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Articles 1 - 5 of 5
Full-Text Articles in Microbiology
Effects Of Diabetic State And Gender On Pro-Inflammatory Cytokine Secretion By Human Macrophages Infected With Burkholderia Pseudomallei, Annette J. Blam
Effects Of Diabetic State And Gender On Pro-Inflammatory Cytokine Secretion By Human Macrophages Infected With Burkholderia Pseudomallei, Annette J. Blam
Theses and Dissertations
Burkholderia pseudomallei is a gram-negative opportunistic soil pathogen that causes the life-threatening disease melioidosis. It is endemic in Northern Australia and Southeast Asia but can be found throughout many other regions in the world. Diabetes mellitus is a predisposing risk factor for infection with this organism and it has been demonstrated that diabetic males are particularly susceptible to severe infection. Previous research suggested that monocytes isolated from the whole blood of diabetic males demonstrated a decreased ability to produce the proinflammatory cytokines IL-1β and IL-8. We hypothesized that monocyte-derived macrophages from diabetic males would also secrete lower levels of pro-inflammatory …
Determining The Function Of Nuclear Bmp4, Trina Jane Loos
Determining The Function Of Nuclear Bmp4, Trina Jane Loos
Theses and Dissertations
Bone morphogenetic protein 4 (Bmp4) is a well known growth factor that regulates gene expression through the SMAD signaling pathway. Bmp4 is involved in many developmental processes and has been identified as an important factor in several cancers, including melanoma, ovarian cancer, and colon cancer. Madoz-Gurpide et al. recently observed Bmp4 in the nuclei of a minor percentage of cells in colon cancer tissues. In addition, our lab has recently discovered a nuclear variant of Bmp2 (nBmp2), the TGF-β family member most closely related to Bmp4. These observations led us to hypothesize that a nuclear variant of Bmp4 (nBmp4) also …
Interactions Of Burkholderia Pseudomallei And Acanthamoeba Castellanii And Their Effects On Virulence In Human Monocytes, Emily Ann Moore
Interactions Of Burkholderia Pseudomallei And Acanthamoeba Castellanii And Their Effects On Virulence In Human Monocytes, Emily Ann Moore
Theses and Dissertations
Burkholderia pseudomallei, the etiological agent of melioidosis, is a saprophytic bacterium existing endemically in the water and soil of SE Asia and Northern Australia. This organism has shown the ability to remain dormant in its host for decades. B. thailandensis is a closely related non-pathogenic near neighbor that is also found in these soils. It has been suggested that free-living amoeba could be natural reservoirs for these organisms. The interactions of Burkholderia species and Acanthamoeba castellanii, a species of free-living amoeba, were studied to better understand the natural ecology of these organisms and to determine the effects amoeba …
Organellar Dna Polymerases Gamma I And Ii In Arabidopsis Thaliana, Jeffrey M. Brammer
Organellar Dna Polymerases Gamma I And Ii In Arabidopsis Thaliana, Jeffrey M. Brammer
Theses and Dissertations
Plants have two organelles outside the nucleus which carry their own DNA, mitochondria and chloroplasts. These organelles are descendants of bacteria that were engulfed by their host according to the endosymbiotic theory. Over time, DNA has been exchanged between these organelles and the nucleus. Two polymerases, DNA Polymerases Gamma I and II, are encoded in the nucleus and remain under nuclear control, but are transported into the mitochondria and chloroplasts. DNA polymerases gamma I and II are two organelle polymerases which have been studied through sequence analysis and shown to localize to both mitochondria and chloroplasts. Little has been done …
Gene Expression Patterns In Flea Vectors Of Yersinia Pestis, Wei Zhou
Gene Expression Patterns In Flea Vectors Of Yersinia Pestis, Wei Zhou
Theses and Dissertations
Plague bacteria (Yersinia pestis) are transmitted to susceptible mammals by fleas. At least 25 flea species found in North America have been identified as plague vectors. The most efficient flea vector is the Oriental rat flea Xenopsylla cheopis, while the cat flea Ctenocephalides felis is a poor vector. The factors that determine vector competence of different fleas are not known. The main obstacles that the bacteria must overcome in the flea gut are also unknown. Fleas' molecular responses to Y. pestis invading could be a determining factor to control the bacterial survival and growth. Good and poor …