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Articles 811 - 840 of 1074

Full-Text Articles in Medicinal Chemistry and Pharmaceutics

A New Strategy For Choosing “Q-Markers” Via Network Pharmacology, Application To The Quality Control Of A Chinese Medical Preparation, W. Xiang, T.-C. Suo, H. Yu, A.-P. Li, S.-Q. Zhang, C.-H. Wang, Y. Zhu, Z. Li Jul 2020

A New Strategy For Choosing “Q-Markers” Via Network Pharmacology, Application To The Quality Control Of A Chinese Medical Preparation, W. Xiang, T.-C. Suo, H. Yu, A.-P. Li, S.-Q. Zhang, C.-H. Wang, Y. Zhu, Z. Li

Journal of Food and Drug Analysis

Due to its chemical complexity, proper quality control for a Chinese medical preparation (CMP) has been a great challenge. Choosing the appropriate quality markers (Q-markers) for quality control of CMP is an important work. Best of all, the chosen Q-markers are the main chemical compounds from the herbals as well as the active constituents of this CMP. Only in this way the established quality control system can really achieve the purpose of controlling the quality of CMP and ensuring the safely and effectively use of CMP. To achieve the purpose, network pharmacology combined with the contents of chemical compounds in …

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Rapid Screening Of Toxic Glycoalkaloids And Micronutrients In Edible Nightshades (Solanum Spp.), B. Yuan, D. Byrnes, D. Giurleo, T. Villani, J.E. Simon, Q. Wu Jul 2020

Rapid Screening Of Toxic Glycoalkaloids And Micronutrients In Edible Nightshades (Solanum Spp.), B. Yuan, D. Byrnes, D. Giurleo, T. Villani, J.E. Simon, Q. Wu

Journal of Food and Drug Analysis

African indigenous vegetables (AIVs) because of their nutrient density have the unique potential to reduce micronutrient deficiencies in sub-Saharan Africa, yet some may also contain anti-nutritive compounds. Vegetable nightshades from Solanum americanum, Solanum nigrum, Solanum scabrum and Solanum villosum are among the major AIVs used as a leafy vegetables and consumed regularly in many countries in sub-Sahara Africa. These under-recognized food crops have not been subjected to extensive studies for their nutritional and antinutritive factors. In this study, 15 entries of the vegetable nightshades were field-grown and the leaves which are the consumed product of commerce chemically profiled by LC/ESI-MS. …

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Antibacterial Activity Of Propolins From Taiwanese Green Propolis, Y.-W. Chen, S.-R. Ye, C. Ting, Y.-H. Yu Jul 2020

Antibacterial Activity Of Propolins From Taiwanese Green Propolis, Y.-W. Chen, S.-R. Ye, C. Ting, Y.-H. Yu

Journal of Food and Drug Analysis

Taiwanese green propolis is a prenylated flavonoid rich honeybee product and propolins isolated from Taiwanese green propolis exert a broad spectrum of biological activities, such as anti-cancer and anti-oxidant. However, the anti-bacterial effects of Taiwanese green propolis or propolins are still poorly understood. In the current study, the antibacterial effects of Taiwanese green propolis and propolins were evaluated. Results show that the maximum dry matter yields of Taiwanese green propolis were observed in the 95% and 99.5% ethanol extracts compared to other extraction methods. Consistently, the highest concentration of propolins C, D, F and G from Taiwanese green propolis was …

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Modified Quechers Method For 24 Plant Growth Regulators In Grapes Using Lc-Ms/Ms, C.-H. Pu, S.-K. Lin, W.-C. Chuang, T.-H. Shyu Jul 2020

Modified Quechers Method For 24 Plant Growth Regulators In Grapes Using Lc-Ms/Ms, C.-H. Pu, S.-K. Lin, W.-C. Chuang, T.-H. Shyu

Journal of Food and Drug Analysis

A multiresidue analytical method was developed for grapes for the following 24 plant growth regulators: 1-naphthylacetamide, 2,3,5-triiodobenzoic acid, 2,4,5-T, 2-naphthoxyacetic acid, 3-indolylacetic acid, 4-(3-indolyl)-butyric acid, 4-chlorophenoxyacetic acid, 4-nitrophenol, 6-benzylaminopurine, N6-isopentenyladenine, butralin, chlormequat chloride, chlorphonim-Cl, cloprop, forchlorfenuron, gibberellic acid 3, gibberellic acid 4, gibberellic acid 7, inabenfide, mepiquat chloride, paclobutrazol, prohydrojasmon, thidiazuron and uniconizole-P. The compounds were extracted from grape samples using an extraction method modified from the Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) method. Liquid chromatography – tandem mass spectrometry was used for the detection and quantification of the compounds. Validation of the method was performed by using …

