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Articles 451 - 480 of 2359

Full-Text Articles in Chemical Engineering

Experimental Data On Water Soluble Polymers Thermal And Hydrolytic Stability, Reactivity Ratios Of Monomers And Frr Calculation For Thermally Stable Preformed Particle Gels Therefrom, Buddhabhushan Salunkhe, Thomas P. Schuman, Ali Al Brahim, Baojun Bai Oct 2021

Experimental Data On Water Soluble Polymers Thermal And Hydrolytic Stability, Reactivity Ratios Of Monomers And Frr Calculation For Thermally Stable Preformed Particle Gels Therefrom, Buddhabhushan Salunkhe, Thomas P. Schuman, Ali Al Brahim, Baojun Bai

Chemistry Faculty Research & Creative Works

Experimental data on water soluble polymer thermal and hydrolytic stability in acidic, neutral and basic pH conditions in aqueous solution is presented. Thermal and hydrolytic stability of polymer aqueous solutions were monitored in variable pH medium by aging at 130 °C temperature for different aging time. Polymer viscosity measurements were performed periodically for 3 months. Furthermore, this data can serve as a basis of monomer selection for thermally stable hydrogels for applications like oil recovery, hydrogel coatings for steam sterilized medical devices and other applications. Reactivity ratios were determined for monomers associated to the most stable polymers using 1H …

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Cement Bricks Based On Shredded Automobile Tires, Nour Waheed, Ibrahim M. Ibrahim, M. A. Radwan, M. A. Sadek, Hany A. Elazab Oct 2021

Cement Bricks Based On Shredded Automobile Tires, Nour Waheed, Ibrahim M. Ibrahim, M. A. Radwan, M. A. Sadek, Hany A. Elazab

Chemical and Biochemical Engineering Faculty Research & Creative Works

The essential target of this is to make good, qualified bricks with economic background and to have several uses than ordinary brick that is utilized in construction of homes or any building. From these useful properties of those blocks are acoustic segregation and thermal insulation also with recovery of many wastes that don’t be benefit from them; create from them jobs to be reused and to make brick economically wise and to be applied for example the insulation. From those squandering, are the shredded used tires after being used and it can’t be used anymore. It was cleared that the …

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Effect Of Addition Of Nano Silicon Dioxide To Cement Bricks: Preparation And Characterictics, Rehab Emad, Ibrahim M. Ibrahim, M. A. Radwan, M. A. Sadek, Hany A. Elazab Oct 2021

Effect Of Addition Of Nano Silicon Dioxide To Cement Bricks: Preparation And Characterictics, Rehab Emad, Ibrahim M. Ibrahim, M. A. Radwan, M. A. Sadek, Hany A. Elazab

Chemical and Biochemical Engineering Faculty Research & Creative Works

The aim of the research is to design and produce a durable, and high load, bearing build constructing bricks based on cement, sand, and aggregates with the addition of Nano silica, studying the effect of the added materials to get a background about the impact of the Nano silica on the ability of using such a product. The cement used is 52.5 grade which represent the strength of the cement, sand with particle size 300-600 micrometer, aggregates with diameter lays between 0.5-1 cm better to use smaller size, water, and finally Nano-silica with particle size 17 nm with purity higher …

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Cochlear Inflammaging In Relation To Ion Channels And Mitochondrial Functions, Parveen Bazard, Jennifer Pineros, Robert D. Frisina, Mark A. Bauer, Alejandro A. Acosta, Lauren R. Paganella, Dominika Borakiewicz, Mark Thivierge, Freyda L. Mannering, Xiaoxia Zhu, Bo Ding Oct 2021

Cochlear Inflammaging In Relation To Ion Channels And Mitochondrial Functions, Parveen Bazard, Jennifer Pineros, Robert D. Frisina, Mark A. Bauer, Alejandro A. Acosta, Lauren R. Paganella, Dominika Borakiewicz, Mark Thivierge, Freyda L. Mannering, Xiaoxia Zhu, Bo Ding

