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2018

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Articles 2161 - 2190 of 3206

Full-Text Articles in Biology

Diet Induced Obesity Alters Muscle Spindle Afferent Function In Adult Mice, Lubayna Elahi, Krystle Shamai, Adam Abtahie, Adam Cai, Shreejit Padmanabhan, Martina Bremer, Katherine A. Wilkinson May 2018

Diet Induced Obesity Alters Muscle Spindle Afferent Function In Adult Mice, Lubayna Elahi, Krystle Shamai, Adam Abtahie, Adam Cai, Shreejit Padmanabhan, Martina Bremer, Katherine A. Wilkinson

Faculty Publications, Biological Sciences

Populations with obesity are more likely to fall and exhibit balance instability. The reason for this is likely multifactorial, but there is some evidence that sensory function is impaired during obesity. We tested the hypothesis that muscle proprioceptor function is compromised in a mouse model of diet induced obesity. An in vitro muscle-nerve preparation was used to record muscle spindle afferent responses to physiological stretch and sinusoidal vibration. We compared the responses of C57/Bl6 male and female mice on a control diet (10% kcal fat) with those eating a high fat diet (HFD; 60% kcal fat) for 10 weeks (final …

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Landscape Genetics Of Ambystoma Opacum In Mammoth Cave National Park, Haley Austin May 2018

Landscape Genetics Of Ambystoma Opacum In Mammoth Cave National Park, Haley Austin

Mahurin Honors College Capstone Experience/Thesis Projects

No abstract provided.

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Preliminary Work On Infestation Dynamics And Stable Isotope Ecology Of A Coral Reef Micropredator, William Garrett Jenkins May 2018

Preliminary Work On Infestation Dynamics And Stable Isotope Ecology Of A Coral Reef Micropredator, William Garrett Jenkins

Student Theses and Dissertations

Despite the significant ecological role that parasites likely play within their respective communities, little is understood about the role that they play within food webs. The studies presented herein sought to expand upon the understanding of the role that gnathiid isopods, a marine fish ectoparasite, play within coral reef ecological communities by: a) assessing the effect of host physical condition on susceptibility to exploitation by a gnathiid isopod and b) by conducting a comprehensive, preliminary, study on the stable isotope ecology of these micropredators. Host fish which were experimentally injured during field trials exhibited a higher probability of being parasitized …

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Evolution Of Voltage-Gated Ion Channels, Kevin Gregory Bennett, Kevin Bennett May 2018

Evolution Of Voltage-Gated Ion Channels, Kevin Gregory Bennett, Kevin Bennett

Master of Science in Integrative Biology Theses

Voltage-gated Ion Channels (VICs) form a superfamily of energy-independent membrane transporters that facilitate the transfer of charged sodium, calcium, and potassium ions across the cell membrane (Hodgkin & Huxley 1952). The channels contain a selective ion-conducting pore along with several other structural and gating features that come together to form a functional hetero- or homotetramer. A comprehensive phylogenetic study of all available proteins aimed at finding unknown distribution and illuminating evolutionary paths would be immensely useful in understanding relationships of structure, function, and organismal distribution. This phylogenetic analysis of VICs will be immensely useful in characterizing functional and structural distribution, …

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Pyruvate Kinase Isoform M2 Influences Autophagy And Related Processes In Hepatocellular Carcinoma Cells, Matthew Lin May 2018

Pyruvate Kinase Isoform M2 Influences Autophagy And Related Processes In Hepatocellular Carcinoma Cells, Matthew Lin

University Scholar Projects

Hepatocellular carcinoma (HCC) is the most common form of liver cancer that affects ~14 million people in the world. Like all cancers, HCC is a disease that arises from unstinted cellular growth initiated by genetic alterations, metabolic changes, and dysregulation in key cellular pathways. Of interest is the relationship between metabolism and cell proliferation/degradation for therapeutic targeting. Pyruvate kinase M2 is a dimeric, glycolytically inactive isoform of the final enzyme involved in glycolysis, that is often upregulated in cancerous tissue. It is thought that the enzymatic function of PKM2 outside of glycolysis contributes to the biosynthesis of anabolic intermediates used …