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In Vitro And In Vivo Assessment Of Delivery Of Hydrophobic Molecules And Plasmid Dnas With Peo–Ppo–Peo Polymeric Micelles On Cornea, F. Hsiao, P.-Y. Huang, T. Aoyagi, S.-F. Chang, J. Liaw Jul 2020

In Vitro And In Vivo Assessment Of Delivery Of Hydrophobic Molecules And Plasmid Dnas With Peo–Ppo–Peo Polymeric Micelles On Cornea, F. Hsiao, P.-Y. Huang, T. Aoyagi, S.-F. Chang, J. Liaw

Journal of Food and Drug Analysis

The stability and bio-distribution of genes or drug complexes with poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO–PPO–PEO, Pluronic F-68) polymeric micelles (PM) are essential for an effective nanosized PM delivery system. We used Förster resonance energy transfer (FRET) pairs with PM and measured the FRET ratio to assess the stability of PM in vitro and in vivo on the cornea. The FRET ratio reached a plateau at 0.8 with 3% PM. Differential scanning calorimetry measurement confirmed the complex formation of FRET pairs with PM. Confocal imaging with the fluorophores fluorescein isothiocyanate isomer I (FITC) and rhodamine B base (RhB) also showed the …

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Ultra-Sensitive Electrochemical Sensing Of Acetaminophen And Codeine In Biological Fluids Using Cuo/Cufe 2 O 4 Nanoparticles As A Novel Electrocatalyst, F. Hasanpour, M. Taei, S. Tahmasebi Jul 2020

Ultra-Sensitive Electrochemical Sensing Of Acetaminophen And Codeine In Biological Fluids Using Cuo/Cufe 2 O 4 Nanoparticles As A Novel Electrocatalyst, F. Hasanpour, M. Taei, S. Tahmasebi

Journal of Food and Drug Analysis

Copper ferrite−copper oxide (CuO-CuFe 2 O 4 ) nanoparticles as a semiconductor composite with p–n junction were synthesized by co-precipitation reaction. Then, a novel CuO-CuFe 2 O 4 carbon paste modified electrode was fabricated which displays an effectual electrocatalytic response to the oxidation of acetaminophen (AC) and codeine (CO). A linear range of 0.01–1.5 μmol L −1 and 0.06–10.0 μmol L −1 with the detection limits of 0.007 μmol L −1 and 0.01 μmol L −1 were achieved for AC and CO, respectively. The practical usage of the proposed sensor revealed reasonable results for quantification of AC and CO in …

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Immunochemical Assay With Monoclonal Antibodies For Detection Of Staphylococcal Enterotoxin H, N.V. Rudenko, A.P. Karatovskaya, A.N. Noskov, A.O. Shepelyakovskaya, M.P. Shchannikova, I.V. Loskutova, O.A. Artyemieva, D.A. Nikanova, E.A. Gladyr, F.A. Brovko Jul 2020

Immunochemical Assay With Monoclonal Antibodies For Detection Of Staphylococcal Enterotoxin H, N.V. Rudenko, A.P. Karatovskaya, A.N. Noskov, A.O. Shepelyakovskaya, M.P. Shchannikova, I.V. Loskutova, O.A. Artyemieva, D.A. Nikanova, E.A. Gladyr, F.A. Brovko

Journal of Food and Drug Analysis

Staphylococcal enterotoxins cause food poisoning of various degrees of severity. For milk and meat products, there is a high probability of contamination with staphylococcal enterotoxin H (SEH). In this regard specific and sensitive methods are required to be developed for its detection and monitoring. In this work, the gene seh was expressed and a preparation of recombinant toxin was obtained. Using hybridoma technology, a panel of high-affinity monoclonal antibodies (mAbs) to SEH was produced. The antibodies were characterized and shown to have no cross-reactivity towards the main staphylococcal enterotoxins (A, B, C1, D, E, G and I). Based on these …

