Genetics and Genomics Commons^™

Bad Ethics, Good Ethics And The Genetic Engineering Of Animals In Agriculture, Bernard Rollin

Genetics Collection

Genetic engineers have been remiss in addressing ethical and social issues emerging from this powerful new technology, a technology whose implications for agriculture are profound. As a consequence of this failure, society has been uneasy about genetic engineering of animals and has had difficulty distinguishing between genuine and spurious ethical issues the technology occasions. Many of the most prominent concerns do not require a serious response. On the other hand, concerns about a variety of possible risks arising from genetic engineering of animals require careful consideration and dialogue with the public. Such concerns are an admixture of ethics and prudence. …

A Report On The Issues Affecting The Use Of The Dampier Archipelago, Peter Driscoll

Fisheries Management Papers

This report was commissioned by the Minister for Fisheries following concerns about resource sharing, allocation of licences and leases for pearling and aquaculture, recreational and commercial fishing opportunities, and local residents continued ability to access the islands and marine areas of the Dampier Archipelago. The purpose of this report is to provide a scoping document for a marine planning study for the Dampier Archipelago for the Fisheries Department and the Minister for Fisheries.

Fishermen's Views On The Future Management Of The Rock Lobster Fishery: A Report Prepared On Behalf Of The Rock Lobster Industry Advisory Committee, The Marketing Centre, Rock Lobster Industry Advisory Committee

Fisheries Management Papers

In June 1995, a self-completion survey of fishermen in the rock lobster fishery was sent out by The Marketing Centre to 589 licensees. A total of 206 valid responses were received. The questionnaire was fairly long and dealt with a number of complex issues. As such, this response rate of 36.0% compares favorably with the average for postal surveys of around 40.0%. The following represents the main findings from the survey.

Same Fish - Different Rules - Proceedings Of The National Fisheries Management Network Workshop Held As Part Of The Third Australasian Fisheries Managers Conference August 1995, F. B. Prokop

Fisheries Management Papers

This workshop represents the third time that a specific recreational fisheries workshop has been held in conjunction with the Australasian Fisheries Managers Conference. It is designed to analyse the different management approaches from the various fisheries agencies which have responsibility for selected species. The case studies that make up the workshop have been selected to represent the diversity of situations including freshwater, marine, pelagic and invertebrate species.

Interactions Involving The Human Rna Polymerase Ii Transcription/Nucleotide Excision Repair Complex Tfiih, The Nucleotide Excision Repair Protein Xpg, And Cockayne Syndrome Group B (Csb) Protein, Narayan Iyer, Michael S. Reagan, Kou-Juey Wu, Bertram Canagarajah, Errol C. Friedberg

Biology Faculty Publications

The human basal transcription factor TFIIH plays a central role in two distinct processes. TFIIH is an obligatory component of the RNA polymerase II (RNAP II) transcription initiation complex. Additionally, it is believed to be the core structure around which some if not all the components of the nucleotide excision repair (NER) machinery assemble to constitute a nucleotide excision repairosome. At least two of the subunits of TFIIH (XPB and XPD proteins) are implicated in the disease xeroderma pigmentosum (XP). We have exploited the availability of the cloned XPB, XPD, p62, p44, and p34 genes (all …

Balancing The Scales: Access And Equity In Fisheries Management - Proceedings Of The Third Australasian Fisheries Managers Conference, Rottnest Island, Western Australia, 2-4 August 1995, Patricia Summerfield

Fisheries Management Papers

The papers reproduced in this volume were presented at the Third Australasian Fisheries Managers Conference held at Kingstown Environmental Education Centre, Rottnest Island, Western Australia, from 2-4 August 1995. Two presentations have not been received in full written form and one paper was not available for publication due to copyright being held elsewhere. Abstracts of these papers are included in the proceedings. The papers are arranged in order of presentation at the Conference. The scenarios used in the workshop sessions are reproduced at the end of the proceedings for information.

Management Arrangements For Specimen Shell Collection In Western Australia, 1995, Jonathon Hs Barrington, C A. Campbell

Fisheries Management Papers

The Specimen Shell Fishery in Western Australia is based on the collection of marine species of the phylum Mollusca for the purposes of display, collection, cataloguing, classification and sale. Specimen shells may be alive or dead at the time of take and include beach-washed shells. Fossilised shells do not constitute specimen shells. This document has been prepared to detail the legislative requirements of the Western Australian Government, as well as to fulfill the requirements under the Commonwealth Wildlife Protection (Regulation of Exports and Imports) Act 1982 to allow for the export of specimen shells from Western Australian waters and the …

A New Species Of Rock-Dwelling Phyllodactylus (Squamata: Gekkonidae) From The Richtersveld, South Africa, Aaron M. Bauer, William R. Branch, David A. Good

Occasional Papers of the Museum of Natural Science, Louisiana State University

No abstract provided.

