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Articles 1051 - 1080 of 1180

Full-Text Articles in Pharmacology

Polysaccharide-Containing Fraction From Artemisia Argyi Inhibits Tumor Cell-Induced Platelet Aggregation By Blocking Interaction Of Podoplanin With C-Type Lectin-Like Receptor 2, Ching-Ping Tseng, Yu-Ling Huang, Yao-Wen Chang, Hsiang-Ruei Liao, Yu-Li Chen, Pei-Wen Hsieh Jun 2020

Polysaccharide-Containing Fraction From Artemisia Argyi Inhibits Tumor Cell-Induced Platelet Aggregation By Blocking Interaction Of Podoplanin With C-Type Lectin-Like Receptor 2, Ching-Ping Tseng, Yu-Ling Huang, Yao-Wen Chang, Hsiang-Ruei Liao, Yu-Li Chen, Pei-Wen Hsieh

Journal of Food and Drug Analysis

Hepatocellular carcinoma (HCC) is one of the most common malignancies in Taiwan. Many risks factors induce liver chronic inflammation, fibrosis, cirrhosis, and hepatocellular carcinoma. Mulberry fruits containing polyphenols to remove free radicals and mitigate inflammation has been reported to not only against gastric cancer, melanoma and leukemia but also prevent liver injury induced by alcohol or CCl4 in previous researches. The aim of this study is to examine whether Mulberry could inhibit hepatocarcinogenesis. In animal experiment, diethylnitrosamine (DEN) was used to induce hepatic tumorgenesis. After injecting DEN, the rats treated with mulberry water extracts (MWE) had less and smaller tumor …

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Alleviating Chronic Kidney Disease Progression Through Modulating The Critical Genus Of Gut Microbiota In A Cisplatin-Induced Lanyu Pig Model, Ya-Jane Lee, Kuan-Yi Li, Pin-Jhu Wang, Hsiao-Wen Huang, Ming-Ju Chen Jun 2020

Alleviating Chronic Kidney Disease Progression Through Modulating The Critical Genus Of Gut Microbiota In A Cisplatin-Induced Lanyu Pig Model, Ya-Jane Lee, Kuan-Yi Li, Pin-Jhu Wang, Hsiao-Wen Huang, Ming-Ju Chen

Journal of Food and Drug Analysis

Antcins are unique phytosterols isolated from A. cinnamomea and A. salmomea, which are the endemic fungus of Taiwan. A. cinnamomea has long been highly valued medicinal mushroom in Taiwan and traditionally used as a folk remedy for various human illness. Recent scientific explorations claimed that the pharmacological activities of A. cinnamomea and A. salmomonea are gone beyond their original usage. The therapeutic efficacy of these medicinal mushrooms was attributed to their high content of unique bioactive secondary metabolites, including terpenoids, benzenoids, ubiquinol derivatives, polysaccharides, lignans, nucleic acids, steroids, and maleic/succinic acid derivatives. Antcins is a group of steroids in Antrodia …

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Bioactive Peptides Attenuate Cardiac Hypertrophy And Fibrosis In Spontaneously Hypertensive Rat Hearts, Chih Yang Huang, Srinivasan Nithiyanantham, Jia Ying Liao, Wan Teng Lin Jun 2020

Bioactive Peptides Attenuate Cardiac Hypertrophy And Fibrosis In Spontaneously Hypertensive Rat Hearts, Chih Yang Huang, Srinivasan Nithiyanantham, Jia Ying Liao, Wan Teng Lin

Journal of Food and Drug Analysis

The incidence of neurodegeneration leading to the conditions such as Alzheimer's and Parkinson's diseases are on the increase, they require the approaches that focus on protection prevention rather than treatment. Plants are rich sources of many compounds which possess medicinal properties. We sought to investigate the neuroprotective effects of Uncaria hirsuta and its compounds on D-galactose-induced stress in BALB/c mice as well as 6-hydroxydopamine (6-OHDA)-induced stress in mouse nerve growth factor (mNGF)-differentiated PC12 cells. Our results demonstrate that the 95% ethanol extract of U. hirsuta reversed the D-galactose-induced learning and memory dysfunctions and decreased the malodialdehyde levels. Furthermore, the isolated …

