Open Access. Powered by Scholars. Published by Universities.®
Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
-
- EEG (4)
- Electroencephalography (3)
- FNIRS (3)
- Functional connectivity (3)
- Calcitriol (2)
-
- Cognitive function (2)
- Microchannel (2)
- Near-Infrared Spectroscopy (2)
- Obstructive sleep apnea (2)
- Photobiomodulation (2)
- Prostate cancer (2)
- Sleep apnea (2)
- 3D Printing (1)
- Actin (1)
- Adipocyte (1)
- African Americans (1)
- Alpha band (1)
- Antibodies (1)
- Apnea duration (1)
- Bacterial cellulose (1)
- Biomechanics (1)
- Biophotonics (1)
- Blood flow (1)
- Blood pressure variation (1)
- Brain network (1)
- Breath-hold MRI scan (1)
- Broadband near-infrared Spectroscopy (1)
- CCO (1)
- CVD (1)
- Cancer detection (1)
- Publication Year
- File Type
Articles 151 - 180 of 194
Full-Text Articles in Biomedical Engineering and Bioengineering
Large Array Emg Monitoring Of Lumbar Region Muscle Action In Discogenic Low Back Pain, Jazzmyne Ann Richardson Buckels
Large Array Emg Monitoring Of Lumbar Region Muscle Action In Discogenic Low Back Pain, Jazzmyne Ann Richardson Buckels
Bioengineering Theses - Archive
This project explored the use of large array surface electromyography (LASE) as a technique for assessing the patterns of muscular activity under standardized loading conditions in patients with lumbar disc related pain and healthy subjects. Specifically, the project evaluated quantitative parameters of visually observed patterns of muscle action proposed to clinically discriminate between groups. If such correlates exist, then, this work may lead to technology assessment for sensitivity and specificity as a diagnostic procedure. Solutions to the issues for determining the effects of low back pain (LBP) on force and moment generation in the spine as well as its effect …
A Functional Analysis Of The Mechanically And Metabolically Sensitive Components Of The Skeletal Muscle Exercise Pressor Reflex In Hypertension, Anna Katherine Leal
A Functional Analysis Of The Mechanically And Metabolically Sensitive Components Of The Skeletal Muscle Exercise Pressor Reflex In Hypertension, Anna Katherine Leal
Bioengineering Theses - Archive
Background - In hypertension, physical activity creates a risk for adverse cardiac events by causing exaggerated increases in mean arterial pressure (MAP) and heart rate (HR). One physiological mechanism responsible for this cardiovascular hyperactivity is the exercise pressor reflex (EPR). The EPR is a neural pathway originating in skeletal muscle that contributes to cardiovascular regulation during exercise. The EPR is composed of two afferent arms: one is comprised of mostly mechanically sensitive, group III afferent fibers that respond to muscle stretch and pressure, and the other is predominantly metabolically sensitive, group IV afferent fibers that respond to the chemical milieu …
Spatial Resolution And Biliary Tissue Classification Properties Of A Near Infrared Light Imaging Probe, Praveen Kumar Gulaka
Spatial Resolution And Biliary Tissue Classification Properties Of A Near Infrared Light Imaging Probe, Praveen Kumar Gulaka
Bioengineering Theses - Archive
Approximately 500,000 Gallbladder Surgeries or Laparoscopic Cholecystectomies are performed annually to remove the Gallbladder. This surgery becomes necessary due to formation of gall stones. As biliary tract tissues are embedded in fat, differentiating them from neighboring tissues and blood vessels is critical in helping surgeons during laparoscopic cholecystectomy to avoid post-surgical complications. Optical spectroscopy (in both visible and near infrared regions) is investigated as a possible technique to identify biliary tract tissues and blood vessels. Such reflectance measurements provide information of effective attenuation, which is an index of optical properties of the tissue.Specifically, optical reflectance measurements were made on biliary …
Characterization Of A Hyperspectral Imager: A Diagnostic Tool For Monitoring Retinal Diseases, Nirad Zinzuwadia
Characterization Of A Hyperspectral Imager: A Diagnostic Tool For Monitoring Retinal Diseases, Nirad Zinzuwadia
Bioengineering Theses - Archive
We developed a novel hyperspectral slit lamp ophthalmoscope for visualizing vascular changes for clinical monitoring of retinal diseases, for example, diabetic retinopathy. The device consists of a visible charge couple device, CCD, and liquid crystal tunable filter, LCTF, coupled to the standard clinical slit lamp ophthalmoscope. The LCTF is used as a spectral light source illuminating the retina with different wavelengths of light that are recorded by the CCD and stored as a series of wavelength dependent images of the retina. Chemometric analysis produces a gray scale encoded image for the percentage of oxyhemoglobin at each pixel within the field …
