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2020

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Articles 61 - 90 of 1103

Full-Text Articles in Pharmacology, Toxicology and Environmental Health

Homicide And Drug Trafficking In Impoverished Communities In Brazil, Elenice De Souza Oliveira, Braulio Figueiredo Alves Da Silva, Flavio Luiz Sapori, Gabriela Gomes Cardoso Sep 2020

Homicide And Drug Trafficking In Impoverished Communities In Brazil, Elenice De Souza Oliveira, Braulio Figueiredo Alves Da Silva, Flavio Luiz Sapori, Gabriela Gomes Cardoso

Department of Justice Studies Faculty Scholarship and Creative Works

Many studies demonstrate that homicides are heavily concentrated in impoverished neighborhoods, but not all socially disadvantaged neighborhoods are hotbeds of violence. Conducted in Belo Horizonte, Brazil, this study hypothesizes that the association between high rates of homicide and impoverished areas is influenced by the emergence of a specific type of street drug-dealing common to favelas (slums). The study applies econometric techniques to police data on homicides and drug arrests from 2008 to 2011, as well as 2010 Census data, to test its hypothesis. The findings provide insight into the development of crime prevention policies in areas of high social vulnerability.

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Obesity Worsens Gulf War Illness Symptom Persistence Pathology By Linking Altered Gut Microbiome Species To Long-Term Gastrointestinal, Hepatic, And Neuronal Inflammation In A Mouse Model, Dipro Bose, Punnag Saha, Ayan Mondal, Brian Fanelli, Ratanesh K. Seth, Patricia Janulewicz, Kimberly Sullivan, Stephen Lasley, Ronnie Horner, Rita R. Colwell, Ashok K. Shetty, Nancy Klimas, Saurabh Chatterjee Sep 2020

Obesity Worsens Gulf War Illness Symptom Persistence Pathology By Linking Altered Gut Microbiome Species To Long-Term Gastrointestinal, Hepatic, And Neuronal Inflammation In A Mouse Model, Dipro Bose, Punnag Saha, Ayan Mondal, Brian Fanelli, Ratanesh K. Seth, Patricia Janulewicz, Kimberly Sullivan, Stephen Lasley, Ronnie Horner, Rita R. Colwell, Ashok K. Shetty, Nancy Klimas, Saurabh Chatterjee

Faculty Publications

Persistence of Gulf War illness (GWI) pathology among deployed veterans is a clinical challenge even after almost three decades. Recent studies show a higher prevalence of obesity and metabolic disturbances among Gulf War veterans primarily due to the existence of post-traumatic stress disorder (PTSD), chronic fatigue, sedentary lifestyle, and consumption of a high-carbohydrate/high-fat diet. We test the hypothesis that obesity from a Western-style diet alters host gut microbial species and worsens gastrointestinal and neuroinflammatory symptom persistence. We used a 5 month Western diet feeding in mice that received prior Gulf War (GW) chemical exposure to mimic the home phase obese …

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The Association Between Medication Use And Gait In Adults With Intellectual Disabilities, S. Maas, D. A.M. Festen, Thessa I.M. Hilgenkamp, A. Oppewal Sep 2020

The Association Between Medication Use And Gait In Adults With Intellectual Disabilities, S. Maas, D. A.M. Festen, Thessa I.M. Hilgenkamp, A. Oppewal

Physical Therapy Faculty Research

Background: Adults with intellectual disabilities (ID) often have polypharmacy and often use antipsychotics. Both polypharmacy and antipsychotics have a negative effect on gait in the general population, but this has not been studied in adults with ID. These negative effects may add to pre‐existing gait disturbances in adults with ID and increase the risk for adverse health outcomes in this population. Therefore, the aim of this study is to investigate the difference in gait parameters between adults with ID with and without polypharmacy and between adults with ID using and not using antipsychotics. Method: The gait parameters of 31 participants …

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Aluminum Reproductive Toxicity: A Summary And Interpretation Of Scientific Reports, Robert A. Yokel Sep 2020

Aluminum Reproductive Toxicity: A Summary And Interpretation Of Scientific Reports, Robert A. Yokel

