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Articles 2761 - 2790 of 3590

Full-Text Articles in Pharmacology, Toxicology and Environmental Health

Subacute Toxicity Of Traditional Medicinal Benjakul(พิษกึ่งเฉียบพลันของยาแผนโบราณเบญจกูล), Pranee Chavalittumrong, Aimmanas Attawish, Pat Rugsamon, Pranee Chuntapet Jan 1996

Subacute Toxicity Of Traditional Medicinal Benjakul(พิษกึ่งเฉียบพลันของยาแผนโบราณเบญจกูล), Pranee Chavalittumrong, Aimmanas Attawish, Pat Rugsamon, Pranee Chuntapet

The Thai Journal of Pharmaceutical Sciences

Benjakul, a Thai traditional medicine, is composed of five constituents, namely Zingiber officinale rhizomes, Piper retrofractum fruits, Plumbago indica root, Piper sarmentosum and Piper sp. locally called Sa-Karn, at different ratios on traditional exam...


Constituents Of Artocarpus Gomezianus Leaves, Benjaporn Kingroungpet, Thatree Phadungcharoen, Nijsiri Ruangrungsi, Toshikazu Sekine Jan 1996

Constituents Of Artocarpus Gomezianus Leaves, Benjaporn Kingroungpet, Thatree Phadungcharoen, Nijsiri Ruangrungsi, Toshikazu Sekine

The Thai Journal of Pharmaceutical Sciences

Examination of the ethanol extract from the leaves of Artocarpus gomezianus (Moraceae) revealed the presence of a long chain hydrocarbon, 1-dotriacontanol, a steroid; (3-sitosterol, two triterpenoids; lupeol-3-acetate and simiarenol, and phenolic glycosi...


Production Technique And Pharmaceutical Application Of Microspheres.Part Ii. Other Production Techniques / Comparion And Application(เทคนิคการผลิตไมโครสเฟียร์และการประยุกต์ท..., ธวัชชัย แพชมัด, กาญจน์พิมล ฤทธิเดช Jan 1996

Production Technique And Pharmaceutical Application Of Microspheres.Part Ii. Other Production Techniques / Comparion And Application(เทคนิคการผลิตไมโครสเฟียร์และการประยุกต์ท..., ธวัชชัย แพชมัด, กาญจน์พิมล ฤทธิเดช

The Thai Journal of Pharmaceutical Sciences

Microsphere can also be prepared by other techniques: chemical and thermal crosslinking, spray drying, meltable dispersion, polymerization and coacervation. Advantage and disadvantage of each preparation technique are compared. The appearance and morphol...


Comparative Quality Investigation Of Three Locally-Manufactured Medicines In Thailand(การเปรียบเทียบคุณภาพยาสามชนิดที่ผลิตขี้นในประเทศไทย), Jinda Wangboonskul, Voravich Kitiwongsoonthorn, Sumon Sakolchai, Chanchai Charupash, Kanokwan Jarukumjorn, Supawadee Chieawchanwatana, Natthida Weerapreeyakul, Wirat Ruengsitagoon, Unchalee Tattawasart Jan 1996

Comparative Quality Investigation Of Three Locally-Manufactured Medicines In Thailand(การเปรียบเทียบคุณภาพยาสามชนิดที่ผลิตขี้นในประเทศไทย), Jinda Wangboonskul, Voravich Kitiwongsoonthorn, Sumon Sakolchai, Chanchai Charupash, Kanokwan Jarukumjorn, Supawadee Chieawchanwatana, Natthida Weerapreeyakul, Wirat Ruengsitagoon, Unchalee Tattawasart

The Thai Journal of Pharmaceutical Sciences

Locally-manufactured medicines of 3 selected drugs have been investigated for their pharmaceutical quality and comparison has been made between GMP-approved and non-GMP approved factories. In this study, aluminium hydroxide suspension, ampicillin capsule...


Food Additive - Drug Interaction Induced Mutagens And Possible Prevention(การเกิดสารก่อกลายพันธุ์จากอันตรกิริยาระหว่างสารเจือปน ในอาหา..., Kaew Kansadalampai, Suyanee Suharitdamrong Jan 1996

Food Additive - Drug Interaction Induced Mutagens And Possible Prevention(การเกิดสารก่อกลายพันธุ์จากอันตรกิริยาระหว่างสารเจือปน ในอาหา..., Kaew Kansadalampai, Suyanee Suharitdamrong

The Thai Journal of Pharmaceutical Sciences

Twenty-seven of drug preparations were treated with sodium nitrite and the products were tested for mutagenicity on Salmonella typhimurium test system (Ames test). Using Ames spot test, it was suggested that eleven preparations were mutagenic; then, they...