A Miocene Hedgehog (Mammalia: Erinaceidae) From Fort Polk In Western Louisiana, Judith A. Schiebout

Occasional Papers of the Museum of Natural Science, Louisiana State University

No abstract provided.

Genome-Wide High-Resolution Mapping By Recurrent Intermating Using Arabidopsis Thaliana As A Model, Sin-Chieh Liu, Stanley Kowalski, Tien-Hung Lan, Kenneth A. Feldmann, Andrew H. Patterson

Law Faculty Scholarship

We demonstrate a method for developing populations suitable for genome-wide high-resolution genetic linkage mapping, by recurrent intermating among F2 individuals derived from crosses between homozygous parents. Comparison of intermated progenies to F2 and “recombinant inbred” (RI) populations from the same pedigree corroborate theoretical expectations that progenies intermated for four generations harbor about threefold more information for estimating recombination fraction between closely linked markers than either RI-selfed or F2 individuals (which are, in fact, equivalent in this regard) . Although intermated populations are heterozygous, homozygous “intermated recombinant inbred” (IN) populations can readily be generated, combining additional information afforded by intermating with …

Heat Shock Factor Gains Access To The Yeast Hsc82 Promoter Independently Of Other Sequence-Specific Factors And Antagonizes Nucleosomal Repression Of Basal And Induced Transcription, Alexander M. Erkine, C. C. Adams, T. Diken, D. S. Gross

Scholarship and Professional Work – COPHS

Transcription in eukaryotic cells occurs in the context of chromatin. Binding of sequence-specific regulatory factors must contend with the presence of nucleosomes for establishment of a committed preinitiation complex. Here we demonstrate that the high-affinity binding site for heat shock transcription factor (HSF) is occupied independently of other cis-regulatory elements and is critically required for preventing nucleosomal assembly over the yeast HSC82 core promoter under both noninducing (basal) and inducing conditions. Chromosomal mutation of this sequence, termed HSE1, erases the HSF footprint and abolishes both transcription and in vivo occupancy of the TATA box. Moreover, it dramatically reduces promoter chromatin …

Ewe Fertility In The Star Accelerated Lambing System, R. M. Lewis, D. R. Notter, D. E. Hogue, B. H. Magee

Department of Animal Science: Faculty Publications

Effects of environmental factors such as ewe age, season of exposure, and time from lambing to exposure on fertility were evaluated using records on 1,084 Dorset ewes in the STAR accelerated lambing system. The STAR program consisted of five 30-d concurrent breeding and lambing periods per year beginning on January 1, March 15, May 27, August 8, and October 20. Fertility in the flock changed in a cyclic and predictable fashion during the year. Changes in prolificacy were less consistent but also tended to show cyclic variation. Matings that occurred within the typical breeding season (August, October, and January) were …

Rosalind Elsie Franklin (1920-1958) Biologist, Margaret Sylvia

Faculty Publications

A biography of the biologist Rosalind Elsie Franklin whose work on x-ray crystallography contributed to Watson and Crick's elucidation of the structure of DNA.

Stand Hazard Rating For Central Idaho Forests, Robert Steele, Ralph E. Williams, Julie C. Weatherby, Elizabeth D. Reinhardt, James T. Hoffman, R. W. Thier

Aspen Bibliography

No abstract provided.

Fire-Bgc--A Mechanistic Ecological Process Model For Simulating Fire Succession On Coniferous Forest Landscapes Of The Northern Rocky Mountains, Robert E. Keane, Penelope Morgan, Steven W. Running

Aspen Bibliography

An ecological process model of vegetation dynamics mechanistically simulates long-term stand dynamics on coniferous landscapes of the Northern Rocky Mountains. This model is used to investigate and evaluate cumulative effects of various fire regimes, including prescribed burning and fire exclusion, on the vegetation and fuel complex of a simulation landscape composed of many stands. Detailed documentation of the model FIRE-BGC (a FIRE BioGeoChemical succession model) with complete discussion of all model parameters is followed with results of an application of the FIRE-BGC to a whitebark pine landscape in the Bob Marshall Wilderness Complex. Simulation results of several management scenarios are …

Waste-Wood-Derived Fillers For Plastics, Brent English, Craig M. Clemons, Nicole Stark, James P. Schneider

Aspen Bibliography

Filled thermoplastic composites are stiffer, stronger, and more dimensionally stable than their unfilled counterparts. Such thermoplastics are usually provided to the end-user as a precompounded, pelletized feedstock. Typical reinforcing fillers are inorganic materials like talc or fiberglass, but materials derived from waste wood, such as wood flour and recycled paper fiber, are also effective as fillers. The goal of this project was to generate commercial interest in using waste-wood–paper-derived fillers (WPFs) to reinforce thermoplastics. The research strategy was twofold: developmental research and outreach. Specific objectives were (1) to improve wastepaper fiber preparation, feeding, and compounding methods, and optimize composite performance, …

Soldier's Guide To Wildlands Of Camp W. G. Williams, Thomas Hysell, Margaret Pettis

Aspen Bibliography

No abstract provided.