Chemical and Biochemical Engineering Faculty Research & Creative Works

The slow accumulation of inflammatory biomarker levels in the body—also known as inflammation—has been linked to a myriad of age-related diseases. Some of these include neurodegenerative conditions such as Parkinson's disease, obesity, type II diabetes, cardiovascular disease, and many others. Though a direct correlation has not been established, research connecting age-related hearing loss (ARHL)—the number one communication disorder and one of the most prevalent neurodegenerative diseases of our aged population—and inflammation has gained interest. Research, thus far, has found that inflammatory markers, such as IL-6 and white blood cells, are associated with ARHL in humans and animals. Moreover, studies investigating …

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Understanding The Plugging Performance Of Hpam-Cr (Iii) Polymer Gel For Co2 Conformance Control, Xindi Sun, Baojun Bai, Ali Khayoon Alhuraishawy, Daoyi Zhu Oct 2021

Understanding The Plugging Performance Of Hpam-Cr (Iii) Polymer Gel For Co2 Conformance Control, Xindi Sun, Baojun Bai, Ali Khayoon Alhuraishawy, Daoyi Zhu

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

With the demand for conformance control in carbon dioxide (CO2) flooding fields, hydrolyzed polyacrylamide-chromium [HPAM-Cr (III)] polymer gel has been applied in fields for CO2 conformance control. However, the field application results are mixed with success and failure. This paper is intended to understand the HPAM-Cr (III) polymer gel plugging performance in CO2 flooding reservoirs through laboratory experiments and numerical analysis. We conducted core flooding tests to understand how the cycles of CO2 and water affect the HPAM-Cr (III) polymer gel plugging efficiency to CO2 and water during a water-alternating-gas (WAG) process. Berea Sandstone …

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Asphaltene Thermodynamic Flocculation During Immiscible Nitrogen Gas Injection, Mukhtar Elturki, Abdulmohsin Imqam Oct 2021

Asphaltene Thermodynamic Flocculation During Immiscible Nitrogen Gas Injection, Mukhtar Elturki, Abdulmohsin Imqam

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Gas-enhanced oil recovery is one of the most advantageous enhanced oil recovery methods. Nitrogen is one of the most investigated gases because of its beneficial properties. However, during its interaction with crude oil, nitrogen can induce asphaltene deposition, which may result in severe formation damage and pore plugging. Few works have investigated the impact of nitrogen on asphaltene instability. This research studied the immiscibility conditions for nitrogen in nanopores and the impact of nitrogen on asphaltene precipitations, which could lead to plugging pores and oil recovery reduction. A slimtube was used to determine the minimum miscibility pressure (MMP) of nitrogen …

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Self-Adhesive Silicone Microstructures For The Treatment Of Tympanic Membrane Perforations, Gabriela Moreira Lana, Katharina Sorg, Gentiana Ioana Wenzel, Dietmar Hecker, René Hensel, Bernhard Schick, Klaus Kruttwig, Eduard Arzt Oct 2021

Self-Adhesive Silicone Microstructures For The Treatment Of Tympanic Membrane Perforations, Gabriela Moreira Lana, Katharina Sorg, Gentiana Ioana Wenzel, Dietmar Hecker, René Hensel, Bernhard Schick, Klaus Kruttwig, Eduard Arzt

Chemical and Biochemical Engineering Faculty Research & Creative Works

Inspired by the gecko foot, polymeric microstructures have demonstrated reliable dry adhesion to both stiff objects and sensitive surfaces such as skin. Microstructured silicone patches are proposed, herein, for the treatment of tympanic membrane perforations with the aim of serving as an alternative for current surgical procedures that require anesthesia and ear canal packing. Sylgard 184 PDMS micropillars of 20 μm in diameter and 60 μm in length are topped by a Soft Skin Adhesive (SSA) MG7-1010 terminal layer, of about 25 μm thickness. The adhesion is evaluated by specially designed tack tests against explanted murine eardrums and, for comparison, …

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A Comprehensive Review Of In-Situ Polymer Gel Simulation For Conformance Control, Baojun Bai, Jianqiao Leng, Mingzhen Wei Sep 2021

