Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Biochemical and Biomolecular Engineering (13)
- Physical Sciences and Mathematics (9)
- Biomedical Engineering and Bioengineering (7)
- Catalysis and Reaction Engineering (6)
- Chemistry (6)
-
- Mechanical Engineering (6)
- Materials Science and Engineering (5)
- Other Chemical Engineering (5)
- Analytical Chemistry (4)
- Life Sciences (4)
- Medicine and Health Sciences (3)
- Metallurgy (3)
- Microbiology (3)
- Thermodynamics (3)
- Transport Phenomena (3)
- Biochemistry, Biophysics, and Structural Biology (2)
- Biological and Chemical Physics (2)
- Chemicals and Drugs (2)
- Civil and Environmental Engineering (2)
- Complex Fluids (2)
- Computer Sciences (2)
- Education (2)
- Electrical and Computer Engineering (2)
- Energy Systems (2)
- Engineering Education (2)
- Molecular, Cellular, and Tissue Engineering (2)
- Other Chemistry (2)
- Physics (2)
- Keyword
-
- Coal (59)
- Pyrolysis (48)
- Biomass (27)
- Combustion (25)
- Ultrasound (22)
-
- Drug delivery (19)
- Molecular dynamics (19)
- Model predictive control (18)
- Soot (18)
- Cell-free protein synthesis (17)
- Deposition (17)
- Simulation (15)
- Doxorubicin (14)
- Pressure (14)
- Model (13)
- Molecular simulations (13)
- Molten salt (13)
- Char (12)
- Dynamic optimization (12)
- Electrochemistry (11)
- Monte Carlo methods (11)
- Ash Deposition (10)
- Gas Turbine (10)
- Optimization (10)
- Polymers (10)
- Tar (10)
- Kinetics (9)
- Modeling (9)
- Phase transitions (9)
- Swelling (9)
- Publication Year
- Publication
- Publication Type
- File Type
Articles 601 - 630 of 759
Full-Text Articles in Chemical Engineering
Development And Evaluation Of A Sub-Grid Combustion Model For A Landscape Scale 3-D Wildland Fire Simulator, Michael M. Clark
Development And Evaluation Of A Sub-Grid Combustion Model For A Landscape Scale 3-D Wildland Fire Simulator, Michael M. Clark
Theses and Dissertations
A mixture-fraction-based thermodynamic equilibrium approach for modeling gas-phase combustion was adapted and used in FIRETEC, a wildfire computational fluid dynamics model. The motivation behind this work was the desire to incorporate the features of complex chemistry calculations from the thermodynamic equilibrium model into FIRETEC without significantly increasing the computational burden of the program. In order to implement the mixture-fraction-based thermodynamic equilibrium approach, a sub-grid pocket model was developed to simulate the local mixture fraction of sub-grid flame sheets. Numerical simulations of wildfires were performed using FIRETEC with the new sub-grid, mixture-fraction-based pocket model to model gas-phase combustion. The thermodynamic equilibrium …
Modeling Of Electronic And Ionic Transport Resistances Within Lithium-Ion Battery Cathodes, David E. Stephenson
Modeling Of Electronic And Ionic Transport Resistances Within Lithium-Ion Battery Cathodes, David E. Stephenson
Theses and Dissertations
In this work, a mathematical model is reported and validated, which describes the performance of porous electrodes under low and high rates of discharge. This porous battery model can be used to provide researchers a better physical understanding relative to prior models of how cell morphology and materials affect performance due to improved accounting of how effective resistance change with morphology and materials. The increased understanding of cell resistances will enable improved design of cells for high-power applications, such as hybrid and plug-in-hybrid electric vehicles. It was found electronic and liquid-phase ionic transport resistances are strongly coupled to particle conductivity, …
Nano-Polymeric Carrier Influences Ultrasonic Drug Delivery To Tumors, Odgerel Badamjav, Ghaleb A. Husseini, Peter Jones, William G. Pitt, Beverly L. Roeder
Nano-Polymeric Carrier Influences Ultrasonic Drug Delivery To Tumors, Odgerel Badamjav, Ghaleb A. Husseini, Peter Jones, William G. Pitt, Beverly L. Roeder
Faculty Publications
Our overall research goal is to alleviate the severe side effects of chemotherapy while enhancing the effectiveness of the treatment by localizing the delivery of anti-cancer drugs to the cancer tissue only. To this end we are synthesizing ultrasonically-activated delivery systems that can control drug delivery in space and time. Ultrasound (US) is non-invasive (no surgery required) and can be focused on the specific tissue to be treated. Our past research has developed a nano-sized polymeric drug carrier that sequesters the therapeutic drug, such as Doxorubicin (Dox), within the carrier and releases the drug upon insonation by ultrasound. This drug-containing …
Mpsa Effects On Copper Electrodeposition Investigated By Molecular Dynamics Simulations, John N. Harb, Richard L. Rowley, Dean R. Wheeler, Clint G. Guymon
Mpsa Effects On Copper Electrodeposition Investigated By Molecular Dynamics Simulations, John N. Harb, Richard L. Rowley, Dean R. Wheeler, Clint G. Guymon
Faculty Publications
In superconformal filling of copper-chip interconnects, organic additives are used to fill high-aspect-ratio trenches or vias from the bottom up. In this study we report on the development of intermolecular potentials and use molecular dynamics simulation.