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Functional Studies Of The E. Coli Proc And A Putative Ortholog Mrub_1345, Maureen Azar, Dr. Lori Scott May 2018

Functional Studies Of The E. Coli Proc And A Putative Ortholog Mrub_1345, Maureen Azar, Dr. Lori Scott

Meiothermus ruber Genome Analysis Project

This project is part of the Meiothermus ruber genome analysis project, which uses the bioinformatics tools associated with the Guiding Education through Novel Investigation –Annotation Collaboration Toolkit (GENI-ACT) to predict gene function. We investigated the biological function of Escherichia coli and Meiothermus ruber proC genes using the complementation assay. In this research project, mutants of varying severity to the functional state of the protein were developed. The results showed that two or more amino acid deletions reduced or eliminated ProC function. Amino acid substitutions, on the other hand, were not severe enough to impact ProC function. Double and triple mutants …

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Hormonebase, A Population-Level Database Of Steroid Hormone Levels Across Vertebrates, Maren N. Vitousek, Michele A. Johnson, Jeremy W. Donald, C. D. Francis, M. J. Fuxjager, W. Goymann, M. Hau, Jerry F. Husak, Bonnie K. Kircher, R. Knapp, L. B. Martin, E. T. Miller, L. A. Schoenle, J. J. Uehling, T. D. Williams May 2018

Hormonebase, A Population-Level Database Of Steroid Hormone Levels Across Vertebrates, Maren N. Vitousek, Michele A. Johnson, Jeremy W. Donald, C. D. Francis, M. J. Fuxjager, W. Goymann, M. Hau, Jerry F. Husak, Bonnie K. Kircher, R. Knapp, L. B. Martin, E. T. Miller, L. A. Schoenle, J. J. Uehling, T. D. Williams

Biology Faculty Research

Hormones are central regulators of organismal function and flexibility that mediate a diversity of phenotypic traits from early development through senescence. Yet despite these important roles, basic questions about how and why hormone systems vary within and across species remain unanswered. Here we describe HormoneBase, a database of circulating steroid hormone levels and their variation across vertebrates. This database aims to provide all available data on the mean, variation, and range of plasma glucocorticoids (both baseline and stress-induced) and androgens in free-living and un-manipulated adult vertebrates. HormoneBase (www.HormoneBase.org) currently includes >6,580 entries from 476 species, reported in 648 publications from …

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Do Seasonal Glucocorticoid Changes Depend On Reproductive Investment? A Comparative Approach In Birds, S. Casagrande, L. Z. Garamszegi, W. Goymann, Jeremy W. Donald, C. D. Francis, M. J. Fuxjager, Jerry F. Husak, Michele A. Johnson, Bonnie K. Kircher, R. Knapp, L. B. Martin, E. T. Miller, L. A. Schoenle, Maren N. Vitousek, T. D. Williams, M. Hau May 2018

Do Seasonal Glucocorticoid Changes Depend On Reproductive Investment? A Comparative Approach In Birds, S. Casagrande, L. Z. Garamszegi, W. Goymann, Jeremy W. Donald, C. D. Francis, M. J. Fuxjager, Jerry F. Husak, Michele A. Johnson, Bonnie K. Kircher, R. Knapp, L. B. Martin, E. T. Miller, L. A. Schoenle, Maren N. Vitousek, T. D. Williams, M. Hau

Biology Faculty Research

Animals go through different life history stages such as reproduction, moult, or migration, of which some are more energy-demanding than others. Baseline concentrations of glucocorticoid hormones increase during moderate, predictable challenges and thus are expected to be higher when seasonal energy demands increase, such as during reproduction. By contrast, stress-induced glucocorticoids prioritize a survival mode that includes reproductive inhibition. Thus, many species down-regulate stress-induced glucocorticoid concentrations during the breeding season. Interspecific variation in glucocorticoid levels during reproduction has been successfully mapped onto reproductive investment, with species investing strongly in current reproduction (fast pace of life) showing higher baseline and lower …

