Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Pharmacology (9)
- Medicine and Health Sciences (6)
- Environmental Health (3)
- Neuroscience and Neurobiology (3)
- Physical Sciences and Mathematics (3)
-
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (2)
- Animal Experimentation and Research (2)
- Biochemistry, Biophysics, and Structural Biology (2)
- Chemicals and Drugs (2)
- Ecology and Evolutionary Biology (2)
- Medical Cell Biology (2)
- Medical Sciences (2)
- Microbiology (2)
- Molecular and Cellular Neuroscience (2)
- Plant Sciences (2)
- Public Health (2)
- Research Methods in Life Sciences (2)
- Therapeutics (2)
- Analytical Chemistry (1)
- Anatomy (1)
- Animal Sciences (1)
- Animal Studies (1)
- Applied Mathematics (1)
- Aquaculture and Fisheries (1)
- Behavior and Ethology (1)
- Biochemistry (1)
- Biodiversity (1)
- Institution
- Keyword
-
- Toxicology (3)
- Hippocampus (2)
- Inflammation (2)
- Inhalation (2)
- Nanoparticles (2)
-
- 5HT-1B (1)
- AAV (1)
- Abuse potential (1)
- Acetylcholinesterase (1)
- Adverse drug responses (1)
- Adverse outcome pathway;Artificial intelligence applications;Computational toxicology;Mechanistic modeling;New approach methodologies;Quantitative structure-activity relationship modeling (1)
- Aeromonas hydrophila (1)
- Alcohol (1)
- Antioxidant (1)
- Apoptosis (1)
- Aporphines (1)
- Astrocytes (1)
- Autophagy (1)
- Autoreceptor (1)
- BET inhibitors (1)
- Bioanalysis (1)
- Boldine (1)
- Butyrylcholinesterase (1)
- C. elegans (1)
- CA1 (1)
- CD-1 Mice (1)
- CD11 (1)
- CNS (1)
- COPD (1)
- Calcium signaling (1)
Articles 31 - 39 of 39
Full-Text Articles in Toxicology
Knockout Of Sphingosine Kinase 1 Attenuates Renal Interstitial Fibrosis In Unilateral Ureteral Obstruction (Uuo) Model, Xiwen Zhang
Theses and Dissertations
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite and an important signaling molecule that plays a significant role in fibrosis. S1P synthesis is catalyzed by sphingosine kinases (SphKs), which phosphorylate sphingosine into S1P. The present study tested the hypothesis that SphK1-S1P signaling pathway participates in the kidney damage in unilateral ureteral obstruction (UUO) model. Wild type and SphK1 knockout mice were subjected to UUO for 7 days or 14 days and then four groups of kidneys were collected: wild type control group (WT-C), wild type UUO group (WT-UUO), SphK1-/- control group (KO-C) and SphK1-/- UUO group (KO-UUO). The mRNA level of …
The Effects Of The Hiv-1 Tat Protein And Morphine On The Structure And Function Of The Hippocampal Ca1 Subfield, William D. Marks
The Effects Of The Hiv-1 Tat Protein And Morphine On The Structure And Function Of The Hippocampal Ca1 Subfield, William D. Marks
Theses and Dissertations
HIV is capable of causing a set of neurological diseases collectively termed the HIV Associated Neurocognitive Disorders (HAND). Worsening pathology is observed in HIV+ individuals who use opioid drugs. Memory problems are often observed in HAND, implicating HIV pathology in the hippocampus, and are also known to be exacerbated by morphine use. HIV-1 Tat was demonstrated to reduce spatial memory performance in multiple tasks, and individual subsets of CA1 interneurons were found to be selectively vulnerable to the effects of Tat, notably nNOS+/NPY- interneurons of the pyramidal layer and stratum radiatum, PV+ neurons of the pyramidal layer, and SST+ neurons …
Synthetic And Biological Exploration Of (+)-Boldine - Identification Of Potential Cns Receptor Ligands, Sujay Joseph
Synthetic And Biological Exploration Of (+)-Boldine - Identification Of Potential Cns Receptor Ligands, Sujay Joseph
Theses and Dissertations
(+)-Boldine, an aporphine alkaloid, is reported to be biologically active at various Central Nervous System(CNS) receptors. However, only a few Structure Activity Relationship(SAR) studies have been conducted using boldine’s aporphine scaffold. A library of novel analogs was synthesized from boldine to understand the effect of bisbenzylation at C2 and C9 positions on the affinity and selectivity at the serotonin receptors.
