Biology Commons^™

Keefektifan Gambar Statis, Gambar Dinamis Ball-And-Stick, Dan Model Molekul Sederhana Yang Dibuat Dari Jarum Pentul Pada Pembelajaran Bentuk Dan Kepolaran Molekul, Muhammad Ardiansyah

Jurnal Pendidikan Sains

Tujuan penelitian ini adalah untuk membandingkan keefektifan gambar statis, gambar dinamis ball-and-stick, dan model molekul sederhana dibuat dari jarum pentul ditinjau dari hasil belajar kognitif siswa pada pembelajaran bentuk dan kepolaran molekul. Data penelitian adalah skor hasil belajar kognitif siswa yang dikumpulkan dengan menggunakan tes pilihan ganda yang terdiri dari 35 item dengan validitas isi tes sebesar 87,6%, dan koefisien reliabilitas, dihitung dengan rumus KR-21, sebesar 0,90. Data penelitian dianalisis menggunakan statistik uji t. Hasil penelitian menunjukkan bahwa skor hasil belajar kognitif siswa yang diperoleh dari pembelajaran bentuk dan kepolaran molekul dengan menggunakan model molekul sederhana dibuat dari jarum pentul …

Upland Habitat Quality And Historic Landscape Composition Influence Genetic Variation Of A Pond-Breeding Salamander, Stephen C. Richter, Steve J. Price, Chelsea S. Kross, Jeremiah R. Alexander, Michael E. Dorcas

Forestry and Natural Resources Faculty Publications

Understanding the temporal and spatial scale at which habitat alteration impacts populations is important for conservation and management. Amphibians have declined more than other vertebrates, and pond-breeding species are particularly susceptible to habitat loss and fragmentation because they have terrestrial and aquatic life stages. One approach to management of pond-breeding species is protection of core upland habitat surrounding the breeding pond. We used genetic variation as an indicator of population status in a common amphibian species, spotted salamanders (Ambystoma maculatum), to determine how amount of suitable upland habitat relates to population status in the greater Charlotte, North Carolina, …

Incorporating Satellite Derived Cloud Climatologies To Improve High Resolution Interpolation Of Daily Precipitation., Adam M. Wilson, Benoit Parmentier, Brian Mcgill, Rob Guralnick, Walter Jetz

Yale Day of Data

Conservation of biodiversity demands comprehension of evolutionary and ecological patterns and processes that occur over vast spatial and temporal scales. A central goal of ecology is to understand the factors that control the spatial distribution of species and this has become even more important in the face of climate change. However, at global scales there can be enormous uncertainty in environmental data used to model species distributions. Even ‘simple’ metrics such as mean annual precipitation are difficult to estimate in areas with few weather stations and available data sets do not quantify uncertainty in these surfaces. We are developing a …

Thinking Aloud In The Science Classroom: Can A Literacy Strategy Increase Student Learning In Science?, Lindsey Joan Mockel

Dissertations and Theses

This research study investigated the effect of using the think aloud protocol while reading informational text on students' ability to learn from text in a secondary science classroom. The participants in this study were high school students (n=47) in three classes of a mixed-grade Integrated Biology, Chemistry, and Physics course. The study tracked student achievement during a four-week curriculum unit on the theory of evolution and evidence for biological evolution. All students received instruction on using the think aloud protocol, and all students practiced the think aloud protocol when reading short articles related to scientific evidence for evolution. The researcher …

2013 Annual Meeting Program

Journal of the South Carolina Academy of Science

No abstract provided.

Climate Change And Plant Demography In The Sagebrush Steppe, Aldo Compagnoni

Green Canyon Environmental Research Area, Logan Utah

No abstract provided.

