toxin Detection, Yue He, Cong-Ying Wen, Zhi-Jun Guo, Yu-Fen Huang Dec 2020

Noble Metal Nanomaterial-Based Aptasensors For Microbial Toxin Detection, Yue He, Cong-Ying Wen, Zhi-Jun Guo, Yu-Fen Huang

Journal of Food and Drug Analysis

Microbial toxins generated by bacteria, fungi and algae cause serious food-safety problems due to the frequent contamination of foodstuffs and their poisonous nature. Becoming acquainted with the contamination condition of foodstuffs is highly dependent on developing sensitive, specific, and accurate methods for targeting microbial toxins. Aptamers, obtained from systematic evolution of ligands by exponential enrichment (SELEX), have significant advantages for microbial toxin analysis, such as small size, reproducible chemical synthesis, and modification, as well as high binding affinity, specificity, and stability. Besides, aptamers have a predictable structure and can be tailored using biomolecular tools (e.g., ligase, endonuclease, exonuclease, …

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Perspective On Recent Developments Of Nanomaterial Based Fluorescent Sensors: Applications In Safety And Quality Control Of Food And Beverages, Ailing Han, Sijia Hao, Yayu Yang, Xia Li, Xiaoyu Luo, Guozhen Fang, Jifeng Liu, Shuo Wang Dec 2020

Perspective On Recent Developments Of Nanomaterial Based Fluorescent Sensors: Applications In Safety And Quality Control Of Food And Beverages, Ailing Han, Sijia Hao, Yayu Yang, Xia Li, Xiaoyu Luo, Guozhen Fang, Jifeng Liu, Shuo Wang

Journal of Food and Drug Analysis

As the highly toxic pollutants will seriously harm human health, it is particularly important to establish the analysis and detection technology of food pollutants. Compared with the traditional detection methods, fluorescent detection technique based on nanomaterials trigger wide interesting because of reduced detection time, simple operation, high sensitivity and selectivity and economic. In this review, the application of fluorescent sensors in food pollutants detection is presented. Firstly, conventional fluorescent nanomaterials including metal-based quantum dots, carbon-based quantum dots and metal nanoclusters were summarized, with emphasis on the photoluminescence mechanism. Then, the fluorescence sensors based on these nanomaterials for food pollutants detection …

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Preface, Huan-Tsung Chang, Yu-Fen Huang Dec 2020

Preface, Huan-Tsung Chang, Yu-Fen Huang

Journal of Food and Drug Analysis

No abstract provided.

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Assessment Of Grain Safety In Developing Nations, Jose R. Mendoza Dec 2020

Assessment Of Grain Safety In Developing Nations, Jose R. Mendoza

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Grains are the most widely consumed foods worldwide, with maize (Zea mays) being frequently consumed in developing countries where it feeds approximately 900 million people under the poverty line of 2 USD per day. While grain handling practices are acceptable in most developed nations, many developing nations still face challenges such as inadequate field management, drying, and storage. Faulty grain handling along with unavoidably humid climates result in recurrent fungal growth and spoilage, which compromises both the end-quality and safety of the harvest. This becomes particularly problematic where there is little awareness about health risks associated with poor …

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Eelgrass (Zostera Marina) Population Decline In Morro Bay, Ca: A Meta-Analysis Of Herbicide Application In San Luis Obispo County And Morro Bay Watershed, Tyler King Sinnott Dec 2020

Eelgrass (Zostera Marina) Population Decline In Morro Bay, Ca: A Meta-Analysis Of Herbicide Application In San Luis Obispo County And Morro Bay Watershed, Tyler King Sinnott

Master's Theses

The endemic eelgrass (Zostera marina) community of Morro Bay Estuary, located on the central coast of California, has experienced an estimated decline of 95% in occupied area (reduction of 344 acres to 20 acres) from 2008 to 2017 for reasons that are not yet definitively clear. One possible driver of degradation that has yet to be investigated is the role of herbicides from agricultural fields in the watershed that feeds into the estuary. Thus, the primary research goal of this project was to better understand temporal and spatial trends of herbicide use within the context of San Luis …

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Regulation Of In Vitro And In Vivo Hepatic Stellate Cell Activation By The Ayrl Hydrocarbon Receptor, Shivakumar Rayavara Veerabhadraiah Dec 2020

Regulation Of In Vitro And In Vivo Hepatic Stellate Cell Activation By The Ayrl Hydrocarbon Receptor, Shivakumar Rayavara Veerabhadraiah

