Biomechanical Engineering Commons^™

Modeling Of Patient-Specific Periaortic Mechanics And Pulmonary Artery Hemodynamics Based On Phase-Contrast Magnetic Resonance Imaging Sequences., Johane H. Bracamonte

Theses and Dissertations

Inverse modeling in cardiovascular medicine is a collection of methodologies that can provide non-invasive patient-specific estimations of clinical risk factors using medical imaging as inputs. Its incorporation into clinical practice has the potential to improve diagnosis and treatment planning with low associated risks and costs.

Herein, three different phase contrast magnetic resonance imaging (MRI) modalities were implemented as input data, displacement encoding with stimulated echoes (DENSE MRI) applied, and time-resolved velocity encoding phase-contrast MRI, in 1D and 3D, applied to pulmonary artery (PA) hemodynamics.

A model to account for the effect of periaortic interactions due to static and dynamic structures …

Collision Tracking And Brain Mapping, Carl Russell Iii

The Journal of Purdue Undergraduate Research

No abstract provided.

État Des Récentes Avancées En Matière De Développement De Sièges À Suspension, Subhash Rakheja, Pierre Marcotte, Karim Hamouda, Krishna Dewangan, Darshan Dorugade

Rapports de recherche scientifique

Dans divers secteurs d’activité du Québec, les conducteurs de véhicules sont exposés à des niveaux notables de vibrations globales du corps (VGC) et à des chocs intermittents, associés dans les deux cas à un risque accru de douleurs lombaires et de dégénérescence de la colonne vertébrale. Les sièges à suspension sont largement utilisés pour limiter l'exposition des conducteurs aux VGC. L’efficacité d'un siège à suspension à réduire les vibrations est fortement dépendante de la nature des vibrations du véhicule (amplitude, direction et fréquence). Un siège à suspension ne peut donc offrir une efficacité optimale que lorsque la suspension est mise …

State-Of-The-Art In Recent Developments Concerning Suspension Seats, Subhash Rakheja, Pierre Marcotte, Karim Hamouda, Krishna Dewangan, Darshan Dorugade

Rapports de recherche scientifique

Dans divers secteurs d’activité du Québec, les conducteurs de véhicules sont exposés à des niveaux notables de vibrations globales du corps (VGC) et à des chocs intermittents, associés dans les deux cas à un risque accru de douleurs lombaires et de dégénérescence de la colonne vertébrale. Les sièges à suspension sont largement utilisés pour limiter l'exposition des conducteurs aux VGC. L’efficacité d'un siège à suspension à réduire les vibrations est fortement dépendante de la nature des vibrations du véhicule (amplitude, direction et fréquence). Un siège à suspension ne peut donc offrir une efficacité optimale que lorsque la suspension est mise …

Creating Reel Designs: Reflecting On Arthrogryposis Multiplex Congenita In The Community, Iris Layadi

Purdue Journal of Service-Learning and International Engagement

Because of its extreme rarity, the genetic disease arthrogryposis multiplex congenita (AMC) and the needs of individuals with the diagnosis are often overlooked. AMC refers to the development of nonprogressive contractures in disparate areas of the body and is characterized by decreased flexibility in joints, muscle atrophy, and developmental delays. Colton Darst, a seven-year-old boy from Indianapolis, Indiana, was born with the disorder, and since then, he has undergone numerous surgical interventions and continues to receive orthopedic therapy to reduce his physical limitations. His parents, Michael and Amber Darst, have hopes for him to regain his limbic motion and are …

Numerical Study Of Fully Coupled Fluid-Structure Interaction Of Stented Ureter By Varying The Stent Side-Holes, Erick Martinez, Ben Xu, Jianzhi Li, Yingchen Yang

Mechanical Engineering Faculty Publications

Ureteral stents are a measure used for many medical issues involving urology, such as kidney stones or kidney transplants. The purpose of applying stents is to help relieve the urine flow while the ureter is either blocked or trying to close itself, which creates blockages. These ureteral stents, while necessary, cause pain and discomfort to patients due to them being a solid that moves around inside the patients’ body. The ureter normally moves urine to the bladder through peristaltic forces. Due to the ureter being a hyperelastic material, these peristaltic forces cause the ureter to deform easily, making it necessary …

