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Articles 211 - 240 of 474

Full-Text Articles in Microbiology

Bax Over-Expression Coupled With Bcl-2 Suppression Under The Control Of The Cancer-Specific Thymidine Kinase Promoter, Brian H. Ladle, Dr. Kim L. O'Neill Jan 2014

Bax Over-Expression Coupled With Bcl-2 Suppression Under The Control Of The Cancer-Specific Thymidine Kinase Promoter, Brian H. Ladle, Dr. Kim L. O'Neill

Journal of Undergraduate Research

As researchers continue to discover the molecular origins of cancer, gene therapy targeting cellular processes gone awry shows great promise as the future in cancer treatment. Extensive research is being done to develop more effective techniques targeting different cellular events. One pathway receiving increased attention is apoptosis (the default mechanisms activated intracellularly by extensive damage, causing the cell to kill itself). Often cancer will develop when genetic mutations or other cellular events render the cells unable to die by apoptosis. My research investigates a novel gene therapy that will restore the cancer cell’s ability to die by apoptosis, while limiting …

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The Inhibitory Affects Of Phytochemicals Against A Carcinogen By The Modulation Of Xenobiotic Enzymes In Hepg2 Cells, Jon Ahlstrom, Dr. Kim O'Neill Jan 2014

The Inhibitory Affects Of Phytochemicals Against A Carcinogen By The Modulation Of Xenobiotic Enzymes In Hepg2 Cells, Jon Ahlstrom, Dr. Kim O'Neill

Journal of Undergraduate Research

Cancer is the cause of death of 1 in 3 citizens in the United States. A diet rich in fruits and vegetables can reduce cancer deaths by 33%. Cancer prevention from dietary plants may in part be derived from individual phytochemicals inherent to the plant. The identification of plant phytochemicals that have anti-cancer properties and their mode of action is an important area of cancer research.

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Antibiotic Resistance In Escherichia-Coli Isolates From Guatemala, Troy Russon, Dr. Ronald Leavitt Jan 2014

Antibiotic Resistance In Escherichia-Coli Isolates From Guatemala, Troy Russon, Dr. Ronald Leavitt

Journal of Undergraduate Research

It is estimated that at least one-half of all antibiotic use in the United States is inappropriate.1 Physicians often prescribe broad spectrum antibiotics when the disease causing bacterial strain could be targeted specifically. Also, patients are prone to expect prescriptions for antibiotics even when their infections are viral, such as the common cold. While the United States and most industrialized nations require prescriptions for antimicrobial drug use, most developing countries do not. It is reasonable to hypothesize that drug resistance in these countries may be occurring at a more accelerated rate.2 I tested Escherichia-coli isolates from Guatemala for resistance to …

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In Vitro Effects Of Follicular Dendritic Cells On Proliferation Of Hiv Infected T Cells, Jesse Rowley, Dr. Gregory Burton Jan 2014

In Vitro Effects Of Follicular Dendritic Cells On Proliferation Of Hiv Infected T Cells, Jesse Rowley, Dr. Gregory Burton

Journal of Undergraduate Research

Human Immunodeficiency Virus (HIV), the cause of AIDS, has eluded successful treatment since its discovery in the early 1980s. HIV is a retrovirus that infects and eventually destroys CD4+ T cells. In HIV infected individuals it is believed that during the longest phase of infection (latency) most viral production takes place in and around the germinal centers of secondary lymphoid tissues. Follicular dendritic cells (FDCs) are a unique component of the germinal center, and previous studies done in our laboratory have suggested that FDCs may augment viral replication and/or infection within the germinal center.

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Ancient Egyptian Textiles: A Genetic Look Into 2000-Year-Old Egyptian Communities, Shaun Odell, Dr. Scott Woodward Jan 2014

Ancient Egyptian Textiles: A Genetic Look Into 2000-Year-Old Egyptian Communities, Shaun Odell, Dr. Scott Woodward

Journal of Undergraduate Research

In the mid 1980’s archeologists from BYU began excavating a 2000-year-old burial site in Northern Egypt called the Fag-el-Gamous cemetery. This cemetery contains the remains of roughly 350,000 individuals who had been buried there between 200 BC and 400 AD during the Greco-Roman period of Egyptian history. The chemical composition of the desert, as well as the hot, dry climate, naturally mummified not only the individuals of focus, but also numerous textile samples found on the mummies. Excavation of this sight has proceeded from that time, providing unique opportunities for study of ancient Egyptian culture.

