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Articles 181 - 210 of 1987
Full-Text Articles in Life Sciences
Ornithofauna Diversity Of Tehsil Pakpattan, Punjab, Pakistan, Muhammad Amir Sial
Ornithofauna Diversity Of Tehsil Pakpattan, Punjab, Pakistan, Muhammad Amir Sial
Journal of Bioresource Management
Tehsil Pakpattan is situated in the Doab region of Punjab, Pakistan, along the Sutlej River. The present study aimed to evaluate the avian biodiversity of Tehsil Pakpattan. The study included the evaluation of species diversity, IUCN Red List status, migratory description, and feeding habits of the bird populations of Tehsil Pakpattan. Regular surveys were conducted at ten different localities in Tehsil Pakpattan, including Islam Colony, Kanipur, Farid Kot, 14 S/P, Chak Khagga, Musewal, 8 S/P, Noorpur, Green Town, and Bonga Niaz Khan, from January 2022 to April 2023. The Shannon‒Wiener diversity index value (R' = 3.41) indicated the notable diversity …
A Review On Bioremediation Of Heavy Metals And Hydrocarbons Through Plant Growth-Promoting Bacteria And Composting, Hafsa Saleem, Hadia Farooq, Rimsha Mazhar, Sadaf Shakil, Sahar Fazal
A Review On Bioremediation Of Heavy Metals And Hydrocarbons Through Plant Growth-Promoting Bacteria And Composting, Hafsa Saleem, Hadia Farooq, Rimsha Mazhar, Sadaf Shakil, Sahar Fazal
Journal of Bioresource Management
Soil is an important ecosystem component; it serves as a habitat for many microscopic organisms that play an important role in the ecosystem's maintenance and crops grown in soil. Unfortunately, human activities have adversely affected not only the environment but also the soil health. Soil has been contaminated with heavy metals hydrocarbons and hydrocarbon-based products that are affecting soil health and the growth of plants. In this review two methods of heavy metal remediation are discussed; one is the role of plant growth-promoting bacteria (PGPB) in the enhancement of phytoremediation and the other is composting. PGPB help plants to grow …
Assessing The Effectiveness Of Copper Oxide Nanoparticles (Cuo-Nps) As Larvicidal Agents Against Aedes Aegypti Larvae In A Laboratory Setup, Muhammad Ahsan Riaz, Ayesha Riaz, Muhammad Asif Mahmood, Muhammad Uzair Mukhtar, Waseem Akram, Ehtisham Arshad, Zaib Un Nisa, Beenish Ijaz, Muhammad Shahid Rasool
Assessing The Effectiveness Of Copper Oxide Nanoparticles (Cuo-Nps) As Larvicidal Agents Against Aedes Aegypti Larvae In A Laboratory Setup, Muhammad Ahsan Riaz, Ayesha Riaz, Muhammad Asif Mahmood, Muhammad Uzair Mukhtar, Waseem Akram, Ehtisham Arshad, Zaib Un Nisa, Beenish Ijaz, Muhammad Shahid Rasool
Journal of Bioresource Management
The control of Aedes aegypti (A. aegypti), the primary vector for dengue virus, requires effective larvicidal agents to target larvae breeding in various water sources. This study aimed to assess the effectiveness of Copper Oxide Nanoparticles (CuO-NPs) as larvicidal agents against A. aegypti larvae in a laboratory setup. Larvae were exposed to CuO-NPs at five contrasting concentrations (0, 5, 10, 20, and 30 mg/l). Twenty-five fourth instar larvae were subjected to each concentration with three replicates and one control with the same number (n=25) of larvae under optimum laboratory conditions. The larval mortality was calculated after 24 hours. …
The Impact Of The Gut-Brain Axis On Alzheimer’S Disease, Elissa Wakim
The Impact Of The Gut-Brain Axis On Alzheimer’S Disease, Elissa Wakim
Best Integrated Writing
Elissa’s review for the Graduate Biomedical Review focuses on the links between the gastrointestinal tract and the brain; the gut-brain axis and the development of Alzheimer’s disease. As a student in the Microbiology and Immunology Masters Program Elissa was particularly interested in the gut microbiota and their connection to neurodegenerative disease. She tidily reviewed the literature and wrote a fascinating and compelling piece of work.
