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Articles 2821 - 2850 of 3590

Full-Text Articles in Pharmacology, Toxicology and Environmental Health

Differential Role Of The Endothelium In Regulating Microvascular Blood Flow, Tao Tang May 1994

Differential Role Of The Endothelium In Regulating Microvascular Blood Flow, Tao Tang

Electronic Theses and Dissertations

The vascular endothelial cell (EC) plays an important role in regulating vascular tone and local blood flow by sensing chemical and mechanical stimuli on the vascular wall and releasing a host of vasoactive substances upon activations of endogenous or exogenous vasoactive substances. The central hypothesis is that local control of blood now and autoregulatory behavior in the microcirculation is distinctive at different levels of the vasculature and is dependent on the cellular activities of the EC and its interaction with the local environment. The in vivo as well as the ex vivo, flow-controlled preparations of the hamster cheek pouch were …


Possible Presence Of Calcium Channel Blocker(S) In Rubia Cordifolia: An Indigenous Medicinal Plant, A H. Gilani, K H. Janbaz, M Zaman, A Lateef, A Suria, H R. Ahmed Apr 1994

Possible Presence Of Calcium Channel Blocker(S) In Rubia Cordifolia: An Indigenous Medicinal Plant, A H. Gilani, K H. Janbaz, M Zaman, A Lateef, A Suria, H R. Ahmed

Department of Biological & Biomedical Sciences

Crude extract of Rubia cordifolia (RC) was tested in isolated tissue preparations for its possible calcium channel antagonistic activity. RC suppressed the spontaneous contractions of guinea-pig atria, rabbit jejunum and rat uterus in a concentration dependent manner (0.1-3 mg/ml). In rabbit aorta, it inhibited norepinephrine (10 microM) and KCl (80 mM) induced contractions. Replacement of physiological salt solution with calcium free solution abolished the spontaneous movements of rabbit jejunum. However, addition of calcium (25 micrograms/ml) in the tissue bath restored the spontaneous movements. When the tissues were pretreated with plant extract (1 mg/ml) or verapamil (0.5 microgram/ml), addition of calcium …


Hepatoprotective Effects Of Artemisia Scoparia Against Carbon Tetrachloride: An Environmental Contaminant, A H. Gilani, K H. Janbaz Mar 1994

Hepatoprotective Effects Of Artemisia Scoparia Against Carbon Tetrachloride: An Environmental Contaminant, A H. Gilani, K H. Janbaz

Department of Biological & Biomedical Sciences

The hepatoprotective activity of crude extract of artemisia scoparia (aerial parts) was investigated against experimentally produced hepatic damage using carbon tetrachloride (CCl4) as a model hepatotoxin. CCl4 at the dose of 1.5 ml/kg, produced liver damage in rats as manifested by the rise in serum levels of AST and ALT to 395 +/- 110 and 258 +/- 61 IU/l (mean +/- SEM; n = 10) respectively, compared to control values of 106 +/- 15 and 26 +/- 04. Pretreatment of rats with plant extract (150 mg/kg) significantly lowered (P < 0.01), the respective serum GOT and GPT levels to 93 +/- 05 and 27 +/- 03 IU/l, indicating hepatoprotective action. Pentobarbital sodium (75 mg/kg)-induced sleeping time in mice was found to be 140.8 +/- 1.5 min (n = 10) which was similar (P > 0.05) to that obtained in the group of animals pretreated with …


Microemulsions : A Commentary On Their Definitions, Structures And Applications(ไมโครอิมัลชัน : คำอธิบายเกี่ยวกับคำจำกัดความ, โครงสร้างและการ..., Wanchai Sutananta Jan 1994

Microemulsions : A Commentary On Their Definitions, Structures And Applications(ไมโครอิมัลชัน : คำอธิบายเกี่ยวกับคำจำกัดความ, โครงสร้างและการ..., Wanchai Sutananta

The Thai Journal of Pharmaceutical Sciences

The definitions, structures and applications of microemulsions are discussed. There are widespread believes that microemulsions are true emulsion with very small droplets of oil or water dispersed in a continuous phase. Evidence supporting these believes...