Development Of Light Actuated Chemical Delivery Platform On A 2-D Array Of Micropore Structure, Hojjat Rostami Azmand, Hojjat Rostami Azmand

Dissertations and Theses

Localized chemical delivery plays an essential role in the fundamental information transfers within biological systems. Thus, the ability to mimic the natural chemical signal modulation would provide significant contributions to understand the functional signaling pathway of biological cells and develop new prosthetic devices for neurological disorders. In this paper, we demonstrate a light-controlled hydrogel platform that can be used for localized chemical delivery in a high spatial resolution. By utilizing the photothermal behavior of graphene-hydrogel composites confined within micron-sized fluidic channels, patterned light illumination creates the parallel and independent actuation of chemical release in a group of fluidic ports. The …

Mechanism For The Unfolding Of The Top7 Protein In Steered Molecular Dynamics Simulations As Revealed By Mutual Information Analysis, Ognjen Perišić, Willy Wriggers

Mechanical & Aerospace Engineering Faculty Publications

We employed mutual information (MI) analysis to detect motions affecting the mechanical resistance of the human-engineered protein Top7. The results are based on the MI analysis of pair contact correlations measured in steered molecular dynamics (SMD) trajectories and their statistical dependence on global unfolding. This study is the first application of the MI analysis to SMD forced unfolding, and we furnish specific SMD recommendations for the utility of parameters and options in the TimeScapes package. The MI analysis provided a global overview of the effect of perturbation on the stability of the protein. We also employed a more conventional trajectory …

Safety Analysis Of Battery-Powered Adaptive Ride-On Toys For Children With Disabilities, Abbey Fraser

UNF Graduate Theses and Dissertations

Modified battery-powered ride-on toy cars, or adaptive ride-on toys, represent novel rehabilitation tools and developmental aids for children with disabilities. Studies have shown that children are benefiting socially and developmentally from their use. However, the use of these toys by children with disabilities potentially poses a risk of injury and it is vitally important to ensure the safe use of these toys, particularly for the benefit of those with developmental challenges.

Within this context, the purpose of the first study was to determine whether modifications to ride-on toys are sufficient to prevent common modes of injury such as falls, passenger …

Nebulizer-Based Systems To Improve Pharmaceutical Aerosol Delivery To The Lungs, Benjamin M. Spence

Theses and Dissertations

Combining vibrating mesh nebulizers with additional new technologies leads to substantial improvements in pharmaceutical aerosol delivery to the lungs across therapeutic administration methods. In this dissertation, streamlined components, aerosol administration synchronization, and/or Excipient Enhanced Growth (EEG) technologies were utilized to develop and test several novel devices and aerosol delivery systems. The first focus of this work was to improve the poor delivery efficiency, e.g., 3.6% of nominal dose (Dugernier et al. 2017), of aerosolized medication administration to adult human subjects concurrent with high flow nasal cannula (HFNC) therapy, a form of continuous-flow non-invasive ventilation (NIV). The developed Low-Volume Mixer-Heater (LVMH) …

In The Pursuit Of Assistance: A Team's Desire To Not Let A Congenital Amputation Get In A Young Boy's Way, Carl Russell Iii, Gavin Loucks, Kirsten Wozniak

Purdue Journal of Service-Learning and International Engagement

EPICS is a service-learning design program run through Purdue University. It strives to teach students design skills through providing for individuals, communities, and organizations in the surrounding area while mirroring engineering industry standards. BME (Biomedical Engineering) is a team within EPICS that strives to serve community partners through biomedical applications. William Sevick is an elementary school student with a congenital arm amputation. William and his family have been working with the BME team for the past three years designing assistive devices with the purpose of improving his actions in daily life such as eating, playing games, and riding his bike.