A Comprehensive Review Of In-Situ Polymer Gel Simulation For Conformance Control, Baojun Bai, Jianqiao Leng, Mingzhen Wei

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Gel treatment has been widely applied in mature oilfields to improve sweep efficiency and control water production. Correct numerical simulation is of major importance to the optimization design and prediction of a successful gel treatment. However, there exist many problems in current simulation studies in published literature. This paper first presents a comprehensive review on the major factors that have been considered at different gelation stages during gel treatment, the models used in the commercial/in-house simulators, and current numerical simulation studies on both laboratory and field scales. Then we classify the current in-situ gel numerical simulation problems as 1, deficient …

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Impact Of Clay Stabilizer On The Methane Desorption Kinetics And Isotherms Of Longmaxi Shale, China, Zhong Hua Liu, Jia Chun Wang, Baojun Bai, Yan Ling Wang Sep 2021

Impact Of Clay Stabilizer On The Methane Desorption Kinetics And Isotherms Of Longmaxi Shale, China, Zhong Hua Liu, Jia Chun Wang, Baojun Bai, Yan Ling Wang

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Knowing methane desorption characteristics is essential to define the contribution of adsorbed gas to gas well production. To evaluate the synthetic effect of a clay stabilizer solution on methane desorption kinetics and isotherms pertaining to Longmaxi shale, an experimental setup was designed based on the volumetric method. The objective was to conduct experiments on methane adsorption and desorption kinetics and isotherms before and after clay stabilizer treatments. The experimental data were a good fit for both the intraparticle diffusion model and the Freundlich isotherm model. We analyzed the effect of the clay stabilizer on desorption kinetics and isotherms. Results show …

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Optoacoustically Induced Auditory Brainstem Responses In The Mouse Model Enhanced Through An Absorbing Film, Gabriela Lana Sep 2021

Optoacoustically Induced Auditory Brainstem Responses In The Mouse Model Enhanced Through An Absorbing Film, Gabriela Lana

Chemical and Biochemical Engineering Faculty Research & Creative Works

No abstract provided.

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Comparative Evaluation Of Two Glass Polyalkenoate Cements: An In Vivo Pilot Study Using A Sheep Model, Leyla Hasandoost, Daniella Marx, Paul Zalzal, Oleg Safir, Mark Hurtig, Cina Mehrvar, Stephen D. Waldman, Marcello Papini, Mark R. Towler Sep 2021

Comparative Evaluation Of Two Glass Polyalkenoate Cements: An In Vivo Pilot Study Using A Sheep Model, Leyla Hasandoost, Daniella Marx, Paul Zalzal, Oleg Safir, Mark Hurtig, Cina Mehrvar, Stephen D. Waldman, Marcello Papini, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Poly(methyl methacrylate) (PMMA) is used to manage bone loss in revision total knee arthroplasty (rTKA). However, the application of PMMA has been associated with complications such as volumetric shrinkage, necrosis, wear debris, and loosening. Glass polyalkenoate cements (GPCs) have potential bone cementation applications. Unlike PMMA, GPC does not undergo volumetric shrinkage, adheres chemically to bone, and does not undergo an exothermic setting reaction. In this study, two different compositions of GPCs (GPCA and GPCB), based on the patented glass system SiO2-CaO-SrO-P2O5-Ta2O5, were investigated. Working and setting times, pH, ion release, …

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Novel Method Of Manufacture Of Metal Nanoparticles And Metal Single-Atom Materials On Various Substrates And Novel Compositions, Xinhua Liang, Xiaofeng Wang Aug 2021

Novel Method Of Manufacture Of Metal Nanoparticles And Metal Single-Atom Materials On Various Substrates And Novel Compositions, Xinhua Liang, Xiaofeng Wang