นิพนธ์ปฏิทัคน์: บทบาทของเพศต่อการศึกษาทางเภสัชจลนศาสตร์ และเภสัชพลศาสตร์, ศรีสมบัติ นวนพรัตน์สกุล Jan 1996

นิพนธ์ปฏิทัคน์: บทบาทของเพศต่อการศึกษาทางเภสัชจลนศาสตร์ และเภสัชพลศาสตร์, ศรีสมบัติ นวนพรัตน์สกุล

The Thai Journal of Pharmaceutical Sciences

No abstract provided.


Application Of Freeze-Drying Technique In Preparing Indomethacin-Lactose Solid Dispersion(การใช้เทคนิคการทำให้แห้งแบบเยือกแข็งในการเตรียม อินโดเม..., Pienkit Dangprasirt, Sansanee Pongwai, Wasan Limpongsanurak, Chockchai Tregitwatana Jan 1996

Application Of Freeze-Drying Technique In Preparing Indomethacin-Lactose Solid Dispersion(การใช้เทคนิคการทำให้แห้งแบบเยือกแข็งในการเตรียม อินโดเม..., Pienkit Dangprasirt, Sansanee Pongwai, Wasan Limpongsanurak, Chockchai Tregitwatana

The Thai Journal of Pharmaceutical Sciences

Indomethacin (ID) solid dispersions were prepared by coprecipitation method using lactose as a water-soluble carrier. Two techniques, simple evaporation and freeze-drying techniques, were used to prepare 1:1 and 1:5 indomethacindactose coprecipitates. Di...


Study Of Antiemetic Activity Of Morinda Citrifolia L. Fruits(การศึกษาฤทธิ์ต้านอาเจียนของผลยอ), Anchalee Chuthaputti, Puntarika Na, Uraiwan Permpipat, Yenchit Techadamrongsin Jan 1996

Study Of Antiemetic Activity Of Morinda Citrifolia L. Fruits(การศึกษาฤทธิ์ต้านอาเจียนของผลยอ), Anchalee Chuthaputti, Puntarika Na, Uraiwan Permpipat, Yenchit Techadamrongsin

The Thai Journal of Pharmaceutical Sciences

Morinda citrifolia L. or ‘ Yor’ is one of sixty six medicinal plants selected for the primary health care in Thailand. According to Thai traditional medicine, infusion or decoction of roasted or grilled mature, unripe fruits has been used to relieve ...


บทความพิเศษ แนวคิดปัจจุบันเรื่องการ,ประเมินความเสี่ยงจากพิษ ของสารเกาะเกี่ยว (Bound Residues) ในอา..., อรรัตน์ สมาธิวัฒน์, พาลาภ สิงหเสนี Jan 1996

บทความพิเศษ แนวคิดปัจจุบันเรื่องการ,ประเมินความเสี่ยงจากพิษ ของสารเกาะเกี่ยว (Bound Residues) ในอา..., อรรัตน์ สมาธิวัฒน์, พาลาภ สิงหเสนี

The Thai Journal of Pharmaceutical Sciences

No abstract provided.


Effect Of Clinacanthus Nutans On Human Cell-Mediated Immune Response In Vitro(การศึกษาฤทธิ์ของสารสกัดจากพญายอต่อการตอบสนอง ทางภูมิคุ้มกัน..., Busarawan Sriwanthana, Pranee Chavalittumrong, Laor Chompuk Jan 1996

Effect Of Clinacanthus Nutans On Human Cell-Mediated Immune Response In Vitro(การศึกษาฤทธิ์ของสารสกัดจากพญายอต่อการตอบสนอง ทางภูมิคุ้มกัน..., Busarawan Sriwanthana, Pranee Chavalittumrong, Laor Chompuk

The Thai Journal of Pharmaceutical Sciences

The extract of Clinacanthus nutans has been used for the treatment against a variety of symptoms from either infectious or non-infectious agents. Less has been known for its activity on the immune system. Human immunocompetent cells were used to study th...


Key Words Index, Authors Index(ดรรชนีกุญแจคำ, ดรรชนีผู้แต่ง), N/A Jan 1996

Key Words Index, Authors Index(ดรรชนีกุญแจคำ, ดรรชนีผู้แต่ง), N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.


Relationships Between The Expression Of Genes Involved In The Regulation Of Apoptosis And Cell Death Induced By Nitrogen Mustard In Human Colon Carcinoma Cell Lines, Greggory Bernard Herbert Jan 1996

Relationships Between The Expression Of Genes Involved In The Regulation Of Apoptosis And Cell Death Induced By Nitrogen Mustard In Human Colon Carcinoma Cell Lines, Greggory Bernard Herbert

Dissertations

No abstract provided.


