Toxicology Commons^™

Pharmaceuticals And Personal Care Products: Emerging Contaminants In Aquatic Ecosystems, Jenny E. Zenobio

Open Access Theses

In recent years, the presence of pharmaceuticals and personal care products (PPCPs) in aquatic systems has led to research on their fate and effects. PPCPs have been found in mixture in wastewater effluents, surface, ground, and drinking water at low concentrations from areas of intense urbanization. Although adverse effects to human health from the current environmental concentrations are unlikely, the impacts to ecological receptors are not clear. We performed field and laboratory studies to quantify and evaluate effects of PPCPs on fish. First, a field study was conducted at the Baca National Wildlife Refuge, Colorado (2010-2012) because a portion of …

Species - Dependent Cardiac And Motor Responses To Cholinergic Stimulation In Daphnia Pulex And Daphnia Magna, Bryan James Hannan

Wayne State University Theses

The role of acetylcholine (ACh) in regulating the activity of the heart and `feeding current' driven by the beating thoracic appendages of Daphnia pulex and Daphnia magna was evaluated using acetylcholinesterase inhibitors (AChE-I) and muscarinic receptor agonists. Single animals, tethered to a stainless steel pin, were tested in a watertight aquatic chamber that allowed free movement of appendages and swimming antennae. Heart contraction rate and the rate of thoracic appendage beating were quantified optically by measuring fluctuating changes in light-intensity caused by movement. Physostigmine, neostigmine, oxotremorine, pilocarpine as well as nicotine were used to study ACh and AChE. Atropine was …

Addressing Public Health Risks Of Persistent Pollutants Through Nutritional Modulation And Biomimetic Nanocomposite Remediation Platforms, Bradley J. Newsome

Theses and Dissertations--Chemistry

Due to their relative chemical stability and ubiquity in the environment, chlorinated organic contaminants such as polychlorinated biphenyls (PCBs) pose significant health risks and enduring remediation challenges. Engineered nanoparticles (NPs) provide a novel platform for sensing/remediation of these toxicants, in addition to the growing use of NPs in many industrial and biomedical applications, but there remains concern for their potential long-term health effects. Research highlighted herein also represents a transdisciplinary approach to address human health challenges associated with exposure to PCBs and NPs. The objectives of this dissertation research are two-fold, 1) to develop effective methods for capture/sensing and remediation …

Impact Of Zinc Oxide Nanoparticles On Green Pea Plant & Seed Quality And Effects On Physiological Traits Of Green Peas, Corn, And Zucchini By Silver Nanoparticles, Arnab Mukherjee

Open Access Theses & Dissertations

The production and use of numerous engineered nanomaterials (ENMs) have increased exponentially over the past decade. Nanoparticles (NPs), ENMs possessing diameter between 1-100 nm, (NPs), are widely used in many applications. Worldwide consumption of NPs has increased their possible release into the environment. This, in turn, has elevated the extent of the potential impacts of NP exposure to living and non-living organisms. This is why the assessment of the impact of NPs on different environmental components, especially on plants, the producer in the food web, has become a very important aspect of nano-ecotoxicology. However, studies focusing on phytotoxicity and effects …

Effects Of Salinity And Dissolved Organic Matter On Cu Toxicity To Americamysis Bahia In Estuarine Environments, Rabia Nasir

Theses and Dissertations (Comprehensive)

As salinity increases the geochemical speciation of Cu is altered as a result of organic/inorganic complexation/competition. Such salinity changes may further challenge the osmoregulatory capabilities of euryhaline organisms. This chemical-biological interaction complicates the understanding of the impacts of Cu in estuarine waters. Dissolved organic matter (DOM) has been widely established to be an important modifier of Cu toxicity in freshwaters however its effectiveness in modulating Cu toxicity across the range of salinities that occur in estuarine conditions has not been studied in a systematic manner. Site to site differences in DOM quality with respect to the potential for toxicity mitigation …

Atrazine And Nitrate In Public Drinking Water Supplies And Non-Hodgkin Lymphoma In Nebraska, Usa, Martha G. Rhoades, Jane L. Meza, Cheryl L. Beseler, Patrick J. Shea, Andy Kahle, Julie M. Vose, Kent M. Eskridge, Roy F. Spalding