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Mulberry Fruits Extracts Induce Apoptosis And Autophagy Of Liver Cancer Cell And Prevent Hepatocarcinogenesis In Vivo, Kwok-Chui Cheng, Chau-Jong Wang, Yun-Ching Chang, Tung-Wei Hung, Chun-Jung Lai, Chi-Wen Kuo, Hui-Pei Huang Jun 2020

Mulberry Fruits Extracts Induce Apoptosis And Autophagy Of Liver Cancer Cell And Prevent Hepatocarcinogenesis In Vivo, Kwok-Chui Cheng, Chau-Jong Wang, Yun-Ching Chang, Tung-Wei Hung, Chun-Jung Lai, Chi-Wen Kuo, Hui-Pei Huang

Journal of Food and Drug Analysis

No abstract provided.

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Biotransformation Of Mogrosides From Siraitia Grosvenorii By Ganoderma Lucidum Mycelium And The Purification Of Mogroside Iii E By Macroporous Resins, Chun-Hui Chiu, Reuben Wang, Shasha Zhuang, Pei-Yin Lin, Yi-Chen Lo, Ting-Jang Lu Jun 2020

Biotransformation Of Mogrosides From Siraitia Grosvenorii By Ganoderma Lucidum Mycelium And The Purification Of Mogroside Iii E By Macroporous Resins, Chun-Hui Chiu, Reuben Wang, Shasha Zhuang, Pei-Yin Lin, Yi-Chen Lo, Ting-Jang Lu

Journal of Food and Drug Analysis

No abstract provided.

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Gas Chromatography-Mass Spectrometry-Based Analytical Strategies For Fatty Acid Analysis In Biological Samples, H.-H. Chiu, C.-H. Kuo Jun 2020

Gas Chromatography-Mass Spectrometry-Based Analytical Strategies For Fatty Acid Analysis In Biological Samples, H.-H. Chiu, C.-H. Kuo

Journal of Food and Drug Analysis

Over the past few decades, phytochemicals widely present in edible plants have exhibited compelling positive biological impact on human health, including treating some cancers. In some cases, metabolites and artificially modified products of these natural compounds have shown better chemopreventive effects than their natural counterparts. Along with direct chemopreventive strategies using phytochemicals to treat cancer by leading to cell cycle arrest, autophagy and apoptosis, natural compounds have been shown to reverse adverse epigenetic regulation, including altering DNA methylation and histone modification, modulating miRNA expression, promoting expression of phase II enzyme for detoxification, balancing inflammation responses, recovering circadian rhythm from misalignment, …

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A Mechanistic And Empirical Review Of Antcins, A New Class Of Phytosterols Of Formosan Fungi Origin, Kumar K.J. Senthil, Vani M. Gokila, Chieh-Yin Chen, Wen-Wei Hsiao, Jing Li, Zhan-Xi Lin, Fang-Hua Chu, Gow-Chin Yen, Sheng-Yang Wang Jun 2020

A Mechanistic And Empirical Review Of Antcins, A New Class Of Phytosterols Of Formosan Fungi Origin, Kumar K.J. Senthil, Vani M. Gokila, Chieh-Yin Chen, Wen-Wei Hsiao, Jing Li, Zhan-Xi Lin, Fang-Hua Chu, Gow-Chin Yen, Sheng-Yang Wang