Boise State University Theses and Dissertations

Liver fibrosis is a pathological condition characterized by the excessive deposition of extracellular matrix material by activated hepatic stellate cells (HSCs). We recently reported that activation of the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increases HSC activation in vitro and in mouse models of experimental liver fibrosis. The goal of this project was to determine the mechanism by which AhR activation impacts HSC activation and the subsequent development of liver fibrosis. It is possible that HSCs are direct cellular targets for TCDD. Alternatively, TCDD could increase HSC activation indirectly by exacerbating hepatocyte damage …

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An Investigation Into The Adverse Effects Of Oxidative Stress From Exposure To Bisphenol A And Its Analogues, Rachel Nas Nov 2020

An Investigation Into The Adverse Effects Of Oxidative Stress From Exposure To Bisphenol A And Its Analogues, Rachel Nas

Senior Honors Theses

Oxidative stress is a physiological event caused by an overaccumulation of reactive oxygen species (ROS) within the body. While ROS are a natural by-product of oxygen metabolism, too many can lead to cell and tissue damage and contribute to many etiologies. Bisphenol A (BPA), a component of many plastic products, has been shown to induce oxidative stress. While the industrial usage of BPA usage has lessened, the safety of its replacements is unknown. This paper will primarily discuss ROS and mechanisms of oxidative stress, the usage of BPA and its analogues, etiologies associated with oxidative stress resulting from exposure to …

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Nutrient Concentration For Cyanotoxins At Turnbull (Proposal), Mori Williams Nov 2020

Nutrient Concentration For Cyanotoxins At Turnbull (Proposal), Mori Williams

2020 McNair Scholar Collection

The purpose of this study is to analyze the concentration of microcystins from cyanobacteria along with factors that increase the likelihood of microcystins found in water systems at the Turnbull National Wildlife Refuge (TNWR) near Cheney, Washington. Cyanobacteria are oxygen-producing bacteria that use sunlight as an energy source to convert CO2 into biomass. This bacterium has been around for around 3 billion years. However, in recent years, cyanobacteria have been a major issue in drinking water and aquatic ecosystems due to eutrophication, rising CO2 levels, and global warming (Huisman et al). Due to anthropogenic sources such as agricultural run-off and …

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Comparison Of Centrifugation And Solid Phase Extraction (Spe) Methods Of Sample Preparations In Determination Of Residues Of Drugs Of Abuse In Urine, John Mahugija, Anastazia Wandwi, Kessy Kilulya Oct 2020

Comparison Of Centrifugation And Solid Phase Extraction (Spe) Methods Of Sample Preparations In Determination Of Residues Of Drugs Of Abuse In Urine, John Mahugija, Anastazia Wandwi, Kessy Kilulya

Tanzania Journal of Science

Detection of drugs of abuse in urine samples depends on their composition, absorption, distribution, physical and chemical properties, concentrations, elimination properties, and the techniques employed. This study compared the performance of centrifugation and solid phase extraction (SPE) methods in the determination of levels of drugs of abuse and their metabolites in urine samples collected from drug abusers. Analysis was performed using liquid chromatography-tandem mass spectrometry (LC-MS-MS). Calibration was done using both internal and external standards. The recovery values were generally greater in centrifugation method than in SPE method, but the recoveries in both methods were within an acceptable range. Linearity …

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Hepatobiliary Polycyclic Aromatic Hydrocarbons In Pelagic Fishes Of The Gulf Of Mexico, Madison R. Schwaab Oct 2020

Hepatobiliary Polycyclic Aromatic Hydrocarbons In Pelagic Fishes Of The Gulf Of Mexico, Madison R. Schwaab

USF Tampa Graduate Theses and Dissertations

Fisheries populations and their ecosystems are negatively impacted by both chronic and acute inputs of pollutants, including oil spills such as the Deepwater Horizon platform blowout in 2010 in the Gulf of Mexico (GoM). After Deepwater Horizon, toxicological studies of demersal fishes of the northern GoM were undertaken to characterize impacts and to establish baseline contaminant levels in the aftermath of the spill. In this study, I quantify polycyclic aromatic hydrocarbon (PAH) concentrations in eight pelagic fish species to demonstrate oil exposure differences between species, region and time. Analysis of biliary PAH metabolite equivalents using high performance liquid chromatography was …

