Neuroscience and Neurobiology Commons^™

Diminished Nicotine Withdrawal In Adolescent Rats: Implications For Vulnerability To Addiction, Laura O'Dell

Departmental Papers (Psych)

No abstract provided.

The Effect Of Tgf-B And Egf On Mmp-2 Activation And Mt1-Mmp Phosphorylation In U87mg And T98g Human Glioma Cells, Jacquelyn B. Knupp

Honors Theses

Glioblastoma multiforme (GBM), a high-grade, malignant brain tumor of astrocyte origin, invades normal brain tissue and most often results in death ofthe patient withinayearofdiagnosis. In order to invade the surrounding tissue and thereby metastasize, these tumor cells must migrate through the extracellular matrix. The pmpose ofthis research project is to investigate the family ofmatrix metalloproteinases responsible for extracellular degradation. Specifically, this investigation looks at MMP-2 activation via MT 1-MMP and the possible importance of phosphorylation of the tyrosine residue on the cytoplasmic tail of MTl-MMP. U87wildtypegliomacellsaswellasT98 p53 mutant glioma cells were treated with transforming growth factor beta (TGF-P). Preliminary results …

Epipregnanolone And A Novel Synthetic Neuroactive Steroid Reduce Reduce Alcohol Self-Administration In Rats., Laura O'Dell

Selected Works Temporary Series

No abstract provided.

Stress Enhancement Of Craving During Sobriety: A Risk For Relapse, Laura O'Dell

Selected Works Temporary Series

No abstract provided.

Stress Enhancement Of Craving During Sobriety: A Risk For Relapse, Laura O'Dell

Departmental Papers (Psych)

No abstract provided.

Epipregnanolone And A Novel Synthetic Neuroactive Steroid Reduce Reduce Alcohol Self-Administration In Rats., Laura O'Dell

Departmental Papers (Psych)

No abstract provided.

Lateral Hypothalamic Signaling Mechanisms Underlying Feeding Stimulation: Differential Contributions Of Src Family Tyrosine Kinases To Feeding Triggered Either By Nmda Injection Or By Food Deprivation, Arshad Khan, Herman Cheung, Elizabeth Gillard, Jennifer Palarca, Derek Welsbie, James Gurd, B. Stanley

Selected Works Temporary Series

No abstract provided.

Lateral Hypothalamic Signaling Mechanisms Underlying Feeding Stimulation: Differential Contributions Of Src Family Tyrosine Kinases To Feeding Triggered Either By Nmda Injection Or By Food Deprivation, Khan, Herman Cheung, Elizabeth Gillard, Jennifer Palarca, Derek Welsbie, James Gurd, B. Stanley

Departmental Papers (Biology)

No abstract provided.

Intravenous 2-Deoxy-D-Glucose Injection Rapidly Elevates Levels Of The Phosphorylated Forms Of P44/42 Mitogen-Activated Protein Kinases (Extracellularly Regulated Kinases 1/2) In Rat Hypothalamic Parvicellular Paraventricular Neurons, Arshad Khan, Alan Watts

Selected Works Temporary Series

No abstract provided.

Enhanced Operant Self-Administration Of Alcohol In Wistar Rats Receiving Intermittent Versus Continuous Alcohol Vapor Exposure, Laura O'Dell

Selected Works Temporary Series

No abstract provided.

Ethanol-Induced Increases In Neuroactive Steroids In The Rat Brain And Plasma Are Absent In Adrenalectomized And Gonadectomized Rats, Laura O'Dell

Selected Works Temporary Series

No abstract provided.

Nicotine Withdrawal In Adolescent And Adult Rats, Laura O'Dell

Selected Works Temporary Series

No abstract provided.

Serotonin1b Receptors In The Ventral Tegmental Area Modulate Cocaine-Induced Elevations Of Dopamine Release In The Nucleus Accumbens, Laura O'Dell

Selected Works Temporary Series

No abstract provided.

Neurobiological Mechanisms In The Transition From Drug Use To Drug Dependence, Laura O'Dell

Selected Works Temporary Series

No abstract provided.

Changes In Gdnf Protein Content Of Skeletal Muscle Following Involuntary Exercise Are Long Lived, Kyle R. Kinnell, Monica J. Czarnopys, John Spitsbergen

Biological Sciences Faculty and Graduate Student Research

Glial-cell line derived neurotrophic factor (GDNF) is a neurotrophic factor produced by skeletal muscle. GDNF has been shown to be potent survival factor for motor neurons. We have previously shown that GDNF content in skeletal muscle is altered following exercise and GDNF levels 24 hours after the last bout of exercise are significantly different than those measured immediately after exercise. We sought to determine how long after exercise do GDNF protein levels remain altered. We removed extensor digitorum longus (EDL) and Soleus (SOL), 24 hr, 72 hr and 1 week following the last bout of involuntary exercise. Muscles were processed …

Ethanol-Induced Increases In Neuroactive Steroids In The Rat Brain And Plasma Are Absent In Adrenalectomized And Gonadectomized Rats, Laura O'Dell

Departmental Papers (Psych)

No abstract provided.

Nicotine Withdrawal In Adolescent And Adult Rats, Laura O'Dell

Departmental Papers (Psych)

No abstract provided.

Serotonin1b Receptors In The Ventral Tegmental Area Modulate Cocaine-Induced Elevations Of Dopamine Release In The Nucleus Accumbens, Laura O'Dell

Departmental Papers (Psych)

No abstract provided.