Desalination As A Source Of Freshwater, Jacob Pensky
Desalination As A Source Of Freshwater, Jacob Pensky
Best Integrated Writing
Jacob Pensky's article deals with technology we use to make saltwater drinkable. Drought-stricken coastal communities need desalination plants, especially as Earth's climate warms, but they are expensive and energy-intensive. This article describes ways to reduce the environmental and monetary costs.
Best Integrated Writing Spring 2024 - Complete Edition, Wright State University School Of Humanities And Cultural Studies, Kristie Mckiernan, Tracy Smith
Best Integrated Writing Spring 2024 - Complete Edition, Wright State University School Of Humanities And Cultural Studies, Kristie Mckiernan, Tracy Smith
Best Integrated Writing
Best Integrated Writing includes excellent student writing from Integrated Writing courses taught at Wright State University. This is the first issue after a 5 year hiatus.
Pedigree Analysis Of Congenital Stationary Night Blindness And Surveillance Of Related Problems In The Area Of Depalpur, Okara-Pakistan, Muhammad Abdullah, Muhammad Sajjad Sarwar, Muhammad Rizwan, Muhammad Iqbal Usama, Hamza Zulfiqar, Muhammad Wajid, Saira Ashfaq
Pedigree Analysis Of Congenital Stationary Night Blindness And Surveillance Of Related Problems In The Area Of Depalpur, Okara-Pakistan, Muhammad Abdullah, Muhammad Sajjad Sarwar, Muhammad Rizwan, Muhammad Iqbal Usama, Hamza Zulfiqar, Muhammad Wajid, Saira Ashfaq
Journal of Bioresource Management
Congenital stationary night blindness (CSNB) is described as a set of inherited, non-progressive retinal conditions in which the rod pathway is primarily affected, resulting in difficulty adapting to low-light situations due to impaired photoreceptor transmission. Objectives of study was to identify patients with CSNB and explore their lifestyle and the impact of CSNB on their daily routines in selected areas. Total seven families having CSNB, belonging to five villages (Abadi Haji Ismaeel, Sunari wala, Tibba, Shamdin, and Chorasta Mian Khan) of Depalpur, district Okara, were investigated in March 2023. The CSNB prevalence was calculated as 2.528 % in all selected …
Necked Keelback Fowlea Schnurrenbergeri (Kramer, 1977) In Northeastern Punjab, Pakistan, Mudassar Basri, Zohaib Nasar
Necked Keelback Fowlea Schnurrenbergeri (Kramer, 1977) In Northeastern Punjab, Pakistan, Mudassar Basri, Zohaib Nasar
Journal of Bioresource Management
The bar-necked keelback snake plays a vital ecological role as a natural pest controller, effectively regulating populations of fish, frogs, and rodents. Through their predatory behavior, they contribute significantly to maintaining ecological balance by managing the numbers of these smaller creatures, thereby contributing to the overall health of ecosystem. We have documented Fowlea schnurrenbergeri in the urban center of Tehsil Zafarwal and Dariyapur village, within Narowal district, Punjab. Previously, Sindh-Thatta represented the southeastern most known locality for this species in Pakistan. This study presents new insights into the distribution range of this less-frequently observed species.
A Review On The Role Of Tomatoes In Pakistan's Agricultural Economy: Challenges And Strategies For White Fly (Bemisa Tabaci: Hemiptera) Management, Muhammad Wahid Khan, Zahid Hussain, Shahid Sattar, Fazal Maula
A Review On The Role Of Tomatoes In Pakistan's Agricultural Economy: Challenges And Strategies For White Fly (Bemisa Tabaci: Hemiptera) Management, Muhammad Wahid Khan, Zahid Hussain, Shahid Sattar, Fazal Maula
Journal of Bioresource Management
The largest sector of Pakistan's economy is agriculture. Tomatoes, considered both vegetables and fruits, are an essential part of the daily diet for people in the economy class as well as those with limited means, with per capita food consumption of 8.00 kg recorded in Pakistan. Tomatoes are a rich source of essential nutrients such as Vitamin C, A, and Iron, and naturally contain Lycopene, known for its antioxidant properties that can help prevent cancer. In Pakistan, tomato crops yield approximately 40 kg per acre, which is below the world average of 4.00 tons per acre. The Pakistan renowned tomato …
Assessment Of The Genotoxic Effect Of Pesticide (Profenophos And Cypermethrin) On Allium Cepa L. Through Comet Assay, Ali Hasnian, Muhammad Rizwan, Hamed Dadkhah-Aghdash ., Zahid Mehmood, Ayesha Iqbal, Zarbab Zulfiqar, Bin Yameen, Hafiz Naveed Anjum, Sohaib Muhammad, Muhammad Luqman, Andleeb Anwar Sardar, Muhammad Umer Farooq