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Regulatory Analysis On The Medical Use Of Ephedrine-Related Products In Taiwan, W.-N. Yu, L.-H. Wang, H.-W. Cheng Jul 2020

Regulatory Analysis On The Medical Use Of Ephedrine-Related Products In Taiwan, W.-N. Yu, L.-H. Wang, H.-W. Cheng

Journal of Food and Drug Analysis

To prevent ephedrine-related products from being misused to produce amphetamine and/or its analogs, there's a need for more effective and achievable regulatory mechanisms for the health, police, investigational, prosecution and judiciary authorities in Taiwan. This review was conducted to evaluate the international and Taiwan's regulatory policies and management of medical ephedrine-related products through the corresponding information collected from international and Taiwan government agency authorities. The combat of illegal drugs should involve both supply and demand sides to be successful. Health authorities in Taiwan do not have the investigational power to manage the forbidden transformation, abusing and manufacture of the illegal …

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Effects Of Vinegar–Egg On Growth Inhibition, Differentiation Human Leukemic U937 Cells And Its Immunomodulatory Activity, S.-Y. Wang, C.-Y. Chang, C.-W. Chen Jul 2020

Effects Of Vinegar–Egg On Growth Inhibition, Differentiation Human Leukemic U937 Cells And Its Immunomodulatory Activity, S.-Y. Wang, C.-Y. Chang, C.-W. Chen

Journal of Food and Drug Analysis

Vinegar and eggs have rich nutrients. In this study, the mixed form of both derived products, vinegar–egg solution and its products (vinegar–egg concentrate and vinegar–egg condensate) were chosen for an assessment of their biological activity. To further our understanding regarding the anticancer and immunomodulatory effects of vinegar–egg, we investigated its effects on the proliferation and differentiation of U937 cells. Vinegar–egg was treated using spray drying, freeze drying and vacuum concentration and used to stimulate human mononuclear cells. The conditioned media obtained from these cultures by filtration were used to treat U937 cells. Three conditioned media inhibited U937 cell growth by …

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Association Of Antioxidant Nutraceuticals And Acetaminophen (Paracetamol): Friend Or Foe?, M. Abdel-Daim, A.I. Abushouk, R. Reggi, N.S. Yarla, M. Palmery, I. Peluso Jul 2020

Association Of Antioxidant Nutraceuticals And Acetaminophen (Paracetamol): Friend Or Foe?, M. Abdel-Daim, A.I. Abushouk, R. Reggi, N.S. Yarla, M. Palmery, I. Peluso

Journal of Food and Drug Analysis

Acetaminophen (paracetamol or APAP) is an analgesic and antipyretic drug that can induce oxidative stress-mediated hepatotoxicity at high doses. Several studies reported that antioxidant nutraceuticals, in particular phenolic phytochemicals from dietary food, spices, herbs and algae have hepatoprotective effects. Others, however, suggested that they may negatively impact the metabolism, efficacy and toxicity of APAP. The aim of this review is to discuss the pros and cons of the association of antioxidant nutraceuticals and APAP by reviewing the in vivo evidence, with particular reference to APAP pharmacokinetics and hepatotoxicity. Results from the murine models of APAP-induced hepatotoxicity showed amelioration of liver …

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Nanoparticle Based Bio-Bar Code Technology For Trace Analysis Of Aflatoxin B1 In Chinese Herbs, Y.-Y. Yu, Y.-Y. Chen, X. Gao, Y.-Y. Liu, H.-Y. Zhang, T.-Y. Wang Jul 2020

Nanoparticle Based Bio-Bar Code Technology For Trace Analysis Of Aflatoxin B1 In Chinese Herbs, Y.-Y. Yu, Y.-Y. Chen, X. Gao, Y.-Y. Liu, H.-Y. Zhang, T.-Y. Wang

Journal of Food and Drug Analysis

A novel and sensitive assay for aflatoxin B1 (AFB1) detection has been developed by using bio-bar code assay (BCA). The method that relies on polyclonal antibodies encoded with DNA modified gold nanoparticle (NP) and monoclonal antibodies modified magnetic microparticle (MMP), and subsequent detection of amplified target in the form of bio-bar code using a fluorescent quantitative polymerase chain reaction (FQ-PCR) detection method. First, NP probes encoded with DNA that was unique to AFB1, MMP probes with monoclonal antibodies that bind AFB1 specifically were prepared. Then, the MMP-AFB1-NP sandwich compounds were acquired, dehybridization of the oligonucleotides on the nanoparticle surface allows …

