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2006

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Articles 391 - 420 of 536

Full-Text Articles in Biology

Identification Of A Family Of Bsp-A Like Surface Proteins Of Entamoeba Histolytica With Novel Leucine Rich Repeats., Paul H. Davis, Zhi Zhang, Minghe Chen, Xiaochun Zhang, Subhra Chakraborty, Samuel L. Stanley Jr. Jan 2006

Identification Of A Family Of Bsp-A Like Surface Proteins Of Entamoeba Histolytica With Novel Leucine Rich Repeats., Paul H. Davis, Zhi Zhang, Minghe Chen, Xiaochun Zhang, Subhra Chakraborty, Samuel L. Stanley Jr.

Biology Faculty Publications

Leucine rich repeats serve as recognition motifs for surface proteins from bacteria and eukaryotes. The BspA protein from Bacteroides forsythus mediates bacterial binding to fibronectin and contains leucine rich repeats of the Treponema pallidum (TpLRRP) family. Here we show that the protozoan parasite Entamoeba histolytica contains multiple BspA-like proteins, including a family of surface proteins which possess a new form of a leucine rich repeat that differs from the standard Treponema pallidum- like leucine rich repeat (TpLRRP) by possessing two conserved cysteine residues.

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The Development And Structure Of Feeding Arms In Antarctic Species Of Pterobranchs (Pterobranchia, Hemichordata), Catherine Krahe '06 Jan 2006

The Development And Structure Of Feeding Arms In Antarctic Species Of Pterobranchs (Pterobranchia, Hemichordata), Catherine Krahe '06

Honors Projects

Pterobranchs are of particular interest to evolutionary biologists because as members of the phylum Hemichordata, they share characteristics with vertebrate animals and other chordates. The focus of this study is an examination of the development, structure, and function of the feeding arms in several species of pterobranchs collected from depths greater than 500 m from waters surrounding Antarctica. Pterobranch zooids in the genus Cephalodiscus feed using a crown of arms held over the dorsal surface of the body to filter particles from the water. Larvae released from adult tubes are ciliated, but lack feeding arms and are thought to derive …

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Establishment Of Polarity During Organization Of The Acentrosomal Plant Cortical Microtubule Array, Ram Dixit, Eric Chang, Richard Cyr Jan 2006

Establishment Of Polarity During Organization Of The Acentrosomal Plant Cortical Microtubule Array, Ram Dixit, Eric Chang, Richard Cyr

Biology Faculty Research

The plant cortical microtubule array is a unique acentrosomal array that is essential for plant morphogenesis. To understand how this array is organized, we exploited the microtubule (+)-end tracking activity of two Arabidopsis EB1 proteins in combination with FRAP (fluorescence recovery after photobleaching) experiments of GFP-tubulin to examine the relationship between cortical microtubule array organization and polarity. Significantly, our observations show that the majority of cortical microtubules in ordered arrays, within a particular cell, face the same direction in both Arabidopsis plants and cultured tobacco cells. We determined that this polar microtubule coalignment is at least partially due to a …

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Case Studies Add Value To A Diverse Teaching Portfolio In Science Courses, Philip Camill Jan 2006

Case Studies Add Value To A Diverse Teaching Portfolio In Science Courses, Philip Camill

Biology Faculty Work

No abstract provided.

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Asymmetric Vegetation Responses To Mid-Holocene Aridity At The Prairie-Forest Ecotone In South-Central Minnesota, Charles Umbanhowar, Phil Camill, Christoph Geiss, Rebecca Teed Jan 2006

Asymmetric Vegetation Responses To Mid-Holocene Aridity At The Prairie-Forest Ecotone In South-Central Minnesota, Charles Umbanhowar, Phil Camill, Christoph Geiss, Rebecca Teed