Assessment Of The Genotoxic Effect Of Pesticide (Profenophos And Cypermethrin) On Allium Cepa L. Through Comet Assay, Ali Hasnian, Muhammad Rizwan, Hamed Dadkhah-Aghdash ., Zahid Mehmood, Ayesha Iqbal, Zarbab Zulfiqar, Bin Yameen, Hafiz Naveed Anjum, Sohaib Muhammad, Muhammad Luqman, Andleeb Anwar Sardar, Muhammad Umer Farooq
Journal of Bioresource Management
Pesticides are specially designed to control pests and help in increasing the yield of crops. This study aims to investigate the genotoxic effect of the major ingredients of commonly used pesticides (Profenophos and Cypermethrin) on Allium cepa L. in different regions of the province of Punjab, Pakistan. Profenophos and Cypermethrin pesticides are extensively used by local farmers. Six different dilutions of Profenophos and Cypermethrin pesticide ranging from, 0.5 ml/L, 1 ml/L, 1.5 ml/L, 2 ml/L, 2.5 ml/L and 3.0 ml/L were applied initially on seeds germination. Seeds grown in a 3.0 ml/L concentration showed a lower radical length percentage as …
Unlocking The Promise Of The ″Miracle Tree: A Review On Therapeutic Applications And Phytochemistry Of Moringa Oleifera L., Ali Zeeshan, Mubashrah Munir, Sehrish Sadia
Unlocking The Promise Of The ″Miracle Tree: A Review On Therapeutic Applications And Phytochemistry Of Moringa Oleifera L., Ali Zeeshan, Mubashrah Munir, Sehrish Sadia
Journal of Bioresource Management
Moringa oleifera, commonly known as the "miracle tree", has been used for centuries in traditional medicine and has recently garnered interest from the scientific community for its therapeutic potential. This review summarizes the current knowledge on the phytochemistry, nutritional composition, and medicinal properties of different parts of M. oleifera. The leaves, pods, bark, roots, seeds, and flowers contain various essential nutrients like vitamins, minerals, amino acids, antioxidants, and phytochemicals such as flavonoids, glucosinolates, and phenolic acids. These bioactive compounds confer anti-diabetic, anti-cancer, cardioprotective, anti-inflammatory, antimicrobial, immunomodulatory, anti-venom, and wound healing properties. Extracts and isolates from M. oleifera have shown …
Susceptibility Assessment Of Human–Wildlife Conflict In Hirpora Wildlife Sanctuary Western Himalayas, Kashmir Using Geospatial Techniques, Tariq Ahmad Bhat, Syed Tanveer, Khursheed Ahmad
Susceptibility Assessment Of Human–Wildlife Conflict In Hirpora Wildlife Sanctuary Western Himalayas, Kashmir Using Geospatial Techniques, Tariq Ahmad Bhat, Syed Tanveer, Khursheed Ahmad
Journal of Bioresource Management
Managing human-wildlife conflict requires a spatial understanding, but this is hindered by a lack of spatially explicit data. The present research was conducted in the Hirpora Wildlife Sanctuary (HWS) in Kashmir, India, with the aim of investigating possible geospatial connections between animal attacks on humans between 2019 and 2021. The patterns and drivers of human-wildlife conflicts around HWS were investigated using spatially-implicit data collected from 2019–2021. There were significant differences in attack patterns across the months, and majority of the attacks occurred outside the park. Most of the attacks occurred within 1 km of the buffer zone forests and croplands. …
Toxicity Of Three Species Of The Solanaceae Family Growing In Algeria Against Culiseta Longiareolata Mosquitos 4th Stage Larvae, Saliha Benhissen, Abdelmaddjid Yagoub Asloum, Nora Belkhiri, Zakaria Hedjouli, Siham Bounadji, Wafa Habbachi, Khellaf Rebbas
Toxicity Of Three Species Of The Solanaceae Family Growing In Algeria Against Culiseta Longiareolata Mosquitos 4th Stage Larvae, Saliha Benhissen, Abdelmaddjid Yagoub Asloum, Nora Belkhiri, Zakaria Hedjouli, Siham Bounadji, Wafa Habbachi, Khellaf Rebbas
Journal of Bioresource Management
Mosquitoes have always been considered a source of harm to humans and animals mainly because they can be vectors of disease. This work represents a study on the effect of aqueous extract of three plants (Hyoscyamus albus, Solanum elaeagnifolium, Solanum nigrum) of the Solanaceae family on the mortality of 4th stage larvae of Culiseta longiareolata larvae. Extract of the high impact is of S. nigrum followed by H. albus and S. elaeagnifolium, respectivley of C. longiareolata larvae.