Journal of Food and Drug Analysis

Tumor cell-induced platelet aggregation (TCIPA) is a mechanism that involves the protection of tumor cells in the circulation and the promotion of tumor cell invasion and metastases. The C-type lectin-like receptor 2 (CLEC-2) that binds podoplanin (PDPN) is on the platelet surface and facilitates the TCIPA. Selective blockage of the PDPN-mediated platelet-tumor cell interaction is thereby a plausible strategy for inhibiting metastases. In a search for antagonists of PDPN- and tumor cell-induced platelet aggregation, traditional Chinese medicines were screened and it was found that the water extract of Artemisia argyi leaves selectively inhibited the PDPN-induced platelet aggregation. Bioactivity-guided fractionation analysis …

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Recent Advances In Cancer Chemoprevention With Phytochemicals, Yen-Chun Koh, Chi-Tang Ho, Min-Hsiung Pan Jun 2020

Recent Advances In Cancer Chemoprevention With Phytochemicals, Yen-Chun Koh, Chi-Tang Ho, Min-Hsiung Pan

Journal of Food and Drug Analysis

In the present study, we investigated the effects of Probiotic mix 1 (Pm1) with Lactobacillus plantarum subsp. plantarum, Lactobacillus paracasei subsp. paracasei, and Streptococcus salivarius subsp. thermophilus on preventing renal injury using a chronic kidney disease (CKD) minipig model previously developed in our lab using cisplatin-induced CKD in Lanyu pigs. The results indicated that the high dosage Pm1 (H.Pm1) group demonstrated lower incidence of lesions, including atrophy, mononuclear inflammation, cell infiltration, and interstitial fibrosis in renal tubules in hematoxylin and eosin (H&E) and Masson's trichrome stain. We further systematically investigated the preventing effect of Pm1. The H.Pm1 group decreased inflammatory …

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Evaluation Of Analysis Of Cholesterol Oxidation Products And Heterocyclic Amines In Duck And Their Formation As Affected By Roasting Methods, Kai-Yu Hsu, Baskaran Stephen Inbaraj, Bing-Huei Chen Jun 2020

Evaluation Of Analysis Of Cholesterol Oxidation Products And Heterocyclic Amines In Duck And Their Formation As Affected By Roasting Methods, Kai-Yu Hsu, Baskaran Stephen Inbaraj, Bing-Huei Chen

Journal of Food and Drug Analysis

Roast duck, a popular meat commodity in Asian countries especially Taiwan and China, can produce many types of toxic compounds such as cholesterol oxidation products (COPs) and heterocyclic amines (HAs). The objectives of this study were to evaluate analysis of COPs and HAs in duck by GCeMS and UPLC-MS/MS respectively, and study their formation as affected by roasting methods including traditional oven, fan oven and superheated steam oven. Results showed that both high precision and accuracy was attained by using the QuEChERS method with reduced separation time of 14 min for 7 COPs and 4.5 min for 21 HAs by …

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Preparation, Evaluation And Metabolites Study In Rats Of Novel Isoginkgetin-Loaded Tpgs/Soluplus Mixed Nanomicelles, Xue Feng, Yu-Ting Chen, Lu-Ya Li, Yu-Peng Sun, Hai-Rong Wang, Lan-Tong Zhang Jun 2020

Preparation, Evaluation And Metabolites Study In Rats Of Novel Isoginkgetin-Loaded Tpgs/Soluplus Mixed Nanomicelles, Xue Feng, Yu-Ting Chen, Lu-Ya Li, Yu-Peng Sun, Hai-Rong Wang, Lan-Tong Zhang

Journal of Food and Drug Analysis

At present, cancer is one of the most lethal diseases in the world, and researchers are committed to developing effective anticancer drugs. Isoginkgetin (IGG) is a kind of biflavone with the potential to treat cancer due to the features of altering the cell cycle and inhibiting tumor cell infiltration. However, its solubility, absorbability and bioavailability are poor, so in this study, IGG was prepared into mixed nanomicelles and evaluated in vitro and in vivo. After condition optimization, IGG-loaded TPGS/soluplus mixed nanomicelles with particle size of 62.34 ± 1.10 nm, entrapment efficiency of 96.92 ± 0.66% and drug loading of 2.42 …