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Sympatric Serpentine Endemic Monardella (Lamiaceae) Species Maintain Habitat Differences Despite Hybridization, Kathleen M. Kay, Suzie Woolhouse, Brett A. Smith, Nathaniel S. Pope, Nishanta Rajakaruna May 2018

Sympatric Serpentine Endemic Monardella (Lamiaceae) Species Maintain Habitat Differences Despite Hybridization, Kathleen M. Kay, Suzie Woolhouse, Brett A. Smith, Nathaniel S. Pope, Nishanta Rajakaruna

Biological Sciences

Ecological differentiation and genetic isolation are thought to be critical in facilitating coexistence between related species, but the relative importance of these phenomena and the interactions between them are not well understood. Here, we examine divergence in abiotic habitat affinity and the extent of hybridization and introgression between two rare species of Monardella (Lamiaceae) that are both restricted to the same serpentine soil exposure in California. Although broadly sympatric, they are found in microhabitats that differ consistently in soil chemistry, slope, rockiness and vegetation. We identify one active hybrid zone at a site with intermediate soil and above-ground characteristics, and …

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Diversity And Functional Traits Of Lichens In Ultramafic Areas: A Literature Based Worldwide Analysis Integrated By Field Data At The Regional Scale, Sergio E. Favero-Longo, Enrica Matteucci, Paolo Giordani, Alexander G. Paukov, Nishanta Rajakaruna May 2018

Diversity And Functional Traits Of Lichens In Ultramafic Areas: A Literature Based Worldwide Analysis Integrated By Field Data At The Regional Scale, Sergio E. Favero-Longo, Enrica Matteucci, Paolo Giordani, Alexander G. Paukov, Nishanta Rajakaruna

Biological Sciences

While higher plant communities found on ultramafics are known to display peculiar characteristics, the distinguishability of any peculiarity in lichen communities is still a matter of contention. Other biotic or abiotic factors, rather than substrate chemistry, may contribute to differences in species composition reported for lichens on adjacent ultramafic and non-ultramafic areas. This work examines the lichen biota of ultramafics, at global and regional scales, with reference to species-specific functional traits. An updated world list of lichens on ultramafic substrates was analyzed to verify potential relationships between diversity and functional traits of lichens in different Köppen–Geiger climate zones. Moreover, a …

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Biological Crusts Of Serpentine And Non-Serpentine Soils From The Barberton Greenstone Belt Of South Africa, Arthurita Venter, Stefan Siebert, Nishanta Rajakaruna, Sandra Barnard, Anatoliy Levanets, Arshad Ismail, Mushal Allam, Bianca Peterson, Tomasz Sanko May 2018

Biological Crusts Of Serpentine And Non-Serpentine Soils From The Barberton Greenstone Belt Of South Africa, Arthurita Venter, Stefan Siebert, Nishanta Rajakaruna, Sandra Barnard, Anatoliy Levanets, Arshad Ismail, Mushal Allam, Bianca Peterson, Tomasz Sanko

Biological Sciences

Climate and geography can influence biological soil crust (BSC) community composition, but local heterogeneity in variables such as soil characteristics or microclimate gradients can also impact cryptogamic diversity. Heavy metals and nutrient imbalances in serpentine soils are known to influence the distributions of higher plants, but cryptogamic species appear to be more tolerant of substrate. The aim of this study was to compare the cryptogamic composition of serpentine and non-serpentine soils by using integrative taxonomy, which combines morphological and DNA barcoding data, to determine how soil characteristics in combination with rainfall can influence BSC community composition. Samples from serpentine and …

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A Time Course Study Of Rotavirus-Infected Intestinal Cells Treated With Stilbenoids And The Regulation Of Apoptosis, Rebecca D. Parr, Caleb M. Witcher, Rebekah Napier-Jameson, Hannah L. Wilson, Stormey Wisdom, Macie N. Mattila, Essence B. Strange, Josephine Taylor, Beatrice Clack, Fabricio Medina-Bolivar, Judith M. Ball May 2018

A Time Course Study Of Rotavirus-Infected Intestinal Cells Treated With Stilbenoids And The Regulation Of Apoptosis, Rebecca D. Parr, Caleb M. Witcher, Rebekah Napier-Jameson, Hannah L. Wilson, Stormey Wisdom, Macie N. Mattila, Essence B. Strange, Josephine Taylor, Beatrice Clack, Fabricio Medina-Bolivar, Judith M. Ball

Faculty Publications

This is a time course study of virus –host interactions that are modified with the addition of two small natural products. They appear to effect virus replication and the host response to the infection.