Pharmaceutical Sciences Faculty Publications

Publications addressing aluminum (Al)-induced reproductive toxicity were reviewed. Key details were compiled in summary tables. Approximate systemic Al exposure, a measure of bioavailability, was calculated for each exposure, based on the Al percentage in the dosed Al species, Al bioavailability, and absorption time course reports for the exposure route. This was limited to laboratory animal studies because no controlled-exposure human studies were found. Intended Al exposure was compared to unintended dietary Al exposure. The considerable and variable Al content of laboratory animal diets creates uncertainty about reproductive function in the absence of Al. Aluminum-induced reproductive toxicity in female mice and …

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Corrigendum To “Physicochemical Analysis And Nonisothermal Kinetic Study Of Sertralineelactose Binary Mixtures”, Farnaz Monajjemzadeh Aug 2020

Corrigendum To “Physicochemical Analysis And Nonisothermal Kinetic Study Of Sertralineelactose Binary Mixtures”, Farnaz Monajjemzadeh

Journal of Food and Drug Analysis

No abstract provided.

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Corrigendum To “Shenmai-Yin Decreased The Clearance Of Nifedipine In Rats: The Involvement Of Time-Dependent Inhibition Of Nifedipine Oxidation”, Yune- Fang Ueng Aug 2020

Corrigendum To “Shenmai-Yin Decreased The Clearance Of Nifedipine In Rats: The Involvement Of Time-Dependent Inhibition Of Nifedipine Oxidation”, Yune- Fang Ueng

Journal of Food and Drug Analysis

No abstract provided.

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Corrigendum To “The Time-Dependent Effects Of St John's Wort On Cytochrome P450, Uridine Diphosphate-Glucuronosyltransferase, Glutathione S-Transferase, And Nad(P)H-Quinone Oxidoreductase In Mice”, Yune- Fang Ueng Aug 2020

Corrigendum To “The Time-Dependent Effects Of St John's Wort On Cytochrome P450, Uridine Diphosphate-Glucuronosyltransferase, Glutathione S-Transferase, And Nad(P)H-Quinone Oxidoreductase In Mice”, Yune- Fang Ueng

Journal of Food and Drug Analysis

No abstract provided.

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Corrigendum To “Effects Of Aqueous Extract Of Ruta Graveolens And Its Ingredients On Cytochrome P450, Uridine Diphosphate (Udp)-Glucuronosyltransferase, And Reduced Nicotinamide Adenine Dinucleotide (Phosphate) (Nad(P)H)-Quinone Oxidoreductase In Mice”, Yune- Fang Ueng Aug 2020

Corrigendum To “Effects Of Aqueous Extract Of Ruta Graveolens And Its Ingredients On Cytochrome P450, Uridine Diphosphate (Udp)-Glucuronosyltransferase, And Reduced Nicotinamide Adenine Dinucleotide (Phosphate) (Nad(P)H)-Quinone Oxidoreductase In Mice”, Yune- Fang Ueng

Journal of Food and Drug Analysis

No abstract provided.

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Acarbose Attenuates Migration/Proliferation Via Targeting Microrna-143 In Vascular Smooth Muscle Cells Under Diabetic Conditions, Wei-Yuan Chuang, Meng-Hsun Yu, Tsung-Yuan Yang, Kuei-Chuan Chan, Chau-Jong Wang Aug 2020

Acarbose Attenuates Migration/Proliferation Via Targeting Microrna-143 In Vascular Smooth Muscle Cells Under Diabetic Conditions, Wei-Yuan Chuang, Meng-Hsun Yu, Tsung-Yuan Yang, Kuei-Chuan Chan, Chau-Jong Wang

Journal of Food and Drug Analysis

Acarbose (an a-glucosidase inhibitor) has been demonstrated to reduce the progression of atherosclerosis without affecting serum levels of glucose in rabbits fed a high cholesterol diet. The main focus of recent atherosclerosis studies has been microRNA targets. However, the mechanism by which acarbose targets miRNA-mediated atherosclerosis remains unclear. This study aimed to evaluate the effect of acarbose on microRNA-related regulation of rat aortic vascular smooth cell line (A7r5 cell) migration and proliferation induced by diabetic conditions. We reported that acabose exhibit significantly inhibits proliferative and cell migration abilities in A7r5 cells. The expression of protein and levels of mRNA were …

