Pharmacology, Toxicology and Environmental Health Commons^™

Study Of An Analytical Method For Benzo(A)Pyrene Metabolites In Human Urine, Zheng Ouyang

Theses

A method developed by Becher and Bjorseth for analysis of PAH metabolites in urine was employed to investigate human exposure to benzo(a)pyrene (BaP) - an ubiquitous environmental carcinogen. Preliminary results are presented showing the relationship between exposure to BaP and urinary elimination. Although the correlation between the two variables is not statistically significant, there appears to be a positive association with selected exposure varibles such as smoking. The identification of an association may establish urinary BaP as a marker of exposure.

However, detailed study of the analytical procedure indicated that recoveries with this method were as low as 3-8% for …

Thermal Desorption Of Hazardous And Toxic Organic Compounds, Manuel S. Nolau

Theses

The purpose of this thesis is to study the thermal desorption behavior of toxic organic compounds, specifically o-xylene, p-xylene, ethyl benzene, p-chlorotoluene, and anthracene, from soil with respect to temperature and time, and to develop a mathematical model that will describe this desorption behavior. The model will allow prediction of the concentration of an organic contaminant in commercial soil desorption system over time given a known set of parameters of the specific chemical as well as flow rate and temperature. For this purpose, two sets of experiments were done: These are identified as 1. Thermal desorption and 2. plug flow …

Environmental Assessment In Bioethanol Technology Using Immobilized Yeast Cells, Minoo Kandy Zarnegar

Theses

This study is undertaken from the standpoint of water pollution evaluation in bioethanol technology, using immobilized yeast cells. Evaluation of water pollution caused by immobilized yeast fermentation is the main objective of this research.

The pollution in water remaining at the end of ethanol production, which is normally discharged in the wastewater stream, has been analyzed by the measurement of biological oxygen demand (BOD), since BOD measurement is one of the widely used parameters for water pollution evaluation. BOD obtained from produced water (stillage) was between the range of 115- 360 mg/l. The variation in BOD depended upon the removal …

Agenda For Action - Casco Bay, Department Of Environmental Protection

Maine Collection

Agenda For Action - Casco Bay

Department of Environmental Protection, Augusta, Maine (January, 1989)

Contents: Introduction / The Problems : Bacteria, Toxics, Nutrients / The Solutions / Recommendations / References

Maine Nonpoint Source Pollution Assessment Report, Bureau Of Water Quality Control

Maine Collection

Maine Nonpoint Source Pollution Assessment Report

Prepared by the Maine Department of Environmental Protection, Bureau of Water Quality Control, Augusta, Maine 1989.

Contents: Executive Summary / Introduction / Methodology / Statewide Water Quality Summary / State And Local Agency Programs for Control of Nonpoint Source Pollution / Process for Identification of Best Management Practices and Associated Standards / List of References / List of Figures / List of Tables

A Study Of Human Exposure To Benzo(A)Pyrene (Bap) Through Different Pathways. Part A ; Assessment Of Benzo(A)Pyrene (Bap) Exposure Through Urine Analysis With The Hydriodic Acid Reduction Reaction. Part B, Shao-Keng Liang

Theses

PART A: An investigation of total human exposure to an environmental pollutant is described. The study is being conducted in a community impacted by a foundry suspected to be a dominant local source of benzo(a)pyrene (BaP). The research aims to assess the relative contributions of indoor and outdoor sources and to measure BaP in media including indoor air, outdoor air, food and water.

PART B: A method for biological monitoring of exposure to benzo(a)pyrene, a representative polycyclic aromatic hydrocarbon (PAH), has been developed. The analytical procedure includes extraction of PAH and PAH metabolites from urine using commercial cartridges containing c …

Analysis Of C2 And C3 Hydrocarbons In Ambient Air. Section I ; Identification And Quantification Of Volatile Organics Emitted From A Landfill. Section Ii, Tsong-Sheng Chang

Theses

SECTION I

A method was developed to analyze Acetylene, Ethylene, Ethane, Propylene and Propane levels in the ambient air. Chlorinated compounds within the operation retention time, Methyl chloride, Methylene chloride and Vinyl chloride, were monitored also.