Amino Acid Composition And Contents Of Some Egyptian Plants, Fumio Ikegami, Mahmoud H., Taha I., Isamu Murakoshi Jan 1994

Amino Acid Composition And Contents Of Some Egyptian Plants, Fumio Ikegami, Mahmoud H., Taha I., Isamu Murakoshi

The Thai Journal of Pharmaceutical Sciences

The amino acid composition and contents in ethanol extracts from 18 kinds of Egyptian pi including edible seeds were investigated. Twenty eight amino acids were detected including all the esse amino acids and some plants yielded a relatively high amount ...


Optimization Of Ion-Pair High Performance Liquid Chromatography For Separation Of Endogenous Amines And Their Metabolites In Rat Brain Tissue(การหาภาวะเหมาะที่สุดสำหรับการวิเคราะห..., Rungrudee Srisawat, Anan Srikiatkhachorn, Naiphinich Kotchabhakdi, Duangdeun Meksuriyen Jan 1994

Optimization Of Ion-Pair High Performance Liquid Chromatography For Separation Of Endogenous Amines And Their Metabolites In Rat Brain Tissue(การหาภาวะเหมาะที่สุดสำหรับการวิเคราะห..., Rungrudee Srisawat, Anan Srikiatkhachorn, Naiphinich Kotchabhakdi, Duangdeun Meksuriyen

The Thai Journal of Pharmaceutical Sciences

An improved, HPLC with electrochemical detection method for the isocratic separation and simultaneous determination of endogenous amines and their metabolites from post-mortem rat brain tissue is described. Optimal conditions that maximize stability, res...


Phospholipid Microemulsions I : Determination Of Phase Diagram And Conductivity(ฟอสโฟลิปิดไมโครอิมัลชัน I : การศึกษาแผนภาพของวัตภาคและการนำไฟ..., Wanchai Sutananta Jan 1994

Phospholipid Microemulsions I : Determination Of Phase Diagram And Conductivity(ฟอสโฟลิปิดไมโครอิมัลชัน I : การศึกษาแผนภาพของวัตภาคและการนำไฟ..., Wanchai Sutananta

The Thai Journal of Pharmaceutical Sciences

Phase diagrams and conductivity of microemulsions containing soy lecithin as surfactant and butanol as cosurfactant were studied. In systems containing soybean oil, there was only one continuous large clear region in which samples had molecular solution ...


Discovery And Utilization Of Dermatological Products From Medicinal Plants In Thailand Part Ii: An Evidence For Utilization Of The Essential Oil From Anisomoles Indica, Siriporn Okonogi, Yanee Pongpaibul, Isamu Murakoshi Jan 1994

Discovery And Utilization Of Dermatological Products From Medicinal Plants In Thailand Part Ii: An Evidence For Utilization Of The Essential Oil From Anisomoles Indica, Siriporn Okonogi, Yanee Pongpaibul, Isamu Murakoshi

The Thai Journal of Pharmaceutical Sciences

The essential oil from Anisomeles indica (Labiatae) was incorporated into different types of dermatological bases. The release of essential oil from the bases showed that only some formulations were capable of releasing the active ingredient to inhibit t...


Subject Index, Author Index(ดัชนีคำสำคัญ, ดัชนีผู้แต่ง), N/A Jan 1994

Subject Index, Author Index(ดัชนีคำสำคัญ, ดัชนีผู้แต่ง), N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.


Superdisintegrants In Pharmaceutical Solid Dosage Forms And Searching For New Disintegrant(สารช่วยแตกตัวยิ่งยวดในเภสัชภัณฑ์รูปแบบฃองแฃ็ง และความพย..., Thawatchai Phaechamud, Garnpimol Ritthidej Jan 1994

Superdisintegrants In Pharmaceutical Solid Dosage Forms And Searching For New Disintegrant(สารช่วยแตกตัวยิ่งยวดในเภสัชภัณฑ์รูปแบบฃองแฃ็ง และความพย..., Thawatchai Phaechamud, Garnpimol Ritthidej

The Thai Journal of Pharmaceutical Sciences

Superdisintegrants used in pharmaceutical solid dosage forms : tablet, granule, capsule or suppository when contact with gastrointestinal fluid will effectively increase disintegration. Their mechanisms are swelling action, capillary action or deformatio...