From Seed To Sky: Impacts Of Explosive Compounds On Vegetation Across Spatial And Developmental Scales, Stephen M. Via
From Seed To Sky: Impacts Of Explosive Compounds On Vegetation Across Spatial And Developmental Scales, Stephen M. Via
Theses and Dissertations
Explosive compounds are broadly distributed across the globe as a result of nearly two centuries of munitions use in warfare and military activities. Two explosive compounds have seen disproportionate use; RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) and TNT (2-methyl- 1,3,5-trinitrobenzene), being the most commonly found explosives in the environment. The effects of explosives on biota have been studied in great detail; however, there is a general lack of understanding with regard to broader ecological impacts of these contaminants. My dissertation objective was to follow the impacts of explosive compounds on vegetation across scales. Impacts on vegetation at the species scale alter community composition via …
Particulate Characterization And Control Evaluation For Carbon Fiber Composite Aircraft Crash Recovery Operations, Matthew R. Ferreri
Particulate Characterization And Control Evaluation For Carbon Fiber Composite Aircraft Crash Recovery Operations, Matthew R. Ferreri
Theses and Dissertations
Within the United States Air Force (USAF) Advanced Composite Material (ACM) is gaining an increasing use in military aircraft. With the number of aircraft that have increasingly large amounts of ACM materials, the probability of an incident with one of these aircraft also increases. When such an incident occurs the aircraft needs to be disassembled, removed, and later inspected as part of the accident investigation process. This disassembly process is termed “Crash Recovery Operations.” Carbon fibers have been shown to be hazardous to human health and a pilot study raised the suspicion that nanosized aerosol may be generated during the …
Low Dose Sarin Leads To Murine Cardiac Dysfunction, Michael W. Horenziak
Low Dose Sarin Leads To Murine Cardiac Dysfunction, Michael W. Horenziak
Theses and Dissertations
It has been reported that low dose sarin is associated with long-term pathology in the brain and heart; however, the effects of sarin on the heart have yet to be determined. In addition, sarin has been implicated as an etiological agent in Gulf War Illness. Thus, the role of sarin in producing illness has important military consequences. This study used echocardiography, electrocardiography, and histology to determine sarin’s effect on the murine cardiovascular system. C57BL/6J mice were injected with sarin at 0.4 LD50, 0.5 LD50, or saline on two consecutive days and studied for 10 weeks post exposure. The sarin animals …
In Vitro Toxicity Of Silver Nanoparticles In Human Lung Epithelial Cells, Christina R. Kearns
In Vitro Toxicity Of Silver Nanoparticles In Human Lung Epithelial Cells, Christina R. Kearns
Theses and Dissertations
Nanotechnology is quickly becoming incorporated into everyday products and uses. Silver nanoparticles, specifically, are being used in commercial products, to include aerosols. The purpose of this research was to determine whether silver nanoparticles are toxic to human lung epithelial cells. Different types (coated vs. uncoated), concentrations (10, 50, 100, and 200 µg/mL) and sizes (coated 5 and 80nm, uncoated 10 and 80nm) of silver nanoparticles were used during this study. Toxicity measurements were completed through in vitro techniques. Another study was also completed on toxicity mechanisms by measuring the reactive oxygen species (ROS) generated. Results showed that silver nanoparticles induce …
Effect Of Increased Carbon Dioxide Levels On Urushiol Production In Toxicodendron Radicans And Toxicodendron Toxicarium, Meredith Gilbert
Effect Of Increased Carbon Dioxide Levels On Urushiol Production In Toxicodendron Radicans And Toxicodendron Toxicarium, Meredith Gilbert
Theses and Dissertations
It is hypothesized that global warming is at least partially due to increased greenhouse gases, one of which is carbon dioxide. An increase in atmospheric carbon dioxide has been shown to stimulate higher rates of plant productivity, including the production of plant toxins like urushiol. Urushiol, a secondary plant compound produced in members of the Anacardiaceae family, causes dermatitis in sensitive individuals. An increase in urushiol production could increase the reactivity of certain individuals to plants like poison oak and poison ivy. To determine how elevated levels of atmospheric carbon dioxide would effect urushiol production, 16 samples of poison ivy …
Stochastic Intra-Cellular Modeling, Thomas E. Hopkins
Stochastic Intra-Cellular Modeling, Thomas E. Hopkins
Theses and Dissertations
Air Force personnel may sometimes come into contact with potentially harmful chemicals while performing their duties. Of course the Air Force desires to keep any potential health risks to its members to a minimum. To this end the Air Force would like to identify which chemicals are toxic, their level of toxicity, and the processes by which these chemicals disrupt normal biological activities at the cellular level. The development of mathematical models can be of great benefit to toxicity studies. Because real world systems involve randomness, that is noise, and the desire is to create mathematical models to represent those …