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Senecio Conrathii N.E.Br. (Asteraceae), A New Hyperaccumulator Of Nickel From Serpentinite Outcrops Of The Barberton Greenstone Belt, South Africa, Stefan Siebert, Nadine Carol Schutte, Stoffel Pieter Bester, Dennis Mmakgabo Komape, Nishanta Rajakaruna May 2018

Senecio Conrathii N.E.Br. (Asteraceae), A New Hyperaccumulator Of Nickel From Serpentinite Outcrops Of The Barberton Greenstone Belt, South Africa, Stefan Siebert, Nadine Carol Schutte, Stoffel Pieter Bester, Dennis Mmakgabo Komape, Nishanta Rajakaruna

Biological Sciences

Five nickel hyperaccumulators belonging to the Asteraceae are known from ultramafic outcrops in South Africa. Phytoremediation applications of the known hyperaccumulators in the Asteraceae, such as the indigenous Berkheya coddii Roessler, are well reported and necessitate further exploration to find additional species with such traits. This study targeted the most frequently occurring species of the Asteraceae on eight randomly selected serpentinite outcrops of the Barberton Greenstone Belt. Twenty species were sampled, including 12 that were tested for nickel accumulation for the first time. Although the majority of the species were excluders, the known hyperaccumulators Berkheya nivea N.E.Br. and B. zeyheri …

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A Global Forum On Ultramafic Ecosystems: From Ultramafic Ecology To Rehabilitation Of Degraded Environments, Guillaume Echevarria, Alan J. M. Baker, Robert S. Boyd, Antony Van Der Ent, Takafumi Mizuno, Nishanta Rajakaruna, Shota Sakaguchi, Aida Bani May 2018

A Global Forum On Ultramafic Ecosystems: From Ultramafic Ecology To Rehabilitation Of Degraded Environments, Guillaume Echevarria, Alan J. M. Baker, Robert S. Boyd, Antony Van Der Ent, Takafumi Mizuno, Nishanta Rajakaruna, Shota Sakaguchi, Aida Bani

Biological Sciences

The 9th International Conference on Serpentine Ecology (ICSE) was held in Tirana and Pogradec (Albania) from June 5 to 9, 2017. More than 100 delegates from 29 countries around the world gathered to present their research on recent advances in: (i) ultramafic soils, (ii) biogeochemistry, (iii) diversity of ultramafic flora, microflora and fauna, (iv) ecophysiology of ultramafic-adapted organisms, (v) interactions between ultramafic organisms and their ecology, (vi) nature rehabilitation of degraded ultramafic environments (resulting from mining activities), and (vii) the production of bio-based metals through agromining technology. Additionally, the ICSE featured the first symposium on ultramafic aquatic ecology and ecotoxicology. …

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Ultramafic Vegetation And Soils In The Circumboreal Region Of The Northern Hemisphere, Anzhelika Teptina May 2018

Ultramafic Vegetation And Soils In The Circumboreal Region Of The Northern Hemisphere, Anzhelika Teptina

Biological Sciences

The paper summarizes literature on climate, soil chemistry, vegetation and metal accumulation by plants found on ultramafic substrata in the circumboreal zone (sensu Takhtajan, Floristic regions of the world, 1986) of the Northern Hemisphere. We present a list of 50 endemic species and 18 ecotypes obligate to ultramafic soils from the circumboreal region of Holarctic, as well as 30 and 2 species of Ni and Zn hyperaccumulators, respectively. The number of both endemics and hyperaccumulators are markedly lower compared to that of the Mediterranean and tropical regions. The diversity of plant communities on ultramafics soils of the circumboral region is …

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Western Australian Sea Cucumber Resource - Harvest Strategy 2018-2023, Department Of Primary Industries And Regional Development May 2018

Western Australian Sea Cucumber Resource - Harvest Strategy 2018-2023, Department Of Primary Industries And Regional Development

Fisheries Management Papers

This publication of harvest strategies is intended to make the decision-making considerations and processes for the management of specified aquatic resources publicly transparent and provide a basis for informed dialogue on management actions with resource users and other stakeholders.