A Constituent With Antibacterial Action From Terminalia Catappa(สารสำคัญที่มีฤทธิ์ต้านเชื้อแบคทีเรียจาก Terminalia Catappa), Siriporn Burapadaja, Pittaya Tuntiwechwuttikul, Atchima Bunchoo Jan 1994

A Constituent With Antibacterial Action From Terminalia Catappa(สารสำคัญที่มีฤทธิ์ต้านเชื้อแบคทีเรียจาก Terminalia Catappa), Siriporn Burapadaja, Pittaya Tuntiwechwuttikul, Atchima Bunchoo

The Thai Journal of Pharmaceutical Sciences

Isolation of CH2Cl2 extract obtained form the bark ofTerminalia catappa Roxb. yielded a triterpene identified as betulinic acid. The acid showed antibacterial action against a few of gram negative bacteria.(สารสกัดด้วยคลอโ...


บรรณาธิการ : การสั่งงานด้วยแผนภูมิ, ประศาสน์ เจริญพานิช Jan 1994

บรรณาธิการ : การสั่งงานด้วยแผนภูมิ, ประศาสน์ เจริญพานิช

The Thai Journal of Pharmaceutical Sciences

No abstract provided.


การใช้สารกัมมันตรังสีในงานวิจัยทางเภสัชกรรม, นภวรรณ เจนใจ, เรวดี ธรรมอุปกรณ์, อุทัย สุวรรณกฎ Jan 1994

การใช้สารกัมมันตรังสีในงานวิจัยทางเภสัชกรรม, นภวรรณ เจนใจ, เรวดี ธรรมอุปกรณ์, อุทัย สุวรรณกฎ

The Thai Journal of Pharmaceutical Sciences

No abstract provided.


สัตว์ทดลองที่ใช้ในการประเมินผลเภสัชภัณฑ์รังสี, นพวรรณ เจนใจ, เรวดี ธรรมอุปกรณ์, อุทัย สุวรรณกูฏ Jan 1994

สัตว์ทดลองที่ใช้ในการประเมินผลเภสัชภัณฑ์รังสี, นพวรรณ เจนใจ, เรวดี ธรรมอุปกรณ์, อุทัย สุวรรณกูฏ

The Thai Journal of Pharmaceutical Sciences

No abstract provided.


The Interaction Of O6-Benzylguanine And Streptozotocin In The Inactivation Of O6-Methylguanine Dna Methyltransferase And The Reversal Of 1,3 Bis (2-Chloroethyl)-1-Nitrosourea Resistance, Upendra Kumar Marathi Jan 1994

The Interaction Of O6-Benzylguanine And Streptozotocin In The Inactivation Of O6-Methylguanine Dna Methyltransferase And The Reversal Of 1,3 Bis (2-Chloroethyl)-1-Nitrosourea Resistance, Upendra Kumar Marathi

Master's Theses

No abstract provided.


Dopaminergic Modulation Of Basal Forebrain Cholinergic Neurons, Mary Elizabeth Muench Jan 1994

Dopaminergic Modulation Of Basal Forebrain Cholinergic Neurons, Mary Elizabeth Muench

Master's Theses

No abstract provided.


Role Of The Pharmacist In Support Of The Who Revised Drug Strategy(บทบาทของเภสัชกรในการสนับสนุนแผนงานด้านยาขององค์การอนามัยโลก), นิยดา เกียรติยิ่งอังศุลี Jan 1994

Role Of The Pharmacist In Support Of The Who Revised Drug Strategy(บทบาทของเภสัชกรในการสนับสนุนแผนงานด้านยาขององค์การอนามัยโลก), นิยดา เกียรติยิ่งอังศุลี

The Thai Journal of Pharmaceutical Sciences

No abstract provided.


บรรณาธิการแถลง, N/A Jan 1994

บรรณาธิการแถลง, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.


Jsps-Nrct Core University Exchange System On Pharmaceutical Sciences, Second Joint Seminar, Recent Advances On Pharmaceutics And Pharmaceutical Technology, N/A Jan 1994

Jsps-Nrct Core University Exchange System On Pharmaceutical Sciences, Second Joint Seminar, Recent Advances On Pharmaceutics And Pharmaceutical Technology, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.


Scanning Electron Micrograph And Antimicrobial Activity Of Streptomyces Species N28-1 And N97-1(ภาพอิเล็กตรอนสแคนนิงและฤทธิ์การยับยั้งจุลชีพของเชื้อ S..., Penphun Naenna, Nuttada Virochsaengaroon, Somboon Tanasupawat Jan 1994

Scanning Electron Micrograph And Antimicrobial Activity Of Streptomyces Species N28-1 And N97-1(ภาพอิเล็กตรอนสแคนนิงและฤทธิ์การยับยั้งจุลชีพของเชื้อ S..., Penphun Naenna, Nuttada Virochsaengaroon, Somboon Tanasupawat

The Thai Journal of Pharmaceutical Sciences

Two strains of Streptomyces species N28-1 and N97-1 are morphologically studied with scanning electron microscope. The antimicrobial pattern of them are determined. Strain N28-1 inhibited gram-positive bacteria, mycoplasma and mycobacteria while strain N...