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Comprehensive Two-Dimensional Aptes-Decorated Mcf7-Cell Membrane Chromatographic System For Characterizing Potential Anti-Breast-Cancer Components From Yuanhu–Baizhi Herbal Medicine Pair, X.-Y. Wang, X. Ding, Y.-F. Yuan, L.-Y. Zheng, Y. Cao, Z.-Y. Zhu, G.-Q. Zhang, Y.-F. Chai, X.-F. Chen, Z.-Y. Hong Jul 2020

Comprehensive Two-Dimensional Aptes-Decorated Mcf7-Cell Membrane Chromatographic System For Characterizing Potential Anti-Breast-Cancer Components From Yuanhu–Baizhi Herbal Medicine Pair, X.-Y. Wang, X. Ding, Y.-F. Yuan, L.-Y. Zheng, Y. Cao, Z.-Y. Zhu, G.-Q. Zhang, Y.-F. Chai, X.-F. Chen, Z.-Y. Hong

Journal of Food and Drug Analysis

Rhizoma corydalis and Radix Angelicae Dahurica (Yuanhu–Baizhi) herbal medicine pair has been used for thousands of years and has been reported to be potentially active in recent cancer therapy. But the exact active components or fractions remain unclear. In this study, a new comprehensive two-dimensional (2D) 3-aminopropyltriethoxysilane (APTES)-decorated MCF7-cell membrane chromatography (CMC)/capcell-C18 column/time-of-flight mass spectrometry system was established for screening potential active components and clarifying the active fraction of Yuanhu–Baizhi pair. APTES was modified on the surface of silica, which can provide an amino group to covalently link cell membrane fragments with the help of glutaraldehyde in order to improve …

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Pxr As A Mediator Of Herb–Drug Interaction, B.C. Hogle, X. Guan, M.M. Folan, W. Xie Jul 2020

Pxr As A Mediator Of Herb–Drug Interaction, B.C. Hogle, X. Guan, M.M. Folan, W. Xie

Journal of Food and Drug Analysis

Medicinal herbs have been a part of human medicine for thousands of years. The herb–drug interaction is an extension of drug–drug interaction, in which the consumptions of herbs cause alterations in the metabolism of drugs the patients happen to take at the same time. The pregnane X receptor (PXR) has been established as one of the most important transcriptional factors that regulate the expression of phase I enzymes, phase II enzymes, and drug transporters in the xenobiotic responses. Since its initial discovery, PXR has been implicated in multiple herb–drug interactions that can lead to alterations of the drug's pharmacokinetic properties …

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Transporter-Mediated Interaction Of Indican And Methotrexate In Rats, S.-P. Lin, C.-P. Yu, Y.-C. Hou, C.-Y. Huang, L.-C. Ho, S.-L. Chan Jul 2020

Transporter-Mediated Interaction Of Indican And Methotrexate In Rats, S.-P. Lin, C.-P. Yu, Y.-C. Hou, C.-Y. Huang, L.-C. Ho, S.-L. Chan

Journal of Food and Drug Analysis

Indican (indoxyl-β-D-glucoside) is present in several Chinese herbs e.g. Isatis indigotica, Polygonum tinctorium and Polygonum perfoliatum. The major metabolite of indican was indoxyl sulfate (IS), an uremic toxin which was a known substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4. Methotrexate (MTX), an important immunosuppressant with narrow therapeutic window, is a substrate of OAT 1, 2, 3, 4 and MRP 1, 2, 3, 4. We hypothesized that IS, the major metabolite of oral indican, might inhibit the renal excretion of MTX mediated by OAT 1, OAT 3 and MRP 4. Therefore, this study …

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Transporter-Mediated Natural Product–Drug Interactions For The Treatment Of Cardiovascular Diseases, W. Zha Jul 2020

Transporter-Mediated Natural Product–Drug Interactions For The Treatment Of Cardiovascular Diseases, W. Zha