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Preventing Salmonella And Other Bacterial Contamination In Poultry Using A High-Adhering Strain Of Escherichia Coli, Jeffrey P. North, Dr. Ron Leavitt Jan 2014

Preventing Salmonella And Other Bacterial Contamination In Poultry Using A High-Adhering Strain Of Escherichia Coli, Jeffrey P. North, Dr. Ron Leavitt

Journal of Undergraduate Research

In 1928 Alexander Fleming revolutionized the world with the discovery of penicillin. Penicillin and the antibiotics discovered thereafter revolutionized the treatment of infectious diseases. Equipped with these miracle drugs, scientists thought the battle against pathogenic bacteria was won. However, bacteria began to evolve to meet the antibiotic challenge. As the 20th century progressed, more and more bacteria developed resistance to one or more antibiotics. This resistance is achieved through mutation or through horizontal gene transfer, when one bacterium transfers the gene to another bacterium.

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Follicular Dentritic Cells And Retention Of Hiv Quasi-Species, Candace Mcnaughton, Dr. Gregory Burton Jan 2014

Follicular Dentritic Cells And Retention Of Hiv Quasi-Species, Candace Mcnaughton, Dr. Gregory Burton

Journal of Undergraduate Research

HIV infects millions of people worldwide; in the year 2000 alone, more than 3 million people died from AIDS (Acquired Immunodeficiency Syndrome) as a result of HIV infection1. In countries, such as the United States, where effective treatment is affordable, highly active antiretroiviral therapy (HAART) can reduce viral blood loads to currently undetectable levels2. Unfortunately, the side effects of HAART can be severe, resulting in noncompliance, and upon its termination, HIV levels rapidly rebound. Several viral reservoirs within the body have been identified, including the follicular dendritic cell (FDC) network3. FDCs trap HIV antibody complexes for long periods of time …

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Epigallocatechin Gallate, A Green Tea Polyphenol, Causes Direct Dna Damage At Physiological Concentrations, Jeremy Mcbride, Dr. Kim L. O'Neill Jan 2014

Epigallocatechin Gallate, A Green Tea Polyphenol, Causes Direct Dna Damage At Physiological Concentrations, Jeremy Mcbride, Dr. Kim L. O'Neill

Journal of Undergraduate Research

Epigallocatechin gallate (EGCG) is a polyphenol found in green tea. Because tea is ingested by over two thirds of the world’s population, considerable research has been done to identify and characterize the active components of the second most widely consumed beverage (1). Among the many chemopreventative properties that have been attributed to green tea, and EGCG, this botanical product has been established as an antimutagen and a potent free-radical scavenger that has been shown to effectively quench reactive oxygen and nitrogen species that may otherwise damage DNA and other sensitive biomolecules. Such damage, accumulated over time, may lead to mutagenesis …

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The Effects Of Concurrent Treatment Of Caffeine And Various Apoptotic-Inducing Drugs In The Molt-4 Cell Line, Janet L. Hart, Dr. Kim L. O'Neill Jan 2014

The Effects Of Concurrent Treatment Of Caffeine And Various Apoptotic-Inducing Drugs In The Molt-4 Cell Line, Janet L. Hart, Dr. Kim L. O'Neill

Journal of Undergraduate Research

Apoptosis is the method by which cells undergo programmed cell death or “cell suicide.” The cell initiates apoptosis after there is irreparable damage or if the cell is simply not needed. Some insults that are known to induce apoptosis are irradiation, heat shock, as well as many chemotherapeutic drugs including staurosporine, paclitaxel, and dexamethasone. The precise regulation of apoptosis is critical, as disregulation can lead to many diseases or conditions including autoimmune disorders or cancer.

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Bench Top Bioremediation Of Trichloroethylene, Colin Jones, Dr. Alan Harker Jan 2014

Bench Top Bioremediation Of Trichloroethylene, Colin Jones, Dr. Alan Harker

Journal of Undergraduate Research

The initial aim of the project was to compare degradation rates of trichloroethylene (TCE) using two different bacterial strains. After four months of research, my greatest find concerns how to build an effective reactor. After the reactor was constructed, time allowed only focusing on the genetically engineered bacterium and not on the wild type. Perhaps a better title for my final report to ORCA would be “Bench Top Bio-reactors, How Not to Build One.”