Detection Of Positive Cancer Margins Intra-Operatively During Nephrectomy And Prostatectomy Using Optical Reflectance Spectroscopy, Disha Laxman Peswani
Detection Of Positive Cancer Margins Intra-Operatively During Nephrectomy And Prostatectomy Using Optical Reflectance Spectroscopy, Disha Laxman Peswani
Bioengineering Theses - Archive
In recent years optical spectroscopies have become the basis for popular research activity directed towards the development of novel, noninvasive technologies for tissue diagnostics. The motivation for my research was to eliminate the need for surgical removal of tissue samples for biopsy and histology. With the help of an optical probe placed on or near the surface of the tissue, Near Infrared (NIR) spectroscopy can provide diagnostic signatures, non-invasively and in real time. While the ultimate goal vi is the elimination of the need to remove tissue samples, this technology can also be used to provide additional guidance during laparoscopic …
Foreign Body Reactions To Neural Implants In The Brain, Parisa Lotfi
Foreign Body Reactions To Neural Implants In The Brain, Parisa Lotfi
Bioengineering Theses - Archive
Neural implants have been used and studied for many decades. They are applied to record neural signals or to locally deliver drugs. Unfortunately, foreign body reaction and accompanied glial scar formation often lead to implant failure. The lack of knowledge about the molecular mechanism governing foreign body reactions in the brain significantly hinders the development of brain implantable devices with improved safety and biocompatibility. To study the immune responses to brain implants, a novel animal model has been developed and used for the following investigation. Our studies have established cell recruitment time courses of astrocytes, microglial cells, lymphocytes, monocytes and …
Functionalized Nanoparticles For The Selective Killing Of Cancer Cells, Paul Todd Thevenot
Functionalized Nanoparticles For The Selective Killing Of Cancer Cells, Paul Todd Thevenot
Bioengineering Theses - Archive
The use of nanoparticles for cancer imaging and drug delivery has produced some success in improving the efficacy and safety of cancer chemotherapy. It is generally believed that the efficiency of nanoparticle-based cancer therapy would be greatly improved if such particles could be designed to directly interact with and eradicate tumor. Many recent studies have revealed that surface functionality plays an important role in particle:cell interactions. Using titanium dioxide (TiO2) nanoparticles (21 nm diameter) as test subjects, nanoparticles with different functional groups, hydroxyl (-OH), amine (-NH2), and carboxyl (-COOH) were produced and used in this investigation. An in vitro cell …
Cytotoxic Evaluation And Factorial Analysis Of 3d Photopolymerizable Thermoresponsive Composite Nanoparticle Hydrogels For Controlled Drug Delivery In Restenosis And Wound Healing, Abhimanyu Rajaram Sabnis
Cytotoxic Evaluation And Factorial Analysis Of 3d Photopolymerizable Thermoresponsive Composite Nanoparticle Hydrogels For Controlled Drug Delivery In Restenosis And Wound Healing, Abhimanyu Rajaram Sabnis
Bioengineering Theses - Archive
To develop a smart drug delivery system for restenosis and wound healing applications, we investigated photopolymerizable composite nanoparticle hydrogels which can release the drug in a temperature-responsive manner. Our novel system consisting of thermoresponsive poly(N-isopropylacrylamide-co-acrylamide) (PNIPA-AAm) nanoparticles and poly(ethylene glycol) diacrylate (PEGDA) as photo cross-linker can be formed in situ in presence of ultraviolet (UV) light and Irgacure 2959 photoinitiator (PI). The main aims of this project were to investigate the system cytotoxicity and optimize drug release characteristics by performing biocompatibility and factorial analysis studies, respectively. We evaluated the cell survival of human vascular smooth muscle cells and NIH/3T3 fibroblasts …
Investigation Of Brain Activities Using Two State-Of-The-Art Diffuse Optical Imagers, Suresh Prajapati
Investigation Of Brain Activities Using Two State-Of-The-Art Diffuse Optical Imagers, Suresh Prajapati
Bioengineering Theses - Archive
Near-Infrared Spectroscopy (NIRS) and diffuse optical imaging (DOI) are increasingly used to detect hemodynamic changes in the cerebral cortex induced by brain activity. The new commercially available DOI systems CW5 and DYNOT have large number of sources and detectors; by arranging them in specific patterns, one can cover most of the adult head. This study is a preliminary step in understanding CW5 and DYNOT and exploring their capabilities for various purposes. My work is divided in to three major parts. The first goal of this study was to study changes in hemodynamic response of brain during Breath holding, using both …