School of Natural Resources: Faculty Publications

A secondary analysis of 1999–2002 Nebraska case-control data was conducted to assess the risk of non-Hodgkin lymphoma (NHL) associated with exposure to nitrate- and atrazine-contaminated drinking water. Water chemistry data were collected and weighted by well contribution and proximity of residence to water supply, followed by logistic regression to determine odds ratios (OR) and 95% confidence intervals (CI). We found no association between NHL risk and exposure to drinking water containing atrazine or nitrate alone. Risk associated with the interaction of nitrate and atrazine in drinking water was elevated (OR, 2.5; CI, 1.0–6.2). Risk of indolent B-cell lymphoma was higher …

Arsenic Contamination In Groundwater In Vietnam: An Overview And Analysis Of The Historical, Cultural, Economic, And Political Parameters In The Success Of Various Mitigation Options, Thuy M. Ly

Pomona Senior Theses

Although arsenic is naturally present in the environment, 99% of human exposure to arsenic is through ingestion. Throughout history, arsenic is known as “the king of poisons”; it is mutagenic, carcinogenic, and teratogenic. Even in smaller concentrations, it accumulates in the body and takes decades before any physical symptoms of arsenic poisoning shows. According to the World Health Organization (WHO), the safe concentration of arsenic in drinking water is 10 µg/L. However, this limit is often times ignored until it is decades too late and people begin showing symptoms of having been poisoned.

This is the current situation for Vietnam, …

A Survey Of Selected Pharmaceuticals And Personal Care Products In A Binational River And Their Effects On A Member Of Its Zooplankton Community, Plationus Patulus (Rotifera), Diana Angelica Martinez Gomez

Open Access Theses & Dissertations

The presence of 9 selected PPCPs (acetaminophen, caffeine, cotinine, codeine, fluoxetine, erythromycin, ciprofloxacin, sulfamethazine, and trimethoprim) was surveyed in water samples collected at four sites along the middle Rio Grande during two flow regimes (irrigation and non-irrigation). Water collection for PPCPs analyses were conducted from August 2010 through September 2011. Three of the sites were located upstream, in, and downstream of the El Paso, TX/Ciudad Juárez, MX metroplex. Site selection was based on their proximity to the metroplex and due to the fact that the Rio Grande in this region is an effluent receiver water system (IBWC, 2011). The fourth …

Evaluating And Regulating Lead In Artificial Turf, Gregory Van Ulirsch, Kevin Gleason, Shawn Gerstenberger, Deaphne B. Moffett, Glenn Pulliam, Tariq Ahmed, Jerald Fagliano

Environmental & Global Health Faculty Research

Background: In 2007, a synthetic turf recreational field in Newark, New Jersey, was closed because lead was found in synthetic turf fibers and in surface dust at concentrations exceeding hazard criteria. Consequently, public health professionals across the country began testing synthetic turf to determine whether it represented a lead hazard. Currently, no standardized methods exist to test for lead in synthetic turf or to assess lead hazards.

Objectives: Our objectives were to increase awareness of potential lead exposure from synthetic turf by presenting data showing elevated lead in fibers and turf-derived dust; identify risk assessment uncertainties; recommend that federal and/or …

Development And Recycling Of Novel Arsenic Removal Technology, Morgan Jones

Mahurin Honors College Capstone Experience/Thesis Projects

As of 2006, the U.S. Environmental Protection Agency (EPA) changed the Maximum Contaminant Level (MCL) for arsenic from 50 parts per billion (ppb), to 10ppb because of links to cancer. Current remediation technologies are expensive; therefore, this change will result in increased economic pressure on rural communities with high levels of arsenic in their drinking water. Lowering of the standard has spurred the development of a novel remediation technology that has shown the ability to reduce arsenic in drinking water at the source, with the added benefit of low-cost disposal of a stable and benign waste product in ordinary landfills. …

Landholder Information For The Safe Use And Management Of Strychnine For Emu Control, Renee Donovan, David Goodall

Biosecurity published reports

Farmnote 34/2003 - Guide to safe use of strychnine poison for emu control included.

Strychnine is a highly poisonous substance that is used in Western Australia for the control of Wild Dogs and Emus. Its use is restricted by law.