Biology Faculty Work

The mid-Holocene (ca. 8000–4000 cal yr BP) was a time of marked aridity throughout much of Minnesota, and the changes due to midHolocene aridity are seen as an analog for future responses to global warming. In this study, we compare the transition into (ca. 9000–7000 yr ago) and out of (ca. 5000–2500 yr ago) the mid-Holocene (MH) period at Kimble Pond and Sharkey Lake, located along the prairie forest ecotone in south-central Minnesota, using high resolution (∼5–36 yr) sampling of pollen, charcoal, sediment magnetic and loss-on-ignition properties. Changes in vegetation were asymmetrical with increasing aridity being marked by a pronounced …

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The Flagellar Motility Of Chlamydomonas Pf25 Mutant Lacking An Akap-Binding Protein Is Overtly Sensitive To Medium Conditions, Chun Yang, Pinfen Yang Jan 2006

The Flagellar Motility Of Chlamydomonas Pf25 Mutant Lacking An Akap-Binding Protein Is Overtly Sensitive To Medium Conditions, Chun Yang, Pinfen Yang

Biological Sciences Faculty Research and Publications

Radial spokes are a conserved axonemal structural complex postulated to regulate the motility of 9 + 2 cilia and flagella via a network of phosphoenzymes and regulatory proteins. Consistently, a Chlamydomonas radial spoke protein, RSP3, has been identified by RII overlays as an A-kinase anchoring protein (AKAP) that localizes the cAMP-dependent protein kinase (PKA) holoenzyme by binding to the RIIa domain of PKA RII subunit. However, the highly conserved docking domain of PKA is also found in the N termini of several AKAP-binding proteins unrelated to PKA as well as a 24-kDa novel spoke protein, RSP11. Here, we report that …

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Tick Pheromones And Their Use In Tick Control, Daniel E. Sonenshine Jan 2006

Tick Pheromones And Their Use In Tick Control, Daniel E. Sonenshine

Biological Sciences Faculty Publications

Tick pheromones that regulate assembly, attraction/aggregation/attachment, and mating behavior have been described. Most of the compounds regulating these behaviors are purines, substituted phenols, or cholesteryl esters. Other pheromonal compounds include organic acids, hematin, or ecdysteroids. Novel devices have been developed that combine the specific compounds comprising these pheromones with an acaricide. When applied to tick-infested vegetation or directly to the body surfaces of livestock or companion animals, these devices are effective for tick control. This review summarizes the current state of knowledge of tick pheromones. In addition, this review also presents examples illustrating how devices using tick pheromones can offer …

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Patterns Of Habitat Use By Bats Along A Riparian Corridor In Northern Utah, Duke S. Rogers, Mark C. Belk, Malinda W. González, Brent L. Coleman Jan 2006

Patterns Of Habitat Use By Bats Along A Riparian Corridor In Northern Utah, Duke S. Rogers, Mark C. Belk, Malinda W. González, Brent L. Coleman

Faculty Publications

We examined patterns of habitat use within a community of bats along the Provo River in Heber Valley, Utah. The landscape was divided into 5 habitat categories: riparian forest, wetland, agricultural field, edge, and a habitat restoration site. We used Anabat II bat detectors to record the number of echolocation calls per night within each habitat type as an index of bat activity. Echolocation calls were classified into foraging guilds based on acoustic traits, and we analyzed activity by entire community and by the 4 guilds related to habitat type and environmental variables. Activity was not significantly related to moon …

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Habitat-Specific Impacts Of Multiple Consumers On Plant Population Dynamics, John L. Maron, Matthew J. Kauffman Jan 2006

Habitat-Specific Impacts Of Multiple Consumers On Plant Population Dynamics, John L. Maron, Matthew J. Kauffman

Biological Sciences Faculty Publications

Multiple consumers often attack seeds, seedlings, and adult plants, but their population-level consequences remain uncertain. We examined how insect and small mammal consumers influenced the demography and abundance of the perennial shrub, bush lupine (Lupinus arboreus). In grassland and dune habitats we established replicate experimental lupine populations in 81-m2 plots that were either protected from, or exposed to, herbivorous voles and granivorous mice (via fencing) and/or root feeding insects (via insecticide treatment). Populations were initiated with transplanted seedlings in 1999 and 2000. We followed the demography of these cohorts, subsequent generations, and the seed bank for 5.5 …

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From Mendel To Molecules: A Brief History Of Evolutionary Genetics, Michael Dietrich Jan 2006

From Mendel To Molecules: A Brief History Of Evolutionary Genetics, Michael Dietrich

Dartmouth Scholarship

No abstract provided.