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Rapid Identification Of Nicotine In Electronic Cigarette Liquids Based On Surface-Enhanced Raman Scattering, Jun-Yi Chien, Yong-Chun Gu, Hsin-Mei Tsai, Chun-Hao Liu, Chia-Yuan Yen, Yuh-Lin Wang, Juen-Kai Wang, Chi-Hung Lin Jun 2020

Rapid Identification Of Nicotine In Electronic Cigarette Liquids Based On Surface-Enhanced Raman Scattering, Jun-Yi Chien, Yong-Chun Gu, Hsin-Mei Tsai, Chun-Hao Liu, Chia-Yuan Yen, Yuh-Lin Wang, Juen-Kai Wang, Chi-Hung Lin

Journal of Food and Drug Analysis

Nicotine-containing electronic cigarette liquid (e-liquid) is prohibited in many countries, creating requirements for rapid detection approaches for on-site inspection or screening for large amounts of samples. Here, we demonstrate a simple way to identify nicotine using surface-enhanced Raman scattering (SERS) with substrates made of silver nanoparticle arrays imbedded in anodic aluminum oxide nanochannels (Ag/AAO). Compared with the reported colloidal nanoparticle-based SERS, that required serial dilutions to enable colloid aggregation in the viscous e-liquid, a small amount of undiluted e-liquid sample can be directly added onto our solid-phase Ag/AAO substrate without any pre-treatment. The sensitivity of our SERS measurements is 2e3 …

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A Multi-Analyte Lc-Ms/Ms Method For Screening And Quantification Of Nitrosamines In Sartans, Shu-Han Chang, Ching-Chia Chang, Li-Jing Wang, Wei-Ching Chen, Shu-Yu Fan, Chi-Zong Zang, Ya-Hui Hsu, Mei-Chih Lin, Su-Hsiang Tseng, Der-Yuan Wang Jun 2020

A Multi-Analyte Lc-Ms/Ms Method For Screening And Quantification Of Nitrosamines In Sartans, Shu-Han Chang, Ching-Chia Chang, Li-Jing Wang, Wei-Ching Chen, Shu-Yu Fan, Chi-Zong Zang, Ya-Hui Hsu, Mei-Chih Lin, Su-Hsiang Tseng, Der-Yuan Wang

Journal of Food and Drug Analysis

An incident of sartan medicine contamination was notified by Europe in June 2018. The contaminant was identified as a probable carcinogenic nitrosamine and the recalls of sartan medicines were soon made. Since then, more nitrosamine contaminants in sartan medicines were reported. To broaden the applicability and variety in nitrosamine determination, a multi-analyte method is required. In this study, a feasible and sensitive multi-analyte LC-MS/MS method for determination of 12 nitrosamines in sartans was established, where the active pharmaceutical ingredients and final products merchandised in Taiwan were also examined. Chromatographic separation was achieved on an Xselect® HSS T3 column (15 cm …

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Anti-Inflammatory Effects Of Peptides From A Marine Algicolous Fungus Acremonium Sp. Ntu492 In Bv-2 Microglial Cells, George Hsiao, Shih-Wei Wang, Yin-Ru Chiang, Wei-Chiung Chi, Yueh-Hsiung Kuo, Do Anh Phong, Chia-Yu Chen, Tzong-Huei Lee Jun 2020

Anti-Inflammatory Effects Of Peptides From A Marine Algicolous Fungus Acremonium Sp. Ntu492 In Bv-2 Microglial Cells, George Hsiao, Shih-Wei Wang, Yin-Ru Chiang, Wei-Chiung Chi, Yueh-Hsiung Kuo, Do Anh Phong, Chia-Yu Chen, Tzong-Huei Lee