Surface Modification Of Biomaterials To Reduce Polyethylene Wear In Metal-Polymer Contact / Tan Mean Yee, Tan Mean Yee

Student Works (2020-2029)

This research focus on studying different surface modification (Texturing and DLC coating) on the metal part of TKR (Total knee replacement) in improving UHMWPE (Ultra-high molecular weight polyethylene) wear. TKR was widely being used to relieve knee pain due to osteoarthritis and further restore knee function of patients. Generally, TKR consists of metal femoral component, metal tibial component, and UHMWPE tibial insert. TKR will fail due to various factors over time, however, this study will be focusing on failure cause by loosening. Loosening failure of TKR was mainly caused by wear debris generated during articulation motion, where UHMWPE wear was …

Atv Dynamics And Pediatric Rider Safety, James T. Auxier Ii

Theses and Dissertations--Biomedical Engineering

It has been observed through numerous academic and governmental agency studies that pediatric all-terrain vehicle ridership carries significant risk of injury and death. While no doubt valuable to safety, the post-hoc approach employed in these studies does little to explain the why and how behind the risk factors. Furthermore, there has been no prolonged, widespread, organized, and concerted effort to reconstruct and catalog the details and causes of the large (20,000+) number of ATV-related injuries that occur each year as has been done for road-based motor vehicle accidents. This dissertation takes the opposite approach from a meta-analysis and instead examines …

Enhancement Of The Syncardia Total Artificial Heart For Pediatric Use, Margaret Clark, Madison Marks

Williams Honors College, Honors Research Projects

Pediatric patients with disorders and diseases of the heart have limited options with regards to implantable devices. Many of these implants are ventricular assist devices, which is not always suitable for a patient. Total artificial hearts (TAHs) have supported many adult patients until transplantation, and we believe that they could do the same for pediatric patients. SynCardia has the only Food and Drug Administration (FDA) approved TAH devices. Since SynCardia is the only company with FDA approved TAHs, we decided to modify the design of the SynCardia TAH for use in pediatric patients without compromising the function of the current …

Evaluation Of Control Strategies For Overhead Work Using Electromyography Of Rotator Cuff Muscles, Hossein Motabar

Graduate Theses, Dissertations, and Problem Reports (ETD)

Work-related musculoskeletal disorders (MSDs) of shoulder have a significant impact on overall health and economics in the industrialized nations. Rotator cuff is the most frequently injured region in the shoulder complex. Overhead work is considered as one of the most predominant causes of rotator cuff injuries. The workers in construction, automotive, and aerospace industries are routinely exposed to overhead exertions. Elimination of overhead work is nearly impossible due to various task and technology constraints. Therefore, appropriate intervention strategies based on the engineering and administrative controls opt to be used to prevent the hazardous impact of overhead exertions. The objective of …

System Integration Of C-Arm Robotic Prototype Using Motion Capture Guidance For Accurate Repositioning, Alireza Yazdanshenas

Mechanical Engineering Theses

One of the important surgical tools in spinal surgery is the C-Arm X-ray System. The C-Arm is a large “C” shaped and manually maneuvered arm that provides surgeons and X-ray technicians the ability to take quick quality X-rays during surgery. Because of its five degrees of freedom, the C-Arm can be manually maneuvered around the patient to provide many angles and perspectives, ensuring surgical success.

This system works fine for most surgical procedures but falls short when the C-Arm must be moved out of the way for complicated surgical procedures.

The aim of this thesis is to develop an accurate …

Development Of A Sonically Powered Biodegradable Nanogenerator For Bone Regeneration, Avi Patel

Honors Scholar Theses

Background: Reconstruction of bone fractures and defects remains a big challenge in orthopedic surgery. While regenerative engineering has advanced the field greatly using a combination of biomaterial scaffolds and stem cells, one matter of difficulty is inducing osteogenesis in these cells. Recent works have shown electricity’s ability to promote osteogenesis in stem cell lines when seeded in bone scaffolds; however, typical electrical stimulators are either (a) externally housed and require overcomplex percutaneous wires be connected to the implanted scaffold or (b) implanted non-degradable devices which contain toxic batteries and require invasive removal surgeries.

Objective: Here, we establish a biodegradable, piezoelectric …

How Infant Positioning Impacts Hip Motion And The Associated Implications For Babies With Hip Dysplasia, Lauren Buchele

Biomedical Engineering Undergraduate Honors Theses

Developmental dysplasia of the hip (DDH) refers to a group of disorders, ranging from slight instability (Grades 1-3) to a severe dislocation (Grade 4) of the femoral head from the acetabulum [1]. In order to treat DDH in infants, a reduction procedure and the use of a lower body harness to secure the hip joint as the bones and ligaments re-form properly is typically prescribed. The Pavlik Harness is currently the “gold-standard” orthopedic device used to place hips in proper positioning. However, little research has been reported on the biomechanical affects during use of these device types.