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Antigenotoxic Effects Of Diallyl Disulfide And Allyl Disulfide On Benzo (A) Pyrene Induced Dna Damage In Hepg2 Cells As Measured By The Single Cell Gel Electrophoresis Assay, Corey W. Speers, Dr. Kim L. O'Neill Jan 2014

Antigenotoxic Effects Of Diallyl Disulfide And Allyl Disulfide On Benzo (A) Pyrene Induced Dna Damage In Hepg2 Cells As Measured By The Single Cell Gel Electrophoresis Assay, Corey W. Speers, Dr. Kim L. O'Neill

Journal of Undergraduate Research

One of the most effective strategies in cancer control is chemoprevention. Previous studies have shown naturally occurring organosulfur compounds from garlic and onion to be effective against carcinogenesis. The effects of two of these organosulfur compounds, diallyl sulfide (DAS) and diallyl disulfide (DADS), are thought to be of especial worth. Their anti-carcinogenic effects in the human cell line HepG2 are, however, less understood. HepG2 cells are human hepatoblastoma cells that have maintained their xenobiotic metabolizing competence. Because they are similar in function to cells obtained from human liver tissue, they are ideal for research in vitro. Benzo[a]pyrene (B[a]P) is an …

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Investigation Into The Anti-Angiogenic Activities Of Convolvulus Arvensis Extract, Jeremy F. Mcbride, Rachelle R. Olsen, Dr. Kim L. O'Neill Jan 2014

Investigation Into The Anti-Angiogenic Activities Of Convolvulus Arvensis Extract, Jeremy F. Mcbride, Rachelle R. Olsen, Dr. Kim L. O'Neill

Journal of Undergraduate Research

Angiogenesis, the development and differentiation of new blood vessels from the pre-existing vasculature, is a fundamental physiological process involved in growth, development, and wound healing. Loss of control over the biological molecules which regulate this process can lead to pathologic angiogenesis, or neoangiogenesis, a process associated with such diseases as retinopathies, psoriasis, arthritis, and most importantly, cancer.

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Determination Of The Proteins That Bind To The Fg Enhancer Region Of The Col11a2 Gene, Eric Freeman, Dr. Laura Bridgewater Jan 2014

Determination Of The Proteins That Bind To The Fg Enhancer Region Of The Col11a2 Gene, Eric Freeman, Dr. Laura Bridgewater

Journal of Undergraduate Research

Collagen is the most abundant protein found in the human body and is responsible for the development of bone and cartilage. The Col11a2 gene is one of the many genes that participate in the formation of collagen. Mutations in this gene can cause a variety of cartilage diseases and disorders such as cleft palate, hearing loss, osteoarthritis, and perhaps even prenatal lethal chondrodysplasia. Arthritis alone is “the leading cause of work-related disability and the leading cause of disability in persons >65 years in the United States”.i The deadly effects of these mutations warrant a more in-depth study of the …

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Analysis Of Unique Genome Segments Of Burkholderia Mallei Obtained From Amplified Fragment Length Polymorphism, Benjamin Nelson Kartchner, Dr. Richard A. Robison Jan 2014

Analysis Of Unique Genome Segments Of Burkholderia Mallei Obtained From Amplified Fragment Length Polymorphism, Benjamin Nelson Kartchner, Dr. Richard A. Robison

Journal of Undergraduate Research

Burkholderia mallei the etiological agent of the disease glanders, has the capability to cause disease in both animals and humans. Infection is usually caused through inhalation of organisms present in aerosols which results in serious pulmonary and systemic conditions that results in 40% mortality even with vigorous antimicrobial intervention and rises above 90% without such therapy(2). In addition, because of their dangerous nature both organisms have emerged as possible agents which may be used in the production of biological weapons. Recent research conducted in Dr. Richard Robison’s lab has analyzed genomic relatedness in various strains of B. mallei and the …

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Concomitant Treatment Of Non-Steroidal Anti-Inflammatory Drugs And Chemotherapeutics On Human Acute T Lymphocytes., Janet L. Hart, Dr. Kim L. O'Neill Jan 2014

Concomitant Treatment Of Non-Steroidal Anti-Inflammatory Drugs And Chemotherapeutics On Human Acute T Lymphocytes., Janet L. Hart, Dr. Kim L. O'Neill

Journal of Undergraduate Research

Non-steroidal anti-inflammatory drugs (NSAIDs) such as sulindac and acetylsalicylic acid (ASA) are frequently used to relieve pain, clotting, fever and inflammation. Recently, NSAIDs have been shown to decrease the occurrence of colorectal cancer and inhibit mammary cancer in rats. To elucidate this mechanism, further research has been done to show an inhibition of matrix metalloproteinases (MMPs) by NSAIDs in lung and prostate carcinomas. Many current chemotherapeutic agents such as doxorubicin and methotrexate (DOX and MTX respectively) rely on the Fas/FasL (CD95) pathway to induce cell death. Because MMPs are able to cleave membrane-bound Fas, these chemotherapeutics are less-effective.