Pharmacologic Studies On Synthetic Analogues Of Heparin With Selective Affinity To Endogenous Serine Protease Inhibitors, Walter P. Jeske Jan 1996

Pharmacologic Studies On Synthetic Analogues Of Heparin With Selective Affinity To Endogenous Serine Protease Inhibitors, Walter P. Jeske

Dissertations

No abstract provided.


Development Of Skin Stripping Technique To Evaluate In Vivo Percutaneous Absorption Of Diclofenac. Ii. Correlation With In Vitro Drug Release And Application To Topical Bioavailability Determination, Parkpoom Tengamnuay, Wanthanee Samitamarn Jan 1996

Development Of Skin Stripping Technique To Evaluate In Vivo Percutaneous Absorption Of Diclofenac. Ii. Correlation With In Vitro Drug Release And Application To Topical Bioavailability Determination, Parkpoom Tengamnuay, Wanthanee Samitamarn

The Thai Journal of Pharmaceutical Sciences

A skin stripping procedure to evaluate the in vivo percutaneous absorption of diclofenac diethylammonium gels was developed as a possible alternative to the conventional method of measuring plasma drug concentrations. Eight subjects participated in a fou...


Editorial: Cqi And How It Involves Pharmacy, Supakit Wongwiwatthananukit, Pharm. D. Jan 1996

Editorial: Cqi And How It Involves Pharmacy, Supakit Wongwiwatthananukit, Pharm. D.

The Thai Journal of Pharmaceutical Sciences

No abstract provided.


Development Of Indicators For Investigating Drug Use In Drugstores(การพัฒนาคำบ่งชี้สภาพการใช้ยาในร้านยา), Sathitpong Thanaviriyakul, Sauwakon Ratanawijitrasin, Yupadee Sirisinsuk, Wanna Sriwiriyanupap Jan 1996

Development Of Indicators For Investigating Drug Use In Drugstores(การพัฒนาคำบ่งชี้สภาพการใช้ยาในร้านยา), Sathitpong Thanaviriyakul, Sauwakon Ratanawijitrasin, Yupadee Sirisinsuk, Wanna Sriwiriyanupap

The Thai Journal of Pharmaceutical Sciences

The main objective of this study was to develop and assess the utility of a set of indicators for capturing drug use behavior in community pharmacy setting. Thirty-six indicators were developed by a group of experts. These indicators were intended to add...


บทบรรณาธิการ : อันตรายจากชื่อยาสับสน, นิยดา เกียรติยิ่งอังศุลี Jan 1996

บทบรรณาธิการ : อันตรายจากชื่อยาสับสน, นิยดา เกียรติยิ่งอังศุลี

The Thai Journal of Pharmaceutical Sciences

การใช้ยาที่สมเหตุสมผล มีปัจจัยที่เกี่ยวข้องมากมาย การใช้ยาที่ไม่ถูกต้องบางครั้งเกิดจาก...


Toxicity Of Traditional Medicine Trisan. Part 2. Vata And Semha Formulas(พิษของยาแผนโบราณตรีสาร ตอนที่ 2 ตำรับวาตะและเสมหะสมุฏฐาน), Pranee Chavalittumrong, Aimmanas Attawish, Pat Rugsamon, Pranee Chuntapet Jan 1996

Toxicity Of Traditional Medicine Trisan. Part 2. Vata And Semha Formulas(พิษของยาแผนโบราณตรีสาร ตอนที่ 2 ตำรับวาตะและเสมหะสมุฏฐาน), Pranee Chavalittumrong, Aimmanas Attawish, Pat Rugsamon, Pranee Chuntapet

The Thai Journal of Pharmaceutical Sciences

Trisan, a Thai traditional medicine, is composed of three constituents, namely Plumbago indica, Piper sarmentosum and Piper sp. locally called Sa-Karn, at different ratios based on traditional diagnosis of patients. Vata formula of Trisan, used for the e...


Production Techniques And Pharmaceutical Application Of Microspheres. Part 1. Emulsification/Solvent Evaporation Technique(เทคนิคการผลิตไมโครสเฟียร์และการประยุกต์ทางเ..., Thawatchai Phaechamud, Garnpimol C Jan 1996

Production Techniques And Pharmaceutical Application Of Microspheres. Part 1. Emulsification/Solvent Evaporation Technique(เทคนิคการผลิตไมโครสเฟียร์และการประยุกต์ทางเ..., Thawatchai Phaechamud, Garnpimol C

The Thai Journal of Pharmaceutical Sciences

The purposes of the preparation of pharmaceutical microspheres are to control drug release, to stabilize and to mask color and taste of drug. Various production techniques can be used such as emul- sification/solvent evaporation, chemical and thermal cro...