A Gene Correlate Of Geotaxis Near Adh (2-50.1) In Drosophila Melanogaster, Scott F. Stoltenberg, Jerry Hirsch

Department of Psychology: Faculty Publications

As part of a long-term study (38+ years) to identify genetic correlates of geotaxis in Drosophila melanogaster, the investigators report the results of allozyme-level analyses of 2 lines derived from hybridizing high- and low-selected lines that have evolved stable, extreme expressions of geotaxis. Allelic variation at Adh was associated with geotactic performance in 1 hybrid-derived line, but not in another, after 66 free-mating generations beyond the F₂ generation. A second-chromosome gene correlate of geotaxis may lie within 1 map unit of Adh. Population genetic analyses suggest that there were different selection pressures on the hybrid-derived lines and …

Molecular Differentiation Of Alfalfa Weevil Strains (Coleoptera: Curculionidae), S. J. Erney, K. P. Pruess, S. D. Danielson, T. O. Powers

Department of Entomology: Faculty Publications

Mitochondrial DNA was amplified and sequenced from eastern, western, and Egyptian strains of alfalfa weevil, Hypera postica (Gyllenhal). Eastern and Egyptian weevils differed at only 2 nucleotide sites in 1,031 base pairs sequenced; western weevils differed by 5% sequence divergence. Three restriction sites were identified which separated eastern and western haplotypes. No intrastrain polymorphism was detected in 150 weevils from Nebraska. Collections from Lincoln in eastern Nebraska and Scottsbluff in western Nebraska were fixed for the eastern and western haplotypes, respectively. Eastern and western haplotypes were found together in the same fields in a broad overlap region in central Nebraska.

Microevolutionary Patterns And Molecular Markers: The Genetics Of Geographic Variation In Ascaris Suum, Steven A. Nadler

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Molecular markers have been used only rarely to characterize the population genetic structure of nematodes. Published studies have suggested that different taxa may show distinct genetic architectures. Isoenzyme and RAPD markers have been used to investigate geographic variation of Ascaris suum at the level of infrapopulations (nematodes within individual hosts), within localities, and among geographic regions. Independent estimates of genetic differentiation among population samples based on isoenzyme and RAPD data showed similar patterns and substantial correlation. Heterozygote deficiencies within infrapopulations and large values for inbreeding coefficients among infrapopulations suggested that the composition of these populations was not consistent with a …

Law And Ignorance: Genetic Therapy And The Legal Process, Roger B. Dworkin

Articles by Maurer Faculty

No abstract provided.

Numerical Chromosome Abnormalities In Sperm From Oligoasthenoteratozoospermic Patients And Fertile Males, Myung-Geol Pang

Theses and Dissertations in Biomedical Sciences

Artificial fertilization protocols have been developed which bypass natural barriers for reproduction. One aspect of infertility which has received little attention is the potential importance of aneuploidy in sperm. To more clearly understand the cytogenetic make-up of sperm from OAT patients, multi-probe, multi-color FISH was performed to determine aneuploidy.

The introduction of intracytoplasmic sperm injection (ICSI) has revolutionized protocols used in in vitro fertilization centers. The pregnancies resulting from ICSI suggest an increased frequency of sex chromosome aneuploidy in livebirths. Preliminary data by others' suggest that sperm tail swelling patterns following hypo-osmotic swelling (HOST) can be predictive of fertilizing ability. …

A Review Of Ministerial Policy Guidelines For Rock Lobster Processing In Western Australia From The Working Group Appointed By The Minister For Fisheries And Chaired By Peter Rich, Peter Rich

Fisheries Management Papers

The rock lobster processing industry in Western Australia has a long history of management. Whilst management of the industry through the Fisheries Department has obviously been successful in helping to build the rock lobster industry into one of the State's major export industries, this approach is not without problems. With the introduction of the Fisheries Management Act 1994, the Minister for Fisheries deemed it appropriate to appoint an expert group to review the existing regulation of the rock lobster processing sector, draft the necessary guidelines to assist the Executive Director of the Fisheries Department make decisions on rock lobster processing …