This manual outlines your roles and responsibilities in regard to Strychnine use for emu control. In particular this manual outlines the essential information you need to know in regard to:

• The legislative requirements for Strychnine control in Western Australia
• The properties and mode of action of Strychnine
• How to apply to have a strychnine emu baiting program carried out on …

Landholder Information For The Safe Use And Management Of Strychnine For Wild Dog Traps, Renee Donovan, David Goodall

Biosecurity published reports

Farmnote 33/2003 - Guide to the safe use of strychnine for jawed traps is included.

Strychnine is a highly poisonous substance that is used in Western Australia for the control of Wild Dogs and Emus. Its use is restricted by law.

This manual outlines your roles and responsibilities for using and managing Strychnine for Wild Dog control. In particular, this manual outlines the essential information you need to know in regard to:

• The legislative requirements for Strychnine control in Western Australia
• The properties and mode of action of Strychnine « How to lodge an application to use Strychnine
• How to …

Landholder Information For The Safe Use And Management Of 1080, Renee Donovan, David Goodall

Biosecurity published reports

This manual outlines your roles and responsibilities for using and managing 1080. In particular this manual outlines the essential information you need to know in regard to:

• The legislative requirements for 1080 control in Western Australia
• The properties and mode of action of 1080
• How to lodge an application to lay 1080 baits How to safely store and transport 1080
• The procedures and notification required to carry out a baiting proposal
• Personal safety, identifying signs of poisoning & effecting appropriate first aid treatment
• Your responsibilities for notifying DAFWA and the Police of any accidents or incidents
• Methods for evaluating the …

Environmental Factors In Autoimmunity: Assessment Of Immunotoxicity Of Phthalates In The Induction Of Lupus-Type Anti-Dna Antibodies, So-Yon Lim

All-Inclusive List of Electronic Theses and Dissertations

Objectives: Little is known of the role of specific environmental factors in promoting autoimmune disorders such as systemic lupus erythematosus (SLE). The broad objective of this study was to address how exposure to phthalates, common environmental factors m foods, and biomedical devices could affect the immune functions of resistant and autoimmune-prone mice. Methods: The environmental chemical model used in this study is phthalates, which are widely used in various forms and readily occur during day-to-day human contacts. Groups of nonautoimmune-prone (BALB/c, DBA/2 and C57BL/6) and susceptible (NZB, NZB/W Fl) mice were immunized with phthalates ( ortho, meta and para) conjugated …

Recognizing Toxic Species In Aquatic Habitats: A Potential Concern In Lake Management, Mikolaj Kokocinski, Harold G. Marshall

Biological Sciences Faculty Publications

The importance of distinguishing toxic and non-toxic algal species is becoming a more common problem for management decisions associated with various freshwater and estuarine habitats. An example is given where two dinoflagellates, originally unidentified as closely resembling the toxin producing Pfiesteria spp., have been compared to these species. In order to clarify any relationship to Pfiesteria spp., scanning electron microscopy was used to determine the plate tabulation patterns of these dinoflagellates and make comparisons to the tabulation present in Pfiesteria spp. The results indicated significant differences in the plate tabulations of these taxa to distinguish them from Pfiesteria …

Optimization Of Edxrf For The Study Of Heavy Metal Pollution Of Lake Victoria, Nk Mahommed, In Makundi

Tanzania Journal of Science

This study reports on the optimisation and calibration of the Energy Dispersive X-ray Fluorescence (EDXRF) spectrometer installed in the Department of Physics, University of Dar es Salaam. The spectrometer was subsequently utilized to determine concentrations of heavy metals in water hyacinth (Eichhornia crassipes (Mart) Solms.) found growing along the shore of Lake Victoria. The optimal conditions and detection limits were determined experimentally by variation of the excitation parameters. The study found that the use of a collimator with two apertures of diameter 4 mm each placed 8 mm apart and made of materials that do not interfere with elements to …

1080 Summary Information, Department Of Agriculture, Western Australia, Department Of Conservation And Land Management, Western Australia, Department Of Health, Western Australia

Biosecurity research reports

Fluoroacetate, the active ingredient of 1080, occurs naturally in toxic plants in Australia, South Africa, and South America. Manufactured I080 underpins most vertebrate pest control programs in Australia and New Zealand. Fluoroacetate occurs naturally in about 40 plant species in Australia with most of these plants restricted to the south-west of WA.