Characteristics Of Black Liquor Sprays From Gas-Assisted Atomizers In Hightemperature Environments, Andrew J. Mackrory, Dale Tree, Larry L. Baxter
Characteristics Of Black Liquor Sprays From Gas-Assisted Atomizers In Hightemperature Environments, Andrew J. Mackrory, Dale Tree, Larry L. Baxter
Faculty Publications
Black liquor droplets in an entrained-flow gasifier that are too large or too small can cause problems in the chemical recovery process. It is therefore important in gasifier design to understand the nature of the atomized-gas spray. We used high-speed imaging to study black liquor sprays in cold and hot environments. Significant conclusions are that: 1. the droplet size distribution width is linked to the mean droplet size as for other sprays in the literature, necessitating a gasifier design that is tolerant of the distribution width associated with the target droplet size; 2. the shape of black liquor droplets is …
Evolution Of Surface Deposits On A High-Pressure Turbine Blade—Part I: Physical Characteristics, James Edward Wammack, Jared M. Crosby, Daniel Fletcher, Jeffrey P. Bons, Thomas H. Fletcher
Evolution Of Surface Deposits On A High-Pressure Turbine Blade—Part I: Physical Characteristics, James Edward Wammack, Jared M. Crosby, Daniel Fletcher, Jeffrey P. Bons, Thomas H. Fletcher
Faculty Publications
Turbine blade coupons with three different surface treatments were exposed to deposition conditions in an accelerated deposition facility. The facility simulates the flow conditions at the inlet to a first stage high-pressure turbine (T=1150 C, M=0.31). The combustor exit flow is seeded with dust particulate that would typically be ingested by a large utility power plant. The three coupon surface treatments included: (1) bare polished metal; (2) polished thermal barrier coating with bondcoat; and (3) unpolished oxidation resistant bondcoat. Each coupon was subjected to four successive 2 h deposition tests. The particulate loading was scaled to simulate 0.02 parts per …
Effects Of Temperature And Particle Size On Deposition In Land Based Turbines, Jared M. Crosby, Scott Lewis, Jeffrey P. Bons, Weiguo Ai, Thomas H. Fletcher
Effects Of Temperature And Particle Size On Deposition In Land Based Turbines, Jared M. Crosby, Scott Lewis, Jeffrey P. Bons, Weiguo Ai, Thomas H. Fletcher
Faculty Publications
Four series of tests were performed in an accelerated deposition test facility to study the independent effects of particle size, gas temperature, and metal temperature on ash deposits from two candidate power turbine synfuels (coal and petcoke). The facility matches the gas temperature and velocity of modern first stage high pressure turbine vanes while accelerating the deposition process. Particle size was found to have a significant effect on capture efficiency with larger particles causing significant thermal barrier coating (TBC) spallation during a 4 h accelerated test. In the second series of tests, particle deposition rate was found to decrease with …
Evolution Of Surface Deposits On A High-Pressure Turbine Blade—Part Ii: Convective Heat Transfer, Jeffrey P. Bons, James Edward Wammack, Jared M. Crosby, Daniel Fletcher, Thomas H. Fletcher
Evolution Of Surface Deposits On A High-Pressure Turbine Blade—Part Ii: Convective Heat Transfer, Jeffrey P. Bons, James Edward Wammack, Jared M. Crosby, Daniel Fletcher, Thomas H. Fletcher
Faculty Publications
A thermal barrier coating (TBC)-coated turbine blade coupon was exposed to successive deposition in an accelerated deposition facility simulating flow conditions at the inlet to a first stage high pressure turbine (T=1150 C, M=0.31). The combustor exit flow was seeded with dust particulate that would typically be ingested by a large utility power plant. The turbine coupon was subjected to four successive 2 h deposition tests. The particulate loading was scaled to simulate 0.02 parts per million weight (ppmw) of particulate over 3 months of continuous gas turbine operation for each 2 h laboratory simulation (for a cumulative 1 year …
Transient Molecular Dynamics Simulations Of Viscosity For Simple Fluids, Richard L. Rowley, Jason C. Thomas