Active Inhibition Of T Cell Proliferation By Monocytes, Dean Anthony Lee

Loma Linda University Electronic Theses, Dissertations & Projects

Monoclonal antibodies (mAb) to MHC class II molecules (anti-class II mAb) have been well described in their ability to inhibit T cell activation. The most current model is that anti-class II mAb interfere directly with the T cell receptor-major histocompatibility complex crosslinking which is necessary for T cell activation. The anti-CD3 mAb, OKT3, is an MHC class II molecule-independent mitogen which causes T cell activation by direct ligation of the TCR-CD3 complex. OKT3 and a panel of anti-class II mAb were used to dissect the individual roles played by these two receptors in activation and inhibition of peripheral blood mononuclear …

Connexin32 Is A Myelin-Related Protein In The Pns And Cns, Steven S. Scherer, Suzanne M. Deschênes, Yi-Tian Xu, Judith B. Grinspan, Kenneth H. Fischbeck, David L. Paul

Biology Faculty Publications

We have examined the expression of a gap junction protein, connexin32 (Cx32), in Schwann cells and oligodendrocytes. In peripheral nerve, Cx32 is found in the paranodal myelin loops and Schmidt-Lanterman incisures of myelinating Schwann cells, and the levels of Cx32 protein and mRNA change in parallel with those of other myelin-related genes during development, Wallerian degeneration, and axonal regeneration. In the central nervous system, Cx32 is found in oligodendrocytes and their processes, but not in compact myelin, and the levels of Cx32 protein and mRNA increase during development in parallel with those of the other myelin genes. Thus, Cx32 is …

The Impact Of The New Management Package On Smaller Operators In The Western Rock Lobster Fishery, Ross Gould

Fisheries Management Papers

For the 1993/94 western rock lobster fishing season several new management strategies were introduced. The objective of the changes to the management package was to protect the rock lobster fishery. It was also to provide sufficient breeding stock to ensure viability of the industry. The most significant new measure was a temporary (two seasons) 18 percent pot reduction. Other changes were also made. There were considered sound reasons for reviewing and changing the previous management package. Despite this, some fishermen were critical of the new management package, and claimed that it unfairly disadvantaged smaller operators. Against this background, the Department …

Involvement Of P59FynT In Interleukin-5 Receptor Signaling, Mark W. Appleby, James D. Kerner, Sylvia Chien, Charles R. Maliszewski, Subbarao Bondada, Roger M. Perlmutter

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Previous studies implicate the nonreceptor protein tyrosine kinase (PTK) p59fyn in the propagation of signals from the B cell antigen receptor. To elucidate the functions of this kinase, we examined B cell responsiveness in mice engineered to lack the hematopoietic isoform of p59fyn. Remarkably, antigen receptor signaling was only modestly defective in fyn^Tnull B cells. In contrast, signaling from the interleukin (IL)-5 receptor which ordinarily provides a comitogenic stimulus with antiimmunoglobulin, was completely blocked. Our results document the importance of p59fyn^T in IL-5 responses in B cells, and they support a general model …

West Coast Rock Lobster Fishery Management Plan 1995 - Draft For Public Comment, M. Moran

Fisheries Management Papers

The purpose of this management plan is to regulate fishing for rock lobsters (Family Palimuridae) in waters off the west coast of Western Australia such that the breeding stock of rock lobsters is maintained at a level known to have generated adequate recruitment of young lobsters in the past. This management plan does not constitute a change in the management arrangements for the rock lobster fishery. It essentially replaces the West Coast Rock Lobster Limited Entry Fishery Notice 1993 made under the Fisheries Act 1905 and makes the required changes to wording and structure necessitated by the proclamation of the …

Bag And Size Limit Fishing Regulations From Around Australia - Current Information As At 1 July, 1995 - Third Australasian Fisheries Managers Conference, Rottnest Island, Wa, F. B. Prokop

Fisheries Management Papers

This paper was originally prepared for the first National Fisheries Managers Conference in 1993. It is now updated and includes the current bag and size limits from around Australia as at 1 July, 1995. It is fairly obvious from this paper that there is a need for more cooperation between the states, particularly for species which have wide distributions. However, regional solutions can be a good approach for specific management needs, while general rules can be made more consistent in a number of cases.

Developmental Regulation Of The Murine Cd4 Gene, Rhonda Kay Hansen

Loma Linda University Electronic Theses, Dissertations & Projects

CD4 is a membrane bound glycoprotein that plays an important role in T cell development and activation. An extensive analysis of the CD4 locus identified potential transcriptional control elements located 5' of the promoter and within the first intron. Since the molecular mechanism for the control of CD4 expression during T cell development had not been determined, it is the focus of this dissertation. A series of recombinant DNA constructs were made to determine the contribution of putative transcriptional control elements in regard to CD4 expression, and to identify elements being used to control CD4 expression during T cell development. …