Journal of Food and Drug Analysis

Located in tropical and subtropical region, Taiwan is an island with high algal species diversity. In this study, a number of fungal strains were isolated from marine macroalgae collected from northeastern intertidal zone of Taiwan. Preliminary anti-inflammatory screening has shown that the methanolic extracts of solid fermented products of the red alga Mastophora rosea-derived fungal strain Acremonium sp. NTU492 exhibited significant bioactivity. In an attempt to disclose the active principles from this fungal strain, a series of separation and purification was thus undertaken, which has led to the isolation and characterization of seven compounds including four new peptides, namely acrepeptins …

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A Rapid Strategy For Screening High-Efficiency Pcsk9 Inhibitors From Ginkgo Biloba Leaves By Ligand Fishing, Hplc-Q-Tof-Ms And Interdisciplinary Assay, Li Li, Meng-Lin Fan, Ya-Nan Li, Ya-Xuan Huang, Xiu-Feng Liu, Ji-Hua Liu Jun 2020

A Rapid Strategy For Screening High-Efficiency Pcsk9 Inhibitors From Ginkgo Biloba Leaves By Ligand Fishing, Hplc-Q-Tof-Ms And Interdisciplinary Assay, Li Li, Meng-Lin Fan, Ya-Nan Li, Ya-Xuan Huang, Xiu-Feng Liu, Ji-Hua Liu

Journal of Food and Drug Analysis

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an attractive target for new cholesterol-lowering drug development. Here, we developed a method integrating ligand fishing, HPLC-Q-TOF-MS and interdisciplinary assay, aiming to explore potential PCSK9 inhibitors from mixtures rapidly and accurately. PCSK9 was expressed and purified firstly, and then the recombined PCSK9 was coated on the surface of magnetic beads (MBs). The PCSK9-immobilized MBs (PCSK9-MBs) were used for ligand fishing combined with HPLC and Q-TOF-MS/MS. Ginkgo biloba leaves (GBL), an herbal medicine widely used in Asia and Europe with good efficacy in treatment of hypercholesterolemia, were chosen as an illustration for ligand fishing. …

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Analysis Of Flavor And Other Metabolites In Lemon Juice (Citrus Limon) From Huanglongbing-Affected Trees Grafted On Different Rootstocks, Laura Reuss, Shi Feng, Wei-Lun Hung, Qibin Yu, Frederick G. Gmitter Jr, Yu Wang Jun 2020

Analysis Of Flavor And Other Metabolites In Lemon Juice (Citrus Limon) From Huanglongbing-Affected Trees Grafted On Different Rootstocks, Laura Reuss, Shi Feng, Wei-Lun Hung, Qibin Yu, Frederick G. Gmitter Jr, Yu Wang

Journal of Food and Drug Analysis

Flavor perception integrates sensory input from chemical receptors triggered by taste- and aroma-active metabolites to contribute to food flavor quality. Many factors alter flavor quality. Disease affects aroma and flavonoid constituents, causing off-flavors in plants. Huanglongbing (HLB) disease negatively affects citrus, although lemons are more tolerant. Lemon juice quality of HLB-affected fruits is not well studied. Lemon juice aroma-active compounds were profiled in this study using gas chromatography/mass spectrometry-olfactometry, and other metabolites contributing to overall flavor quality were investigated. Lemon juice from different rootstocks was discriminated using the metabolic profile. Flavor and other lemon juice metabolites also distinguished symptomatic from …

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Chemometric Authentication Of Pu'er Teas In Terms Of Multielement Stable Isotope Ratios Analysis By Ea-Irms And Icp-Ms, Honglin Liu, Yitao Zeng, Xin Zhao, Huarong Tong Jun 2020

Chemometric Authentication Of Pu'er Teas In Terms Of Multielement Stable Isotope Ratios Analysis By Ea-Irms And Icp-Ms, Honglin Liu, Yitao Zeng, Xin Zhao, Huarong Tong