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Effect Of 6,7-Dimethoxy-2,2-Dimethyl-2h-Chromene (Agerarin) On The Recovery Of Filaggrin Expression Through Targeting Of Janus Kinases In The Inflammatory Skin, Sung Shin Ahn, Young Han Lee, Hyunjin Yeo, Youngshim Lee, Do Sik Min, Yoongho Lim, Soon Young Shin Aug 2020

Effect Of 6,7-Dimethoxy-2,2-Dimethyl-2h-Chromene (Agerarin) On The Recovery Of Filaggrin Expression Through Targeting Of Janus Kinases In The Inflammatory Skin, Sung Shin Ahn, Young Han Lee, Hyunjin Yeo, Youngshim Lee, Do Sik Min, Yoongho Lim, Soon Young Shin

Journal of Food and Drug Analysis

Filaggrin (FLG) is a structural component of the stratum corneum that is essential for maintaining the barrier function of the skin and for the formation of natural moisturizing factors. 6,7-Dimethoxy-2,2-dimethyl-2H-chromene (Agerarin) is a bioactive compound derived from Ageratum houstonianum, a plant that is used as a traditional medicine to treat skin diseases. This study aimed to evaluate the effect of agerarin on skin inflammation in a dinitrochlorobenzene (DNCB)-induced atopic dermatitis mouse model. We found that the topical administration of agerarin ameliorates atopic dermatitis-like skin lesions. We also showed that agerarin restores the reduced filaggrin (FLG) expression in …

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Biologically-Guided Isolation Of Natural Lead Antithyroid Drug From Medicago Sativa L. Sprouts And Its Toxic Profile In Comparison With Propylthiouracil, Reham S. Ibrahim, Nesrine S. El-Mezayen, Asmaa Khairy, Hala H. Zaatout, Hala M. Hammoda, Aly M. Metwally Aug 2020

Biologically-Guided Isolation Of Natural Lead Antithyroid Drug From Medicago Sativa L. Sprouts And Its Toxic Profile In Comparison With Propylthiouracil, Reham S. Ibrahim, Nesrine S. El-Mezayen, Asmaa Khairy, Hala H. Zaatout, Hala M. Hammoda, Aly M. Metwally

Journal of Food and Drug Analysis

Hyperthyroidism is a common endocrine disorder associated with increased risk of cardiovascular complications and mortality. Although antithyroid drugs (ATDs) are approved as first line option for many hyperthyroidism cases, including pregnancy and childhood, they exert significant toxic profile. Medicago sativa L. (alfalfa) also called “The father of all food” was among the diet consumed by mares that gave birth to foals with congenital hypothyroidism. Since, greenfeed was accused for the development of such condition, alfalfa may possess constituents with promising antithyroid potential that could be a valuable substitute for the conventional ATDs. The current work was designed to identify the …

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Establishment Of Indirect Competitive Enzyme Linked Immunosorbent Assay For The Detection Of Platycodin D In Radix Platycodonis, Shuai Luo, Yanfei He, Hongxiang Sun Aug 2020

Establishment Of Indirect Competitive Enzyme Linked Immunosorbent Assay For The Detection Of Platycodin D In Radix Platycodonis, Shuai Luo, Yanfei He, Hongxiang Sun

Journal of Food and Drug Analysis

Platycodin D (PD) has been used as the quality control marker of Radix Platycodonis for its high content and various pharmacological properties. In this study, a specific polyclonal antibody against PD (PD–pAb) was developed, and PD–pAb-based indirect competitive enzyme-linked immunosorbent assay (icELISA) was established for the detection of PD in Radix Platycodonis. The 50% inhibition concentration (IC50) of PD was 2.70 μg/mL and the linearity range for PD was from 0.064 μg/mL to 100 μg/mL. No cross reactivity with PD–pAb was found in five PD analogs except for PD2 (0.93%). The average recovery of PD by icELISA was …

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Spatiotemporal Patterns Of Polychlorinated Dibenzo-P-Dioxins And Dibenzofurans And Dioxin-Like Polychlorinated Biphenyls In Foodstuffs In Air Quality Regions In Taiwan, Ching-Chang Lee, Wei-Hsiang Chang, Hsin-Tang Lin, Jung-Wei Chang Aug 2020