Transient Molecular Dynamics Simulations Of Viscosity For Simple Fluids, Richard L. Rowley, Jason C. Thomas
Faculty Publications
A transient molecular dynamics (TMD) method has been developed for simulation of fluid viscosity. In this method a sinusoidal velocity profile is instantaneously overlaid onto equilibrated molecular velocities, and the subsequent decay of that velocity profile is observed. The viscosity is obtained by matching in a least-squares sense the analytical solution of the corresponding momentum transport boundary-value problem to the simulated decay of the initial velocity profile. The method was benchmarked by comparing results obtained from the TMD method for a Lennard-Jones fluid with those previously obtained using equilibrium molecular dynamics (EMD) simulations. Two different constitutive models were used in …
Two-Dimensional Modeling Of Ap/Htpb Utilizing A Vorticity Formulation And One-Dimensional Modeling Of Ap And Adn, Matthew L. Gross
Two-Dimensional Modeling Of Ap/Htpb Utilizing A Vorticity Formulation And One-Dimensional Modeling Of Ap And Adn, Matthew L. Gross
Theses and Dissertations
This document details original numerical studies performed by the author pertaining to the propellant oxidizer, ammonium perchlorate (AP). Detailed kinetic mechanisms have been utilized to model the combustion of the monopropellants AP and ADN, and a two-dimensional diffusion flame model has been developed to examine the flame structure above an AP/HTPB composite propellant. This work was part of an ongoing effort to develop theoretically based, a priori combustion models. The improved numerical model for AP combustion utilizes a “universal” gas-phase kinetic mechanism previously applied to combustion models of HMX, RDX, GAP, GAP/RDX, GAP/HMX, NG, BTTN, TMETN, GAP/BTTN, and GAP/RDX/BTTN. The …
The Effect Of Flame Structure On Soot Formation And Transport In Turbulent Nonpremixed Flames Using Direct Numerical Simulation, David O. Lignell, Jacqueline H. Chen, Philip J. Smith, Tianfeng Lu, Chung K. Law
The Effect Of Flame Structure On Soot Formation And Transport In Turbulent Nonpremixed Flames Using Direct Numerical Simulation, David O. Lignell, Jacqueline H. Chen, Philip J. Smith, Tianfeng Lu, Chung K. Law
Faculty Publications
Direct numerical simulations of a two-dimensional, nonpremixed, sooting ethylene flame are performed to examine the effects of soot–flame interactions and transport in an unsteady configuration. A 15-step, 19-species (with 10 quasi-steady species) chemical mechanism was used for gas chemistry, with a two-moment, four-step, semiempirical soot model. Flame curvature is shown to result in flames that move, relative to the fluid, either toward or away from rich soot formation regions, resulting in soot being essentially convected into or away from the flame. This relative motion of flame and soot results in a wide spread of soot in the mixture fraction coordinate. …
Comprehensive Study Of Biomass Fly Ash In Concrete: Strength, Microscopy, Kinetics And Durability, Shuangzhen Wang, Larry Baxter
Comprehensive Study Of Biomass Fly Ash In Concrete: Strength, Microscopy, Kinetics And Durability, Shuangzhen Wang, Larry Baxter
Faculty Publications
ASTM (American Standard Testing and Materials) C 618 prohibits use of biomass fly ash in concrete. This document systematically investigates the strength, microscopic study and durability (mitigation of Alkali Silica Reaction (ASR) expansion) of biomass fly ash concrete (cement partially replaced by fly ash) and kinetics of the mixture of biomass fly ash and calcium hydroxide. The biomass fly ash in the investigation comes from cofired (herbaceous with coal) fly ash, which includes different kinds of coal and biomass. All the results show that biomass fly ash with cofiring concentration within the interest to commercial coal–biomass cofiring operations at power …
Potential Energy Surfaces For Small Alcohol Dimers. Ii. Propanol, Isopropanol, T-Butanol, And Sec-Butanol, Richard L. Rowley, Christopher M. Tracy, Tapani A. Pakkanen
Potential Energy Surfaces For Small Alcohol Dimers. Ii. Propanol, Isopropanol, T-Butanol, And Sec-Butanol, Richard L. Rowley, Christopher M. Tracy, Tapani A. Pakkanen