Four sampling sites are located at Carteret, Elizabeth, Newark and Montville in New Jersey. Samples were taken during the summer of 1988. Two sample duration periods utilizing 12 and 6 liter stainless steel canisters were set up to take 24 hour air samples and instantaneous air samples (5 minutes collection period).

The average levels of Acetylene, Ethylene, Ethane, Propylene and Propane at the four …

Microbial Phenol Degradation Utilizing A Complete-Mix Biological Reactor : The Effects Of Dissolved Oxygen Content, Keith Kollar

Theses

Experiments were conducted using phenol as a sole carbon source in a series of completely mixed biological reactors with solids recycle (CMBR). The reactor working volume was 4 liters, and solids were recycled from 3 liter clarifiers. Dissolved oxygen concentration (DO) was varied in order to determine the impact of this important variable on system operability.

Phenol was removed at better than 99 percent efficiency during most of the runs. Filamentous growth was not observed during any run. However, bulking did occur at higher DO levels, which was the result of microbial slime production.

A New Hazardous Waste Treatment Technology Utilizing Low Power Density Microwave Energy, Gabriele Else Windgasse

Theses

Two major applications of a new hazardous waste treatment technology using low power density microwave energy have been characterized: 1) Desorption of organic materials such as: trichloro-ethylene, para-xylene, naphthalene and gasoline hydrocarbons from substrates such as: sand and granulated activated carbon was achieved by microwave induced steam distillation and the application of a new phenomenon: arcing between GAC particles when they are exposed to microwave radiation. All contaminants could be removed to 100% (non-detectable with GC and GC-MS). 2) Decomposition of organic contaminants such as: trichloro-ethylene and trichloro-ethane in arcing/heating GAC beds. A new fluidized bed reactor ("RDW-reactor", after Ray, …

A Field Perspective On Groundwater Contamination, John A. Cherry

Maine Collection

A Field Perspective on Groundwater Contamination

Geological Society of Maine Distinguished Lecturer John Cherry, University of Waterloo, Ontario, sponsored by the Department of Geosciences, University of Southern Maine, 19th May 1988.

Contents: Lecture 1 : Contaminant Migration Processes Illustrated by Field Experiments / Lecture 2 : Behavior of Dense Non-Aqueous Phase Liquids, Illustrated by Lab Experiments and Conceptual Examples / Lecture 3 : Field Case Histories on Groundwater Contamination / Lecture 4 : Hydrogeological Concepts and Criteria for Waste Disposal / Waterloo Center for Groundwater Research Publications List

Comparative Adsorption Studies On Clay Soils, Prasanna R. Mysore

Theses

An investigation has been made to study clay as sorbent in the treatment of the hazardous contaminants of potential sludge leachate emanating from industrial landfills.

Experimentally was studied six highly toxic and hazardous chemicals, which include: phenol, aniline, cyclohexanol, cyclohexanone, cresol and monochlorophenol. Vermiculate, Kaolinite, Attacote and Hectorite clays were studied as the sorbent material. Removal of organic pollutants were measured using a total organic carbon analyzer (TOC).

Results indicate that these clays can be used for some treatment of the above mentioned organic compounds. The study shows that removal of organic pollutants by clay depends on several factors, such …

An Inventory And Condition Survey Of Rangelands In The Ashburton River Catchment, Western Australia, A A. Mitchell, A L. Payne, W F. Holman

Technical Bulletins

The inventory and condition survey of rangelands in the Ashburton River catchment, undertaken by the Department of Agriculture and Food, Western Australia (DAFWA) between 1976 and 1978, describes and maps the natural resources of the region’s pastoral leasehold land. This survey report provides a baseline record of the existence and condition of the natural area’s resources, to assist with the planning and implementation of land management practices. The report identified and described the condition of soils, landforms, vegetation, habitat, ecosystems, and declared plants and animals. It also assessed the impact of pastoralism and made land management recommendations. The area surveyed …

Reactions Of Organic N-Chloramines In The Gastric Fluid Of The Rat, Kathryn E. Mazina

