Chemical Engineering Commons^™

Protein-Targeted Corona Phase Molecular Recognition, Gili Bisker, Juyao Dong, Hoyoung D. Park, Nicole M. Iverson, Jiyoung Ahn, Justin T. Nelson, Markita P. Landry, Sebastian Kruss, Michael S. Strano

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Corona phase molecular recognition (CoPhMoRe) uses a heteropolymer adsorbed onto and templated by a nanoparticle surface to recognize a specific target analyte. This method has not yet been extended to macromolecular analytes, including proteins. Herein we develop a variant of a CoPhMoRe screening procedure of single-walled carbon nanotubes (SWCNT) and use it against a panel of human blood proteins, revealing a specific corona phase that recognizes fibrinogen with high selectivity. In response to fibrinogen binding, SWCNT fluorescence decreases by >80% at saturation. Sequential binding of the three fibrinogen nodules is suggested by selective fluorescence quenching by isolated sub-domains and validated …

Synthesis And Characterization Of Curcumin Polymer For Application In Radiation Induced Lung Damage, Mark C. Bailey

Theses and Dissertations--Chemical and Materials Engineering

Radiotherapy is used as a primary treatment for many cancers, including lung cancer. Although radiotherapy has proven to be an effective cancer treatment, its use is heavily limited due to the peripheral toxicity to healthy tissue. In this work, the antioxidant, curcumin, was tested as a radioprotectant to reduce radiation damage to healthy cells. Curcumin has been limited in use due to its poor bioavailability. In order to avoid problems associated with free curcumin delivery, curcumin poly(beta-amino ester) (CPBAE) was synthesized.

The first study investigated the in vitro radioprotection effect of curcumin in HUVEC dosed with gamma radiation. Cells treated …

Selective, Catalytic Decomposition Of Hydrazine, Benjamin A. Kitson, Shirin N. Oliaee

Williams Honors College, Honors Research Projects

The selective, catalytic decomposition of hydrazine has been investigated using a 1 wt% Pt-Ni(OH)₂ catalyst system quantitatively studied by changing the following parameters; reaction solution alkalinity, temperature, hydrazine concentration, catalyst selectivity, catalyst stability, and catalyst durability. Using sodium hydroxide (NaOH), the best alkalinity was found to be 1 M NaOH. The optimal temperature was found to be 50 °C for complete hydrazine conversion. A hydrazine concentration of 0.1 M produced the most effective reaction. The catalyst was found to be completely selective in hydrogen and nitrogen production with no ammonia formation. The catalyst activity decreased by 15% after 8 …

Optimization Of An Agitated Extractor, Evan Zapf

Undergraduate Journal of Mathematical Modeling: One + Two

In this scenario, we use calculus to determine the optimal operating specifications of a chemical extraction process. The results are achieved by first developing an expression that yields the total annual cost of the process. Factoring in electricity, vessel, agitator, and solvent costs, an annual cost expression was fabricated. AGIEX company manufactures a certain amount of a product, A, which has an impurity that it wishes be reduced. By engineering an optimally sized vessel to perform the extraction of impurity, the company will save costs by ensuring no inefficient spending on power or excess solvent occurs. A specific amount of …

Age-Related Hearing Loss: Prevention Of Threshold Declines, Cell Loss And Apoptosis In Spiral Ganglion Neurons, Robert D. Frisina, Bo Ding, Xiaoxia Zhu, Joseph P. Walton

Chemical, Biological and Materials Engineering Faculty Publications

Age-related hearing loss (ARHL) -presbycusis - is the most prevalent neurodegenerative disease and number one communication disorder of our aged population; and affects hundreds of millions of people worldwide. Its prevalence is close to that of cardiovascular disease and arthritis, and can be a precursor to dementia. The auditory perceptual dysfunction is well understood, but knowledge of the biological bases of ARHL is still somewhat lacking. Surprisingly, there are no FDA-approved drugs for treatment. Based on our previous studies of human subjects, where we discovered relations between serum aldosterone levels and the severity of ARHL, we treated middle age mice …