ยาฉีดเภสัชภัณฑ์รังสี Tc-99m Human Serum Albumin, สง ยุตยาจาร, ศึริศักดี้ ดำรงพิศุทธิกุล, พ.ท.หญิงสุเนตรา ดำรงพิศุทธิกุล Jan 1994

ยาฉีดเภสัชภัณฑ์รังสี Tc-99m Human Serum Albumin, สง ยุตยาจาร, ศึริศักดี้ ดำรงพิศุทธิกุล, พ.ท.หญิงสุเนตรา ดำรงพิศุทธิกุล

The Thai Journal of Pharmaceutical Sciences

*ตัวหนังสือขาด


Effects Of Manufacturing Methods On Physical Properties Of Isoniazid And Diazepam Tablets(อิทธิพลของกรรมวิธีการผลิตต่อคุณสมบัติทางกายภาพของ ยาเม็..., Sirisak Dumrongpisuthigul, Song Yootyachan Jan 1994

Effects Of Manufacturing Methods On Physical Properties Of Isoniazid And Diazepam Tablets(อิทธิพลของกรรมวิธีการผลิตต่อคุณสมบัติทางกายภาพของ ยาเม็..., Sirisak Dumrongpisuthigul, Song Yootyachan

The Thai Journal of Pharmaceutical Sciences

The effects of four manufacturing methods; Direct compression, Dry granulation, Wet granulation and Microgranulation were evaluated on 7 formula of Isoniazid and Diazepam tablets. The physical properties: Weight variation Hardness, Friability, Disintegra...


Co-Sensitization Of Dopamine And Serotonin Receptors Occurs In The Absence Of A Change In The Dopamine D1 Receptor Complex After A Neonatal 6-Ohda Lesion, Li Gong Dec 1993

Co-Sensitization Of Dopamine And Serotonin Receptors Occurs In The Absence Of A Change In The Dopamine D1 Receptor Complex After A Neonatal 6-Ohda Lesion, Li Gong

Electronic Theses and Dissertations

To test whether SKF 38393 could ontogenetically sensitize dopamine (DA) D$\sb1$ receptors and whether this sensitization would be associated with biochemical changes, intact and neonatal 6-hydroxydopamine (6-OHDA)-lesioned rats (200 $\mu$g i.c.v.) were treated daily from birth with SKF 38393 (3.0 mg/kg i.p. x 28 days) or its vehicle. In DA D$\sb1$ neonatally sensitized 6-OHDA rats, enhanced locomotor responses were observed with the first SKF 38393 challenge dose (3.0 mg/kg i.p.) at 6 weeks. This response increased further with weekly SKF 38393 treatments. Enhanced stereotyped behaviors were seen in both lesioned and sensitized rats at 8 weeks. There was no change …


Variation In Powder Characteristics Of Indomethacin From Various Sources, Satit Puttipipatkhachorn, Ampol Mitrevej, Vanisara Papangkornkij, Vipa Srivichitchok Jan 1993

Variation In Powder Characteristics Of Indomethacin From Various Sources, Satit Puttipipatkhachorn, Ampol Mitrevej, Vanisara Papangkornkij, Vipa Srivichitchok

The Thai Journal of Pharmaceutical Sciences

Powder characteristics of indomethacin powder purchased from three different suppliers were studied. Moisture content, particle shape, particle size, polymorphism and particulate dissolution were determined. All of the indomethacin powder studied were of y-polymorph. This study demonstrated that particulate dissolution rate of indomethacin powder increased with decreased particle size.