Biological Significances Of Environmental Pollution In The New Calabar River, Southern Nigeria: A Case Study In Zooplankton Composition, Ibienebo Davies Imachrist, Francis David Sikoki, Philomina Kika, Davies Ibienebo Chris
Biological Significances Of Environmental Pollution In The New Calabar River, Southern Nigeria: A Case Study In Zooplankton Composition, Ibienebo Davies Imachrist, Francis David Sikoki, Philomina Kika, Davies Ibienebo Chris
Journal of Bioresource Management
The study was conducted for three months (May to July 2020), focusing on the physicochemical parameters and zooplankton composition in the Ogbogoro region of the New Calabar River in Nigeria. This investigation was carried out at three distinct monitoring stations. The physicochemical parameters were determined using standard ecological analytic procedures. PAST and SPSS were used for the statistical analysis. The temperature ranged between 26.5 to 33 ºC, salinity (1.23 to 1.86 %), pH (7.4 to 9.62), Total Dissolved Solids (2419 to 5,817 mg/L), conductivity (223.83 to 7,328 μS/cm), turbidity (3.415 to 15.05 NTU) and Dissolved Oxygen (3.8 to 6.8 mg/L). …
Impact Of Infestation Of Flour By Stored Food Pest Insects Ephestia Kuehniella On Quality Flour: Physico-Chemical Analyses, Hadjira Bendjedid, Samira Yezli-Touiker, Asma Taffar, Amina Yezli, Nabila Souileh
Impact Of Infestation Of Flour By Stored Food Pest Insects Ephestia Kuehniella On Quality Flour: Physico-Chemical Analyses, Hadjira Bendjedid, Samira Yezli-Touiker, Asma Taffar, Amina Yezli, Nabila Souileh
Journal of Bioresource Management
The primary reason for significant post-harvest losses globally stems from the infestation of insect pests. These beetles, as they progress through their life cycle, lead to the deterioration of stored food, capable of decimating an entire inventory within a remarkably brief timeframe. Quality control is a system that monitors product quality, assuring and detecting any spoilage of a product, the impact of infestation of flour by pairs of stored food pest insects E. kuehniella on quality flour was evaluated by physicochemical analyses over time. Provoked exposure of 200 g of flour to 5, 10, and 20 couples of Ephestia keuhniella …
Pre And Post Breeding Morphometric Profile Of European Rabbit (Oryctolagus Cuniculus), Rao Zahid Sattar, Rana Manzoor Ahmad, Abdul Majid Khan, Muhammad Altaf, Muhammad Rizwan, Sajjad Yaseen
Pre And Post Breeding Morphometric Profile Of European Rabbit (Oryctolagus Cuniculus), Rao Zahid Sattar, Rana Manzoor Ahmad, Abdul Majid Khan, Muhammad Altaf, Muhammad Rizwan, Sajjad Yaseen
Journal of Bioresource Management
After 1950s, a continuous decline in the population of Oryctolagus cuniculus has urged the IUCN to declare it an endangered species. There is a serious need to take conservational steps for Oryctolagus cuniculus breeds by research work on their different morphological and physiological aspects. The current study evaluates the growth of European rabbit through morphometric profile at pre breeding, post 1st breeding and post 2nd breeding stages in order to find out the growth trends of the European rabbits at different breeding stages. The studied sample comprised of 42 pairs for each breed (New Zealand White and American …
Usage Of Almond And Thyme Oils For The Enhancement Of Shelf Life Of Different Fish Species, Aneeza Kanwal, Roheela Yasmeen, Saima Nazir, Shumaila Usman, Bushra Nisar Khan
Usage Of Almond And Thyme Oils For The Enhancement Of Shelf Life Of Different Fish Species, Aneeza Kanwal, Roheela Yasmeen, Saima Nazir, Shumaila Usman, Bushra Nisar Khan
Journal of Bioresource Management
Fish is an important source of protein for millions of people around the globe and it's often a healthier option compared to some other meats. However, the fish industry is facing a storage challenge in the form of rapid spoilage and deterioration of freshness due to bacterial growth and enzymatic activity. The usage of oils in fish can enhance shelf life by creating a protective barrier. This research was designed to see the effects of thyme and almond oil on nutritional profile and shelf life of fish. The three fish species rohu (Labeo rohita), Mali (Wallago attu) …
A Review On Role Of Bacillus Species In Bio-Calcification: A Way Forward In Carbonate Precipitation, Ardil Bin Mansoor, Sheema Yousaf, Amna Gulzar, Ramsha Iqbal, Aisha Waheed Qurashi