Chemistry & Biochemistry Theses & Dissertations

Using chlorine as a drinking water disinfectant may have potential health effects due to its reactivity with organic amino nitrogen compounds found in the stomach. Organic N-chloramines have been shown to form in the stomachs of laboratory rats. The possible reactions of N-chloramines in the stomach fluid were examined in this study using a model radiolabeled N-chloramine. ³⁶Cl-N-Chloropiperidine, was synthesized and purified to remove ³⁶Cl-chloride. Stomach fluid was obtained from Sprague-Dawley rats which had been first fasted for 24 or 48 hours and then administered 3 mL of deionized water. Different concentrations of radiolabeled chloramine were reacted with …

Indicators Of Microbial Activity In Biological Treatment Of Hazardous Wastes, Alexander Mclean Sherrin

Theses

Three methods were used to measure the activity of mixed liquor from the Livingston, N.J. municipal wastewater treatment plant on exposure to phenol. The three methods were, substrate removal rate (SRR), dissolved oxygen uptake rate (DOUR), and the dye reduction rate (DRR). Parameters from each test were compared for reproducibility and ease of determination. The SRR test gave the most reproducible results, while the DOUR test was the least reproducible. Although the reproducibility of the DRR test was close to that of the SRR test, the DRR was more time consuming and required a greater degree of expertise and training. …

The Sunlight Effect On Trace Pollutants In Wastewater, Alan R. Sheu

Theses

In order to study the sunlight effect on the degradation rate of trace pollutants, ortho-cresol was selected to serve as a model compound in our studies. Solution of ortho-cresol alone, methylene blue alone, and the mixture of ortho-cresol and methylene blue were exposed to sunlight for more than four hours and aliquots analyzed with a spectrophotometer in order to follow the changes in absorption. Rate data were obtained for these three cases as a function of pH.

The results indicate that methylene blue does catalyze the degradation of ortho-cresol in the presence of sunlight with lower pH's affording higher reaction …

Maine Acid Rain Study : Reports, Maine Department Of Environmental Protection

Maine Collection

Maine Acid Rain Study : Reports

Maine Department of Environmental Protection, Augusta, Maine (February, 1987).

Contents: Acid Rain Precursor Inventory and Evaluation / Modeled Sulfur Deposition in Maine / High Elevation Lake Monitoring in Maine

An Inventory And Condition Survey Of Rangelands In The Carnarvon Basin, Western Australia, A L. Payne, G F. Spencer, P J. Curry

Technical Bulletins

The inventory and condition survey of rangelands in the Carnarvon Basin, undertaken by the Department of Agriculture and Food, Western Australia (DAFWA) between 1980 and 1982, describes and maps the natural resources of the region’s pastoral leasehold land. This survey report provides a baseline record of the existence and condition of the natural area’s resources, to assist with the planning and implementation of land management practices. The report identified and described the condition of soils, landforms, vegetation, habitat, ecosystems, and declared plants and animals. It also assessed the impact of pastoralism and made land management recommendations. The area surveyed covers …

Fisheries Report No 74 - Marine Resources Map Of Western Australia- Part 2 - The Influence Of Oil On Marine Resources And Associated Activities With An Emphasis On Those Found In Western Australia, H. E. Jones

Fisheries Research Reports

Part 1 of the text accompanying the marine resources maps dealt with the resources and the morphological, hydrological and meteorological characteristics of the Western Australian coastal environment. This subsidiary part is concerned with the effects of oil on marine resources and associated commercial and recreational activities.

Accounts of oil on the seas due to natural seepages appeared in Europe in the sixteenth century on the return of Spanish and Portuguese ships from voyages to the Americas. One of the earliest reports of oil pollution from a man-made source was in 1754 when leakages from wooden petroleum barges were prevalent in …

Characterization Of Microorganisims After Feeding With Phenolic Compounds : Comparing A Domestic Sludge To An Industrial Sludge, Dianne Adamowitz

Theses

This study examined the effects of phenolic compounds on the populations in mixed liquors obtained from two very different treatment plants: the Passaic Valley Sewerage Commissioners plant in Newark, and the Livingston, NJ municipal treatment plant. The dominant organisms were identified initially and after ten days exposure to phenol (100 ppm), and either 2-chlorophenol (20 ppm) or 2,6-dichlorophenol (10 ppm) in aerated batch reactors.