Using Economic Instruments To Develop Effective Management Of Invasive Species: Insights From A Bioeconomic Model, Shana M. Mcdermott, Rebecca E. Irwin, Brad W. Taylor

Dartmouth Scholarship

Economic growth is recognized as an important factor associated with species invasions. Consequently, there is increasing need to develop solutions that combine economics and ecology to inform invasive species management. We developed a model combining economic, ecological, and sociological factors to assess the degree to which economic policies can be used to control invasive plants. Because invasive plants often spread across numerous properties, we explored whether property owners should manage invaders cooperatively as a group by incorporating the negative effects of invader spread in management decisions (collective management) or independently, whereby the negative effects of invasive plant spread are ignored …

Penggunaan Pita Melalui Pembelajaran Missouri Mathematics Project Untuk Memahamkan Siswa Tentang Luas Permukaan Bola, Pentri Arfia Dewi

Jurnal Pendidikan Sains

Penelitian ini akan mendeskripsikan penggunaan pita melalui pembelajaran Missouri Mathematics Project untuk memahamkan siswa tentang luas permukaan bola. Pembelajaran yang dilaksanakan berdasarkan pada tahapan pembelajaran Missouri Mathematics Project yang dipadukan dengan bahan manipulatif. Penelitian ini merupakan penelitian tindakan kelas. Setiap siklus terdiri dari tiga kali pertemuan. Dalam penelitian ini juga dilakukan kajian dari jawaban siswa. Hasil penelitian ini menunjukkan bahwa penerapan pembelajaran menggunakan bahan manipulatif bola dan pita dapat memahamkan siswa tentang luas permukaan bola.

Pembelajaran Berbantuan Multimedia Berdasarkan Teori Beban Kognitif Untuk Meningkatkan Kemampuan Menyelesaikan Masalah Program Linear Siswa X Tkr 1 Smkn 1 Doko, Fifi Damayanti

Jurnal Pendidikan Sains

Berdasarkan teori beban kognitif, pembelajaran efektif terjadi apabila beban intrinsic dikelola dengan baik, beban germane ditingkatkan, dan beban extraneous dikurangi. Penerapan multimedia merupakan salah satu upaya untuk mencapai pembelajaran yang efektif. Penelitian ini mengkaji penerapan pembelajaran matematika berbantuan multimedia dalam meningkatkan kemampuan siswa menyelesaikan masalah program linear. Penelitian ini menggunakan pendekatan penelitian tindakan kelas yang dilaksanakan dalam dua siklus. Hasil penelitian menunjukkan bahwa penggunaan multimedia dapat mengelola beban intrinsic, meningkatkan beban germane, dan mengurangi beban extraneous, sehingga kemampuan siswa dalam menyelesaikan masalah program linear meningkat.

Kajian Morfologi, Anatomi, Dan Agronomi Antara Kedelai Sehat Dengan Kedelai Terserang Cowpea Mild Mottle Virus Serta Pemanfaatannya Sebagai Bahan Ajar Di Sekolah Menengah Kejuruan, As’Ad Syamsul Arifin

Jurnal Pendidikan Sains

Salah satu penyebab rendahnya produktivitas kedelai di Indonesia adalah serangan virus belang samar kacang tunggak, Cowpea mild mottle virus (CPMMV). Penelitian ini merupakan penelitian survei yang bertujuan untuk menggambarkan dan mengumpulkan informasi mengenai kajian morfologi, anatomi, dan agronomi terhadap infeksi CPMMV pada varietas yang terinfeksi dan yang tidak terinfeksi. Data dianalisis secara deskriptif dan inferensial menggunakan ANAVA melalui program SPSS for Windows versi 16. Hasil penelitian menunjukkan bahwa varietas Gumitir sehat, Anjosmoro sehat, Mahameru sehat, MLGG 0021, dan MLGG 0268 memiliki ukuran daun, panjang petiol, serta nisbah daun (L/W dan L/PL) lebih besar dibandingkan varietas yang sakit. Varietas Argopuro sakit …