Naphthoquiones And A Sterol From Impatiens Balsamina L. Root Cultures, Pharkphoom Panichayupakaranant, Hiroshi Noguchi, Wanchai De-Eknamkul, Uchio Sankawa Jan 1993

Naphthoquiones And A Sterol From Impatiens Balsamina L. Root Cultures, Pharkphoom Panichayupakaranant, Hiroshi Noguchi, Wanchai De-Eknamkul, Uchio Sankawa

The Thai Journal of Pharmaceutical Sciences

A binaphthoquinone; diphthiocol, two naphthoquinones; lawsone and 2-methoxy -1,4-naphthoquinone, and a sterol; spinasterol, were isolated from the root cultures of Impatiens balsamina . Their structures were established on the basis of UV, IR, mass, 1H NMR and 13C NMR spectral data. Diphthiocol is a new natural product in which its synthesis has been reported.


Variation In Powder Characteristics Of Indomethacin From Various Sources, Satit Puttipipatkhachorn, Ampol Mitrevej, Vanisara Papangkornkij, Vipa Srivichitchok Jan 1993

Variation In Powder Characteristics Of Indomethacin From Various Sources, Satit Puttipipatkhachorn, Ampol Mitrevej, Vanisara Papangkornkij, Vipa Srivichitchok

The Thai Journal of Pharmaceutical Sciences

Powder characteristics of indomethacin powder purchased from three different suppliers were studied. Moisture content, particle shape, particle size, polymorphism and particulate dissolution were determined. All of the indomethacin powder studied were of y-polymorph. This study demonstrated that particulate dissolution rate of indomethacin powder increased with decreased particle size.


Monolignan An Diterpene Glycosides From The Stem Of Tinsospora Rumphii Boerl., Isamu Murakoshi, Toshikazu Sekine, Hideyuki Suzuki, Chihiro Ninomiya, Kazuki Saito, Siriporn Okonogi, Fumio Ikegami Jan 1993

Monolignan An Diterpene Glycosides From The Stem Of Tinsospora Rumphii Boerl., Isamu Murakoshi, Toshikazu Sekine, Hideyuki Suzuki, Chihiro Ninomiya, Kazuki Saito, Siriporn Okonogi, Fumio Ikegami

The Thai Journal of Pharmaceutical Sciences

From dried stems of Tinospora rumphii Boerl. (Menispermaceae), a monolignan glycoside, syringin (1), and a diterpene glycoside, borapetoside B (2), were isolated. The structures of 1 and 2 were elucidated by spectroscopic and enzymatic studies. The amino acid composition and content in ethanol extract of the stems have also been studied.


ระบบยูนิตโดส : คำตอบของปัญหาการกระจายยาในโรงพยาบาล ? (Unit Dose System : The Answer To Your Problems?, อภิฤดี เหมะจุฑา Jan 1993

ระบบยูนิตโดส : คำตอบของปัญหาการกระจายยาในโรงพยาบาล ? (Unit Dose System : The Answer To Your Problems?, อภิฤดี เหมะจุฑา

The Thai Journal of Pharmaceutical Sciences

No abstract provided.


Monolignan An Diterpene Glycosides From The Stem Of Tinsospora Rumphii Boerl., Isamu Murakoshi, Toshikazu Sekine, Hideyuki Suzuki, Chihiro Ninomiya, Kazuki Saito, Siriporn Okonogi, Fumio Ikegami Jan 1993

Monolignan An Diterpene Glycosides From The Stem Of Tinsospora Rumphii Boerl., Isamu Murakoshi, Toshikazu Sekine, Hideyuki Suzuki, Chihiro Ninomiya, Kazuki Saito, Siriporn Okonogi, Fumio Ikegami

The Thai Journal of Pharmaceutical Sciences

From dried stems of Tinospora rumphii Boerl. (Menispermaceae), a monolignan glycoside, syringin (1), and a diterpene glycoside, borapetoside B (2), were isolated. The structures of 1 and 2 were elucidated by spectroscopic and enzymatic studies. The amino acid composition and content in ethanol extract of the stems have also been studied.


Biosynthesis In Vitro Of Some Neurotoxic Amino Acids In Lathyrus Species, Fumio Ikegami, Yu-Haey Kuo, Fernand Lambein, Isamu Murakoshi Jan 1993

Biosynthesis In Vitro Of Some Neurotoxic Amino Acids In Lathyrus Species, Fumio Ikegami, Yu-Haey Kuo, Fernand Lambein, Isamu Murakoshi

The Thai Journal of Pharmaceutical Sciences

Two different forms of cysteine synthase (CSase) were purified from the grass pea (Lathyrus sativus), being separated by chromatography on DEAE-Sepharose Fast Flow or EAH-Sepharose 4B. Data on the substrate specificity show that both isoenzymes catalyse ...