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David S. Miller: Scientist, Mentor, Friend--A Tribute And Thank You, Björn Bauer, J. Larry Renfro, Karl J. Karnaky, Rosalinde Masereeuw, Gert Fricker, Ron E. Cannon, Anika M. S. Hartz Sep 2020

David S. Miller: Scientist, Mentor, Friend--A Tribute And Thank You, Björn Bauer, J. Larry Renfro, Karl J. Karnaky, Rosalinde Masereeuw, Gert Fricker, Ron E. Cannon, Anika M. S. Hartz

Pharmaceutical Sciences Faculty Publications

David S. Miller was Acting Scientific Director of the Division of Intramural Research at the National Institute of Environmental Health Sciences, National Institutes of Health, and Head of the Intracellular Regulation Group in the Laboratory of Toxicology and Pharmacology before he retired in 2016. David received his Ph.D. in biochemistry from the University of Maine in 1973. David was a Group Leader at the Michigan Cancer Foundation before joining the NIEHS in 1985. His research covered a wide range from renal excretory transport mechanisms to regulation of transporters at the blood-CSF and blood-brain barriers, from fish, amphibians and birds to …

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Develop A High-Throughput Screening Method To Identify C-P4h1 (Collagen Prolyl 4-Hydroxylase 1) Inhibitors From Fda-Approved Chemicals, Shike Wang, Kuo-Hao Lee, Nathália Victoria Araujo, Chang-Guo Zhan, Vivek M. Rangnekar, Ren Xu Sep 2020

Develop A High-Throughput Screening Method To Identify C-P4h1 (Collagen Prolyl 4-Hydroxylase 1) Inhibitors From Fda-Approved Chemicals, Shike Wang, Kuo-Hao Lee, Nathália Victoria Araujo, Chang-Guo Zhan, Vivek M. Rangnekar, Ren Xu

Pharmaceutical Sciences Faculty Publications

Collagen prolyl 4-hydroxylase 1 (C-P4H1) is an α-ketoglutarate (α-KG)-dependent dioxygenase that catalyzes 4-hydroxylation of proline on collagen. C-P4H1-induced prolyl hydroxylation is required for proper collagen deposition and cancer metastasis. Therefore, targeting C-P4H1 is considered a potential therapeutic strategy for collagen-related cancer progression and metastasis. However, no C-P4H1 inhibitors are available for clinical testing, and the high content assay is currently not available for C-P4H1 inhibitor screening. In the present study, we developed a high-throughput screening assay by quantifying succinate, a byproduct of C-P4H-catalyzed hydroxylation. C-P4H1 is the major isoform of collagen prolyl 4-hydroxylases (CP4Hs) that contributes the majority prolyl 4-hydroxylase …

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Aluminum Reproductive Toxicity: A Summary And Interpretation Of Scientific Reports, Robert A. Yokel Sep 2020

Aluminum Reproductive Toxicity: A Summary And Interpretation Of Scientific Reports, Robert A. Yokel

Pharmaceutical Sciences Faculty Publications

Publications addressing aluminum (Al)-induced reproductive toxicity were reviewed. Key details were compiled in summary tables. Approximate systemic Al exposure, a measure of bioavailability, was calculated for each exposure, based on the Al percentage in the dosed Al species, Al bioavailability, and absorption time course reports for the exposure route. This was limited to laboratory animal studies because no controlled-exposure human studies were found. Intended Al exposure was compared to unintended dietary Al exposure. The considerable and variable Al content of laboratory animal diets creates uncertainty about reproductive function in the absence of Al. Aluminum-induced reproductive toxicity in female mice and …

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Corrigendum To “Physicochemical Analysis And Nonisothermal Kinetic Study Of Sertralineelactose Binary Mixtures”, Farnaz Monajjemzadeh Aug 2020

Corrigendum To “Physicochemical Analysis And Nonisothermal Kinetic Study Of Sertralineelactose Binary Mixtures”, Farnaz Monajjemzadeh

Journal of Food and Drug Analysis

No abstract provided.

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Corrigendum To “Shenmai-Yin Decreased The Clearance Of Nifedipine In Rats: The Involvement Of Time-Dependent Inhibition Of Nifedipine Oxidation”, Yune- Fang Ueng Aug 2020

Corrigendum To “Shenmai-Yin Decreased The Clearance Of Nifedipine In Rats: The Involvement Of Time-Dependent Inhibition Of Nifedipine Oxidation”, Yune- Fang Ueng

Journal of Food and Drug Analysis

No abstract provided.