Gas Permeation Through Nanoporous Polycarbonate Track- Etched Membranes: Pulsed Plasma Polymerization Of Thin Coatings To Modulate Gas Permeability, Christopher Lewis Chapman
Gas Permeation Through Nanoporous Polycarbonate Track- Etched Membranes: Pulsed Plasma Polymerization Of Thin Coatings To Modulate Gas Permeability, Christopher Lewis Chapman
Bioengineering Theses - Archive
Polycarbonate track-etched membranes (PCTE) of 50nm and 100nm pore size, precoated with Poly Vinyl Pyrrolidone (PVP), were surface treated with either Vinyl Acetic acid (VAA) or Perfluorohexane (C6F14) using a low duty cycle pulsed plasma polymerization technique. The effects of this surface treatment on gas permeation properties of the PCTE were addressed. Plasma coating thickness was controllably varied and resulted in gradual reduction of O2 and CO2 permeability as thickness increased from 10nm to 100nm. Plasma coating material, permeant gas, membrane pore size, and crosslink density were also varied in order to gain insight into the permeation properties of the …
Investigation Of Information Processing And Cognitive Performance Capacities With Different Instrumentation Configurations, Saju John Mathew
Investigation Of Information Processing And Cognitive Performance Capacities With Different Instrumentation Configurations, Saju John Mathew
Bioengineering Theses - Archive
The focus of this thesis is the investigation of two new performance capacity tests related to a concept known as "situational awareness": 1) Visual Motor Multitask Performance Capacity (VMMPC) and 2) Visual Auditory Information Processing Dexterity (VAIPD). These represent major components of human information processing and are therefore important in situations ranging from driving and other activities of daily living to occupational and sport tasks. These tests have been recently designed and implemented on a laboratory-based instrument called the BEP I. In the present project, they are implemented on a different, more portable platform that is under development and known …
Spectroscopic Characterization Of Biliary Tract Tissues In-Vivo To Assist Laparoscopic Cholecystectomy, Sarita Kommera
Spectroscopic Characterization Of Biliary Tract Tissues In-Vivo To Assist Laparoscopic Cholecystectomy, Sarita Kommera
Bioengineering Theses - Archive
Laparoscopic Cholecystectomy is a surgical method for removal of gallbladder when it is diseased with gall stones. Almost 750,000 people are affected with this disease annually in USA. Gall bladder is removed by placing an incision on the cystic duct. This duct is totally embedded in fat (which is a few mm thick) in most of the cases and it becomes a huge problem decreasing the visual capability of the surgeon to distinctly locate the duct. Near Infrared Spectroscopy (NIRS) can solve the fuzziness as it penetrates in a few mm thick tissues. NIRS is one of the simplest techniques …
A Comprehensive Study Of The Effects Of Eeg Electrode Arrays On Mri Signal-To-Noise At 3t, Aman Ish Goyal
A Comprehensive Study Of The Effects Of Eeg Electrode Arrays On Mri Signal-To-Noise At 3t, Aman Ish Goyal
Bioengineering Theses - Archive
Simultaneous EEG-fMRI offers much potential for gaining complementary, noninvasive information about brain function. While much effort has been devoted to the compelling problem of removing ballistocardiogram and gradient artifacts from the EEG waveforms, less attention has been paid to the impact that increasing density of electrode arrays has on the MR images. Initial work reporting the effects of EEG caps and electrodes on the MR image has been site specific, using customized EEG equipment that those research groups built in-house. Therefore these results are hard to generalize to other laboratory environments. A monotonic decrease in SNR of the images has …
Miniature Optical Coherence Tomography Probe, Asif Rizwan
Miniature Optical Coherence Tomography Probe, Asif Rizwan
Bioengineering Theses - Archive
A piezo based optical scanner for high speed optical coherence tomography (OCT) has been developed. Design of the miniature probe has been optimized to take advantages of the high speed depth scanning that can be achieved with spectral domain OCT (SD-OCT) systems. Three prototype scanning probes were constructed and tested for OCT imaging. Movies and images of tissues are presented which were taken at frame rates ranging from 50~100fps. Data were acquired at 18000 A-lines per second at an effective integration time of 55us.