Modeling Of Rheological Properties For Entangled Polymer Systems, Nilanjana Banerjee

Doctoral Dissertations

"The study of entangled polymer rheology both in the field of medicine and polymer processing has their major importance. Mechanical properties of biomolecules are studied in order to better understand cellular behavior. Similarly, industrial processing of polymers needs thorough understanding of rheology so as to improve process techniques. Work in this dissertation has been organized into three major sections. Firstly, numerical/analytical models are reviewed for describing rheological properties and mechanical behaviors of cytoskeleton. The cytoskeleton models are classified into categories according to the length scales of the phenomena of interest. The main principles and characteristics of each model are summarized …

Design, Fabrication, Operation And Aspen Simulation Of Oil Shale Pyrolysis And Biomass Gasification Process Using A Moving Bed Downdraft Reactor, Hassan Golpour

Doctoral Dissertations

"Energy is the major facilitator of the modern life. Every developed and developing economy requires access to advanced sources of energy to support its growth and prosperity. Declining worldwide crude oil reserves and increasing energy needs has focused attention on developing existing unconventional fossil fuels like oil shale and renewable resources such as biomass. Sustainable, renewable and reliable resources of domestically produced biomass comparing to wind and solar energy is a sensible motivation to establish a small-scale power plant using biomass as feed to supply electricity demand and heat for rural development. The work in Paper I focuses on the …

Modeling Explosive Lensing On A Cylindrical Body In Air: A First Step Towards Sealing An Underwater Offshore Oil Spill, Phillip R. Mulligan

Doctoral Dissertations

"In 2010, the British Petroleum (BP) Deepwater Horizon accident leaked oil into the Gulf of Mexico for 87 days. A fast response method that can seal an oil pipe and stop the release of oil is needed in order to prevent future oil leaks from turning into ecological and financial disasters. Explosives can serve this need.

This research examined how a circular implosive discontinuous explosive lens interacts with a cylindrical surface. The following research was designed to study the applicability of the Method this author developed to predict the peak pressure from multiple shockwaves converging on a centrally located cylinder. …

Advancing Microalgae Culturing Via Bubble Dynamics, Mass Transfer, And Dynamic Growth Investigations, Aastha Ojha

Doctoral Dissertations

"The major hindrances to large scale cultivation of microalgae are the problems associated with the design, operation, and scale-up of airlift photobioreactors (PBRs), due to a lack of a comprehensive understanding of the gas-liquid interaction process in real microalgae cultures. Thus, the overall objective of this work is to advance the fundamental understanding of microalgae culturing via gas holdup, bubble dynamics, mass transfer, and dynamic growth investigations.

First, a four-point optical fiber probe technique was employed to study the local gas holdup, and bubble dynamics properties such as bubble passage frequency, chord length and bubble velocity distribution, and interfacial area …

Analysis And Mitigation Of Wellbore Breakout And Fracturing, Reza Rahimi

Doctoral Dissertations

"Mechanical wellbore integrity problems while drilling are mainly due to wellbore shear failure or tensile failure. To ensure wellbore integrity, breakout and fracture geomechanical analysis is conducted to estimate minimum and maximum drilling fluid densities. Currently, there is no agreement as to which rock failure criterion to use for estimating breakout or fracture criteria to use for analyzing drilling induced fractures. However, when wellbore integrity issues arise while drilling, mitigation strategies can be applied to rectify these problems.