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Fdcs In Hiv Infected Patients Retain Archival Hiv Sequences, Jesse Rowley, Dr. Gregory Burton Jan 2014

Fdcs In Hiv Infected Patients Retain Archival Hiv Sequences, Jesse Rowley, Dr. Gregory Burton

Journal of Undergraduate Research

Human Immunodeficiency Virus (HIV), the causative agent of AIDS, has eluded successful treatment since its discovery in the early 1980s. The prospect of successful treatment came with the advent of Highly Active Anti-Retroviral Therapy (HAART) which has reduced plasma virus replication to undetectable levels in many patients. Although virus may be maintained below detectable levels for years by treatment, complete viral clearance has not been achieved. “Hidden” reservoirs of non-replicating or slowly replicating virus escape rigorous drug treatment. When the patient is taken off of anti-retroviral therapy, plasma virus levels will return to pre-therapy levels and HIV will continue the …

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Locating The High Adherence Genes On Pha-28, Jonathan Walter Dukes, Dr. Ronald Leavitt Jan 2014

Locating The High Adherence Genes On Pha-28, Jonathan Walter Dukes, Dr. Ronald Leavitt

Journal of Undergraduate Research

Bacterial high adherence is an important of research because of its effect on bacterial pathogenesis and intestinal colonization. In the laboratory of Dr. Ronald Leavitt, we have been studying the ability of certain bacteria to prevent the colonization of intestinal epithelial cells by other bacteria. Of particular interest to us are non-pathogenic Escherichia coli strains that have the ability to out compete and overrun colonies of Salmonella, as well as the colonies of the pathogenic E. coli strains that cause the turkey disease colibacillosis. Such E. coli have the potential to be used as an interfering agent against Salmonella and …

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Sub Cellular Localization Of A Putative Single Stranded Dna Binding Protein From Arabidopsis Thaliana, Andrew C. Edmondson, Dr. Brent L. Nielsen Jan 2014

Sub Cellular Localization Of A Putative Single Stranded Dna Binding Protein From Arabidopsis Thaliana, Andrew C. Edmondson, Dr. Brent L. Nielsen

Journal of Undergraduate Research

DNA recombination is the exchange of segments between homologous pieces of DNA, resulting in variations in genetic diversity. Recombination provides essential genetic variation, but can also cause harmful rearrangements, resulting in genetic disorders in mammals, plants and yeast. DNA recombination in plant mitochondria is supported by a variety of evidence, but the mechanisms are poorly understood. Due to evidence of an evolutionary relationship between bacteria and mitochondria, a RecA mechanism has been proposed for mitochondrial recombination. This is supported by a similar mechanism in chloroplasts.

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Analysis Of The Binding Of Sox9 To Enhancer Regions In The Col11a2 Gene By In Vivo Cross-Linking, Alisha Clinger, Dr. Laura Clark Bridgewater Jan 2014

Analysis Of The Binding Of Sox9 To Enhancer Regions In The Col11a2 Gene By In Vivo Cross-Linking, Alisha Clinger, Dr. Laura Clark Bridgewater

Journal of Undergraduate Research

Improper development of collagen is the cause for many cartilage-based diseases, including osteoarthritis as wells as various skeletal disorders. The Col11a2 (type XI collagen á2 subunit) gene is critical to cartilage development and is necessary for cartilage cells to be able to perform their specific functions (1,5). The development of collagen is controlled by the regulation of various collagen genes by specific proteins. Certain proteins bind to regions in the DNA called enhancers and promoters and this activates the gene. Dr. Laura Bridgewater’s laboratory at Brigham Young University has analyzed three enhancer regions for the Col11a2 gene. Each of these …

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Sequence Analysis Of Hiv Quasi Species In Vivo, Eryn Barber Hadley, Dr. Greg Burton Jan 2014

Sequence Analysis Of Hiv Quasi Species In Vivo, Eryn Barber Hadley, Dr. Greg Burton

Journal of Undergraduate Research

Human Immunodeficiency Virus (HIV) is the causative agent of Acquired Immunodeficiency Syndrome (AIDS). There is currently no cure for HIV infection, and AIDS has been reported as the fourth highest killer in the world [1]. The initial success of the drug cocktail used in Highly Active Anti-Retroviral Therapy (HAART) has made the possibility of a cure for AIDS seem attainable, however the persistence of virus reservoirs makes this extremely difficult and leads to a rebound of viral load [2]. The known reservoirs of HIV include latently infected T cells, macrophages and follicular dendritic cells.