Spatiotemporal Patterns Of Polychlorinated Dibenzo-P-Dioxins And Dibenzofurans And Dioxin-Like Polychlorinated Biphenyls In Foodstuffs In Air Quality Regions In Taiwan, Ching-Chang Lee, Wei-Hsiang Chang, Hsin-Tang Lin, Jung-Wei Chang

Journal of Food and Drug Analysis

High-fat food intake is the main source of dioxin-like compounds for humans, such as consumption of meat, dairy and eggs, and seafood products. Fruits, vegetables, and cereals have relatively low levels of dioxin-like compounds, but because of high consumption they also contribute to the food-borne intake. It is necessary to clarify dietary dioxin exposure affected by different food contamination levels and dietary habits among different geographic areas. We aimed to evaluate chronic dietary PCDD/Fs and DL-PCBs exposure in 725 individual foods in 14 categories in 6 Taiwan air quality regions (AQRs) and a total of 2,441 foods from 2004 and …

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Quantification Of Adenosine Mono-, Di- And Triphosphate From Royal Jelly Using Liquid Chromatography - Tandem Mass Spectrometry, Wan-Rou Liao, Jen-Pang Huang, Sung-Fang Chen Aug 2020

Quantification Of Adenosine Mono-, Di- And Triphosphate From Royal Jelly Using Liquid Chromatography - Tandem Mass Spectrometry, Wan-Rou Liao, Jen-Pang Huang, Sung-Fang Chen

Journal of Food and Drug Analysis

Nucleotides are composed of nitrogen bases, ribose units and phosphate groups. Adenine (Ade), adenosine monophosphate (AMP), adenosine diphosphate (ADP) and adenosine triphosphate (ATP) all play important roles in physiological metabolism. Royal jelly, a secretion produced by worker bees, contains a variety of natural ingredients and several studies have shown that royal jelly can serve as a source of nutrition for humans. In this study, a rapid and effective LC/MS method coupled with pre-processing methods was developed and validated for the accurate quantification of Ade, AMP, ADP and ATP in royal jelly. To achieve the best extraction efficiency, two pretreatment methods, …

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Lipophilized Epigallocatechin (Egc) And Its Derivatives: Inhibition Of Oxidation Of Β-Carotene–Linoleate Oil-In-Water Emulsion And Dna Strand Scission, Priyatharini Ambigaipalan, Won Young Oh, Fereidoon Shahidi Aug 2020

Lipophilized Epigallocatechin (Egc) And Its Derivatives: Inhibition Of Oxidation Of Β-Carotene–Linoleate Oil-In-Water Emulsion And Dna Strand Scission, Priyatharini Ambigaipalan, Won Young Oh, Fereidoon Shahidi

Journal of Food and Drug Analysis

Tea epigallocatechin (EGC) was acylated with selected fatty acids, namely propionic acid [C3:0], caprylic acid [C8:0], lauric acid [C12:0], stearic acid [C18:0] and docosahexaenoic acid (DHA; C22:6 n-3). Antioxidant activity of EGC and its lipophilized derivatives were examined in various food (β-carotene–linoleate oil-in-water emulsion and bulk oil) and biological (supercoiled DNA and LDL) systems in vitro in order to evaluate the effect of increased lipophilicity on their antioxidant capacity. Lipophilized EGC derivatives were more effective in β-carotene–linoleate oil-in-water emulsion and bulk oil than their parent EGC molecule. Meanwhile, EGC and its derivatives showed more than 60 …

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Using Cold War-Era Satellite Imagery To Inform Historic Land Cover Classification, Nicholas Hamp-Adams Aug 2020

Using Cold War-Era Satellite Imagery To Inform Historic Land Cover Classification, Nicholas Hamp-Adams

The Journal of Purdue Undergraduate Research

No abstract provided.

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Comparative Developmental Toxicity Of Perfluorooctanesulfonic Acid (Pfos) And Its Alternative Perfluorobutanesulfonic Acid (Pfbs), Hanna King Aug 2020

Comparative Developmental Toxicity Of Perfluorooctanesulfonic Acid (Pfos) And Its Alternative Perfluorobutanesulfonic Acid (Pfbs), Hanna King

The Journal of Purdue Undergraduate Research

No abstract provided.