Faculty Publications
Potential energy landscapes for homogeneous dimers of propanol, isopropanol, tert-butanol, and sec-butanol were obtained using 735 counterpoise-corrected energies at the MP2/6-311+G(2df,2pd) level. The landscapes were sampled at 15 dimer separation distances for different relative monomer geometries, or routes, given in terms of the yaw, pitch, and roll of one monomer relative to the other and the spherical angles between the two monomer centers (taken as the C atom attached to the O). The resultant individual energy surfaces and their complex topographies were also regressed using a site-site pair potential model using a modified Morse potential that provides a mathematically simple …
Ultrasonically-Assisted Drug Delivery In Rats Reduces Tumor Growth, William G. Pitt, Beverly L. Roeder, G. Bruce Schaalje, Bryant J. Staples
Ultrasonically-Assisted Drug Delivery In Rats Reduces Tumor Growth, William G. Pitt, Beverly L. Roeder, G. Bruce Schaalje, Bryant J. Staples
Faculty Publications
Previously we have shown that nanosized drug carriers called Plurogels™ sequestered Doxorubicin (Dox) and partially released this drug with application of ultrasound (US) (Fig. 1)1. The application to chemotherapy was successfully demonstrated in a rat tumor model2. However previous studies did not examine the distribution of Dox in the insonated and control tissue. This recent work investigated the effect of two US frequencies and examined the Dox distribution in the insonated and control tumors to determine if US was depositing more Dox at the insonated site.
Bubble Dynamics Of Ultrasonic Drug Release From Polymeric Micelles, Mario A. Diaz, William G. Pitt
Bubble Dynamics Of Ultrasonic Drug Release From Polymeric Micelles, Mario A. Diaz, William G. Pitt
Faculty Publications
We have reported the ability of Pluronic P-105 micelles to sequester anthracycline drugs and release their contents upon application of 70 kHz ultrasound (US)1 (Figure 1). Optimal targeting to tumors depends on focus and control of US insonation, which is better achieved at higher frequencies. While no evidence of in vitro drug release was found at 500 kHz, drug release at 70 kHz correlates with the intensity of the subharmonic signal in the acoustic spectrum generated by the insonated bubbles2(Figure 2). Having established that bubble oscillations (cavitation) are directly related to drug release at 70 kHz, we now investigate the …
A New Method For Treating Wells In Reservoir Simulation, Gregory M. Gessel
A New Method For Treating Wells In Reservoir Simulation, Gregory M. Gessel
Theses and Dissertations
A new method for formulating finite difference equations for reservoir simulation has been developed. It can be applied throughout the entire simulated reservoir or to local segments. When applied to cells containing vertical, fully penetrating, straight-line wells in a homogeneous reservoir, the resulting equations are equivalent to Peaceman's classical well equations used in most reservoir simulators today. However, when the new finite difference equations are applied to both the well-containing cells, and their neighbors, the accuracy of the simulation improves substantially. The method produces still better accuracy results when applied throughout the reservoir. Unlike the Peaceman correction, the new method …
Pharmacokinetics Of Ultrasonically-Released, Micelle-Encapsulated Doxorubicin In The Rat Model And Its Effect On Tumor Growth, Bryant J. Staples
Pharmacokinetics Of Ultrasonically-Released, Micelle-Encapsulated Doxorubicin In The Rat Model And Its Effect On Tumor Growth, Bryant J. Staples
Theses and Dissertations
Chemotherapy is one of the most successful cancer treatments used today. Unfortunately, the amount of chemotherapy a patient can receive is limited by the associated negative side effects, such as cardiotoxicity, immune system suppression, and nephrotoxicity. Encapsulation of these drugs, Doxorubicin (DOX) in particular, in stabilized Pluronic micelles (Plurogel TM) shows success in limiting these harmful side effects. In previous studies, low-frequency ultrasound (US) has been shown, in vitro, to locally release DOX from these micelles. In this study, a novel drug delivery system involving the encapsulation of DOX in Plurogel and the release of the drug at the tumor …