Although the Pavlik …

Efficacy Of Assistive Devices Produced With Additive Manufacturing, James Pierce

UNO Student Research and Creative Activity Fair

Despite the frequency of musculoskeletal injuries such as sprains, broken bones and torn ligaments¹, treatment options are often costly, time-consuming and ill-fitted.^2,3 Additive manufacturing (“3D-printing) allows for the production of highly-customized and inexpensive assistive devices⁴, which suggests potential efficacy in the prescription of splints and casts for musculoskeletal injury.³ In the present study, a parametric, customizable splint/cast was created using a computer-aided design (CAD) package (Fusion 360, Autodesk, San Rafael, CA, USA) and produced with low-cost, desktop 3D printing (Ultimaker 2+ Extended, Ultimaker, Geldermalsen, Netherlands). Fitting of the devices was performed on five healthy …

A Biomimetic Approach To Controlling Restorative Robotics, Matthew T. Boots

Graduate Theses, Dissertations, and Problem Reports (ETD)

Movement is the only way a person can interact with the world around them. When trauma to the neuromuscular systems disrupts the control of movement, quality of life suffers. To restore limb functionality, active robotic interventions and/or rehabilitation are required. Unfortunately, the primary obstacle in a person’s recovery is the limited robustness of the human-machine interfaces. Current systems rely on control approaches that rely on the person to learn how the system works instead of the system being more intuitive and working with the person naturally. My research goal is to design intuitive control mechanisms based on biological processes termed …

Single Arm Recumbent Bicycle, Alexander Borsotti, Ryan Westermann, Sean Liston

Mechanical Engineering

The goal of this report is to outline and cover the scope of work for the Single Arm Recumbent Bicycle Senior Project. The report will give an introduction of the problem, a background of the existing research or products relating to our project, the objectives of our project, our project management plan, our final design, manufacturing, testing, our project management, and final recommendations for improving the final design. The team is being supported by the Quality of Life Program, a non-profit organization that works to improve the lives of those injured in duty while serving our nation.

Up until now, …

Design Of Parallel Robot For Dental Articulation And Its Optimization, Abulimiti Delimulati

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

A dental articulator is a mechanical device used to simulate the relative position and motion between the upper and lower jaw when constructing and testing dental prostheses. Typically, it can be adjusted to approximate patient-specific jaw kinematics in order to analogue the static relationship and specific motions of a patient’s mandible to maxilla. However, the use of dental articulators is essentially a trial-and-error method in order to fine-tune fit and function of a dental prosthesis. Some of the most advanced current dental articulators can reproduce the position and the motion passively; furthermore, dentists need special training for measuring patients’ maxillofacial …

Team Joseph's Bike Trailer, Keely Thompson, Curtis Wathne, Ryan Meinhardt

Mechanical Engineering

This final design report shows the results of this senior project’s design process of creating a custom bike trailer for Team Joseph. As done in the Scope of Work, Preliminary Design report, and Critical Design report, current products, relevant technologies, and American Society for Testing and Materials (ASTM) standards are fully researched and benchmarked to aid in the design selection process. Customer requirements are looked at and developed into engineering specifications. A detailed design was created for CDR to show to Team Joseph, and manufacturing and testing plans were laid out. This final design report adds the final design revisions …

Design & Delivery Of Automated Winston-Lutz Test For Isocentric & Off-Axis Delivery Stability Utilizing Truebeam Developer Mode & Electronic Portal Imaging Device, Mahmoud Mohammad Yaqoub

UNLV Theses, Dissertations, Professional Papers, and Capstones

The uncertainties in treatment delivery cannot be ignored in radiation therapy. Thus, the quality assurance QA tests are very important task of the medical physicist in clinical practice. Assuring the coincidence between the mechanical isocenter of the Linear Accelerator (LINAC) and its radiation beams isocenter is one of the most important qualities need to be tested, and the Winston Lust (WL) test is the

most popular technique to perform this task, especially for the treatment modalities which need high precision in beam delivery such as the stereotactic radiosurgery/stereotactic body radiotherapy (SRS/SBRT). The linear accelerator-based SRS/SBRT is a well-established method in …