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Methylmercury Cytotoxicity On Developing Neuronal Lineages And Differences In Susceptibility Based On Media Type, Madeline Henley Aug 2020

Methylmercury Cytotoxicity On Developing Neuronal Lineages And Differences In Susceptibility Based On Media Type, Madeline Henley

The Journal of Purdue Undergraduate Research

No abstract provided.

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Discoveries In Aerosol Science: Characterization Of Nanoparticles Emitted From Metallic Coils In Electronic Cigarettes, Kaushal Prasad Aug 2020

Discoveries In Aerosol Science: Characterization Of Nanoparticles Emitted From Metallic Coils In Electronic Cigarettes, Kaushal Prasad

The Journal of Purdue Undergraduate Research

Electronic (e-) cigarettes, also known as electronic nicotine delivery systems, are battery-operated devices that are growing in popularity worldwide. Although e-cigarettes are known to be safer than traditional cigarettes, their potential health risks have not been extensively reviewed yet. In this study, aerosol nanoparticles generated from e-cigarette heaters were characterized. Kanthal A1 (iron + chromium + aluminum) coils, without nicotine solution or a wick, were installed in an e-cigarette atomizer. The operating conditions were varied coil resistances (0.1–1.0 Ω), a set applied power (10 W), and a stable duty cycle (50%: 5 s on, 5 s off ). The size …

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Ventilation & Masks: Reducing Airborne Transmission Of Covid-19 In A Classroom, Eric A. Schiff Aug 2020

Ventilation & Masks: Reducing Airborne Transmission Of Covid-19 In A Classroom, Eric A. Schiff

SyracuseCoE

We've calculated the number of COVID-19 infections that will be spread from a single COVID-19 "superspreader" to students and teachers in a classroom shared for 4 hours in different ventilation and masking conditions.

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The Effects Of Radical Containing Combustion Derived Particulate Matter In Adult Mouse Respiratory System, Jeffrey Harding Aug 2020

The Effects Of Radical Containing Combustion Derived Particulate Matter In Adult Mouse Respiratory System, Jeffrey Harding

LSU Doctoral Dissertations

Epidemiological data associates high levels of combustion-derived particulate matter (PM) with deleterious respiratory outcomes, but the mechanism underlying those outcomes remains elusive. It has been acknowledged by the World Health Organization that PM exposure contributes to more than 4.2 million all-cause mortalities worldwide each year. Current literature demonstrates that PM exacerbates respiratory diseases, impairs lung function, results in chronic respiratory illnesses, and is associated with increased mortality. The proposed mechanisms revolve around oxidative stress and inflammation promoting pulmonary physiological remodeling. Our data demonstrate that environmentally persistent free radicals (EPFRs) stabilized on the surface of PM are capable of inducing oxidative …

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A Method To Measure The Partitioning Coefficient Of Volatile Organic Compounds In Nanoparticles, Guiying Rao, Jeonghyeon Ahn, Abigail Evans, Michelle Casey, Eric P. Vejerano Aug 2020

A Method To Measure The Partitioning Coefficient Of Volatile Organic Compounds In Nanoparticles, Guiying Rao, Jeonghyeon Ahn, Abigail Evans, Michelle Casey, Eric P. Vejerano

Faculty Publications

The partitioning behavior of volatile organic compounds (VOCs) into nanoparticles is less studied compared to those of semivolatile organic compounds (SVOCs) because of the lower concentration of the VOCs that is expected to partition into particles. One challenge in measuring the accurate partition coefficient of VOCs is quantifying their low mass fraction that sorbed on nanoparticles and differentiating them from the high VOC concentrations present in the gas-phase. Systematically characterizing the partitioning coefficient at a specific environmental condition is also difficult when sampling in the field. During field sampling, thermal and non-thermal issues such as sampling artifacts and non-equilibrium conditions …