Results confirmed the remarkable similarity between the two mixed liquor populations, in spite of the significant differences in the operation of the two treatment plants.

Analysis Of The Charleston, Illinois Water Supply For The Presence Of Organic Mutagens Utilizing The Ames Salmonella/Microsome Assay, Steven Lee Washburn

Masters Theses

Water samples from the Charleston, Illinois water supply and selected agricultural run-off areas were tested for the presence of organic mutagenic chemicals. The Ames Salmonella/microsome mutagenicity assay utilizing strains TA98 and TA100 was used to analyze concentrated water samples. A special set of samples was exposed to the S9 activation system coupled with the TA98 strain to simulate the mammalian metabolic system.

No mutagens were detected in any of the samples tested. Several positive and negative control systems were included in the testing system. Negative control systems were used to determine the average spontaneous reversion rates for each strain for …

Microbial Characteristics Of An Industrial Mixed Liquor After Exposure To Phenolic Compounds, Patricia L. Boyle

Theses

The microbial characteristics of a mixed population from the Passaic Valley Sewerage Commissioners (PVSC) Wastewater Treatment Plant in Newark were examined. This plant handles about 250 million gallons per day of mixed sewerage, with a large industrial component. The microbial species were characterized using standard plating techniques, morphology, microscopic observation, and biochemical tests. These characteristics were determined for the fresh liquor, and after successive batch exposure to phenol (100 ppm) and 2-chlorophenol (20 ppm). Predator/prey, gram positive to gram negative bacteria ratios, and the fungi and protozoan populations were also determined. These results were compared with those previously obtained using …

The Synthesis And Evaluation Of A New Analog Of Phencyclidine (Pcp), William H. Johnson Jr.

Chemistry & Biochemistry Theses & Dissertations

Based on an interpretation of the literature of phencyclidine (PCP) together with an examination of the relevant models or prototype structures, this research has attempted to design and synthesize a rigid analog of the phencyclidine structure. The parent ring systems suggested for this study were the 1-arnino and 2-arninornethyltetralins, 10 and, 12.

Several organic compounds, based on this design, have been prepared by classical examples of reductive alkylation reactions of the corresponding 2-hydroxyciethylene-1-tetralones, 11, and by the condensation and subsequent reductive alkylation of the 1-arninotetralin, 9. These arninomethyltetralones, 28, 29 and 30, together with an example of a substituted 1-arninotetralin, …

Toxicological Studies On Aquatic Contaminants Originating From Coal Production And Utilization: The Induction Of Tolerance To Silver In Laboratory Populations Of Fish And The Chronic Toxicity Of Nickel To Fish Early Life Stages, Wesley J. Birge, Jeffrey A. Black, James F. Hobson, Albert G. Westerman

KWRRI Research Reports

Aquatic toxicity studies were performed on two important coal-derived contaminants, silver and nickel. Silver was investigated with regard to metal-induced tolerance in laboratory populations of the fathead minnow (Pimephales promelas). Fish were exposed to acute silver concentrations following acclimation to sublethal exposures of this metal. Based on median lethal times (LT50), animals which had received 14 days prior exposure to 1.5 and 15 μg Ag/L were three to four times more resistant to silver than were previously unexposed organisms. This metal-induced resistance was not a sustained response. After organisms which had been acclimated to 15 μg/L had been transferred to …

Sunlight And Plants, Some Pursuits In Physiological Ecology, Martyn M. Caldwell

Faculty Honor Lectures

A physiological ecologist, as the name suggests, focuses on the interface between plant physiology and the ecology of individual organisms. Yet, one in this field should know something about disciplines ranging from physiology, or in the case of the subject of this lecture, even photochemistry, to the study of entire ecosystems.