A Review On Role Of Bacillus Species In Bio-Calcification: A Way Forward In Carbonate Precipitation, Ardil Bin Mansoor, Sheema Yousaf, Amna Gulzar, Ramsha Iqbal, Aisha Waheed Qurashi
Journal of Bioresource Management
Bio-calcification, also known as microbiologically induced calcite precipitation, is a phenomenon involving the activity of the enzyme urease. A large number of soil microorganism exhibit urease-producing ability. The main purpose of this review article is to signify the calcium carbonate bio-precipitation by Bacillus species including Lysinibacillus sphaericus and Bacillus subtilis. They both precipitated calcite and the shape and size depending on the external and internal conditions like the type of culture medium and the bacterial strains that were used. The research group increased attentions toward MICP (microbial-induced carbonated precipitation) because of its eco-friendly application. Different bacterial strains had been …
Sarin-Induced Neuroinflammation In Mouse Brain Is Attenuated By The Caspase Inhibitor Q-Vd-Oph, Ekta J. Shah, William C. Grunwald Jr., Teresa L. Garrett, Thomas L. Brown, David R. Cool
Sarin-Induced Neuroinflammation In Mouse Brain Is Attenuated By The Caspase Inhibitor Q-Vd-Oph, Ekta J. Shah, William C. Grunwald Jr., Teresa L. Garrett, Thomas L. Brown, David R. Cool
Neuroscience, Cell Biology & Physiology Faculty Publications
Organophosphates cause hyperstimulation of the central nervous system, leading to extended seizures, convulsions, and brain damage. Sarin is a highly toxic organophosphate nerve agent that has been employed in several terrorist attacks. The prolonged toxicity of sarin may be enhanced by the neuroinflammatory response initiated by the inflammasome, caspase involvement, and generation/release of proinflammatory cytokines. Since neurodegeneration and neuroinflammation are prevalent in sarin-exposed animals, we were interested in evaluating the capacity of quinolyl-valyl-O-methylaspartyl-[-2,6-difluorophenoxy]-methyl ketone (Q-VD-OPh), a pan caspase inhibitor to attenuate neuroinflammation following sarin exposure. To test this hypothesis, sarin-exposed C57BL/6 mice were treated with Q-VD-OPh or negative control quinolyl-valyl-O-methylglutamyl-[-2,6-difluorophenoxy]-methyl …
The Influence Of Abiotic Stress And Cultivar Variation On Plant Defenses And Resistance To Emerald Ash Borer (Agrilus Planipennis) In Cultivated Olive (Olea Spp), Idris B. Elesin
Browse all Theses and Dissertations
Emerald ash borer (EAB), Agrilus planipennis, is an invasive pest that significantly impacts olive trees (Olea europaea). This study aimed to assess the role of abiotic stress factors such as drought and salinity in influencing plant defenses and resistance to EAB, while also examining cultivar variation in resistance. The study specifically aimed to address: (1) What effects do varying degrees of abiotic stress (drought, salinity) have on olive trees' antioxidant and peroxidase activity in olive tree? (2) Do distinct olive cultivars exhibit varying levels of resistance to EAB under various stressors? We used a controlled experimental design with two stress …
Characterization Of The Hydroxyurea-Induced Cell Elongation Phenotype In Fission Yeast Ssb1-20 Mutant, Yeseswi Archana Guduri
Characterization Of The Hydroxyurea-Induced Cell Elongation Phenotype In Fission Yeast Ssb1-20 Mutant, Yeseswi Archana Guduri
Browse all Theses and Dissertations
Eukaryotic SSB, also known as replication protein A (RPA), is a single-stranded DNA binding protein that is highly conserved in eukaryotes. It is essential in multiple cellular functions such as DNA replication, repair, recombination, and cell cycle checkpoint signaling. Studying SSB’s or RPA’s checkpoint functions in cells is challenging due to its crucial role in cell survival. Exploring this possibility, we performed an extensive genetic screening of ssb1, which encodes the largest subunit of RPA, looking for nonlethal mutants that lack the checkpoint function. This screen has identified 25 primary mutants that are sensitive to genotoxins namely HU and MMS. …
Long-Read Mdm4 Isoform Sequencing Reveals Aberrant Isoform Landscape In Metastatic Melanomas, Nehaal Rooha Patrick
Long-Read Mdm4 Isoform Sequencing Reveals Aberrant Isoform Landscape In Metastatic Melanomas, Nehaal Rooha Patrick