This dissertation analyzes criteria for wellbore breakout and fracturing. Also, mitigation strategies for breakout and fracturing while drilling were experimentally investigated. Thirteen …

Wetting Kinetics In Forced Spreading, Amer Mohammad Al-Shareef

Doctoral Dissertations

"Under dynamic conditions, the dynamic contact angle (the angle that the liquid makes with the solid) of a liquid on a solid surface varies dramatically with substrate velocity from its equilibrium value. Experimental data of the dynamic contact angles for polydimethylsiloxane (PDMS or silicone oil) under air on a glass substrate coated with teflon, for water under PDMS, for solutions of the polymer polyethylene oxide (PEO) under air, for solutions of PEO under PDMS, were obtained to simulate and understand the systems of brine or brine containing a polymer displacing viscous crude. A variety of solid substrates were used other …

Modeling And Evaluation Of Moisture Diffusion In Polymer Composite Materials, Zhen Huo

Doctoral Dissertations

"Fiber-reinforced polymer composites have extensive applications due to their high specific strength, improved product performance, low maintenance and design flexibility. However, moisture absorbed by polymer composites during the service life plays a detrimental role in both the integrity and durability of composite structure. It is essential to understand the moisture diffusion behavior and induced damage in polymer matrix composites under varying hygrothermal conditions. In Part I, the moisture diffusion characteristics in hybrid composites using moisture concentration-dependent diffusion method have been investigated. Also, a multi-stage diffusion model was proposed to explain the deviation of moisture diffusion behavior for sandwich composites from …

Phase Transformation And Deformation Behavior Of Niti-Nb Eutectic Joined Niti Wires, Liqiang Wang, Cong Wang, Laichang Zhang, Liangyu Chen, Weijie Lu, Di Zhang

Research outputs 2014 to 2021

NiTi wires were brazed together via eutectic reaction between NiTi and Nb powder deposited at the wire contact region. Phase transformation and deformation behavior of the NiTi-Nb eutectic microstructure were investigated using transmission electron microscopy (TEM) and cyclic loading-unloading tests. Results show that R phase and B19′ martensite transformation are induced by plastic deformation. R phase transformation, which significantly contributes to superelasticity, preferentially occurs at the interfaces between NiTi and eutectic region. Round-shaped Nb-rich phase with rod-like and lamellar-type eutectics are observed in eutectic regions. These phases appear to affect the deformation behavior of the brazed NiTi-Nb region via five …

Floating Constructed Wetland For The Treatment Of Polluted River Water: A Pilot Scale Study On Seasonal Variation And Shock Load, Tanveer Saeed, Biprojit Paul, Rumana Afrin,, Abdullah Al-Muyeed, Guangzhi Sun

Research outputs 2014 to 2021

This paper reports the performance of a pilot scale floating constructed wetland (FCW), employed for the treatment of polluted water collected from Buriganga river in Bangladesh. The FCW system included a tank for accommodating collected water and a floating mat with media, to support the growth of two macrophyte species Phragmites australis and Canna indica. Mean mass removal rates of 0.66, 0.76, 0.08, 0.51, 2.49g/m2d were achieved for ammoniacal nitrogen (NH4-N), total inorganic nitrogen (TIN), phosphorus (P), biochemical oxygen demand (BOD), chemical oxygen demand (COD), respectively by the FCW. Nitrogen removal was via nitrification-denitrification processes, whereas filtration-sedimentation appeared to influence …

A New Insight Into High-Strength Ti62nb12.2fe13.6co6.4al5.8 Alloys With Bimodal Microstructure Fabricated By Semi-Solid Sintering, Lehua Liu, Chao Yang, L.M Kang, Shengguan Qu, Xiaoquiang Li, Weiwen Zhang, Weiping Chen, Yuanyuan Li, Peijie Li, Laichang Zhang

Research outputs 2014 to 2021

It is well known that semi-solid forming could only obtain coarse-grained microstructure in a few alloy systems with a low melting point, such as aluminum and magnesium alloys. This work presents that semi-solid forming could also produce novel bimodal microstructure composed of nanostructured matrix and micro-sized (CoFe)Ti₂ twins in a titanium alloy, Ti₆₂Nb₁₂.2Fe_13.6Co_6.4Al_5.8. The semi-solid sintering induced by eutectic transformation to form a bimodal microstructure in Ti₆₂Nb_12.2Fe_13.6Co_6.4Al_5.8 alloy is a fundamentally different approach from other known methods. The fabricated alloy …