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Integration Without Unification: An Argument For Pluralism In The Biological Sciences, Michael Dietrich, Sandra D. Mitchell Jan 2006

Integration Without Unification: An Argument For Pluralism In The Biological Sciences, Michael Dietrich, Sandra D. Mitchell

Dartmouth Scholarship

In this article, we consider the tension between unification and pluralism in biological theory. We begin with a consideration of historical efforts to establish a unified understanding of evolution in the neo-Darwinian synthesis. The fragmentation of the evolutionary synthesis by molecular evolution suggests the limitations of the general unificationist ideal for biology but not necessarily for integrating explanations. In the second half of this article, we defend a specific variety of pluralism that allows for the integration required for explanations of complex phenomena without unification on a large scale.

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Bogidiella Indica, A New Species Of Subterranean Amphipod Crustacean (Bogidiellidae) From Wells In Southeastern India, With Remarks On The Biogeographic Importance Of Recently Discovered Bogidiellids On The Indian Subcontinent, John R. Holsinger, Y. Ranga Reddy, Mohammed Messouli Jan 2006

Bogidiella Indica, A New Species Of Subterranean Amphipod Crustacean (Bogidiellidae) From Wells In Southeastern India, With Remarks On The Biogeographic Importance Of Recently Discovered Bogidiellids On The Indian Subcontinent, John R. Holsinger, Y. Ranga Reddy, Mohammed Messouli

Biological Sciences Faculty Publications

Bogidiella indica, new species, is described from three water wells in southeastern India, including a bore-well on the campus of Acharya Nagarjuna University in Nagarjunanagar, a water well in Guntur town, and an agricultural well in the Godavari and Krishna Basin, all in the state of Andhra Pradesh, India. The new species is assigned to the genus Bogidiella Hertzog and to a newly designated species group within the genus. Despite the near circum-global distribution of the family Bogidiellidae, only a single, partially intact specimen of a bogidiellid had been collected from the Indian subcontinent prior to the discovery of specimens …

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Distribution And Status Of The Southern Bog Lemming, Synaptomys Cooperi, In Southeastern Virginia, Robert K. Rose Jan 2006

Distribution And Status Of The Southern Bog Lemming, Synaptomys Cooperi, In Southeastern Virginia, Robert K. Rose

Virginia Journal of Science

The Dismal Swamp subspecies of the Southern bog lemming, Synaptomys cooperi helaletes, was named based on specimens collected during the 1895-1898 biological surveys conducted in the Dismal Swamp by the US Department of Agriculture. Unknown in the 20th Century until re-discovered in 1980, this small boreal rodent was believed to be restricted to the Great Dismal Swamp of Virginia and North Carolina where the cool damp conditions had permitted it to survive during the Holocene. However, field studies conducted since 1980 have revealed southern bog lemmings to be widespread throughout southeastern Virginia, with populations encompassing an area of more …

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A Real-Time Pcr-Based Assay For Detection Of Wuchereria Bancrofti Dna In Blood And Mosquitoes, Ramakrishna U. Rao, Laura J. Atkinson, Reda M.R. Ramzy, Hanan H. Helmy, Hoda A. Farid, Moses J. Bockarie, Melinda Susapu, Sandra J. Laney, Steven A. Williams, Gary J. Weil Jan 2006