I080 was introduced to rabbit control programs in the early 1950s and therefore has a long history of proven effectiveness and safety in Australia. There have been few repo1ted problems associated with human safety, environmental persistence, bioaccumulation or impact on populations of non-target species.

In particular, I080 baits …

Assessment Of Heavy Metal Pollution In The Lupa Gold Field, Sw Tanzania, S. R. Mnali

Tanzania Journal of Science

The concentrations of AS, Cd, Cr, Cu, Hg and Pb were determined in water, stream sediments, soil, and mine tailings from Lupa Gold Field (LGF), SW Tanzania, in order to assess their pollution levels. As, Cd and Cr were determined by automated Graphite Furnace Absorption Spectrophotometry. Cu and Pb were analysed by Air-Acetylene Flame, while Hg was analysed by Cold Vapour Atomic Absorption Spectrophotometry. The mean concentrations obtained were: As: 0.44 ppb (water), 1.2 ppm (sediments), 0.44 ppm (soil) and 5.2 ppm (tailings); Cd: 0.03 ppb (water), 0.03 ppm (sediments), 0.03 ppm (soil) and 0.50 ppm (tailings); Cr: 1.4 ppb …

The Standardized Fish Bioassay Procedure For Detecting And Culturing Actively Toxic Pfiesteria, Used By Two Reference Laboratories For Atlantic And Gulf Coast States, Joann M. Burkholder, Harold G. Marshall, David W. Seaborn, Nora J. Deamer-Melia

Biological Sciences Faculty Publications

In the absence of purified standards of toxins from Pfiesteria species, appropriately conducted fish bioassays are the "gold standard" that must be used to detect toxic strains of Pfiesteria slop. from natural estuarine water or sediment samples and to culture actively toxic Pfiesteria. In this article, we describe the standardized steps of our fish bioassay as an abbreviated term for a procedure that includes two sets of trials with fish, following the Henle-Koch postulates modified for toxic rather than infectious agents. This procedure was developed in 1991, and has been refined over more than 12 years of experience in …

Evaluation Of Toxicity, Bioavailability And Speciation Of Lead, Zinc And Cadmium In Mine/Mill Wastewaters, Mujde Erten-Unal, Bobby G. Wixson, Nord Gale, Jerry L. Pitt

Civil & Environmental Engineering Faculty Publications

The toxicity of common compounds of lead, cadmium and zinc was evaluated in waters similar to that found in the world's largest lead producing area in Missouri. Static, acute toxicity tests were performed using fathead minnows (Pimephales promelas) and water fleas (Daphnia magna) respectively. Test organisms were subjected to varying amounts of sulfide, carbonate, chloride and sulfate salts of lead, zinc and cadmium mixed in hard, alkaline waters typical to this region. Median lethal concentrations were calculated using nominal versus measured metal concentrations. Measured metal concentrations included four different metal fractionation (extraction/filtration) techniques at different pH …

1080 Operational Procedures Manual - Second Edition, Agriculture Western Australia

Biosecurity published reports

Sodium fluoroacetate (1080) is an extremely toxic substance which can be a danger to humans if handled incorrectly. At the same time 1080 is the most effective and efficient poison for the control of Western Australia's main vertebrate pest species including rabbits, wild dogs and foxes. One of the main reasons for its usefulness in Western Australia is that many native animals have a high tolerance to it and so may not be affected by baiting.

Industry Resource Protection Program (IRPP) This program, part of Agriculture Western Australia, supports feral animal control carried out by its staff and community groups. …

Ecological Water Treatment System For Removal Of Phosphorus And Nitrogen From Polluted Water, Ray W. Drenner, Donald J. Day, Stacy J. Basham, J. Durward Smith, Susan I. Jensen

School of Natural Resources: Faculty Publications

We propose that phosphorus and nitrogen can be removed from polluted water using an ecological water treatment system consisting of periphyton and fish. In the proposed system, polluted water flows through a series of vessels, and the nutrients are taken up by periphyton growing on porous screens. Algal-grazing fish feed on the periphyton and either assimilate or egest the nutrients in mucus-bound feces that settle from the water into a sediment trap. Both the fish and their feces can be harvested as nutrient sinks. In this study we examined the effects of an algal-grazing cichlid (Tilapia mossambica) and …

Fish Tissue Contamination In Maine Lakes : Data Report, Jeanne Difranco, Linda Bacon, Barry Mower, David Courtemanch

Maine Collection

Fish Tissue Contamination in Maine Lakes : Data Report

by Jeanne DiFranco, Linda Bacon, Barry Mower and David Courtemanch

Regional Environmental Monitoring and Assessment Program (REMAP)

State of Maine Department of Environmental Protection, Bureau of Land and Water Quality, Division of Environmental Assessment, State House Station 17, Augusta, Maine 04333 (September 1995).

