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Biomedical Engineering and Bioengineering Commons™
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Articles 91 - 104 of 104
Full-Text Articles in Biomedical Engineering and Bioengineering
Application Of Composite Hydrogels To Control Physical Properties In Tissue Engineering And Regenerative Medicine, Cassidy Sheffield, Kaylee Meyers, Emil Johnson, Rupak Rajachar
Application Of Composite Hydrogels To Control Physical Properties In Tissue Engineering And Regenerative Medicine, Cassidy Sheffield, Kaylee Meyers, Emil Johnson, Rupak Rajachar
Michigan Tech Publications, Part 1
The development of biomaterials for the restoration of the normal tissue structure–function relationship in pathological conditions as well as acute and chronic injury is an area of intense investigation. More recently, the use of tailored or composite hydrogels for tissue engineering and regenerative medicine has sought to bridge the gap between natural tissues and applied biomaterials more clearly. By applying traditional concepts in engineering composites, these hydrogels represent hierarchical structured materials that translate more closely the key guiding principles required for improved recovery of tissue architecture and functional behavior, including physical, mass transport, and biological properties. For tissue-engineering scaffolds in …
Metabolism-Driven High-Throughput Cancer Identification With Glut5-Specific Molecular Probes, Srinivas Kannan, Vagarshak Begoyan, Joseph Fedie, Shuai Xia, Łukasz J. Weseliński, Marina Tanasova, Smitha Rao
Metabolism-Driven High-Throughput Cancer Identification With Glut5-Specific Molecular Probes, Srinivas Kannan, Vagarshak Begoyan, Joseph Fedie, Shuai Xia, Łukasz J. Weseliński, Marina Tanasova, Smitha Rao
Michigan Tech Publications, Part 1
Point-of-care applications rely on biomedical sensors to enable rapid detection with high sensitivity and selectivity. Despite advances in sensor development, there are challenges in cancer diagnostics. Detection of biomarkers, cell receptors, circulating tumor cells, gene identification, and fluorescent tagging are time-consuming due to the sample preparation and response time involved. Here, we present a novel approach to target the enhanced metabolism in breast cancers for rapid detection using fluorescent imaging. Fluorescent analogs of fructose target the fructose-specific transporter GLUT5 in breast cancers and have limited to no response from normal cells. These analogs demonstrate a marked difference in adenocarcinoma and …
The Suitability Of Zn–1.3% Fe Alloy As A Biodegradable Implant Material, Alon Kafri, Shira Ovadia, Jeremy Goldman, Jaroslaw W. Drelich, Eli Aghion
The Suitability Of Zn–1.3% Fe Alloy As A Biodegradable Implant Material, Alon Kafri, Shira Ovadia, Jeremy Goldman, Jaroslaw W. Drelich, Eli Aghion
Michigan Tech Publications, Part 1
Efforts to develop metallic zinc for biodegradable implants have significantly advanced following an earlier focus on magnesium (Mg) and iron (Fe). Mg and Fe base alloys experience an accelerated corrosion rate and harmful corrosion products, respectively. The corrosion rate of pure Zn, however, may need to be modified from its reported ~20 µm/year penetration rate, depending upon the intended application. The present study aimed at evaluating the possibility of using Fe as a relatively cathodic biocompatible alloying element in zinc that can tune the implant degradation rate via microgalvanic effects. The selected Zn–1.3wt %Fe alloy composition produced by gravity casting …
The Prospects Of Zinc As A Structural Material For Biodegradable Implants—A Review Paper, Galit Katarivas Levy, Jeremy Goldman, Eli Aghion
The Prospects Of Zinc As A Structural Material For Biodegradable Implants—A Review Paper, Galit Katarivas Levy, Jeremy Goldman, Eli Aghion
Michigan Tech Publications, Part 1
In the last decade, iron and magnesium, both pure and alloyed, have been extensively studied as potential biodegradable metals for medical applications. However, broad experience with these material systems has uncovered critical limitations in terms of their suitability for clinical applications. Recently, zinc and zinc-based alloys have been proposed as new additions to the list of degradable metals and as promising alternatives to magnesium and iron. The main byproduct of zinc metal corrosion, Zn2+, is highly regulated within physiological systems and plays a critical role in numerous fundamental cellular processes. Zn2+ released from an implant may suppress …