Chemical and Biochemical Engineering Faculty Research & Creative Works

The present invention discloses a novel method and novel compositions comprising well-dispersed particulate metal materials, including metal nanoparticles and/or metal single-atom materials, on various substrates, said method comprising the use of atomic layer deposition (ALD) and optimization of the metal precursor dose time and the number of ALD cycles. Illustrative of the metals are Fe, Ni, Co, Ru, Rh, Ir, Os, Pt, Pd, and the like; and illustrative of the various substrates are carbon nanotubes (CNTs) (including multi-walled carbon nanotubes (MWCNTs), SiO2, TiO2, alumina, CeO2, ZnO, ZrO2, activated carbon, CuO, Fe2 …

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In Vitro Osteogenic Performance Of Two Novel Strontium And Zinc-Containing Glass Polyalkenoate Cements, Daniella Marx, Alireza Rahimnejad Yazdi, Marcello Papini, Mark R. Towler Aug 2021

In Vitro Osteogenic Performance Of Two Novel Strontium And Zinc-Containing Glass Polyalkenoate Cements, Daniella Marx, Alireza Rahimnejad Yazdi, Marcello Papini, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Glass polyalkenoate cements (GPCs) are under investigation as potential bone adhesives, as they may provide an alternative to polymethylmethacrylate-based cements. GPCs containing strontium (Sr) and zinc (Zn) in place of aluminum (Al) are of particular interest because these ions are known stimulators of osteoprogenitor differentiation. GPCs have been manufactured from a novel bioactive glass (SiO2:0.48, ZnO:0.36, CaO:0.12, SrO:0.04) in the past, but, while such materials have been assessed for their influence on viability, their influence on osteogenic function has not been investigated until now. For this study, two GPCs were formulated from the same glass precursor evaluated in previous studies. …

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Sealant Injectivity Through Void Space Conduits To Assess Remediation Of Well Cement Failure, Mohammed Alkhamis, Abdulmohsin Imqam Jun 2021

Sealant Injectivity Through Void Space Conduits To Assess Remediation Of Well Cement Failure, Mohammed Alkhamis, Abdulmohsin Imqam

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

The primary cement of oil and gas wells is prone to fail under downhole conditions. Thus, a remedial operation must be conducted to restore the wellbore integrity and provides zonal isolation. Many types of materials are currently used and/or have the potential to be employed in wellbore integrity applications, including, but not limited to, conventional Portland cement, microfine and ultrafine cement, thermoset materials, and thermoplastic materials. In this study, several types of materials were selected for evaluation: (1) conventional Portland cement, which is the most widely used in remedial operations in the petroleum industry, (2) polymer resin, which is one …

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Nano-Enhanced Bioremediation For Oil Spills: A Review, Amber J. Pete, Bhuvnesh Bharti, Michael G. Benton Jun 2021

Nano-Enhanced Bioremediation For Oil Spills: A Review, Amber J. Pete, Bhuvnesh Bharti, Michael G. Benton

Chemical and Biochemical Engineering Faculty Research & Creative Works

Oil seepage and spills have lasting detrimental effects on the environment, especially on nearby marine ecosystems. Despite quick and safe removal of contaminating oil being of utmost importance, remediation methods have remained largely unchanged over the last 20+ years. Removal methods such as skimmers, in situ burning, and sorbents can be difficult to implement in inclement weather. Marine microorganisms consume spilled oil as a primary energy source in a method known as bioremediation. Recently the introduction of nanoparticles to areas contaminated by oil has emerged as a potential method to enhance the efficacy of oil degradation by marine microorganisms. Nanoparticles …

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A Wirelessly Controlled Scalable 3d-Printed Microsystem For Drug Delivery, Farzad Forouzandeh, Nuzhet N. Ahamed, Xiaoxia Zhu, Parveen Bazard, Krittika Goyal, Joseph P. Walton, Robert D. Frisina, David A. Borkholder Jun 2021

A Wirelessly Controlled Scalable 3d-Printed Microsystem For Drug Delivery, Farzad Forouzandeh, Nuzhet N. Ahamed, Xiaoxia Zhu, Parveen Bazard, Krittika Goyal, Joseph P. Walton, Robert D. Frisina, David A. Borkholder