Optical Coherence Tomography Of Oral Mucosa, Nidhi Bharatbhai Mehta
Optical Coherence Tomography Of Oral Mucosa, Nidhi Bharatbhai Mehta
Bioengineering Theses - Archive
Oral cancer causes 120000* deaths annually around the world and 280000* new cases are diagnosed every year. Technology has developed and the death rate of oral cancer has improved over the last few decades; hence to improve the survival rate, development of a technique able to diagnose carcinomas in its early stages is very important. OCT is a non invasive imaging technique capable to provide high resolution microstructure images of tissue. A development of in vivo OCT; capable to image tissue with micrometer resolution and able to identify pre cancerous morphological changes non invasively could improve survival rate in cancer …
Fiber Based Non-Linear Excitation Fluorescence Microscopy, Priyanka Amrita Jillella
Fiber Based Non-Linear Excitation Fluorescence Microscopy, Priyanka Amrita Jillella
Bioengineering Theses - Archive
Non-linear excitation fluorescence microscopy is a high resolution, non-invasive biological imaging technique capable of imaging both in vitro and in vivo at the depths of several hundred microns. The goal of the thesis work is to contribute towards a fiber based non-linear excitation fluorescence microscopy system that we plan to build for our lab, which would later on be integrated with the OCT imaging setup and the DIC microscope. This thesis work involves filling in the key components in the microscopy system. These key components are; femtosecond pulse diagnosis, study of dispersion in optical media, dispersion free femtosecond pulse delivery …
Flow Rate Measurement Of In Situ Perfusion Through The Aqueous Humor Outflow Network, Noel Ortiz Lawrence
Flow Rate Measurement Of In Situ Perfusion Through The Aqueous Humor Outflow Network, Noel Ortiz Lawrence
Bioengineering Theses - Archive
A system was developed to measure the instantaneous perfusate flow rate through the aqueous humor outflow network of a human eye, while under constant pressure. The system monitors real-time weight changes of a perfusate reservoir associated with perfusate flow through the aqueous humor outflow network. The recorded weight changes of the reservoir are used as an indicator of flow rates. Methods to determine time and flow rate resolution and to control for evaporation were also developed. The system is capable of measuring flow on a uL/min scale; determined by the following model, which also includes a range of uncertainty (implies …
Detection Of Sleep Disordered Breathing Using Electroencephalography, Priya Xavier
Detection Of Sleep Disordered Breathing Using Electroencephalography, Priya Xavier
Bioengineering Theses - Archive
This study investigates the application of Electroencephalography (EEG) to detect Sleep disordered breathing (SDB) using power spectral analysis. A preliminary study was performed on 13 subjects (ages: 49.08 ± 8.82) previously diagnosed with OSA. Power spectral analysis was performed and centered on apnea/hypopnea event terminations. The normalized power changes between the frequency bands delta, theta, alpha and sigma were calculated using the Welch Averaging Periodogram method between 10 s of EEG data before the event termination and 10 s of EEG data after event termination. A significant decrease in normalized delta power and a significant increase in normalized theta, alpha …
Characterization And Feasibility Study Of A Near Infrared Ccd Imager For Monitoring Tumor Hemodynamics, Manan Goel
Characterization And Feasibility Study Of A Near Infrared Ccd Imager For Monitoring Tumor Hemodynamics, Manan Goel
Bioengineering Theses - Archive
Prostate cancer is one of the most common types of cancers diagnosed among North American men. Chemotherapy is generally used to target advanced metastatic prostate cancer. Near infrared spectroscopy (NIRS) has been previously investigated to monitor the hemodynamic changes in rat prostate tumors; however, the previous study with NIRS is limited by its spatial resolution. The goal of this study is to characterize an NIR, CCD imager and to explore the feasibility of using the CCD imager to non-invasively monitor hemodynamic changes in rat prostate tumors during gas intervention. Firstly, studies were conducted to characterize the CCD imager and understand …
Novel Techniques Of Fabricating Porous, Biodegradable Polymer Scaffolds For Sustained Drug Release, Mayur B. Uttarwar
Novel Techniques Of Fabricating Porous, Biodegradable Polymer Scaffolds For Sustained Drug Release, Mayur B. Uttarwar
Bioengineering Theses - Archive
