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Articles 451 - 480 of 505
Full-Text Articles in Biology
Diet: Charina Bottae, T. J. Devitt, Ryan I. Hill, S. E. Cameron
Diet: Charina Bottae, T. J. Devitt, Ryan I. Hill, S. E. Cameron
College of the Pacific Faculty Articles
No abstract provided.
Gene Set Coregulated By The Saccharomyces Cerevisiae Nonsense-Mediated Mrna Decay Pathway, Rachel Taylor, Bessie Wanja Kebaara, Tara Nazarenus, Ashley Jones, Rena Yamanaka, Rachel Uhrenholdt, Jason P. Wendler, Audrey L. Atkin
Gene Set Coregulated By The Saccharomyces Cerevisiae Nonsense-Mediated Mrna Decay Pathway, Rachel Taylor, Bessie Wanja Kebaara, Tara Nazarenus, Ashley Jones, Rena Yamanaka, Rachel Uhrenholdt, Jason P. Wendler, Audrey L. Atkin
School of Biological Sciences: Faculty Publications
The nonsense-mediated mRNA decay (NMD) pathway has historically been thought of as an RNA surveillance system that degrades mRNAs with premature translation termination codons, but the NMD pathway of Saccharomyces cerevisiae has a second role regulating the decay of some wild-type mRNAs. In S. cerevisiae, a significant number of wild-type mRNAs are affected when NMD is inactivated. These mRNAs are either wild-type NMD substrates or mRNAs whose abundance increases as an indirect consequence of NMD. A current challenge is to sort the mRNAs that accumulate when NMD is inactivated into direct and indirect targets. We have developed a …
Comparison Of Phytoplankton And Autotrophic Picoplankton Populations Over A 24-Hour Period From A Pond's Surface And Subsurface Waters, Harold G. Marshall, Lubomira Burchardt, Elżbieta Wilk-Woźniak
Comparison Of Phytoplankton And Autotrophic Picoplankton Populations Over A 24-Hour Period From A Pond's Surface And Subsurface Waters, Harold G. Marshall, Lubomira Burchardt, Elżbieta Wilk-Woźniak
Biological Sciences Faculty Publications
Phytoplankton abundance and composition relationships within the surface layer changed over short time periods (4-6 hours) in comparison with more constant associations at 2 cm below the surface. Both strata had a diverse algal flora (>50 taxa), but no distinct neuston assemblage characterized the surface layer algal composition over the 24-hour study. The similarity between the two strata indicated the floral composition of the surface layer came from the water column algae below the surface. Chlorophytes, diatoms, cyanobacteria, and cryptophytes represented the most abundant algal categories for both strata with a total mean phytoplankton abundance of 3,566 cells ml …
Mechanical Properties Of The Integument Of The Common Gartersnake, Thamnophis Sirtalis (Serpentes: Colubridae), Gabriel Rivera, Alan H. Savitzky, Jeffrey A. Hinkley
Mechanical Properties Of The Integument Of The Common Gartersnake, Thamnophis Sirtalis (Serpentes: Colubridae), Gabriel Rivera, Alan H. Savitzky, Jeffrey A. Hinkley
Biological Sciences Faculty Publications
The evolution of the ophidian feeding mechanism has involved substantial morphological restructuring associated with the ability to ingest relatively large prey. Previous studies examining the morphological consequences of macrophagy have concentrated on modifications of the skull and cephalic musculature. Although it is evident that macrophagy requires highly compliant skin, the mechanical properties of the ophidian integument have received limited attention, particularly in the context of feeding. We examined mechanical properties of skin along the body axis in Thamnophis sirtalis (Colubridae). Data were collected from tensile tests and were analyzed using a multivariate analysis of variance (MANOVA) and post-hoc multiple comparison …
The Architecture Of A Proteomic Network In The Yeast, Emad Ramadan, Christopher Osgood, Alex Pothern
The Architecture Of A Proteomic Network In The Yeast, Emad Ramadan, Christopher Osgood, Alex Pothern
Biological Sciences Faculty Publications