Journal of Food and Drug Analysis

The growing use of natural products in cardiovascular (CV) patients has been greatly raising the concerns about potential natural product–CV drug interactions. Some of these may lead to unexpected cardiovascular adverse effects and it is, therefore, essential to identify or predict potential natural product–CV drug interactions, and to understand the underlying mechanisms. Drug transporters are important determinants for the pharmacokinetics of drugs and alterations of drug transport has been recognized as one of the major causes of natural product–drug interactions. In last two decades, many CV drugs (e.g., angiotensin II receptor blockers, beta-blockers and statins) have been identified to be …

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Activation Of P-Glycoprotein And Cyp 3a By Coptidis Rhizoma In Vivo: Using Cyclosporine As A Probe Substrate In Rats, C.-P. Yu, C.-Y. Huang, S.-P. Lin, Y.-C. Hou Jul 2020

Activation Of P-Glycoprotein And Cyp 3a By Coptidis Rhizoma In Vivo: Using Cyclosporine As A Probe Substrate In Rats, C.-P. Yu, C.-Y. Huang, S.-P. Lin, Y.-C. Hou

Journal of Food and Drug Analysis

Coptidis Rhizoma (CR), the rhizome of Coptis chinensis FRANCH, is a popular Chinese herb. CR contains plenty of isoquinoline alkaloids such as berberine, coptisine and palmatine. Cyclosporine (CSP), an important immunosuppressant with narrow therapeutic window, is employed as a probe substrate of P-glycoprotein (P-gp) and CYP3A4 in order to investigate the in vivo modulation effect of CR on P-gp and CYP3A4. Three groups of rats were orally administered CSP without and with single dose or repeated dosing of CR in a parallel design. Blood samples were collected at specific time points and the blood CSP concentration was determined by a …

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Risk Undermined In The Bilateral Pharmaceutical Regulatory System In Taiwan, H.-P. Wang, C.-L. Wang Jul 2020

Risk Undermined In The Bilateral Pharmaceutical Regulatory System In Taiwan, H.-P. Wang, C.-L. Wang

Journal of Food and Drug Analysis

The concept of Pharmacovigilance Planning and Risk Minimization Planning (PVP/RMP), initiated by the International Conference on Harmonization (ICH), addressed an important conceptual change from monitoring the safety of individual medicine to proactively conducting risk prevention for the minimization of medication error. However, the implementation of PVP/RMP is a challenge in societies like Taiwan where irrational medication and co-medication is prevalent. It is even more difficult in Taiwan where two regulatory bodies are governing pharmaceutical affairs, namely Taiwan Food and Drug Administration (TFDA) in charge of Western Medicine (WM) and the Department of Chinese Medicine and Pharmacy (DCMP) in charge of …

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Excipient-Drug Pharmacokinetic Interactions: Effect Of Disintegrants On Efflux Across Excised Pig Intestinal Tissues, W. Gerber, J.H. Hamman, J.D. Steyn Jul 2020

Excipient-Drug Pharmacokinetic Interactions: Effect Of Disintegrants On Efflux Across Excised Pig Intestinal Tissues, W. Gerber, J.H. Hamman, J.D. Steyn

Journal of Food and Drug Analysis

Pharmaceutical excipients were designed originally to be pharmacologically inert. However, certain excipients were found to have altering effects on drug pharmacodynamics and/or pharmacokinetics. Pharmacokinetic interactions may be caused by modulation of efflux transporter proteins, intercellular tight junctions and/or metabolic enzyme amongst others. In this study, five disintegrants from different chemical classes were evaluated for P-glycoprotein (P-gp) related inhibition and tight junction modulation effects. Bi-directional transport studies of the model compound, Rhodamine 123 (R123) were conducted in the absence (control group) and presence (experimental groups) of four concentrations of each selected disintegrant across excised pig jejunum tissue. The results showed that …

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Update Of Green Tea Interactions With Cardiovascular Drugs And Putative Mechanisms, J.P. Werba, S. Misaka, M.G. Giroli, K. Shimomura, M. Amato, N. Simonelli, L. Vigo, E. Tremoli Jul 2020

Update Of Green Tea Interactions With Cardiovascular Drugs And Putative Mechanisms, J.P. Werba, S. Misaka, M.G. Giroli, K. Shimomura, M. Amato, N. Simonelli, L. Vigo, E. Tremoli