Effect Of Endotoxin On Blood Rheology(ผลของเอ็นโดท็อกชินต่อการไหลของเลือด), เพ็ซรินทร์ ยามะรัต Jan 1996

Effect Of Endotoxin On Blood Rheology(ผลของเอ็นโดท็อกชินต่อการไหลของเลือด), เพ็ซรินทร์ ยามะรัต

The Thai Journal of Pharmaceutical Sciences

There were changes in the rheological properties of blood from patients with Plasmodium falciparum such as an increase in blood viscosity and a decrease in RBC deformability. The mechanism of these changes was not clearly understood. However, there was e...


Semisolid Matrix Capsule Formulations(ตำรับแคปซูลเมตริกซ์กึ่งแข็ง), Wanchai Sutananta, Theerasak Rojanarata Jan 1996

Semisolid Matrix Capsule Formulations(ตำรับแคปซูลเมตริกซ์กึ่งแข็ง), Wanchai Sutananta, Theerasak Rojanarata

The Thai Journal of Pharmaceutical Sciences

Semisolid matrix capsule is a capsule in which a hard gelatin capsule is filled with liquified mixture instead of powder drug or granules. The mixture then becomes harder and sits inside the capsule shell. The advantages of the dose form include; the sui...


Determination Of Colchicine In Gloriosa Superba L. By Enzyme-Linked Immunosorbent Assay(การวิเคราะห์หาปริมาณ, Colchicine ในดองดึง(Gloriosa Superba L.) โดยวิธี Enzyme - Linked Immunosor..., Vimolmas Lipipun, Wanchai De-Eknamkul, Malai Luempol Jan 1996

Determination Of Colchicine In Gloriosa Superba L. By Enzyme-Linked Immunosorbent Assay(การวิเคราะห์หาปริมาณ, Colchicine ในดองดึง(Gloriosa Superba L.) โดยวิธี Enzyme - Linked Immunosor..., Vimolmas Lipipun, Wanchai De-Eknamkul, Malai Luempol

The Thai Journal of Pharmaceutical Sciences

An enzyme-linked immunosorbent assay (ELISA) was developed for the determination of colchicine, the active constituent in Gloriosa superba. The measuring range of the assay was from 10 to 105 ng/ml of colchicine. The developed ELISA was highly sensitive ...


Preparation Of Indomethacin Solid Dispersion Tablets Using Lactose And Polyvinylpyrrolidone As Single And Combined Water-Soluble Carriers(การเตรียมยาเม็ดอินโดเมธาชินโซลิดดิสเพอ..., Pienkit Dangprasirt, Sansanee Pongwai, Prawalwan Sitthitrai, Withaya Aloondacharchai Jan 1996

Preparation Of Indomethacin Solid Dispersion Tablets Using Lactose And Polyvinylpyrrolidone As Single And Combined Water-Soluble Carriers(การเตรียมยาเม็ดอินโดเมธาชินโซลิดดิสเพอ..., Pienkit Dangprasirt, Sansanee Pongwai, Prawalwan Sitthitrai, Withaya Aloondacharchai

The Thai Journal of Pharmaceutical Sciences

Indomethacin solid dispersions were prepared by coprécipitation method using lactose and polyvinylpyrrolidone (PVP K30) as single and combined water-soluble carriers. The prepared coprecipitates were incorporated into tablets by direct compression proce...


Development Of Skin Stripping Technique To Evaluate In Vivo Percutaneous Absorption Of Diclofenac. I. Effects Of Skin Stripping Sequence, Occlusion Time, And Sites Of Application, Parkpoom Tengamnuay, Wanthanee Samitamarn, Uthai Suvanakoot Jan 1996

Development Of Skin Stripping Technique To Evaluate In Vivo Percutaneous Absorption Of Diclofenac. I. Effects Of Skin Stripping Sequence, Occlusion Time, And Sites Of Application, Parkpoom Tengamnuay, Wanthanee Samitamarn, Uthai Suvanakoot

The Thai Journal of Pharmaceutical Sciences

Several methods are available for the evaluation of percutaneous absorption of topical drug formulations. The most commonly used in vivo methods are the determination of drug level in plasma and measurements of pharmacological and/or therapeutic response...