Journal of Food and Drug Analysis

In this work, the stable isotope ratios of carbon, nitrogen, hydrogen, oxygen, and mineral elements and their stoichiometric methods were examined as possible factors that could certify Chinese tea based on its production years. A total of 43 multi-element stable isotope ratios of Xiangzhujing Pu'er tea in five production years were determined through inductively coupled plasma mass spectrometry (ICP-MS) and elemental analyzer-isotope ratio mass spectrometry (EA-IRMS) methods. Two unsupervised learning techniques (principal component analysis and hierarchical clustering analysis) and three supervised learning techniques (partial least squares discriminant analysis [PLS-DA], back-propagation artificial neural network [BP-ANN], and linear discriminant analysis [LDA]) were …

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The Chemical Aspects Of Raman Spectroscopy: Statistical Structure-Spectrum Relationship In The Analyses Of Bioflavonoids, Chih-Hsien Wang, Chia-Chi Huang, Wenlung Chen, Yen-Shi Lai Jun 2020

The Chemical Aspects Of Raman Spectroscopy: Statistical Structure-Spectrum Relationship In The Analyses Of Bioflavonoids, Chih-Hsien Wang, Chia-Chi Huang, Wenlung Chen, Yen-Shi Lai

Journal of Food and Drug Analysis

Raman spectroscopy has been accepted as a useful tool for the characterization of natural products. However, to identify a specific compound in a mixture sample of natural products using Raman spectra alone is highly challenging if not impossible. We demonstrated an effective solution to such issues using a method combining statistical Raman spectroscopy and Mass spectrometry. The method was validated with a successful application to the identification of the major anthocyanin components in a purple yam (Dioscorea purpurea) extract. Of particular interest is that statistical grouping of the bioflavonoid standards that formed the database of this study was found to …

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Screening For Malachite Green Contamination On Live Fish Skin With Chewing Gum Based Viscoelastic Sers Sensor, Wan-Li Fan, Shi-Wei Yang, Dong-Mei Wang, Zheng-Jun Gong, Mei-Kun Fan Jun 2020

Screening For Malachite Green Contamination On Live Fish Skin With Chewing Gum Based Viscoelastic Sers Sensor, Wan-Li Fan, Shi-Wei Yang, Dong-Mei Wang, Zheng-Jun Gong, Mei-Kun Fan

Journal of Food and Drug Analysis

Malachite green (MG), a prohibited but still found antimicrobial in aquafarm and during live fish shipping, is a hot target in food safety screening. Herein, a novel chewing gum based flexible SERS (G-SERS) sensor was proposed for rapid sampling and detection of MG on live fish skin. The whole analysis takesmin, while the limit of detection for MG is 0.73 pg. Different from other reports, MG contaminated live fish was monitored daily with the G-SERS sensor, during which the fish was firstly raised in 0.5 ppm MG solution for one day, followed by freshwater for a week. It was found …

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Uplc-Qtof-Ms Fingerprinting Combined With Chemometrics To Assess The Solvent Extraction Efficiency, Phytochemical Variation, And Antioxidant Activities Of Beta Vulgaris L., Junyi Wang, Guddadarangavvanahally Krishnareddy Jayaprakasha, Bhimanagouda S. Patil Jun 2020

Uplc-Qtof-Ms Fingerprinting Combined With Chemometrics To Assess The Solvent Extraction Efficiency, Phytochemical Variation, And Antioxidant Activities Of Beta Vulgaris L., Junyi Wang, Guddadarangavvanahally Krishnareddy Jayaprakasha, Bhimanagouda S. Patil

Journal of Food and Drug Analysis

Accurate assays of plant antioxidants and other phytochemicals require efficient extraction conditions and enable rigorous assessments of crop varieties and production systems. This study assessed the extraction of phytochemicals and antioxidants from conventionally or organically grown red and golden beets (Beta vulgaris L.), using twenty solvent (S1eS20) mixtures containing water, methanol, and ethanol alone or with acids (ascorbic, formic, acetic). Red beetroot extracted with methanol with or without acid had the highest betanin content (2791.0 mg/g and 8222.3 mg/g of fresh weight [FW], respectively) and golden beetroot extracted with methanol/ascorbic acid/water had the highest vulgaxanthin I (193.7 mg/g and 15.0 …