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Corrigendum To “The Time-Dependent Effects Of St John's Wort On Cytochrome P450, Uridine Diphosphate-Glucuronosyltransferase, Glutathione S-Transferase, And Nad(P)H-Quinone Oxidoreductase In Mice”, Yune- Fang Ueng Aug 2020

Corrigendum To “The Time-Dependent Effects Of St John's Wort On Cytochrome P450, Uridine Diphosphate-Glucuronosyltransferase, Glutathione S-Transferase, And Nad(P)H-Quinone Oxidoreductase In Mice”, Yune- Fang Ueng

Journal of Food and Drug Analysis

No abstract provided.

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Corrigendum To “Effects Of Aqueous Extract Of Ruta Graveolens And Its Ingredients On Cytochrome P450, Uridine Diphosphate (Udp)-Glucuronosyltransferase, And Reduced Nicotinamide Adenine Dinucleotide (Phosphate) (Nad(P)H)-Quinone Oxidoreductase In Mice”, Yune- Fang Ueng Aug 2020

Corrigendum To “Effects Of Aqueous Extract Of Ruta Graveolens And Its Ingredients On Cytochrome P450, Uridine Diphosphate (Udp)-Glucuronosyltransferase, And Reduced Nicotinamide Adenine Dinucleotide (Phosphate) (Nad(P)H)-Quinone Oxidoreductase In Mice”, Yune- Fang Ueng

Journal of Food and Drug Analysis

No abstract provided.

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Acarbose Attenuates Migration/Proliferation Via Targeting Microrna-143 In Vascular Smooth Muscle Cells Under Diabetic Conditions, Wei-Yuan Chuang, Meng-Hsun Yu, Tsung-Yuan Yang, Kuei-Chuan Chan, Chau-Jong Wang Aug 2020

Acarbose Attenuates Migration/Proliferation Via Targeting Microrna-143 In Vascular Smooth Muscle Cells Under Diabetic Conditions, Wei-Yuan Chuang, Meng-Hsun Yu, Tsung-Yuan Yang, Kuei-Chuan Chan, Chau-Jong Wang

Journal of Food and Drug Analysis

Acarbose (an a-glucosidase inhibitor) has been demonstrated to reduce the progression of atherosclerosis without affecting serum levels of glucose in rabbits fed a high cholesterol diet. The main focus of recent atherosclerosis studies has been microRNA targets. However, the mechanism by which acarbose targets miRNA-mediated atherosclerosis remains unclear. This study aimed to evaluate the effect of acarbose on microRNA-related regulation of rat aortic vascular smooth cell line (A7r5 cell) migration and proliferation induced by diabetic conditions. We reported that acabose exhibit significantly inhibits proliferative and cell migration abilities in A7r5 cells. The expression of protein and levels of mRNA were …

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Effect Of 6,7-Dimethoxy-2,2-Dimethyl-2h-Chromene (Agerarin) On The Recovery Of Filaggrin Expression Through Targeting Of Janus Kinases In The Inflammatory Skin, Sung Shin Ahn, Young Han Lee, Hyunjin Yeo, Youngshim Lee, Do Sik Min, Yoongho Lim, Soon Young Shin Aug 2020

Effect Of 6,7-Dimethoxy-2,2-Dimethyl-2h-Chromene (Agerarin) On The Recovery Of Filaggrin Expression Through Targeting Of Janus Kinases In The Inflammatory Skin, Sung Shin Ahn, Young Han Lee, Hyunjin Yeo, Youngshim Lee, Do Sik Min, Yoongho Lim, Soon Young Shin

Journal of Food and Drug Analysis

Filaggrin (FLG) is a structural component of the stratum corneum that is essential for maintaining the barrier function of the skin and for the formation of natural moisturizing factors. 6,7-Dimethoxy-2,2-dimethyl-2H-chromene (Agerarin) is a bioactive compound derived from Ageratum houstonianum, a plant that is used as a traditional medicine to treat skin diseases. This study aimed to evaluate the effect of agerarin on skin inflammation in a dinitrochlorobenzene (DNCB)-induced atopic dermatitis mouse model. We found that the topical administration of agerarin ameliorates atopic dermatitis-like skin lesions. We also showed that agerarin restores the reduced filaggrin (FLG) expression in …

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