We describe an approach to clustering the yeast protein-protein inter-action network in order to identify functional modules, groups of proteins forming multi-protein complexes accomplishing various functions in the cell. We have developed a clustering method that accounts for the small-world nature of the network. The algorithm makes use of the concept of k-cores in a graph, and employs recursive spectral clustering to compute the functional modules. The computed clusters are annotated using their protein memberships into known multi-protein complexes in the yeast. We also dissect the protein interaction network into a global subnetwork of hub proteins (connected to several clusters), …
3,4-Methylenedioxymethamphetamine Activates Nuclear Factor- Κb, Increases Intracellular Calcium, And Modulates Gene Transcription In Rat Heart Cells, David A. Tiangco, Frank A. Lattanzio Jr., Christopher J. Osgood, Stephen J. Beebe, Julie A. Kerry, Barbara Y. Hargrave
3,4-Methylenedioxymethamphetamine Activates Nuclear Factor- Κb, Increases Intracellular Calcium, And Modulates Gene Transcription In Rat Heart Cells, David A. Tiangco, Frank A. Lattanzio Jr., Christopher J. Osgood, Stephen J. Beebe, Julie A. Kerry, Barbara Y. Hargrave
Biological Sciences Faculty Publications
3,4-Methylenedioxymethamphetamine (MDMA) is an illicit psychoactive drug that has gained immense popularity among teenagers and young adults. The cardiovascular toxicological consequences of abusing this compound have not been fully characterized. The present study utilized a transient transfection/dual luciferase genetic reporter assay, fluorescence confocal microscopy, and gene expression macroarray technology to determine nuclear factor-κB (NF-κB) activity, intracellular calcium balance, mitochondrial depolarization, and gene transcription profiles, respectively, in cultured rat striated cardiac myocytes (H9c2) exposed to MDMA. At concentrations of 1×10−3 M and 1×10−2 M, MDMA significantly enhanced NF-κB reporter activity compared with 0 M (medium only) control. This …
A Defensin-Like Gene Expressed In The Black-Legged Tick, Ixodes Scapularis (Acari: Ixodidae), Wayne L. Hynes, S. M. Ceraul, S. M. Todd, K. C. Seguin, Daniel E. Sonenshine
A Defensin-Like Gene Expressed In The Black-Legged Tick, Ixodes Scapularis (Acari: Ixodidae), Wayne L. Hynes, S. M. Ceraul, S. M. Todd, K. C. Seguin, Daniel E. Sonenshine
Biological Sciences Faculty Publications
The black-legged tick Ixodes scapularis linnaeus (Acari: Ixodidae) is an important vector of microbial pathogens. Knowledge of the tick's innate immune response, particularly defensin and other antimicrobial peptides, is important for understanding how microbes survive in this tick. A defensin gene (slnA) from I. scapularis was obtained by reverse transcription-polymerase chain reaction (RT-PCR) using mRNA extracted from tissues of female ticks. RT-PCR indicated the gene was expressed in the midgut, haemocytes, and fat-body, although no evidence of a peptide was found. Sequencing a cloned cDNA fragment revealed a 225 bp open reading frame encoding a 74 amino acid pre-prodefensin, including …
Habitat Selection In Four Sympatric Small Mammal Species And The Effects Of Potential Predators On Peromyscus Leucopus, Adam Daniel Chupp
Habitat Selection In Four Sympatric Small Mammal Species And The Effects Of Potential Predators On Peromyscus Leucopus, Adam Daniel Chupp
Theses and Dissertations
I examined the effects of potential predators in relation to habitat selection in Peromyscus leucopus. I also examined habitat selection in three other sympatric species (Blarina brevicauda, Blarina carolinensis, Sorex longirostris). I utilized data fiom 49 sampling sites on National Park Service land; Petersburg National Battlefield Eastern Front Unit (15), Five-Forks Unit (17), Appomattox Court House National Historical Park (15) and Booker T. Washington National Monument (12). Sites were categorized by location (park unit) and habitat type (i.e. bottom-land hardwood), and the microhabitat within each sampling site was characterized by four variables (% cover of grasses, herbs, shrubs, and volume …