Pengaruh Model Siklus Belajar Berbantuan Mind Map Terhadap Prestasi Belajar Fisika Ditinjau Dari Kinerja Laboratorium Siswa Kelas Viii Smpn 1 Rejoso Kabupaten Pasuruan, Ary Analisa Rahma

Jurnal Pendidikan Sains

Penelitian ini bertujuan untuk menguji pengaruh model siklus belajar berbantuan mind map terhadap prestasi belajar fisika ditinjau dari kinerja laboratorium siswa kelas VIII pada materi cahaya di SMP Negeri 1 Rejoso, Kabupaten Pasuruan. Penelitian ini merupakan penelitian eksperimen semu dengan rancangan faktorial 2 × 2. Subjek penelitian berjumlah 204 siswa. Instrumen penelitian terdiri atas instrumen perlakuan yang meliputi silabus, RPP, dan LKS, serta instrumen pengukuran berupa instrumen kinerja laboratorium dan tes prestasi belajar fisika. Hasil penelitian menunjukkan bahwa prestasi belajar fisika siswa yang belajar menggunakan model siklus belajar berbantuan mind map lebih tinggi dibandingkan dengan siswa yang belajar melalui pembelajaran …

Pengembangan Profesionalitas Berkelanjutan/Continuing Professional Development (Cpd) Guru Bersertifikat Pendidik Di Smk Rumpun Teknologi Se-Malang Raya, Sujianto Sujianto

Jurnal Pendidikan Sains

Penelitian ini bertujuan untuk mendeskripsikan pengembangan profesionalitas berkelanjutan guru bersertifikat pendidik melalui investasi pengembangan diri, publikasi ilmiah, dan karya inovatif, baik secara mandiri, berkelompok, maupun melembaga. Penelitian menggunakan rancangan deskriptif kuantitatif dengan subjek guru kejuruan bersertifikat pendidik di wilayah Malang Raya. Instrumen penelitian meliputi kuesioner (angket) dan pedoman wawancara. Hasil penelitian menunjukkan bahwa pemberlakuan Undang-Undang Guru dan Dosen (UU Nomor 14 Tahun 2005) yang disertai pemberian tunjangan profesi sejatinya memberikan harapan besar dalam mendorong minat guru untuk terus mengembangkan profesionalitasnya. Namun, temuan penelitian menunjukkan kondisi yang berbeda. Tingkat pengembangan profesionalitas berkelanjutan guru bersertifikat pendidik di SMK rumpun teknologi se-Malang Raya …

Analisis Variasi Genetik Varian Jati Arboretum Dengan Penanda Mikrosatelit, Imas Cintamulya

Jurnal Pendidikan Sains

Seleksi tanaman jati untuk memperoleh sifat unggul tidak cukup hanya melalui penanda morfologi, tetapi juga perlu menggunakan penanda molekuler berdasarkan polimorfisme DNA. Oleh karena itu, perlu dilakukan kajian tanaman jati dari segi genetik pada level DNA untuk melihat variasi genetik. Informasi tentang variasi genetik jati diperlukan dalam pengadaan bibit untuk pembangunan hutan tanaman industri, dengan tujuan mencegah inbreeding dan mendukung upaya konservasi. Penelitian ini bertujuan untuk menganalisis variasi genetik varian jati arboretum menggunakan penanda molekuler mikrosatelit serta menyusun buku pengayaan kajian dasar-dasar molekuler tumbuhan, khususnya penanda mikrosatelit, dalam menganalisis variasi genetik varian jati arboretum yang berkualitas. Langkah-langkah penelitian meliputi isolasi …

Pembelajaran Kooperatif Tai Dan Game Puzzle Dalam Meningkatkan Motivasi Belajar Dan Pemahaman Konsep Matematika, Any Herawati

