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Biochemical and Biomolecular Engineering Commons™
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Articles 61 - 66 of 66
Full-Text Articles in Biochemical and Biomolecular Engineering
A Solid-State Fermentation Scale-Up Of Scopulariopsis Brevicaulis, Timothy Hudak
A Solid-State Fermentation Scale-Up Of Scopulariopsis Brevicaulis, Timothy Hudak
Williams Honors College, Honors Research Projects
Publication to be delayed until October 2023
Extraction Of Melanin From Black Knot Fungus: Optimization And Applications, Amara Davis
Extraction Of Melanin From Black Knot Fungus: Optimization And Applications, Amara Davis
Williams Honors College, Honors Research Projects
The goal of this research project was to optimize the extraction of melanin from black knot fungus and to analyze possible applications of the extracted melanin. An extraction method that was previously created was examined for possible improvements. Improvements that were studied include the elimination of steps in the extraction process while obtaining the same quality of product, examining options for machinery that could be used to increase production rate when moved to a production plant setting, and optimize the concentrations of the raw materials that are used in the extraction for possible reduction of cost without compromising yield or …
Mimicking The Namib Desert Beetle With Hydrophilic And Hydrophobic Surfaces, Tyler Bracewell
Mimicking The Namib Desert Beetle With Hydrophilic And Hydrophobic Surfaces, Tyler Bracewell
Williams Honors College, Honors Research Projects
The Namib Desert beetle, Stenocara gracilipes, condenses fog that rolls in off the west coast of Namibia to provide itself with the water it needs for the day. By lifting its abdomen into the air to collect the water vapor, it condenses on hydrophilic bumps that are about 500μm in diameter and are spaced apart about 500-1500μm. Once the water reaches a critical size, the droplet rolls off the hydrophilic bump and onto the flat hydrophobic surface of the elytra. Since the beetle is angled with its abdomen in the air, the water rolls down to its mouth. A …
Repurposing Human Α-Defensin 6, An Antimicrobial Peptide, As A Beta Amyloid Inhibitor, Eleanor Plaster
Repurposing Human Α-Defensin 6, An Antimicrobial Peptide, As A Beta Amyloid Inhibitor, Eleanor Plaster
Williams Honors College, Honors Research Projects
Amyloid aggregation and microbial infection have been identified as the two main pathological risk factors that can result in amyloid diseases such as Alzheimer’s disease (AD), type II diabetes, and Parkinson’s disease. These two risk factors have been well studied separately, however only targeting one of these risk factors has shown to not be successful in preclinical trials since amyloid diseases are multifactorial. In this study, a new approach has been proposed to determine the effects of an antimicrobial and anti-amyloid aggregation approach by looking at the inhibition abilities of a heterocomplex of human α-defensin 6 (HD-6), whose secondary structure …
Versatile Functionalization Strategy For The Capture Of Antibodies Using Silica Nanoparticles, Sayma Afrin
Versatile Functionalization Strategy For The Capture Of Antibodies Using Silica Nanoparticles, Sayma Afrin
Theses and Dissertations--Chemical and Materials Engineering
In this work, the synthesis of protein-functionalized nonporous silica nanoparticles and their application to capture antibodies was demonstrated. Silica nanoparticles were chosen as they offered particle and pore size tunability, low toxicity, thermal stability, ease of synthesis and ease of surface functionalization. A biotin-streptavidin-biotin bridge was constructed on the surface of the particles and used to attach biotinylated Protein A/G (PAG), which has high affinity for antibodies. The biotin-streptavidin-biotin bridge is hypothesized to orient the PAG in a favorable manner for efficient antibody capture. Nonporous silica nanoparticles (approximately 270 nm in diameter) were synthesized via the Stöber method. Following amine …
Efficient Removal Of Lead Ions From Aqueous Media Using Sustainable Sources On Marine Algae, Hannah Namkoong, Erik Biehler, Gon Namkoong, Tarek M. Abdel-Fattah
Efficient Removal Of Lead Ions From Aqueous Media Using Sustainable Sources On Marine Algae, Hannah Namkoong, Erik Biehler, Gon Namkoong, Tarek M. Abdel-Fattah
Electrical & Computer Engineering Faculty Publications
The goal of this project is to explore a new method to efficiently remove Pb(II) ions from water by processing Undaria pinnatifida into immobilized beads using sodium alginate and calcium chloride. The resulting biosorbent was characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (SEM-EDS). Using immobilized U. pinnatifida, we investigated the effect of various factors on Pb(II) ion removal efficiency such as temperature, pH, ionic strength, time, and underlying biosorption mechanisms. For Pb(II) ion biosorption studies, Pb(II) ion biosorption data were obtained and analyzed using Langmuir and Freundlich adsorption models. It …