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Food Preservative Sorbic Acid Deregulates Hepatic Fatty Acid Metabolism, Chia-Hui Chen, Sin-Ni Ho, Po-An Hu, Yu Ru Kou, Tzong-Shyuan Lee Jun 2020

Food Preservative Sorbic Acid Deregulates Hepatic Fatty Acid Metabolism, Chia-Hui Chen, Sin-Ni Ho, Po-An Hu, Yu Ru Kou, Tzong-Shyuan Lee

Journal of Food and Drug Analysis

Sorbic acid (SA) is one of the most commonly used food preservatives worldwide. Despite SA having no hepatotoxicity at legal dosages, its effect on hepatic lipid metabolism is still unclear. We investigated the effect of SA on hepatic lipid metabolism and its mechanism of action in C57BL/6 mice. Daily treatment with SA (1 g/kg in diet) for 4 weeks did not alter the body weight, organ weight, and blood lipids in mice. However, hepatic lipid accumulation, particularly that of triglycerides, fatty acids, and glycerol, but not cholesteryl ester and free cholesterol, was increased with SA treatment. Mechanistically, SA decreased the …

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The Potential Role Of Phenolic Compounds On Modulating Gut Microbiota In Obesity, Gow-Chin Yen, Hsin-Lin Cheng, Li-Yu Lin, Shiuan-Chih Chen, Chin Lin Hsu Jun 2020

The Potential Role Of Phenolic Compounds On Modulating Gut Microbiota In Obesity, Gow-Chin Yen, Hsin-Lin Cheng, Li-Yu Lin, Shiuan-Chih Chen, Chin Lin Hsu

Journal of Food and Drug Analysis

Obesity is a rising public health issue and challenge which is tightly correlated with socio-economic development paralleled with increased energy intake and sedentary behavior that subsequently cause adipose tissue accumulation. Physiological and metabolic status changes during obesity development have been suggested with low grade inflammation of gastrointestinal tract. The gut microbiota plays an essential role in regulating whole body energy metabolism and also lipid accumulation, and immunity of host. However, the detail mechanism of which the gut microbiota composition influence obesity development in humans still need deeper investigation owing to the complex pathophysiology of such disease. Recently, the consumption of …

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Toxicity Studies Of 1'-S-1'-Acetoxychavicol Acetate In Rat Model, Ali Abdalla Yasir Osman Jun 2020

Toxicity Studies Of 1'-S-1'-Acetoxychavicol Acetate In Rat Model, Ali Abdalla Yasir Osman

Student Works (2020-2029)

Natural compounds are the main source of therapeutic molecules for various diseases in this era, and most of the current medicines are derived from plants, microorganisms or animals. Nevertheless, the safety profile of these natural compounds has to be confirmed prior to their medicinal use. 1'-S-1'-acetoxychavicol acetate (ACA), a type of phenylpropanoid extracted from Alpinia conchigera Griff., is one of the natural compounds being investigated for its potential therapeutic purposes. ACA was previously reported to reduce tumour volume in athymic mice at the effective dose of 1.56 mg/kg body weight intraperitoneally and induce apoptotic death of tumour cells through the …

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Association Of Long-Term Consumption Of Repeatedly Heated Mix Vegetable Oils In Different Doses And Hepatic Toxicity Through Fat Accumulation, Gul Ambreen, Afshan Siddiq, Kashif Hussain Apr 2020

Association Of Long-Term Consumption Of Repeatedly Heated Mix Vegetable Oils In Different Doses And Hepatic Toxicity Through Fat Accumulation, Gul Ambreen, Afshan Siddiq, Kashif Hussain