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Draft Management Plan For The Kimberley Crab Managed Fishery, Department Of Fisheries May 2018

Draft Management Plan For The Kimberley Crab Managed Fishery, Department Of Fisheries

Fisheries Management Papers

No abstract provided.

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Draft Management Plan For The Pilbara Crab Managed Fishery, Department Of Fisheries May 2018

Draft Management Plan For The Pilbara Crab Managed Fishery, Department Of Fisheries

Fisheries Management Papers

No abstract provided.

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The Molecular Chaperone Hsp90 Promotes Notch Signaling In The Germline Of Caenorhabditis Elegans, James L. Lissemore, Elyse Connors, Ying Liu, Li Qiao, Bing Yang, Mark L. Edgley, Stephane Flibotte, Jon Taylor, Vinci Au, Donald G. Moerman, Eleanor M. Maine May 2018

The Molecular Chaperone Hsp90 Promotes Notch Signaling In The Germline Of Caenorhabditis Elegans, James L. Lissemore, Elyse Connors, Ying Liu, Li Qiao, Bing Yang, Mark L. Edgley, Stephane Flibotte, Jon Taylor, Vinci Au, Donald G. Moerman, Eleanor M. Maine

2018 Faculty Bibliography

In a genetic screen to identify genes that promote GLP-1/Notch signaling in Caenorhabditis elegans germline stem cells, we found a single mutation, om40, defining a gene called ego-3. ego-3(om40) causes several defects in the soma and the germline, including paralysis during larval development, sterility, delayed proliferation of germline stem cells, and ectopic germline stem cell proliferation. Whole genome sequencing identified om40 as an allele of hsp-90, previously known as daf-21, which encodes the C. elegans ortholog of the cytosolic form of HSP90. This protein is a molecular chaperone with a central position in the protein homeostasis network, which is responsible …

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Population Characteristics Of A Closed Northern Pike (Esox Lucius) Catch-And-Release Population In Minnesota, John Kempe May 2018

Population Characteristics Of A Closed Northern Pike (Esox Lucius) Catch-And-Release Population In Minnesota, John Kempe

Biology Graduate Theses

Literature regarding catch-and-release populations of Northern Pike are rare and provide a unique perspective on their population dynamics. Shingobee Lake is a 64- ha mesotrophic lake with a maximum depth of 12.2 m located in northern Minnesota. Northern Pike fishing has been catch-and-release only since 2005, and there are no public accesses on the lake. Annual ice-out trap-netting occurred from 2009-2017, and a sizable amount of the Northern Pike recaptured via trapnet or angling had been previously tagged (37-59%). The lack of exploitation and high tagging percentage provided a unique opportunity to study the population dynamics of Northern Pike. Shinogbee’s …

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Analyzing The Effects Of Site-Directed Mutagenesis On The Structure Of Coxsackievirus B3 Genomic Rna, Erin Dimon May 2018

Analyzing The Effects Of Site-Directed Mutagenesis On The Structure Of Coxsackievirus B3 Genomic Rna, Erin Dimon

Theses/Capstones/Creative Projects

Coxsackievirus B3 (CVB3) is known to cause myocarditis and pancreatitis in humans. The virus has a single stranded RNA genome that codes for 11 different proteins. CVB3 is found to have two serotypes: 28 (virulent and disease causing) and GA (avirulent and not disease causing). Like other members of the Picornaviridae family, CVB3 utilizes the genomic 5’ untranslated region (5’ UTR) to initiate viral replication mechanisms through interactions with host protein factors. Structural variations of the CVB3 5’ UTR are hypothesized to influence the success of such interactions and consequentially determine viral virulence. The aim of this project was to …