Biomass And Coal Fly Ash In Concrete: Strength, Durability, Microstructure, Quantitative Kinetics Of Pozzolanic Reaction And Alkali Silica Reaction Investigations., Shuangzhen Wang
Theses and Dissertations
Biomass represents an important sustainable energy resource, with biomass-coal cofiring representing among the most effective and cost efficient CO2 reduction strategies. Fly ash generated during coal combustion represents a technically advantageous, inexpensive, and environmentally beneficial admixture in concrete production, partially replacing cement. However, strict interpretation of American Society of Testing and Materials (ASTM) and American Concrete Institute (ACI) standards prohibits use of fly ashes from any source other than coal in concrete production; therefore, fly ash from biomass coal cofiring is excluded from use in concrete. This dissertation discusses biomass impacts on concrete properties through experiments conducted on several combinations …
Modeling Three Reacting Flow Systems With Modern Computational Fluid Dynamics, Ralph J. Price
Modeling Three Reacting Flow Systems With Modern Computational Fluid Dynamics, Ralph J. Price
Theses and Dissertations
Computational fluid dynamics (CFD) modeling and analysis were used in three projects: solar CO2 conversion modeling, improved coal combustion modeling using STAR-CD, and premixed combustion modeling. Each project is described below. The solar CO2 conversion modeling project involved CFD simulations of a prototype solar CO2 converter that uses sunlight to dissociate CO2 into CO and O2. Modeling was used to predict the performance of this prototype converter using three CFD software packages, and involved predicting the flow, heat transfer, and chemical kinetics. Accuracy was determined by comparison of model predictions and experimental data. Parametric modeling studies were performed in order …
Production Of Hydrogen And Sulfur From Hydrogen Sulfide In A Nonthermal-Plasma Pulsed Corona Discharge Reactor, Morris D. Argyle, Gui-Bing Zhao, Sanil John, Ji-Jun Zhang, Jerry C. Hamann, Suresh S. Muknahallipatna, Stanislaw Legowski, John F. Ackerman
Production Of Hydrogen And Sulfur From Hydrogen Sulfide In A Nonthermal-Plasma Pulsed Corona Discharge Reactor, Morris D. Argyle, Gui-Bing Zhao, Sanil John, Ji-Jun Zhang, Jerry C. Hamann, Suresh S. Muknahallipatna, Stanislaw Legowski, John F. Ackerman
Faculty Publications
Hydrogen Sulfide (H2S) dissociation into hydrogen and sulfur has been studied in a pulsed corona discharge reactor (PCDR). Due to the high dielectric strength of pure H2S (~2.9 times higher than air), a non-thermal plasma could not be sustained in pure H2S at discharge voltages up to 30kV with our reactor geometry. Therefore, H2S was diluted with another gas with lower dielectric strength to reduce the breakdown voltage. Breakdown voltages of H2S in four balance gases (Ar, He, N2 and H2) have been measured at different H2S concentrations and pressures. Breakdown voltages are proportional to the partial pressure of H2S …
Continuous Co-Separation By Liquid Absorption In Aqueous Cuprous Chloride (Cucl) And Magnesium Chloride (Mgcl2) Solution, Paul J. Foster
Continuous Co-Separation By Liquid Absorption In Aqueous Cuprous Chloride (Cucl) And Magnesium Chloride (Mgcl2) Solution, Paul J. Foster
Theses and Dissertations
The purpose of the research was to design, build, test, and recommend a process to economically separate CO from a gas mixture of CO, CO2, and O2. The general method considered in this research to accomplish the separation was liquid absorption in a packed column. Several experiments were performed to identify the best process solution to use in a prototype. The experiments, based on the COSORB process, consisted of CuCl mixed with a complexing agent (metal tri-chloride) and a solvent (metal tetra-chloride, toluene, ethanol, etc.). The best method consisted of an aqueous solution of CuCl and MgCl2, which has previously …
Structure And Nitrogen Chemistry In Coal, Biomass, And Cofiring Low-Nox Flames, Bradley David Damstedt