A Novel Approach For The Preparation Of Nanosized Gd2o3 Structure: The Influence Of Surface Force On The Morphology Of Ball Milled Particles, Ly B. T. La, Yee-Kwong Leong, Harry P. Watts, Pek-Ing Watts, Kevin Hayward, Laichang Zhang

Research outputs 2014 to 2021

This work investigates the effect of inter-particle forces arising from adsorbed typical cationic and anionic surfactants on the morphology of ball milled gadolinium oxide (Gd₂O₃). The experimental outcomes are interpreted in terms of stabilization and interaction mechanisms of fine washed Gd₂O₃ particles (size diameter <1 μm) in aqueous medium under the variation of surface forces arising of adsorbed surfactant. After ball milling and washing, the point of zero charge or isoelectric point (IEP) of Gd₂O₃ particles suspension is at pH 11 where its maximum yield stress is observed. Because of hydrophobic interaction, the maximum yield stress increases by 30 times by adsorbed sodium dodecyl sulfate (SDS) and its IEP shifts slightly to a lower pH. By cetyl trimethyl ammonium bromide (CTAB), …

Effect Of Ce And Co Addition To Fe/Al2o3 For Catalytic Methane Decomposition, Ahmed S. Al-Fatesh, Ashraf Amin, Ahmed A. Ibrahim, Wasim Ullah Khan, Moustafa A. Soliman, Raja L. Al-Otaibi, Anis H. Fakeeha

Chemical Engineering

Catalytic methane decomposition is studied in a fixed bed reactor. Two sets of bimetallic catalysts are employed, namely: 30%Fe-X%Ce/Al2O3 and 30%Fe-X%Co/Al2O3, and compared with monometallic 30%Fe/Al2O3 catalyst. The effect of promoting Fe with Ce and Co and reduction temperature are investigated. The results reveal that Ce addition has shown a negative impact on H2 yield while a positive effect on H2 yield and catalyst stability are observed with Co addition. In terms of number of moles of produced hydrogen per active sites, Fe/Al2O3 has shown a higher number of moles of hydrogen compared to bimetallic catalysts. The catalyst reduced at …

High-Temperature, High-Pressure Viscosities And Densities Of Toluene, Aaron J. Rowane

Theses and Dissertations

High-temperature, high-pressure (HTHP) conditions are exemplified in ultra-deep petroleum reservoirs and can be exhibited within diesel engines. Accurate pure component hydrocarbon data is essential in understanding the overall behavior of petroleum and diesel fuel at these conditions. The present study focuses on the HTHP properties of toluene since this hydrocarbon is frequently used to increase the octane rating of gasoline and toluene occurs naturally in crude oil. In this thesis experimental densities and viscosity are presented to 535 K and 300 MPa extending the database of toluene viscosity data to higher temperature than previous studies. The data is correlated to …

Fully Solution Processed Pedot:Pss And Silver Nanowire Semi-Transparent Electrodes For Thin Film Solar Cells, Bjorn Vaagensmith

Electronic Theses and Dissertations

Building integrated photovoltaics (BIPV), such as semitransparent organic solar cells (OSC) for power generating windows, is a promising method for implementing renewable energy under the looming threat of depleting fossil fuels. OSC require a solution processed transparent electrode to be cost effective; but typically employ a nonsolution processed indium tin oxide (ITO) transparent electrode. PEDOT:PSS and silver nanowire transparent electrodes have emerged as a promising alternative to ITO and are solution processed compatible. However, PEDOT:PSS requires a strong acid treatment, which is incompatible with high throughput solution processed fabrication techniques. Silver nanowires suffer from a short lifetime when subject to …