Correlation Between Bioassessments Of Macroinvertebrates And Fishes And Natural Land Cover In Virginia Coastal Plain Watersheds, Warren Hunter Smigo
Correlation Between Bioassessments Of Macroinvertebrates And Fishes And Natural Land Cover In Virginia Coastal Plain Watersheds, Warren Hunter Smigo
Theses and Dissertations
Twenty five first through third order streams in the Coastal Plain of Virginia were sampled for benthic macroinvertebrates and fishes to determine whether a predictable relationship between areas of Unfragmented Natural Land Cover (UNLC) and biotic integrity could be established. I hypothesized that as the area of UNLC increased in a watershed at either the whole catchment or riparian scale, biotic indices measuring stream water and habitat quality would increase. Biotic integrity was measured through the scores from the Coastal Plain Macroinvertebrate Index (CPMI) for benthic macroinvertebrates and the VCU Index of Biotic Integrity (IBI) for fishes. Using GIS, the …
Molecular Identification Of Anopheles Spp. (Diptera: Culicidae) In The Chapare/Carrasco Valleys, Cochabamba, Bolivia, Corey Brelsfoard
Molecular Identification Of Anopheles Spp. (Diptera: Culicidae) In The Chapare/Carrasco Valleys, Cochabamba, Bolivia, Corey Brelsfoard
Masters Theses
Studies on malaria in our "backyard," the Neotropics, have been hampered by the lack of an accurate means of species identification for mosquito vectors of the human malaria parasite (i.e. Plasmodium spp). Mosquitoes in the genus Anopheles are the principle malaria vectors in the Neotropics and are often composed of closely related morphologically similar species complexes. This thesis describes three polymerase chain reaction (PCR) protocols to aid in identifying four anopheline mosquitoes for any life stage, of which three have been incriminated as vectors of human malaria in several locations throughout S. America and might be potential vectors of human …
An Evaluation Of Beaver Habitat Models For Illinois Rivers, Daniel R. Cox
An Evaluation Of Beaver Habitat Models For Illinois Rivers, Daniel R. Cox
Masters Theses
Beavers (Castor canadensis) are agents of landscape change, altering the structure and species composition of vegetative communities through herbivory and water impoundment. To better manage beavers in Illinois, improved methods of monitoring riverine populations of this species are needed. The objectives of the study were to (1) locate, map and quantify the spatial distribution of beaver colonies along the Embarras River, (2) test the efficacy of 2 existing beaver habitat models, the U.S. Fish and Wildlife Service's Habitat Suitability Index (HSI) model and Missouri's beaver habitat model, for predicting the relative density of beavers and (3) develop a new multiple …
The Effects Of Habitat Quality On Abiotic Factors And Heterotrophic Microbial Activity In A Freshwater Stream System, Daphne Kampinga
The Effects Of Habitat Quality On Abiotic Factors And Heterotrophic Microbial Activity In A Freshwater Stream System, Daphne Kampinga
Masters Theses
Much of the Midwest, as well as Illinois' landscape, has largely been transformed from its original habitat of prairie, savanna, wetlands, and forest into corn and soybean fields and urban areas. As a result, less than 1% of the original habitat in Illinois remains intact today. These modifications can lead to habitat fragmentation and affect riparian zone vegetation, which is an important link between the land-water interface and influences processes such as organic matter inputs and water temperature regimes. As a result of fragmentation, riparian zone loss has occurred and catchment vegetation associated with streams can vary from agricultural fields, …