Intravenous 2-Deoxy-D-Glucose Injection Rapidly Elevates Levels Of The Phosphorylated Forms Of P44/42 Mitogen-Activated Protein Kinases (Extracellularly Regulated Kinases 1/2) In Rat Hypothalamic Parvicellular Paraventricular Neurons, Khan, Alan Watts

Departmental Papers (Biology)

No abstract provided.

Neurobiological Mechanisms In The Transition From Drug Use To Drug Dependence, Laura O'Dell

Departmental Papers (Psych)

No abstract provided.

Exposure Of Nervous System Cells To Polychlorinated Biphenyls (Pcbs) Results In Significant Alterations In Levels Of Expression Of Neurotrophic Factors, Charles F. Ide, Jay C. Means, Trisha M. Basford, John Spitsbergen

Biological Sciences Faculty and Graduate Student Research

Toxic insult by PCBs results in learning and memory deficits in humans. Alterations in expression of neurotrophic factors and/or their receptors have been linked to changes in cognition. How PCBs affect cognition is not known. We propose that PCBs affect cognition by altering neurotrophic factor expression or effects. We exposed cultured C6 glial cells in medium containing PCB (Aroclor 1254 (10ppm)). Control cells were treated with DMSO or regular medium. Cells were incubated at 37o C for up to 72 hours. Medium samples were taken at 6hr, 24hr, 48hr, and 72hr intervals. Enzyme-linked immunosorbent assays (ELISA) were used to determine …

Acutely-Administered Ethanol Participates In Testosterone Synthesis And Increases Testosterone In The Rat Brain., Laura O'Dell

Selected Works Temporary Series

No abstract provided.

Acutely-Administered Ethanol Participates In Testosterone Synthesis And Increases Testosterone In The Rat Brain., Laura O'Dell

Departmental Papers (Psych)

No abstract provided.

Cell Biology Of Apoe In Cortical Cultured Neurons: Possible Roles In Alzheimer's Disease, Anna G. Barsukova

Masters Theses

The apolipoprotein E4 (apoE4) genotype is a major risk factor for Alzheimer's disease (AD). Previous studies have shown that apoE4 is less effective than apoE3 in supporting neurite outgrowth in adult mice cortical cultures. However the mechanism underlying this phenomenon is not known. To understand this mechanism and the broader role of apoE isoforms on neuronal biology I examined the rate of apoE isoforms internalization in neurons, effects of apoE isoforms on lipid uptake by neurons, effects of apoE isoforms on neuronal environment - microglia and on neuroregeneration, or neurogenesis.

I examined the binding and internalization of recombinant human apoE3 …

Enhanced Locomotor, Reinforcing, And Neurochemical Effects Of Cocaine In Serotonin 5-Hydroxytryptamine 2c Receptor Mutant Mice, Laura O'Dell

Selected Works Temporary Series

No abstract provided.

Enhanced Locomotor, Reinforcing, And Neurochemical Effects Of Cocaine In Serotonin 5-Hydroxytryptamine 2c Receptor Mutant Mice, Laura O'Dell

Departmental Papers (Psych)

No abstract provided.

Domain-Specific Olivocerebellar Projection Regulated By The Epha-Ephrin-A Interaction, Kazuhiko Nishida, John Flanagan, Masaru Nakamoto

Biology Faculty Publications

Neural maps in the vertebrate central nervous system often show discontinuously segregated, domain-to-domain patterns. However, the molecular mechanism that establishes such maps is not well understood. Here we show that in the chicken olivocerebellar system, EphA receptors and ephrin-As are expressed with distinct levels and combinations in mapping domains. When ephrin-A2 is retrovirally overexpressed in the cerebellum, the olivocerebellar map is disrupted, excluding axons with high receptor activity from ectopic expression domains. Conversely, overexpression of a truncated EphA3 receptor in the cerebellum reduces endogenous ligand activity to undetectable levels and causes aberrant mapping, with high receptor axons invading high ligand …

Effects Of Apolipoprotein E On Olfactory Nerve Plasticity In Mice, Jody L. Short

Masters Theses

No abstract provided.

Regional Specific Brain Apoe Modulation By The Estrous Cycle And Exogenous Estrogen, Emily Rosario

Masters Theses

Previous studies have demonstrated that 17β-estradiol can modify apolipoprotein E (apoE) expression. I found that apoE protein varied as a function of the estrous cycle and 17β-estradiol (E2) in a region specific manner in the mouse brain. I also found that apoE concentration was lowest on estrus in the hippocampus, cingulate cortex and frontal cortex; apoE concentration was highest on estrus in the olfactory bulb and cerebellum. No changes in apoE were found in the striatum throughout the estrous cycle. Exogenous E2 significantly raised tissue levels in the olfactory bulb and cerebellum, but did not increase apoE in cortical samples …

Effects Of E2 On Apoe Secretion And Neurite Outgrowth In Cultured Adult Mouse Cortical Neurons, Fei Shen

Masters Theses

Estrogen replacement therapy appears to delay the onset of Alzheimer's disease (AD). The mechanism whereby estrogen prevents the pathogenesis of AD is unknown. In the present study, I examined the effects of 17-β-estradiol (E2) on neurite outgrowth from adult mice cortical neurons (AMC) in culture. I found that E2 increases apoE secretion and neurite outgrowth in AMC neurons from wild type mice in a dose dependent fashion. The neurite outgrowth promoting effect of E2 was not observed in AMC neurons derived from age-, sex-, and stain-matched apoE deficient/apoE gene knockout (apoE KO) mice. Furthermore, E2 has isoform specific effects on …