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Foliar Application Of Low Concentrations Of Titanium Dioxide And Zinc Oxide Nanoparticles To The Common Sunflower Under Field Conditions, Marek Kolenčík, Dávid Ernst, Martin Urík, Ľuba Ďurišová, Marek Bujdoš, Martin Šebesta, Edmund Dobročka, Samuel Kšiňan, Ramakanth Illa, Qian Yu, Huan Feng, Ivan Černý, Veronika Holišová, Gabriela Kratošová Aug 2020

Foliar Application Of Low Concentrations Of Titanium Dioxide And Zinc Oxide Nanoparticles To The Common Sunflower Under Field Conditions, Marek Kolenčík, Dávid Ernst, Martin Urík, Ľuba Ďurišová, Marek Bujdoš, Martin Šebesta, Edmund Dobročka, Samuel Kšiňan, Ramakanth Illa, Qian Yu, Huan Feng, Ivan Černý, Veronika Holišová, Gabriela Kratošová

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

Nano-fertilisers have only recently been introduced to intensify plant production, and there still remains inadequate scientific knowledge on their plant-related effects. This paper therefore compares the effects of two nano-fertilisers on common sunflower production under field conditions. The benefits arising from the foliar application of micronutrient-based zinc oxide fertiliser were compared with those from the titanium dioxide plant-growth enhancer. Both the zinc oxide (ZnO) and titanium dioxide (TiO2) were delivered by foliar application in nano-size at a concentration of 2.6 mg·L−1. The foliar-applied nanoparticles (NPs) had good crystallinity and a mean size distribution under 30 nm. …

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Thiamine Deficiency Causes Long-Lasting Neurobehavioral Deficits In Mice, Hui Li, Hong Xu, Wen Wen, Liying Wu, Mei Xu, Jia Luo Aug 2020

Thiamine Deficiency Causes Long-Lasting Neurobehavioral Deficits In Mice, Hui Li, Hong Xu, Wen Wen, Liying Wu, Mei Xu, Jia Luo

Pharmacology and Nutritional Sciences Faculty Publications

Thiamine deficiency (TD) has detrimental effects on brain health and neurobehavioral development, and it is associated with many aging-related neurological disorders. To facilitate TD-related neuropsychological studies, we generated a TD mouse model by feeding a thiamine-deficient diet for 30 days, followed by re-feeding the control diet for either one week or 16 weeks as recovery treatment. We then performed neurobehavioral tests in these two cohorts: cohort of one week post TD treatment (1 wk-PTDT) and 16 weeks post TD treatment (16 wks-PTDT). The TD mice showed no significant difference from control in any tests in the 1 wk-PTDT cohort at …

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Next Generation Aryl Hydantoins As Antischistosomal Agents, Derek A. Leas Aug 2020

Next Generation Aryl Hydantoins As Antischistosomal Agents, Derek A. Leas

Theses & Dissertations

Schistosomiasis, also known as “snail fever,” is both an acute and chronic disease spread by trematode flukes from the tropical parasitic worm genus Schistosoma. The flukes are spread via diseased freshwater snails, which release the parasites into the water column where they find a new human host. According to the World Health Organization (WHO), 99 million people were treated for schistosomiasis in 2017. The primary treatment used to combat schistosomiasis is the drug praziquantel (PZQ), but due to high drug pressure and widespread administration, its effectiveness has eroded because of rising drug resistance. Furthermore, PZQ is active against adult but …

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Development Of An Lc-Esi-Ms/Ms Method For Determination Of A Novel Pyrrolomycin (Mp-1) And Application To Pre-Clinical Adme Studies, Wafaa N. Aldhafiri Aug 2020

Development Of An Lc-Esi-Ms/Ms Method For Determination Of A Novel Pyrrolomycin (Mp-1) And Application To Pre-Clinical Adme Studies, Wafaa N. Aldhafiri

Theses & Dissertations

A rapid, selective, and sensitive liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method was developed and validated for quantitation of a novel Pyrrolomycin (MP-1) in mouse plasma. MP-1 was extracted from plasma utilizing a structural analog (PL-3) as the internal standard (IS). Analyte separation was achieved using a Waters Acquity UPLC®BEH C18 column (1.7 µm, 100 x 2.1 mm) protected with Acquity UPLC C18 guard column. Mobile phase consisted of 0.1% acetic acid in water (10%) and methanol (90%) at a total flow rate of 0.25 mL/min. The mass spectrometer was operated at unit resolution in the multiple reaction …