Chemical and Biochemical Engineering Faculty Research & Creative Works

Here we present a 3D-printed, wirelessly controlled microsystem for drug delivery, comprising a refillable micro reservoir and a phase-change peristaltic micropump. The micropump structure was inkjet-printed on the back of a printed circuit board around a catheter microtubing. The enclosure of the microsystem was fabricated using stereolithography 3D printing, with an embedded micro reservoir structure and integrated micropump. In one configuration, the microsystem was optimized for murine inner ear drug delivery with an overall size of 19 x 13 x 3 mm3. Benchtop results confirmed the performance of the device for reliable drug delivery. The suitability of the device for …

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Roles Of Key Ion Channels And Transport Proteins In Age-Related Hearing Loss, Parveen Bazard, Robert D. Frisina, Alejandro A. Acosta, Sneha Dasgupta, Mark A. Bauer, Xiaoxia Zhu, Bo Ding Jun 2021

Roles Of Key Ion Channels And Transport Proteins In Age-Related Hearing Loss, Parveen Bazard, Robert D. Frisina, Alejandro A. Acosta, Sneha Dasgupta, Mark A. Bauer, Xiaoxia Zhu, Bo Ding

Chemical and Biochemical Engineering Faculty Research & Creative Works

The auditory system is a fascinating sensory organ that overall, converts sound signals to electrical signals of the nervous system. Initially, sound energy is converted to mechanical energy via amplification processes in the middle ear, followed by transduction of mechanical movements of the oval window into electrochemical signals in the cochlear hair cells, and finally, neural signals travel to the central auditory system, via the auditory division of the 8th cranial nerve. The majority of people above 60 years have some form of age-related hearing loss, also known as presbycusis. However, the biological mechanisms of presbycusis are complex and not …

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A Gallium-Doped Cement For The Treatment Of Bone Cancers. The Effect Of Zno ↔ Ga2o3substitution Of An Ionomeric Glass Series On The Rheological, Mechanical, Ph And Ion-Eluting Properties Of Their Corresponding Glass Polyalkenoate Cements, Sunjeev Phull, Alireza Rahimnejad Yazdi, Mark R. Towler Jun 2021

A Gallium-Doped Cement For The Treatment Of Bone Cancers. The Effect Of Zno ↔ Ga2o3substitution Of An Ionomeric Glass Series On The Rheological, Mechanical, Ph And Ion-Eluting Properties Of Their Corresponding Glass Polyalkenoate Cements, Sunjeev Phull, Alireza Rahimnejad Yazdi, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

The primary treatment for patients suffering from bone cancers is resection of the tumor followed by reconstruction of the damaged bone. Despite the administration of post-operative chemotherapy, tumor recurrence continues to present itself as a severe complication leading to re-operation. Attempts to incorporate chemotherapeutic drugs into bone cements elicits local toxic effects on healthy bone, which could compromise implant fixation. Alternatively, the local administration of gallium (Ga) may prove to be more effective. This report considers the development of a Ga ionomeric glass series (0.48SiO2-0.355ZnO-0.06CaO-0.08SrO-0.02P2O5-0.005Ta2O5, with 0.01-0.05 mol% substitution for …

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Dynamics In Drops As Confined Systems Containing Nanoparticles: Reformation Of Nanoparticles And Evaporation Of Water, Vijitha Mohan, Xianjie Qiu, Partho Neogi May 2021

Dynamics In Drops As Confined Systems Containing Nanoparticles: Reformation Of Nanoparticles And Evaporation Of Water, Vijitha Mohan, Xianjie Qiu, Partho Neogi

Chemical and Biochemical Engineering Faculty Research & Creative Works

Brine is used to displace crude oil in a reservoir and its performance improves when brine contains nanoparticles. It is the presence of nanoparticles in confinements, such as at dynamic contact lines and in thin films, which is of importance. The investigators here have determined a fast way to obtain confined systems by evaporating a small drop of water containing nanoparticles. Water droplets containing nanoparticles of alumina or silica were evaporated on surfaces of polyethylene terephthalate sheets, which are partially wet by water, and glass which is fully wet. After the liquid in the drops evaporated, the residues were examined …