A Real-Time Pcr-Based Assay For Detection Of Wuchereria Bancrofti Dna In Blood And Mosquitoes, Ramakrishna U. Rao, Laura J. Atkinson, Reda M.R. Ramzy, Hanan H. Helmy, Hoda A. Farid, Moses J. Bockarie, Melinda Susapu, Sandra J. Laney, Steven A. Williams, Gary J. Weil

Biological Sciences: Faculty Publications

We developed and evaluated real-time polymerase chain reaction (PCR) assays for detecting Wuchereria bancrofti DNA in human blood and in mosquitoes. An assay based on detection of the W. bancrofti “LDR” repeat DNA sequence was more sensitive than an assay for Wolbachia 16S rDNA. The LDR-based assay was sensitive for detecting microfilarial DNA on dried membrane filters or on filter paper. We also compared real-time PCR with conventional PCR (C-PCR) for detecting W. bancrofti DNA in mosquito samples collected in endemic areas in Egypt and Papua New Guinea. Although the two methods had comparable sensitivity for detecting filarial DNA in …

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Mutation And Cloning Efficiency, Ronny C. Woodruff, Priti Azad Jan 2006

Mutation And Cloning Efficiency, Ronny C. Woodruff, Priti Azad

Biological Sciences Faculty Publications

No abstract provided.

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Nomenclatural Innovations In Neotropical Salicaeeae, Mac H. Alford Jan 2006

Nomenclatural Innovations In Neotropical Salicaeeae, Mac H. Alford

Faculty Publications

Macrothumia M. H. Alford is described as a new genus of Salicaceae based on Neosprucea kuhlmannii Steamer from Brazil. The deciduous perianth, papillate leaf teeth, presence of receptacular disk glands, and analyses of plastid DNA data Suggest that the new genus is more closely related to Ahernia Merrill and Pleuranthodendron. L. O. Williams than to Banara Aublet or Neosprucea Sleuruer. The monotypic genus Aphaerema Miers of Brazil and Argentina is transferred to Abatia Ruiz & Pavon, based on analyses of plastid DNA sequences and on the lack of morphological discontinuities between the genera. Because the name Abatia spicata (Turczaninow) …

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Cell Cycle Cyclin Expression Of Atrazine Treated Hepg2 Cells Using Western Blot Analysis, April Dawn Rand Jan 2006

Cell Cycle Cyclin Expression Of Atrazine Treated Hepg2 Cells Using Western Blot Analysis, April Dawn Rand

Honors Program Theses

Atrazine is one of the most widely used herbicides in the United States. It is frequently used for general weed control on both industrial and agricultural land. However, atrazine has been associated with many harmful non-target effects in animals and humans. Due to its prevalence in the environment, the United States Environmental Protection Agency (USEP A) has set the maximal contaminant level of atrazine in drinking water at 3 ppb (USEP A, 2003 ). One of the non-target effects of atrazine is slowed growth of both normal and immortalized human cells. Previous work from our lab demonstrated that exposing normal …

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Use Of Gamma Rays To Induce Mutations In Four Pea (Pisum Sativum L.) Cultivars, Cemaletti̇n Y. Çi̇ftçi̇, Asli Di̇vanli Türkan, Khalid Mahmood Khawar, Mehmet Atak, Sebahatti̇n Özcan Jan 2006

Use Of Gamma Rays To Induce Mutations In Four Pea (Pisum Sativum L.) Cultivars, Cemaletti̇n Y. Çi̇ftçi̇, Asli Di̇vanli Türkan, Khalid Mahmood Khawar, Mehmet Atak, Sebahatti̇n Özcan

Turkish Journal of Biology

The study reports a 3-step optimization to find out the effects of cytokinins BAP and TDZ on seed germination and g rays to induce mutations in 4 pea cultivars: Winner, Sprinter, Bolero and Karina. It was observed that germination was independent of the dose of g rays and was mainly affected by the germination capability of the genotypes and doses of BAP and TDZ in the germination medium. Seed germination was better on germination medium containing 50 µM BAP than 10 µM TDZ. Variable rooting was observed on shoots obtained from non-irradiated seeds germinated on MS medium containing 50 µM …