Two types of porous scaffolds were made from biodegradable polymers and their drug release trends and rates were studied. In first method, the emulsion of PLLA in chloroform solution and PVA and acetaminophen in de-ionized water solution was made. The emulsion was blended with PLLA solution. The resultant emulsion was freeze vacuum dried. The drug release study was conducted in-vitro. In the second method, scaffolds had three layers. The top and bottom layers were made by blending PLLA solution with PVA solution. The middle layer was made by blending PLLA solution with a mixture of PVA and Acetaminophen in de-ionized …
Drug Loaded Polymeric Blends For Developing Vascular Stents, Anup C. Dasnurkar
Drug Loaded Polymeric Blends For Developing Vascular Stents, Anup C. Dasnurkar
Bioengineering Theses - Archive
In-stent restenosis and neo-intimal hyperplasia are long-term limitations of metallic stents. Local delivery of medications to transluminal angioplasty sites to prevent restenosis is receiving worldwide attention. Development of localized application of antiproliferative agents, and gene therapy via bio-degradable coatings on metallic substrates proved to be successful in reducing restenosis but was limited by the problems of limited drug load, etc. The presence of a foreign object for a long period of time may lead to the further narrowing of the treated lesion. The rationale for usage of bioresorbable drug eluting stents is the ability to store large quantities of drug …
Development Of An In-Vitro Assay For Neurotrophin-Induced Segregation Of Nociceptive And Proprioceptive Sensory Axons, Ebrahim Shabbir Bengali
Development Of An In-Vitro Assay For Neurotrophin-Induced Segregation Of Nociceptive And Proprioceptive Sensory Axons, Ebrahim Shabbir Bengali
Bioengineering Theses - Archive
Peripheral nerves have the capacity for regeneration and if properly repaired, axon extensions can regenerate even across gaps caused by peripheral nerve loss. Complete functional recovery after gap injury repair remains suboptimal due to the erroneous pathways taken by the regenerating axons leading to aberrant target innervation. A segregation of axonal types can facilitate efficient target direction and innervation leading to improved functional recovery. Novel two-dimensional and three-dimensional Y-shaped assays were developed to test whether the nociceptive and proprioceptive sensory axons from the dorsal root ganglia could be segregated through specific neurotrophin inducement; namely NGF and NT-3 respectively. A large …
Development Of Targeting Nanoparticles Mimicking The Adhesive Properties Of Platelets, Arthur Lin
Development Of Targeting Nanoparticles Mimicking The Adhesive Properties Of Platelets, Arthur Lin
Bioengineering Theses - Archive
The development of biodegradable nanoparticles as drug delivery vehicles presents an improved avenue for intracellular targeted drug delivery. Biodegradable nanoparticles have demonstrated an ability to provide controllable, sustained drug release in vitro. However, in vivo studies have shown that nanoparticles are not effective at adhering to vascular walls under shear stress. The purpose of this study was to investigate methods to improve cellular uptake and targeting of nanoparticles in activated or inflamed endothelial cells (ECs) under fluid shear stress and to determine whether the material properties of a biodegradable polymer, poly (lactic-co-glycolic) acid (PLGA), affected cellular uptake. The hypothesis for …
Novel Preparation Of Polymeric Scaffolds For Tissue Engineering Using Phase Separation With Protein Microbubble Incorporation, Ashwin Nair
Bioengineering Theses - Archive
Poly (lactic-co-glycolic acid) (PLGA) has been extensively used as a biodegradable and porous tissue scaffold due to their biocompatibility and degradability. Several techniques have been developed for the fabrication of polymeric scaffolds but they all have some limitation or the other which has in turn hampered the growth of cells seeded on them. Salt leached scaffolds have good porosity and large pores but poor mechanical strength and the problem of residual salt even after leaching. Similarly gas foaming scaffolds have shown large pores but poor interconnection with residual ammonium salts. Other methods like thermally induced phase separation and fiber bonding …
Use Of Near Infrared And Visible Spectroscopies To Determine Optical Properties Of Rat Nervous System, Harsha Radhakrishnan
Use Of Near Infrared And Visible Spectroscopies To Determine Optical Properties Of Rat Nervous System, Harsha Radhakrishnan
Bioengineering Theses - Archive
Changes to the anatomical or physiological structure of the neuronal circuitry are known to produce a change in the optical properties of the tissue under investigation. The goal of this thesis is to determine changes in the light scattering and hemoglobin oxygen saturation in three cases: (i) a normal spinal cord, (ii) demyelinated sciatic nerve, and (iii) spinal cord under neuronal activity induced by peripheral electrical stimulation. We hypothesize that (i) nerve demyelination or degeneration would result in a decrease in light scattering and hemoglobin oxygen saturation and (ii) peripheral electrical stimulation would show an increase in light scattering and …