Effects Of Short Term Hypoxia-Preconditioning On Glial Phenotype Induction Of Human Mesenchymal Stem Cells, Zichen Qian, Qi Xing, Corey Fase, Kyle Jansen, Feng Zhao
Effects Of Short Term Hypoxia-Preconditioning On Glial Phenotype Induction Of Human Mesenchymal Stem Cells, Zichen Qian, Qi Xing, Corey Fase, Kyle Jansen, Feng Zhao
Michigan Tech Publications, Part 1
Development of successful clinical treatments for peripheral nerve injury is limited due to the complications behind neural physiology. Human mesenchymal stem cells (hMSCs) have the ability to directly promote tissue repair and protect cells at the injury site. Studies have shown that hMSCs can be transplanted to improve nerve regeneration. Hypoxic culture condition has been proven to maintain the stemness of hMSCs for later differentiation. In this study, we investigated the effects of low oxygen (O2) (2% and 5% O2) pre-treatment and initial seeding density (500, 1000, and 2000 cells/cm2) on glial protein expression …
Direct Measurement Of Actual Levels Of Nitric Oxide (No) In Cell Culture Conditions Using Soluble No Donors, Weilue He, Megan C. Frost
Direct Measurement Of Actual Levels Of Nitric Oxide (No) In Cell Culture Conditions Using Soluble No Donors, Weilue He, Megan C. Frost
Michigan Tech Publications, Part 1
Applying soluble nitric oxide (NO) donors is the most widely used method to expose cells of interest to exogenous NO. Because of the complex equilibria that exist between components in culture media, the donor compound and NO itself, it is very challenging to predict the dose and duration of NO cells actually experience. To determine the actual level of NO experienced by cells exposed to soluble NO donors, we developed the CellNO Trap, a device that allows continuous, real-time monitoring of the level of NO adherent cells produce and/or experience in culture without the need to alter cell culturing procedures. …
Cellno Trap: Novel Device For Quantitative, Real-Time, Direct Measurement Of Nitric Oxide From Cultured Raw 267.4 Macrophages, Weilue He, Megan C. Frost
Cellno Trap: Novel Device For Quantitative, Real-Time, Direct Measurement Of Nitric Oxide From Cultured Raw 267.4 Macrophages, Weilue He, Megan C. Frost
Michigan Tech Publications, Part 1
Nitric oxide (NO), is arguably one of the most important small signaling molecules in biological systems. It regulates various biological responses in both physiological and pathological conditions, often time producing seemingly contradictory results. The details of the effects of NO are highly dependent on the level of NO that cells experience and the temporal aspect of when and how long cells are exposed to NO. Herein, we present a novel measurement system (CellNO trap) that allows real-time NO measurement via chemiluminescence detection from general adhesive cultured cells using standard cell culture media and reagents that does not perturb the cells …
The Application Of Biomedical Engineering Techniques To The Diagnosis And Management Of Tropical Diseases: A Review, Fatimah Ibrahim, Tzer Hwai Gilbert Thio, Tarig Faisal, Michael Neuman
The Application Of Biomedical Engineering Techniques To The Diagnosis And Management Of Tropical Diseases: A Review, Fatimah Ibrahim, Tzer Hwai Gilbert Thio, Tarig Faisal, Michael Neuman
Michigan Tech Publications, Part 1
This paper reviews a number of biomedical engineering approaches to help aid in the detection and treatment of tropical diseases such as dengue, malaria, cholera, schistosomiasis, lymphatic filariasis, ebola, leprosy, leishmaniasis, and American trypanosomiasis (Chagas). Many different forms of non-invasive approaches such as ultrasound, echocardiography and electrocardiography, bioelectrical impedance, optical detection, simplified and rapid serological tests such as lab-on-chip and micro-/nano-fluidic platforms and medical support systems such as artificial intelligence clinical support systems are discussed. The paper also reviewed the novel clinical diagnosis and management systems using artificial intelligence and bioelectrical impedance techniques for dengue clinical applications.