Journal of Food and Drug Analysis

Many patients treated with cardiovascular (CV) drugs drink green tea (GT), either as a cultural tradition or persuaded of its putative beneficial effects for health. Yet, GT may affect the pharmacokinetics and pharmacodynamics of CV compounds. Novel GT-CV drug interactions were reported for rosuvastatin, sildenafil and tacrolimus. Putative mechanisms involve inhibitory effects of GT catechins at the intestinal level on influx transporters OATP1A2 or OATP2B1 for rosuvastatin, on CYP3A for sildenafil and on both CYP3A and the efflux transporter p-glycoprotein for tacrolimus. These interactions, which add to those previously described with simvastatin, nadolol and warfarin, might lead, in some cases, …

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Food-Drug Interactions Precipitated By Fruit Juices Other Than Grapefruit Juice: An Update Review, M. Chen, S.-Y. Zhou, E. Fabriaga, P.-H. Zhang, Q. Zhou Jul 2020

Food-Drug Interactions Precipitated By Fruit Juices Other Than Grapefruit Juice: An Update Review, M. Chen, S.-Y. Zhou, E. Fabriaga, P.-H. Zhang, Q. Zhou

Journal of Food and Drug Analysis

This review addressed drug interactions precipitated by fruit juices other than grapefruit juice based on randomized controlled trials (RCTs). Literature was identified by searching PubMed, Cochrane Library, Scopus and Web of Science till December 30 2017. Among 46 finally included RCTs, six RCTs simply addressed pharmacodynamic interactions and 33 RCTs studied pharmacokinetic interactions, whereas seven RCTs investigated both pharmacokinetic and pharmacodynamic interactions. Twenty-two juice-drug combinations showed potential clinical relevance. The beneficial combinations included orange juice-ferrous fumarate, lemon juice-99mTc-tetrofosmin, pomegranate juice-intravenous iron during hemodialysis, cranberry juice-triple therapy medications for H. pylori, blueberry juice-etanercept, lime juice-antimalarials, and wheat grass juice-chemotherapy. The potential …

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Volatile Sulfur Compounds In Tropical Fruits, R.J. Cannon, C.-T. Ho Jul 2020

Volatile Sulfur Compounds In Tropical Fruits, R.J. Cannon, C.-T. Ho

Journal of Food and Drug Analysis

Global production and demand for tropical fruits continues to grow each year as consumers are enticed by the exotic flavors and potential health benefits that these fruits possess. Volatile sulfur compounds (VSCs) are often responsible for the juicy, fresh aroma of tropical fruits. This poses a challenge for analytical chemists to identify these compounds as most often VSCs are found at low concentrations in most tropical fruits. The aim of this review is to discuss the extraction methods, enrichment techniques, and instrumentation utilized to identify and quantify VSCs in natural products. This will be followed by a discussion of the …

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A Regulatory Science Viewpoint On Botanical–Drug Interactions, M. Grimstein, S.-M. Huang Jul 2020

A Regulatory Science Viewpoint On Botanical–Drug Interactions, M. Grimstein, S.-M. Huang

Journal of Food and Drug Analysis

There is a continued predisposition of concurrent use of drugs and botanical products. Consumers often self-administer botanical products without informing their health care providers. The perceived safety of botanical products with lack of knowledge of the interaction potential poses a challenge for providers and both efficacy and safety concerns for patients. Botanical–drug combinations can produce untoward effects when botanical constituents modulate drug metabolizing enzymes and/or transporters impacting the systemic or tissue exposure of concomitant drugs. Examples of pertinent scientific literature evaluating the interaction potential of commonly used botanicals in the US are discussed. Current methodologies that can be applied to …

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General Survey Of Fructus Psoraleae From The Different Origins And Chemical Identification Of The Roasted From Raw Fructus Psoraleae, J. Yang, J. Yang, J. Du, Y. Feng, X. Chai, M. Xiao, Y. Wang, X. Gao Jul 2020

General Survey Of Fructus Psoraleae From The Different Origins And Chemical Identification Of The Roasted From Raw Fructus Psoraleae, J. Yang, J. Yang, J. Du, Y. Feng, X. Chai, M. Xiao, Y. Wang, X. Gao