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Female Preference For Male Calls Produced At Higher Temperatures In Metrioptera Roeselii (Orthoptera: Tettigoniidae), Alexandra Logan May 2018

Female Preference For Male Calls Produced At Higher Temperatures In Metrioptera Roeselii (Orthoptera: Tettigoniidae), Alexandra Logan

Renée Crown University Honors Thesis Projects - All

Male advertisement signals and female preference are directly affected by ambient temperatures in many exothermic species. Previous studies indicate that male Metrioptera roeselii increase their buzz duration and vary other call parameters with increasing temperature. This study examines female M. roeselii responses to the playback of male calls to determine if they show variation in preference for calls produced at different temperatures. Comparing the strength of female response to male calls produced at higher temperatures with calls produced at lower temperatures may provide insight into the factors that affect the perceived quality of a male signal. To examine this, I …

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Decreased Brood-Size Of Starvation-Induced Postdauer Adults Is Inherited Transgenerationally Via Hrde-1, Ibnul Rafi May 2018

Decreased Brood-Size Of Starvation-Induced Postdauer Adults Is Inherited Transgenerationally Via Hrde-1, Ibnul Rafi

Renée Crown University Honors Thesis Projects - All

Environmental stress experienced in utero or in early life has profound effects on the behavior and physiology of an adult animal. Interestingly, genome-wide association studies in humans have shown that early-life stress not only affects the exposed individual, but also their future generations. However, the molecular mechanisms of how early-life stress can impact physiology transgenerationally in the absence of the original stress are not well understood. To study the mechanisms and consequences of environmental stress on adult phenotypes, we utilize the life cycle of the model organism Caenorhabditis elegans. In favorable conditions, the life cycle of C. elegans includes 5 …

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Rattlesnake Genomics Illustrate Patterns Of Speciation, Adaptation, And Links Between Genome Structure And Function, Drew Roberts Schield May 2018

Rattlesnake Genomics Illustrate Patterns Of Speciation, Adaptation, And Links Between Genome Structure And Function, Drew Roberts Schield

Biology Dissertations - Archive

Understanding the origins of species and biological novelties that allow them to thrive in diverse environments is a key goal in evolutionary biology, and new genomic methods are constantly enabling research using non-model species to address important questions related to speciation and adaptation. Using phylogeographic, population genetic, and comparative genomic methods, I demonstrate that North American rattlesnakes are a uniquely enriched system for investigating patterns and processes at the intersection of adaptation and speciation. Specifically, this dissertation explores the evolution of biological novelty at multiple scales, including the origins of reproductive incompatibilities during the process of gene flow in secondary …

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Maternal Vitamin D Deficiency And Early Childhood Health Outcomes Including Autism Development, Kelsey L. Girardelli May 2018

Maternal Vitamin D Deficiency And Early Childhood Health Outcomes Including Autism Development, Kelsey L. Girardelli

Undergraduate Honors Capstone Projects

Many studies have shown that vitamin D deficiency during pregnancy is associated with a variety of adverse maternal and pediatric outcomes. Disease outcomes that have been observed in pregnant women who are vitamin D deficient include increased risk of C-section, preeclampsia, bacterial vaginosis, and gestational diabetes. In children born to deficient mothers, increased rates of childhood asthma, type 1 diabetes, low birthweight, and autism spectrum disorder (ASD) have been observed. Although there is much evidence to support these correlations, much is yet to be understood regarding the etiology of these outcomes. This paper specifically examines the relationships between risk factors …

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Evaluation Of Antiviral Agents In Two Mouse Models Of Rna Virus Infections, John Hyrum Mcclatchy May 2018

Evaluation Of Antiviral Agents In Two Mouse Models Of Rna Virus Infections, John Hyrum Mcclatchy