Structure And Nitrogen Chemistry In Coal, Biomass, And Cofiring Low-Nox Flames, Bradley David Damstedt
Theses and Dissertations
Addressing global climate change will require increasing sustainable energy usage. Cofiring biomass fuels with coal for electrical power generation is an efficient, cost effective method of CO2 mitigation. This work is an experimental investigation of the flame structure and nitrogen chemistry differences occurring between coal, biomass and cofiring flames. A pilot-scale facility was fired with a dual-feed low-NOx burner capable of independently conveying 2 separate fuels unblended to the burner. Spatially detailed gas species measurements were made for 8 flames, including a coal, straw, finely ground straw, wood, and 4 straw/coal cofiring flames. Particle samples were also obtained from 5 …
The Role Of Ultrasound Cavitation In Liposome Size Reduction, William G. Pitt, Eric S. Richardson, Dixon J. Woodbury
The Role Of Ultrasound Cavitation In Liposome Size Reduction, William G. Pitt, Eric S. Richardson, Dixon J. Woodbury
Faculty Publications
Liposome size is a vital parameter of many quantitative biophysical studies. Sonication, or exposure to ultrasound, is used widely to manufacture artificial liposomes, yet little is known about the mechanism by which liposomes are affected by ultrasound. Cavitation, or the oscillation of small gas bubbles in a pressure-varying field, has been shown to be responsible for many biophysical effects of ultrasound on cells. Collapse cavitation is manifested in the acoustic spectrum by an f/2 subharmonic and an increase in broadband noise. In this study, we attempted to correlate the presence of cavitation with a decrease in liposome size. Lipid suspensions …
A Coarse Grain Model For Dna, Thomas A. Knotts, Nitin Rathore, David C. Schwartz, Juan J. De Pablo
A Coarse Grain Model For Dna, Thomas A. Knotts, Nitin Rathore, David C. Schwartz, Juan J. De Pablo
Faculty Publications
Understanding the behavior of DNA at the molecular level is of considerable fundamental and engineering importance. While adequate representations of DNA exist at the atomic and continuum level, there is a relative lack of models capable of describing the behavior of DNA at mesoscopic length scales. We present a mesoscale model of DNA that reduces the complexity of a nucleotide to three interactions sites, one each for the phosphate, sugar, and base, thereby rendering the investigation of DNA up to a few microns in length computationally tractable. The charges on these sites are considered explicitly. The model is parametrized using …
Optical Emission Study Of Nonthermal Plasma Confirms Reaction Mechanisms Involving Neutral Rather Than Charged Species, Gui-Bing Zhao, Morris D. Argyle, Maciej Radosz
Optical Emission Study Of Nonthermal Plasma Confirms Reaction Mechanisms Involving Neutral Rather Than Charged Species, Gui-Bing Zhao, Morris D. Argyle, Maciej Radosz
Faculty Publications
Charge transfer reactions are commonly used to explain NOx conversion in nonthermal plasma. An analysis of optical emission spectra induced by pulsed corona discharge in NOx-containing argon suggests that, in fact, the contribution of charge transfer reactions to NOx conversion in nonthermal plasma is negligible. During electrical discharge in such gas mixtures, NO (B), an electronic excited state of NO formed due to the dissociative recombination reactions of NOx+ and N2O+ and the optical emission of NO (B) could be a proof that cations are responsible for NOx conversion. However, …
Modeling And Sensitivity Analysis Of Acoustic Release Of Doxorubicin From Unstabilized Pluronic P105 Using An Artificial Neural Network Model, Ghaleb A. Husseini, Nabil M. Abdel-Jabbar, Farouq S. Mjalli, William G. Pitt
Modeling And Sensitivity Analysis Of Acoustic Release Of Doxorubicin From Unstabilized Pluronic P105 Using An Artificial Neural Network Model, Ghaleb A. Husseini, Nabil M. Abdel-Jabbar, Farouq S. Mjalli, William G. Pitt
Faculty Publications