Landscape Effects On Stream Water Chemistry And Benthic Productivity In An Agricultural Watershed, Shari E. Fanta
Landscape Effects On Stream Water Chemistry And Benthic Productivity In An Agricultural Watershed, Shari E. Fanta
Masters Theses
A conceptual model was developed and utilized to investigate the influence of land use/land cover on community metabolism as mediated by stream water chemistry, in an agricultural watershed in east-central Illinois. A suite of physical and chemical variables were sampled over a yearlong period at twelve sites across the Hurricane Creek Watershed. Community metabolism was determined at five of the sites during episodes of suitable hydrologic and weather conditions. A single PCA axis was unique in incorporating significant relationships between land use/land cover, stream water chemistry, as well as community metabolism, thereby validating the conceptual model. The proportion of cropland, …
Copulatory Behaviors Of Male Caribbean Fruit Flies (Anastrepha Suspensa) And Female Sperm Storage Patterns, Holly J. Wallace
Copulatory Behaviors Of Male Caribbean Fruit Flies (Anastrepha Suspensa) And Female Sperm Storage Patterns, Holly J. Wallace
Masters Theses
Countless numbers of insects have copulatory behaviors performed while in copulation. Copulatory behaviors or copulatory courtship performed by males may be a means to influence female sperm storage patterns. Sexual selection in regards to female processes that influence male reproductive success are termed "cryptic female choice." In my thesis I examined copulatory behaviors performed by mass-reared male Anastrepha suspensa and sperm storage patterns in relation to male behavioral performance in females. I videotaped copulating virgin males and females of different ages and recorded mating duration, size of both sexes, male proboscis extensions, male probing of the females' head, thorax and …
Plant Species Turnover As A Mechanism Of Community Change In Response To Biotic And Abiotic Perturbation, Kathryn Anne Yurkonis
Plant Species Turnover As A Mechanism Of Community Change In Response To Biotic And Abiotic Perturbation, Kathryn Anne Yurkonis
Masters Theses
Plant communities change through time as species respond to changes in their biotic and abiotic environment. Biotic factors influencing plant communities can include species invasion, competition, or herbivory, whereas abiotic factors can include drought, fire, or nutrient deposition. Although factors influencing community structure have been extensively documented, the mechanisms by which communities respond to disturbances are not well understood. To address this problem, my thesis research considered two perturbations, exotic species invasion and drought, in each case I specifically relate species turnover to changes in community structure. The overall goal of this project was to evaluate the utility of using …
Common Names For The Frog Genus Leptodactylus (Amphibia, Anura, Leptodactylidae), Ulisses Caramaschi, Rafael O. De Sá, W. Ronald Heyer
Common Names For The Frog Genus Leptodactylus (Amphibia, Anura, Leptodactylidae), Ulisses Caramaschi, Rafael O. De Sá, W. Ronald Heyer
Biology Faculty Publications
Most species of the frog genus Leptodactylus lack common names. Common names are those names used by different human cultures and societies for the species of animals and plants where humans and biota reside together. Often times common names are lacking for Neotropical frogs or are broad in scope. For example, indigenous people may have a single name for frogs that occur on the ground and another name for frogs that occur in shrubs and trees, even though there are many species of ground frogs called by the same name as well as for the tree frogs. Sometimes colonists have …
2005 Virginia Wildflower Of The Year: Bloodroot, Sanguinaria Canadensis, W. John Hayden
2005 Virginia Wildflower Of The Year: Bloodroot, Sanguinaria Canadensis, W. John Hayden