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Isolation, Structure Elucidation, And Synthesis Of Natural Products From Marine Cyanobacteria, Keren Solomon Aug 2020

Isolation, Structure Elucidation, And Synthesis Of Natural Products From Marine Cyanobacteria, Keren Solomon

Electronic Theses and Dissertations

This thesis describes the isolation, structure elucidation, and synthesis of natural products from marine cyanobacteria. A crude extract from a cyanobacterium collected in Curacao showed selective affinity for the dopamine D5 receptor in a screen against a panel of CNS receptors. Due to the high similarity of the D5 and D1 receptor, to date there are no known ligands that differentiate them. Attempts to purify the compound responsible for this affinity led to the isolation of the known compound caylobolide A. A second extract from a cyanobacterium collected in Panama underwent bioassay-guided fractionation and yielded the novel …

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Tlr Antagonism By Sparstolonin B Alters Microbial Signature And Modulates Gastrointestinal And Neuronal Inflammation In Gulf War Illness Preclinical Model, Dipro Bose, Ayan Mondal, Punnag Saha, Diana Kimono, Sutapa Sarkar, Ratanesh K. Seth, Patricia Janulewicz, Kimberly Sullivan, Ronnie Horner, Nancy Klimas, Mitzi Nagarkatti, Prakash Nagarkatti, Saurabh Chatterjee Aug 2020

Tlr Antagonism By Sparstolonin B Alters Microbial Signature And Modulates Gastrointestinal And Neuronal Inflammation In Gulf War Illness Preclinical Model, Dipro Bose, Ayan Mondal, Punnag Saha, Diana Kimono, Sutapa Sarkar, Ratanesh K. Seth, Patricia Janulewicz, Kimberly Sullivan, Ronnie Horner, Nancy Klimas, Mitzi Nagarkatti, Prakash Nagarkatti, Saurabh Chatterjee

Faculty Publications

The 1991 Persian Gulf War veterans presented a myriad of symptoms that ranged from chronic pain, fatigue, gastrointestinal disturbances, and cognitive deficits. Currently, no therapeutic regimen exists to treat the plethora of chronic symptoms though newer pharmacological targets such as microbiome have been identified recently. Toll-like receptor 4 (TLR4) antagonism in systemic inflammatory diseases have been tried before with limited success, but strategies with broad-spectrum TLR4 antagonists and their ability to modulate the host-microbiome have been elusive. Using a mouse model of Gulf War Illness, we show that a nutraceutical, derived from a Chinese herb Sparstolonin B (SsnB) presented a …

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The Use Of Ultra-High Pressure Liquid Chromatography In High-Throughput Pharmaceutical Separations, Glenn Anthony Kresge Aug 2020

The Use Of Ultra-High Pressure Liquid Chromatography In High-Throughput Pharmaceutical Separations, Glenn Anthony Kresge

Theses and Dissertations

The higher pressures and flow rates needed to increase throughput in ultra-high pressure liquid chromatography (UHPLC) can lead to thermal broadening due to viscous friction. The use of superficially porous particles and still-air thermal environments can help reduce this broadening, which is especially important in applications requiring high-throughput, isocratic separations, such as monograph methods for over-the-counter analgesics. In the first experiment discussed below, system suitability parameters (resolution and peak asymmetry) and temperature changes across the axial length of the column were monitored at conditions near column or system pressure limits. Results from this investigation indicated that shorter columns packed with …

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Determinants Of The Carbon Footprint Of German Swimmers 2020., Ann-Marie Muehlbauer Aug 2020

Determinants Of The Carbon Footprint Of German Swimmers 2020., Ann-Marie Muehlbauer

Master's Theses

The current climate situation is placing our planet and future generations at risk, which demonstrates the urgency to combat climate change and conduct research to support this effort. Calculating the carbon footprint of active sport participation represents an important opportunity to conduct additional research. This study examined the environmental attitudes and practices of swim club members in Germany. The study had three goals: First, to calculate the total and partial carbon footprint of German swimmers; second, to understand how sport organizations induce participants to engage in pro-environmental behavior; and third, to analyze various factors associated with carbon footprint, such as …

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