Mr Susceptibility Weighted Imaging And Its Clinical Applications, Nandita R. Shetty
Mr Susceptibility Weighted Imaging And Its Clinical Applications, Nandita R. Shetty
Bioengineering Theses - Archive
Susceptibility Weighted Imaging (SWI) is a new T2* weighted Gradient Echo sequence that exploits the magnetic properties of tissues due to local inhomogeneities in the magnetic field. This technique was originally called 'High-Resolution Blood oxygen level dependent Venography' which, as the name suggests provides an increased visibility of the venous vasculature in the brain, including the minute vessels not seen on conventional imaging techniques. Since its potential is not restricted to venography, it was renamed 'Susceptibility Weighted Imaging ' due to its contrast mechanism being the susceptibility differences between two tissues. The essential feature in this technique is to tap …
A Novel Approach In The Detection Of Obstructive Sleep Apnea From Electrocardiogram Signals Using Neural Network Classification Of Textural Features Extracted From Time-Frequency Plots, Mohammad Alabed
Bioengineering Theses - Archive
Sleep-Disordered Breathing (SDB) is estimated to have a prevalence of 5% in middle-aged population. The population is widely thought to be under diagnosed, since the present method to detect and diagnose SDB, Nocturnal Polysomnography (NPSG), is still expensive and not accessible by most. SDB has been shown to affect the productivity and degree of life of the patient, and to have a high correlation with obesity and cognitive heart failure (CHF). Cheap and accessible means to screen the population for SDB are greatly pursued. This work presents an automatic algorithm to detect obstructive sleep apnea (OSA) events in 15-minute clips. …
Influence Of Polymer Surface Chemistry On The Recruitment Of Stem Cells In Mice, Shwetha Kamath
Influence Of Polymer Surface Chemistry On The Recruitment Of Stem Cells In Mice, Shwetha Kamath
Bioengineering Theses - Archive
The most troublesome biological response to the implantation of bloodcontacting biomaterials is inflammation, which thereby-sets in motion a cascade of adverse host responses. If devices for therapy and drug delivery could be developed that prevent such responses from occurring altogether, a new generation of "stealth" biomaterials would be born. Such was the motivation of this project, which sought to investigate using mouse subcutaneous implantation model, the implant mediated host tissue responses to surfaces differing in their functionalities. During the course of a previous study in our laboratory, we accidentally discovered the presence of stem cells and their accumulation at the …
Characterization Of A Noninvasive, In Vivo, Microscopic Hyperspectral Imaging System For Microvascular Visualization., Bhavesh Shah
Characterization Of A Noninvasive, In Vivo, Microscopic Hyperspectral Imaging System For Microvascular Visualization., Bhavesh Shah
Bioengineering Theses - Archive
Instrumentation with clinical implications for imaging the human oculus was developed, based upon the hyperspectral imaging modality. The novel, non invasive, microscopic multi-modal hyperspectral imaging system, which operates in the visible as well as near infrared region, is capable of generating images illustrating spatial distribution of oxyhemoglobin contributions. The device principally comprises of a liquid crystal tunable filter and a focal plane array detector that is integrated to the slit lamp microscope. A proof of principle clinical study involving ten healthy subjects was undertaken to image the microvascular structure within the dermal tissue within the near infrared region, however these …
Design And Construction Of A Fast Spectrometer For Fourier Domain Optical Coherence Tomography, Manish Kankaria
Design And Construction Of A Fast Spectrometer For Fourier Domain Optical Coherence Tomography, Manish Kankaria
Bioengineering Theses - Archive
A fast spectrometer capable of operating at 27.8 KHz is designed and calibrated to work in the wavelength range of 700-900 nm, to perform Fourier Domain Optical Coherence Tomography (FD-OCT). The OCT system is based on fiber-based Michelson's interferometer set up utilizing the spectrometer at the detector end. In FD-OCT system no reference scanning is necessary and hence images can be acquired at a much faster rate without any penalty to signal-to-noise ratio (SNR). A broadband Ti- sapphire source is used as input to this interferometer. Data at the rate of 60 MHz is acquired from the spectrometer using a …