Jurnal Pendidikan Sains

Penelitian ini mendeskripsikan rancangan dan pelaksanaan pembelajaran kooperatif Team Assisted Individualized (TAI) dan game puzzle dalam meningkatkan motivasi belajar serta pemahaman konsep fungsi komposisi dan fungsi invers di SMA Negeri 3 Malang. Penelitian ini merupakan penelitian tindakan kelas dengan pendekatan mix research, yang dilaksanakan dalam tiga siklus. Subjek penelitian adalah siswa kelas XI IPA 1 semester genap tahun pelajaran 2011/2012 sebanyak 33 siswa, terdiri atas 13 siswa laki-laki dan 20 siswa perempuan. Data yang dikumpulkan meliputi motivasi belajar dan pemahaman konsep matematika siswa. Hasil penelitian menunjukkan bahwa pembelajaran kooperatif TAI dan game puzzle mampu meningkatkan motivasi belajar dan pemahaman konsep. …

Persepsi Pengelola Terhadap Peran Sistem Informasi Manajemen (Sim) Berbasis Teknologi Informasi (Ti) Dalam Pengelolaan Administrasi Sekolah Menengah Kejuruan Kota Mojokerto, Tri Wahjoedi Hidajat

Jurnal Pendidikan Sains

Peran sistem informasi manajemen (SIM) berbasis teknologi informasi sangat penting dalam pengelolaan sekolah untuk meningkatkan kualitas pelayanan, proses, dan prestasi belajar siswa. Oleh karena itu, penelitian ini bertujuan untuk mengungkap dan mendeskripsikan persepsi pengelola terhadap peran SIM berbasis TI dalam pengelolaan administrasi SMK di Kota Mojokerto. Penelitian ini menggunakan rancangan deskriptif kuantitatif dan dilaksanakan pada sembilan SMK di Kota Mojokerto dengan 45 pengelola administrasi akademik sebagai populasi. Teknik pengambilan sampel yang digunakan adalah sampel jenuh, yaitu seluruh populasi dijadikan sampel. Hasil penelitian menunjukkan bahwa: (1) secara umum, persepsi pengelola terhadap peran SIM berbasis TI dalam pengelolaan administrasi SMK tergolong penting, …

Integrasi Pendidikan Karakter Melalui Inkuiri Dengan Lesson Study Dalam Pembelajaran Biologi Untuk Meningkatkan Sikap Ilmiah Dan Hasil Belajar Kognitif Siswa Kelas Vii Smpn I Singosari, Elly Lailatul Budur

Jurnal Pendidikan Sains

Pembelajaran inkuiri memungkinkan siswa terlibat secara aktif dalam proses berpikir dan menemukan konsep yang dipelajarinya. Pengetahuan dan keterampilan yang diperoleh siswa diharapkan bukan sekadar hasil menghafal fakta, melainkan hasil dari proses penemuan secara mandiri. Hasil pengamatan awal menunjukkan bahwa siswa SMP Negeri 1 Singosari masih cenderung menghafal materi pembelajaran sehingga keterampilan proses dan sikap ilmiah belum berkembang secara optimal. Selain itu, karakter siswa sebagaimana diamanatkan dalam tujuan pendidikan nasional belum sepenuhnya tercapai. Penelitian ini bertujuan untuk meningkatkan sikap ilmiah dan hasil belajar kognitif siswa melalui integrasi pendidikan karakter dengan metode inkuiri terbimbing berbasis lesson study pada siswa kelas VII SMP …

Penerapan Pembelajaran Inkuiri Terbimbing Berbasis Laboratorium Untuk Meningkatkan Keterampilan Proses Dan Hasil Belajar Ipa Siswa Kelas Viii-4 Di Smpn 1 Probolinggo, Karyatin Karyatin