Biology Faculty Publications
Bloodroot is an herbaceous perennial that grows from a persistent, branched underground stem or rhizome. Early each spring, while the forest canopy is still bare, each well-developed rhizome tip produces one leaf and one flower stalk. The leaf is kidney-shaped in its overall outline, but it is also divided into a pattern of rounded lobes and sinuses, rendering a complex overall shape. At flowering time, bloodroot leaves form a loose vertically-oriented collar around the flower stalk with the bluish-green lower leaf surface forming the outside of the collar; as the season progresses, the leaves open flat and expand to their …
Invertebrate Diversity In Taylor Valley Soils And Sediments, Amy M. Treonis, Diana H. Wall, Ross A. Virginia
Invertebrate Diversity In Taylor Valley Soils And Sediments, Amy M. Treonis, Diana H. Wall, Ross A. Virginia
Biology Faculty Publications
Explaining how ecosystems function across variable landscapes will require knowledge of biodiversity patterns. In particular, biodiversity studies of soils and sediments will help in understanding the linkages between ecosystem processes in both of these habitats (Freckman et al. 1997). Soils and sediments are domains for ecosystem processes such as decomposition and trace gas exchange. There are few studies, however, that have compared abundance and diversity of organisms in adjacent soils and sediments (Freckman et al. 1997). The goal of this study was to increase understanding of how the biotic communities involved in ecosystem processes are organized within an important feature …
Common Names For The Frog Genus Leptodactylus (Amphibia, Anura, Leptodactylidae), Ulisses Caramaschi, Rafael O. De Sá, W. Ronald Heyer
Common Names For The Frog Genus Leptodactylus (Amphibia, Anura, Leptodactylidae), Ulisses Caramaschi, Rafael O. De Sá, W. Ronald Heyer
Biology Faculty Publications
Most species of the frog genus Leptodactylus lack common names. Common names are those names used by different human cultures and societies for the species of animals and plants where humans and biota reside together. Often times common names are lacking for Neotropical frogs or are broad in scope. For example, indigenous people may have a single name for frogs that occur on the ground and another name for frogs that occur in shrubs and trees, even though there are many species of ground frogs called by the same name as well as for the tree frogs. Sometimes colonists have …
Are Leptodactylus Didymus And L. Mystaceus Phylogenetically Sibling Species (Amphibia, Anura, Leptodactylidae)?, Rafael O. De Sá, W. R. Heyer, A. Camargo
Are Leptodactylus Didymus And L. Mystaceus Phylogenetically Sibling Species (Amphibia, Anura, Leptodactylidae)?, Rafael O. De Sá, W. R. Heyer, A. Camargo
Biology Faculty Publications
The Leptodactylus fuscus species group consists of 25 currently recognized species; within this species group and distributed throughout the Amazon Basin, Atlantic Forests, Gran Chaco, and cerrados is the L. mystaceus species complex. This species complex consists of L. didymus, L. elenae, L. mystaceus, L. notoaktites, and L. spixi. Adult morphologies have been used to distinguish these species from each other except for L. didymus and L. mystaceus (Heyer, 1978; Heyer et al., 1996). Leptodactylus didymus and L. mystaceus are morphologically indistinguishable; the species are recognizable only by the characteristics of their advertisement calls: non-pulsed in L. didymus and pulsed …
On The Enigmatic Distribution Of The Honduran Endemic Leptodactylus Silvanimbus (Amphibia: Anura: Lep Todactylidae), W. Ronald Heyer, Rafael O. De Sá, Sarah Muller
On The Enigmatic Distribution Of The Honduran Endemic Leptodactylus Silvanimbus (Amphibia: Anura: Lep Todactylidae), W. Ronald Heyer, Rafael O. De Sá, Sarah Muller
Biology Faculty Publications