Phase Ia/Ib Trial Of Anti-Gd2 Chimeric Monoclonal Antibody 14.18 (Ch L4.18) And Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (Rhgm-Csf) In Metastatic Melanoma, James Murray, Eugenie Kleinerman, Shu-Fang Jia, Michael Rosenblum, Omar Eton, Antonio Buzaid, Sewa Legha, Merrick Ross, Lora Thompson, Mansoor Saleh Jan 1996

Phase Ia/Ib Trial Of Anti-Gd2 Chimeric Monoclonal Antibody 14.18 (Ch L4.18) And Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (Rhgm-Csf) In Metastatic Melanoma, James Murray, Eugenie Kleinerman, Shu-Fang Jia, Michael Rosenblum, Omar Eton, Antonio Buzaid, Sewa Legha, Merrick Ross, Lora Thompson, Mansoor Saleh

Haematology and Oncology, East Africa

We performed a phase Ia/Ib trial of chimeric anti-GD2 monoclonal antibody 14.18 (ch14.18) in combination with recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) to determine the maximum tolerated dose as well as immunologic and biologic responses to the regimen. Sixteen patients with metastatic malignant melanoma received escalating doses of ch14.18 (15-60 mg/m2) administered intravenously for 4 h on day 1. Twenty-four hours later, subcutaneous injections of rhGM-CSF were administered daily for a total of 14 days. Significant side effects were related to ch14.18 infusion and consisted of moderate to severe abdominal and/or extremity pain, blood pressure changes, headache, nausea, diarrhea, peripheral …


Characterization Of Central Serotonergic Alterations In Male Rats Following Prenatal Exposure To Fluoxetine, Theresa M. Cabrera Jan 1996

Characterization Of Central Serotonergic Alterations In Male Rats Following Prenatal Exposure To Fluoxetine, Theresa M. Cabrera

Dissertations

No abstract provided.


Comparative Pharmacologic Studies On Synthetic And Recombinant Inhibitors Of Thrombin, Demetra D. Callas Jan 1996

Comparative Pharmacologic Studies On Synthetic And Recombinant Inhibitors Of Thrombin, Demetra D. Callas

Dissertations

No abstract provided.


An Update On Hyperlipidemia And Its Management, R A. Memon, A H. Gilani Oct 1995

An Update On Hyperlipidemia And Its Management, R A. Memon, A H. Gilani

Department of Biological & Biomedical Sciences

No abstract provided.


Maturational Changes In Cerebrovascular Ca2+ In Hypoxia, Shelley D. Zurcher Jun 1995

Maturational Changes In Cerebrovascular Ca2+ In Hypoxia, Shelley D. Zurcher

Loma Linda University Electronic Theses, Dissertations & Projects

The clinical consequences of hypoxic cerebrovascular insults in the neonate, can be severe. It would therefore be valuable to understand the mechanisms of hypoxia-induced cerebrovasodilation. These studies were done in ovine middle cerebral and common carotid arteries to help elucidate the mechanisms through which calcium handling is involved in hypoxic cerebral vasodilation, comparing newborns and adults. The present studies demonstrate that calcium sensitivity (measured by the pD2) and the maximum contractile response to calcium increased with maturation. In addition, hypoxia depressed the maximum response to calcium and this effect was greater in adult than in newborn arteries. These results suggest …


Persistent Oral Dyskinesias Induced By Long-Term Haloperidol Treatment Is Dissociated From Changes In Neostriatal B(Max) And Mrna Content For Dopamine D(2) Receptors, Nuoyu Huang May 1995

Persistent Oral Dyskinesias Induced By Long-Term Haloperidol Treatment Is Dissociated From Changes In Neostriatal B(Max) And Mrna Content For Dopamine D(2) Receptors, Nuoyu Huang

Electronic Theses and Dissertations

Due to the presumed associations of dopamine (DA) receptor supersensitivity phenomena in both long-term neuroleptic-treated tardive dyskinetic rats and neonatal 6-hydroxydopamine (n6-OHDA)-lesioned rats, we studied the influence of haloperidol on n6-OHDA-lesioned rats. At 3 days after birth rats received 6-OHDA-HBr (200 $\mu$g, bilateral intracerebroventricularly; desipramine pretreatment, 20 mg/kg, 1h) or vehicle. Two months later haloperidol (1.5/kg/day $\times$ 2 days/week for 4 weeks, then 1.5 mg/kg/day, every day for 10 months) was added to the drinking water. Spontaneous oral activity of intact and n6-OHDA-lesioned rats receiving haloperidol was reached and maintained at significantly higher levels after 15 weeks of haloperidol treatment. …