Journal of Food and Drug Analysis

Fructus Psoraleae, a traditional Chinese medicine, is widely used for preventing and treating various diseases such as vitiligo, osteoporosis and psoriasis. Coumarin, such as psoralenoside, isopsoralenoside, psoralen and isopsoralen, are important compounds in Fructus Psoraleae. In our study, ultra performance liquid chromatography coupled with diode array detector was employed for an excellent method validation for simultaneous quantification of psoralenoside, isopsoralenoside, psoralen and isopsoralen, which was further applied in performing general survey of Fructus Psoraleae from the different origins and chemical identification of the roasted from raw Fructus Psoraleae in the light of illuminating the transformed rule of psoralenoside and isopsoralenoside. …

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Oxidative Stress Evoked Damages Leading To Attenuated Memory And Inhibition Of Nmdar–Camkii–Erk/Creb Signalling On Consumption Of Aspartame In Rat Model, A. Iyaswamy, A.K. Kammella, C. Thavasimuthu, W. Wankupar, W. Dapkupar, S. Shanmugam, R. Rajan, S. Rathinasamy Jul 2020

Oxidative Stress Evoked Damages Leading To Attenuated Memory And Inhibition Of Nmdar–Camkii–Erk/Creb Signalling On Consumption Of Aspartame In Rat Model, A. Iyaswamy, A.K. Kammella, C. Thavasimuthu, W. Wankupar, W. Dapkupar, S. Shanmugam, R. Rajan, S. Rathinasamy

Journal of Food and Drug Analysis

Many controversial reports are available on the use of aspartame as it releases methanol as one of its metabolite during metabolism. The present study proposes to investigate whether long term (90 days) aspartame (40 mg/kg b.wt) administration could induce oxidative stress and alter the memory in Wistar strain male albino rats. To mimic the human methanol metabolism, methotrexate (MTX)-treated rats were included as a model to study the effects of aspartame. Wistar strain albino rats were administered with aspartame (40 mg/kg b.wt) orally and studied along with controls and MTX-treated controls. Aspartame interfered in the body weight and corticosterone levels …

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Mulberry Leaf Extracts Prevent Obesity-Induced Nafld With Regulating Adipocytokines, Inflammation And Oxidative Stress, C.-H. Peng, H.-T. Lin, D.-J. Chung, C.-N. Huang, C.-J. Wang Jul 2020

Mulberry Leaf Extracts Prevent Obesity-Induced Nafld With Regulating Adipocytokines, Inflammation And Oxidative Stress, C.-H. Peng, H.-T. Lin, D.-J. Chung, C.-N. Huang, C.-J. Wang

Journal of Food and Drug Analysis

Mulberry (Morus alba) leaf has been used in Chinese medicine as the remedy for hyperlipidemia and metabolic disorders. Recent report indicated Mulberry leaf extract (MLE) attenuated dyslipidemia and lipid accumulation in high fat diet (HFD)-fed mice. Non-alcoholic fatty liver (NAFLD) is generally considered as the liver component of metabolic syndrome. The hepatic lipid infiltration induces oxidative stress, and is associated with interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) which are regulated by the leptin and adiponectin. MLE could prevent obesity-related NAFLD via downregulating the lipogenesis enzymes while upregulating the lipolysis markers. Treatment of MLE, especially at 2%, enhanced the expression …

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Organic Solute Carrier 22 (Slc22) Family: Potential For Interactions With Food, Herbal/Dietary Supplements, Endogenous Compounds, And Drugs, R.E. Lai, C.E. Jay, D.H. Sweet Jul 2020

Organic Solute Carrier 22 (Slc22) Family: Potential For Interactions With Food, Herbal/Dietary Supplements, Endogenous Compounds, And Drugs, R.E. Lai, C.E. Jay, D.H. Sweet

Journal of Food and Drug Analysis

Many drugs, hormones, components of herbal medicines, environmental pesticides and toxins are Solute Carrier family 22 (SLC22) substrates. The last twenty years has seen great progress in determining SLC22 tissue expression profiles, membrane localization, energetics, substrate profiles and biopharmaceutical significance. However, much still remains to be answered in terms of SLC22 family member's roles in ‘normal’ physiology as compared to pathophysiological states, as well as in drug interactions that impact pharmacokinetics, efficacy and toxicity. This review begins with a brief synopsis of SLC22 family discovery, function and tissue expression. Subsequent sections provide examples establishing a role for SLC22 transporters in …