Most species of the frog genus Leptodactylus occur in South America, and all authors who have treated the zoogeography of the genus have concluded that it originated somewhere in South America (e.g., Savage 1982). Savage (1982,518) summarized the historical herpetofaunal units of the Neotropics as follows: "All evidence points to an ancient contiguity and essential similarity of a generalized tropical herpetofauna that ranged over tropical North, Middle, and most of South America in Cretaceous-Paleocene times. Descendents of this fauna are represented today by the South and Middle American tracks (Elements). To the north of this fauna ranged a subtropical-temperate Laurasian …
Diet Composition Of Juvenile Fish Reflects Adaptation To Altered Prey Communities In A Reservoir Receiving Thermal Effluent, Brian A. Metzke
Diet Composition Of Juvenile Fish Reflects Adaptation To Altered Prey Communities In A Reservoir Receiving Thermal Effluent, Brian A. Metzke
Masters Theses
Survival, and ultimately recruitment. of planktivorous juvenile fish is related to prey availability. Temperature regime and introduction of exotic species can change zooplankton community dynamics and alter trophic relationships between juvenile fish and their prey. Newton Lake, located in Jasper County, Illinois is used as a cooling reservoir for a coal burning power plant. Thermal effluent produced by the power plant is released into only one of two reservoir arms creating a temperature gradient. Newton Lake also contains Daphnia lumholtzi, an exotic zooplankter thought to create feeding difficulties for gape-limited predators like juvenile fish. It is within the context of …
The Drosophila Lymph Gland As A Developmental Model Of Hematopoiesis, Seung Hye Jung, Cory J. Evans, Christine Uemura, Utpal Banerjee
The Drosophila Lymph Gland As A Developmental Model Of Hematopoiesis, Seung Hye Jung, Cory J. Evans, Christine Uemura, Utpal Banerjee
Biology Faculty Works
Drosophila hematopoiesis occurs in a specialized organ called the lymph gland. In this systematic analysis of lymph gland structure and gene expression, we define the developmental steps in the maturation of blood cells (hemocytes) from their precursors. In particular, distinct zones of hemocyte maturation, signaling and proliferation in the lymph gland during hematopoietic progression are described. Different stages of hemocyte development have been classified according to marker expression and placed within developmental niches: a medullary zone for quiescent prohemocytes, a cortical zone for maturing hemocytes and a zone called the posterior signaling center for specialized signaling hemocytes. This establishes a …
Transgenic Mouse Model Of Tau Pathology In Astrocytes Leading To Nervous System Degeneration, Deepa V. Dabir
Transgenic Mouse Model Of Tau Pathology In Astrocytes Leading To Nervous System Degeneration, Deepa V. Dabir
Biology Faculty Works
Filamentous tau inclusions in neurons and glia are neuropathological hallmarks of sporadic and familial tauopathies. Because tau gene mutations are pathogenic for the autosomal dominant tauopathy "frontotemporal dementia and parkinsonism linked to chromosome 17," tau abnormalities are implicated directly in the onset and/or progression of disease. Although filamentous tau aggregates are acknowledged to play roles in degenerative mechanisms resulting in neuron loss, the contributions of glial tau pathology to neurodegeneration remain essentially unexplored. To begin to elucidate the role of glial pathology in tauopathies, we generated a transgenic (Tg) mouse model of astrocytic tau pathology by expressing the human tau …
"Tree-Climbing Crabs From Phytotemic Microhabitats In Rainforest Canopy In Madagascar" , Neil Cumberlidge, Dante B. Fenolio, Mark E. Walvoord, Jim Stout
"Tree-Climbing Crabs From Phytotemic Microhabitats In Rainforest Canopy In Madagascar" , Neil Cumberlidge, Dante B. Fenolio, Mark E. Walvoord, Jim Stout
Journal Articles
No abstract provided.