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Fc Receptors In Hiv Trapping And Retention On Follicular Dendritic Cells, Daniel Willis, Dr. Gregory Burton Jan 2014

Fc Receptors In Hiv Trapping And Retention On Follicular Dendritic Cells, Daniel Willis, Dr. Gregory Burton

Journal of Undergraduate Research

The development of HighlyActive Antiretroviral Therapy (HAART) against the HIV virus created a temporary excitement regarding a possible cure for HIV. This optimism resulted due to the fact that HAART blocked active HIV replication and reduced the level of HIV in the bloodstream to below standard limits of detection. However, it was soon discovered that HIV blood levels were restored shortly after cessation of HAART. This led to the discovery of HIV reservoirs, or sites where latent virus is harbored. It is this harbored virus that actively replicates and replenishes HIV viral loads when HAART is discontinued.

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Follicular Dendritic Cells (Fdcs) And Sparing Of Cd4+ T Cells From Hiv/Cd62l Triggered Apoptosis, Devon C. Cole, Dr. Grey Burton Jan 2014

Follicular Dendritic Cells (Fdcs) And Sparing Of Cd4+ T Cells From Hiv/Cd62l Triggered Apoptosis, Devon C. Cole, Dr. Grey Burton

Journal of Undergraduate Research

Both B and T lymphocytes intimately interact with follicular dendritic cells (FDCs) in lymphoid follicles of secondary lymphoid tissue (e.g., spleen, lymph node, and tonsils). FDCs trap and retain antigens needed to induce and maintain potent memory antibody responses. FDCs contribute both antigen dependent and independent signals to B lymphocytes residing in the microenviroment of germinal centers in secondary lymphoid tissue, which contributes to the optimal activation of these cells as well as T lymphocytes. One important contribution of FDCs to B lymphocytes is signaling that spares these cells from programmed cell death. As B cells differentiate in germinal centers, …

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The Effects Of Phorbol Esters On Cotton Tail Rabbit Papillomas, Cory Funk, Dr. Richard Robison Jan 2014

The Effects Of Phorbol Esters On Cotton Tail Rabbit Papillomas, Cory Funk, Dr. Richard Robison

Journal of Undergraduate Research

Papillomas are virus-induced benign tumors or lesions of the skin and mucous membranes, more commonly known as warts. Most everyone has personally experienced a papilloma virus infection at some point in his or her life. We normally do not think of warts as a health concern because they do not affect our general health. Although this is true for most papillomas, it is not the case with many types of genital warts. It has been well documented that genital warts caused by Human Papilloma Virus (HPV) types such as 16, 18 and 31 are directly linked to malignant cancers (3, …

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Reduction In Toxicity Of Doxorubicin By Á-Tocopherol Succinate (Vitamin E) And Ascorbic Acid (Vitamin C) In Human Adenocarcinoma Cells, Christie Michaud, Dr. Byron Murray Jan 2014

Reduction In Toxicity Of Doxorubicin By Á-Tocopherol Succinate (Vitamin E) And Ascorbic Acid (Vitamin C) In Human Adenocarcinoma Cells, Christie Michaud, Dr. Byron Murray

Journal of Undergraduate Research

Colorectal cancer is the second leading cause of cancer deaths in the United States and doxorubicin, is one of the more widely chemotherapeutic treatments for this disease. This study investigated the possibility of exposing adenocarcinoma cells to vitamin C/vitamin E (VC/VE) combinations as a means to reduce toxicity associated with doxorubicin (DXR) treatment.

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Hepatic Oval Cells: A Potential Source Of Cartilage, Chris Meinhart, Dr. Laura C. Bridgewater Jan 2014

Hepatic Oval Cells: A Potential Source Of Cartilage, Chris Meinhart, Dr. Laura C. Bridgewater

Journal of Undergraduate Research

Damage to articular cartilage found in synovial joints can occur both by trauma and disease processes. Cartilage, because of its avascular nature and low cellularity, has very poor regeneration capabilities. It is therefore important to explore new and effective cellular therapies to facilitate the repair of diseased or otherwise damaged cartilage.