Application Of Sub-Micrometer Vibrations To Mitigate Bacterial Adhesion, Will R. Paces, Hal Holmes, Eli Vlaisavljevich, Katherine L. Snyder, Ee Lim Tan, Rupak Rajachar, Keat Ghee Ong
Application Of Sub-Micrometer Vibrations To Mitigate Bacterial Adhesion, Will R. Paces, Hal Holmes, Eli Vlaisavljevich, Katherine L. Snyder, Ee Lim Tan, Rupak Rajachar, Keat Ghee Ong
Michigan Tech Publications, Part 1
As a prominent concern regarding implantable devices, eliminating the threat of opportunistic bacterial infection represents a significant benefit to both patient health and device function. Current treatment options focus on chemical approaches to negate bacterial adhesion, however, these methods are in some ways limited. The scope of this study was to assess the efficacy of a novel means of modulating bacterial adhesion through the application of vibrations using magnetoelastic materials. Magnetoelastic materials possess unique magnetostrictive property that can convert a magnetic field stimulus into a mechanical deformation. In vitro experiments demonstrated that vibrational loads generated by the magnetoelastic materials significantly …
Novel Device For Continuous Spatial Control And Temporal Delivery Of Nitric Oxide For In Vitro Cell Culture, Genevieve E. Romanowicz, Weilue He, Matthew Nielsen, Megan C. Frost
Novel Device For Continuous Spatial Control And Temporal Delivery Of Nitric Oxide For In Vitro Cell Culture, Genevieve E. Romanowicz, Weilue He, Matthew Nielsen, Megan C. Frost
Michigan Tech Publications, Part 1
Nitric oxide (NO) is an ubiquitous signaling molecule of intense interest in many physiological processes. Nitric oxide is a highly reactive free radical gas that is difficult to deliver with precise control over the level and timing that cells actually experience. We describe and characterize a device that allows tunable fluxes and patterns of NO to be generated across the surface upon which cells are cultured. The system is based on a quartz microscope slide that allows for controlled light levels to be applied to a previously described photosensitive NO-releasing polydimethylsiloxane (PDMS). Cells are cultured in separate wells that are …
Fabrication Of Biocompatible, Vibrational Magnetoelastic Materials For Controlling Cellular Adhesion, Hal Holmes, Ee Lim Tan, Keat Ghee Ong, Rupak Rajachar
Fabrication Of Biocompatible, Vibrational Magnetoelastic Materials For Controlling Cellular Adhesion, Hal Holmes, Ee Lim Tan, Keat Ghee Ong, Rupak Rajachar
Michigan Tech Publications, Part 1
This paper describes the functionalization of magnetoelastic (ME) materials with Parylene-C coating to improve the surface reactivity to cellular response. Previous study has demonstrated that vibrating ME materials were capable of modulating cellular adhesion when activated by an externally applied AC magnetic field. However, since ME materials are not inherently biocompatible, surface modifications are needed for their implementation in biological settings. Here, the long-term stability of the ME material in an aqueous and biological environment is achieved by chemical-vapor deposition of a conformal Parylene-C layer, and further functionalized by methods of oxygen plasma etching and protein adsorption. In vitro cytotoxicity …
Design, Fabrication, And Implementation Of A Wireless, Passive Implantable Pressure Sensor Based On Magnetic Higher-Order Harmonic Fields, Ee Lim Tan, Andrew Derouin, Brandon D. Pereles, Keat Ghee Ong
Design, Fabrication, And Implementation Of A Wireless, Passive Implantable Pressure Sensor Based On Magnetic Higher-Order Harmonic Fields, Ee Lim Tan, Andrew Derouin, Brandon D. Pereles, Keat Ghee Ong
Michigan Tech Publications, Part 1
A passive and wireless sensor was developed for monitoring pressure in vivo. Structurally, the pressure sensor, referred to as the magneto-harmonic pressure sensor, is an airtight chamber sealed with an elastic pressure membrane. A strip of magnetically-soft material is attached to the bottom of the chamber and a permanent magnet strip is embedded inside the membrane. Under the excitation of an externally applied AC magnetic field, the magnetically-soft strip produces a higher-order magnetic signature that can be remotely detected with an external receiving coil. As ambient pressure varies, the pressure membrane deflects, altering the separation distance between the magnetically-soft strip …
Implantable Biosensors For Real-Time Strain And Pressure Monitoring, Ee Lim Tan, Brandon D. Pereles, Brock Horton, Ranyuan Shao, Mohammed Zourob, Keat Ghee Ong
Implantable Biosensors For Real-Time Strain And Pressure Monitoring, Ee Lim Tan, Brandon D. Pereles, Brock Horton, Ranyuan Shao, Mohammed Zourob, Keat Ghee Ong
Michigan Tech Publications, Part 1
Implantable biosensors were developed for real-time monitoring of pressure and strain in the human body. The sensors, which are wireless and passive, consisted of a soft magnetic material and a permanent magnet. When exposed to a low frequency AC magnetic field, the soft magnetic material generated secondary magnetic fields that also included the higher-order harmonic modes. Parameters of interest were determined by measuring the changes in the pattern of these higher-order harmonic fields, which was achieved by changing the intensity of a DC magnetic field generated by a permanent magnet. The DC magnetic field, or the biasing field, was altered …
A Wireless, Passive Sensor For Quantifying Packaged Food Quality, Ee Lim Tan, Wen Ni Ng, Ranyuan Shao, Brandon D. Pereles, Keat Ghee Ong
A Wireless, Passive Sensor For Quantifying Packaged Food Quality, Ee Lim Tan, Wen Ni Ng, Ranyuan Shao, Brandon D. Pereles, Keat Ghee Ong
Michigan Tech Publications, Part 1
This paper describes the fabrication of a wireless, passive sensor based on aninductive-capacitive resonant circuit, and its application for in situ monitoring of thequality of dry, packaged food such as cereals, and fried and baked snacks. The sensor ismade of a planar inductor and capacitor printed on a paper substrate. To monitor foodquality, the sensor is embedded inside the food package by adhering it to the package’sinner wall; its response is remotely detected through a coil connected to a sensor reader. Asfood quality degrades due to increasing humidity inside the package, the paper substrateabsorbs water vapor, changing the capacitor’s capacitance …