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Increased Expression Of Nadp Malic Enzyme In The Guard Cells Of Arabidopsis Plants, Pooja Thakur Jan 2006

Increased Expression Of Nadp Malic Enzyme In The Guard Cells Of Arabidopsis Plants, Pooja Thakur

Master's Theses and Doctoral Dissertations

Plants lose their water as transpiration by stomatal opening, which is governed by guard cells surrounding the stomata. Influx of ions such as K+, Cl-, from neighboring cells into guard cells, and malate synthesis within guard cells increases turgor pressure opening the stomata. Stomata close when K+ and Cl- efflux out, and the cytosolic isoform of NADP ME convert malate to pyruvate. We hypothesize that stomatal closure can be controlled by increased NADP ME activity in guard cells. More than one of the homozygous transgenic Arabidopsis plants that are transformed with a guard cell promoter driving expression …

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"Remarks On The Freshwater Crabs Of Angola, Southwestern Africa, With The Description Of Potamonautes Kensleyi, New Species" , Neil Cumberlidge, Marcos Tavares Jan 2006

"Remarks On The Freshwater Crabs Of Angola, Southwestern Africa, With The Description Of Potamonautes Kensleyi, New Species" , Neil Cumberlidge, Marcos Tavares

Journal Articles

No abstract provided.

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"Forza Raimundi, A New Genus And Species Of Potamonautid Freshwater Crab From Northern Madagascar" , Sadie K. Reed, Neil Cumberlidge Jan 2006

"Forza Raimundi, A New Genus And Species Of Potamonautid Freshwater Crab From Northern Madagascar" , Sadie K. Reed, Neil Cumberlidge

Journal Articles

No abstract provided.

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Degenerate Oligonucleotide Primed - Polymerase Chain Reaction Evaluation And Optimization To Improve Downstream Forensic Str Analysis Of Low Quality/Low Quantity Dna, Lindsay Paige Thompson Jan 2006

Degenerate Oligonucleotide Primed - Polymerase Chain Reaction Evaluation And Optimization To Improve Downstream Forensic Str Analysis Of Low Quality/Low Quantity Dna, Lindsay Paige Thompson

Theses and Dissertations

When forensic biological samples yield low quality/low quantity DNA, thecurrent STR analysis methods do not generate acceptable profiles. Whole genomeamplification can be used to pre-amplify the entire genome for downstream analyses. A commercially available kit for DOP-PCR, a form of WGA, is currently being used in the clinical for downstream single locus targets. Forensic analyses utilize a multiplex amplification. This study determined that the "home brew" created by our lab performs the same as the commercially available kit. Future optimization studies of DOP-PCR can utilize this "home brew". Additionally, this research determined that a 10 second increase in electrokinetic injection …

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Acquisition And Retention Of Bacterial Spores (Bacillus Atrophaeus) By Eight Insect Species, Kieron Marie Torres Jan 2006

Acquisition And Retention Of Bacterial Spores (Bacillus Atrophaeus) By Eight Insect Species, Kieron Marie Torres

Theses and Dissertations

Acquisition and retention of spores of an anthrax surrogate, Bacillus atrophaeus Nakamura ("BG") were evaluated in eight insect species. Species included: house cricket (Acheta domesticus L.), German cockroach (Blatella germanica L.), common house fly (Musca domestics L.), blue bottle fly (Calliphora vomitoria L.), hairy rove beetle Creophilus maxillosus L.), yellow mealworm (Tenebrio molitor L.), common paper wasps (Polistes exclamans exclamans Viereck), red paper wasps (Polistes Carolina L.), red harvester ant (Pogonymyrmex barbatus Smith). Individual insects were offered BG-treated food and sacrificed at specified time intervals following one, two or three meals. Resulting samples were surface-washed five consecutive times then homogenized …