Jurnal Pendidikan Sains

Penelitian ini bertujuan untuk mendeskripsikan keterlaksanaan pembelajaran inkuiri terbimbing berbasis kegiatan laboratorium dalam meningkatkan keterampilan proses sains dan hasil belajar kognitif IPA (biologi) siswa. Deskripsi keterlaksanaan pembelajaran diperoleh melalui identifikasi permasalahan yang muncul selama proses pembelajaran di kelas, yang selanjutnya dianalisis untuk menemukan solusi berdasarkan data empiris di lapangan. Penelitian ini juga berupaya mengungkap permasalahan pembelajaran secara menyeluruh dan kontekstual dengan menempatkan peneliti sebagai instrumen kunci. Pendekatan yang digunakan adalah kualitatif dengan jenis penelitian tindakan kelas (PTK) yang dilaksanakan dalam dua siklus. Setiap siklus terdiri atas empat pertemuan dengan alokasi waktu 2 × 40 menit per pertemuan. Teknik pengumpulan data …

Interspecific Variation In Leaf-Level Biogenic Emissions Of The Bambuseae, Andrea Natalie Melnychenko

Dissertations and Theses

Plants emit a diverse range of biogenic volatile organic compounds (BVOCs) into the atmosphere, of which isoprene is the most abundantly emitted. Isoprene significantly affects biological and atmospheric processes, but the range of isoprene and BVOCs present in bamboos has not been well characterized. In this thesis I explore the range of isoprene emission found in bamboos and relate it to plant morphological and physiological characteristics. In addition, I measure and relate the entire suite of BVOCs present in the bamboos to their fundamental isoprene emission rate.

Interspecific variation in isoprene emission documented in a comprehensive survey of bamboos. Two …

Global Dynamics Of A Water-Borne Disease Model With Multiple Transmission Pathways, Prasanta K. Mondal, T. K. Kar

Applications and Applied Mathematics: An International Journal (AAM)

We propose and analyze a water born disease model introducing water-to-person and person-toperson transmission and saturated incidence. The disease-free equilibrium and the existence criterion of endemic equilibrium are investigated. Trans critical bifurcation at the disease-free equilibrium is obtained when the basic reproductive number is one. The local stability of both the equilibria is shown and a Lyapunov functional approach is also applied to explore the global stability of the system around the equilibria. We display the effects of pathogen contaminated water and infection through contact on the system dynamics in the absence of person-to-person contact as well as in the …

Biochemical, Nutrient And Inhibitory Characteristics Of Streptomyces Cultured From A Hypersaline Estuary, The Laguna Madre (Texas), Luis E. Espinoza, Anita L. Davelos Baines, Kristine L. Lowe

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Streptomyces are common soil bacteria that produce secondary metabolites, including several antibiotics; however, the characteristics of marine Streptomyces are largely unknown. Sediment samples were taken from 3 sites in the Laguna Madre to isolate marine Streptomyces. Sediment was diluted, spread onto synthetic seawater media to estimate the total bacterial density of the samples and spread onto starch casein agar to isolate Streptomyces. Isolated Streptomyces were tested for salinity tolerance and optimal growth pH. Isolates were assayed using API 20E® test strips and BIOLOG™ plates to construct biochemical profiles and assess nutrient utilization abilities of the bacteria, respectively. Individual Streptomyces were …

Factors Influencing Nest Site Selection By Wood Turtles (Glyptemys Insculpta) In An Altered Forest Landscape, Ellery Ruther

Theses & Honors Papers

There have been many studies concerning wood turtle (Glyptemys insculpta) nest site selection, including studies that evaluate nest site conditions when stream sand banks are not available. However, because of the unique landscape at our study site (high gradient, first order streams) and rapidly diminishing wood turtle populations in Virginia, I am evaluating wood turtle nest site selection. Nine physiographic and vegetative characteristics from nest, positive, negative-one and negative-two control locations were evaluated using binomial generalized linear models and then best fit models were chosen using Akaike's Information Criterion (AIC). It was found that in lieu of typical stream …

Influence Of Genetic Variation On Birth Defects In Caenorhabditis Elegans, Daniel Robert Kepple