Undergraduate Honors Capstone Projects

The first model we are evaluating is human influenza virus in mice. Influenza virus is a negative sense RNA virus, which the CDC estimates causes between 9.2 million and 35.6 million illnesses each year in the United States.[1] In the current influenza season, H3N2 viruses have been the predominant subclade of influenza A virus in circulation.[2] Development of a mouse model for influenza H3N2 virus infection has been difficult. In these studies, we endeavored to mouse-adapt influenza A/Hong Kong/4801/2014 H3N2 virus by serial passaging in AG129 mice. This virus strain was chosen as it overlaps in serotype with …

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The Effect Of Gender And Socioeconomic Status On Concussion Reporting Behavior Among Ncaa Student-Athletes, Joshua Anthony Hansen May 2018

The Effect Of Gender And Socioeconomic Status On Concussion Reporting Behavior Among Ncaa Student-Athletes, Joshua Anthony Hansen

Undergraduate Honors Capstone Projects

Concussions are traumatic brain injuries that result from "brain shaking" that can occur during any situation that transmits force to the head. Concussions are defined as a clinical syndrome characterized by immediate and transient post-traumatic impairment of neural functions which lead to a complex grouping of both psychological and physiological symptoms (McCrory, et al., 2013). As knowledge of the long-term implications of these injuries grows, concussions are becoming more of a major health concern worldwide. One subset of concussion classifications, sports-related concussions, is receiving an increasing amount of attention from both scientists and health-care practitioners. It is estimated that more …

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Role Of Leptin And Dyslipidemia In Chronic Kidney Disease, Sabeela Noor, Faiza Alam, Syeda Sadia Fatima, Mahnur Khan, Rehana Rehman May 2018

Role Of Leptin And Dyslipidemia In Chronic Kidney Disease, Sabeela Noor, Faiza Alam, Syeda Sadia Fatima, Mahnur Khan, Rehana Rehman

Department of Biological & Biomedical Sciences

Chronic kidney disease (CKD) patients are at an increased risk of cardiovascular complications and plasma leptin level is elevated in cardio renal syndrome. We wanted to explore leptin levels in patients with different stages of CKD and find its association with risk of cardiovascular disease. This cross-sectional study was conducted in Nephrology Department of Jinnah Post Graduate Medical Centre (JPMC) from January 2014 to September 2014. Group I comprised of controls (GFR=116±8.3, n = 44) acquired from general population, CKD patients were grouped as II, III and IV respectively with GFR; 85.77±9.9 (n = 42), 53.84±9.9 (n=42) and 20.22±8.4 (n …

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Disease In A Changing Ocean: Ecoimmunological Approaches To Coral Reef Ecology, Lauren Elizabeth Fuess May 2018

Disease In A Changing Ocean: Ecoimmunological Approaches To Coral Reef Ecology, Lauren Elizabeth Fuess

Biology Dissertations - Archive

Increasing prevalence of anthropogenic stressors and climate change have resulted in rapid increases in the incidence and severity marine disease affecting a number of vulnerable taxa. Cnidarians, including both reef-building (scelaractinian) and other species of corals, have been among those taxa most affected by these increases. The rise of wildlife epizootic outbreaks, both in the oceans and in terrestrial ecosystems, has resulted in equal increases of studies of ecoimmunology. Research in these areas aims to understand how variation in disease susceptibility and immune response affect the ecology of vulnerable communities. Here I employ a variety of ecoimmunological approaches to study …

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Specimen Accountability Process Change In A Non-Automated Consolidated Microbiology Laboratory, Michael Monh May 2018

Specimen Accountability Process Change In A Non-Automated Consolidated Microbiology Laboratory, Michael Monh

Dissertations, Masters Theses, Capstones, and Culminating Projects

The pre-analytical phase contributes 60-70% of total error of the total testing process (TTP) (Plebani 2006). The pre-analytical phase can be further divided into two phases; the ‘pre-preanalytical’ and ‘preanalytical’ phases, which commonly includes tasks performed outside of the laboratory walls, and tasks perform within the laboratory’s walls and control, respectively. Additionally, medical care reimbursement policies in the U.S. along with the need to efficiently produce quality results and reduce the costs to clients, has caused the microbiology lab to move from on-site to more resourcefully abundant consolidate labs (Sautter 2014). Serving many satellite facilities, it is of interest to …

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