The Induction Of Tolerance To Heavy Metals In Natural And Laboratory Populations Of Fish, Wesley J. Birge, William H. Benson, Jeffrey A. Black

KWRRI Research Reports

Aquatic toxicity studies were performed on two natural populations of fathead minnows. One group of organisms was taken from a metal-contaminated flyash pond associated with a coal-fired power plant and the other group was collected from relatively uncontaminated hatchery ponds. Acute tests indicated that flyash pond fish were significantly more tolerant to cadmium and copper than were hatchery fish. At an exposure concentration of 6.0 mg Cd/L in moderately hard water, the median period of survival for flyash pond fish was 50.0 hr compared to 6.8 hr for hatchery fish. Both groups of organisms were about equally sensitive to zinc. …

Residual Phytotoxicity Of Mon-097 In Sludge Enriched Soils, Jennifer A. Woods

Masters Theses

Aerobically and anaerobically digested sludges were added to soil at concentrations of 0, 1, 5, and 10% (v/v). Dry weights of Avena sativa var. Noble plants, harvested 28 days after planting, were greater with increased sludge concentrations. Plant dry weights were consistently greater with aerobically than with anaerobically digested sludge. MON-097, an acetanilide herbicide, was applied to these soil/sludge mixtures at concentrations of 0, 0.5, 1, 2, 4, 8, 16 and 32 ppm. Residual phytotoxicity of MON-097 was not significantly affected by sludge concentration. These results suggest that increased concentrations of sludge in the soil do not contribute to detoxification …

The Voluntary Water Quality Monitoring Program : 1982 Project Report, Barbara Welch, Judy Potvin, Mary Ellen Dennis

Maine Collection

The Voluntary Water Quality Monitoring Program : 1982 Project Report

by Barbara Welch, Judy Potvin & Mary Ellen Dennis

Division of Environmental Evaluation and Lake Studies, Maine Department of Environmental Protection, Augusta, Maine 1982.

Contents: Understanding Maine's Lakes and Ponds / Acknowledgement / Temperature / Dissolved Oxygen / Other Measures of Lake Water Quality / Nutrients / Algae and Chlorophyll a / Transparency / Morphometry / Sampling / Protection / Classification / Answers to Most Frequently Asked Questions / Glossary of Terms / Appendix A : Maximum, Minimum, and Mean Values / Appendix B : Phosphate Content of Common Cleansers …

The Ecology Of Maine's Intertidal Habitats : A Report Prepared For The Maine State Planning Office, Peter F. Larsen, Lee F. Doggett

Maine Collection

The Ecology of Maine's Intertidal Habitats : A Report Prepared for the Maine State Planning Office

by Bigelow Laboratory for Ocean Sciences (Authors: Peter F. Larsen and Lee F. Doggett) , 1981.

Contents: Acknowledgements / List of Tables / List of Figures / Chapter 1 - Introduction / Chapter 2 - Human Impact on Intertidal Fauna / Chapter 3 - A Primer of Intertidal Ecology / Chapter 4 - A Sampler of Intertidal Species / Chapter 5 - Methodology / Chapter 6 - Results of Faunal Studies / Appendix 1 - Habitats With Date Sampled / Appendix 2 - List …

Effects Of Organic Compounds On Amphibian Reproduction, Wesley J. Birge, Jeffrey A. Black, Robert A. Kuehne

KWRRI Research Reports

Aquatic toxicity tests were conducted with atrazine, carbon tetrachloride, chloroform, methylene chloride, trisodium nitrilotriacetic acid (NTA), and phenol. Each compound was administered to developmental stages of three to five amphibian species. Exposure was initiated at fertilization and maintained through 4 days posthatching. Test responses included lethality and teratogenesis. Different amphibian species exhibited varying degrees of tolerance to the selected compounds. Greatest tolerance usually was observed for the more broadly adapted semi-aquatic and terrestrial species (e.g., Bufo americanus, Bufo fowleri). The more sensitive amphibians usually included those species which normally are restricted to aquatic or moist habitats (e.g., Rana …

Metals In Apple Cider Produced And Marketed In Connecticut, Dennis W. Hill, Thomas R. Kelley, Gale R. Morrow, Sylvia W. Matiuck

Storrs Agricultural Experiment Station

No abstract provided.