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The changes in splicing of MDM4 in human melanomagenesis are critical to p53 activity and represent potential therapeutic targets. Genomic characteristics of melanoma and precursor lesions, such as copy number variation and gene expression, have been investigated in detail. However, there has never been a detailed survey of splicing changes that occur during melanomagenesis. Splicing changes can be a very early event in melanoma tumor progression, with characteristic changes in the p53 pathway already in place in early nevi. MDM4 is upregulated in a strong majority of melanoma cases and has been described as a “key therapeutic target in cutaneous …
Mechanosensory Encoding In Ex Vivo Muscle–Nerve Preparations, Stephen N. Housley, Evelyn A. Gardolinski, Paul Nardelli, J'Ana Reed, Mark M. Rich, Timothy C. Cope
Mechanosensory Encoding In Ex Vivo Muscle–Nerve Preparations, Stephen N. Housley, Evelyn A. Gardolinski, Paul Nardelli, J'Ana Reed, Mark M. Rich, Timothy C. Cope
Neuroscience, Cell Biology & Physiology Faculty Publications
Our objective was to evaluate an ex vivo muscle-nerve preparation used to study mechanosensory signalling by low threshold mechanosensory receptors (LTMRs). Specifically, we aimed to assess how well the ex vivo preparation represents in vivo firing behaviours of the three major LTMR subtypes of muscle primary sensory afferents, namely type Ia and II muscle spindle (MS) afferents and type Ib tendon organ afferents. Using published procedures for ex vivo study of LTMRs in mouse hindlimb muscles, we replicated earlier reports on afferent firing in response to conventional stretch paradigms applied to non-contracting, that is passive, muscle. Relative to in vivo …
A Systematic Study Of Freezing Behavior In Earthworms In Response To Auditory And Vibratory Stimuli, Navjot Singh, A. Burton, Dragana Ivkovich Claflin
A Systematic Study Of Freezing Behavior In Earthworms In Response To Auditory And Vibratory Stimuli, Navjot Singh, A. Burton, Dragana Ivkovich Claflin
Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials
This study examined the parameters needed to reliably induce a freezing fear response to a predator-like auditory stimulus in the earthworm species Eisenia Fetida. Previous work from our lab found that a grunting noise was more reliable in causing freezing compared to a mole sound, i.e. artificial versus natural predators of E. Fetida (Worthen et al., 2024). In the present study, 8 amplitude levels of grunting sound were presented in either serial or random order. The speaker location was varied so that it either did or did not touch the apparatus, thus producing a mechanical vibration in addition to the …
The Physiological And Behavioral Effects Of A Centrally Administered Oxytocin Receptor Antagonist On Maternal Buffering In Infant Guinea Pigs, Kendra A. Carter
The Physiological And Behavioral Effects Of A Centrally Administered Oxytocin Receptor Antagonist On Maternal Buffering In Infant Guinea Pigs, Kendra A. Carter
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This study investigates the role of endogenous oxytocin (OT) in maternal buffering of infant stress responses in guinea pigs. Infants received intracerebroventricular infusion of an oxytocin receptor antagonist (OTA) or artificial cerebrospinal fluid (aCSF) immediately before being placed with the mother in a novel environment for 60 minutes. Blood cortisol levels and behavioral responses, including vocalizations and crouching, were measured throughout the testing period. Results indicate only a significant effect of time, with cortisol levels increasing with time spent in the novel environment. Otherwise, no significant differences were observed either physiologically or behaviorally between aCSF and OTA conditions. This study …
What A Waste: Nitrogen Runoff And Rates In The Maumee River (Ohio, Usa), Ryanne Antonette Cimatu
What A Waste: Nitrogen Runoff And Rates In The Maumee River (Ohio, Usa), Ryanne Antonette Cimatu