Renée Crown University Honors Thesis Projects - All

In my Renee Crown Honors Capstone project, I studied how genetic variation influences birth defects that cause death in C. elegans embryos. I performed high-throughput hatching assay experiments of recombinant inbred advance intercross lines of C. elegans. These lines are genetically distinct from each other. I found significant variation in birth defects causing embryo death in these recombinant inbred advanced intercross lines. My results give evidence that gene interaction may play a significant role in causing birth defects resulting in death. My data also provides a starting point for studies making statistical arguments linking these birth defects to specific …

Study Of Genes Relating To Degradation Of Aromatic Compounds And Carbon Metabolism In Mycobacterium Sp. Strain Kms, Chun Zhang

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Polycyclic aromatic hydrocarbons are produced from incomplete combustion of organic materials by human or natural activities. These polycyclic aromatic hydrocarbons are classified as pollutants because of their toxic, mutagenic, and carcinogenic characteristics. Mycobacterium sp. strain KMS, isolated from a contaminated soil, grows on the model polycyclic aromatic hydrocarbon, pyrene, with its degradation to water and carbon dioxide. This study locates genes on the chromosome and plasmids of isolate KMS relating to pyrene degradation, elucidates the influence of other carbon sources available in the habitats of isolate KMS on degradation of pyrene, and deduces possible metabolic pathways used by isolate …

The Use Of P53-Derived Stapled Peptides As Affinity Isolation Reagents, Kathryn Margaret Headley

Renée Crown University Honors Thesis Projects - All

The transcription factor p53 can induce apoptosis and cell cycle arrest in response to cellular distress. Cancer cells often display increased cell survival. In most cases, this is due to a p53-related defect, such as mutation, deletion, degradation, or sequestration. HDM2 and HDMX are homologous proteins that regulate the function of p53, and their over-expression can lead to an ineffective p53 response. Various inhibitors, including hydrocarbon stabilized alpha-helices of p53 (SAH-p53s), have been developed to target HDM2 and HDMX and restore functionality to the p53 pathway. It has been recently found that SAH-p53 factors also elicit cell death responses in …

Characterization Of Dap2 (Defense-­‐Associated Aspartic Protease-­‐2) In Arabidopsis Thaliana And Determining Its Role In Plant Defense Responses, Kemardo Kitaro Henry

Renée Crown University Honors Thesis Projects - All

Plants defend themselves from invading pathogens by coordinating activity of several plant defense-­‐associated genes. Defense-­‐Associated Aspartic Protease-­‐1 (DAP1) gene of Arabidopsis encodes for an atypical aspartic protease with a putative proteolytic activity. The DAP1 is a negative regulator of plant immunity and the transgenic plants ectopically expressing this genes support pathogen growth and pathogenicity. The Arabidopsis genome has another putative protese that has ~75% homology to DAP1 present in close proximity and therefore was named DAP2. Here, I describe the role of the DAP2 gene in plant defense responses. Two independent knockout dap2 mutants are found to be more susceptible …

Vitamin B12-Based Bioconjugate Probes For In Vitro And In Vivo Imaging, Anna Kahkoska

Renée Crown University Honors Thesis Projects - All

Cancer is the second leading cause of death in the United States. This year, an estimated 577,190 Americans will die as a result of this family of diseases. Finding cancer at its most treatable stage gives patients the greatest chance of recovery; novel imaging agents that target primary and metastasized tumors offer hope for improved prognoses in the future. Based on the hypothesis that vitamin B12 (B12) and its association with specific transport proteins could offer selective access to cancer cell lines, a series of B12-based imaging agents were synthesized, characterized, and assayed for both in vitro and in vivo …

Dispersal Ecology Of Desert Mosses Along Gradients Of Elevation, Wildfire Disturbance And Local Niche, Robert Joseph Smith