Department of Biological & Biomedical Sciences

Background: Hepatic diseases are one of the chief reasons for worldwide morbidity and mortality. The increased incidence in Asian countries is driving researchers to explore preventive ways from nature. It is more practical to go with healthy routine edibles like vegetable oils to avoid environmental and chemical hepatic injuries. With the use of thermally oxidized oils overproduction of reactive oxygen species (ROS) with overwhelmed cellular antioxidants defense system results in oxidative stress, the known cause of cardiovascular diseases (CVDs), cancers and neurodegenerative disorders. Little is investigated about the effect of daily used oxidized cooking oils on hepatic function changes with …

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Natural Sources And Bioactivities Of 2,4-Di-Tert-Butylphenol And Its Analogs, Fuqiang Zhao, Ping Wang, Rima D. Lucardi, Zushang Su, Shiyou Li Jan 2020

Natural Sources And Bioactivities Of 2,4-Di-Tert-Butylphenol And Its Analogs, Fuqiang Zhao, Ping Wang, Rima D. Lucardi, Zushang Su, Shiyou Li

NCPC Publications and Patents

2,4-Di-tert-butylphenol or 2,4-bis(1,1-dimethylethyl)-phenol (2,4-DTBP) is a common toxic secondary metabolite produced by various groups of organisms. The biosources and bioactivities of 2,4-DTBP have been well investigated, but the phenol has not been systematically reviewed. This article provides a comprehensive review of 2,4-DTBP and its analogs with emphasis on natural sources and bioactivities. 2,4-DTBP has been found in at least 169 species of bacteria (16 species, 10 families), fungi (11 species, eight families), diatom (one species, one family), liverwort (one species, one family), pteridiphyta (two species, two families), gymnosperms (four species, one family), dicots (107 species, 58 families), monocots (22 species, …

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Phytoremediation Potential Of Four Heavy Metals In Soil By Chromolaena Odorata (L.) King & Robinson At The Phytotoxicity Screening Benchmarks, Gloria O. Omoregie, Beckley Ikhajiagbe, Geoffery O. Anoliefo Dec 2019

Phytoremediation Potential Of Four Heavy Metals In Soil By Chromolaena Odorata (L.) King & Robinson At The Phytotoxicity Screening Benchmarks, Gloria O. Omoregie, Beckley Ikhajiagbe, Geoffery O. Anoliefo

Tanzania Journal of Science

The remediative capacity of Chromolaena odorata with respect to heavy metal induced growth-stress was investigated. This was with a view to providing information on the adaptive mechanisms adopted by the test plant during the phytoremediation of selected heavy metals such as copper, manganese, zinc and cadmium. Stems of C. odorata were planted in soils polluted with  Mn, Zn, Cd, and Cu at the ecological screening benchmark (ESB) of 50 mg/kg (Mn and Zn), 4 mg/kg (Cd) and 100 mg/kg (Cu) of metal per kilogram of soil, in varying concentrations of 0 ESB (control), 1 ESB, 3 ESB and 5 ESB. …

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Sustainable Solutions, Fall/Winter 2020, Issue 41 Nov 2019

Sustainable Solutions, Fall/Winter 2020, Issue 41

Sustain Magazine

No abstract provided.

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Environmentally Responsible Land Use, Spring/Summer 2010, Issue 22 Sep 2019

Environmentally Responsible Land Use, Spring/Summer 2010, Issue 22

Sustain Magazine

No abstract provided.

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Sustainable Communities, Fall/Winter 2010, Issue 21 Sep 2019

Sustainable Communities, Fall/Winter 2010, Issue 21

Sustain Magazine

No abstract provided.

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Sustainable Building, Spring/Summer 2009, Issue 20 Sep 2019

Sustainable Building, Spring/Summer 2009, Issue 20

Sustain Magazine

No abstract provided.

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Environmental History, Fall/Winter 2009, Issue 19 Sep 2019

Environmental History, Fall/Winter 2009, Issue 19

Sustain Magazine

No abstract provided.

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