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Effects Of Processing Adjuvants On Traditional Chinese Herbs, L.-L. Chen, R. Verpoorte, H.-R. Yen, W.-H. Peng, Y.-C. Cheng, J. Chao, L.-H. Pao Jul 2020

Effects Of Processing Adjuvants On Traditional Chinese Herbs, L.-L. Chen, R. Verpoorte, H.-R. Yen, W.-H. Peng, Y.-C. Cheng, J. Chao, L.-H. Pao

Journal of Food and Drug Analysis

Processing of Chinese medicines is a pharmaceutical technique that transforms medicinal raw materials into decoction pieces for use in different therapies. Various adjuvants, such as vinegar, wine, honey, and brine, are used in the processing to enhance the efficacy and reduce the toxicity of crude drugs. Proper processing is essential to ensure the quality and safety of traditional Chinese medicines (TCMs). Therefore, sound knowledge of processing principles is crucial to the standardized use of these processing adjuvants and to facilitate the production and clinical use of decoction pieces. Many scientific reports have indicated the synergistic effects of processing mechanisms on …

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Concurrent Administration Of Anticancer Chemotherapy Drug And Herbal Medicine On The Perspective Of Pharmacokinetics, Y.-Y. Cheng, C.-H. Hsieh, T.-H. Tsai Jul 2020

Concurrent Administration Of Anticancer Chemotherapy Drug And Herbal Medicine On The Perspective Of Pharmacokinetics, Y.-Y. Cheng, C.-H. Hsieh, T.-H. Tsai

Journal of Food and Drug Analysis

With an increasing number of cancer patients seeking an improved quality of life, complementary and alternative therapies are becoming more common ways to achieve such improvements. The potential risks of concurrent administration are serious and must be addressed. However, comprehensive evidence for the risks and benefits of combining anticancer drugs with traditional herbs is rare. Pharmacokinetic investigations are an efficient way to understand the influence of concomitant remedies. Therefore, this study aimed to collect the results of pharmacokinetic studies relating to the concurrent use of cancer chemotherapy and complementary and alternative therapies. According to the National Health Insurance (NHI) database …

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Corrigendum To “Chemopreventive Effect Of Natural Dietary Compounds On Xenobiotic-Induced Toxicity” [J Food Drug Anal 25 (2017) 176–186] (S1021949816301818) (10.1016/J.Jfda.2016.10.019)), J.-C. Wu, C.-S. Lai, M.-L. Tsai, C.-T. Ho, Y.-J. Wang, M.-H. Pan Jul 2020

Corrigendum To “Chemopreventive Effect Of Natural Dietary Compounds On Xenobiotic-Induced Toxicity” [J Food Drug Anal 25 (2017) 176–186] (S1021949816301818) (10.1016/J.Jfda.2016.10.019)), J.-C. Wu, C.-S. Lai, M.-L. Tsai, C.-T. Ho, Y.-J. Wang, M.-H. Pan

Journal of Food and Drug Analysis

The affiliations of Min-Hsiung Pan were missing. The affiliations should be corrected to: fDepartment of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan gDepartment of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan hInstitute of Food Science and Technology, National Taiwan University, Taipei 10617, Taiwan © 2017

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A Novel Uv-Photolysis Approach With Acetone And Isopropyl Alcohol For The Rapid Determination Of Fluoride In Organofluorine-Containing Drugs By Spectrophotometry, V.B.K. Mullapudi, K. Dheram Jul 2020

A Novel Uv-Photolysis Approach With Acetone And Isopropyl Alcohol For The Rapid Determination Of Fluoride In Organofluorine-Containing Drugs By Spectrophotometry, V.B.K. Mullapudi, K. Dheram

Journal of Food and Drug Analysis

A UV photolysis decomposition (UVPD) method for the determination of fluoride in fluorine containing pharmaceuticals by spectrophotometry is reported. It is based on the use of high intensity UV-irradiation in the presence of a digesting solution comprising a mixture of acetone and isopropanol. For the optimization of the UVPD procedure, three bulk drugs (levofloxacin, nebivolol and efavirenz) were chosen as representatives of three diverse compounds containing a single fluorine atom, two fluorine atoms, and trifluoromethyl groups respectively. Operational conditions of the UVPD method, such as concentration and volume of reagents (acetone and isopropyl alcohol), and UV irradiation time (1–6 minutes) …

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