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Identification Of A Novel Positive Cis-Acting Element In The First Intron Of The Mouse Col11a2 Gene, Steven Alan Smith, Dr. Laura Bridgewater Jan 2014

Identification Of A Novel Positive Cis-Acting Element In The First Intron Of The Mouse Col11a2 Gene, Steven Alan Smith, Dr. Laura Bridgewater

Journal of Undergraduate Research

Three chondrocyte-specific enhancer elements were previously identified in the mouse type XI collagen gene, Col11a2 (1-3). Enhancer elements are base pair sequences of DNA to which proteins bind enhancing expression of a particular gene. One of these enhancers, called F/G, is located in the first intron of that gene (3). This work has revealed the likely presence of additional positive cis-acting (enhancer) elements in the first intron, and one of those elements has been identified.

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Fdc As An Hiv Reservoir: Dna Sequence Analysis Of Hiv Isolated From Fdc And Cd4+ T Cells Of Infected Patient, Trever Bradley Burgon, Dr. Gregory F. Burton Jan 2014

Fdc As An Hiv Reservoir: Dna Sequence Analysis Of Hiv Isolated From Fdc And Cd4+ T Cells Of Infected Patient, Trever Bradley Burgon, Dr. Gregory F. Burton

Journal of Undergraduate Research

Human Immunodeficiency Virus (HIV), the retrovirus that causes Acquired Immunodeficiency Syndrome (AIDS), has infected over 60 million people and become what the Joint United Nations Program on HIV/AIDS calls: “the most devastating disease mankind has ever faced” (8). Current treatment, known as HAART (highly active antiretroviral therapy), is able to reduce HIV in the blood to undetectable levels but it cannot completely block replication nor remove HIV from the body. When patients stop taking HAART, their viral load (the quantity of virus detected in their blood) and symptoms quickly return to pretreatment levels. This viral rebound is caused by latent …

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The Potential For Grape Seed Extract As An Antioxidant In Human Cells, Mark J. Eliason, Dr. Kim O'Neill Jan 2014

The Potential For Grape Seed Extract As An Antioxidant In Human Cells, Mark J. Eliason, Dr. Kim O'Neill

Journal of Undergraduate Research

The single-cell gel electrophoresis assay or “Comet Assay” is a novel test which can be used to empirically ascertain the degree of damage sustained by the DNA of individual cells when exposed to cytotoxic chemicals. In this experiment a known cell line was grown in varying concentrations of grape seed extract (GSE), a reputed antioxidant, and then exposed to hydrogen peroxide, an oxidant, known to cause breaks in the DNA. When the comet assay was subsequently run the effect that the varying concentrations of grape seed extract had in protecting the cells from damage could be quantified.

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Hiv In The Immune System: The Role Of Specialized Follicular Dendritic Cells In Promoting Viral Disease, Jacob D. Estes, Dr. Gregory F. Burton Jan 2014

Hiv In The Immune System: The Role Of Specialized Follicular Dendritic Cells In Promoting Viral Disease, Jacob D. Estes, Dr. Gregory F. Burton

Journal of Undergraduate Research

Human Immunodeficiency Virus (HIV) has become a world wild epidemic affecting millions of people across the globe. Even in the face of potent antiviral drugs which are only available in first world countries, HIV continues to evade intervention strategies and eventually destroy the body’s immune system. During the longest stage of HIV disease, clinical latency, much of active infection is confined to the germinal centers of secondary lymphoid tissue (1). Here HIV is trapped on the surface of follicular dendritic cells (FDC) which reside in this region of all secondary lymphoid organs (2). Large amounts of HIV localize on FDC …

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Identification Of The Binding Partners For Hspb2 And Cryab Reveals Myofibril And Mitochondrial Protein Interactions And Non-Redundant Roles For Small Heat Shock Proteins, Kelsey Murphey Langston Dec 2013

Identification Of The Binding Partners For Hspb2 And Cryab Reveals Myofibril And Mitochondrial Protein Interactions And Non-Redundant Roles For Small Heat Shock Proteins, Kelsey Murphey Langston

Theses and Dissertations

Small Heat Shock Proteins (sHSP) are molecular chaperones that play protective roles in cell survival and have been shown to possess chaperone activity. As such, mutations in this family of proteins result in a wide variety of diseases from cancers to cardiomyopathies. The sHSPs Beta-2 (HspB2) and alpha-beta crystalline (CryAB) are two of the ten human sHSPs and are both expressed in cardiac and skeletal muscle cells. A heart that cannot properly recover or defend against stressors such as extreme heat or cold, oxidative/reductive stress, and heavy metal-induced stress will constantly struggle to maintain efficient function. Accordingly, CryAB is required …

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