UNLV Theses, Dissertations, Professional Papers, and Capstones

Much of the variation in plant communities can be explained by the dispersal of individuals across landscapes, an ecological process that contributes to clinal variation, post-disturbance recovery and habitat occupancy. The role of dispersal is of particular concern for Mojave Desert plant communities that may not be able to tolerate recent departures from historical fire regimes. The aim of this thesis was to infer how dispersal is reflected by patterns of diversity in disturbed and undisturbed bryophyte communities in the Spring Mountains of southern Nevada. Chapter 2 presents an examination of sub-surface bryophyte communities (propagule "soil-banks") along a 1400 m …

Effects Of Environmental Variables On The Reproduction Of Quagga Mussels (Dreissena Rostriformis Bugensis) In Lake Mead, Nv/Az, Richard Steven Ianniello

UNLV Theses, Dissertations, Professional Papers, and Capstones

In 2007, quagga mussels (Dreissena rostriformis bugensis) were found in Lake Mead and have spread downstream on the Colorado River and to other lakes and reservoirs in the Southwestern United States. The quagga mussel's extremely quick colonization of Lake Mead and annual veliger abundance trends provide evidence that the quagga mussels in the Southwest have different reproductive behavior than in previous habitats. This study is one of the first to specifically examine quagga mussel reproduction in the Southwest and examines how quagga mussel reproduction varies at sites known to have different temperatures and other environmental variables resulting from the input …

Volume 05, Ian Karamarkovich, Jessica Cox, Kyle Fowlkes, Allison Pawlowski, Kaitlin Major, Carrie Dunham, Kelsey Scheitlin, Kathryn Grayson, Ashley Johnson, Jennifer Nehrt, Kelsey Stolzenbach, Kristin Mcquarrie, Sara Nelson, Melisa Michelle, Jessica Sudlow, Perry Bason, Danielle Dmuchawski, Mariah Asbell, Matthew Sakach, Timothy Smith Jr., Annaliese Troxell, T. Dane Summerell, Sarah Ganrude, Malina Rutherford, Hannah Hopper, John Berry Jr., James Early, Colleen Festa, Chelsea D. Taylor, Michelle Maddox, Kaitlyn Smith, Sarah Schu, Cabell Edmunds, Katherine Grayson, Kayla Tornai

Incite: The Journal of Undergraduate Scholarship

Introduction from Dean Dr. Charles Ross

The Tallis House as an Extension of Emily Tallis in McEwan's Atonement by Ian Karamarkovich

Graphic Design by Jessica Cox

Graphic Design by Kyle Fowlkes

Graphic Design by Allison Pawlowski

Incorporating Original Research in The Classroom: A Case Study Analyzing the Influence of the Chesapeake Bay on Local Temperatures by Kaitlin Major, Carrie Dunham and Dr. Kelsey Scheitlin

Graphic Design by Kathryn Grayson

Graphic Design by Ashley Johnson

Facing the Music: Environmental Impact Assessment of Building A Concert Hall on North Campus by Jennifer Nehrt, Kelsey Stolzenbach And Dr. Kelsey Scheitlin

Art by Kristin …

Dna Damage Repair Genes Controlling Human Papillomavirus (Hpv) Episome Levels Under Conditions Of Stability And Extreme Instability, Terri Edwards, Thomas Vidmar, Kevin Koeller, James Bashkin, Chris Fisher

Chemistry & Biochemistry Faculty Works

DNA damage response (DDR) genes and pathways controlling the stability of HPV episomal DNA are reported here. We set out to understand the mechanism by which a DNA-binding, N-methylpyrrole-imidazole hairpin polyamide (PA25) acts to cause the dramatic loss of HPV DNA from cells. Southern blots revealed that PA25 alters HPV episomes within 5 hours of treatment. Gene expression arrays identified numerous DDR genes that were specifically altered in HPV16 episome-containing cells (W12E) by PA25, but not in HPV-negative (C33A) cells or in cells with integrated HPV16 (SiHa). A siRNA screen of 240 DDR genes was then conducted to identify enhancers …