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Genetic Assessment Of Rare Blackbanded Sunfish (Enneacanthus Chaetodon) Populations In Virginia, Diana Marie Kercher Jan 2006

Genetic Assessment Of Rare Blackbanded Sunfish (Enneacanthus Chaetodon) Populations In Virginia, Diana Marie Kercher

Theses and Dissertations

Enneacanthus chaetodon, the blackbanded sunfish, has become increasingly rare throughout its distribution in the Eastern United States. In Virginia, E. chaetodon maintains an endangered status and individuals persist in six populations. Mitochondrial DNA (mtDNA) and microsatellite data were assessed to determine the genetic characters and gene diversity of the Virginia populations. The results of these analyses were then compared to five additional populations; four from New Jersey and one from North Carolina that were known to have relatively good fitness and were not impacted severely by habitat alteration. The results of this study are relevant to selection of proper management …

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Invasion Genetics Of The Blue Catfish (Ictalurus Furcatus) Range Expansion Into Large River Ecosystems Of The Chesapeake Bay Watershed, Colleen Beth Higgins Jan 2006

Invasion Genetics Of The Blue Catfish (Ictalurus Furcatus) Range Expansion Into Large River Ecosystems Of The Chesapeake Bay Watershed, Colleen Beth Higgins

Theses and Dissertations

The blue catfish, Ictalurus furcatus (Ictaluridae), is ranked among the most invasive, nonnative species of concern in the Chesapeake Bay watershed. This species, intentionally introduced to three major tributaries and a number of impoundments between 1974 and 1989 for sport fishing, has spread into three additional tributaries. Using samples from the introduced tributary populations as a baseline, we evaluated microsatellite genetic variation in light of demographic and ecological data to elucidate the potential sources of the invasive I. furcatus populations. In general, the populations surveyed in the Chesapeake Bay watershed were considerably more inbred (F ranged from 0.03 - 0.27) …

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Degenerate Oligonucleotide Primed-Pcr: Thermalcycling Modifications And Comparison Studies, Denise N. Rodier Jan 2006

Degenerate Oligonucleotide Primed-Pcr: Thermalcycling Modifications And Comparison Studies, Denise N. Rodier

Theses and Dissertations

Degenerate Oligonucleotide Primed-PCR (DOP-PCR) can potentially enhance analysis of low copy number DNA samples. Theoretically, this procedure replicates fragments of the genome that can then be used for downstream multiplex STR analysis. The objective of this study is to optimize DOP-PCR by examining ramplelongation times and cycle numbers in the non-specific amplification portion of DOP-PCR, and by modifying the degenerate primer. Additionally, other methods such as Multiple Displacement Amplification (MDA) and Low Copy Number PCR (LCN PCR) were examined for their ability to create accurate DNA profiles from low DNA input amounts. Increasing the ramplelongation times showed no effect on …

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The Effect Of Tgf-B And Egf On Mmp-2 Activation And Mt1-Mmp Phosphorylation In U87mg And T98g Human Glioma Cells, Jacquelyn B. Knupp Jan 2006

The Effect Of Tgf-B And Egf On Mmp-2 Activation And Mt1-Mmp Phosphorylation In U87mg And T98g Human Glioma Cells, Jacquelyn B. Knupp

Honors Theses

Glioblastoma multiforme (GBM), a high-grade, malignant brain tumor of astrocyte origin, invades normal brain tissue and most often results in death ofthe patient withinayearofdiagnosis. In order to invade the surrounding tissue and thereby metastasize, these tumor cells must migrate through the extracellular matrix. The pmpose ofthis research project is to investigate the family ofmatrix metalloproteinases responsible for extracellular degradation. Specifically, this investigation looks at MMP-2 activation via MT 1-MMP and the possible importance of phosphorylation of the tyrosine residue on the cytoplasmic tail of MTl-MMP. U87wildtypegliomacellsaswellasT98 p53 mutant glioma cells were treated with transforming growth factor beta (TGF-P). Preliminary results …