Contents: List of Figures and Tables / I. Introduction / II. Goals and Objectives / III. Experimental Design / IV. Methods / V. Data / VI. Quality Assurance-Quality Control / Appendices A-H

Pesticide Use On Broccoli, Cabbage, Cauliflower And Peppers Grown In Connecticut: 1991, James J. Turner Ii, Candace L. Bartholomew

Storrs Agricultural Experiment Station

No abstract provided.

Pesticide Use On Peaches And Pears Grown In Connecticut: 1991, James L. Turner Ii, Candace L. Bartholomew

Storrs Agricultural Experiment Station

No abstract provided.

Pesticide Use On Apples Grown In Connecticut: 1990, James L. Turner Ii, Candace L. Bartholomew

Storrs Agricultural Experiment Station

No abstract provided.

Development And Standardization Of A Short-Term Assay For Evaluating Polluted Estuarine And Coastal Environments: The Medaka Embryo-Larval Assay, Michael Frederick Helmstetter

OES Theses and Dissertations

The eggs of the Japanese medaka (Oryzias latipes) were employed in a number of studies to develop a routine, standardized assay which can assess the acute and sublethal impacts of individual toxicants and complex mixtures. The eggs of this Cyprinodont minnow were topically treated with each toxicant or mixture dissolved in membrane permeable dimethylsulfoxide (DMSO) solvent. Nine chemicals were initially evaluated with two, pentachlorophenol (PCP) and tributyltin chloride (TBTCl), subsequently selected for extensive evaluations of salinity tolerance and the accuracy of the topical exposure method for representing a typical immersion exposure. The amount of material actually penetrating the eggs was …

Bulletin No 4219 - Chemical Control Of Insect Pests In Field Crops And Pastures, T. P. Quinn, G. P. Mangano, P. J. Michael

Bulletins 4000 -

Chemicals currently registered in Western Australia for use against pests of field crops and pasture are given in the following tables. Trade names are listed alongside each chemical formulation.

Department of Agriculture Bulletin 4185 "Insect and allied pests of extensive farming" will help you identify the pest(s) through coloured photographs, descriptions and keys. Information on the type of damage, life cycle and control is also provided. Further information is available in Farmnotes on specific pests and on pests of a particular crop.

The Poison Schedule for each product is indicated in the table. Extremely toxic chemicals are labelled as "dangerous …

Gas Chromatographic Method For Determination Of 28 Volatile Organic Compounds Emitted From A Sewerage Plant, Yeming Sun

Theses

In this study, 28 volatile organic compounds (VOCs) emitted from the Linden Roselle Sewerage Authority Plant (LRSA) were monitered. The determination by gas chromatography (GC) is presented. This work emphasizes the collection of whole air samples, using a canister-based sampling system with cryogenic concentration. An appropriate temperature program was selected to obtain the best sample separation. The procedure for the identification of 28 standard gas mixture was achieved by comparing the chromatograms of sample with those of the specific groups of target compounds, as well as by comparing the sample with the results from GC Mass spectrometeric analysis. Because of …

Stabilization/Solidification Of Organic Containing Wastes Using Organophilic Clay And Coal Fly Ash, Edith Lagoutte

Theses

The relative merits of eight different coal fly ashes for use in the stabilization/Solidification of a waste containing both heavy metals and pentachlorophenol were investigated. Also studied, was the possible use of either untreated or treated (with hexade-cyl ammonium bromide) clay to enhance the stabilization of the organic. The sample composition was : 62% foundry baghouse dust (or 60% if 2% clay as added to the sample), 4.5% cement, 14% coal fly ash, 19.5% water. Pentachlorophenol was chosen as represen¬tative of the organic contamination. All tests were performed after curing the samples at 22°C, 98% Rh for 28 days. The …