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Articles 61 - 90 of 153
Full-Text Articles in Pharmacology, Toxicology and Environmental Health
The Cardiovascular Effects Of Tobacco Product-Derived Aldehydes: Contribution Of Transient Receptor Potential Ankyrin-1., Lexiao Jin
Electronic Theses and Dissertations
Cardiovascular diseases (CVD) are the leading cause of death in most countries and are significant health and financial burden worldwide. Smoking contributes to more than 480,000 premature deaths annually -- accounting for one of every five deaths in the United States each year. Numerous studies have shown that smoking increases the risk of factors including endothelial dysfunction, thrombosis, and atherosclerosis, which may lead to an incidence of myocardial infarction, coronary artery disease, and stroke. Electronic cigarettes (e-cigarettes) are a new kind of tobacco product, and some studies show that e-cigarettes also could induce CVD since both e-cigarettes and conventional tobacco …
Characterizing The Roles Of Neutral Ceramidase In Cisplatin-Induced Kidney Injury., Sophia M. Sears
Characterizing The Roles Of Neutral Ceramidase In Cisplatin-Induced Kidney Injury., Sophia M. Sears
Electronic Theses and Dissertations
Cisplatin is a commonly used chemotherapeutic agent with a dose-limiting nephrotoxicity. 30% of patients given cisplatin develop acute kidney injury (AKI). AKI increases risk of chronic kidney disease (CKD) development and mortality. Patients that don’t develop clinical AKI are still at risk for long term declines in renal function. Currently, there are no FDA approved agents to treat or prevent cisplatin-induced kidney injury (CDDP-KI). In this study, we demonstrated that neutral ceramidase (nCDase) knockout provides protection from AKI in the high-dose model of CDDP-KI. However, in the repeated low dose cisplatin (RLDC) model of injury and we found nCDase knockout …
Therapeutic Potential Of Withaferin A Against Non-Small Cell Lung Cancer., Al Hassan Kyakulaga
Therapeutic Potential Of Withaferin A Against Non-Small Cell Lung Cancer., Al Hassan Kyakulaga
Electronic Theses and Dissertations
Lung cancer is the leading cause of cancer-related deaths worldwide and in the United States. Despite recent advancements in treatment approaches, chemoresistance and metastasis remain a major therapeutic challenge. Withaferin A (WFA), a plant-derived compound has recently emerged as a promising antitumor agent. In the present study, we explored the therapeutic potential of WFA against advanced NSCLC. Briefly, WFA was evaluated for its efficacy, toxicity and pharmacokinetic properties against advanced NSCLC using in vitro and in vivo models. Two human NSCLC cell lines, H1299 and A549 were used in cell culture to determine the anticancer properties of WFA. Repeat dose …
Sustainable Solutions, Fall/Winter 2020, Issue 41
Sustainable Solutions, Fall/Winter 2020, Issue 41
Sustain Magazine
No abstract provided.
Drinking Water Quality And Human Dimensions Of Cholera Patients To Inform Evidence-Based Prevention Investment In Karonga District, Malawi., Prince Kaponda, Suresh Muthukrishnan, Rory Barber, Rochelle H. Holm
Drinking Water Quality And Human Dimensions Of Cholera Patients To Inform Evidence-Based Prevention Investment In Karonga District, Malawi., Prince Kaponda, Suresh Muthukrishnan, Rory Barber, Rochelle H. Holm
Faculty and Staff Scholarship
Cholera remains a problem in sub-Saharan Africa, especially in Malawi. Our aim was to investigate drinking water source quality compared with water treatment, risk perception and cholera knowledge for patients who had reported to a health center for treatment in the 2017-2018 outbreak in Karonga District, Malawi. The study analyzed 120 drinking water samples linked to 236 cholera patients. Nearly 82% of the samples met the national criteria for thermotolerant coliforms of 50 cfu/100 ml, while 50% met the more stringent World Health Organization criteria of 0 cfu/100 ml. In terms of the human dimensions, 68% of survey respondents reported …
Environmentally Responsible Land Use, Spring/Summer 2010, Issue 22
Environmentally Responsible Land Use, Spring/Summer 2010, Issue 22
Sustain Magazine
No abstract provided.
Sustainable Communities, Fall/Winter 2010, Issue 21
Sustainable Communities, Fall/Winter 2010, Issue 21
Sustain Magazine
No abstract provided.
Sustainable Building, Spring/Summer 2009, Issue 20
Sustainable Building, Spring/Summer 2009, Issue 20
Sustain Magazine
No abstract provided.
Environmental History, Fall/Winter 2009, Issue 19
Environmental History, Fall/Winter 2009, Issue 19
Sustain Magazine
No abstract provided.
Student Research, Spring/Summer 2008, Issue 18
Evolving Pollution Prevention, Fall/Winter 2008, Issue 17
Evolving Pollution Prevention, Fall/Winter 2008, Issue 17
Sustain Magazine
No abstract provided.
Climate Change, Spring/Summer 2007, Issue 16
Our Energy Future, Fall/Winter 2007, Issue 15
Land Conservation, Spring/Summer 2006, Issue 14
Land Conservation, Spring/Summer 2006, Issue 14
Sustain Magazine
No abstract provided.
Pollution And Heart Disease, Fall/Winter 2006, Issue 13
Pollution And Heart Disease, Fall/Winter 2006, Issue 13
Sustain Magazine
No abstract provided.
Green Cities, Spring/Summer 2005, Issue 12
Global Sustainability, Fall/Winter 2005, Issue 11
Global Sustainability, Fall/Winter 2005, Issue 11
Sustain Magazine
No abstract provided.
Environmental Justice, Spring/Summer 2004, Issue 10
Environmental Justice, Spring/Summer 2004, Issue 10
Sustain Magazine
No abstract provided.
Kentucky's Environmental Future, Fall/Winter 2004, Issue 9
Kentucky's Environmental Future, Fall/Winter 2004, Issue 9
Sustain Magazine
No abstract provided.
Urban Ecology, Spring/Summer 2003, Issue 8
Urban Regeneration, Fall/Winter 2003, Issue 7
Urban Air Quality, Spring/Summer 2002, Issue 6
Sustainability Of Industrialized Agriculture, Fall/Winter 2002, Issue 5
Sustainability Of Industrialized Agriculture, Fall/Winter 2002, Issue 5
Sustain Magazine
No abstract provided.
Urban Design For Environmental Protection, Spring/Summer 2001, Issue 4
Urban Design For Environmental Protection, Spring/Summer 2001, Issue 4
Sustain Magazine
No abstract provided.
Stream Restoration, Spring/Summer 2011, Issue 24
Stream Restoration, Spring/Summer 2011, Issue 24
Sustain Magazine
No abstract provided.
Renewable Energy, Fall/Winter 2011, Issue 23
Biodiversity, Fall/Winter 2012, Issue 25
Active Transportation, Spring/Summer 2012, Issue 26
Active Transportation, Spring/Summer 2012, Issue 26
Sustain Magazine
No abstract provided.
Heat Islands, Fall/Winter 2014, Issue 29
Sustainable Behavior, Spring/Summer 2013, Issue 28
Sustainable Behavior, Spring/Summer 2013, Issue 28
Sustain Magazine
No abstract provided.