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Settling Of Spherical Particles In High Viscosity Friction Reducer Fracture Fluids, Ghith Biheri, Abdulmohsin Imqam May 2021

Settling Of Spherical Particles In High Viscosity Friction Reducer Fracture Fluids, Ghith Biheri, Abdulmohsin Imqam

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Investigating the key factors that impact fluid rheology and proppant static settling velocity in high viscosity friction reducers (HVFRs) is a critical aspect for successful proppant transport in hydraulic fracture treatment. In this study, the rheological properties of HVFRs were tested at various temperature ranges (i.e., 25, 50, 75, and 100◦C) and different HVFR concentrations (i.e., 1, 2, 4, and 8 gpt). Three sizes of spherical particle diameters (i.e., 2, 4, and 6 mm) were selected to measure the static settling velocity. The fracture fluid was tested in two fracture models: an unconfined glass model and a confined rectangular model …

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Heavy Oil And Vapex Process: A Brief Review, Vijitha Mohan, Parthasakha Neogi, Baojun Bai May 2021

Heavy Oil And Vapex Process: A Brief Review, Vijitha Mohan, Parthasakha Neogi, Baojun Bai

Chemical and Biochemical Engineering Faculty Research & Creative Works

Heavy oil recovery requires either heat or solvent assistance to reduce its high viscosity first and then the less viscous oil can be recovered. Processes that use vapor assisted petroleum extraction (VAPEX) utilize vaporized solvent. Solvent vapors are introduced through a top injection well to induce viscosity reduction and the less viscous oil is collected at the bottom production well. It is noteworthy, that the solvent itself when recovered, can be seen as an integral part of oil. Exact molecular weight and chemistry of heavy oil is uncertain making analysis of thermodynamic properties difficult, however this is overcome by making …

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In Vivo Analysis Of A Proprietary Glass-Based Adhesive For Sternal Fixation And Stabilization Using Rabbit And Sheep Models, Cina Mehrvar, Emily Deignan, Mark Hurtig, Gideon Cohen, Paul Zalzal, Oleg Safir, Adel Alhalawani, Marcello Papini, Mark R. Towler May 2021

In Vivo Analysis Of A Proprietary Glass-Based Adhesive For Sternal Fixation And Stabilization Using Rabbit And Sheep Models, Cina Mehrvar, Emily Deignan, Mark Hurtig, Gideon Cohen, Paul Zalzal, Oleg Safir, Adel Alhalawani, Marcello Papini, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Wire cerclage remains the standard method of care for sternal fixation, following median sternotomy, despite being beset with complications. An emerging treatment option has been to augment the wires with an adhesive. A patented ionomeric glass (mole fraction: SiO2:0.48, ZnO:0.36, CaO:0.12, SrO:0.04) has been used to formulate GPC+, a glass polyalkenoate cement (GPC), by mixing it with poly(acrylic) acid (PAA) and de-ionized water. In a human cadaver study, this material, when applied with wire cerclage, was able to significantly reduce sternal instability. However, the material has yet to be tested in pertinent animal models. Here, after a series …

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Recovery Of Degraded Lithium Ion Cathode Particles, James Kirtley Apr 2021

Recovery Of Degraded Lithium Ion Cathode Particles, James Kirtley

Undergraduate Research Conference at Missouri S&T

This project focuses on recovering the cathode materials of lithium ion batteries through atomic layer deposition (ALD) thin film coating. In industry, when a cathode material for a lithium ion battery are stored, it reacts with CO2 and moisture in the air creating Li2CO3 and LiOH on the particle surface. The harmful substances on the surfaces have a negative impact on battery performance and battery life. In this study, we found that when Li2Ni0.8Mn0.1Co0.1 (Ni-Rich NMC) is exposed to a high amount of moisture it degrades and the performance is reduced. For example, the discharge capacity of Degraded Ni-Rich NMC …

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Effects Of Sleep Deprivation On Learning In Fruit Flies, Natalie Gardner Apr 2021