This paper models steady state acoustic release of Doxorubicin (Dox) from Pluronic P105micelles using Artificial Neural Networks (ANN). Previously collected release data werecompiled and used to train, validate, and test an ANN model. Sensitivity analysis was thenperformed on the following operating conditions: ultrasonic frequency, power density, Plu-ronic P105 concentration, and temperature. The model showed that drug release was mostefficient at lower frequencies. The analysis also demonstrated that release increases as thepower density increases. Sensitivity plots of ultrasound intensity revealed a drug releasethreshold of 0.015 W/cm2 and 0.38 W/cm2 at 20 and 70 kHz, respectively. The presence ofa power density threshold …
An Improved Model For Calculating Heats Of Dilution And Equilibrium Constants For High Temperature Aqueous Electrolyte Solutions, Xiaoyun Lin
Theses and Dissertations
At high temperatures, the properties of aqueous electrolyte systems differ markedly from those at 25°C. For mixed-electrolyte dilute solutions at high temperatures, the degree of ion-association is sufficiently large that the association equilibrium must be incorporated in any model describing the solutions. These association reactions usually do not occur to a measurable extent at room temperature. Oscarson and co-workers have designed a correlation model based on the excess Gibbs energy which can correlate log K and ∆H values as well as the heats of dilution for aqueous electrolyte systems as a function of temperature (T) and ionic strength (I) from …
High-Frequency Ultrasound Drug Delivery And Cavitation, Mario Alfonso Diaz
High-Frequency Ultrasound Drug Delivery And Cavitation, Mario Alfonso Diaz
Theses and Dissertations
The viability of a drug delivery system which encapsulates chemotherapeutic drugs (Doxorubicin) in the hydrophobic core of polymeric micelles and triggers release by ultrasound application was investigated at an applied frequency of 500 kHz. The investigation also included elucidating the mechanism of drug release at 70 kHz, a frequency which had previously been shown to induce drug release. A fluorescence detection chamber was used to measure in vitro drug release from both Pluronic and stabilized micelles and a hydrophone was used to monitor bubble activity during the experiments. A threshold for release between 0.35 and 0.40 in mechanical index was …
Heat And Mass Transport In Heat Pipe Wick Structures, Brian D. Iverson, Tyler W. Davis, Suresh V. Garimella, Mark T. North, Sukhvinder S. Kang
Heat And Mass Transport In Heat Pipe Wick Structures, Brian D. Iverson, Tyler W. Davis, Suresh V. Garimella, Mark T. North, Sukhvinder S. Kang
Faculty Publications
A novel experimental approach is developed for characterizing the performance of heat pipe wick structures. This approach simulates the actual operation of wick structures in a heat pipe. Open, partially submerged, sintered copper wicks of varying pore size are studied under the partially saturated conditions found in normal heat pipe operation. A vertical wick orientation, where the capillary lift is in opposition to gravity, is selected to test the wicks under the most demanding conditions. Mass transport measurements of the working fluid, in addition to the temperature field, are obtained for the porous wicks under the action of a discrete …
Model Compound Study Of The Pathways For Aromatic Hydrocarbon Formation In Soot, Randall E. Winans, Nancy A. Tomczyk, Jerry E. Hunt, Mark S. Solum, Ronald J. Pugmire, Thomas H. Fletcher
Model Compound Study Of The Pathways For Aromatic Hydrocarbon Formation In Soot, Randall E. Winans, Nancy A. Tomczyk, Jerry E. Hunt, Mark S. Solum, Ronald J. Pugmire, Thomas H. Fletcher
Faculty Publications
As a follow-up of previous work on the flame pyrolysis of biphenyl and pyrene, a more detailed analysis of the pyrolytic products has been done using additional NMR data obtained on the whole soot sample correlated with detailed high-resolution and GC mass spectrometry data on the solvent-extracted portion of the same samples. These latter data complement the earlier NMR data with details of the pre-sooting structures, referred to as “young soot”, in pyrolyzed biphenyl samples collected at 1365, 1410, and 1470 K and pyrene at 1410 and 1470 K. The data reveal the roles played by free-radical-assisted polymerization reactions as …