Bio-Inspired Synthesis Of Nanostructured Materials On Substrates For Environmental And Energy Applications, Xinghua Meng Meng

Wayne State University Dissertations

It is still a challenging task to develop simple methods for facile synthesis of functional nanostructures on substrates under mild conditions without using expensive instruments. We have successfully developed a bio-inspired method using simple diaphragm-assisted system to synthesize functional nanostructures on various substrates under mild conditions. We have systematically studied the effects of experimental parameters on the formation of nanostructures under controlled conditions. The fundamental mechanism involved has been systematically studied and revealed. By growing the unique networks of nanostructures on a piece of substrate, a double-rough surface, with structures at both nanoscale and microscale, has been achieved, showing interesting …

Dynamic And Thermal Properties Of Cellulose Nanocrystal/Epoxy Nanocomposites, Jaeyong Shin

Electronic Theses and Dissertations

No abstract provided.

Reverse-Selective Behavior Of The Room Temperature Ionic Liquid Based Membranes, Amir Khakpay

Electronic Theses and Dissertations

This experimental study explore the reverse-selective potential of RTIL based membranes by lowering the solubility of the non-condensing gases like N2 and CH4. It explored reverse-selectivity by measuring the permeance of carbon dioxide, nitrogen, methane, propylene, propane, 1-butene, and butane in supported ionic liquid membranes (SILM). Particular attention was given to the reverse-selective behavior in the propane/methane and propane/nitrogen separations. For this purpose, a series of experiments were conducted in a batch gas permeance system. The permeance of the above-mentioned gases was obtained using polyvinylidene fluoride (PVDF) as the support and [emim][Tf2N], [emim][BF4], [emim][TfO], [emim][DCA], [emim][SCN], and [bmim][NO3] as immobilized …

Development Of A Pressure Swing Adsorption (Psa) Cycle For Co2 Capture From Flue Gas Using A 4-Bed Psa Apparatus, Joshua White

Theses and Dissertations

Pressure swing adsorption is an effective way to capture CO2 from flue gases in energy plants. Pressure swing adsorption utilizes an adsorbent’s selectivity to a specific compound to remove it from a feed stream. Zeolite 13X was used for this research to obtain a high purity and recovery of CO2 at a higher feed flow than previous research. The first part of the work was to use in house FORTRAN based Dynamic Adsorption Process Simulator (DAPS) that uses the finite difference method and the time adaptive Differential- Algebraic Equation (DAE) solver called DASPK to narrow down appropriate experiment criteria for …

X-Ray Protection, Surface Chemistry And Rheology Of Ball-Milled Submicron Gd2o3 Aqueous Suspension, Ly B. T. La, Yee-Kwong Leong, Christopher Leatherday, Pek I. Au, Kevin Hayward, Laichang Zhang

Research outputs 2014 to 2021

X-ray protective garments are typically comprised of lead-based materials, which are toxic to both people and the environment. Developing alternative lightweight radiation shielding materials is a priority for protecting people working with radiation. Gadolinium, with an electron configuration typical of radiation shielding elements, is proposed as a non-toxic replacement for lead. This study provides new insights into the potential for a gadolinium suspension for replacing lead and proposes an inexpensive and effective preparation method. Submicron gadolinium oxide (Gd₂O₃) was generated using a cost effective ball milling method involving addition of NaCl. Then, the dispersed-flocculated behaviour of …

Biodegradable Hybrid Tissue Engineering Scaffolds For Reconstruction Of Large Bone Defects, Danial Barati

Theses and Dissertations

Complex skeletal injuries and large bone fractures are still a significant clinical problem in US. Approximately 1.5 million Americans (veterans, their families, and civilians) every year suffer from bone loss due to traumatic skeletal injuries, infection, and resection of primary tumors that require extensive grafting to bridge the gap. The US bone graft market is over $2.2 billion a year. Due to insufficient mechanical stability, lack of vascularity, and inadequate resorption of the graft, patients with traumatic large skeletal injuries undergo multiple costly operations followed by extensive recovery steps to maintain proper bone alignment and length. Current strategies for repairing …