Ring And Peg Simulation For Minimally Invasive Surgical Robot, Evan Brown

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Surgical procedures utilizing minimally invasive laparoscopic techniques have shown less complications, better cosmetic results, and less time in the hospital than conventional surgery. These advantages are partially offset by inherent difficulties of the procedures which include an inverted control scheme, instrument clashing, and loss of triangulation. Surgical robots have been designed to overcome the limitations, the Da Vinci being the most widely used. A dexterous in vivo, two-armed robot, designed to enter an insufflated abdomen with a limited insertion profile and expand to perform a variety of operations, has been created as a less expensive, versatile alternative to the Da …

Multi-Scale Fluid Flow Analysis Of The Cardiovascular System, Zaid Mahmood

Doctoral Dissertations and Master's Theses

The hypoplastic left heart syndrome (HLHS) is one of the rarest congenital heart diseases affecting infants. Out of 150 babies born, one baby suffers from congenital heart disease. Furthermore, nine percent out of those suffering from congenital heart disease specifically suffer from hypoplastic left heart syndrome (HLHS). To this end, the Fontan operation which is a procedure to generate a harmonic blood flow in single functioning ventricle patients has been executed to palliate HLHS patients. In this operation, the inferior vena cava (IVC) and the superior vena cava (SVC), carrying the low-oxygenated blood returning from the lower and upper body …

Design And Analysis Of A 3d-Printed, Thermoplastic Elastomer (Tpe) Spring Element For Use In Corrective Hand Orthotics, Kevin Thomas Richardson

Theses and Dissertations--Mechanical and Aerospace Engineering

This thesis proposes an algorithm that determine the geometry of 3D-printed, custom-designed spring element bands made of thermoplastic elastomer (TPE) for use in a wearable orthotic device to aid in the physical therapy of a human hand exhibiting spasticity after stroke. Each finger of the hand is modeled as a mechanical system consisting of a triple-rod pendulum with nonlinear stiffness at each joint and forces applied at the attachment point of each flexor muscle. The system is assumed quasi-static, which leads to a torque balance between the flexor tendons in the hand, joint stiffness and the design force applied to …

Radial And Longitudinal Motion Of The Arterial Wall: Their Relation To Pulsatile Pressure And Flow In The Artery, Dan Wang, Linda Vahala, Zhili Hao

Mechanical & Aerospace Engineering Faculty Publications

The aim of this paper is to analyze the radial and longitudinal motion of the arterial wall in the context of pulsatile pressure and flow, and to understand their physiological implications for the cardiovascular system. A reexamination of the well-established one-dimensional governing equations for axial blood flow in the artery and the constitutive equation for the radial dilation of the arterial wall shows that two waves—a pulsatile pressure wave in the artery and a radial displacement wave in the arterial wall—propagate simultaneously along the arterial tree with the same propagation velocity, explaining why this velocity combines the physical properties and …

Biomechanical Testing Of An Exercise For Strengthening The Proximal Femur., Alyssa Osbourne

Electronic Theses and Dissertations

Based on the principles of cutting edge bone remodeling research, a unique therapeutic exercise device was designed specifically to improve bone quality at the most critical location of the proximal femur prone to fracture: the superior-lateral femoral neck where the fracture first initiates during a fall. The exercise/device is intended to work by inducing enough strain in the bone to stimulate the body’s natural bone remodeling mechanisms to increase bone density in the proximal femur and consequently prevent a fracture from arising if a fall to the side does occur.

In order to test the proposed exercise, experiments simulating the …

Kinematics Of The Lower Extremities During Fundamental Martial Arts Tricking Techniques, Kevin P. Grassie

Honors Scholar Theses

Martial Arts Tricking (MAT) is a relatively new sport that combines martial arts, gymnastics, acrobatics, and breakdancing for the purposes of creating aesthetic and impressive combinations of kicks, flips and twists. It has been growing exponentially through social media and the overall athletic and entertainment communities. The sport is very unique in that the movements, with their blended influences, provide novel ways for athletes to generate and utilize their momentum in a creative way. The results often include off-axis flips and twists, single-leg landings, and complicated yet fluid techniques that easily chain together.

Due to the sport only being a …