Effects Of Sleep Deprivation On Learning In Fruit Flies, Natalie Gardner

Undergraduate Research Conference at Missouri S&T

The fruit fly Drosophila Melanogaster is an optimal research specimen when observing the effects of sleep deprivation on spatial learning. A fly's sleep can be tracked using locomotion while it is undisturbed and while it undergoes sleep deprivation. To measure a fly's visuospatial awareness, a region at a comfortable 24 degrees Celsius, among the rest of the arena yielding an uncomfortable temperature ranging from 36-37 degrees Celsius, is fit with a specific visual cue that the fly is able to identify. This region, along with it's visual cue, is rotated around the arena every 3 minutes, and the amount of …

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Laboratory-Scale Research Of Non-Catalyzed Supercritical Alcohol Process For Continuous Biodiesel Production, Aso A. Hassan, Joseph D. Smith Apr 2021

Laboratory-Scale Research Of Non-Catalyzed Supercritical Alcohol Process For Continuous Biodiesel Production, Aso A. Hassan, Joseph D. Smith

Chemical and Biochemical Engineering Faculty Research & Creative Works

This work investigates the non-catalyzed supercritical methanol (SCM) process for continuous biodiesel production. The lab-scale setup was designed and used for biodiesel production in the temperature range of 520–650 K and 83–380 bar with an oil-to-methanol molar ratio ranging from 1:5 to 1:45. The experiments were performed in the coiled plug flow tubular reactor. The volumetric flow rate of the methanol/oil ranged from 0.1-10 mL/min. This work examines a new reactor technology involving preheating and pre-mixing of the methanol/oil mixture to reduce setup cost and increase biodiesel yield under the same reaction conditions. Work performed showed that FAME’s yield increased …

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Gagrank: Software For Glycosaminoglycan Sequence Ranking Using A Bipartite Graph Model, John D. Hogan, Jiandong Wu, Joshua A. Klein, Cheng Lin, Luis Carvalho, Joseph Zaia Apr 2021

Gagrank: Software For Glycosaminoglycan Sequence Ranking Using A Bipartite Graph Model, John D. Hogan, Jiandong Wu, Joshua A. Klein, Cheng Lin, Luis Carvalho, Joseph Zaia

Chemical and Biochemical Engineering Faculty Research & Creative Works

The Sulfated Glycosaminoglycans (GAGs) Are Long, Linear Polysaccharide Chains that Are Typically Found as the Glycan Portion of Proteoglycans. These GAGs Are Characterized by Repeating Disaccharide Units with Variable Sulfation and Acetylation Patterns Along the Chain. GAG Length and Modification Patterns Have Profound Impacts on Growth Factor Signaling Mechanisms Central to Numerous Physiological Processes. Electron Activated Dissociation Tandem Mass Spectrometry is a Very Effective Technique for Assigning the Structures of GAG Saccharides; However, Manual Interpretation of the Resulting Complex Tandem Mass Spectra is a Difficult and Time-Consuming Process that Drives the Development of Computational Methods for Accurate and Efficient Sequencing. …

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Ion Pairing And Dielectric Decrement In Glycosaminoglycan Brushes, James D. Sterling, Wenjuan Jiang, Wesley M. Botello-Smith, Yun L. Luo Mar 2021

Ion Pairing And Dielectric Decrement In Glycosaminoglycan Brushes, James D. Sterling, Wenjuan Jiang, Wesley M. Botello-Smith, Yun L. Luo

Business and Information Technology Faculty Research & Creative Works

Cell−surface polysaccharides are essential to many aspects of physiology, serving as a highly conserved evolutionary feature of life and as an important part of the innate immune system in mammals. Here, as simplified biophysical models of these sugar coatings, we present results of molecular dynamics simulations of hyaluronic acid and heparin brushes that show important effects of ion pairing, water dielectric decrease, and coion exclusion. As in prior studies of macromolecular crowding under physiologically relevant salt concentrations, our results show equilibria with electroneutrality attained through screening and pairing of brush anionic charges by monovalent cations at the atomistic detail. Most …