Bioluminescent Magnetic Nanoparticles As Potential Imaging Agents For Mammalian Spermatozoa, Erick Salvador Vasquez, Jean M. Feugang, Scott T. Willard, Peter L. Ryan, Keisha B. Walters

Chemical and Materials Engineering Faculty Publications

Background: Nanoparticles have emerged as key materials for developing applications in nanomedicine, nanobiotechnology, bioimaging and theranostics. Existing bioimaging technologies include bioluminescent resonance energy transfer-conjugated quantum dots (BRET-QDs). Despite the current use of BRET-QDs for bioimaging, there are strong concerns about QD nanocomposites containing cadmium which exhibits potential cellular toxicity.

Results: In this study, bioluminescent composites comprised of magnetic nanoparticles and firefly luciferase (Photinus pyralis) are examined as potential light-emitting agents for imaging, detection, and tracking mammalian spermatozoa. Characterization was carried out using infrared spectroscopy, TEM and cryo-TEM imaging, and ζ-potential measurements to demonstrate the successful preparation of these nanocomposites. Binding …

Evaluation Of Highly Viscous Polymeric Fluids And Recrosslinked Degraded Gel, Danlu Zhang

Masters Theses

”This work presents the evaluations of two products. One can be used for hydraulic fracturing to achieve viscosity stable under high shear rate, and the other is potential to be applied to enhance oil recovery from mature oilfield.

The first experiment is to synthesize and evaluate a new polymeric fracturing fluid that can resist high shear rate of 511^-1 with favorable viscosity. Zirconium crosslinked fracturing fluids are lack of self-healing ability after shearing, and the difficulties still exist in maintaining viscous with lower polymer content exposed to high shearing conditions, therefore, the research is trying to develop a new …

A Comprehensive Study Of Lost Circulation With Application In The South Rumaila Field, Iraq, Abo Taleb Tuama Al-Hameedi

Masters Theses

“Drilling mud losses and problems associated with lost circulation while drilling account for a major expense in drilling oil and gas wells. By industry estimates, more than 2 billion USD is spent annually to combat and mitigate this problem (Ali et al., 2015).

The South Rumaila field in Iraq is one of the largest oilfields in the world. Wells drilled in this field are highly susceptible to lost circulation problems when drilling through the Dammam, Hartha and Shuaiba formations. Lost circulation events range from seepage losses to complete loss of the borehole and are a critical issue in field development. …

Aspen Simulation Of Oil Shale And Biomass Process, Anand Alembath

Masters Theses

"This thesis focuses on design and analysis of two major chemical processes using computer simulation which performs a steady state computation. The objective is to design processes using Aspen simulation to establish optimum operating conditions by performing various simulation runs which are challenging to execute at lab scale.

Increasing energy needs and decline of global oil prices has shifted our focus on commercially developing unconventional and renewable resources. Commercialization of any process relies on developing a process model that identifies different process parameters by performing a steady state mass and heat balance. Aspen simulation is considered an effective process modeling …

Experimental Evaluations Of Selected Sealants To Remediate Co₂ Leakage, Aaron Jeffrey Blue

Masters Theses

"Carbon Dioxide (CO₂) sequestration into porous and permeable brine-filled aquifers is seen as one of the most feasible solutions for reducing the amount of greenhouse gases released into the atmosphere from coal-fired power plants. To safely store the CO₂, it must be trapped under an impermeable rock acting as a seal. One of the concerns with CO₂ sequestration is the generation of new fractures or reopening of existing fractures caused by CO₂ injection in the sealing formation. This project evaluates the potential of sealing these fractures by injecting sealing materials into them. These sealing …