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Eye Development At The Houston "Fly Meeting", Amit Singh Jan 2006

Eye Development At The Houston "Fly Meeting", Amit Singh

Biology Faculty Publications

Meeting report: The 47th Annual Drosophila Research Conference or "Fly Meeting" took place at Houston, Texas, USA from March 29th- April 2nd, 2006, under the aegis of the Genetics Society of America. The Fly Meeting provides an excellent opportunity for fly researchers to present their work and to get a snapshot of recent developments and upcoming trends in their research field. The fruit fly, Drosophila melanogaster, is a very versatile model to study growth, patterning, neural development, evolution, systemetics and various other facets of biomedical science. The topics presented in the meeting covered a very broad spectrum of fly research. …

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Gene Expression And Discovery During Lens Regeneration In Mouse: Regulation Of Epithelial To Mesenchymal Transition And Lens Differentiation, Mario Medvedovic, Craig R. Tomlinson, Mindy Kay Call, Matthew Grogg, Panagiotis A. Tsonis Jan 2006

Gene Expression And Discovery During Lens Regeneration In Mouse: Regulation Of Epithelial To Mesenchymal Transition And Lens Differentiation, Mario Medvedovic, Craig R. Tomlinson, Mindy Kay Call, Matthew Grogg, Panagiotis A. Tsonis

Biology Faculty Publications

Purpose: It has been shown that after extracapsular lens removal by anterior capsulotomy in the mouse, the lens can be regenerated. However, as the capsular bag is filled with fibers, epithelial to mesenchymal transition (EMT), an event which is common after cataract surgery as well, takes place during early stages. This study, using a unique mouse model, was undertaken to identify novel regulators and networks in order to more clearly understand secondary cataracts at the molecular level.

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Comparison Of Dot Chromosome Sequences From D. Melanogaster And D. Virilis Reveals An Enrichment Of Dna Transposon Sequences In Heterochromatic Domains, Elizabeth Slawson, Christopher Shaffer, Colin Malone, Wilson Leung, Elmer Kellmann, Rachel Shevchek, Carolyn Craig, Seth Bloom, James Bogenpohl 2nd, James Dee, Emiko Morimoto, Jenny Myoung, Andrew Nett, Fatih Ozsolak, Mindy Tittiger, Andrea Zeug, Mary-Lou Pardue, Jeremy Buhler, Elaine Mardis, Sarah C.R. Elgin Jan 2006

Comparison Of Dot Chromosome Sequences From D. Melanogaster And D. Virilis Reveals An Enrichment Of Dna Transposon Sequences In Heterochromatic Domains, Elizabeth Slawson, Christopher Shaffer, Colin Malone, Wilson Leung, Elmer Kellmann, Rachel Shevchek, Carolyn Craig, Seth Bloom, James Bogenpohl 2nd, James Dee, Emiko Morimoto, Jenny Myoung, Andrew Nett, Fatih Ozsolak, Mindy Tittiger, Andrea Zeug, Mary-Lou Pardue, Jeremy Buhler, Elaine Mardis, Sarah C.R. Elgin

Biology Faculty Research

Background: Chromosome four of Drosophila melanogaster, known as the dot chromosome, is largely heterochromatic, as shown by immunofluorescent staining with antibodies to heterochromatin protein 1 (HP1) and histone H3K9me. In contrast, the absence of HP1 and H3K9me from the dot chromosome in D. virilis suggests that this region is euchromatic. D. virilis diverged from D. melanogaster 40 to 60 million years ago. Results: Here we describe finished sequencing and analysis of 11 fosmids hybridizing to the dot chromosome of D. virilis (372,650 base-pairs) and seven fosmids from major euchromatic chromosome arms (273,110 base-pairs). Most genes from the dot chromosome of …

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