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Acute Dose-Dependent Neuroprotective Effects Of Poly(Pro-17Β-Estradiol) In A Mouse Model Of Spinal Contusion Injury, Manoj K. Gottipati, Samuel A.T. Ellman, Devan L. Puhl, Zhen Guan, Phillip G. Popovich, Edmund F. Palermo, Ryan J. Gilbert Mar 2021

Acute Dose-Dependent Neuroprotective Effects Of Poly(Pro-17Β-Estradiol) In A Mouse Model Of Spinal Contusion Injury, Manoj K. Gottipati, Samuel A.T. Ellman, Devan L. Puhl, Zhen Guan, Phillip G. Popovich, Edmund F. Palermo, Ryan J. Gilbert

Chemical and Biochemical Engineering Faculty Research & Creative Works

17β-Estradiol (E2) confers neuroprotection in preclinical models of spinal cord injury when administered systemically. The goal of this study was to apply E2 locally to the injured spinal cord for a sustained duration using poly(pro-E2) film biomaterials. Following contusive spinal cord injury in adult male mice, poly(pro-E2) films were implanted subdurally and neuroprotection was assessed using immunohistochemistry 7 days after injury and implantation. In these studies, poly(pro-E2) films modestly improved neuroprotection without affecting the inflammatory response when compared to the injured controls. To increase the E2 dose released, bolus-releasing poly(pro-E2) films were fabricated by incorporating unbound E2 into the poly(pro-E2) …

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Translational Implications Of The Interactions Between Hormones And Age-Related Hearing Loss, R. D. Frisina, Parveen Bazard, M. Bauer, J. Pineros, X. Zhu, B. Ding Mar 2021

Translational Implications Of The Interactions Between Hormones And Age-Related Hearing Loss, R. D. Frisina, Parveen Bazard, M. Bauer, J. Pineros, X. Zhu, B. Ding

Chemical and Biochemical Engineering Faculty Research & Creative Works

Provocative research has revealed both positive and negative effects of hormones on hearing as we age; with in some cases, mis-regulation of hormonal levels in instances of medical comorbidities linked to aging, lying at the heart of the problem. Animal model studies have discovered that hormonal fluctuations can sharpen hearing for improved communication and processing of mating calls during reproductive seasons. Sex hormones sometimes have positive effects on auditory processing, as is often the case with estrogen, whereas combinations of estrogen and progesterone, and testosterone, can have negative effects on hearing abilities, particularly in aging subjects. Too much or too …

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Conventional Immunomarkers Stain A Fraction Of Astrocytes In Vitro: A Comparison Of Rat Cortical And Spinal Cord Astrocytes In Naïve And Stimulated Cultures, Bailey Balouch, Jessica L. Funnell, Alexis M. Ziemba, Devan L. Puhl, Kathy Lin, Manoj K. Gottipati, Ryan J. Gilbert Mar 2021

Conventional Immunomarkers Stain A Fraction Of Astrocytes In Vitro: A Comparison Of Rat Cortical And Spinal Cord Astrocytes In Naïve And Stimulated Cultures, Bailey Balouch, Jessica L. Funnell, Alexis M. Ziemba, Devan L. Puhl, Kathy Lin, Manoj K. Gottipati, Ryan J. Gilbert

Chemical and Biochemical Engineering Faculty Research & Creative Works

Astrocytes are responsible for a wide variety of essential functions throughout the central nervous system. The protein markers glial fibrillary acidic protein (GFAP), glutamate aspartate transporter (GLAST), glutamate transporter-1 (GLT-1), glutamine synthetase (GS), 10-formyltetrahydrofolate dehydrogenase (ALDH1L1), and the transcription factor SOX9 are routinely used to label astrocytes in primary rodent cultures. However, GLAST, GLT-1, GS, and SOX9 are also produced by microglia and oligodendrocytes and GFAP, GLAST, GLT-1, and GS production levels are affected by astrocyte phenotypic changes associated with reactive astrogliosis. No group has performed a comprehensive immunocytochemical evaluation to quantify the percentage of cells labeled by these markers …

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