Cryopreservation Of Human Hematopoietic Stem And Progenitor Cells Loaded With Trehalose : Transient Permeabilization Via The Adenosine Triphosphate-Dependent P2z Receptor Channel., Sandhya S. Buchanan, Michael A. Menze, Steven C. Hand, David W. Pyatt, John F. Carpenter
Cryopreservation Of Human Hematopoietic Stem And Progenitor Cells Loaded With Trehalose : Transient Permeabilization Via The Adenosine Triphosphate-Dependent P2z Receptor Channel., Sandhya S. Buchanan, Michael A. Menze, Steven C. Hand, David W. Pyatt, John F. Carpenter
Faculty and Staff Scholarship
Hematopoietic stem and progenitor cells (HPCs) are a heterogenic population of cells used to treat a number of human diseases. Multilineage differentiation is a required function in successful hematopoietic reconstitution after transplantation of cryopreserved grafts. Conventional use of the cryoprotectant dimethyl sulfoxide (DMSO) has resulted in some reports of infusion related toxicity attributed to DMSO and/or damage to cells during freezethawing procedures. The purpose of this study was to explore the use of trehalose, a nontoxic disaccharide of glucose, as an alternative cryoprotectant. Trehalose was introduced into HPCs using the P2Z receptor, known to form nonselective pores in the presence …
Comparison Of Dna Extraction From Cervical Cells Collected In Preservcyt Solution For The Amplification Of Chlamydia Trachomatis, Helen Keegan, Clara Boland, Alison Malkin, Mairead Griffin, Fergus Ryan, Helen Lambkin
Comparison Of Dna Extraction From Cervical Cells Collected In Preservcyt Solution For The Amplification Of Chlamydia Trachomatis, Helen Keegan, Clara Boland, Alison Malkin, Mairead Griffin, Fergus Ryan, Helen Lambkin
Articles
Objective: The aim of this study was to compare and evaluate three methods of DNA extraction for the amplification of Chlamydia trachomatis in uterine cervical samples collected in PreservCyt solution. ThinPrep is the trade name for the slide preparation. Methods: Thirty-eight samples collected in LCx buffer medium, which were identified as C. trachomatis infected by ligase chain reaction (LCR), were selected for this study. DNA from the PreservCyt samples was extracted by three methods: (i) QIAamp kit, (ii) boiling in Tris-EDTA buffer with Chelex purification, and (iii) Proteinase K digestion with Chelex purification. Sample DNA was tested for the presence …
Validation Of A Multiplex Pcr Assay For The Simultaneous Detection Of Human Papillomavirus And Chlamydia Trachomatis In Cervical Preservcyt Samples., Helen Keegan, Alison Malkin, Mairead Griffin, Fergus Ryan, Helen Lambkin
Validation Of A Multiplex Pcr Assay For The Simultaneous Detection Of Human Papillomavirus And Chlamydia Trachomatis In Cervical Preservcyt Samples., Helen Keegan, Alison Malkin, Mairead Griffin, Fergus Ryan, Helen Lambkin
Articles
No abstract provided.
Allosteric Models For Multimeric Proteins : Oxygen-Linked Effector Binding In Hemocyanin., Michael Menze, Nadja Hellman, Heinz Decker, Manfred Grieshaber
Allosteric Models For Multimeric Proteins : Oxygen-Linked Effector Binding In Hemocyanin., Michael Menze, Nadja Hellman, Heinz Decker, Manfred Grieshaber
Faculty and Staff Scholarship
In many crustaceans, changing concentrations of several low molecular weight compounds modulates hemocyanin oxygen binding, resulting in lower or higher oxygen affinities of the pigment. The nonphysiological effector caffeine and the physiological modulator urate, the latter accumulating in the hemolymph of the lobster Homarus Vulgaris during hypoxia, increase hemocyanin oxygen affinity and decrease cooperativity of oxygen binding. To derive a model that describes the mechanism of allosteric interaction between hemocyanin and oxygen in the presence of urate or caffeine, studies of oxygen, urate, and caffeine binding to hemocyanin were performed. Exposure of lobster hemocyanin to various pH values between 7.25 …
The Challenge Of Environmental Protection, Jennifer Mattei
The Challenge Of Environmental Protection, Jennifer Mattei
Biology Faculty Publications
Connecticut is in the midst of a demographic transition to a period of lower population growth. These demographic changes will help check the pressures exerted on the state's natural resources by population growth. Water, air, soil, energy sources, food, fisheries, forests, and biodiversity are common pool resources upon which we depend in ways that transcend political boundaries. Those governing Connecticut should help turn the state into a model of how to manage natural resources by halting forest fragmentation, reducing pollution, and promoting environmental science education.