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Excess anthropogenic nitrogen (N), primarily from agricultural field fertilization, causes nutrient runoff that stimulates harmful algal blooms (HABs) in western Lake Erie. As a critical tributary to Lake Erie, nutrient loading from the Maumee River drives the intensity of the annual summer HABs in the western basin. Knowledge gaps around rates of N transformations in the Maumee River currently hinder the calibration of in-river parameters in Soil and Water Assessment Tool (SWAT) models for the Maumee watershed. To address these gaps, this research quantified rates of ammonium uptake, ammonium remineralization, nitrification, and bacterial respiration alongside physicochemical parameters of the river. …
The Organophosphate Malathion Underlies Locomotor Performance Changes And Motoneuron Morphological Alterations In Sprague Dawley Rats, Kaitlyn Marie Miller
The Organophosphate Malathion Underlies Locomotor Performance Changes And Motoneuron Morphological Alterations In Sprague Dawley Rats, Kaitlyn Marie Miller
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Organophosphates are known neurotoxicants; however, they remain in use as flame retardants and are heavily used as pesticides. Malathion is an organophosphate insecticide commonly used in the United States since 1956. Despite known neurobehavioral impacts, there is little data available as to how repeated, occupational like, malathion exposures impact locomotion and the structure of motoneurons. We hypothesized that low-level repeated exposure to malathion would result in motor function deficits with anatomical alterations in the alpha-motoneurons (MN) consistent with neurodegeneration. Also, we hypothesized that galantamine would be neuroprotective against the effects of malathion. To test our hypothesis, we exposed male and …
Characterization Of Cisplatin-Dna Adduct Release From Cancerous And Non-Cancerous Cell Lines, Aleena Alex
Characterization Of Cisplatin-Dna Adduct Release From Cancerous And Non-Cancerous Cell Lines, Aleena Alex
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Cisplatin is an effective chemotherapeutic agent that is used to treat lung, breast, esophageal, ovarian, and pancreatic cancers. Despite being effective in treating a wide variety of cancer types, its cytotoxicity to off-target healthy tissues restricts its therapeutic application. The platinum atom of cisplatin interacts with DNA and results in the formation of inter-and intra-strand crosslinks, which are often referred to as DNA adducts. These adducts are mutagenic and potentially lethal to cells. The sole pathway for cells to excise intra-strand cisplatin-DNA adducts from the genome is through nucleotide excision repair. The fate of unrepaired DNA adducts is not understood …
The Role Of Suc22-S239f Mutation In Sensitizing Fission Yeast To The Replication Stress Induced By Hydroxyurea, Kajal Davi
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Genetic mutations can significantly impact the cell’s susceptibility to environmental stress. The fission yeast Schizosaccharomyces pombe is an established eukaryotic model for studying the cellular responses to various environmental stresses. This work investigated a missense mutation (S239F) identified in Suc22, the small subunit of the ribonucleotide reductase (RNR). RNR is an essential enzyme for the biosynthesis of dNTPs required for DNA replication and repair. We found that the suc22-S239F mutation increases the susceptibility to the replication stress induced by hydroxyurea (HU), not the DNA-damaging agents such as UV, methyl methanesulfate, and CPT. HU is a drug commonly used in laboratories …
Investigating Calcium Levels During Excitation-Contraction Coupling In Model Huntington's Disease Skeletal Muscle, Pooneh Hajmirza Mohammadi Kamalabadi
Investigating Calcium Levels During Excitation-Contraction Coupling In Model Huntington's Disease Skeletal Muscle, Pooneh Hajmirza Mohammadi Kamalabadi
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One of the less studied aspects of Huntington’s disease (HD) is its impact on skeletal muscle function. Recent studies have suggested that HD patients exhibit altered muscle function and reduced muscle strength, which may be related to defects in Ca2+ handling during excitation-contraction coupling (ECC). However, the underlying mechanisms of these alterations remain poorly understood. This study aims to determine if the myoplasmic Ca2+ during ECC is reduced in late-stage R6/2 (mouse model of HD) muscle fibers compared to age-matched controls during twitch or tetanic stimulation. Such a decrease would help explain weakness or fatigue in the model HD muscle. …